keyword
MENU ▼
Read by QxMD icon Read
search

CHO loading

keyword
https://www.readbyqxmd.com/read/29777241/acute-effect-of-equicaloric-meals-varying-in-glycemic-index-and-glycemic-load-on-arterial-stiffness-and-glycemia-in-healthy-adults-a-randomized-crossover-trial
#1
Andreea Zurbau, Alexandra L Jenkins, Elena Jovanovski, Fei Au-Yeung, Emma A Bateman, Christy Brissette, Thomas M S Wolever, Amir Hanna, Vladimir Vuksan
BACKGROUND/OBJECTIVES: Dietary carbohydrate quality and quantity fluctuate but it is unknown which attribute takes precedence in vascular health preservation. We investigated all four permutations of glycemic index (GI) and glycemic load (GL) on acute vascular and glycemic responses. SUBJECTS/METHODS: Twenty-one healthy adults were screened for this crossover trial. Seventeen (8 M:9 F; 26.7 ± 12.3 y; BMI 22.2 ± 2.8 kg/m2 ) entered randomization and completed the study, receiving four isocaloric meals, varying in GI and GL, in random order at least 3 days apart...
May 17, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29750881/pathophysiological-characteristics-of-non-alcoholic-steatohepatitis-like-changes-in-cholesterol-loaded-type-2-diabetic-rats
#2
Y Toriniwa, M Muramatsu, Y Ishii, E Riya, K Miyajima, S Ohshida, K Kitatani, S Takekoshi, T Matsui, S Kume, T Yamada, T Ohta
Spontaneously Diabetic Torii (SDT) fatty rats, a new obese diabetic model, reportedly presented with features of non-alcoholic steatohepatitis (NASH) after 32 weeks of age. We tried to accelerate the onset of NASH in SDT fatty rats using dietary cholesterol loading and noticed changes in the blood choline level which is expected to be a NASH biomarker. Body weight and biochemical parameters were measured from 8 to 24 weeks of age. At 16 or 24 weeks, pathophysiological analysis of the livers were performed, hepatic lipids, lipid peroxides, and the expression of mRNA related to triglyceride (TG) synthesis, inflammation, and fibrosis were evaluated...
May 10, 2018: Physiological Research
https://www.readbyqxmd.com/read/29748615/specific-targeting-of-point-mutations-in-egfr-l858r-positive-lung-cancer-by-crispr-cas9
#3
Alvin Ho-Kwan Cheung, Chit Chow, Jinglin Zhang, Yuhang Zhou, Tingting Huang, Kayla Ching-Kei Ng, Terry Cho-Tsun Or, Yoyo Yao Yao, Yujuan Dong, Jackie Mei-Wah Fung, Lei Xiong, Aden Ka-Yin Chan, Wai-Ming Raymond Lung, Wei Kang, Ka-Fai To
Cancer cells are defined genetically by the mutations they harbor, commonly single nucleotide substitutions. Therapeutic approaches which specifically target cancer cells by recognizing these defining genetic aberrations are expected to exhibit minimal side-effects. However, current protein-based targeted therapy is greatly limited by the range of genes that can be targeted, as well as by acquired resistance. We hypothesized that a therapeutic oligonucleotide-based strategy may address this need of specific cancer targeting...
May 10, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29730306/empty-turnip-yellow-mosaic-virus-capsids-as-delivery-vehicles-to-mammalian-cells
#4
Doyeong Kim, Younghee Lee, Theo W Dreher, Tae-Ju Cho
Turnip yellow mosaic virus (TYMV) was able to enter animal cells when the spherical plant virus was conjugated with Tat, a cell penetrating peptide (CPP). Tat was chemically attached to the surface lysine residues of TYMV using hydrazone chemistry. Baby hamster kidney (BHK) cells were incubated with either unmodified or Tat-conjugated TYMV and examined by flow cytometry and confocal microscopic analyses. Tat conjugation was shown to be more efficient than Lipofectamine in allowing TYMV to enter the mammalian cells...
May 3, 2018: Virus Research
https://www.readbyqxmd.com/read/29729351/single-step-double-walled-nanoencapsulation-ssdn
#5
Aharon Azagury, Vera C Fonseca, Daniel Y Cho, James Perez-Rogers, Christopher M Baker, Elaine Steranka, Victoria Goldenshtein, Dominick Calvao, Eric M Darling, Edith Mathiowitz
A quick fabrication method for making double-walled (DW) polymeric nanospheres is presented. The process uses sequential precipitation of two polymers. By choosing an appropriate solvent and non-solvent polymer pair, and engineering two sequential phase inversions which induces first precipitation of the core polymer followed by precipitation of the shell polymer, DW nanospheres can be created instantaneously. A series of DW formulations were prepared with various core and shell polymers, then characterized using laser diffraction particle sizing, scanning electron microscopy, atomic force microscopy, Fourier transform infrared spectroscopy, and differential scanning calorimetry (DSC)...
