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Typical antipsychotics

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https://www.readbyqxmd.com/read/28096678/risperidone-improves-interpersonal-perception-and-executive-function-in-patients-with-schizophrenia
#1
Zhenhe Zhou, Yuanyuan Zhu, Jun Wang, Hongmei Zhu
OBJECTIVE: To investigate whether risperidone improves social cognitive impairments and executive dysfunction in people with schizophrenia. METHODS: Fifty-six patients who met the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, diagnostic criteria for schizophrenia were allocated to a risperidone treatment group (RTG, n=28) and a typical antipsychotic treatment group (TATG, n=28). Twenty-eight healthy volunteers were recruited as the normal control group (NCG)...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28078393/antipsychotic-use-is-a-risk-factor-for-hyponatremia-in-patients-with-schizophrenia-a-15-year-follow-up-study
#2
Hang-Ju Yang, Wan-Ju Cheng
RATIONALE: Hyponatremia affects 10% of patients with chronic schizophrenia and can lead to severe consequences. However, the role of antipsychotics and other risk factors in hyponatremia occurrence has remained inconsistent. OBJECTIVE: This study examined the association between antipsychotic use and hyponatremia occurrence in patients with schizophrenia. METHODS: We utilized the National Health Insurance Research Database to follow 2051 patients with schizophrenia from 1998 to 2013...
January 11, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28062214/in-utero-exposure-to-atypical-antipsychotic-drug-risperidone-effects-on-fetal-neurotoxicity-in-hippocampal-region-and-cognitive-impairment-in-rat-offspring
#3
K P Singh, Manoj Kr Singh
Clinical studies indicate that about one-third of pregnant women with psychotic symptoms are exposed to either typical or atypical antipsychotic drugs (APDs). Reports on prenatal subject/model are lacking hence, the present study was undertaken to investigate the effect of prenatal exposure to risperidone (RIS) on the fetal hippocampus, and their related functional changes in young rat offspring. In this study, pregnant Wistar rats were exposed to equivalent therapeutic doses of RIS at 0.8mg/kg, 1.0mg/kg, and 2...
January 4, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28049887/evaluation-of-the-expression-profile-of-extrapyramidal-symptoms-due-to-antipsychotics-by-data-mining-of-japanese-adverse-drug-event-report-jader-database
#4
Eiji Kose, Kana Uno, Hiroyuki Hayashi
 Typical antipsychotics are easily expressed as adverse events such as extrapyramidal symptom (EPS). On the other hand, incidence of adverse events due to atypical antipsychotics is low. Therefore, currently, atypical antipsychotics are widely used to treat schizophrenia. However, it has been reported that there is no difference in the frequency of EPS in atypical and typical antipsychotics. This study aimed to evaluate the expression profile of EPS in atypical and typical antipsychotics treatment using the Japanese Adverse Drug Event Report (JADER) database...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28045840/acute-dystonia-versus-neuroleptic-malignant-syndrome-without-fever-in-an-eight-year-old-child
#5
Rita Sridaran, Chadd E Nesbit
Neuroleptic malignant syndrome (NMS) is a rare but potentially fatal complication of the use of certain medications. It is being seen more often in the pediatric population because of the increasing use of both typical and atypical antipsychotics in children. Rapid recognition of NMS is important to emergency physicians because timely treatment can be life saving. Acute dystonia is also a well-known and more common adverse effect of certain types of antipsychotics, more commonly seen with the typical antipsychotics versus the atypical antipsychotics...
January 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28009769/movement-disorders-induced-by-the-atypical-antipsychotic-aripiprazole
#6
Karim Selfani, Valérie L Soland, Sylvain Chouinard, Philippe Huot
OBJECTIVES: Aripiprazole is an antipsychotic that acts as a partial agonist at dopamine D2 receptors. Because of its partial agonist activity, it was believed that aripiprazole would be less susceptible than typical antipsychotics to induce extrapyramidal side effects. However, a few case-reports and case-series detailing aripiprazole-induced movement disorders have been published, suggesting that aripiprazole-induced movement disorders may arise. Here, we seek to report further cases of aripiprazole-induced movement disorders to raise the awareness of clinicians on this adverse effect...
