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https://www.readbyqxmd.com/read/29762338/incidence-and-risk-factors-for-instrumentation-related-complications-after-scoliosis-surgery-in-pediatric-patients-with-nf-1
#1
Ziming Yao, Hao Li, Xuejun Zhang, Chengxin Li, Xinyu Qi
STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To assess the incidence and risk factors of instrumentation-related complication (IRC) in pediatric patients surgically treated for neurofibromatosis type 1 (NF-1) dystrophic scoliosis. SUMMARY OF BACKGROUND DATA: Surgical management including growing rods technique and early definitive fusion has been recommended to avoid progression of NF-1 scoliosis. However, no study has yet investigated the incidence and risk factors of IRC in these surgical interventions...
May 14, 2018: Spine
https://www.readbyqxmd.com/read/29735144/construct-levels-to-anchored-levels-ratio-and-rod-diameter-are-associated-with-implant-related-complications-in-traditional-growing-rods
#2
Pooria Hosseini, Behrooz A Akbarnia, Stacie Nguyen, Jeff Pawelek, John Emans, Peter F Sturm, Paul D Sponseller
INTRODUCTION: In addition to patient characteristics, consideration of length of construct to number of anchored levels ratio and rod diameter should be a part of preoperative planning to minimize implant-related complications (IRCs). IRCs including rod breakage, anchor dislodgement, and pullout are among the most common adverse events in traditional growing rods (TGRs). The current study hypothesized that anchor type and configuration are associated with IRC. METHODS: Patients with (1) age ≤10 years at surgery; (2) spine-based dual TGR; (3) minimum 2-year follow-up; and (4) available imaging...
May 2018: Spine Deformity
https://www.readbyqxmd.com/read/29676661/atomistic-mechanisms-of-the-double-proton-transfer-in-the-h-bonded-nucleobase-pairs-qm-qtaim-computational-lessons
#3
Ol'ha O Brovarets', Dmytro M Hovorun
In this Review we have summarized and generalized the results of the investigation of the microstructural mechanisms of the tautomerisation by the counter movement of the protons along the neighboring intermolecular H-bonds in 22 biologically important pairs of nucleotide bases in the framework of the original method, which allows to trace the evolution of the physico-chemical parameters, that characterize these processes along the intrinsic reaction coordinate (IRC). It was demonstrated the performance of the introduction of the conception of the key points (KPs) (from nine to five, depending on the symmetry and nature of system), which exhaustively characterize the flow of the tautomerisation processes...
April 20, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29675301/deep-learning-approach-for-the-detection-and-quantification-of-intraretinal-cystoid-fluid-in-multivendor-optical-coherence-tomography
#4
Freerk G Venhuizen, Bram van Ginneken, Bart Liefers, Freekje van Asten, Vivian Schreur, Sascha Fauser, Carel Hoyng, Thomas Theelen, Clara I Sánchez
We developed a deep learning algorithm for the automatic segmentation and quantification of intraretinal cystoid fluid (IRC) in spectral domain optical coherence tomography (SD-OCT) volumes independent of the device used for acquisition. A cascade of neural networks was introduced to include prior information on the retinal anatomy, boosting performance significantly. The proposed algorithm approached human performance reaching an overall Dice coefficient of 0.754 ± 0.136 and an intraclass correlation coefficient of 0...
April 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29628518/the-abundance-of-sic-2-in-carbon-star-envelopes-evidence-that-sic-2-is-a-gas-phase-precursor-of-sic-dust
#5
Sarah Massalkhi, M Agúndez, J Cernicharo, L Velilla Prieto, J R Goicoechea, G Quintana-Lacaci, J P Fonfría, J Alcolea, V Bujarrabal
Context: Silicon carbide dust is ubiquitous in circumstellar envelopes around C-rich AGB stars. However, the main gas-phase precursors leading to the formation of SiC dust have not yet been identified. The most obvious candidates among the molecules containing an Si-C bond detected in C-rich AGB stars are SiC2 , SiC, and Si2 C. To date, the ring molecule SiC2 has been observed in a handful of evolved stars, while SiC and Si2 C have only been detected in the C-star envelope IRC +10216...
