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https://www.readbyqxmd.com/read/28642558/no-differences-in-longevity-of-direct-and-indirect-composite-restorations
#1
Marie A Congiusta
Data sourcesMedline, Cochrane Library, Web of Science, Scopus, Latin American and Caribbean Health Sciences (LILACS), Brazilian Library of Dentistry (BBO), clinicaltrials.gov and SIGLE databases.Study selectionOnly randomised clinical trials were considered that compared direct vs indirect composite restorations, with or without cusp involvement, having a follow-up period of two years or greater.Data extraction and synthesisTwo reviewers selected studies for inclusion, abstracted data and assessed risk of bias...
June 23, 2017: Evidence-based Dentistry
https://www.readbyqxmd.com/read/28637536/mental-health-morbidity-among-people-subject-to-immigration-detention-in-the-uk-a-feasibility-study
#2
P Sen, J Arugnanaseelan, E Connell, C Katona, A A Khan, P Moran, K Robjant, K Slade, J Tan, K Widyaratna, J Youd, A Forrester
AIMS: The UK has one of the largest systems of immigration detention in Europe.. Those detained include asylum-seekers and foreign national prisoners, groups with a higher prevalence of mental health vulnerabilities compared with the general population. In light of little published research on the mental health status of detainees in immigration removal centres (IRCs), the primary aim of this study was to explore whether it was feasible to conduct psychiatric research in such a setting...
June 22, 2017: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/28631233/interval-robotic-cytoreduction-following-neoadjuvant-chemotherapy-in-advanced-ovarian-cancer
#3
Sarah A Ackroyd, Sajeena Thomas, Cynthia Angel, Richard Moore, Philip J Meacham, Brent DuBeshter
The objective of this study is to review our experience with robotic interval cytoreduction following neoadjuvant chemotherapy for advanced ovarian cancer. We retrospectively reviewed patients with advanced ovarian cancer treated with neoadjuvant chemotherapy (NAC) and interval robotic cytoreduction (IRC) between 2011 and 2016 at the University of Rochester Medical Center. Demographic information, chemotherapy treatment, operative results, and follow-up were extracted from medical records. Twenty-nine patients underwent IRC after a mean of 3...
June 19, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/28593697/on-the-accessible-reaction-channels-of-vinyl-gold-i-species-%C3%AF-and-%C3%AF-pathways
#4
Laura Nunes Dos Santos Comprido, Johannes E M N Klein, Gerald Knizia, Johannes Kästner, A Stephen K Hashmi
The potential of vinyl Au species to react either via a controlled π- or σ- pathway is demonstrated. This nomenclature is directly derived from the orbitals of the vinyl Au species leading to the newly formed bonds. When the π-bond of the vinyl Au intermediate is transformed into a σ-bond, we name it π-pathway, and a σ- to σ- transformation is named σ-pathway. Examples of reactions following these pathways are a Au-catalysed [3,3]-sigmatropic rearrangement and a protodeauration reaction. These reactions have been studied using intrinsic bond orbitals (IBOs) and allow for the clear identification of these pathways...
June 7, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28586945/low-dose-rate-brachytherapy-versus-cryotherapy-in-low-and-intermediate-risk-prostate-cancer
#5
Matthew M Gestaut, Wendi Cai, Shilpa Vyas, Belur J Patel, Salman A Hasan, Yolanda MunozMaldonado, Niloyjyoti Deb, Gregory Swanson
PURPOSE: Cryotherapy and brachytherapy are definitive local treatment options for low- to intermediate-risk prostate cancer. There are both prospective and retrospective data for brachytherapy, but the use of cryotherapy has been limited primarily to single-institution retrospective studies. Currently, no published evidence has compared low-dose-rate brachytherapy versus cryotherapy. METHODS AND MATERIALS: Institutional review board approval was obtained to conduct a retrospective chart review of consecutive patients treated at our institution from 1990 to 2012...
May 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28556660/chronology-of-ch%C3%A2-%C3%A2-%C3%A2-o-hydrogen-bonding-from-molecular-dynamics-studies-of-the-phosphoric-acid-catalyzed-allylboration-of-benzaldehyde
#6
Matthew N Grayson, Zhongyue Yang, K N Houk
CH···O hydrogen bonds involving formyl groups have been invoked as a crucial factor controlling many asymmetric transformations. We conducted quasi-classical direct molecular dynamics simulations on the phosphoric acid-catalyzed allylboration of benzaldehyde to understand the synergy between the phosphoric acid OH···O hydrogen bond and the secondary CH···O formyl hydrogen bond as the reaction occurs. In the gas phase, both the CH···O and OH···O hydrogen bonds are enhanced from reactants to transition states...
