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https://www.readbyqxmd.com/read/29338573/triphenylphosphine-docetaxel-conjugate-incorporated-albumin-nanoparticles-for-cancer-treatment
#1
Gantumur Battogtokh, Oyuntuya Gotov, Jee He Kang, Jinsung Cho, Tae Ho Jeong, Ganzorig Chimed, Young Tag Ko
AIM: The objective of this study was to develop a mitochondria-targeted anticancer drug, docetaxel (DTX), for chemotherapy. MATERIALS & METHODS: The DTX was conjugated to 4-carboxybutyl triphenylphosphonium (TPP) to enhance mitochondrial targeting, and the TPP-DTX conjugate was further loaded into folate-cholesteryl albumin (FA-chol-BSA) nanoparticles (NPs) to improve its biocompatibility. RESULTS & CONCLUSION: In vitro studies showed that TPP-DTX and its NP primarily accumulated in the mitochondria; generated high reactive oxygen species, leading to mitochondrial disruption and cell apoptosis; and had a higher cytotoxicity against cancer cells...
January 17, 2018: Nanomedicine
https://www.readbyqxmd.com/read/29334430/preclinical-therapeutic-efficacy-of-the-ciprofloxacin-eluting-sinus-stent-for-pseudomonas-aeruginosa-sinusitis
#2
Do-Yeon Cho, Dong-Jin Lim, Calvin Mackey, Daniel Skinner, Christopher Weeks, Gobind S Gill, Robert W Hergenrother, William E Swords, Bradford A Woodworth
BACKGROUND: The ciprofloxacin-coated sinus stent (CSS) has unique therapeutic potential to deliver antibiotics to the sinuses. The objective of this study is to evaluate the efficacy of the CSS stent in eliminating Pseudomonas aeruginosa infection in a rabbit model of sinusitis. METHODS: A ciprofloxacin-eluting sinus stent was created by coating ciprofloxacin/Eudragit RS100 on biodegradable poly-D/L-lactic acid (2 mg). After analyzing in-vitro inhibition of P aeruginosa (PAO-1 strain) biofilm formation, a total of 8 stents (4 shams, 4 CSSs) were placed unilaterally in rabbit maxillary sinuses via dorsal sinusotomy after inducing infection for 1 week with PAO-1...
January 15, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29324401/unblinded-randomized-multicenter-trial-comparing-lamotrigine-and-valproate-combination-with-controlled-release-carbamazepine-monotherapy-as-initial-drug-regimen-in-untreated-epilepsy
#3
Byung In Lee, Soon Kee No, Sang-Doe Yi, Hyang Woon Lee, Ok Joon Kim, Sang Ho Kim, Myeong Kyu Kim, Sung Eun Kim, Yo Sik Kim, Jae Moon Kim, Se-Jin Lee, Dong Jin Shin, Sung Pa Park, Yeong In Kim, Kyoung Heo, Yong Won Cho, Yang-Je Cho, Youn Nam Kim
PURPOSE: To compare controlled-release carbamazepine monotherapy (CBZ-CR) with lamotrigine and valproate combination therapy (LTG + VPA) in equivalent total drug load, as initial drug regimen in untreated patients with partial and/or generalized tonic-clonic seizures (GTCS). METHODS: This unblinded, randomized, 60-week superiority trial recruited patients having two or more unprovoked seizures with at least one seizure during previous three months. After randomization into CBZ-CR or LTG + VPA, patients entered into eight-week titration phase (TP), followed by 52-week maintenance phase (MP)...
December 29, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29316069/entecavir-and-tenofovir-reduce-hepatitis-b-virus-related-hepatocellular-carcinoma-recurrence-more-effectively-than-other-antivirals
#4
Hyeki Cho, Hongkeun Ahn, Dong Hyeon Lee, Jeong-Hoon Lee, Yong Jin Jung, Young Chang, Joon Yeul Nam, Young Youn Cho, Dong Ho Lee, Eun Ju Cho, Su Jong Yu, Jeong Min Lee, Yoon Jun Kim, Jung-Hwan Yoon
Nucleos(t)ide analogues (NAs) have been shown to decrease the risk of hepatocellular carcinoma (HCC) recurrence. This study evaluated whether high-potency NAs (entecavir and tenofovir disoproxil fumarate [TDF]) reduce the risk of tumor recurrence more potently than low-potency NAs after curative treatment of hepatitis B virus (HBV)-related HCC. This study included 607 consecutive HBV-related HCC patients treated with surgical resection or radiofrequency ablation. The patients were categorized into three groups according to antiviral treatment: group A (no antiviral; n=261), group B (low-potency NA; n=90), and group C (high-potency NA; n=256)...