May 2, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29720517/antiviral-activity-of-hiv-gp120-targeting-bispecific-t-cell-engager-bite%C3%A2-antibody-constructs
#6
Johannes Brozy, Erika Schlaepfer, Christina K S Mueller, Mary-Aude Rochat, Silvana K Rampini, Renier Myburgh, Tobias Raum, Peter Kufer, Patrick A Baeuerle, Markus Muenz, Roberto F Speck
Today's gold standard in HIV therapy is the combined antiretroviral therapy (cART). It requires strict adherence by patients and life-long medication, which can lower the viral load below detection limits and prevent HIV-associated immunodeficiency, but cannot cure patients. The bispecific T cell engaging (BiTE®) antibody technology has demonstrated long-term relapse-free outcomes in patients with relapsed and refractory acute lymphocytic leukemia. We here generated BiTE® antibody constructs that target the HIV-1 envelope protein gp120 (HIV gp120) using either the scFv B12 or VRC01, the first two extracellular domains (1+2) of human CD4 alone or joined to the single chain variable fragment (scFv) of the antibody 17b fused to an anti-human CD3ϵ scFv...
May 2, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29719912/vascularized-bone-grafting-for-reconstruction-of-oncologic-defects-in-the-spine-a-systematic-review-and-pooled-analysis-of-the-literature
#7
Rachel Pedreira, Charalampos Siotos, Brian H Cho, Stella M Seal, Deepa Bhat, Hannah M Carl, Michelle Seu, J P Wolinksy, Justin M Sacks
BACKGROUND:  Resection of primary spinal tumors requires reconstruction for restoration of spinal column stability. Traditionally, some combination of bone grafting and instrumentation is implemented. However, delayed healing environments are associated with pseudoarthrodesis and failure. Implementation of vascularized bone grafting (VBG) to complement hardware may present a solution. We evaluated the use of VBG in oncologic spinal reconstruction via systematic review and pooled analysis of literature...
May 2, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29713438/clinical-outcome-of-immediately-and-early-loaded-implants-with-laser-treated-surface-a-3-year-retrospective-study
#8
Richard Leesungbok, Jin-Ho Seo, Sung-Am Cho
PURPOSE: The marginal bone loss of implants with laser treated surface was investigated after six weeks of loading after implant installation to the mandible molar area. MATERIALS AND METHODS: A total of 23 implants were placed in the edentulous molar area of the mandible: 13 implants were immediately loaded and 10 implants were early loaded. The implants used were made of titanium grade 23, screw shaped, 4.2 mm in diameter, and 10 mm in length. Patients were evaluated with resonance frequency analysis at implant fixture installation and 1, 2 (final prosthesis installation), 3, 5, 8, and 14 months later...
April 2018: Journal of Advanced Prosthodontics
https://www.readbyqxmd.com/read/29700313/extraction-of-cage-like-sporopollenin-exine-capsules-from-dandelion-pollen-grains
#9
Tengfei Fan, Jae Hyeon Park, Quynh Anh Pham, Ee-Lin Tan, Raghavendra C Mundargi, Michael G Potroz, Haram Jung, Nam-Joon Cho
Pollen-based microcapsules such as hollow sporopollenin exine capsules (SECs) have emerged as excellent drug delivery and microencapsulation vehicles. To date, SECs have been extracted primarily from a wide range of natural pollen species possessing largely spherical geometries and uniform surface features. Nonetheless, exploring pollen species with more diverse architectural features could lead to new application possibilities. One promising class of candidates is dandelion pollen grains, which possess architecturally intricate, cage-like microstructures composed of robust sporopollenin biopolymers...
April 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29697206/subtyping-of-magnetically-isolated-breast-cancer-cells-using-magnetic-force-microscopy
#10
Kyeong-Jun Kim, Hyeon-Yeol Cho, Won-Jun Lee, Jeong-Woo Choi
Circulating tumor cell (CTC) which recently arisen as potential sources for monitoring and characterizing non-haematologic cancers and their metastatic derivatives. Immunomagnetic microbeads and magnetic nanoparticles (MNPs) have been extensively explored to isolate CTCs from blood samples. However, MNPs attached on the membrane protein are interrupted further analysis to distinguish the cancer subtype by consumption or blocking the target surface marker. Here, we describe an MNP-mediated analysis method for surface marker expression profile by magnetic force microscopy (MFM)...
