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PET-CT and large vessel vasculitis

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https://www.readbyqxmd.com/read/29690555/concomitant-polymyalgia-rheumatica-and-large-vessel-vasculitis-visualized-on-18-f-fdg-pet-ct
#1
Jane Maestri Brittain, Lars Christian Gormsen, Eric von Benzon, Kim Francis Andersen
Polymyalgia rheumatica (PMR) and large-vessel vasculitis (LVV) are related rheumatic diseases which are occasionally present concomitantly. PMR is characterized by synovitis and bursitis. In LVV, inflammation of the blood vessel wall is seen. Both disorders can be difficult to diagnose since patients often present non-specific symptoms and results of blood tests. The non-specific symptoms cannot always be distinguished from symptoms indicating an occult malignancy. We present a case of PMR and LVV in a Scandinavian man visualized on [18 F]-2-deoxy-D-glucose positron emission tomography/computed tomography (18 F-FDG PET/CT) with the presentation of typically affected sites of joints and arteries and with the same imaging modality ruling out occult malignancy...
April 22, 2018: Diagnostics
https://www.readbyqxmd.com/read/29671039/three-days-of-high-dose-glucocorticoid-treatment-attenuates-large-vessel-18f-fdg-uptake-in-large-vessel-giant-cell-arteritis-but-with-a-limited-impact-on-diagnostic-accuracy
#2
Berit Dalsgaard Nielsen, Lars Christian Gormsen, Ib Tønder Hansen, Kresten Krarup Keller, Philip Therkildsen, Ellen-Margrethe Hauge
PURPOSE: To evaluate the in-treatment diagnostic accuracy of FDG PET/CT in large-vessel giant cell arteritis (LV-GCA) by serial scans before and after a short course of high-dose glucocorticoid treatment. METHODS: Twenty-four glucocorticoid-naïve patients with new-onset PET/CT verified LV-GCA (pre-treatment baseline PET) were prospectively included. Excluded were patients with a previous history of GCA or polymyalgia rheumatica, LV-GCA-mimicking conditions and patients on immunosuppressive therapy...
April 18, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29550251/18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-patients-with-polymyalgia-rheumatica-screening-for-vasculitis
#3
Karla Arévalo Ruales, Rosa Negueroles Albuixech, José Loaiza Gongora, Elena Grau García, José Ivorra Cortés, José A Román Ivorra
OBJECTIVE: Polymyalgia rheumatica (PR) can be associated with large vessel vasculitis (LVV). We evaluate the diagnostic role of 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) and its impact on the treatment of LVV associated with PR. MATERIALS AND METHODS: Retrospective study of patients diagnosed with PR. Data was collected from health records. Blood analysis included acute-phase reactants (APR), C-reactive protein (CRP) and erythrocyte sedimentation rate...
March 14, 2018: Reumatología Clinica
https://www.readbyqxmd.com/read/29531788/imaging-in-diagnosis-outcome-prediction-and-monitoring-of-large-vessel-vasculitis-a-systematic-literature-review-and-meta-analysis-informing-the-eular-recommendations
#4
Christina Duftner, Christian Dejaco, Alexandre Sepriano, Louise Falzon, Wolfgang Andreas Schmidt, Sofia Ramiro
Objectives: To perform a systematic literature review on imaging techniques for diagnosis, outcome prediction and disease monitoring in large vessel vasculitis (LVV) informing the European League Against Rheumatism recommendations for imaging in LVV. Methods: Systematic literature review (until 10 March 2017) of diagnostic and prognostic studies enrolling >20 patients and investigating ultrasound, MRI, CT or positron emission tomography (PET) in patients with suspected and/or established primary LVV...
2018: RMD Open
https://www.readbyqxmd.com/read/29501403/extent-large-vessel-vasculitis-diagnosed-with-18-f-fdg-pet-ct
#5
V M Pachón-Garrudo, J J Martín-Marcuartu, Á de Bonilla-Damiá, J M Jiménez-Hoyuela-García
No abstract text is available yet for this article.
February 28, 2018: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/29430115/18f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-evaluation-of-large-vessel-vasculitis
#6
Amrutha Lakshmi Rayudu, Tekchand Kalawat, V S Krishna Mohan, A Mohan, Amancharla Yadagiri Lakshmi, Ranadheer Gupta Mantri
18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET-CT) is a rapidly evolving hybrid imaging technique in evaluation of infection and inflammation. Usually, functional changes often precede anatomical changes. 18F-FDG PET-CT, a noninvasive diagnostic test and it is useful for the early detection of inflammation. Most of the large vessel vasculitis patients present with nonspecific signs and symptoms, which are difficult to diagnose clinically. Here, we discuss three cases of large vessel vasculitis with different clinical presentations, identified by 18F-FDG PET-CT scan...
January 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29374655/symptomatic-lower-limb-large-vessel-vasculitis-presenting-as-fever-of-unknown-origin-diagnosed-on-fdg-pet-ct
#7
Angela Mujukian, Michael Kay, Jonathan Lewis Marks
No abstract text is available yet for this article.
