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https://www.readbyqxmd.com/read/29475205/the-pituitary-thyroid-axis-and-prolactin-secretion-in-hemodialysis-patients-in-two-endemic-regions-of-eastern-germany
#1
Franz Maximilian Rasche, Ronny Rettig, Thomas Frese, Wilma Gertrud Rasche, Filip Barinka, Guenter Roesl, Frieder Keller, Tom H Lindner, Jochen G Schneider, Joachim Beige, Thomas Ebert, Stephan Schiekofer
INTRODUCTION: Endocrine disorders of the pituitary axes are frequent in patients with hemodialysis (CKD5D). The aim of this multicenter study (Leipzig (L), Quedlinburg and Blankenburg in the Harz region (Hz)) in CKD5D patients was to evaluate influences of CKD5D related factors, morphological and biochemical parameters, and serum iodine and prolactin concentrations on the pituitary-thyroid axis. PATIENTS AND METHODS: 170 patients (L n=58; Hz n=112) were included in this prospective, non-interventional, cross-sectional study...
February 23, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29475178/progranulin-facilitates-the-increase-of-platelet-count-in-immune-thrombocytopenia
#2
Yingyi Yu, Yuanyuan Shi, Xinyi Zuo, Qi Feng, Yu Hou, Wei Tang, Yi Lu, Fan Yi, Ming Hou, Yuan Yu, Jun Peng
INTRODUCTION: Progranulin (PGRN) is emerging as a critical immune mediator involved in a variety of autoimmune disorders. However, its role in immune thrombocytopenia (ITP) remains unclear. MATERIALS AND METHODS: In this study, the enzyme-linked immunosorbent assay was used for determining the plasma levels of PGRN in ITP patients vs. healthy controls. In addition, the role of PGRN in ITP was investigated in two kinds of ITP murine models. Further, we explored whether PGRN functioned by affecting the number of T regulatory cells (Tregs) using flow cytometry...
February 17, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29475168/spontaneous-mesenteric-hematoma-of-the-sigmoid-colon-associated-with-rivaroxaban-a-case-report
#3
Katsuhisa Hirano, Tadashi Bando, Soshi Osawa, Tetsuro Shimizu, Tomoyuki Okumura, Tsutomu Fujii
INTRODUCTION: Mesenteric hematoma is a rare condition caused by bleeding localized in the mesenteric vascular tree. This is a first report of spontaneous mesenteric hematoma caused by rivaroxaban. PRESENTATION OF CASE: The patient was a 71-year-old man who had taken rivaroxaban for paroxysmal atrial fibrillation. He had experienced abdominal pain and diarrhea for the prior 3 days. He had little melena and was referred to our institute. He presented with hypotension on arrival...
February 10, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29475100/new-thiazolidinedione-lpsf-gq-2-inhibits-nf%C3%AE%C2%BAb-and-mapk-activation-in-lps-induced-acute-lung-inflammation
#4
Laise Aline Martins Dos Santos, Gabriel Barros Rodrigues, Fernanda Virgínia Barreto Mota, Maria Eduarda Rocha de França, Karla Patrícia de Souza Barbosa, Wilma Helena de Oliveira, Sura Wanessa Santos Rocha, Deniele Bezerra Lós, Amanda Karolina Soares Silva, Teresinha Gonçalves da Silva, Christina Alves Peixoto
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are responsible for high mortality rates in critical patients. Despite >50 years of intensive research, there is no pharmacologically effective treatment to treat ALI. PPARs agonists, chemically named thiazolidinediones (TZDs) have emerged as potential drugs for the treatment of ALI and ARDS due to their anti-inflammatory efficacy. The present study aims to evaluate the potential anti-inflammatory effects of new TZDs derivatives, LPSF/GQ-2 and LPSF/RA-4, on ALI induced by LPS...
