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https://www.readbyqxmd.com/read/28813577/spatial-correspondence-between-intraretinal-fluid-subretinal-fluid-and-pigment-epithelial-detachment-in-neovascular-age-related-macular-degeneration
#1
Sophie Klimscha, Sebastian M Waldstein, Thomas Schlegl, Hrvoje Bogunovic, Amir Sadeghipour, Ana-Maria Philip, Dominika Podkowinski, Eleonore Pablik, Li Zhang, Michael D Abramoff, Milan Sonka, Bianca S Gerendas, Ursula Schmidt-Erfurth
Purpose: To identify the spatial distribution of exudative features of choroidal neovascularization in neovascular age-related macular degeneration (nAMD) based on the localization of intraretinal cystoid fluid (IRC), subretinal fluid (SRF), and pigment-epithelial detachment (PED). Methods: This retrospective cross-sectional study included spectral-domain optical coherence tomography volume scans (6 × 6 mm) of 1341 patients with treatment-naïve nAMD. IRC, SRF, and PED were detected on a per-voxel basis using fully automated segmentation algorithms...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28753502/isoconversional-approach-for-non-isothermal-decomposition-of-un-irradiated-and-photon-irradiated-5-fluorouracil
#2
Hala Sh Mohamed, AbdelRahman A Dahy, Refaat M Mahfouz
Kinetic analysis for the non-isothermal decomposition of un-irradiated and photon-beam-irradiated 5-fluorouracil (5-FU) as anti-cancer drug, was carried out in static air. Thermal decomposition of 5-FU proceeds in two steps. One minor step in the temperature range of (270-283°C) followed by the major step in the temperature range of (285-360°C). The non-isothermal data for un-irradiated and photon-irradiated 5-FU were analyzed using linear (Tang) and non-linear (Vyazovkin) isoconversional methods. The results of the application of these free models on the present kinetic data showed quite a dependence of the activation energy on the extent of conversion...
May 13, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28747763/efficacy-and-safety-of-very-early-mobilization-in-patients-with-acute-stroke-a-systematic-review-and-meta-analysis
#3
Tao Xu, Xinyuan Yu, Shu Ou, Xi Liu, Jinxian Yuan, Yangmei Chen
Whether very early mobilization (VEM) improves outcomes in stroke patients and reduces immobilization-related complications (IRCs) is currently unknown. The objective of this systematic review and meta-analysis was to evaluate the efficacy and safety of VEM in acute stroke patients following admission. Medline, Embase, and Cochrane Central Register of Controlled Trials databases were searched for randomized controlled trials (RCTs) that examined the efficacy or safety of VEM in patients with acute stroke. VEM was defined as out of bed activity commencing within 24 or 48 hours after the onset of stroke...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28731871/online-family-problem-solving-for-pediatric-traumatic-brain-injury-influences-of-parental-marital-status-and-participation-on-adolescent-outcomes
#4
Stacey P Raj, Nanhua Zhang, Michael W Kirkwood, H Gerry Taylor, Terry Stancin, Tanya M Brown, Shari L Wade
OBJECTIVE: To examine the moderating effects of parent marital status and participation on efficacy of an online family problem-solving intervention for pediatric traumatic brain injury (TBI). METHODS: Participants were 132 adolescents (12-17 years) who had sustained a recent (<6 months) TBI and their parents. Participants were randomly assigned to the intervention (Counselor-Assisted Problem Solving, CAPS) or an Internet resource comparison (IRC) condition. CAPS was designed to support families in the initial phase following TBI, by teaching problem-solving skills and addressing common challenges...
July 20, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28726900/potential-energy-surface-stationary-points-and-dynamics-of-the-f-ch3i-double-inversion-mechanism
#5
Yong-Tao Ma, Xinyou Ma, Anyang Li, Hua Guo, Li Yang, Jiaxu Zhang, William L Hase
Direct dynamics simulations were performed to study the SN2 double inversion mechanism SN2-DI, with retention of configuration, for the F(-) + CH3I reaction. Previous simulations identified a transition state (TS) structure, i.e. TS0, for the SN2-DI mechanism, including a reaction path. However, intrinsic reaction coordinate (IRC) calculations from TS0 show it is a proton transfer (PT) TS connected to the F(-)HCH2I SN2 pre-reaction complex and the FHCH2I(-) proton transfer post-reaction complex. Inclusion of TS0 in the SN2-DI mechanism would thus involve non-IRC atomistic dynamics...
