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A A Acott, A T Mancino
: Breast flat epithelial atypia (FEA) often coexists with more aggressive pathology and excision is currently recommended when diagnosed by core needle biopsy (CNB). Recent studies suggest isolated FEA has a low association with carcinoma and may warrant close surveillance. A radiology database containing 2189 breast CNB was reviewed for isolated FEA or FEA in combination with atypical pathology. 79 patients had FEA. There were 48/79 with isolated FEA and 31/79 concomitant FEA with ADH, ALH, or LCIS...
October 29, 2016: American Journal of Surgery
Esther Cheng, Timothy M D'Alfonso, Maria Arafah, Rebecca Marrero Rolon, Paula S Ginter, Syed A Hoda
Subareolar sclerosing duct hyperplasia (SSDH) remains to be fully characterized nearly 20 years after initial description. Thirty-five SSDH cases diagnosed over a 16-year period (January 2000 to December 2015) were reviewed. All patients were female (mean age = 59 years, range = 18-80) who had presented with a unilateral solitary lesion (left 22, right 13) with a mean size of 1.3 cm (range = 0.4-3.0 cm), and showed florid and papillary epithelial hyperplasia with dense sclerosis without involvement of nipple or areolar epidermis...
November 9, 2016: International Journal of Surgical Pathology
C Fives, C J O'Neill, R Murphy, M A Corrigan, M J O'Sullivan, L Feeley, M W Bennett, F O'Connell, T J Browne
BACKGROUND: The diagnosis and management of lobular neoplasia (LN) including lobular carcinoma in situ (LCIS) and atypical lobular hyperplasia (ALH) remains controversial. Current management options after a core needle biopsy (CNB) with lobular neoplasia (LN) incorporating both ALH and LCIS include excision biopsy or careful clinical and radiologic follow up. METHODS: A retrospective analysis of the surgical database at Cork University Hospital was performed to identify all core needle biopsies from January 1st 2010 to 31st December 2013 with a diagnosis of FA who subsequently underwent surgical excision biopsy...
December 2016: Breast: Official Journal of the European Society of Mastology
Melissa Murray
Percutaneous imaging-guided core needle biopsy (CNB) is a less invasive and less expensive alternative to surgical biopsy for the evaluation of breast lesions. After a CNB the radiologist determine if there is concordance between the pathology, imaging, and clinical findings. Patient management after CNB diagnosis of high-risk breast lesion varies. Surgical excision is warranted for lesions yielding a CNB diagnosis of ADH; however controversy exists regarding the need for surgical excision after CNB diagnosis of radial scar, papillary lesion, atypical lobular hyperplasia (ALH), or lobular carcinoma in situ (LCIS)...
December 2016: Clinical Obstetrics and Gynecology
Charlotta Wadsten, Hanna Heyman, Marit Holmqvist, Johan Ahlgren, Mats Lambe, Malin Sund, Fredrik Wärnberg
AIMS: Sweden has a long history of population-based cancer registration. The aim of our study was to assess the validity of DCIS registration in a regional Breast Cancer Quality Register (BCQR) and to analyze trends in incidence, treatment and outcome of DCIS, over a 20-year period. MATERIAL AND METHODS: All patients with a diagnosis of primary DCIS reported in the BCQR of the Uppsala-Örebro healthcare region in Sweden 1992-2012 were included. Three hundred women were randomly selected and their medical records were compared to register data...
November 2016: Acta Oncologica
Lauren Q Chang Sen, Wendie A Berg, Regina J Hooley, Gloria J Carter, Mohamed M Desouki, Jules H Sumkin
OBJECTIVE: The purpose of this article is to determine the upgrade rate to ductal carcinoma in situ (DCIS) or invasive carcinoma at excision at the same site after percutaneous breast biopsy findings of atypical lobular hyperplasia (ALH) or lobular carcinoma in situ (LCIS) using current imaging and strict pathologic criteria. MATERIALS AND METHODS: From January 2006 through September 2013, 32,960 breast core biopsies were performed; 1084 (3.3%) core biopsies found ALH or classic LCIS...
November 2016: AJR. American Journal of Roentgenology
Sarah A Cashman, David E Meyer, Ashley N Edelen, Wesley W Ingwersen, John P Abraham, William M Barrett, Michael A Gonzalez, Paul M Randall, Gerardo Ruiz-Mercado, Raymond L Smith
Demands for quick and accurate life cycle assessments create a need for methods to rapidly generate reliable life cycle inventories (LCI). Data mining is a suitable tool for this purpose, especially given the large amount of available governmental data. These data are typically applied to LCIs on a case-by-case basis. As linked open data becomes more prevalent, it may be possible to automate LCI using data mining by establishing a reproducible approach for identifying, extracting, and processing the data. This work proposes a method for standardizing and eventually automating the discovery and use of publicly available data at the United States Environmental Protection Agency for chemical-manufacturing LCI...
