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https://www.readbyqxmd.com/read/28332090/disparities-in-the-clinical-evolution-of-anal-neoplasia-in-an-hiv-infected-cohort
#1
Edward R Cachay, Wollelaw Agmas, Wm Christopher Mathews
BACKGROUND: A recent meta-analysis suggested that anal intraepithelial neoplasia and invasive anal cancer are more prevalent among black men having sex with men (MSM). METHODS: We conducted a retrospective cohort of HIV-infected adult patients under care between 2001 and 2012. Disparities in clinical evolution of anal intraepithelial neoplasia to high-grade squamous intraepithelial lesion (HSIL) and invasive anal cancer were evaluated in a three-state Markov model adjusted for cytology misclassification...
March 23, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28329727/theoretical-study-on-the-alkylation-of-o-xylene-with-styrene-in-alcl3-ionic-liquid-catalytic-system
#2
Bobo Cao, Jiuyao Du, Ziping Cao, Haitao Sun, Xuejun Sun, Hui Fu
To explore sustainable catalysts with innovative mechanisms, the alkylation mechanism of o-xylene with styrene was studied using DFT method in AlCl3-ionic liquid catalytic system. The reaction pathway was consisted of CC coupling and a hydrogen shift, in which two transition states were found and further discussed. The reactive energy catalyzed by superelectrophilic AlCl2(+) (12.6kcal/mol) was distinctly lower than AlCl3 (43.0kcal/mol), which was determined as the rate-determining step. Mulliken charge along IRC gave a comprehensive understanding of charge distribution and electron transfer in dynamic progress...
March 6, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28320906/perspective-chemical-dynamics-simulations-of-non-statistical-reaction-dynamics
#3
REVIEW
Xinyou Ma, William L Hase
Non-statistical chemical dynamics are exemplified by disagreements with the transition state (TS), RRKM and phase space theories of chemical kinetics and dynamics. The intrinsic reaction coordinate (IRC) is often used for the former two theories, and non-statistical dynamics arising from non-IRC dynamics are often important. In this perspective, non-statistical dynamics are discussed for chemical reactions, with results primarily obtained from chemical dynamics simulations and to a lesser extent from experiment...
April 28, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28281456/insulin-resistance-in-systemic-lupus-erythematosus-patients-contributing-factors-and-relationship-with-subclinical-atherosclerosis
#4
Hiurma Sánchez-Pérez, Beatriz Tejera-Segura, Antonia de Vera-González, Alejandra González-Delgado, José Manuel Olmos, José Luis Hernández, Alfonso Corrales, Raquel López-Mejías, Miguel Angel González-Gay, Iván Ferraz-Amaro
OBJECTIVES: Insulin resistance (IR) plays a role in the increased cardiovascular risk of systemic lupus erythematosus (SLE) patients. This study aimed to determine the potential association of IR with disease activity, drug exposure and subclinical atherosclerosis in patients with SLE. METHODS: This cross-sectional study encompassed 87 non-diabetic SLE patients and 82 sex-matched controls. Insulin and C-peptide serum levels, IR indexes by homeostatic model assessment (HOMA2) (both insulin-based: HOMA2-IR, and with C-peptide: HOMA2-IR-C-peptide) and lipid profiles were assessed in patients and controls...
