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https://www.readbyqxmd.com/read/28698184/the-association-of-mammographic-density-and-molecular-breast-cancer-subtype
#1
Brandy L Edwards, Kristen A Atkins, George J Stukenborg, Wendy M Novicoff, Krista N Larson, Wendy F Cohn, Jennifer A Harvey, Anneke T Schroen
BACKGROUND: Mammographic density (MD) is associated with increased breast cancer (BC) risk, yet limited data exists on an association between MD and BC molecular subtypes. METHODS: Women 18 years and older with BC and available mammograms between 2003-2012 were enrolled in a larger study on MD. MD was classified by Breast Imaging Reporting and Data System (BI-RADS) classification and by volumetric breast percent density (Volpara SolutionsTM). Subtype was assigned by hormone receptor-status, tumor grade and mitotic score (MS)...
July 11, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28646773/survival-outcomes-of-patients-with-lobular-carcinoma-in-situ-who-underwent-bilateral-mastectomy-or-partial-mastectomy
#2
Ze-Ming Xie, Jian Sun, Zhe-Yu Hu, Yao-Pan Wu, Peng Liu, Jun Tang, Xiang-Sheng Xiao, Wei-Dong Wei, Xi Wang, Xiao-Ming Xie, Ming-Tian Yang
AIM: To compare the survival outcomes between patients treated with bilateral mastectomy and partial mastectomy alone as the initial surgical management for primary lobular carcinoma in situ (LCIS). PATIENTS AND METHODS: Patients with histologically confirmed LCIS underwent partial mastectomy alone or bilateral mastectomy were identified by the SEER*Stat database (version 8.3.2) released in 2016. The primary outcome measure was all-cause mortality and the secondary outcome measure was breast cancer-specific mortality...
June 21, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28637226/epidemiologic-risk-factors-for-in-situ-and-invasive-breast-cancer-among-postmenopausal-women-in-the-nih-aarp-diet-and-health-study
#3
Maeve Mullooly, Zeina G Khodr, Cher M Dallal, Sarah J Nyante, Mark E Sherman, Roni Falk, Linda M Liao, Jeffrey Love, Louise A Brinton, Gretchen L Gierach
Comparing risk factor associations between invasive breast cancers and possible precursors may further understanding of factors related to initiation versus progression. Accordingly, among 190,325 postmenopausal participants in the National Institutes of Health-AARP Diet and Health Study (1995-2011), we compared risk factor associations between incident ductal carcinoma in situ (DCIS: n = 1,453) and invasive ductal carcinomas (n = 7,525) and lobular carcinoma in situ (LCIS: n = 186) and invasive lobular carcinomas (n = 1,191)...
June 16, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28612228/pleomorphic-lobular-carcinoma-in-situ-of-the-breast-a-single-institution-experience-with-clinical-follow-up-and-centralized-pathology-review
#4
Marina De Brot, Starr Koslow Mautner, Shirin Muhsen, Victor P Andrade, Anita Mamtani, Melissa Murray, Dilip Giri, Rita A Sakr, Edi Brogi, Tari A King
PURPOSE: The natural history of pleomorphic lobular carcinoma in situ (PLCIS) remains largely unknown. METHODS: A pathology database search (1995-2012) was performed to identify patients diagnosed with an LCIS variant. Patients with synchronous breast cancer and/or no evidence of pleomorphism were excluded. Original slides were re-evaluated by three pathologists to identify a consensus cohort of PLCIS. Borderline lesions with focal atypia were classified as LCIS with pleomorphic features (LCIS-PF)...
June 13, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28611039/chemoprevention-uptake-among-women-with-atypical-hyperplasia-and-lobular-and-ductal-carcinoma-in-situ
#5
Meghna S Trivedi, Austin M Coe, Alejandro Vanegas, Rita Kukafka, Katherine D Crew
Women with atypical hyperplasia and lobular or ductal carcinoma in situ (LCIS/DCIS) are at increased risk of developing invasive breast cancer. Chemoprevention with selective estrogen receptor modulators or aromatase inhibitors can reduce breast cancer risk; however, uptake is estimated to be less than 15% in these populations. We sought to determine which factors are associated with chemoprevention uptake in a population of women with atypical hyperplasia, LCIS, and DCIS. Women diagnosed with atypical hyperplasia/LCIS/DCIS between 2007 and 2015 without a history of invasive breast cancer were identified (N = 1,719)...
