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Tahir Maqbool, Jinwoo Cho, Jin Hur
Excitation emission matrix-parallel factor analysis (EEM-PARAFAC) and size exclusion chromatography (SEC) were utilized to explore the dynamics in extracellular polymeric substances (EPS), soluble microbial products (SMP), and effluent for the membrane bioreactors at two different organic loading rates (OLRs). Combination of three different fluorescent components explained the compositional changes of dissolved organic matter. The lower OLR resulted in a higher production of tryptophan-like component (C1) in EPS, while the opposite trends were found for the other two components (humic-like C2 and tyrosine-like C3), signifying the role of C1 in the endogenous condition...
March 9, 2017: Bioresource Technology
Geun Joo Choi, Hyun Kang, Min Eui Hong, Hwa Yong Shin, Chong Wha Baek, Yong Hun Jung, Younsuk Lee, Jeong Wook Kim, I L Kyu Park, Wan Jin Cho
BACKGROUND: Pain and adhesion are problematic issues after surgery. Lidocaine has analgesics and anti-inflammatory properties, and poloxamer/alginate/CaCl2 (PACM) is a known antiadhesive agent. We hypothesized that the novel combination of lidocaine as chemical barrier and PACM as physical barrier would be beneficial for both postoperative pain and adhesion. The purpose of this study was to investigate the effects of lidocaine-loaded PACM in a rat model of incisional pain. Primary outcome was to evaluate between-group differences for the mechanical withdrawal threshold (MWT) measured by von Frey filament in various concentrations of lidocaine-loaded PACM applied, PACM applied, and sham-operated groups...
March 17, 2017: Anesthesia and Analgesia
Hee J Park, Hyuck J Jung, Myoung J Ho, Dae R Lee, Ha R Cho, Yong S Choi, Joonho Jun, Miwon Son, Myung J Kang
A doubly enteric-coated multiple-unit tablet (DET) of bisacodyl (BD) was formulated to selectively deliver the stimulant laxative to the large intestine. Solubilized BD in surfactants was adsorbed into the porous carrier and primarily coated with different combinations of pH-sensitive polymers (Eudragit S and Eudragit L) and time-dependent release polymer (Eudragit RS). BD-loaded granules were compressed into tablets and coated again with pH-sensitive polymers (Eudragit S:Eudragit L=1:1). The multiple-unit tablet was optimized with respect to the granular coating compositions (Eudragit S:Eudragit L:Eudragit RS=5:1:4) and coating level (12...
March 6, 2017: European Journal of Pharmaceutical Sciences
Yanyan Jiang, Sandy Wong, Fan Chen, Teddy Chang, Hongxu Lu, Martina Heide Stenzel
Albumin based nanoparticles are widely used to delivery anti-cancer drug as they promote the accumulation of drugs in tumors. Nanoparticles with surface immobilized albumin are widely described in literature, though mixed nanoparticles with systematically modified ratios between albumin and PEG-based material are less common. In this work, mixed hybrid nanoparticles were prepared by self-assembly of a PEG-based amphiphilic block copolymer together with a polymer-protein conjugate. Poly(oligo(ethylene glycol) methyl ether acrylate)-poly(ε-caprolactone) (POEGMEA-PCL) was prepared by a combination of ring-opening polymerization and reversible addition fragmentation chain transfer (RAFT) polymerization while the polymer-protein conjugate was obtained by reacting poly(ε-caprolactone) with bovine serum albumin (BSA-PCL)...
March 6, 2017: Bioconjugate Chemistry
Jong Han Baek, Hyunju Seol, Kilwon Cho, Hoichang Yang, Jae Kyeong Jeong
ZnO-based oxide films are emerging as high-performance semiconductors for field-effect transistors (FETs) in optoelectronics. Carrier mobility and stability in these FETs are improved by introducing indium (In) and gallium (Ga) cations, respectively. However, the strong trade-off between the mobility and stability, which come from In or Ga incorporation, still limits the widespread use of metal oxide FETs in ultrahigh pixel density and device area-independent flat panel applications. We demonstrated that the incorporation of antimony (Sb) cations in amorphous zinc indium oxide (ZIO) simultaneously enhanced the field-effect mobility (μFET) and electrical stability of the resulting Sb-doped ZIO FETs...
