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https://www.readbyqxmd.com/read/27892571/the-reaction-fragility-spectrum
#1
Ludwik Komorowski, Piotr Ordon, Mateusz Jędrzejewski
We report an original method that provides a new insight into the reaction mechanism by direct observation of bond breaking and formation. Variations of the diagonal elements of the Hessian along the IRC are shown to reflect the anharmonic properties of the system that are induced by electron density modifications upon the reaction. This information is presented in the form of the reaction spectrum, demonstrating how particular atoms engage in the reorganization of bonds. The test reactions are: HCOF synthesis and HONS isomerization...
November 28, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27890838/preoperative-evaluation-of-the-renal-function-before-the-treatment-of-abdominal-aortic-aneurysms
#2
Raphael Coscas, Sandra Wagner, Eve Vilaine, Albane Sartorius, Isabelle Javerliat, Olivier Goeau-Brissonniere, Marc Coggia, Ziad Massy
OBJECTIVES: Chronic impaired renal function (IRC) constitutes a major risk factor of morbi-mortality during the treatment of an abdominal aortic aneurism (AAA). The inflammatory state due to the AAA could result in a reduction in the muscular mass and an over-estimation of the glomerular filtration rate (GFR) with the usual formulas. The objective of this study was to determine if the formulae used to evaluate the estimated GFR were adapted in patients with AAA. MATERIALS AND METHODS: Between August 2013 and November 2014, we conducted an exploratory study to evaluate the renal function before surgery for AAA in 28 patients...
November 24, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27875879/guided-ion-beam-and-theoretical-studies-of-the-reactions-of-re-os-and-ir-with-co
#3
JungSoo Kim, Richard M Cox, P B Armentrout
The kinetic-energy dependences of the reactions M(+) + CO where M(+) = Re(+), Os(+), and Ir(+) are studied using guided ion-beam tandem mass spectrometry. Formation of both MO(+) and MC(+) was observed in endothermic processes for all three metals. Modeling of the data provides thresholds that yield 0 K bond dissociation energies (BDEs, in eV) of 4.67 ± 0.09 (Re(+)-O), 4.82 ± 0.14 (Os(+)-O), 4.25 ± 0.11 (Ir(+)-O), 5.13 ± 0.12 (Re(+)-C), 6.14 ± 0.14 (Os(+)-C), and 6.58 ± 0.12 (Ir(+)-C). These BDEs agree well with literature values within experimental uncertainties demonstrating that ground state products are formed for all cases even though some of the reactions are formally spin forbidden...
November 21, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27863201/pooled-analysis-of-cns-response-to-alectinib-in-two-studies-of-pretreated-patients-with-alk-positive-non-small-cell-lung-cancer
#4
Shirish M Gadgeel, Alice T Shaw, Ramaswamy Govindan, Leena Gandhi, Mark A Socinski, D Ross Camidge, Luigi De Petris, Dong-Wan Kim, Alberto Chiappori, Denis L Moro-Sibilot, Michael Duruisseaux, Lucio Crino, Tommaso De Pas, Eric Dansin, Antje Tessmer, James Chih-Hsin Yang, Ji-Youn Han, Walter Bordogna, Sophie Golding, Ali Zeaiter, Sai-Hong Ignatius Ou
Purpose Alectinib has shown activity in the CNS in phase I and II studies. To further evaluate this activity, we pooled efficacy and safety data from two single-arm phase II studies (NP28761 and NP28673; ClinicalTrials.gov identifiers: NCT01871805 and NCT01801111, respectively) in patients with ALK-positive non-small-cell lung cancer (NSCLC). Patients and Methods Both studies included patients with ALK-positive NSCLC who had previously received crizotinib; all patients received alectinib 600 mg twice per day...
December 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27831729/a-randomized-problem-solving-trial-for-adolescent-brain-injury-changes-in-social-competence
#5
Sarah J Tlustos, Michael W Kirkwood, H Gerry Taylor, Terry Stancin, Tanya M Brown, Shari L Wade
PURPOSE/OBJECTIVE: Traumatic brain injury (TBI) in adolescence has well documented effects on social competence. Few studies have examined the effects of behavioral interventions on social competence or identified factors associated with changes in social competence after injury. Research Method/Design: Adolescents with moderate to severe TBI ages 12-17 years were randomized within 6 months of injury to either a problem solving and communication (CAPS) group that received online counseling (n = 65) or an Internet resources comparison (IRC) group (n = 67) for a comparative effectiveness trial...