June 13, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28574280/current-concepts-in-diagnosis-molecular-features-and-management-of-lobular-carcinoma-in-situ-of-the-breast-with-a-discussion-of-morphologic-variants
#6
Paula S Ginter, Timothy M D'Alfonso
CONTEXT: - Lobular carcinoma in situ (LCIS) refers to a neoplastic proliferation of cells that characteristically shows loss of E-cadherin expression and has long been regarded as a risk factor for invasive breast cancer. Long-term outcome studies and molecular data have also implicated LCIS as a nonobligate precursor to invasive carcinoma. In the past few decades, pleomorphic and florid LCIS have been recognized as morphologic variants of LCIS with more-aggressive histopathologic features, less-favorable biomarker profiles, and more-complex molecular features compared with classic LCIS...
June 2, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28541858/the-pathologic-finding-of-combined-lobular-carcinoma-in-situ-and-invasive-lobular-cancer-may-indicate-more-than-just-a-high-risk-marker-role-of-lobular-carcinoma-in-situ
#7
Christopher J Jean-Louis, Joshua Masdon, Betsy Smith, Oscar Battles, Paul Dale
For years, lobular carcinoma In Situ (LCIS) has been considered a high-risk marker for developing breast cancer. It is well known that ductal carcinoma In Situ is a precursor for the development of invasive ductal carcinoma, and ductal carcinoma In Situ is reported to be present in invasive ductal carcinoma in at least 40 per cent of cases. A similar relationship between LCIS and invasive lobular carcinoma (ILC) remains in question. This study evaluates the incidence of synchronous LCIS and ILC at our institution...
May 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28527397/mri-surveillance-for-women-with-dense-breasts-and-a-previous-breast-cancer-and-or-high-risk-lesion
#8
Michelle Nadler, Hyder Al-Attar, Ellen Warner, Anne L Martel, Sharmila Balasingham, Liying Zhang, Joseph H Lipton, Belinda Curpen
BACKGROUND: The role of surveillance breast MRI for women with mammographically dense breasts, a personal history of breast cancer (BC), atypical hyperplasia (AH), or lobular carcinoma in situ (LCIS) is unclear. We estimated the performance of annual surveillance MRI in women with a combination of these risk factors. METHODS: We performed a retrospective review of the clinical, radiological, and pathological parameters of women who received annual concurrent surveillance breast MRI and mammography between 04/2013 and 12/2015 and fulfilled all of the following criteria: 1) age <70; 2) prior diagnosis of AH, LCIS or BC; 3) heterogeneously or extremely dense breast(s); and 4) did not qualify for our provincial breast MRI high risk screening program...
August 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28507578/lobular-carcinoma-in-situ-of-the-breast-correlation-between-minimally-invasive-biopsy-and-final-pathology
#9
Bartłomiej Szynglarewicz, Piotr Kasprzak, Agnieszka Hałoń, Rafał Matkowski
INTRODUCTION: Lobular carcinoma in situ (LCIS) is regarded as a non-obligate precursor of invasive breast cancer (IBC). Hence, the optimal management of LCIS found on minimally invasive breast biopsy remains a subject of debate. The aim of this study was to evaluate the correlation of biopsy findings with postoperative histology and to identify risk factors for upstaging to IBC. MATERIAL AND METHODS: Twenty-seven patients with pure LCIS diagnosed on image-guided biopsy (vacuum-assisted or core-needle) underwent subsequent surgery...
April 1, 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28467490/risk-of-second-breast-cancers-after-lobular-carcinoma-in-situ-according-to-hormone-receptor-status
#10
Kai Mao, Yaping Yang, Wei Wu, Shi Liang, Heran Deng, Jieqiong Liu
BACKGROUND: Although subsequent breast cancer risk after primary lobular carcinoma in situ (LCIS) has been studied intensively, whether the risk of second breast cancer after first LCIS varies with hormone receptor (HR) status of primary tumor remains unclear. METHODS: We identified 10,304 women with primary pure unilateral LCIS between 1998 and 2007 from the Surveillance, Epidemiology and End Results (SEER) 18 Registries. Kaplan-Meier estimates of 5 or 10-year probabilities of second ipsilateral breast cancers (IBCs) and contralateral breast cancers (CBCs) were calculated...