March 14, 2017: ACS Applied Materials & Interfaces
Hanna Cho, Jae Yong Choi, Seung Ha Lee, Jae Hoon Lee, Young-Chul Choi, Young Hoon Ryu, Myoung Sik Lee, Chul Hyoung Lyoo
Early-onset Alzheimer's disease (EOAD) is characterized by greater nonmemory dysfunctions, more rapid progression, and greater hypometabolism and atrophy than late-onset AD (LOAD). We sought to investigate the differences in tau accumulation patterns between early- and late-onset patients with AD and mild cognitive impairment (MCI). In 90 patients who completed (18)F-AV-1451 and (18)F-florbetaben positron emission tomography scans, only 59 amyloid-positive patients (11 EOAD, 10 EOMCI, 21 LOAD, and 17 LOMCI) were included in this study...
February 9, 2017: Neurobiology of Aging
Sujith Kalluri, Moonsu Yoon, Minki Jo, Hua Kun Liu, Shi Xue Dou, Jaephil Cho, Zaiping Guo
Cathode material degradation during cycling is one of the key obstacles to upgrading lithium-ion and beyond-lithium-ion batteries for high-energy and varied-temperature applications. Herein, we highlight recent progress in material surface-coating as the foremost solution to resist the surface phase-transitions and cracking in cathode particles in mono-valent (Li, Na, K) and multi-valent (Mg, Ca, Al) ion batteries under high-voltage and varied-temperature conditions. Importantly, we shed light on the future of materials surface-coating technology with possible research directions...
March 2, 2017: Advanced Materials
So-Min Im, Yoon-Hyuk Huh, Lee-Ra Cho, Chan-Jin Park
PURPOSE: The aim of this study was to investigate the effect of reinforcing materials on the fracture resistances of glass fiber mesh- and Cr-Co metal mesh-reinforced maxillary complete dentures under fatigue loading. MATERIALS AND METHODS: Glass fiber mesh- and Cr-Co mesh-reinforced maxillary complete dentures were fabricated using silicone molds and acrylic resin. A control group was prepared with no reinforcement (n = 15 per group). After fatigue loading was applied using a chewing simulator, fracture resistance was measured by a universal testing machine...
February 2017: Journal of Advanced Prosthodontics
Warren J Bradley, Marcus P Hannon, Victoria Benford, James C Morehen, Craig Twist, Sam Shepherd, Matthew Cocks, Samuel G Impey, Robert G Cooper, James P Morton, Graeme L Close
OBJECTIVES: The metabolic requirements of a rugby league match simulation protocol and the timing of carbohydrate provision on glycogen re-synthesis in damaged muscle were examined. DESIGN: Fifteen (mean±SD: age 20.9±2.9 year, body-mass 87.3±14.1kg, height 177.4±6.0cm) rugby league (RL) players consumed a 6gkgday-1 CHO diet for 7-days, completed a time to exhaustion test (TTE) and a glycogen depletion protocol on day-3, a RL simulated-match protocol (RLMSP) on day-5 and a TTE on day-7...
February 15, 2017: Journal of Science and Medicine in Sport
Jeong Jin Min, Tae Kyong Kim, Jong-Hwan Lee, Jiyeon Park, Hyun Sung Cho, Wook Sung Kim, Young Tak Lee
BACKGROUND: Pulse pressure variation (PPV) is a well known dynamic preload indicator of fluid responsiveness. However, its usefulness in open-chest conditions remains controversial. OBJECTIVE: We evaluated whether augmented PPV during a Valsalva manoeuvre can predict fluid responsiveness after sternotomy. DESIGN: A prospective, observational study. SETTING: Single-centre trial, study period from October 2014 to June 2015...
