Read by QxMD icon Read

CHO loading

Su-Min Han, Jong-Suep Baek, Min-Soo Kim, Sung-Joo Hwang, Cheong-Weon Cho
Liposomes can achieve a controlled release and an improved bioavailability of water- insoluble drug with minimized side effects. Paclitaxel is an efficient anticancer drug for the treatment of various cancers. However, paclitaxel has a solubility of 0.5 mg/L in water and a low bioavailability of 6.5%. Moreover, paclitaxel is a substrate for p-glycoprotein, which shows a decreased accumulation of drug within the cancer cell expressed by a p-glycoprotein. Therefore, the purpose of this study is to prepare a paclitaxel-loaded liposome and evaluate the effect of d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) as an inhibitor of p-glycoprotein on the paclitaxel-loaded liposome...
March 14, 2018: Chemistry and Physics of Lipids
Daejong Yang, Jaehwan Lee, Donghwan Kim, Incheol Cho, Jong G Ok, Inkyu Park
We propose ZnO nanowire and TiO2 nanotube based light sensors on flexible polymer substrates fabricated by localized hydrothermal synthesis and liquid phase deposition (LPD). This method realized simple and cost-effective in-situ synthesis and integration of ZnO and TiO2 one dimensional nanomaterials. The fabricated sensor devices with ZnO nanowires and TiO2 nanotubes show very high sensitivity and quick response to the ultraviolet (UV) and ambient light, respectively. In addition, our direct synthesis and integration method made mechanical robustness under external loading such as static and cyclic bending because of both the strong bonding between nanomaterial and electrode...
March 14, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Jong-Suep Baek, Young-Guk Na, Cheong-Weon Cho
While wogonin has been known to have cytotoxicity against various cancer cells, its bioavailability and cytotoxicity are low due to its low water solubility. Therefore, wogonin-loaded solid lipid nanoparticles were fabricated using a hot-melted evaporation technique. The highest solubility of wogonin was observed in stearic acid. Hence, wogonin-loaded solid lipid nanoparticles were composed of stearic acid as the lipid matrix. The physicochemical properties of the wogonin-loaded solid lipid nanoparticles were evaluated by dynamic laser scattering and scanning electron microscopy...
March 13, 2018: Nanomaterials
Matic Grom, Mirijam Kozorog, Simon Caserman, Andrej Pohar, Blaž Likozar
Protein A-based affinity chromatography is a highly-efficient separation method to capture, purify and isolate biosimilar monoclonal antibodies (mAb) - an important medical product of biopharmaceutical industrial manufacturing. It is considered the most expensive step in purification downstream operations; therefore, its performance optimization offers a great cost saving in the overall production expenditure. The biochemical mixture-separating specific interaction experiments with Chinese hamster ovary (CHO) cell culture harvest, containing glycosylated extracellular immunoglobulins (Ig), were made using five different state-of-the-art commercial resins...
March 1, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Song Yi Lee, Hyun-Jong Cho
Nanoassembly (NA) based on a D-α-tocopherol succinate (αTS) conjugated lysozyme (Lys) (Lys-αTS) was fabricated for tumor-selective delivery of curcumin (CUR) for breast cancer therapy. Lys and αTS were used as a biocompatible enzyme and a hydrophobic residue, respectively, for the preparation of nanocarriers in this study. Compared with CUR-loaded cross-linked Lys (c-Lys/CUR) NA, Lys-αTS/CUR NA exhibited a smaller hydrodynamic size (213 nm mean diameter), a narrower size distribution, and a more spherical shape...
November 2018: Drug Delivery
Kyung-Soon Park, Abdel Ghani Ibrahim Al Awamleh, Sung-Am Cho
PURPOSE: The purpose of this study was to analyze the effects of two different implant surface treatments on initial bone connection by comparing the Removal Torque Values (RTQs) at 7 and 10 days after chemically modified, sandblasted, large-grit and acid-etched (modSLA), and Laser-etched (LE) Ti implant placements. MATERIALS AND METHODS: Twenty modSLA and 20 LE implants were installed on the left and right tibias of 20 adult rabbits. RTQs were measured after 7 and 10 days in 10 rabbits each...
February 2018: Journal of Advanced Prosthodontics
Hyeon-Yeol Cho, Taek Lee, Jinho Yoon, Zhenlin Han, Hudifah Rabie, Ki Bum Lee, Wei Wen Su, Jeong-Woo Choi
In the present study, we fabricated magnetic oleosomes functionalized with recombinant proteins as a new carrier for oil-based lipophilic drugs for cancer treatment. The bioengineered oleosome is composed of neutral lipids surrounded by a phospholipid monolayer with embedded oleosin fusion proteins. The oleosin was genetically fused to a nanobody of a green fluorescent protein (GFP). A recombinant protein consisting of immunoglobulin-binding protein LG fused to GFP was used to couple the oleosome to an antibody for targeted delivery to breast cancer cells...