January 26, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29362158/imaging-giant-cell-arteritis-and-aortitis-in-contrast-enhanced-18f-fdg-pet-ct-which-imaging-score-correlates-best-with-laboratory-inflammation-markers
#8
Susann-Cathrin Olthof, Patrick Krumm, Jörg Henes, Konstantin Nikolaou, Christian la Fougère, Christina Pfannenberg, Nina Schwenzer
PURPOSE: To define the most appropriate imaging parameters in combined Fluorodeoxyglucose (FDG) PET/CT reflecting the inflammatory burden in large vessel vasculitis. METHODS: Two readers retrospectively graded disease extent and activity in 17 LVV patients using visual and quantitative scores in FDG PET and contrast enhanced CT. Visual PET scores were assessed corresponding to FDG-uptake vs. liver uptake (score 0-3). CT visual scoring referred to the affected vessel extent (score 1-5)...
February 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29358285/eular-recommendations-for-the-use-of-imaging-in-large-vessel-vasculitis-in-clinical-practice
#9
Christian Dejaco, Sofia Ramiro, Christina Duftner, Florent L Besson, Thorsten A Bley, Daniel Blockmans, Elisabeth Brouwer, Marco A Cimmino, Eric Clark, Bhaskar Dasgupta, Andreas P Diamantopoulos, Haner Direskeneli, Annamaria Iagnocco, Thorsten Klink, Lorna Neill, Cristina Ponte, Carlo Salvarani, Riemer H J A Slart, Madeline Whitlock, Wolfgang A Schmidt
To develop evidence-based recommendations for the use of imaging modalities in primary large vessel vasculitis (LVV) including giant cell arteritis (GCA) and Takayasu arteritis (TAK). European League Against Rheumatism (EULAR) standardised operating procedures were followed. A systematic literature review was conducted to retrieve data on the role of imaging modalities including ultrasound, MRI, CT and [18 F]-fluorodeoxyglucose positron emission tomography (PET) in LVV. Based on evidence and expert opinion, the task force consisting of 20 physicians, healthcare professionals and patients from 10 EULAR countries developed recommendations, with consensus obtained through voting...
May 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29166756/use-of-imaging-techniques-in-large-vessel-vasculitis-and-related-conditions
#10
Annibale Versari, Nicolò Pipitone, Massimiliano Casali, Francois Jamar, Giulia Pazzola
Giant cell arteritis (GCA) and Takayasu's arteritis (TA) are large vessel vasculitis (LVV) primarily affecting the aorta and its major branches, mainly differentiated by the onset age (>50 years GCA and <40 years TA). In addition, temporal artery involvement and polymyalgia rheumatica are typical features of GCA, but not TA. Imaging techniques are required to secure the diagnosis of large-vessel vasculitides, and to monitor the disease course. Both morphological and metabolic imaging are involved. Morphological imaging is represented mainly by computerized tomography (CT), CT angiography, magnetic resonance (MR), MR angiography, color-Doppler sonography (CDS) and high-resolution CDS...
March 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29145680/-a-rare-differential-diagnosis-of-chronic-cough
#11
Michael Dicker, Tino Schneider, Johannes von Kempis, Markus Diethelm
History and admission findings  We report on a 62-year-old male patient with dry cough for 3 months, constitutional symptoms and elevated inflammatory markers. Investigations  Despite extensive diagnostics no infectious, malignant or rheumatologic disease could be found. Bronchoscopy with bronchoalveolar lavage showed lymphocytosis. 18-FDG-PET/CT demonstrated increased metabolic activity of the aorta and its primary branches. Diagnosis, treatment and course  We diagnosed large vessel vasculitis consistent to a subtype of giant cell arteritis (GCA) without cranial manifestation...
November 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29017002/the-question-mark-sign-of-large-vessel-vasculitis-on-18f-fdg-pet-ct
#12
E J Teoh, K M Bradley
No abstract text is available yet for this article.
October 1, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28967430/-18-f-fdg-pet-ct-in-the-follow-up-of-large-vessel-vasculitis-a-study-of-37-consecutive-patients
#13
Isabel Martínez-Rodríguez, Mikel Jiménez-Alonso, Remedios Quirce, Julio Jiménez-Bonilla, Néstor Martínez-Amador, María De Arcocha-Torres, Javier Loricera, Ricardo Blanco, Miguel Á González-Gay, Ignacio Banzo
OBJECTIVE: 18 F-FDG PET/CT has proved to be of potential value for early diagnosis of large-vessel vasculitis (LVV), which frequently involves the aorta. However, its role in the follow-up of these patients has not been well established. Our aim was to evaluate the contribution of18 F-FDG PET/CT in this clinical situation. METHODS: This study included 37 consecutive patients (28 women, 66.5 ± 9.9 years) with an initial18 F-FDG PET/CT positive for LVV and a mean ± standard deviation follow-up PET/CT of 7...