November 2016: Rehabilitation Psychology
https://www.readbyqxmd.com/read/27805902/association-of-foxd1-variants-with-adverse-pregnancy-outcomes-in-mice-and-humans
#6
Paul Laissue, Besma Lakhal, Magalie Vatin, Frank Batista, Gaëtan Burgio, Eric Mercier, Esther Dos Santos, Christophe Buffat, Diana Carolina Sierra-Diaz, Gilles Renault, Xavier Montagutelli, Jane Salmon, Philippe Monget, Reiner A Veitia, Céline Méhats, Marc Fellous, Jean-Christophe Gris, Julie Cocquet, Daniel Vaiman
Recurrent spontaneous abortion (RSA) is a common cause of infertility, but previous attempts at identifying RSA causative genes have been relatively unsuccessful. Such failure to describe RSA aetiological genes might be explained by the fact that reproductive phenotypes should be considered as quantitative traits resulting from the intricate interaction of numerous genetic, epigenetic and environmental factors. Here, we studied an interspecific recombinant congenic strain (IRCS) of Mus musculus from the C57BL6/J strain of mice harbouring an approximate 5 Mb DNA fragment from chromosome 13 from Mus spretus mice (66H-MMU13 strain), with a high rate of embryonic resorption (ER)...
October 2016: Open Biology
https://www.readbyqxmd.com/read/27793960/u-s-food-and-drug-administration-approval-cabozantinib-for-treatment-of-advanced-renal-cell-carcinoma
#7
Harpreet Singh, Michael Brave, Julia A Beaver, Joyce Cheng, Shenghui Tang, Eias Zahalka, Todd R Palmby, Rajesh Venugopal, Pengfei Song, Qi Liu, Chao Liu, Jingyu Yu, Xiao Hong Chen, Xing Wang, Yaning Wang, Paul G Kluetz, Selena R Daniels, Elektra J Papadopoulos, Rajeshwari Sridhara, Amy E McKee, Amna Ibrahim, Geoffrey Kim, Richard Pazdur
On April 25, 2016, the U. S. Food and Drug Administration (FDA) approved cabozantinib (CABOMETYX{trade mark, serif}, Exelixis, Inc.) for the treatment of advanced renal cell carcinoma (RCC) in patients who have received prior anti-angiogenic therapy. The approval was based on data from one randomized, open-label, multicenter study in which RCC patients who had received prior anti-angiogenic therapy were treated with either cabozantinib 60 mg orally once daily (N=330) or everolimus 10 mg orally once daily (N=328)...
October 28, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27739558/comparing-ranibizumab-monotherapy-and-combination-with-single-photodynamic-therapy-in-wet-amd-retreatment-and-morphologic-results
#8
Katja Hatz, Ulrike Schneider, Bernhard Henrich, Beatrice Braun, Stefan Sacu, Christian Prünte
PURPOSE: To evaluate retreatment indications/morphologic responses to ranibizumab monotherapy and combination with verteporfin photodynamic therapy (PDT). METHODS: A total of 40 patients received 3 monthly intravitreal ranibizumab 0.3 mg injections combined with either PDT or sham PDT at baseline (1:1) followed by as-needed ranibizumab based on predetermined vision/anatomical criteria. RESULTS: Retreatment criteria were visual acuity (VA) loss (59%/58%), central retinal thickness (CRT) increase (27%/26%), or both (14%/16%)...
October 13, 2016: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/27731748/ofatumumab-plus-fludarabine-and-cyclophosphamide-in-relapsed-chronic-lymphocytic-leukemia-results-from-the-complement-2-trial
#9
Tadeusz Robak, Krzysztof Warzocha, K Govind Babu, Yaroslav Kulyaba, Kazimierz Kuliczkowski, Kudrat Abdulkadyrov, Javier Loscertales, Iryna Kryachok, Janusz Kłoczko, Grygoriy Rekhtman, Wojciech Homenda, Jerzy Z Błoński, Astrid McKeown, Michele M Gorczyca, Jodi L Carey, Chai-Ni Chang, Steen Lisby, Ira V Gupta, Sebastian Grosicki
: In this multicenter, open-label, phase III study, patients with relapsed chronic lymphocytic leukemia (CLL) were randomized (1:1) to receive ofatumumab plus fludarabine and cyclophosphamide (OFA + FC) or FC alone; the primary endpoint being progression-free survival (PFS) assessed by an independent review committee (IRC). Between March 2009 and January 2012, 365 patients were randomized (OFA + FC: n = 183; FC: n = 182). Median IRC-assessed PFS was 28.9 months with OFA + FC versus 18...