2017: PloS One
https://www.readbyqxmd.com/read/28455673/population-based-analysis-of-breast-cancer-incidence-and-survival-outcomes-in-women-diagnosed-with-lobular-carcinoma-in-situ
#11
Stephanie M Wong, Tari King, Jean-Francois Boileau, William T Barry, Mehra Golshan
PURPOSE: A diagnosis of lobular carcinoma in situ (LCIS) is associated with an increased risk of developing breast cancer, although little data exist on long-term patient outcomes, including those who develop subsequent breast malignancies. METHODS: The Surveillance, Epidemiology, and End Results (SEER) database was used to identify women with a histological diagnosis of LCIS between 1983 and 2014. The incidence and clinicopathologic features of subsequent malignancies were then examined, and the Kaplan-Meier method and multivariable Cox PH regression used to obtain breast cancer-specific survival (BCSS) estimates and associated hazard ratios...
April 28, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28286021/role-of-breast-magnetic-resonance-imaging-in-predicting-residual-lobular-carcinoma-in-situ-after-initial-excision
#12
Ryu Kyung Lee, Hye Jung Kim, Jeeyeon Lee
BACKGROUND: Breast magnetic resonance (MR) imaging is a useful screening modality in detecting suspicious lesions in patients with a history of lobular carcinoma in situ (LCIS). This study aimed to evaluate the effectiveness of breast MR imaging in detecting remnant LCIS lesions after initial excision. METHODS: Between 2011 and 2015, 29 patients with LCIS who underwent initial excision were enrolled. Breast ultrasonography and breast MR imaging was conducted after initial excision...
March 9, 2017: Asian Journal of Surgery
https://www.readbyqxmd.com/read/28255630/breast-cancer-detection-by-preoperative-imaging-in-reduction-mammaplasty-patients-a-single-center-study-of-918-patients
#13
Päivi A Merkkola-von Schantz, Susanna M C Kauhanen, Tiina A Jahkola, Leena A Krogerus, Katja S Hukkinen
BACKGROUND: The role of preoperative imaging and the usability of different imaging modalities is highly variable and controversial in reduction mammaplasty patients. Our study describes the imaging process in a single center in regard to modality selection, age and timing, and of the association between imaging and histopathological findings in reduction mammaplasty specimens. METHODS: Nine hundred eighteen women, who underwent reduction mammaplasty during 1.1...
August 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28251346/cost-effectiveness-analysis-of-shunt-surgery-for-idiopathic-normal-pressure-hydrocephalus-based-on-the-sinphoni-and-sinphoni-2-trials
#14
Masahiro Kameda, Shigeki Yamada, Masamichi Atsuchi, Teruo Kimura, Hiroaki Kazui, Masakazu Miyajima, Etsuro Mori, Masatsune Ishikawa, Isao Date
BACKGROUND: We showed that ventriculoperitoneal (VP) shunt and lumboperitoneal (LP) shunt surgeries are beneficial for patients with idiopathic normal pressure hydrocephalus (iNPH) in the Study of Idiopathic Normal Pressure Hydrocephalus on Neurological Improvement (SINPHONI; a multicenter prospective cohort study) and in SINPHONI-2 (a multicenter randomized trial). Although therapeutic efficacy is important, cost-effectiveness analysis is equally valuable. METHODS: Using both a set of assumptions and using the data from SINPHONI and SINPHONI-2, we estimated the total cost of treatment for iNPH, which consists of medical expenses (e...
June 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28221673/breast-cancer-prevention-strategies-in-lobular-carcinoma-in-situ-a-decision-analysis
#15
Stephanie M Wong, Natasha K Stout, Rinaa S Punglia, Ipshita Prakash, Yasuaki Sagara, Mehra Golshan
BACKGROUND: Women diagnosed with lobular carcinoma in situ (LCIS) have a 3-fold to 10-fold increased risk of developing invasive breast cancer. The objective of this study was to evaluate the life expectancy (LE) and differences in survival offered by active surveillance, risk-reducing chemoprevention, and bilateral prophylactic mastectomy among women with LCIS. METHODS: A Markov simulation model was constructed to determine average LE and quality-adjusted LE (QALE) gains for hypothetical cohorts of women diagnosed with LCIS at various ages under alternative risk-reduction strategies...