February 15, 2017: European Journal of Anaesthesiology
Hana Cho, Young-Woo Cho, Sun-Woong Kang, Mi-Kyoung Kwak, Kang Moo Huh, You Han Bae, Han Chang Kang
The clinical application of intracellular gene delivery via nanosized carriers is hindered by intracellular multistep barriers that limit high levels of gene expression. To solve these issues, four different intracellular or external stimuli that can efficiently activate a gene carrier, a gene, or a photosensitizer (pheophorbide A [PhA]) were assessed in this study. The designed nanosized polymeric gene complexes were composed of PhA-loaded thiol-degradable polycation (PhA@RPC) and cytomegalovirus (CMV) promoter-equipped pDNA...
February 23, 2017: Molecular Pharmaceutics
Young Yi, Jae-Ho Cho, Ji-Beom Kim, Jae-Young Kim, Su-Yeon Park, Woo Chun Lee
BACKGROUND: Mobile-bearing total ankle replacement (TAR) enables motion at the tibial implant-polyethylene insert interface. This motion could lead to coronal translation of the talus relative to the tibia and may affect radiographic outcome. We aimed to assess the translation of the talus before and after mobile-bearing TAR to determine whether translation of the talus after TAR is associated with coronal plane alignment of the lower limb and hindfoot as well as to investigate the complications associated with talar translation...
February 15, 2017: Journal of Bone and Joint Surgery. American Volume
Mingming Niu, Ji-Hoon Cho, Kiran Kodali, Vishwajeeth Pagala, Anthony A High, Hong Wang, Zhiping Wu, Yuxin Li, Wenjian Bi, Hui Zhang, Xusheng Wang, Wei Zou, Junmin Peng
Isobaric labeling quantification by mass spectrometry (MS) has emerged as a powerful technology for multiplexed large-scale protein profiling, but measurement accuracy in complex mixtures is confounded by the interference from coisolated ions, resulting in ratio compression. Here we report that the ratio compression can be essentially resolved by the combination of pre-MS peptide fractionation, MS2-based interference detection, and post-MS computational interference correction. To recapitulate the complexity of biological samples, we pooled tandem mass tag (TMT)-labeled Escherichia coli peptides at 1:3:10 ratios and added in ∼20-fold more rat peptides as background, followed by the analysis of two-dimensional liquid chromatography (LC)-MS/MS...
February 22, 2017: Analytical Chemistry
Raquel Vaz Hara, Maria Aparecida Marin-Morales
In recent years concern about the chemical composition of wastewater generated by the oil refining industry has increased, even after its treatment. These wastewaters contain substances that can harm both the entire aquatic ecosystem and the health of any exposed organisms. The aim of this study was to evaluate the genotoxic and mutagenic potentials of the effluent generated by the largest Brazilian petroleum refinery, the effectiveness of the treatments used by the refinery, and whether its effluent can compromise the water quality of the river where it is discarded...
May 2017: Chemosphere
Tae-Gyung Jeong, Jinyong Chun, Byung-Won Cho, Jinwoo Lee, Yong-Tae Kim
The porous carbon matrix is widely recognized to be a promising sulfur reservoir to improve the cycle life by suppressing the polysulfide dissolution in lithium sulfur batteries (LSB). Herein, we synthesized mesocellular carbon foam (MSUF-C) with bimodal mesopore (4 and 30 nm) and large pore volume (1.72 cm(2)/g) using MSUF silica as a template and employed it as both the sulfur reservoir and the conductive agent in the sulfur cathode. Sulfur was uniformly infiltrated into MSUF-C pores by a chemical solution deposition method (MSUF-C/S CSD) and the amount of sulfur loading was achieved as high as 73% thanks to the large pore volume with the CSD approach...