February 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28928271/the-value-of-18-f-fdg-pet-ct-in-identifying-the-cause-of-fever-of-unknown-origin-fuo-and-inflammation-of-unknown-origin-iuo-data-from-a-prospective-study
#14
Verena Schönau, Kristin Vogel, Matthias Englbrecht, Jochen Wacker, Daniela Schmidt, Bernhard Manger, Torsten Kuwert, Georg Schett
BACKGROUND: Fever of unknown origin (FUO) and inflammation of unknown origin (IUO) are diagnostically challenging conditions. Diagnosis of underlying disease may be improved by18 F-fluorodesoxyglucose positron emission tomography (18 F-FDG-PET). METHODS: Prospective study to test diagnostic utility of18 F-FDG-PET/CT in a large cohort of patients with FUO or IUO and to define parameters that increase the likelihood of diagnostic18 F-FDG-PET/CT. Patients with FUO or IUO received18 F-FDG-PET/CT scanning in addition to standard diagnostic work-up...
January 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28899801/is-pet-ct-essential-in-the-diagnosis-and-follow-up-of-temporal-arteritis
#15
REVIEW
Carlo Salvarani, Alessandra Soriano, Francesco Muratore, Yehuda Shoenfeld, Daniel Blockmans
The increasing availability and improvement of imaging techniques are deeply influencing diagnosis and work-up of patients affected with vasculitis, particularly those with large vessel vasculitis (LVV). Fluorodeoxyglucose (18 F-FDG) positron emission tomography (PET), especially when integrated with computed tomography (CT), is taking hold as a useful diagnostic technique to examine the aorta and the other large vessels in giant cell arteritis (GCA) with concomitant large vessel involvement (LV-GCA). In this paper we examined the progresses performed in this field in the last twenty years and the evidence available so far according to two different points of view ('pros' and 'cons'), in order to give a comprehensive answer to a still open question about the role of PET/CT in the diagnosis and follow-up of GCA...
November 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28799318/giant-cell-arteritis-presenting-as-puo
#16
Sham Santhanam, Sampath Kumar Mani
Giant cell arteritis(GCA) is a primary granulomatous vasculitis affecting the large and medium sized arteries. We present here a case of GCA with pyrexia of unknown origin (PUO) as the presenting manifestation in the absence of other typical features. On evaluation, the patient had raised inflammatory markers with features of large vessel vasculitis on whole body PET-CT scan. The colour doppler ultrasonography(CDUS) of the temporal arteries showed bilateral halo sign. Since bilateral 'halo sign' is more specific for the diagnosis of GCA, temporal artery biopsy is not mandatory...
August 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28765420/lesson-of-the-month-1-large-vessel-vasculitis-a-diagnostic-challenge-and-the-role-of-18-fluorodeoxyglucose-positron-emission-tomography
#17
Andrew Allard, Ramesh Mootoo
Large vessel vasculitis can pose a significant diagnostic challenge. It may be insidious in onset with the only presenting symptoms consisting of constitutional compromise. It may mimic other pathologies and the only serological abnormalities may be abnormal inflammatory markers. Conventional imaging modalities may not be diagnostic. We present a case of large vessel vasculitis that proved a significant diagnostic challenge with diagnosis established on 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) computerised tomography (CT) imaging...
July 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28664283/-positron-emission-tomography-computed-tomography-in-rheumatology
#18
T Derlin
Combined positron emission tomography/computed tomography (PET/CT) is a whole-body imaging procedure, which enables sensitive detection of inflammatory changes. It may be used to simultaneously obtain both precise anatomical and molecular information in order to comprehensively characterize diseases. The glucose analogue (18)F-fluorodeoxyglucose (FDG) represents a universally applicable radiotracer for imaging of inflammatory processes. Its accumulation in tissues can be semiquantitatively characterized by use of standardized uptake values (SUV)...
September 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28583280/clinical-value-of-fdg-pet-ct-for-the-evaluation-of-rheumatic-diseases-rheumatoid-arthritis-polymyalgia-rheumatica-and-relapsing-polychondritis
#19
REVIEW
Kazuo Kubota, Hiroyuki Yamashita, Akio Mimori
FDG is a tracer for visualizing glucose metabolism. PET/CT using FDG is widely used for the diagnosis of cancer, because glycolysis is elevated in cancer cells. Similarly, active inflammatory tissue also exhibits elevated glucose metabolism because of glycolysis in activated macrophages and proliferating fibroblasts. Elevated FDG uptake by active inflammatory tissues, such as those affected by arthritis, vasculitis, lymphadenitis, and chondritis, has enabled the diagnosis of inflammatory diseases using FDG-PET/CT...
July 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28503707/the-value-of-ultrasound-in-diagnosing-extracranial-large-vessel-vasculitis-compared-to-fdg-pet-ct-a-retrospective-study
#20
Christian Löffler, Johannes Hoffend, Urs Benck, Bernhard K Krämer, Raoul Bergner
Large-vessel vasculitis (LVV) is a group of diseases mainly comprised of giant-cell arteritis (GCA), Takayasu arteritis, and a series of rare diseases like Behçet's disease, IgG4-related disease, infectious aortitis, and other unfrequent entities. Besides clinical and laboratory features, Doppler sonography (DS) can assist in establishing the diagnosis. Its diagnostic sensitivity has been evaluated in various studies, most of them, however, in temporal arteritis (TA) respectively in LVV with involvement of the temporal artery...
September 2017: Clinical Rheumatology
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