March 8, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28275348/cerebromatic-a-versatile-toolbox-for-spline-based-mri-template-creation
#5
Marko Wilke, Mekibib Altaye, Scott K Holland
Brain image spatial normalization and tissue segmentation rely on prior tissue probability maps. Appropriately selecting these tissue maps becomes particularly important when investigating "unusual" populations, such as young children or elderly subjects. When creating such priors, the disadvantage of applying more deformation must be weighed against the benefit of achieving a crisper image. We have previously suggested that statistically modeling demographic variables, instead of simply averaging images, is advantageous...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/28270035/bmi-1-promotes-self-renewal-of-radio-and-temozolomide-tmz-resistant-breast-cancer-cells
#6
Yanfang Yan, Ying Wang, Pengxin Zhao, Weiyuan Ma, Zhigang Hu, Kaili Zhang
Breast cancer is a hormone-dependent malignancy and is the most prevalent cause of cancer-related mortality among females. Radiation therapy and chemotherapy are common treatments of breast cancer. However, tumor relapse and metastasis following therapy are major clinical challenges. The importance of B-lymphoma Moloney murine leukemia virus insertion region-1 (BMI-1) was implicated in cell proliferation, stem cell maintenance, and tumor initiation. We established radio- and temozolomide (TMZ)-resistant (IRC-R) MCF-7 and MDA-MB-231 cell lines to investigate the mechanism involved in therapeutic resistance...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28266091/efficacy-and-safety-of-nivolumab-in-japanese-patients-with-advanced-or-recurrent-squamous-non-small-cell-lung-cancer
#7
Toyoaki Hida, Makoto Nishio, Naoyuki Nogami, Yuichiro Ohe, Hiroshi Nokihara, Hiroshi Sakai, Miyako Satouchi, Kazuhiko Nakagawa, Mitsuhiro Takenoyama, Hiroshi Isobe, Shiro Fujita, Hiroshi Tanaka, Koichi Minato, Toshiaki Takahashi, Makoto Maemondo, Koji Takeda, Hideo Saka, Koichi Goto, Shinji Atagi, Tomonori Hirashima, Naoki Sumiyoshi, Tomohide Tamura
Limited treatment options are available for stage IIIB/IV non-small cell lung cancer (NSCLC). Nivolumab, a programmed cell death-1 immune checkpoint inhibitor antibody, has been shown to be effective for the treatment of NSCLC. This study investigated the effectiveness and safety of nivolumab in Japanese patients with advanced or recurrent squamous NSCLC that progressed after platinum-containing chemotherapy. In this multicenter phase II study, patients were treated with nivolumab (3mg/kg, intravenously) every 2 weeks until progressive disease or unacceptable toxicity was seen...
March 7, 2017: Cancer Science
https://www.readbyqxmd.com/read/28251882/solid-phase-extraction-preconcentration-method-for-simultaneous-determination-of-cadmium-lead-and-nickel-in-poultry-supplements
#8
Jameel Ahmed Baig, Hina Daud Memon, Syed Ali Imran Bukhari, Tasneem Gul Kazi, Hassan Imran Afridi, Hafiz Muhammad Naseer, Latif Elci
A new simple, selective, and economical preconcentration method was developed for the determination of Cd, Pb, and Ni in poultry antibiotics and supplements. The proposed preconcentration procedure is based on SPE using 8-hydroxyquinoline and Amberlite IRC-50 resin as complex and adsorbent, respectively. The determination was carried out by microsample injection system (MIS) flame atomic absorption spectroscopy (FAAS). Several analytical parameters were examined, including pH, type of resin, amount of resin, type of eluent, eluent volume, flow rate, sample volume, and interference of diverse ions...
March 2, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28184097/the-abundance-of-c2h4-in-the-circumstellar-envelope-of-irc-10216
#9
J P Fonfría, K H Hinkle, J Cernicharo, M J Richter, M Agúndez, L Wallace
High spectral resolution mid-IR observations of ethylene (C2H4) towards the AGB star IRC+10216 were obtained using the Texas Echelon Cross Echelle Spectrograph (TEXES) at the NASA Infrared Telescope Facility (IRTF). Eighty ro-vibrational lines from the 10.5 µm vibrational mode ν7 with J ≲ 30 were detected in absorption. The observed lines are divided into two groups with rotational temperatures of 105 and 400 K (warm and hot lines). The warm lines peak at ≃ -14 km s(-1) with respect to the systemic velocity, suggesting that they are mostly formed outwards from ≃ 20R⋆...
February 1, 2017: Astrophysical Journal
https://www.readbyqxmd.com/read/28183846/association-between-quality-of-response-and-outcomes-in-patients-with-newly-diagnosed-mantle-cell-lymphoma-receiving-vr-cap-versus-r-chop-in-the-phase-iii-lym-3002-study
#10
Gregor Verhoef, Tadeusz Robak, Huiqiang Huang, Halyna Pylypenko, Noppadol Siritanaratkul, Juliana Pereira, Johannes Drach, Jiri Mayer, Rumiko Okamoto, Lixia Pei, Brendan Rooney, Andrew Cakana, Helgi van de Velde, Franco Cavalli
In the phase III LYM-3002 study comparing intravenous VR-CAP with R-CHOP in patients with newly-diagnosed, measurable stage II-IV mantle cell lymphoma, not considered, or ineligible for, transplant, median progression-free survival was significantly improved with VR-CAP (24.7 vs R-CHOP 14.4 months; P<0.001). This post-hoc analysis evaluated the association between the improved outcomes and quality of responses achieved with VR-CAP versus R-CHOP in LYM-3002. Patients were randomized to 6-8 21-day cycles of VR-CAP or R-CHOP...
