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Hao Li, Zhen Jin, Sunghoon Cho, Mi Jeong Jeon, Van Du Nguyen, Jong-Oh Park, Sukho Park
We propose the use of folate-receptor-targeted, near-infrared-sensitive polydopamine nanoparticles (NPs) for chemo-photothermal cancer therapy as an enhanced type of drug-delivery system which can be synthesized by in situ polymerization and conjugation with folic acid. The NPs consist of a Fe3O4/Au core, coated polydopamine, conjugated folic acid, and loaded anti-cancer drug (doxorubicin). The proposed multifunctional NPs show many advantages for therapeutic applications such as good biocompatibility and easy bioconjugation...
September 25, 2017: Nanotechnology
Jason Chow, Simon Pearce, Kuk-Ki Cho, William Walter
The accuracy of cup position in total hip arthroplasty is essential for a satisfactory result as malpositioning increases the risk of complications including dislocation, high wear rate, loosening, squeaking, edge loading, impingement and ultimately failure. We studied 166 patients in a single-surgeon-series of matched cohorts of patients who underwent total hip arthroplasties. Four separate groups were identified comprising of the posterior approach +/- navigation and the direct anterior approach +/- navigation...
July 17, 2017: Curēus
F Schlottmann, M Vera-Aviles, G O Latunde-Dada
Dietary non-heme ferric iron is reduced by the ferric reductase enzyme, duodenal cytochrome b (Dcytb), before absorption by the divalent metal transporter 1 (DMT1). A single nucleotide polymorphism (SNP rs10455 mutant) that is located in the last exon of the Dcytb gene was reported in C282Y haemochromatosis HFE subjects. The present work therefore investigated the phenotype of this mutant Dcytb in Chinese hamster ovary (CHO) cells. These cultured cells were transfected with either wild type (WT) or the SNP vector plasmids of Dcytb...
September 22, 2017: Metallomics: Integrated Biometal Science
Mona Alibolandi, Rouhollah Rezvani, Sara Amel Farzad, Seyed Mohammad Taghdisi, Khalil Abnous, Mohammad Ramezani
In this study, we prepared tetraiodothyroacetic acid (tetrac) conjugated PEG-PLGA polymersomes for the targeted delivery of camptothecin to colon adenocarcinoma. Tetrac, which binds to integrin αvβ3 with high affinity and specificity, was covalently conjugated to the surface of the PEGylated polymersomal formulation of camptothecin (CPT). The hydrodynamic and morphological properties of the prepared system were evaluated using TEM (transmission electron microscopy), SEM (scanning electron microscopy) and DLS (dynamic light scattering) experiments...
September 18, 2017: International Journal of Pharmaceutics
Chae Young Park, Chul Ho Jang, Do Yup Lee, Hyung Taek Cho, Young Jun Kim, Yoo Heon Park, Jee-Young Imm
Vitamin-E-loaded nanoemulsion (Vit E-NE) was produced, and the effects of repeated oral administration of Vit E-NE (2 g/kg/day) for five days on hepatic gene expression and serum metabolites were investigated in rats. The mean particle diameter and zeta potential of Vit E-NE was 112 nm and 56 mV, respectively. Vit E-NE administered rats showed significantly higher triglyceride content than of standard diet (control) or Vit E control emulsion (Vit E-CE) group but no toxicity symptoms were found in blood biochemical analysis...
September 15, 2017: Food and Chemical Toxicology
Jean De La Croix Ndong, Stephenson Yvonne, Michael E Davis, Andrés J García, Steven Goudy
Osteoblast commitment and differentiation are controlled by multiple growth factors including members of the Notch signaling pathway. JAGGED1 is a cell surface ligand of the Notch pathway that is necessary for murine bone formation. The delivery of JAGGED1 to induce bone formation is complicated by its need to be presented in a bound form to allow for proper Notch receptor signaling. In this study we investigate whether the sustained release of JAGGED1 stimulates human mesenchymal cells to commit to osteoblast cell fate using polyethylene glycol malemeide (PEG-MAL) hydrogel delivery system...
September 15, 2017: Journal of Biomedical Materials Research. Part A
Dong-Min Kim, Yu-Jin Cho, Ju-Young Choi, Beom-Jun Kim, Seung-Won Jin, Chan-Moon Chung
Low-temperature self-healing capabilities are essential for self-healing materials exposed to cold environments. Although low-temperature self-healing concepts have been proposed, there has been no report of a microcapsule-type low-temperature self-healing system wherein the healing ability was demonstrated at low temperature. In this work, low-temperature self-healing of a microcapsule-type protective coating was demonstrated. This system employed silanol-terminated polydimethylsiloxane (STP) as a healing agent and dibutyltin dilaurate (DD) as a catalyst...