February 6, 2017: Scientific Reports
Mahadeo A Mahadik, Arunprabaharan Subramanian, Jungho Ryu, Min Cho, Jum Suk Jang
Well-defined CdS nanograin-sensitized one-dimensional (1D) Zr:α-Fe2O3 nanostructured arrays with enhanced photoelectrochemical performance are synthesized directly on F-doped SnO2 (FTO) using the hydrothermal method. Owing predominantly to the appropriate photogenerated electron-hole separation and charge collection in 1D Zr:α-Fe2O3 nanorods, hydrothermally deposited CdS/1D Zr:α-Fe2O3 samples exhibit improved photocurrent density over CdS/Fe2O3 nanosheets prepared by other methods. In our work, compared with 1D Zr:α-Fe2O3, the CdS-sensitized 1D Zr:α-Fe2O3 nanorod arrays show 1...
January 31, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
Mona Alibolandi, Seyed Mohammad Taghdisi, Pouria Ramezani, Fazileh Hosseini Shamili, Sara Amel Farzad, Khalil Abnous, Mohammad Ramezani
In the current study camptothecin-loaded pegylated PAMAM dendrimer were synthesized and were functionalized with AS1411 anti-nucleolin aptamers for site-specific targeting against colorectal cancer cells which over expresses nucleolin receptors. The morphological properties and size dispersity of the prepared nanoparticles were evaluated using transmission electron microscope (TEM) and DLS. The drug-loading content and encapsulation efficiency were obtained 8.1% and 93.67% respectively. The in vitro release of camptothecin from the formulation was provided the sustained release of encapsulated camptothecin during 4days...
March 15, 2017: International Journal of Pharmaceutics
Sewha Kim, Sanghui Park, Min Sun Cho, Woosung Lim, Byung-In Moon, Sun Hee Sung
Indoleamine 2,3-dioxygenase 1 (IDO1) is an immunosuppressive enzyme involved in tumor immune escape. Blockade of the IDO1 pathway is an emerging modality of cancer immunotherapy. Triple-negative breast cancer (TNBC) lacks established therapeutic targets and may be a good candidate for this novel immunotherapeutic agent. The purpose of this study was to evaluate the clinicopathologic characteristics of the IDO1-expressing TNBC subset. A tissue microarray was constructed from 200 patients with TNBC. Immunohistochemistry (IHC) for IDO1 and TNBC molecular subtype-surrogate markers (AR, GCDFP-15, claudin-3, E-cadherin, CK5/6, and EGFR) was performed using this tissue microarray...
2017: Journal of Cancer
Dongjun Lv, Mingjie Zhang
Two polymer catalysts (Pd-OCMCS and Ni-OCMCS) with good reusability were synthesized by coordinating Pd and Ni onto O-carboxymethyl chitosan (OCMCS). The chemical structure and thermal stability of prepared catalysts were determined by Fourier transform infrared (FT-IR) spectra, Energy Dispersive Spectrometer (EDS)analysis, X-ray diffraction (XRD), and thermogravimetric analyzer (TG-DTG), and the analysis results showed that the Pd and Ni ions coordinated onto the OCMCS and formed a ligand with the -COOH group, amino groups, and -OH group on the OCMCS, and the EDS and Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES) analysis results showed that the loading amounts of Pd and Ni were approximately 8...
January 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Haneul Kim, Ara Jo, Seulgi Baek, Daeun Lim, Soon-Yong Park, Soo Kyung Cho, Jin Woong Chung, Jinhwan Yoon
Targeted drug delivery has long been extensively researched since drug delivery and release at the diseased site with minimum dosage realizes the effective therapy without adverse side effects. In this work, to achieve enhanced intracellular uptake of anticancer drug carriers for efficient chemo-therapy, we have designed targeted multifunctional anticancer drug carrier hydrogels. Temperature-responsive poly(N-isopropylacrylamide) (PNIPAm) hydrogel core containing superparamagnetic magnetite nanoparticles (MNP) were prepared using precipitation polymerization, and further polymerized with amine-functionalized copolymer shell to facilitate the conjugation of targeting ligand...
January 20, 2017: Scientific Reports
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