Jiayi Li, Zheng Wang, Yuwei Zhang, Yixi Li, Longfei Feng, Jinglin Wang, Jiming Zhang, Zhijun Zhou, Yunhui Zhang, Xiuli Chang
Short-chain chlorinated paraffins (SCCPs), a class of persistent organic pollutants, have been found to cause diverse organ and systemic toxicity. However, little is known about their neurotoxic effects. In this study, we exposed BV2, a mouse microglia cell line, to environmentally relevant concentration of SCCPs (1 μg/L, 10 μg/L, 100 μg/L) for 24 h to investigate their impacts on the nervous system. Our observations revealed that SCCPs induced the activation of BV2 microglia, as indicated by altered morphology, stimulated cell proliferation, enhanced phagocytic and migratory capabilities...
February 29, 2024: Environmental Research