January 6, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29311039/sodium-reduced-meat-and-poultry-products-contain-a-significant-amount-of-potassium-from-food-additives
#5
Arti Sharma Parpia, Marc B Goldstein, JoAnne Arcand, France Cho, Mary R L'Abbé, Pauline B Darling
BACKGROUND: Sodium-reduced packaged food products are increasingly available to consumers; however, it is not clear whether they are suitable for inclusion in a potassium-reduced diet. For individuals with impaired renal potassium excretion caused by chronic kidney disease and for those taking certain medications that interfere with the rennin-angiotensin aldosterone axis, the need to limit dietary potassium is important in view of the risk for development of hyperkalemia and fatal cardiac arrhythmias...
January 6, 2018: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/29306077/the-e3-ubiquitin-ligase-hectd1-is-involved-in-abca1-mediated-cholesterol-export-from-macrophages
#6
Shereen M Aleidi, Alryel Yang, Laura J Sharpe, Geetha Rao, Blake J Cochran, Kerry-Anne Rye, Maaike Kockx, Andrew J Brown, Ingrid C Gelissen
The ABC lipid transporters, ABCA1 and ABCG1, are essential for maintaining lipid homeostasis in cells such as macrophages by exporting excess cholesterol to extracellular acceptors. These transporters are highly regulated at the post-translational level, including protein ubiquitination. Our aim was to investigate the role of the E3 ubiquitin ligase HECTD1, recently identified as associated with ABCG1, on ABCG1 and ABCA1 protein levels and cholesterol export function. Here, we show that HECTD1 protein is widely expressed in a range of human and murine primary cells and cell lines, including macrophages, neuronal cells and insulin secreting β-cells...
January 3, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29301367/metabolic-responses-to-carbohydrate-ingestion-during-exercise-associations-between-carbohydrate-dose-and-endurance-performance
#7
Michael L Newell, Gareth A Wallis, Angus M Hunter, Kevin D Tipton, Stuart D R Galloway
Carbohydrate (CHO) ingestion during exercise lasting less than three hours improves endurance exercise performance but there is still debate about the optimal dose. We utilised stable isotopes and blood metabolite profiles to further examine metabolic responses to CHO (glucose only) ingestion in the 20-64 g·h-1 range, and to determine the association with performance outcome. In a double-blind, randomized cross-over design, male cyclists (n = 20, mean ± SD, age 34 ± 10 years, mass 75.8 ± 9 kg, peak power output 394 ± 36 W, VO2max 62 ± 9 mL·kg-1·min-1) completed four main experimental trials...
January 3, 2018: Nutrients
https://www.readbyqxmd.com/read/29300434/postprandial-metabolic-responses-differ-by-age-group-and-physical-activity-level
#8
S R Emerson, S P Kurti, E M Emerson, B J Cull, K Casey, M D Haub, S K Rosenkranz
OBJECTIVES: To compare the postprandial metabolic responses to a high-fat meal in healthy adults who differ by age and physical activity level. DESIGN: Cross-sectional, quasi-experimental design. SETTING: Physical Activity and Nutrition Clinical Research Consortium (PAN-CRC) at Kansas State University (Manhattan, KS, USA). PARTICIPANTS: Twenty-two healthy adults: 8 younger active (YA) adults (4M/4W; 25 ± 5 yr), 8 older active (OA) adults (4M/4W; 67 ± 5 yr), and 6 older inactive (OI) adults (3M/3W; 68 ± 7 yr)...