February 20, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29475096/phenotypic-and-functional-profile-of-th17-and-treg-cells-in-allergic-fungal-sinusitis
#5
Gargi Rai, Shukla Das, Mohammad Ahmad Ansari, Praveen Kumar Singh, Neelima Gupta, Sonal Sharma, Naseem Akhter, Vishnampettai G Ramachandran, Shafiul Haque, Sajad Ahmad Dar
Interleukin-17 producing T helper (Th17) and regulatory T cells (Treg) cells have been identified to play a critical role in atopic inflammation. However, conflicting reports on the role of Th17/Treg cells in allergic fungal rhinosinusitis (AFRS) patients of different ethnicities has mystified its pathogenesis. To better understand the pathophysiological mechanisms involved in AFRS, we conducted a prospective, analytical, case-control study involving 40 confirmed immunocompetent AFRS patients and 20 healthy controls...
February 20, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29475078/damage-of-the-temporal-lobe-and-apoe-status-determine-neural-compensation-in-mild-cognitive-impairment
#6
Laura Prieto Del Val, Jose L Cantero, Daniel Baena, Mercedes Atienza
In mild cognitive impairment (MCI), the APOE4 genotype is associated with accelerated memory decline, likely due to the impact of neuropathology on main cerebral networks required for successful memory retrieval and/or to decreased capacity for recruiting secondary networks that might compensate for that brain damage. Here, we tested this hypothesis in twenty-six healthy older adults and thirty-four MCI patients, of which sixteen were APOE4 carriers. Compared to controls, MCI showed hippocampal volume reduction, cortical thinning in frontal, temporal and parietal regions, and dysfunctional EEG oscillations across fronto-temporal networks...
February 2, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29474985/optimal-reference-gene-selection-for-expression-studies-in-human-reticulocytes
#7
Anu Aggarwal, Manu Jamwal, Ganesh Kumar V, Prashant Sharma, Man Updesh Singh Sachdeva, Deepak Bansal, Pankaj Malhotra, Reena Das
Reference genes are indispensable for normalizing mRNA levels across samples in real-time quantitative PCR. Their expression levels vary under different experimental conditions and due to several inherent characteristics. Appropriate reference gene selection is thus critical for gene-expression studies. This study aimed at selecting optimal reference genes for gene-expression analysis of reticulocytes and validating them in hereditary spherocytosis (HS) and β-thalassemia intermedia (βTI) patients. Seven reference genes (PGK1, MPP1, HPRT1, ACTB, GAPDH, RN18S1, and SDHA) were selected from published literature...
February 20, 2018: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/29474938/differential-family-experience-of-palliative-sedation-therapy-in-specialised-palliative-or-critical-care-units
#8
Hui-Shan Shen, Szu-Yin Chen, Denise Shuk Ting Cheung, Shu-Yi Wang, Lee Jung Jae, Chia-Chin Lin
CONTEXT: No study has examined the varying family experience of palliative sedation therapy (PST) for terminally ill patients in different settings. OBJECTIVES: To examine and compare family concerns about PST use and its effect on the grief suffered by terminally ill patients' families in palliative care units (PCU) or intensive care units (ICU). METHODS: A total of 154 family members of such patients were recruited in Taiwan, of whom 143 completed the study, with 81 from the PCU and 62 from the ICU...
February 20, 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29474842/inkt-cell-mediated-xcl1-xcr1-axis-promotes-allergic-airway-hyperresponsiveness-by-recruiting-cd103-dendritic-cells
#9
Yeon Duk Woo, Jaemoon Koh, Hye-Ryun Kang, Hye Young Kim, Doo Hyun Chung
BACKGROUND: The XCL1-XCR1 axis has been reported to play a role in immune homeostasis and inflammation. However, it is not known whether this axis has a critical function in allergic asthma. OBJECTIVE: In the present study, we explored that the iNKT cell-mediated XCL1-XCR1 axis regulated the allergic asthma. METHODS: Ovalbumin (OVA) or house dust mite (HDM)-induced asthma was developed in XCL1 or XCR1 knockout (KO) mice. RESULTS: XCL1 or XCR1 KO mice showed attenuation in airway hyperresponsiveness (AHR), numbers of CD103+ dendritic cells (DCs), and Th2 responses in the lungs compared with wild-type (WT) mice during OVA or HDM-induced asthma...