June 6, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28514900/a-qm-qtaim-detailed-look-at-the-watson-crick%C3%A2-wobble-tautomeric-transformations-of-the-2-aminopurine%C3%A2-pyrimidine-mispairs
#7
Ol'ha O Brovarets', Ivan S Voiteshenko, Horacio Pérez-Sánchez, Dmytro M Hovorun
This work is devoted to the careful QM/QTAIM analysis of the evolution of the basic physico-chemical parameters along the intrinsic reaction coordinate (IRC) of the biologically important 2AP∙T(WC)↔2AP∙T*(w) and 2AP·C*(WC)↔2AP·C(w) Watson-Crick(WC)↔wobble(w) tautomeric transformations obtained at each point of the IRC using original authors' methodology. Established profiles reflect the high similarity between the courses of these processes. Basing on the scrupulous analysis of the profiles of their geometric and electron-topological parameters it was established that the dipole-active WC↔w tautomerisations of the Watson-Crick-like 2AP∙T(WC) / 2AP·C*(WC) mispairs, stabilized by the two classical N3H···N1, N2H···O2 and one weak C6H···O4/N4 H-bonds, into the wobble 2AP∙T*(w)/ 2AP·C(w) base pairs, respectively, joined by the two classical N2H···N3 and O4/N4H···N1 H-bonds, proceed via the concerted stepwise mechanism through the sequential intrapair proton transfer and subsequent large-scale shifting of the bases relative each other, through the planar, highly stable, zwitterionic transition states stabilized by the participation of the four H-bonds - N1(+)H···O4(-)/N4(-), N1(+)H···N3(-), N2(+)H···N3(-) and N2(+)H···O2(-)...
May 18, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28472390/contra-v3-a-tool-to-identify-transcription-factor-binding-sites-across-species-update-2017
#8
Lukasz Kreft, Arne Soete, Paco Hulpiau, Alexander Botzki, Yvan Saeys, Pieter De Bleser
Transcription factors are important gene regulators with distinctive roles in development, cell signaling and cell cycling, and they have been associated with many diseases. The ConTra v3 web server allows easy visualization and exploration of predicted transcription factor binding sites (TFBSs) in any genomic region surrounding coding or non-coding genes. In this updated version, with a completely re-implemented user interface using latest web technologies, users can choose from nine reference organisms ranging from human to yeast...
May 4, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28469283/the-growth-of-carbon-chains-in-irc-10216-mapped-with-alma
#9
M Agúndez, J Cernicharo, G Quintana-Lacaci, A Castro-Carrizo, L Velilla Prieto, N Marcelino, M Guélin, C Joblin, J A Martín-Gago, C A Gottlieb, N A Patel, M C McCarthy
Linear carbon chains are common in various types of astronomical molecular sources. Possible formation mechanisms involve both bottom-up and top-down routes. We have carried out a combined observational and modeling study of the formation of carbon chains in the C-star envelope IRC +10216, where the polymerization of acetylene and hydrogen cyanide induced by ultraviolet photons can drive the formation of linear carbon chains of increasing length. We have used ALMA to map the emission of λ 3 mm rotational lines of the hydrocarbon radicals C2H, C4H, and C6H, and the CN-containing species CN, C3N, HC3N, and HC5N with an angular resolution of ~1″...
May 2017: Astronomy and Astrophysics
https://www.readbyqxmd.com/read/28460197/the-non-surgical-management-for-hemorrhoidal-disease-a-systematic-review
#10
REVIEW
G Cocorullo, R Tutino, N Falco, L Licari, G Orlando, T Fontana, C Raspanti, G Salamone, G Scerrino, G Gallo, M Trompetto, G Gulotta
The non-surgical treatments for hemorrhoids are cost and time-saving techniques usually performed in patients suffering early hemorrhoidal disease. The most used are rubber band ligation (RBL), injection sclerotherapy (IS), and infrared coagulation (IRC). We performed a systematic review in order to evaluate: do these procedures really help to avoid further more aggressive treatments? What are the common harms? What are the rare harms? How many recurrences there are? A total of 21 RCTs were included in this review: 12 on RBL, 4 on IRC and 5 on IS...