July 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28724636/predictive-imaging-biomarkers-relevant-for-functional-and-anatomical-outcomes-during-ranibizumab-therapy-of-diabetic-macular-oedema
#6
Bianca S Gerendas, Sonja Prager, Gabor Deak, Christian Simader, Jan Lammer, Sebastian M Waldstein, Tadhg Guerin, Michael Kundi, Ursula Margarethe Schmidt-Erfurth
BACKGROUND/AIMS: The objective is to identify imaging biomarkers in optical coherence tomography predicting functional/anatomical outcomes in diabetic macular oedema (DMO). METHODS: The presented study is a post hoc analysis of the RESTORE/RESTORE-extension studies. Best-corrected visual acuity (BCVA) was analysed using general estimating equation models using treatment group/morphological features as predictor variables. In addition, linear multiple regression models analysed BCVA gain up to 12 and 36 months with BCVA/morphological baseline characteristics as independent predictor variables...
July 19, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28718926/ets-nocv-decomposition-of-the-reaction-force-the-hcn-cnh-isomerization-reaction-assisted-by-water
#7
Silvia Díaz, Mateusz Z Brela, Soledad Gutiérrez-Oliva, Alejandro Toro-Labbé, Artur Michalak
The partitioning of the reaction force based on the extended-transition-state natural orbital for chemical valence (ETS-NOCV) scheme has been proposed. This approach, together with the analysis of reaction electronic flux (REF), has been applied in a description of the changes in the electronic structure along the IRC pathway for the HCN/CNH isomerization reaction assisted by water. Two complementary ways of partitioning the system into molecular fragments have been considered ("reactant perspective" and "product perspective")...
September 15, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/28689043/pooled-systemic-efficacy-and-safety-data-from-the-pivotal-phase-ii-studies-np28673-and-np28761-of-alectinib-in-alk-positive-non-small-cell-lung-cancer
#8
James Chih-Hsin Yang, Sai-Hong Ignatius Ou, Luigi De Petris, Shirish Gadgeel, Leena Gandhi, Dong-Wan Kim, Fabrice Barlesi, Ramaswamy Govindan, Anne-Marie C Dingemans, Lucio Crino, Herve Lena, Sanjay Popat, Jin Seok Ahn, Eric Dansin, Sophie Golding, Walter Bordogna, Bogdana Balas, Peter N Morcos, Ali Zeaiter, Alice T Shaw
INTRODUCTION: Alectinib demonstrated clinical efficacy and an acceptable safety profile in two phase II studies (NP28761 and NP28673). Here we report pooled efficacy and safety data after 15 and 18 months' longer follow-up than the respective primary analyses. MATERIALS AND METHODS: Enrolled patients had ALK-positive NSCLC and had progressed on, or were intolerant to, crizotinib. Patients received oral alectinib 600 mg twice daily. The primary endpoint in both studies was objective response rate (ORR) assessed by an independent review committee (IRC) using Response Evaluation Criteria in Solid Tumors (RECIST v1...
July 5, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28642558/no-differences-in-longevity-of-direct-and-indirect-composite-restorations
#9
Marie A Congiusta
Data sourcesMedline, Cochrane Library, Web of Science, Scopus, Latin American and Caribbean Health Sciences (LILACS), Brazilian Library of Dentistry (BBO), clinicaltrials.gov and SIGLE databases.Study selectionOnly randomised clinical trials were considered that compared direct vs indirect composite restorations, with or without cusp involvement, having a follow-up period of two years or greater.Data extraction and synthesisTwo reviewers selected studies for inclusion, abstracted data and assessed risk of bias...
June 23, 2017: Evidence-based Dentistry
https://www.readbyqxmd.com/read/28637536/mental-health-morbidity-among-people-subject-to-immigration-detention-in-the-uk-a-feasibility-study
#10
P Sen, J Arugnanaseelan, E Connell, C Katona, A A Khan, P Moran, K Robjant, K Slade, J Tan, K Widyaratna, J Youd, A Forrester
AIMS: The UK has one of the largest systems of immigration detention in Europe.. Those detained include asylum-seekers and foreign national prisoners, groups with a higher prevalence of mental health vulnerabilities compared with the general population. In light of little published research on the mental health status of detainees in immigration removal centres (IRCs), the primary aim of this study was to explore whether it was feasible to conduct psychiatric research in such a setting...