September 6, 2016: Environmental Science & Technology
Barbara Susnik, Deborah Day, Ellen Abeln, Tara Bowman, Janet Krueger, Karen K Swenson, Michaela L Tsai, Margit L Bretzke, Tamera J Lillemoe
BACKGROUND: Management recommendations for lobular neoplasia (LN) including lobular carcinoma-in-situ (LCIS) and atypical lobular hyperplasia (ALH) diagnosed in core biopsies (CB) are controversial. Our aim was to prospectively identify a subset of patients who do not require subsequent surgical excision (SE). PATIENTS AND METHODS: All patients diagnosed with LN on CB were enrolled and referred for SE. Cases with coexistent ductal carcinoma-in-situ or invasive carcinoma were excluded...
December 2016: Clinical Breast Cancer
A Jung Chu, Nariya Cho, In-Ae Park, Seong Whi Cho
PURPOSE: To evaluate imaging features of pure lobular carcinoma in situ (LCIS) on magnetic resonance imaging (MRI) in patients who underwent immediate re-excision after lumpectomy. METHODS: Twenty-six patients (46.1±6.7 years) with 28 pure LCIS lesions, who underwent preoperative MRI and received curative surgery at our institution between 2005 and 2013, were included in this study. Clinicopathologic features associated with immediate re-excision were reviewed and analyzed using Fisher exact test or the Wilcoxon signed rank test...
June 2016: Journal of Breast Cancer
Colin B Begg, Irina Ostrovnaya, Jose V Scarpa Carniello, Rita A Sakr, Dilip Giri, Russell Towers, Michail Schizas, Marina De Brot, Victor P Andrade, Audrey Mauguen, Venkatraman E Seshan, Tari A King
BACKGROUND: Recent evidence suggests that lobular carcinoma in situ (LCIS) can be a clonal precursor of invasive breast cancers of both the ductal and lobular phenotypes. We sought to confirm these findings with an extensive study of fresh frozen breast specimens from women undergoing mastectomy. METHODS: Patients with a history of LCIS presenting for therapeutic mastectomy were identified prospectively. Frozen tissue blocks were collected, screened for lesions of interest, and subjected to microdissection and DNA extraction...
2016: Breast Cancer Research: BCR
Susanne I Fuchs, Nicolaus Schwerk, Klaus Pittschieler, Frank Ahrens, Winfried Baden, Robert Bals, Sebastian Fähndrich, Wolfgang Gleiber, Matthias Griese, Georg Hülskamp, Thomas Köhnlein, Ludmilla Reckling, Ernst Rietschel, Doris Staab, Monika Gappa
Patients with alpha-1-antitrypsin deficiency (AATD) and a PI-ZZ genotype are at high risk to develop severe emphysema during adulthood. However, little is known about early stages of emphysema and disease manifestation in other PI-types. Spirometry is commonly used for monitoring although early manifestation of emphysema is suspected within the peripheral airways that are not accessible by forced expiratory manoeuvres. We hypothesized that the Lung Clearance Index (LCI) derived from multiple breath nitrogen-washout (N2-washout) is useful to bridge this diagnostic gap...
July 2016: Respiratory Medicine
Matthias Christgen, Doris Steinemann, Elna Kühnle, Florian Länger, Oleg Gluz, Nadia Harbeck, Hans Kreipe
Infiltrating lobular breast cancer (ILBC) is the most common special breast cancer subtype. This review provides a comprehensive description of ILBC characteristics, including epidemiology, clinical features, molecular genetics and histomorphology. Twenty detailed supplemental data tables guide through primary data of more than 200 original studies. Meta-analyses indicate that ILBC is at least twice as common in the Western world as it is in other geographic regions. ILBC is over-represented in so-called interval carcinomas and in primary metastatic breast cancer...
July 2016: Pathology, Research and Practice
Samilia Obeng-Gyasi, Cecilia Ong, E Shelley Hwang
The management of in situ lesions ductal carcinoma in situ (DCIS) and lobular carcinoma in situ (LCIS) continues to evolve. These diagnoses now comprise a large burden of mammographically diagnosed cancers, and with a global trend towards more population-based screening, the incidence of these lesions will continue to rise. Because outcomes following treatment for DCIS and LCIS are excellent, there is emerging controversy about what extent of treatment is optimal for both diseases. Here we review the current approaches to the diagnosis and treatment of both DCIS and LCIS...
June 2016: Chinese Clinical Oncology
Ying Wang, Sonali Jindal, Maritza Martel, Yaping Wu, Pepper Schedin, Megan Troxell
Myoepithelial cells have important physical and paracrine roles in breast tissue development, maintenance, and tumor suppression. Recent molecular and immunohistochemical studies have demonstrated phenotypic alterations in ductal carcinoma in situ-associated myoepithelial cells. Although the relationship of lobular carcinoma in situ (LCIS) and myoepithelial cells was described in 1980, further characterization of LCIS-associated myoepithelial cells is lacking. We stained 27 breast specimens harboring abundant LCIS with antibodies to smooth muscle myosin heavy chain, smooth muscle actin, and calponin...