October 12, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27724149/investigator-and-independent-review-committee-exploratory-assessment-and-verification-of-tumor-response-in-a-non-hodgkin-lymphoma-study
#10
Robert R Ford, Robert W Ford, Michael O'Neal, Brad S Kahl, Ling Chen, Mihaela Munteanu, Bruce D Cheson
Interpretation of endpoints (e.g. overall response rate) in clinical trials depends on the accurate and reliable measurement and identification of tumors. Regulatory agencies recommend blinded reviews of imaging data by independent review committees (IRCs). Differences in response outcomes that arise between IRCs and site investigators raise regulatory/sponsor concerns. Here, we evaluate discrepant tumor response assessments by the IRC and unblinded investigators (complete versus partial response, respectively) occurring in 52 (13% of 393 IRC-assessed responders) of 447 enrolled patients with treatment-naïve non-Hodgkin lymphoma from a randomized study...
October 10, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27718576/revisiting-the-dielectric-constant-effect-on-the-nucleophile-and-leaving-group-of-prototypical-backside-sn2-reactions-a-reaction-force-and-atomic-contribution-analysis
#11
Laura Milena Pedraza-González, Johan Fabian Galindo, Ronald Gonzalez, Andrés Reyes
The solvent effect on the nucleophile and leaving group atoms of the prototypical F(-) + CH3Cl → CH3F + Cl(-) backside bimolecular nucleophilic substitution reaction (SN2) is analyzed employing the reaction force and the atomic contributions methods on the intrinsic reaction coordinate (IRC). Solvent effects were accounted for using the polarizable continuum solvent model. Calculations were performed employing eleven dielectric constants, ε, ranging from 1.0 to 78.5, to cover a wide spectrum of solvents...
October 9, 2016: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/27688874/medical-education-in-israel-2016-five-medical-schools-in-in-a-period-of-transition
#12
Shmuel Reis, Jacob Urkin, Rachel Nave, Rosalie Ber, Amitai Ziv, Orit Karnieli-Miller, Dafna Meitar, Peter Gilbey, Dror Mevorach
ABSTRACT: We reviewed the existing programs for basic medical education (BME) in Israel as well as their output, since they are in a phase of reassessment and transition. The transition has been informed, in part, by evaluation in 2014 by an International Review Committee (IRC). The review is followed by an analysis of its implications as well as the emergent roadmap for the future. The review documents a trend of modernizing, humanizing, and professionalizing Israeli medical education in general, and BME in particular, independently in each of the medical schools...
2016: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/27687474/embryo-larval-exposure-to-atrazine-reduces-viability-and-alters-oxidative-stress-parameters-in-drosophila-melanogaster
#13
Fernanda Hernandes Figueira, Lais Mattos de Aguiar, Carlos Eduardo da Rosa
The herbicide atrazine has been used worldwide with subsequent residual contamination of water and food, which may cause adverse effects on non-target organisms. Animal exposure to this herbicide may affect development, reproduction and energy metabolism. Here, the effects of atrazine regarding survival and redox metabolism were assessed in the fruit fly D. melanogaster exposed during embryonic and larval development. The embryos (newly fertilized eggs) were exposed to different atrazine concentrations (10μM and 100μM) in the diet until the adult fly emerged...
September 27, 2016: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/27680671/survival-and-failure-modes-platform-switching-for-internal-and-external-hexagon-cemented-fixed-dental-prostheses
#14
Rodolfo B Anchieta, Lucas S Machado, Ronaldo Hirata, Paulo G Coelho, Estevam A Bonfante
This study evaluated the probability of survival (reliability) of platform-switched fixed dental prostheses (FDPs) cemented on different implant-abutment connection designs. Eighty-four-three-unit FDPs (molar pontic) were cemented on abutments connected to two implants of external or internal hexagon connection. Four groups (n = 21 each) were established: external hexagon connection and regular platform (ERC); external hexagon connection and switched platform (ESC); internal hexagon and regular platform (IRC); and internal hexagon and switched platform (ISC)...
October 2016: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/27673598/potential-energy-surface-based-automatic-deduction-of-conformational-transition-networks-and-its-application-on-quantum-mechanical-landscapes-of-d-glucose-conformers
#15
Hiroko Satoh, Tomohiro Oda, Kumiyo Nakakoji, Takeaki Uno, Hiroaki Tanaka, Satoru Iwata, Koichi Ohno
This paper describes our approach that is built upon the potential energy surface (PES)-based conformational analysis. This approach automatically deduces a conformational transition network, called a conformational reaction route map (r-map), by using the Scaled Hypersphere Search of the Anharmonic Downward Distortion Following method (SHS-ADDF). The PES-based conformational search has been achieved by using large ADDF, which makes it possible to trace only low transition state (TS) barriers while restraining bond lengths and structures with high free energy...