January 2017: Neurologist
https://www.readbyqxmd.com/read/28003229/case-of-coeliac-disease-presenting-in-the-psychiatry-ward
#7
Albino J Oliveira-Maia, Isabel Andrade, J Bernardo Barahona-Corrêa
We describe a case of coeliac disease that was diagnosed in the psychiatry inpatient unit of a general hospital. The patient was admitted due to suicidal behaviours and developed an agitated catatonic state while in the inpatient psychiatry unit. An extensive diagnostic study allowed for the diagnosis of coeliac disease and while her state was unresponsive to antidepressants, anxiolytics, antipsychotics and electroconvulsive therapy, the patient improved significantly when a gluten-free diet was started. While it is well known that, occasionally, gluten sensitivity and coeliac disease can present as brain gluten sensitivity, such cases are typically characterised by motor and/or cognitive symptoms and by white matter abnormalities...
December 21, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27971399/treatment-persistence-and-discontinuation-risk-of-typical-depot-and-atypical-long-acting-antipsychotics-in-patients-with-schizophrenia-in-poland
#8
N Wierzbicka, P Jakubczak, D Krupa, J Burski, I Skrzekowska-Baran, M Czech
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27951451/electroencephalographic-study-of-chlorpromazine-alone-or-combined-with-alpha-lipoic-acid-in-a-model-of-schizophrenia-induced-by-ketamine-in-rats
#9
Luis Rafael Leite Sampaio, Lucas Teixeira Nunes Borges, Talita Matias Barbosa, Natalia Castelo Branco Matos, Ricardo de Freitas Lima, Mariana Nascimento de Oliveira, Viviane Nóbrega Gularte, Manoel Cláudio Azevedo Patrocínio, Danielle Macêdo, Otoni Cardoso do Vale, Silvânia Maria Mendes de Vasconcelos
Schizophrenia is characterized by behavioral symptoms, brain function impairments and electroencephalographic (EEG) changes. Dysregulation of immune responses and oxidative imbalance underpins this mental disorder. The present study aimed to investigate the effects of the typical antipsychotic chlorpromazine (CP) alone or combined with the natural antioxidant alpha-lipoic acid (ALA) on changes in the hippocampal average spectral power induced by ketamine (KET). Three days after stereotactic implantation of electrodes, male Wistar rats were divided into groups treated for 10 days with saline (control) or KET (10 mg/kg, IP)...
December 3, 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27933713/antipsychotic-adjunctive-therapy-to-mood-stabilizers-and-1-year-rehospitalization-rates-in-bipolar-disorder-a-cohort-study
#10
Eldar Hochman, Amir Krivoy, Ayal Schaffer, Abraham Weizman, Avi Valevski
OBJECTIVES: Antipsychotic adjunctive therapy to mood stabilizers (MSs) may improve relapse prevention; however, only a few naturalistic studies, reflecting more generalizable bipolar disorder (BD) samples, support this notion. We compared the 1-year rehospitalization rates of manic patients with bipolar I disorder (BD-I) who were discharged with MS (lithium or valproate) monotherapy or with adjunctive atypical or typical antipsychotic therapy. METHODS: A total of 201 patients with BD-I who were hospitalized with manic episodes between 2005 and 2013 were retrospectively followed for 1-year rehospitalization rates according to treatment at discharge: MS monotherapy, MS with atypical antipsychotics, and MS with typical antipsychotics...
December 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27922607/endocytosis-following-dopamine-d2-receptor-activation-is-critical-for-neuronal-activity-and-dendritic-spine-formation-via-rabex-5-pdgfr%C3%AE-signaling-in-striatopallidal-medium-spiny-neurons
#11
N Shioda, Y Yabuki, Y Wang, M Uchigashima, T Hikida, T Sasaoka, H Mori, M Watanabe, M Sasahara, K Fukunaga
Aberrant dopamine D2 receptor (D2R) activity is associated with neuropsychiatric disorders, making those receptors targets for antipsychotic drugs. Here, we report that novel signaling through the intracellularly localized D2R long isoform (D2LR) elicits extracellular signal-regulated kinase (ERK) activation and dendritic spine formation through Rabex-5/platelet-derived growth factor receptor-β (PDGFRβ)-mediated endocytosis in mouse striatum. We found that D2LR directly binds to and activates Rabex-5, promoting early-endosome formation...