September 2016: Human Pathology
Maeva Fischer-Hunsinger, Jean-Marc Guinebretière, Serge Lasry, Adriana Langer, Hélène Berment, Ibtissem Nekka, Philippe Nodiot, Pascal Cherel
OBJECTIVE: Lobular intraepithelial neoplasia (LIN) diagnosed on image-guided biopsy may be associated with an undiagnosed cancer. This is called under-diagnosis. The consequence is that management of these lesions is often surgical. But many surgeries finally are unnecessary. The aim of our study was to define criteria to avoid unnecessary surgery. MATERIALS AND METHODS: This is a single-center, retrospective after a database collected prospectively study. Fourteen thousand biopsies were analyzed, including 456 diagnosed NLI...
May 2016: Bulletin du Cancer
S Tanaka, N Kanomata, K Teramura, K Wakita, T Kunihisa, Y Yano, T Moriya, Y Hayashi
OBJECTIVE: The Breast Marker Cocktail from Biocare Medical comprises five antibodies recognising p63, and cytokeratins (CKs) 7, 18, 5 and 14. Immunohistochemistry using this cocktail is useful for diagnosing proliferative intraductal breast lesions. However, cytology using the cocktail has not been reported. METHODS: We report 139 cases of mammary samples collected by fine needle aspiration (FNA) for which histological diagnoses were available. After cell transfer, immunocytochemistry was performed using the cocktail, and clusters of cells were classified...
April 6, 2016: Cytopathology: Official Journal of the British Society for Clinical Cytology
Andrew A Renshaw, Edwin W Gould
Atypical ductal hyperplasia (ADH) and lobular carcinoma in situ (LCIS) may be associated with a relatively high incidence of invasive carcinoma and ductal carcinoma in situ (DCIS) on immediate excision when found on core needle biopsy of the breast. However, the long term significance of ADH and LCIS in a breast core needle biopsy is not as well characterised. We reviewed the results of all breast core needle biopsies with a diagnosis of ADH or LCIS and immediate excision from the years 2000-2004, and correlated the results with long term clinical follow-up...
January 2016: Pathology
Vincent Lavoué, Xavier Fritel, Martine Antoine, Françoise Beltjens, Sofiane Bendifallah, Martine Boisserie-Lacroix, Loic Boulanger, Geoffroy Canlorbe, Sophie Catteau-Jonard, Nathalie Chabbert-Buffet, Foucauld Chamming's, Elisabeth Chéreau, Jocelyne Chopier, Charles Coutant, Julie Demetz, Nicolas Guilhen, Raffaele Fauvet, Olivier Kerdraon, Enora Laas, Guillaume Legendre, Carole Mathelin, Cédric Nadeau, Isabelle Thomassin Naggara, Charlotte Ngô, Lobna Ouldamer, Arash Rafii, Marie-Noelle Roedlich, Jérémy Seror, Jean-Yves Séror, Cyril Touboul, Catherine Uzan, Emile Daraï
Screening with breast ultrasound in combination with mammography is needed to investigate a clinical breast mass (Grade B), colored single-pore breast nipple discharge (Grade C), or mastitis (Grade C). The BI-RADS system is recommended for describing and classifying abnormal breast imaging findings. For a breast abscess, a percutaneous biopsy is recommended in the case of a mass or persistent symptoms (Grade C). For mastalgia, when breast imaging is normal, no MRI or breast biopsy is recommended (Grade C). Percutaneous biopsy is recommended for a BI-RADS category 4-5 mass (Grade B)...
May 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Luciana Graziano, Almir Galvão Vieira Bitencourt, Camila Souza Guatelli, Juliana Alves Souza, Cynthia Aparecida Bueno de Toledo Osório, Miriam Rosalina Brites Poli, Elvira Ferreira Marques
Lobular carcinoma in situ (LCIS) is associated with an increased risk of breast cancer and accounts for 1 to 2% of all breast cancers. LCIS diagnosis currently remains one of the major identifiable risk factors for subsequent breast cancer development. Imaging methods are becoming increasingly sensitive, and the consequent detection of small lesions and subtle abnormalities increases the chance of detection of in situ and invasive carcinomas, leading to a reduction in mortality. This report describes a case of a palpable complaint with abnormal imaging findings, including a solid LCIS mass...
February 2016: Revista Brasileira de Ginecologia e Obstetrícia
Carlos Parra-Herran, Tyna Hope, Taha Rashed, Elzbieta Slodkowska, Fang-I Lu, Sharon Nofech-Mozes
OBJECTIVE: To identify quantitative histological features that can differentiate between low grade ductal carcinoma in situ (LG-DCIS) and classic type lobular carcinoma in situ (C-LCIS). STUDY DESIGN: Regions of solid intraductal proliferation from scanned hematoxylin and eosin images of LG-DCIS (20 cases) and C-LCIS (25 cases) were analyzed using Mercator Version 1.0 (ExploraNova, La Rochelle, France). The system detects structures based on optical density. Multiple variables were measured, including estimators of size (mean nuclear area), shape (form factor), and staining (grayscale value)...
December 2015: Analytical and Quantitative Cytopathology and Histopathology
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