February 28, 2018: ACS Applied Materials & Interfaces
Nhiem Tran, Marion Hocquet, Blandine Eon, Parveen Sangwan, Julian Ratcliffe, Tracey M Hinton, Jacinta White, Berkay Ozcelik, Nicholas P Reynolds, Benjamin W Muir
The fight against infection in an era of emerging antibiotic resistant bacteria is one of the grandest scientific challenges facing society today. Nano-carriers show great promise in improving the antibacterial activity of antibiotics as they are able to enhance their solubility, provide sustained release and reduce toxic side effects via specifically targeting infection sites. Here, we investigate the antibacterial effect of two lipidic nano-carriers that contain the poorly soluble antibiotic rifampicin in their bilayers...
February 16, 2018: Journal of Colloid and Interface Science
Sei-Young Choi, Bongrae Cho
A new visible-light-induced photocatalyst based on several transition metals (iron, magnesium and manganese)-loaded TiO2 was evaluated for its anti-viral activity with influenza virus H1N1. Under a fluorescent lamp of 1000 lx, λ > 410 nm, the virus was eradicated to more than 99% within 30 min. Since this photocatalyst can be used for coating plastics, wall papers and walls, it would be desirable to use this photocatalyst to reduce viral transmission via droplets and aerosols as well as surface contact for disinfection...
February 21, 2018: Virus Research
Minkyu Choi, Kyungjin Cho, Dawoon Jeong, Yun-Chul Chung, Joonhong Park, Seockheon Lee, Hyokwan Bae
In this study, the effects of the ammonium loading rate (ALR) and inorganic carbon loading rate (ILR) on the nitrification performance and composition of a nitrifying bacterial community were investigated in a moving bed biofilm reactor, using poly(vinyl alcohol) (PVA) sponge cubes as a supporting carrier. Between the two ALRs of 0.36 and 2.16 kg-N m-1 d-1 , stable partial nitritation was achieved at the higher ALR. Inorganic carbon was dosed at high levels: 33.1, 22.0, 16.4, 11.0, and 5.4 times the theoretical amount...
February 22, 2018: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
Md Rokon Ud Dowla Biswas, Asghar Ali, Kwang Youn Cho, Won-Chun Oh
In the present work, we report the development of a WSe2-Graphene-TiO2 ternary nanocomposite via ultrasonic techniques and characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), and Raman spectroscopy. The band-gap of the WSe2-Graphene-TiO2 was estimated to be about 1.62 eV which is suitable for photodegradation process under under ultraviolet UV/Visible light irradiation. The photocatalytic potential of nanocomposites is investigated for CO2 reduction to CH3OH...
April 2018: Ultrasonics Sonochemistry
Colin Campbell, Yong Min Lee, Kuk Young Cho, Young-Gi Lee, Byeongdu Lee, Charudatta Phatak, Seungbum Hong
One of the challenges in developing Lithium anodes for Lithium ion batteries (LIB) is controlling the formation of Li dendrites during cycling of the battery. Nanostructuring and nanopatterning of electrodes shows a promising way to suppress the growth of Li dendrites. However, in order to control this behavior, a fundamental understanding of the effect of nanopatterning on the electro-mechanical properties of Li metal is necessary. In this paper, we have investigated the mechanical and wear properties of Li metal using Atomic Force Microscopy (AFM) in an airtight cell...
February 6, 2018: Scientific Reports
Seong-Ryeol Kim, Jae-Hyoung Song, Jae-Hee Ahn, Geun-Shik Lee, Huijeong Ahn, Sung-Il Yoon, Seung Goo Kang, Pyeung-Hyeun Kim, Sang-Min Jeon, Eun-Ji Choi, Sooyoung Shin, Younggil Cha, Sungchan Cho, Dong-Eun Kim, Sun-Young Chang, Hyun-Jeong Ko
Human rhinovirus (HRV) infection causes more than 80% of all common colds and is associated with severe complications in patients with asthma and chronic obstructive pulmonary disease. To identify antiviral drug against HRV infection, we screened 800 FDA-approved drugs and found budesonide as one of the possible drug candidates. Budesonide is a corticosteroid, which is commonly used to prevent exacerbation of asthma and symptoms of common cold. Budesonide specifically protects host cells from cytotoxicity following HRV infection, which depend on the expression of glucocorticoid receptor...
February 1, 2018: Antiviral Research
Hyeyoon Chang, Jin Hwa Hong, Jae Kwan Lee, Hyun Woong Cho, Yung Taek Ouh, Kyung Jin Min, Kyeong A So
OBJECTIVE: Impaired local cellular immunity contributes to persistent human papillomavirus (HPV) infection and development of cervical intraepithelial neoplasia (CIN). Programmed death-1 (PD-1) and its ligands PD-ligand-1 (L1) and PD-L2 are negative regulators of T cell activity in various cancers, but few studies exist. The aim of this study was to determine the clinicopathologic and immunologic parameters (PD-1, PD-L1, and PD-L2) related to the persistence/recurrence of CIN after conization...