February 9, 2017: Haematologica
https://www.readbyqxmd.com/read/28066525/the-effect-of-transfemoral-interface-design-on-gait-speed-and-risk-of-falls
#11
Jason T Kahle, Tyler D Klenow, William J Sampson, M Jason Highsmith
Falls and diminished walking capacity are impairments common in persons with transfemoral amputation (TFA). Reducing falls and optimizing walking capacity through such means as achieving a more normal gait speed and community ambulation should be considered when formulating the prosthetic prescription. Because walking capacity and balance confidence are compromised with TFA, these outcomes should be considered when evaluating interfaces for transfemoral prosthetic users. The purpose of this study was to compare the effect of TFA interface design on walking capacity and balance confidence A retrospective cohort design was utilized involving unilateral TFA patients who used ischial ramus containment (IRC) and High-Fidelity (HiFi) interfaces (independent variables)...
September 2016: Technology and Innovation
https://www.readbyqxmd.com/read/28065983/herschel-hifi-observations-of-the-circumstellar-ammonia-lines-in-irc-10216
#12
M R Schmidt, J H He, R Szczerba, V Bujarrabal, J Alcolea, J Cernicharo, L Decin, K Justtanont, D Teyssier, K M Menten, D A Neufeld, H Olofsson, P Planesas, A P Marston, A M Sobolev, A de Koter, F L Schöier
CONTEXT: A discrepancy exists between the abundance of ammonia (NH3) derived previously for the circumstellar envelope (CSE) of IRC+10216 from far-IR submillimeter rotational lines and that inferred from radio inversion or mid-infrared (MIR) absorption transitions. AIMS: To address the discrepancy described above, new high-resolution far-infrared (FIR) observations of both ortho- and para-NH3 transitions toward IRC+10216 were obtained with Herschel, with the goal of determining the ammonia abundance and constraining the distribution of NH3 in the envelope of IRC+10216...
August 2016: Astronomy and Astrophysics
https://www.readbyqxmd.com/read/28056492/insights-into-the-interaction-of-high-potency-inhibitor-irc-083864-with-phosphatase-cdc25
#13
Manal Sarkis, Maria A Miteva, Maria Chiara Dasso Lang, Maryse Jaouen, Marie-Agnès Sari, Marie-Odile Galcéra, Mélanie Ethève-Quelquejeu, Christiane Garbay, Gildas Bertho, Emmanuelle Braud
CDC25 phosphatases play a crucial role in cell cycle regulation. They have been found to be over-expressed in various human tumours and to be valuable targets for cancer treatment. Here, we report the first model of binding of the most potent CDC25 inhibitor to date, the bis-quinone IRC-083864, into CDC25B obtained by combining molecular modeling and NMR studies. Our study provides new insights into key interactions of the catalytic site inhibitor and CDC25B in the absence of any available experimental structure of CDC25 with a bound catalytic site inhibitor...
January 5, 2017: Proteins
https://www.readbyqxmd.com/read/28047625/su-f-j-129-verification-of-geometric-and-dosimetric-accuracy-of-respiratory-management-systems-using-homemade-phantom
#14
E Goksel, H Kucucuk, O Senkesen, E Tezcanli
PURPOSE: Different placements of Infrared Cameras (IRC) in CT and treatment rooms can cause gating window level (GWL) variations leading to differences between GWL used for planning and treatments. Although, Varian Clinac DHX-OBI sytem and CT are equipped with the same kind of IRC, Truebeam STx (TB) has a different type of IRC known as banana type. In this study; geometric and dosimetric accuracy of respiratory management system (RPM) for different machines were investigated with a special homemade phantom...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28029244/stationary-conditions-of-the-electron-density-along-the-reaction-path-connection-with-conceptual-dft-and-information-theory
#15
Carlos A Gonzalez, Emilio Squitieri, Hector J Franco, Luis C Rincon
The Kohn-Sham density functional theory (DFT) formalism has been used to investigate the influence of the stationary behavior of the electron density (ρ(r⃗;s)) along a minimum energy path on the corresponding stationary conditions observed in the total potential energy of the reactive system, information theory measures (Shannon information entropy and Onicescu information energy), and chemical reactivity indexes (the chemical hardness). The theoretical treatment presented in this work, combined with DFT calculations on 3 different test reactions: Ḣ' + H2, Ḣ' + CH4 and H(-) + CH4, suggest that for any reactive system, properties that can be cast as a functional of the electron density, must exhibit stationary points along the IRC path modulated by the corresponding stationary behavior of the electron density...