February 21, 2017: Cancer
https://www.readbyqxmd.com/read/28112484/a-step-toward-regionalized-scale-consistent-agricultural-life-cycle-assessment-inventories
#16
Tiago G Morais, Ricardo Fm Teixeira, Tiago Domingos
Life cycle inventory (LCI) regionalization (i.e., the determination of input and output flows from production processes at a subcountry scale) is a priority in life cycle assessment (LCA) studies, particularly in the agri-food sector. Many regionalized LCAs fail to ensure that microlevel inventories are consistent with country-level aggregated data-or "scale consistent." They also fail to construct LCIs using international reference guidelines and trustworthy standardized data sources. This failure generates inaccuracies and biases in inventories and can compromise comparability among international LCA studies...
January 23, 2017: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/28095868/pik3ca-mutations-are-common-in-lobular-carcinoma-in-situ-but-are-not-a-biomarker-of-progression
#17
Vandna Shah, Salpie Nowinski, Dina Levi, Irek Shinomiya, Narda Kebaier Ep Chaabouni, Cheryl Gillett, Anita Grigoriadis, Trevor A Graham, Rebecca Roylance, Michael A Simpson, Sarah E Pinder, Elinor J Sawyer
BACKGROUND: Lobular carcinoma in situ (LCIS) is a non-invasive breast lesion that is typically found incidentally on biopsy and is often associated with invasive lobular carcinoma (ILC). LCIS is considered by some to be a risk factor for future breast cancer rather than a true precursor lesion. The aim of this study was to identify genetic changes that could be used as biomarkers of progression of LCIS to invasive disease using cases of pure LCIS and comparing their genetic profiles to LCIS which presented contemporaneously with associated ILC, on the hypothesis that the latter represents LCIS that has already progressed...
January 17, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28079289/apocrine-metaplasia-found-at-mr-biopsy-is-there-something-to-be-learned
#18
Yiming Gao, Vandana Dialani, Carolynn DeBenedectis, Nicole Johnson, Elena Brachtel, Priscilla Slanetz
The purpose of this study was to determine (a) the frequency of apocrine metaplasia (ApoM) found on MR core biopsy of suspicious findings, and (b) to determine if there are specific MR imaging features that might obviate the need for biopsy. This HIPAA-compliant retrospective study was performed under IRB exemption for quality assurance studies. Patient demographics, MR imaging features, and pathology were reviewed. Breast lesions which underwent MR-guided biopsy, yielding ApoM on pathology analysis were included...
January 12, 2017: Breast Journal
https://www.readbyqxmd.com/read/27986508/screening-breast-mri-outcomes-in-routine-clinical-practice-comparison-to-bi-rads-benchmarks
#19
Roberta M Strigel, Jennifer Rollenhagen, Elizabeth S Burnside, Mai Elezaby, Amy M Fowler, Frederick Kelcz, Lonie Salkowski, Wendy B DeMartini
RATIONALE AND OBJECTIVES: The BI-RADS Atlas 5th Edition includes screening breast magnetic resonance imaging (MRI) outcome benchmarks. However, the metrics are from expert practices and clinical trials of women with hereditary breast cancer predispositions, and it is unknown if they are appropriate for routine practice. We evaluated screening breast MRI audit outcomes in routine practice across a spectrum of elevated risk patients. MATERIALS AND METHODS: This Institutional Review Board-approved, Health Insurance Portability and Accountability Act-compliant retrospective study included all consecutive screening breast MRI examinations from July 1, 2010 to June 30, 2013...
April 2017: Academic Radiology
https://www.readbyqxmd.com/read/27930682/ecoalim-a-dataset-of-environmental-impacts-of-feed-ingredients-used-in-french-animal-production
#20
Aurélie Wilfart, Sandrine Espagnol, Sylvie Dauguet, Aurélie Tailleur, Armelle Gac, Florence Garcia-Launay
Feeds contribute highly to environmental impacts of livestock products. Therefore, formulating low-impact feeds requires data on environmental impacts of feed ingredients with consistent perimeters and methodology for life cycle assessment (LCA). We created the ECOALIM dataset of life cycle inventories (LCIs) and associated impacts of feed ingredients used in animal production in France. It provides several perimeters for LCIs (field gate, storage agency gate, plant gate and harbour gate) with homogeneously collected data from French R&D institutes covering the 2005-2012 period...
2016: PloS One
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