March 2018: Astronomy and Astrophysics
https://www.readbyqxmd.com/read/29584486/novel-method-of-estimating-aroc-using-an-injury-risk-curve-for-biomechanical-injury-metric-selection
#6
Alexander Baker, Fang-Chi Hsu, Scott Gayzik
OBJECTIVE: Area under the receiver operating characteristic (AROC) is commonly used to evaluate an injury metric's ability to discriminate between injury and noninjury cases. However, AROC has limitations and may not handle censored data sets adequately. Survival methodology creates robust estimates of injury risk curves (IRCs) which accommodate censored data. We developed an observation-adjusted ROC (oaROC), an AROC-like statistic calculated from the IRC. METHODS: oaROC uses an observational distribution and an IRC to measure true positive rate (TPR) and false positive rate (FPR)...
February 28, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29560493/finite-element-based-pelvic-injury-metric-creation-and-validation-in-lateral-impact-for-a-human-body-model
#7
Caitlin Weaver, Alexander Baker, Matthew Davis, Anna Miller, Joel D Stitzel
Pelvic fractures are serious injuries resulting in high mortality and morbidity. The objective of this study is to develop and validate local pelvic anatomical, cross-section-based injury risk metrics for a finite element (FE) model of the human body. Cross-sectional instrumentation was implemented in the pelvic region of the Global Human Body Models Consortium (GHBMC M50-O) 50th percentile detailed male FE model (v4.3). In total, 25 lateral impact FE simulations were performed using input data from cadaveric lateral impact tests performed by Bouquet et al...
February 20, 2018: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29560439/c-c-bond-formation-in-the-intramolecular-diels-alder-reaction-of-triene-amides
#8
Abdelilah Benallou, Habib El Alaoui El Abdallaoui, Hocine Garmes
The mechanism nature of the intramolecular Diels-Alder reaction has been performed; and thus, the changes of C-C bond forming/breaking along IRC are characterized in this study. Conceptual DFT analyses of the most favorable adduct fused/exo shows that the flux electronic will take place from diene to dienophile moiety. Moreover, ELF topological analysis based on the electron density predicts that C-C bond is formed by the coupling of two pseudoradical centers generated at the most significant atoms of the molecules...
February 2018: Heliyon
https://www.readbyqxmd.com/read/29550566/cabozantinib-versus-sunitinib-as-initial-therapy-for-metastatic-renal-cell-carcinoma-of-intermediate-or-poor-risk-alliance-a031203-cabosun-randomised-trial-progression-free-survival-by-independent-review-and-overall-survival-update
#9
Toni K Choueiri, Colin Hessel, Susan Halabi, Ben Sanford, M Dror Michaelson, Olwen Hahn, Meghara Walsh, Thomas Olencki, Joel Picus, Eric J Small, Shaker Dakhil, Darren R Feldman, Milan Mangeshkar, Christian Scheffold, Daniel George, Michael J Morris
BACKGROUND: The randomised phase 2 CABOSUN trial comparing cabozantinib with sunitinib as initial therapy for advanced renal cell carcinoma (RCC) of intermediate or poor risk met the primary end-point of improving progression-free survival (PFS) as assessed by investigator. We report PFS by independent radiology review committee (IRC) assessment, ORR per IRC and updated overall survival (OS). PATIENTS AND METHODS: Previously untreated patients with advanced RCC of intermediate or poor risk by IMDC criteria were randomised 1:1 to cabozantinib 60 mg daily or sunitinib 50 mg daily (4 weeks on/2 weeks off)...
May 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29526277/idiopathic-restrictive-cardiomyopathy-in-children-and-young-adults
#10
Heather N Anderson, Frank Cetta, David J Driscoll, Timothy M Olson, Michael J Ackerman, Jonathan N Johnson
Idiopathic restrictive cardiomyopathy (IRC) is a rare condition characterized by reduced ventricular compliance. Children with IRC have poor outcomes with most patients proceeding to cardiac transplantation. We sought to analyze our institutional experience and assess contemporary outcomes for children with IRC. We reviewed the medical record for patients (<21 years old) evaluated for a primary diagnosis of IRC between 1975 and 2013 at our institution. Demographic, clinical, echocardiographic, and catheterization data were abstracted...