February 20, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29474802/exploring-perceptions-about-insulin-dependent-diabetes-mellitus-in-adolescent-patients-and-peers
#10
Katarzyna Marshall, Halley Martin, Kim Siarkowski Amer
Friends can provide encouragement and support during stressful times. Friends are even more important for children coping with chronic illness such as adolescents managing insulin dependent diabetes mellitus (IDDM). Nurses need to recognize that the knowledge and care of both the children coping with diabetes and friends can be critical. This study explored perceptions of adolescents managing diabetes and their peers. The non-affected peers and adolescents with IDDM ranged in age between 15-18 were studied using an exploratory qualitative method...
March 2018: Comprehensive Child and Adolescent Nursing
https://www.readbyqxmd.com/read/29474665/catastrophizing-interferes-with-cognitive-modulation-of-pain-in-women-with-fibromyalgia
#11
Laura D Ellingson, Aaron J Stegner, Isaac J Schwabacher, Jacob B Lindheimer, Dane B Cook
Background: Pain modulation is a critical function of the nociceptive system that includes the ability to engage descending pain control systems to maintain a functional balance between facilitation and inhibition of incoming sensory stimuli. Dysfunctional pain modulation is associated with increased risk for chronic pain and is characteristic of fibromyalgia (FM). Catastrophizing is also common in FM. However, its influence on pain modulation is poorly understood. Objective: To determine the role of catastrophizing on central nervous system processing during pain modulation in FM via examining brain responses and pain sensitivity during an attention-distraction paradigm...
February 21, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29474652/monitoring-quality-of-care-in-acute-myocardial-infarction-patients-using-retrospective-registry-data
#12
Giovanni Veronesi, Antonella Zambon, John F Beltrame, Francesco Gianfagna, Giovanni Corrao, Marco M Ferrario
Background: Hospital-based registries provide a key contribution in assessing the quality of care in acute myocardial infarction (MI) patients, although some concern on selection bias of included cases has recently arisen. We investigated the feasibility of a retrospective, population-based registry of MIs in monitoring the quality of care. Methods: We identified all the hospitalizations with a diagnosis of acute MI among 35-79 years old residents in the Varese province, Northern Italy, in 2007-2008...
February 21, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29474524/hematomas-in-aesthetic-surgery
#13
Keith Hood, Nishant Ganesh Kumar, K Kye Higdon
Hematomas represent one of the most common postoperative complications in patients undergoing aesthetic surgery. Depending on the type of procedure performed, hematoma incidence and presentation can vary greatly. Understanding the risk factors for hematoma formation and the preoperative considerations to mitigate the risk is critical to provide optimal care to the aesthetic patient. Various perioperative prevention measures may also be employed to minimize hematoma incidence. The surgeon's ability to adequately diagnose and treat hematomas after aesthetic surgery is not only crucial to patient care but also minimizes the risk of further complications or long-term sequelae...
February 21, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29474481/a-dual-boundary-classifier-for-predicting-acute-hypotensive-episodes-in-critical-care
#14
Sakyajit Bhattacharya, Vijay Huddar, Vaibhav Rajan, Chandan K Reddy
An Acute Hypotensive Episode (AHE) is the sudden onset of a sustained period of low blood pressure and is one among the most critical conditions in Intensive Care Units (ICU). Without timely medical care, it can lead to an irreversible organ damage and death. By identifying patients at risk for AHE early, adequate medical intervention can save lives and improve patient outcomes. In this paper, we design a novel dual-boundary classification based approach for identifying patients at risk for AHE. Our algorithm uses only simple summary statistics of past Blood Pressure measurements and can be used in an online environment facilitating real-time updates and prediction...
2018: PloS One
https://www.readbyqxmd.com/read/29474470/antibiotic-use-knowledge-and-health-literacy-among-the-general-population-in-berlin-germany-and-its-surrounding-rural-areas
#15
Florian Salm, Clemens Ernsting, Adelheid Kuhlmey, Melanie Kanzler, Petra Gastmeier, Paul Gellert
OBJECTIVES: Knowledge concerning antibiotic use in the general population is insufficient. The way health literacy is related to antibiotic use aside from knowledge needs further investigation. Our aim was to compare the levels of knowledge of antibiotics and health literacy in individuals who had taken antibiotics in recent years compared with those who not had taken antibiotics. METHODS: A population-based cross-sectional survey of 2,000 individuals aged 35 and older from Berlin, Germany and its surrounding rural and suburban areas (response rate 59%) with strata urban/rural, sex, age, and education...