January 29, 2018: Journal of Gynecologic Oncology
Chi Young Shim, Darae Kim, Sungha Park, Chan Joo Lee, Hyung-Ju Cho, Jong-Won Ha, Yang-Je Cho, Geu-Ru Hong
Continuous positive airway pressure (CPAP) therapy may decrease left ventricular (LV) loads and improve myocardial oxygenation. In this study, we investigated the effect of CPAP on LV diastolic function compared with sham treatment in patients with severe obstructive sleep apnoea (OSA).This 3-month prospective single-centre randomised sham-controlled trial analysed 52 patients with severe OSA. Patients were randomly assigned (1:1) to receive either CPAP or sham treatment for 3 months. The main investigator and patients were masked to the trial randomisation...
February 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Lian-Hua Cui, Chang-Guo Yan, Hui-Shan Li, Whee-Soo Kim, Liang Hong, Sang-Kee Kang, Yun-Jaie Choi, Chong-Su Cho
Synbiotics are a combination of probiotics and prebiotics, which lead to synergistic benefits in host welfare. Probiotics have been used as an alternative to antibiotics. Among the probiotics, Pediococcus acidilactici (PA) has shown excellent antimicrobial activity against Salmonella Gallinarum (SG) as a major poultry pathogen and has improved the production performances of animals. Inulin is widely used as a prebiotic for the improvement of animal health and growth. The main aim of this study is to investigate the effect of the antimicrobial activity of inulin nanoparticles (INs)-internalized PA encapsulated into alginate/chitosan/alginate (ACA) microcapsules (MCs) in future in vivo application...
February 1, 2018: Journal of Microbiology and Biotechnology
Yoon Je Cho, Dhrumil Patel, Young Soo Chun, Won Ju Shin, Kee Hyung Rhyu
BACKGROUND: The aim of this study is to present a treatment for end-stage pyogenic arthritis of the hip using a novel cement spacer. This spacer caused less damage to the proximal femoral bone and made the conversion to total hip arthroplasty (THA) more convenient while maintaining the advantages of current cement spacers loaded with antibiotics. METHODS: We retrospectively reviewed 10 consecutive cases of hip pyogenic arthritis with joint destruction. These cases occurred from September 2009 to June 2015...
December 29, 2017: Journal of Arthroplasty
Gantumur Battogtokh, Oyuntuya Gotov, Jee He Kang, Jinsung Cho, Tae Ho Jeong, Ganzorig Chimed, Young Tag Ko
AIM: The objective of this study was to develop a mitochondria-targeted anticancer drug, docetaxel (DTX), for chemotherapy. MATERIALS & METHODS: The DTX was conjugated to 4-carboxybutyl triphenylphosphonium (TPP) to enhance mitochondrial targeting, and the TPP-DTX conjugate was further loaded into folate-cholesteryl albumin (FA-chol-BSA) nanoparticles (NPs) to improve its biocompatibility. RESULTS & CONCLUSION: In vitro studies showed that TPP-DTX and its NP primarily accumulated in the mitochondria; generated high reactive oxygen species, leading to mitochondrial disruption and cell apoptosis; and had a higher cytotoxicity against cancer cells...
January 17, 2018: Nanomedicine
Do-Yeon Cho, Dong-Jin Lim, Calvin Mackey, Daniel Skinner, Christopher Weeks, Gobind S Gill, Robert W Hergenrother, William E Swords, Bradford A Woodworth
BACKGROUND: The ciprofloxacin-coated sinus stent (CSS) has unique therapeutic potential to deliver antibiotics to the sinuses. The objective of this study is to evaluate the efficacy of the CSS stent in eliminating Pseudomonas aeruginosa infection in a rabbit model of sinusitis. METHODS: A ciprofloxacin-eluting sinus stent was created by coating ciprofloxacin/Eudragit RS100 on biodegradable poly-D/L-lactic acid (2 mg). After analyzing in-vitro inhibition of P aeruginosa (PAO-1 strain) biofilm formation, a total of 8 stents (4 shams, 4 CSSs) were placed unilaterally in rabbit maxillary sinuses via dorsal sinusotomy after inducing infection for 1 week with PAO-1...
January 15, 2018: International Forum of Allergy & Rhinology
Byung In Lee, Soon Kee No, Sang-Doe Yi, Hyang Woon Lee, Ok Joon Kim, Sang Ho Kim, Myeong Kyu Kim, Sung Eun Kim, Yo Sik Kim, Jae Moon Kim, Se-Jin Lee, Dong Jin Shin, Sung Pa Park, Yeong In Kim, Kyoung Heo, Yong Won Cho, Yang-Je Cho, Youn Nam Kim
PURPOSE: To compare controlled-release carbamazepine monotherapy (CBZ-CR) with lamotrigine and valproate combination therapy (LTG + VPA) in equivalent total drug load, as initial drug regimen in untreated patients with partial and/or generalized tonic-clonic seizures (GTCS). METHODS: This unblinded, randomized, 60-week superiority trial recruited patients having two or more unprovoked seizures with at least one seizure during previous three months. After randomization into CBZ-CR or LTG + VPA, patients entered into eight-week titration phase (TP), followed by 52-week maintenance phase (MP)...
December 29, 2017: Seizure: the Journal of the British Epilepsy Association
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"