April 26, 2018: Biotechnology Journal
https://www.readbyqxmd.com/read/29684695/effective-seeding-strategy-using-flat-type-poly-vinyl-alcohol-cryogel-for-anammox-enrichment
#11
Minkyu Choi, Kyungjin Cho, Seockheon Lee, Yun-Chul Chung, Joonhong Park, Hyokwan Bae
In this study, anammox enrichment reactors were operated using flat type poly (vinyl alcohol) cryogel (cryoPVAG) with precultured anammox bacteria (PAB) and activated sludge (AS) from an anoxic tack of the A2O process to evaluate the effect of different seeding sources on anammox enrichment. In addition, cryoPVAGs with different thicknesses (1, 2, and 3 mm) were used to investigate the effects of the thickness on anammox enrichment. The regression analysis with a modified Gompertz model showed that the start-up period of the anammox enrichment using PAB inoculum was approximately 14 days earlier than that of AS inoculum at a nitrogen loading rate of approximately 1 kg-N m-3 day-1 ...
April 13, 2018: Chemosphere
https://www.readbyqxmd.com/read/29678572/sildenafil-protects-neuronal-cells-from-mitochondrial-toxicity-induced-by-%C3%AE-amyloid-peptide-via-atp-sensitive-k-channels
#12
Yonghae Son, Koanhoi Kim, Hyok-Rae Cho
To understand the molecular mechanisms underlying the beneficial effects of sildenafil in animal models of neurological disorders, we investigated the effects of sildenafil on the mitochondrial toxicity induced by β-amyloid (Aβ) peptide. Treatment of HT-22 hippocampal neuronal cells with Aβ25∼35 results in increased mitochondrial Ca2+ load, which is subsequently suppressed by sildenafil as well as by diazoxide, a selective opener of the ATP-sensitive K+ channels (KATP ). However, the suppressive effects of sildenafil and diazoxide are significantly attenuated by 5-hydroxydecanoic acid (5-HD), a KATP inhibitor...
April 17, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29669200/a-novel-as1411-aptamer-based-three-way-junction-pocket-dna-nanostructure-loaded-with-doxorubicin-for-targeting-cancer-cells-in-vitro-and-in-vivo
#13
Seyed Mohammad Taghdisi, Noor Mohammad Danesh, Mohammad Ramezani, Rezvan Yazdian-Robati, Khalil Abnous
Active targeting of nanostructures containing chemotherapeutic agents can improve cancer treatment. Here, a three-way junction pocket DNA nanostructure was developed for efficient doxorubicin (Dox) delivery into cancer cells. Three-way junction pocket DNA nanostructure is composed of three strands of AS1411 aptamer as both therapeutic aptamer and nucleolin targeting, the potential biomarker of prostate (PC-3 cells) and breast (4T1 cells) cancers. The properties of the Dox-loaded three-way junction pocket DNA nanostructure was characterized and verified to have several advantages, including high serum stability and pH-responsive property...
April 18, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29663698/comparative-study-of-two-droplet-based-dissolving-microneedle-fabrication-methods-for-skin-vaccination
#14
Chisong Lee, Hongil Kim, Suyong Kim, Shayan F Lahiji, Na-Young Ha, Huisuk Yang, Geonwoo Kang, Hai Yen Thi Nguyen, Yuri Kim, Myung-Sik Choi, Nam-Hyuk Cho, Hyungil Jung
Dissolving microneedles (DMNs) have been widely studied in medical applications due to their pain-free administration, superior efficiency, and safe drug delivery. In skin vaccination, preserving the activity of the encapsulated antigen is an important consideration, as antigen activity is lost during DMN fabrication because of various stress factors. These stress factors vary between fabrication methods and each method affects the antigen's activity to different degrees. In this study, the activity of encapsulated antigens delivered by DMNs is compared between two recently developed DMN fabrication methods; droplet-born air blowing (DAB) and centrifugal lithography (CL) for a model scrub typhus vaccine antigen, ScaA...
April 16, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29651373/using-modis-cloud-regimes-to-sort-diagnostic-signals-of-aerosol-cloud-precipitation-interactions
#15
Lazaros Oreopoulos, Nayeong Cho, Dongmin Lee
Coincident multi-year measurements of aerosol, cloud, precipitation and radiation at near-global scales are analyzed to diagnose their apparent relationships as suggestive of interactions previously proposed based on theoretical, observational, and model constructs. Specifically, we examine whether differences in aerosol loading in separate observations go along with consistently different precipitation, cloud properties, and cloud radiative effects. Our analysis uses a cloud regime (CR) framework to dissect and sort the results...