May 15, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29503017/a-method-to-measure-predictive-ability-of-an-injury-risk-curve-using-an-observation-adjusted-area-under-the-receiver-operating-characteristic-curve
#11
A M Baker, F C Hsu, F S Gayzik
Area under the receiver operating characteristic curve (AROC) is commonly used to choose a biomechanical metric from which to construct an injury risk curve (IRC). However, AROC may not handle censored datasets adequately. Survival analysis creates robust estimates of IRCs which accommodate censored data. We present an observation-adjusted ROC (oaROC) which uses the survival-based IRC to estimate the AROC. We verified and evaluated this method using simulated datasets of different censoring statuses and sample sizes...
April 27, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29464735/molup-a-vmd-plugin-to-handle-qm-and-oniom-calculations-using-the-gaussian-software
#12
Henrique S Fernandes, Maria J Ramos, Nuno M F S A Cerqueira
The notable advances obtained by computational (bio)chemistry provided its widespread use in many areas of science, in particular, in the study of reaction mechanisms. These studies involve a huge number of complex calculations, which are often carried out using the Gaussian suite of programs. The preparation of input files and the analysis of the output files are not easy tasks and often involve laborious and complex steps. Taking this into account, we developed molUP: a VMD plugin that offers a complete set of tools that enhance the preparation of QM and ONIOM (QM/MM, QM/QM, and QM/QM/MM) calculations...
February 21, 2018: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/29456257/irc-10-216-in-3-d-morphology-of-a-tp-agb-star-envelope
#13
M Guélin, N A Patel, M Bremer, J Cernicharo, A Castro-Carrizo, J Pety, J P Fonfría, M Agúndez, M Santander-García, G Quintana-Lacaci, L Velilla Prieto, R Blundell, P Thaddeus
During their late pulsating phase, AGB stars expel most of their mass in the form of massive dusty envelopes, an event that largely controls the composition of interstellar matter. The envelopes, however, are distant and opaque to visible and NIR radiation: their structure remains poorly known and the mass-loss process poorly understood. Millimeter-wave interferometry, which combines the advantages of longer wavelength, high angular resolution and very high spectral resolution is the optimal investigative tool for this purpose...
February 2018: Astronomy and Astrophysics
https://www.readbyqxmd.com/read/29453475/basal-cell-carcinoma-in-cases-with-or-without-xeroderma-pigmentosum
#14
Dilasma Ghartimagar, Arnab Ghosh, Sushil Ram Shrestha, Sachet Shrestha, Sushma Thapa, Raghavan Narasimhan, O P Talwar
INTRODUCTION: Basal cell carcinoma is the most common form of cancer in humans and comprises the vast majority of skin cancers. It predominantly affects fair-skinned individuals, and its incidence is rapidly increasing. The objective of the study is to identify the epidemiology, its topography and different histological subtypes of basal cell carcinoma in patients with or without Xeroderma Pigmentosum. METHODS: A cross-sectional descriptive study was conducted at Manipal Teaching Hospital, Pokhara from Jan 2009 to Dec 2016...
October 2017: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/29431772/the-reactivity-of-cyclopropyl-cyanide-in-titan-s-atmosphere-a-possible-pre-biotic-mechanism
#15
E López, D Ascenzi, P Tosi, J M Bofill, J de Andrés, M Albertí, J M Lucas, A Aguilar
Cyclopropyl cyanide and other simple nitriles detected in Titan's atmosphere could be precursors leading to the formation of organic macromolecules in the atmosphere of Saturn's largest satellite. Proposing a thermodynamically possible mechanism that explains their formation and supports experimental results represents a difficult challenge. Experiments done in the Atomic and Molecular Physics Laboratory at the University of Trento (AMPL) have studied the ion-molecule reaction between cyclopropyl cyanide and its protonated form, with reaction products being characterized by mass spectrometry...