September 14, 2017: Materials
Sung Hun Kang, Vishnu Revuri, Sang-Joon Lee, Sungpil Cho, In-Kyu Park, Kwang Jae Cho, Woo Kyun Bae, Yong-Kyu Lee
Convenient multiple dosing makes oral administration an ideal route for delivery of therapeutic siRNA. However, hostile GI environments and non-specific biological trafficking prevent from achieving appropriate bioavailability of siRNA. Here, an orally administered AuNP-siRNA-glycol chitosan-taurocholic acid nanoparticle (AR-GT NPs), was developed to selectively deliver Akt2 siRNA and treat colorectal liver metastases (CLM). AR-GT NPs are dual padlocked non-viral vectors in which the initially formed AuNP-siRNA (AR) conjugates are further encompassed by bifunctional glycol chitosan-taurocholic acid (GT) conjugates...
September 13, 2017: ACS Nano
Derek T Holyoak, Miguel Otero, Naa Shidaa Armar, Sophia N Ziemian, Ariana Otto, Devinne Cullinane, Timothy M Wright, Steven R Goldring, Mary B Goldring, Marjolein C H van der Meulen
Interactions among risk factors for osteoarthritis (OA) are not well understood. We investigated the combined impact of two prevalent risk factors: mechanical loading and genetically abnormal cartilage tissue properties. We used cyclic tibial compression to simulate mechanical loading in the cho/+ (Col11a1 haploinsufficient) mouse, which has abnormal collagen fibrils in cartilage due to a point mutation in the Col11a1 gene. We hypothesized that the mutant collagen would not alter phenotypic bone properties and that cho/+ mice, which develop early onset OA, would develop enhanced load-induced cartilage damage compared to their littermates...
September 12, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Hohyun Cho, Min-Koo Kang, Sangtae Ahn, Moonyoung Kwon, Kuk-Jin Yoon, Kiwoong Kim, Sung Chan Jun
Due to the recent explosion in various forms of 3D content, the evaluation of such content from a neuroscience perspective is quite interesting. However, existing investigations of cortical oscillatory responses in stereoscopic depth perception are quite rare. Therefore, we investigated spatiotemporal and spatio-temporo-spectral features at four different stereoscopic depths within the comfort zone. We adopted a simultaneous EEG/MEG acquisition technique to collect the oscillatory responses of eight participants...
2017: Journal of Integrative Neuroscience
Sukhwinder K Bhullar, Deepti Rana, Huseyin Lekesiz, Ayse Celik Bedeloglu, Junghyuk Ko, Yonghyun Cho, Zeynep Aytac, Tamer Uyar, Martin Jun, Murugan Ramalingam
The main objective of this study was to fabricate poly (ε-caprolactone) (PCL)-based auxetic nanofiber membranes and characterize them for their mechanical and physicochemical properties. As a first step, the PCL nanofibers were fabricated by electrospinning with two different thicknesses of 40μm (called PCL thin membrane) and 180μm (called PCL thick membrane). In the second step, they were tailored into auxetic patterns using femtosecond laser cut technique. The physicochemical and mechanical properties of the auxetic nanofiber membranes were studied and compared with the conventional electrospun PCL nanofibers (non-auxetic nanofiber membranes) as a control...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
Jin-Woo Park, Kyoung-Tae Kim, Joo-Kyung Sung, Seong-Hyun Park, Ki-Woong Seong, Dae-Chul Cho
OBJECTIVE: The purpose of the present study was to compare inter-fragmentary compression pressures after fixation of a simulated type II odontoid fracture with the headless compression Herbert screw and a half threaded cannulated lag screw. METHODS: We compared inter-fragmentary compression pressures between 40- and 45-mm long 4.5-mm Herbert screws (n=8 and n=9, respectively) and 40- and 45-mm long 4.0-mm cannulated lag screws (n=7 and n=10, respectively) after insertion into rigid polyurethane foam test blocks (Sawbones, Vashon, WA, USA)...
September 2017: Journal of Korean Neurosurgical Society
Ahreum Kim, Yun-Gyoung Hur, Sunwha Gu, Sang-Nae Cho
The aim of this study was to evaluate the protective efficacy of MTBK_24820, a complete form of PPE39 protein derived from a predominant Beijing/K strain of Mycobacterium tuberculosis in South Korea. Mice were immunized with MTKB_24820, M. bovis Bacilli Calmette-Guérin, or adjuvant prior to a high-dosed Beijing/K strain aerosol infection. After 4 and 9 weeks, bacterial loads were determined and histopathologic and immunologic features in the lungs and spleens of the M. tb-infected mice were analyzed. Putative immunogenic T-cell epitopes were examined using synthetic overlapping peptides...