January 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/28433753/computational-image-analysis-for-prognosis-determination-in-dme
#11
Bianca S Gerendas, Hrvoje Bogunovic, Amir Sadeghipour, Thomas Schlegl, Georg Langs, Sebastian M Waldstein, Ursula Schmidt-Erfurth
In this pilot study, we evaluated the potential of computational image analysis of optical coherence tomography (OCT) data to determine the prognosis of patients with diabetic macular edema (DME). Spectral-domain OCT scans with fully automated retinal layer segmentation and segmentation of intraretinal cystoid fluid (IRC) and subretinal fluid of 629 patients receiving anti-vascular endothelial growth factor therapy for DME in a randomized prospective clinical trial were analyzed. The results were used to define 312 potentially predictive features at three timepoints (baseline, weeks 12 and 24) for best-corrected visual acuity (BCVA) at baseline and after one year used in a random forest prediction path...
April 19, 2017: Vision Research
https://www.readbyqxmd.com/read/28421390/ofatumumab-combined-with-chlorambucil-for-previously-untreated-chronic-lymphocytic-leukemia-a-phase-i-ii-open-label-study-in-japan
#12
Kiyohiko Hatake, Michinori Ogura, Kohichi Takada, Masafumi Taniwaki, Fanghong Zhang, Taizo Fujita, Kiyoshi Ando
Elderly/comorbid patients with chronic lymphocytic leukemia (CLL) require low-toxicity treatments. Internationally, the standard treatment for such patients is chlorambucil and an anti-CD20 therapy; however, chlorambucil is not approved in Japan. The aim of the present study was to evaluate the safety, efficacy and pharmacokinetics of ofatumumab in combination with chlorambucil in Japanese patients with previously untreated CLL who were inappropriate for fludarabine-based therapy. Ten patients were enrolled and treated in this study, all of whom received at least one dose of the study drugs...
April 18, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28403925/prevention-of-infertility-induced-by-ovarian-ischemia-reperfusion-injury-by-benidipine-in-rats-biochemical-gene-expression-histopathological-and-immunohistochemical-evaluation
#13
E Unlubilgin, B Suleyman, G Balci, R Atakan Al, M Cankaya, U Arslan Nayki, H Suleyman
INTRODUCTION: Benidipine has been reported to prevent the ischemia/reperfusion (I/R) damage in heart tissue and to suppress oxidant and proinflammatory cytokine production, increased by I/R. However, There was no information about the effects of benidipine on I/R injury in the ovary and the damage of I/R-induced infertility. OBJECTIVES: The aim of the study was to investigate the effects of benidipine on bilateral ovarian I/R injury and whether or not effective in the treatment of I/R-induced infertility in rats...
March 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/28402962/regeneration-of-cervical-reserve-cell-like-cells-from-human-induced-pluripotent-stem-cells-ipscs-a-new-approach-to-finding-targets-for-cervical-cancer-stem-cell-treatment
#14
Masakazu Sato, Kei Kawana, Katsuyuki Adachi, Asaha Fujimoto, Mitsuyo Yoshida, Hiroe Nakamura, Haruka Nishida, Tomoko Inoue, Ayumi Taguchi, Juri Ogishima, Satoko Eguchi, Aki Yamashita, Kensuke Tomio, Osamu Wada-Hiraike, Katsutoshi Oda, Takeshi Nagamatsu, Yutaka Osuga, Tomoyuki Fujii
Cervical reserve cells are epithelial progenitor cells that are pathologically evident as the origin of cervical cancer. Thus, investigating the characteristics of cervical reserve cells could yield insight into the features of cervical cancer stem cells (CSCs). In this study, we established a method for the regeneration of cervical reserve cell-like properties from human induced pluripotent stem cells (iPSCs) and named these cells induced reserve cell-like cells (iRCs). Approximately 70% of iRCs were positive for the reserve cell markers p63, CK5 and CK8...
June 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28390361/the-role-of-li-ions-in-the-gas-phase-dehydrohalogenation-and-dehydration-reactions-of-i-c3h7br-and-i-c3h7oh-molecules-studied-by-radiofrequency-guided-ion-beam-techniques-and-ab-initio-methods
#15
E López, J M Lucas, J de Andrés, M Albertí, J M Bofill, A Aguilar
Gas phase reactive collisions between lithium ions and i-C3H7X (X = Br, OH) molecules have been studied under single collision conditions in the center of mass (CM) 0.01-10.00 eV energy range using a radiofrequency-guided ion beam apparatus. Mass spectrometry analysis of the products did show the presence of [C3H6-Li](+), [HX-Li](+), C3H7(+), and C2H3(+) as well as of the [Li-i-C3H7Br](+) adduct while [Li-i-C3H7OH](+) was hardly detected. For all these reactive processes, the corresponding cross sections have been measured in absolute units as a function of the CM collision energy...