January 17, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/27993793/vemurafenib-in-metastatic-melanoma-patients-with-brain-metastases-an-open-label-single-arm-phase-2-multicentre-study
#16
G A McArthur, M Maio, A Arance, P Nathan, C Blank, M-F Avril, C Garbe, A Hauschild, D Schadendorf, O Hamid, M Fluck, M Thebeau, J Schachter, R Kefford, M Chamberlain, M Makrutzki, S Robson, R Gonzalez, K Margolin
BACKGROUND: Vemurafenib has shown activity in patients with BRAF(V600) mutated melanoma with brain metastases (BM). This phase 2 study evaluated vemurafenib in patients with/without prior treatment for BM. METHODS: Patients with BRAF(V600) mutated melanoma with BM were enrolled into cohort 1 (previously untreated BM) and cohort 2 (previously treated BM) and received vemurafenib (960 mg BID) until disease progression (PD) or intolerance. Primary endpoint was best overall response rate (BORR) in the brain in cohort 1 that was evaluated using modified RECIST 1...
December 19, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27992248/deltoid-emg-is-reliable-during-submaximal-isometric-ramp-contractions
#17
David Phillips, Andrew Karduna
The EMG and load relationship is commonly measured with multiple submaximal isometric contractions. This method is both time consuming and may introduce fatigue. The purpose of this study was to determine if the electromyography (EMG) amplitude from the middle deltoid was reliable during isometric ramp contractions (IRCs) at different angles of elevation and rates of force application. Surface EMG was measured at three shoulder elevation angles during IRCs at four submaximal levels of maximum voluntary contraction (MVC)...
December 19, 2016: Journal of Applied Biomechanics
https://www.readbyqxmd.com/read/27951675/two-new-methods-to-generate-internal-coordinates-for-molecular-wave-packet-dynamics-in-reduced-dimensions
#18
Julius P P Zauleck, Sebastian Thallmair, Matthias Loipersberger, Regina de Vivie-Riedle
The curse of dimensionality still remains as the central challenge of molecular quantum dynamical calculations. Either compromises on the accuracy of the potential landscape have to be made or methods must be used that reduce the dimensionality of the configuration space of molecular systems to a low dimensional one. For dynamic approaches such as grid-based wave packet dynamics that are confined to a small number of degrees of freedom this dimensionality reduction can become a major part of the overall problem...
December 13, 2016: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/27892571/the-reaction-fragility-spectrum
#19
Ludwik Komorowski, Piotr Ordon, Mateusz Jędrzejewski
We report an original method that provides a new insight into the reaction mechanism by direct observation of bond breaking and formation. Variations of the diagonal elements of the Hessian along the IRC are shown to reflect the anharmonic properties of the system that are induced by electron density modifications upon the reaction. This information is presented in the form of the reaction spectrum, demonstrating how particular atoms engage in the reorganization of bonds. The test reactions are: HCOF synthesis and HONS isomerization...
December 7, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27890838/preoperative-evaluation-of-the-renal-function-before-the-treatment-of-abdominal-aortic-aneurysms
#20
Raphael Coscas, Sandra Wagner, Eve Vilaine, Albane Sartorius, Isabelle Javerliat, Olivier Goeau-Brissonniere, Marc Coggia, Ziad Massy
OBJECTIVES: Chronic impaired renal function (IRC) constitutes a major risk factor of morbi-mortality during the treatment of an abdominal aortic aneurism (AAA). The inflammatory state due to the AAA could result in a reduction in the muscular mass and an over-estimation of the glomerular filtration rate (GFR) with the usual formulas. The objective of this study was to determine if the formulae used to evaluate the estimated GFR were adapted in patients with AAA. MATERIALS AND METHODS: Between August 2013 and November 2014, we conducted an exploratory study to evaluate the renal function before surgery for AAA in 28 patients...
November 24, 2016: Annals of Vascular Surgery
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