May 27, 2017: Journal of Geophysical Research. Atmospheres: JGR
https://www.readbyqxmd.com/read/29625371/purification-of-human-erythropoietin-by-affinity-chromatography-using-cyclic-peptide-ligands
#16
William S Kish, Matthew K Roach, Hiroyuki Sachi, Amith D Naik, Stefano Menegatti, Ruben G Carbonell
Prior work described the identification and characterization of erythropoietin-binding cyclic peptides SLFFLH, VVFFVH, FSLLHH and FSLLSH (all of the form cyclo[(Nα -Ac)Dap(A)-X1 -X6 -AE], wherein X1 -X6 is the listed sequences). In this work, the peptide ligands were synthesized on Toyopearl chromatographic resins and utilized for purifying recombinant human erythropoietin (rHuEPO) from complex sources. Elution buffer pH and composition were optimized to maximize the recovery of standard rHuEPO from the peptide resins...
March 27, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29599874/validation-and-reliability-of-the-korean-version-of-the-sport-anxiety-scale-2
#17
Seongkwan Cho, Hunhyuk Choi, Robert C Eklund, Insu Paek
The main purpose of the present study was to examine the validation and reliability of the Korean version of the Sport Anxiety Scale (SAS-2Kr) by evaluating its factorial invariance across gender. A total of 303 Korean collegiate athletes (198 males and 105 females) from 9 sports participated in the study, and they completed the demographic questionnaire and the SAS-2Kr containing 15 items to measure multidimensional trait anxiety and individual differences in the cognitive and somatic anxiety experienced by athletes...
March 2018: Journal of Human Kinetics
https://www.readbyqxmd.com/read/29579690/a-novel-approach-to-developing-a-reusable-marine-macro-algae-adsorbent-with-chitosan-and-ferric-oxide-for-simultaneous-efficient-heavy-metal-removal-and-easy-magnetic-separation
#18
Eun-Bi Son, Kyung-Min Poo, Hend Omar Mohamed, Yun-Jeong Choi, Wan-Cheol Cho, Kyu-Jung Chae
Chitosan modified magnetic kelp biochar (Chi-KBm ) was successfully synthesized for efficient removal of heavy metals (Cu2+ ) from wastewater. Interestingly, the characterization results indicated that Chi-KBm showed 6 times higher surface area (6.17 m2 /g) than the pristine magnetic kelp biochar KBm (0.97 m2 /g). In addition, new functional groups, such as NH and CN group, have been created on the surface of biochar as a result of chitosan modification process, which in turns led to improve the Cu2+ adsorption capacity...
March 17, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29570269/shear-adhesion-of-tapered-nanopillar-arrays
#19
Younghyun Cho, Helen K Minsky, Yijie Jiang, Kaiyang Yin, Kevin T Turner, Shu Yang
Tapered nanopillars with various cross sections, including cone-shaped, stepwise, and pencil-like structures (300 nm in diameter at the base of the pillars and 1.1 μm in height), are prepared from epoxy resin templated by nanoporous anodic aluminum oxide (AAO) membranes. The effect of pillar geometry on the shear adhesion behavior of these nanopillar arrays is investigated via sliding experiments in a nanoindentation system. In a previous study of arrays with the same geometry, it was shown that cone-shaped nanopillars exhibit the highest adhesion under normal loading while stepwise and pencil-like nanopillars exhibit lower normal adhesion strength due to significant deformation of the pillars that occurs with increasing indentation depth...
March 23, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29550143/surface-modification-of-paclitaxel-loaded-liposomes-using-d-%C3%AE-tocopheryl-polyethylene-glycol-1000-succinate-enhanced-cellular-uptake-and-cytotoxicity-in-multidrug-resistant-breast-cancer-cells
#20
Su-Min Han, Jong-Suep Baek, Min-Soo Kim, Sung-Joo Hwang, Cheong-Weon Cho
Liposomes can achieve a controlled release and an improved bioavailability of water- insoluble drug with minimized side effects. Paclitaxel is an efficient anticancer drug for the treatment of various cancers. However, paclitaxel has a solubility of 0.5 mg/L in water and a low bioavailability of 6.5%. Moreover, paclitaxel is a substrate for p-glycoprotein, which shows a decreased accumulation of drug within the cancer cell expressed by a p-glycoprotein. Therefore, the purpose of this study is to prepare a paclitaxel-loaded liposome and evaluate the effect of d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) as an inhibitor of p-glycoprotein on the paclitaxel-loaded liposome...
March 14, 2018: Chemistry and Physics of Lipids
keyword
keyword
97689
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"