October 5, 2016: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/27671039/resveratrol-promotes-myenteric-neuroprotection-in-the-ileum-of-rats-after-ischemia-reperfusion-injury
#16
Stephanie Carvalho Borges, Aline Cristine da Silva de Souza, Evandro José Beraldi, Larissa Carla Lauer Schneider, Nilza Cristina Buttow
AIMS: The present study evaluated the effects of resveratrol in the myenteric plexus after intestinal ischemia-reperfusion (I/R) injury caused by occluding the superior mesenteric artery for 45min, followed by 7days of reperfusion. MAIN METHODS: Forty-two male Wistar rats were divided into seven groups: control (C group), untreated sham surgery control (SC group), sham surgery control treated with resveratrol before surgery (STA group), sham surgery control treated with resveratrol before and after surgery (STAD group), ischemic control (IRC group), ischemic treated before I/R (IRTA group), and ischemic treated before and after I/R (IRTAD group)...
September 23, 2016: Life Sciences
https://www.readbyqxmd.com/read/27651104/dynamical-bifurcation-in-gas-phase-xh-ch3-y-sn-2-reactions-the-role-of-energy-flow-and-redistribution-in-avoiding-the-minimum-energy-path
#17
Yaicel G Proenza, Miguel A F de Souza, Ricardo L Longo
The gas-phase reactions of XH(-) (X=O, S) + CH3 Y (Y=F, Cl, Br) span nearly the whole range of SN 2 pathways, and show an intrinsic reaction coordinate (IRC) (minimum energy path) with a deep well owing to the CH3 XH⋅⋅⋅Y(-) (or CH3 S(-) ⋅⋅⋅HF) hydrogen-bonded postreaction complex. MP2 quasiclassical-type direct dynamics starting at the [HX⋅⋅⋅CH3 ⋅⋅⋅Y](-) transition-state (TS) structure reveal distinct mechanistic behaviors. Trajectories that yield the separated CH3 XH+Y(-) (or CH3 S(-) +HF) products directly are non-IRC, whereas those that sample the CH3 XH⋅⋅⋅Y(-) (or CH3 S(-) ⋅⋅⋅HF) complex are IRC...
November 2, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27617373/clinical-performance-of-indirect-composite-onlays-as-esthetic-alternative-to-stainless-steel-crowns-for-rehabilitation-of-a-large-carious-primary-molar
#18
Hitesh Chander Mittal, Ashima Goyal, Krishan Gauba, Aditi Kapur
OBJECTIVE: The aim of the present study was to evaluate the clinical performance of indirect resin composite onlays (IRC onlay) compared to stainless steel crowns (SSCs), as an esthetic alternative for rehabilitation of extensively carious primary molars. STUDY DESIGN: Fifty pediatric patients each received either IRC onlay or SSC randomly on extensively carious endodontically treated primary molars. All the restorations were evaluated at baseline and then every 6 months till 36 months using 'modified FDI criteria' for retention, marginal integrity, occlusion, proximal contact, secondary caries and gingival health...
2016: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/27613874/t-cell-subsets-an-immunological-biomarker-to-predict-progression-to-clinical-arthritis-in-acpa-positive-individuals
#19
L Hunt, E M Hensor, J Nam, A N Burska, R Parmar, P Emery, F Ponchel
OBJECTIVES: Anticitrullinated protein antibody (ACPA)+ individuals with non-specific musculoskeletal symptoms are at risk of inflammatory arthritis (IA). This study aims to demonstrate the predictive value of T cell subset quantification for progression towards IA and compare it with previously identified clinical predictors of progression. METHODS: 103 ACPA+ individuals without clinical synovitis were observed 3-monthly for 12 months and then as clinically indicated...
October 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27493290/non-invasive-magnetic-resonance-imaging-diagnosis-of-presumed-intermedioradial-carpal-bone-avascular-necrosis-in-the-dog
#20
Sarah L Pownder, Stacy Cooley, Kei Hayashi, Abraham Bezuidenhout, Matthew F Koff, Hollis G Potter
A 5-year-old, spayed female Weimaraner dog was evaluated for progressive left forelimb lameness localized to the carpus. Magnetic resonance imaging (MRI) was used to arrive at a presumptive diagnosis of intermedioradial carpal (IRC) bone fracture with avascular necrosis (AVN). To the authors' knowledge, this is the first report of naturally occurring AVN of the canine IRC diagnosed using MRI.
August 2016: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
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