April 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28373262/impact-of-ibrutinib-dose-adherence-on-therapeutic-efficacy-in-patients-with-previously-treated-cll-sll
#16
Paul M Barr, Jennifer R Brown, Peter Hillmen, Susan O'Brien, Jacqueline C Barrientos, Nishitha M Reddy, Steven Coutre, Stephen P Mulligan, Ulrich Jaeger, Richard R Furman, Florence Cymbalista, Marco Montillo, Claire Dearden, Tadeusz Robak, Carol Moreno, John M Pagel, Jan A Burger, Samuel Suzuki, Juthamas Sukbuntherng, George Cole, Danelle F James, John C Byrd
Ibrutinib, an oral inhibitor of Bruton's tyrosine kinase (BTK), at a once-daily dose of 420 mg achieved BTK active-site occupancy in patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) that was maintained at 24 hours. It is unknown if intermittent interruption of ibrutinib therapy contributes to altered clinical outcomes. We therefore evaluated the effect of ibrutinib dose adherence on patient outcomes in the phase 3 RESONATE trial. The overall mean dose intensity (DI) was 95% with median treatment duration of ∼9 months...
May 11, 2017: Blood
https://www.readbyqxmd.com/read/28332090/disparities-in-the-clinical-evolution-of-anal-neoplasia-in-an-hiv-infected-cohort
#17
Edward R Cachay, Wollelaw Agmas, Wm Christopher Mathews
BACKGROUND: A recent meta-analysis suggested that anal intraepithelial neoplasia and invasive anal cancer are more prevalent among black men having sex with men (MSM). METHODS: We conducted a retrospective cohort of HIV-infected adult patients under care between 2001 and 2012. Disparities in clinical evolution of anal intraepithelial neoplasia to high-grade squamous intraepithelial lesion (HSIL) and invasive anal cancer were evaluated in a three-state Markov model adjusted for cytology misclassification...
March 23, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28329727/theoretical-study-on-the-alkylation-of-o-xylene-with-styrene-in-alcl3-ionic-liquid-catalytic-system
#18
Bobo Cao, Jiuyao Du, Ziping Cao, Haitao Sun, Xuejun Sun, Hui Fu
To explore sustainable catalysts with innovative mechanisms, the alkylation mechanism of o-xylene with styrene was studied using DFT method in AlCl3-ionic liquid catalytic system. The reaction pathway was consisted of CC coupling and a hydrogen shift, in which two transition states were found and further discussed. The reactive energy catalyzed by superelectrophilic AlCl2(+) (12.6kcal/mol) was distinctly lower than AlCl3 (43.0kcal/mol), which was determined as the rate-determining step. Mulliken charge along IRC gave a comprehensive understanding of charge distribution and electron transfer in dynamic progress...
March 6, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28320906/perspective-chemical-dynamics-simulations-of-non-statistical-reaction-dynamics
#19
REVIEW
Xinyou Ma, William L Hase
Non-statistical chemical dynamics are exemplified by disagreements with the transition state (TS), RRKM and phase space theories of chemical kinetics and dynamics. The intrinsic reaction coordinate (IRC) is often used for the former two theories, and non-statistical dynamics arising from non-IRC dynamics are often important. In this perspective, non-statistical dynamics are discussed for chemical reactions, with results primarily obtained from chemical dynamics simulations and to a lesser extent from experiment...
April 28, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28281456/insulin-resistance-in-systemic-lupus-erythematosus-patients-contributing-factors-and-relationship-with-subclinical-atherosclerosis
#20
Hiurma Sánchez-Pérez, Beatriz Tejera-Segura, Antonia de Vera-González, Alejandra González-Delgado, José Manuel Olmos, José Luis Hernández, Alfonso Corrales, Raquel López-Mejías, Miguel Angel González-Gay, Iván Ferraz-Amaro
OBJECTIVES: Insulin resistance (IR) plays a role in the increased cardiovascular risk of systemic lupus erythematosus (SLE) patients. This study aimed to determine the potential association of IR with disease activity, drug exposure and subclinical atherosclerosis in patients with SLE. METHODS: This cross-sectional study encompassed 87 non-diabetic SLE patients and 82 sex-matched controls. Insulin and C-peptide serum levels, IR indexes by homeostatic model assessment (HOMA2) (both insulin-based: HOMA2-IR, and with C-peptide: HOMA2-IR-C-peptide) and lipid profiles were assessed in patients and controls...
March 8, 2017: Clinical and Experimental Rheumatology
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