June 22, 2017: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/28631233/interval-robotic-cytoreduction-following-neoadjuvant-chemotherapy-in-advanced-ovarian-cancer
#11
Sarah A Ackroyd, Sajeena Thomas, Cynthia Angel, Richard Moore, Philip J Meacham, Brent DuBeshter
The objective of this study is to review our experience with robotic interval cytoreduction following neoadjuvant chemotherapy for advanced ovarian cancer. We retrospectively reviewed patients with advanced ovarian cancer treated with neoadjuvant chemotherapy (NAC) and interval robotic cytoreduction (IRC) between 2011 and 2016 at the University of Rochester Medical Center. Demographic information, chemotherapy treatment, operative results, and follow-up were extracted from medical records. Twenty-nine patients underwent IRC after a mean of 3...
June 19, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/28593697/on-the-accessible-reaction-channels-of-vinyl-gold-i-species-%C3%AF-and-%C3%AF-pathways
#12
Laura Nunes Dos Santos Comprido, Johannes E M N Klein, Gerald Knizia, Johannes Kästner, A Stephen K Hashmi
The potential of vinyl Au species to react either through a controlled π- or σ-pathway is demonstrated. This nomenclature is directly derived from the orbitals of the vinyl Au species leading to the newly formed bonds. When the π-bond of the vinyl Au intermediate is transformed into a σ-bond, we name it π-pathway, and a σ- to σ- transformation is named σ-pathway. Examples of reactions following these pathways are a Au-catalysed [3,3]-sigmatropic rearrangement and a protodeauration reaction. These reactions have been studied using intrinsic bond orbitals (IBOs) and allow for the clear identification of these pathways...
June 7, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28586945/low-dose-rate-brachytherapy-versus-cryotherapy-in-low-and-intermediate-risk-prostate-cancer
#13
COMPARATIVE STUDY
Matthew M Gestaut, Wendi Cai, Shilpa Vyas, Belur J Patel, Salman A Hasan, Yolanda MunozMaldonado, Niloyjyoti Deb, Gregory Swanson
PURPOSE: Cryotherapy and brachytherapy are definitive local treatment options for low- to intermediate-risk prostate cancer. There are both prospective and retrospective data for brachytherapy, but the use of cryotherapy has been limited primarily to single-institution retrospective studies. Currently, no published evidence has compared low-dose-rate brachytherapy versus cryotherapy. METHODS AND MATERIALS: Institutional review board approval was obtained to conduct a retrospective chart review of consecutive patients treated at our institution from 1990 to 2012...
May 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28556660/chronology-of-ch%C3%A2-%C3%A2-%C3%A2-o-hydrogen-bonding-from-molecular-dynamics-studies-of-the-phosphoric-acid-catalyzed-allylboration-of-benzaldehyde
#14
Matthew N Grayson, Zhongyue Yang, K N Houk
CH···O hydrogen bonds involving formyl groups have been invoked as a crucial factor controlling many asymmetric transformations. We conducted quasi-classical direct molecular dynamics simulations on the phosphoric acid-catalyzed allylboration of benzaldehyde to understand the synergy between the phosphoric acid OH···O hydrogen bond and the secondary CH···O formyl hydrogen bond as the reaction occurs. In the gas phase, both the CH···O and OH···O hydrogen bonds are enhanced from reactants to transition states...
June 6, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28514900/a-qm-qtaim-detailed-look-at-the-watson-crick%C3%A2-wobble-tautomeric-transformations-of-the-2-aminopurine%C3%A2-pyrimidine-mispairs
#15
Ol'ha O Brovarets', Ivan S Voiteshenko, Horacio Pérez-Sánchez, Dmytro M Hovorun
This work is devoted to the careful QM/QTAIM analysis of the evolution of the basic physico-chemical parameters along the intrinsic reaction coordinate (IRC) of the biologically important 2AP∙T(WC)↔2AP∙T*(w) and 2AP·C*(WC)↔2AP·C(w) Watson-Crick(WC)↔wobble(w) tautomeric transformations obtained at each point of the IRC using original authors' methodology. Established profiles reflect the high similarity between the courses of these processes. Basing on the scrupulous analysis of the profiles of their geometric and electron-topological parameters it was established that the dipole-active WC↔w tautomerisations of the Watson-Crick-like 2AP∙T(WC) / 2AP·C*(WC) mispairs, stabilized by the two classical N3H···N1, N2H···O2 and one weak C6H···O4/N4 H-bonds, into the wobble 2AP∙T*(w)/ 2AP·C(w) base pairs, respectively, joined by the two classical N2H···N3 and O4/N4H···N1 H-bonds, proceed via the concerted stepwise mechanism through the sequential intrapair proton transfer and subsequent large-scale shifting of the bases relative each other, through the planar, highly stable, zwitterionic transition states stabilized by the participation of the four H-bonds - N1(+)H···O4(-)/N4(-), N1(+)H···N3(-), N2(+)H···N3(-) and N2(+)H···O2(-)...