February 28, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29399307/the-clinical-efficacy-of-infrared-photocoagulation-versus-closed-hemorrhoidectomy-in-treatment-of-hemorrhoid
#16
Mohammad Reza Nikshoar, Zahra Maleki, Behzad Nemati Honar
Introduction: Infrared photocoagulation (IRC) was introduced as a mainstay procedure for treatment of hemorrhoids. The present study aimed to compare the clinical efficacy of IRC compared to closed hemorrhoidectomy. Methods: Forty patients suffering grade-3 hemorrhoid that referred to the surgery clinic at Imam Hossein hospital in Tehran in 2013 were randomly assigned to groups treated with the IRC modality or Ferguson's closed hemorrhoidectomy method. The patients in the 2 groups were followed-up for the first 24 hours after surgery and 8 weeks later...
2018: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/29390924/a-4-gene-expression-prognostic-signature-might-guide-post-remission-therapy-in-patients-with-intermediate-risk-cytogenetic-acute-myeloid-leukemia
#17
Montserrat Torrebadell, Marina Díaz-Beyá, Susana G Kalko, Marta Pratcorona, Josep Nomdedeu, Alfons Navarro, Bernat Gel, Salut Brunet, Jorge Sierra, Mireia Camós, Jordi Esteve
In intermediate-risk cytogenetic acute myeloid leukemia (IRC-AML) patients, novel biomarkers to guide post-remission therapy are needed. We analyzed with high-density arrays 40 IRC-AML patients who received a non-allogeneic hematopoietic stem-cell transplantation-based post-remission therapy, and identified a signature that correlated with early relapse. Subsequently, we analyzed selected 187 genes in 49 additional IRC-AML patients by RT-PCR. BAALC, MN1, SPARC and HOPX overexpression correlated to refractoriness...
February 2, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29389610/inulin-rich-carbohydrates-extraction-from-jerusalem-artichoke-helianthus-tuberosus-l-tubers-and-application-of-different-drying-methods
#18
Irene A Rubel, Carolina Iraporda, Rocio Novosad, Fernanda A Cabrera, Diego B Genovese, Guillermo D Manrique
In this study the operational extraction variables to obtain higher yields of inulin from Jerusalem artichoke tubers (JAT), as well as the optimal conditions to obtain a stable and dispersible powdered product by either spray or freeze drying, were studied. With this purpose, the powder yield, moisture content, water activity and flowability or products obtained by different experimental conditions were analyzed. Inulin rich carbohydrates (IRC) extraction was performed from lyophilized and ground tubers employing distilled hot water as solvent...
January 2018: Food Research International
https://www.readbyqxmd.com/read/29387476/immune-checkpoint-inhibition-related-colitis-symptoms-endoscopic-features-histology-and-response-to-management
#19
REVIEW
Marnix H Geukes Foppen, Elisa A Rozeman, Sandra van Wilpe, Cindy Postma, Petur Snaebjornsson, Johannes V van Thienen, Monique E van Leerdam, Michel van den Heuvel, Christian U Blank, Jolanda van Dieren, John B A G Haanen
Background: Immune checkpoint inhibitors are successfully introduced as anticancer treatment. However, they may induce severe immune-related adverse events (irAEs). One of the most frequent irAEs is diarrhoea. The main objective of this study was to analyse symptoms (ie, grade of diarrhoea), endoscopic and histological features and response to management in immune checkpoint inhibition-related colitis (IRC). Patients and methods: We retrospectively analysed patients who developed diarrhoea on checkpoint inhibition and therefore underwent an endoscopy and/or were treated with corticosteroids...
2018: ESMO Open
https://www.readbyqxmd.com/read/29385614/induction-of-autophagy-and-interleukin-6-secretion-in-bystander-cells-metabolic-cooperation-for-radiation-induced-rescue-effect
#20
Eva Yi Kong, Shuk Han Cheng, Kwan Ngok Yu
We hypothesized that radiation-induced rescue effect (RIRE) shared similar mechanisms with 'metabolic cooperation', in which nutrient-deprived cancer cells prompted normal cells to provide nutrients. Our data demonstrated that X-ray irradiation induced autophagy in HeLa cells, which could last at least 18 h, and proved that the irradiated cells (IRCs) resorted to breaking down their own intracellular components to supply the molecules required for cell-repair enhancement (e.g. to activate the NF-κB pathway) in the absence of support from bystander unirradiated cells (UICs)...
March 1, 2018: Journal of Radiation Research
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