December 6, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27918972/atypical-antipsychotics-normalize-low-gamma-evoked-oscillations-in-patients-with-schizophrenia
#12
Manuel Alegre, Patricio Molero, Miguel Valencia, Guillermo Mayner, Felipe Ortuño, Julio Artieda
The symptoms of schizophrenia might be mediated by a cortical network disconnection which may disrupt the cortical oscillatory activity. Steady-state responses are an easy and consistent way to explore cortical oscillatory activity. A chirp-modulated tone (increasing the frequency of the modulation in a linear manner) allows a fast measure of the steady-state response to different modulation rates. With this approach, we studied the auditory steady-state responses in two groups of patients with schizophrenia (drug-naive and treated with atypical antipsychotic drugs), in order to assess the differences in their responses with respect to healthy subjects, and study any potential effect of medication...
January 2017: Psychiatry Research
https://www.readbyqxmd.com/read/27905940/drug-poisoning-deaths-in-the-united-states-1999-2012-a-statistical-adjustment-analysis
#13
Christopher J Ruhm
BACKGROUND: Drug poisoning mortality in the US has risen rapidly but the drugs involved are frequently unspecified on death certificates. METHODS: Reported and adjusted proportions of specific drug types involved in fatal drug poisonings were calculated using vital statistics mortality data from 1999 to 2012. The adjusted proportions were those predicted to occur if at least one specific type of drug had been identified on the death certificates of all poisoning fatalities...
January 15, 2016: Population Health Metrics
https://www.readbyqxmd.com/read/27889598/association-between-antipsychotic-drug-use-and-cataracts-in-patients-with-bipolar-disorder-a-population-based-nested-case-control-study
#14
Che-Sheng Chu, Po-Han Chou, Yi-Huei Chen, Min-Wei Huang, Min-Yen Hsu, Tsuo-Hung Lan, Ching-Heng Lin
BACKGROUND: No previous study has focused on the association between use of antipsychotic drugs and the development of cataracts in patients with bipolar disorder (BD); hence, we aimed to examine this association in the present study. METHODS: We conducted a retrospective nested case-control study using data from the National Health Insurance Database of Taiwan between 2000 and 2011. A total of 3292 BD patients, 1684 with cataracts and 1608 controls matched for age, sex, and index date, were included...
February 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27888683/lifetime-antipsychotic-medication-and-cognitive-performance-in-schizophrenia-at-age-43-years-in-a-general-population-birth-cohort
#15
Anja P Husa, Jani Moilanen, Graham K Murray, Riikka Marttila, Marianne Haapea, Irina Rannikko, Jennifer H Barnett, Peter B Jones, Matti Isohanni, Anne M Remes, Hannu Koponen, Jouko Miettunen, Erika Jääskeläinen
This naturalistic study analysed the association between cumulative lifetime antipsychotic dose and cognition in schizophrenia after an average of 16.5 years of illness. Sixty participants with schizophrenia and 191 controls from the Northern Finland Birth Cohort 1966 were assessed at age 43 years with a neurocognitive test battery. Cumulative lifetime antipsychotic dose-years were collected from medical records and interviews. The association between antipsychotic dose-years and a cognitive composite score based on principal component analysis was analysed using linear regression...