September 6, 2017: Clinical and Vaccine Immunology: CVI
Ji-Hye Lee, Won Lee, Yoon-Hyuk Huh, Chan-Jin Park, Lee-Ra Cho
PURPOSE: To evaluate the axial displacement of the implant-abutment assembly of different implant diameter after static and cyclic loading of overload condition. MATERIALS AND METHODS: An internal conical connection system with three diameters (Ø 4.0, 4.5, and 5.0) applying identical abutment dimension and the same abutment screw was evaluated. Axial displacement of abutment and reverse torque loss of abutment screw were evaluated under static and cyclic loading conditions...
September 5, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
Abkar Sayad, Fatimah Ibrahim, Shah Mukim Uddin, Jongman Cho, Marc Madou, Kwai Lin Thong
Outbreaks of foodborne diseases have become a global health concern; hence, many improvements and developments have been made to reduce the risk of food contamination. We developed a centrifugal microfluidic automatic wireless endpoint detection system integrated with loop mediated isothermal amplification (LAMP) for monoplex pathogen detection. Six identical sets were designed on the microfluidic compact disc (CD) to perform 30 genetic analyses of three different species of foodborne pathogens. The consecutive loading, mixing, and aliquoting of the LAMP primers/reagents and DNA sample solutions were accomplished using an optimized square-wave microchannel, metering chambers and revulsion per minute (RPM) control...
August 31, 2017: Biosensors & Bioelectronics
Bo-Sik Kim, Young-Guk Na, Jae-Hwan Choi, Inhye Kim, Eunji Lee, Sung-Yeon Kim, Jae-Young Lee, Cheong-Weon Cho
Phenylethyl resorcinol (4-(1-phenylethyl)1,3-benzenediol) (PR) is a new whitening agent that has been found to have the ability to inhibit tyrosinase activity. However, the application of PR is limited by photo instability and poor solubility. PR-loaded nanostructured lipid carriers (PR-NLCs) were prepared by the hot-melted ultrasonic method. Glycerol monostearate and olive oil were selected as the solid lipid and liquid lipid for considering the solubility of PR in liquid lipid and partition coefficient of PR in solid lipid, respectively...
August 28, 2017: Nanomaterials
Keunhee Cho, Sung Tae Kim, Jeong-Rae Cho, Young-Hwan Park
Unlike conventional steel strands, the smart strand supports strain-measuring function and adopts different materials for its core wire and helical wires. This study intends to analytically derive the nonlinear stress-strain model of this strand made of two materials. The effect of the bending moment and torsional moment of the helical wires on the overall load within the range of geometric shapes shown by actually used strands is verified to be negligible and is thus ignored in order to simplify the analytical model...
August 28, 2017: Materials
Si-Kyung Cho, Kyung-Won Jung, Dong-Hoon Kim, Joong-Chun Kwon, Umer Zeeshan Ijaz, Seung Gu Shin
A novel anaerobic digestion configuration, the upflow multi-layer anaerobic reactor (UMAR), was developed to treat high-solids organic wastes. The UMAR was hypothesized to form multi-layer along depth due to the upflow plug flow; use of a recirculation system and a rotating distributor and baffles aimed to assist treating high-solids influent. The chemical oxygen demand (COD) removal efficiency and methane (CH4 ) production rate were 89% and 2.10 L CH4 /L/day, respectively, at the peak influent COD concentration (110...
August 25, 2017: Biotechnology Progress
Hossein Mokhtarzadeh, Chen Hua Yeow, James Cho Hong Goh, Denny Oetomo, Katie Ewing, Peter Vee Sin Lee
BACKGROUND: Knee injuries are common during landing activities. Greater landing height increases peak ground reaction forces (GRFs) and loading at the knee joint. As major muscles to stabilize the knee joint, Quadriceps and Hamstring muscles provide internal forces to attenuate the excessive GRF. Despite the number of investigations on the importance of muscle function during landing, the role of landing height on these muscles forces using modeling during landing is not fully investigated...
August 24, 2017: Computer Methods in Biomechanics and Biomedical Engineering
Benjamin Maasoumy, Birgit Bremer, Patrick Lehmann, Ed G Marins, Véronique Michel-Treil, Christian O Simon, Merlin Njoya, Markus Cornberg, Ellen Paxinos, Michael P Manns, Johannes Vermehren, Christoph Sarrazin, Ji Yeon Sohn, Yunjung Cho, Heiner Wedemeyer
BACKGROUND: HBV DNA is the most important molecular marker in hepatitis B, used to determine treatment indication and monitoring. Most patients require lifelong hepatitis B virus (HBV) management, thus viral load (VL) monitoring may be performed at different laboratories, with different HBV assays, which may result in different VL results. This multicenter study compares the commutability and concordance of results from four different HBV DNA assays: CAP/CTM HBVv2, HPS/CTM HBVv2 and the new cobas 6800/8800 HBV and cobas 4800 HBV assays...
August 2017: Therapeutic Advances in Gastroenterology
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