May 18, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28472390/contra-v3-a-tool-to-identify-transcription-factor-binding-sites-across-species-update-2017
#16
Lukasz Kreft, Arne Soete, Paco Hulpiau, Alexander Botzki, Yvan Saeys, Pieter De Bleser
Transcription factors are important gene regulators with distinctive roles in development, cell signaling and cell cycling, and they have been associated with many diseases. The ConTra v3 web server allows easy visualization and exploration of predicted transcription factor binding sites (TFBSs) in any genomic region surrounding coding or non-coding genes. In this updated version, with a completely re-implemented user interface using latest web technologies, users can choose from nine reference organisms ranging from human to yeast...
May 4, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28469283/the-growth-of-carbon-chains-in-irc-10216-mapped-with-alma
#17
M Agúndez, J Cernicharo, G Quintana-Lacaci, A Castro-Carrizo, L Velilla Prieto, N Marcelino, M Guélin, C Joblin, J A Martín-Gago, C A Gottlieb, N A Patel, M C McCarthy
Linear carbon chains are common in various types of astronomical molecular sources. Possible formation mechanisms involve both bottom-up and top-down routes. We have carried out a combined observational and modeling study of the formation of carbon chains in the C-star envelope IRC +10216, where the polymerization of acetylene and hydrogen cyanide induced by ultraviolet photons can drive the formation of linear carbon chains of increasing length. We have used ALMA to map the emission of λ 3 mm rotational lines of the hydrocarbon radicals C2H, C4H, and C6H, and the CN-containing species CN, C3N, HC3N, and HC5N with an angular resolution of ~1″...
May 2017: Astronomy and Astrophysics
https://www.readbyqxmd.com/read/28460197/the-non-surgical-management-for-hemorrhoidal-disease-a-systematic-review
#18
REVIEW
G Cocorullo, R Tutino, N Falco, L Licari, G Orlando, T Fontana, C Raspanti, G Salamone, G Scerrino, G Gallo, M Trompetto, G Gulotta
The non-surgical treatments for hemorrhoids are cost and time-saving techniques usually performed in patients suffering early hemorrhoidal disease. The most used are rubber band ligation (RBL), injection sclerotherapy (IS), and infrared coagulation (IRC). We performed a systematic review in order to evaluate: do these procedures really help to avoid further more aggressive treatments? What are the common harms? What are the rare harms? How many recurrences there are? A total of 21 RCTs were included in this review: 12 on RBL, 4 on IRC and 5 on IS...
January 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/28433753/computational-image-analysis-for-prognosis-determination-in-dme
#19
Bianca S Gerendas, Hrvoje Bogunovic, Amir Sadeghipour, Thomas Schlegl, Georg Langs, Sebastian M Waldstein, Ursula Schmidt-Erfurth
In this pilot study, we evaluated the potential of computational image analysis of optical coherence tomography (OCT) data to determine the prognosis of patients with diabetic macular edema (DME). Spectral-domain OCT scans with fully automated retinal layer segmentation and segmentation of intraretinal cystoid fluid (IRC) and subretinal fluid of 629 patients receiving anti-vascular endothelial growth factor therapy for DME in a randomized prospective clinical trial were analyzed. The results were used to define 312 potentially predictive features at three timepoints (baseline, weeks 12 and 24) for best-corrected visual acuity (BCVA) at baseline and after one year used in a random forest prediction path...
April 19, 2017: Vision Research
https://www.readbyqxmd.com/read/28421390/ofatumumab-combined-with-chlorambucil-for-previously-untreated-chronic-lymphocytic-leukemia-a-phase-i-ii-open-label-study-in-japan
#20
Kiyohiko Hatake, Michinori Ogura, Kohichi Takada, Masafumi Taniwaki, Fanghong Zhang, Taizo Fujita, Kiyoshi Ando
Elderly/comorbid patients with chronic lymphocytic leukemia (CLL) require low-toxicity treatments. Internationally, the standard treatment for such patients is chlorambucil and an anti-CD20 therapy; however, chlorambucil is not approved in Japan. The aim of the present study was to evaluate the safety, efficacy and pharmacokinetics of ofatumumab in combination with chlorambucil in Japanese patients with previously untreated CLL who were inappropriate for fludarabine-based therapy. Ten patients were enrolled and treated in this study, all of whom received at least one dose of the study drugs...
August 2017: International Journal of Hematology
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