2018: PloS One
https://www.readbyqxmd.com/read/29474336/endothelial-cell-specific-molecule-1-in-critically-ill-patients-with-hematologic-malignancy
#16
Lara Zafrani, Matthieu Resche-Rigon, Nathalie De Freitas Caires, Alexandre Gaudet, Daniel Mathieu, Erika Parmentier-Decrucq, Virginie Lemiale, Djamel Mokart, Frédéric Pène, Achille Kouatchet, Julien Mayaux, François Vincent, Martine N'yunga, Fabrice Bruneel, Antoine Rabbat, Christine Lebert, Pierre Perez, Anne-Pascale Meert, Dominique Benoit, Michael Darmon, Elie Azoulay
OBJECTIVES: To assess whether serum concentration of endothelial cell-specific molecule-1 (Endocan) at ICU admission is associated with the use of ICU resources and outcomes in critically ill hematology patients. DESIGN: Prospective multicenter cohort study. SETTING: Seventeen ICUs in France and Belgium. PATIENTS: Seven hundred forty-four consecutive critically ill hematology patients; 72 critically ill septic patients without hematologic malignancy; 276 healthy subjects...
March 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29474326/transport-time-and-preoperating-room-hemostatic-interventions-are-important-improving-outcomes-after-severe-truncal-injury
#17
John B Holcomb
OBJECTIVES: Experience in the ongoing wars in Iraq and Afghanistan confirm that faster transport combined with effective prehospital interventions improves the outcomes of patients suffering hemorrhagic shock. Outcomes of patients with hemorrhagic shock and extremity bleeding have improved with widespread use of tourniquets and early balanced transfusion therapy. Conversely, civilian patients suffering truncal bleeding and shock have the same mortality (46%) over the last 20 years. To understand how to decrease this substantial mortality, one must first critically evaluate all phases of care from point of injury to definitive hemorrhage control in the operating room...
March 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29474319/the-association-of-icu-acuity-with-outcomes-of-patients-at-low-risk-of-dying
#18
Kelly C Vranas, Jeffrey K Jopling, Jennifer Y Scott, Omar Badawi, Michael O Harhay, Christopher G Slatore, Meghan C Ramsey, Michael J Breslow, Arnold S Milstein, Meeta Prasad Kerlin
OBJECTIVE: Many ICU patients do not require critical care interventions. Whether aggressive care environments increase risks to low-acuity patients is unknown. We evaluated whether ICU acuity was associated with outcomes of low mortality-risk patients. We hypothesized that admission to high-acuity ICUs would be associated with worse outcomes. This hypothesis was based on two possibilities: 1) high-acuity ICUs may have a culture of aggressive therapy that could lead to potentially avoidable complications and 2) high-acuity ICUs may focus attention toward the many sicker patients and away from the fewer low-risk patients...
March 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29474237/trends-in-cervical-cancer-screening-in-california-s-family-planning-program
#19
Heike Thiel de Bocanegra, Sandy K Navarro, Narissa J Nonzee, Sitaram Vangala, Xinkai Zhou, Charlene Chang, Anna-Barbara Moscicki
OBJECTIVE: Guidelines recommend 3-year cervical cancer screening intervals to avoid unnecessary invasive procedures; however, regular testing remains critical. We evaluated trends in cervical cancer screening among low-income women receiving family planning-related services and their association with patient and provider characteristics. MATERIALS AND METHODS: Using claims and enrollment data from California's publicly funded family planning program, we identified 540,026 women with a clinician visit at 216 sites between 2011 and 2015...
February 23, 2018: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/29474195/management-of-antiretrovirals-in-critically-ill-patients-great-progress-but-potential-pitfalls
#20
Dante A Suffredini, Jomy M George, Henry Masur
No abstract text is available yet for this article.
February 22, 2018: Critical Care Medicine
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