January 2017: Psychiatry Research
https://www.readbyqxmd.com/read/27855720/pharmacological-interventions-for-agitation-in-patients-with-traumatic-brain-injury-protocol-for-a-systematic-review-and-meta-analysis
#16
David R Williamson, Anne Julie Frenette, Lisa Burry, Marc M Perreault, Emmanuel Charbonney, François Lamontagne, Marie-Julie Potvin, Jean-François Giguère, Sangeeta Mehta, Francis Bernard
BACKGROUND: Traumatic brain injury (TBI) is a worldwide leading cause of mortality and disability. Among TBI complications, agitation is a frequent behavioural problem. Agitation causes potential harm to patients and caregivers, interferes with treatments, leads to unnecessary chemical and physical restraints, increases hospital length of stay, delays rehabilitation, and impedes functional independence. Pharmacological treatments are often considered for agitation management following TBI...
November 17, 2016: Systematic Reviews
https://www.readbyqxmd.com/read/27855434/trends-in-the-outpatient-utilization-of-antipsychotic-drugs-in-the-city-of-zagreb-in-the-ten-year-period-as-a-tool-to-assess-drug-prescribing-rationality
#17
Marina Polić-Vižintin, Ingrid Tripković, Danijela Štimac, Zvonimir Šostar, Mirjana Orban
BACKGROUND: The aim was to determine distribution and trends in the outpatient utilization of antipsychotics to evaluate the rationality of antipsychotic drug prescribing during the ten year period. SUBJECTS AND METHODS: The epidemiological method of descriptive and analytical observation was used. Data on drug utilization from Zagreb Municipal Pharmacy were used to calculate the number of defined daily doses (DDD) and DDD per 1000 inhabitants per day (DDD/TID) using the World Health Organization Anatomical-Therapeutic-Chemical methodology...
December 2016: Psychiatria Danubina
https://www.readbyqxmd.com/read/27823949/risk-of-breast-cancer-in-risperidone-users-a-nationwide-cohort-study
#18
Johan Reutfors, Louise Wingård, Lena Brandt, Yiting Wang, Hong Qiu, Helle Kieler, Shahram Bahmanyar
BACKGROUND: Several antipsychotics, especially risperidone, are known to increase serum prolactin. Hyperprolactinemia has been linked to the development of mammary gland tumors in animal studies. We therefore investigated the risk of breast cancer in a nationwide cohort of women using risperidone or other antipsychotics. METHODS: All women, 18years or older, who initiated treatment with risperidone or any other antipsychotic between 2006 and 2012 were identified in Swedish nationwide registers...
November 4, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27816557/influence-of-magnesium-supplementation-on-movement-side-effects-related-to-typical-antipsychotic-treatment-in-rats
#19
Maikel Kronbauer, Vinicia Garzela Metz, Karine Roversi, Veronica Tironi Dias, Caren Tatiane de David Antoniazzi, Raquel Cristine da Silva Barcelos, Marilise E Burger
Chronic use of typical antipsychotic haloperidolis related to movement disturbances such as parkinsonism, akathisia and tardive dyskinesia which have been related to excitotoxicity in extrapyramidal brain areas, requiring their prevention and treatment. In the current study we evaluated the influence of the magnesium on prevention (for 28days before-), reversion (for 12days after-) and concomitant supplementation on haloperidol-induced movement disorders in rats. Sub-chronic haloperidol was related to orofacial dyskinesia (OD) and catalepsy development, increased generation of reactive species (RS) and levels of protein carbonyl (PC) in cortex, striatum and substantia nigra (SN) in all experimental protocols...
November 2, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27793669/antipsychotics-promote-neural-differentiation-of-human-ips-cell-derived-neural-stem-cells
#20
Minoru Asada, Shuki Mizutani, Masatoshi Takagi, Hidenori Suzuki
We investigated the effects of antipsychotics on human induced pluripotent stem cell (hiPSC)-derived neural stem cell (NSC) differentiation. Induction of NSCs from hiPSCs was performed using PSC neural induction medium. Induced NSCs were subsequently cultured in neural differentiation medium containing antipsychotics. Cultured cells were subjected to neural differentiation marker analysis. As previously shown in rodent cells, antipsychotics promoted neural differentiation compared with vehicle treatment. Atypical antipsychotics appear to possess more differentiation induction potential than typical ones...
October 25, 2016: Biochemical and Biophysical Research Communications
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