2018: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29300088/spherical-macroporous-carbon-nanotube-particles-with-ultrahigh-sulfur-loading-for-lithium-sulfur-battery-cathodes
#9
Donghee Gueon, Jeong Tae Hwang, Seung Bo Yang, Eunkyung Cho, Kwonnam Sohn, Doo-Kyung Yang, Jun Hyuk Moon
A carbon host capable of effective and uniform sulfur loading is the key for lithium-sulfur batteries (LSBs). Despite the application of porous carbon materials of various morphologies, the carbon hosts capable of uniformly impregnating highly active sulfur is still challenging. To address this issue, we demonstrate a hierarchical pore-structured CNT particle host containing spherical macropores of several hundred nanometers. The macropore CNT particles (M-CNTPs) are prepared by drying the aerosol droplets in which CNTs and polymer particles are dispersed...
January 4, 2018: ACS Nano
https://www.readbyqxmd.com/read/29281044/radiobiological-response-of-u251mg-cho-k1-and-v79-cell-lines-to-accelerator-based-boron-neutron-capture-therapy
#10
Eisuke Sato, Alexander Zaboronok, Tetsuya Yamamoto, Kei Nakai, Sergey Taskaev, Olga Volkova, Ludmila Mechetina, Alexander Taranin, Vladimir Kanygin, Tomonori Isobe, Bryan J Mathis, Akira Matsumura
In the current article, we provide in vitro efficacy evaluation of a unique accelerator-based neutron source, constructed at the Budker Institute of Nuclear Physics (Novosibirsk, Russian Federation), for boron neutron capture therapy (BNCT), which is particularly effective in the case of invasive cancers. U251MG, CHO-K1 and V79 cells were incubated and irradiated in various concentrations of boric acid with epithermal neutrons for 2-3 h in a plexiglass phantom, using 2.0 MeV proton energy and 1.5-3.0 mA proton current, resulting in a neutron fluence of 2...
December 21, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/29280279/issues-and-challenges-facing-flexible-lithium-ion-batteries-for-practical-application
#11
REVIEW
Hyungyeon Cha, Junhyeok Kim, Yoonji Lee, Jaephil Cho, Minjoon Park
With the advent of flexible electronics, lithium-ion batteries have become a key component of high performance energy storage systems. Thus, considerable effort is made to keep up with the development of flexible lithium-ion batteries. To date, many researchers have studied newly designed batteries with flexibility, however, there are several significant challenges that need to be overcome, such as degradation of electrodes under external load, poor battery performance, and complicated cell preparation procedures...
December 27, 2017: Small
https://www.readbyqxmd.com/read/29250950/fundamental-study-of-facile-and-stable-hydrogen-evolution-reaction-at-electrospun-ir-and-ru-mixed-oxide-nanofibers
#12
Yun-Bin Cho, Areum Yu, Chongmok Lee, Myung Hwa Kim, Youngmi Lee
Electrochemical hydrogen evolution reaction (HER) has been an interesting research topic in terms of the increasing need of renewable and alternative energy conversion devices. In this paper, IrxRu1-xOy (y = 0 or 2) nanofibers with diverse compositions of Ir/IrO2 and RuO2 are synthesized by electrospinning and calcination procedures. Their HER activities are measured in 1.0 M NaOH. Interestingly, the HER activities of IrxRu1-xOy nanofibers improve gradually during repetitive cathodic potential scans for HER, and then eventually reach the steady-state consistencies...
December 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29236057/development-of-houttuynia-cordata-extract-loaded-solid-lipid-nanoparticles-for-oral-delivery-high-drug-loading-efficiency-and-controlled-release
#13
Ju-Heon Kim, Jong-Suep Baek, Jin-Kyu Park, Bong-Joo Lee, Min-Soo Kim, Sung-Joo Hwang, Jae-Young Lee, Cheong-Weon Cho
Houttuynia cordata (H. cordata) has been used for diuresis and detoxification in folk medicine as well as a herbal medicine with antiviral and antibacterial activities. H. cordata extract-loaded solid lipid nanoparticles (H-SLNs) were prepared with various concentration of poloxamer 188 or poloxamer 407 by a hot homogenization and ultrasonication method. H-SLNs dispersion was freeze-dried with or without trehalose as a cryoprotectant. The physicochemical characteristics of H-SLNs were evaluated by dynamic laser scattering (DLS), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FT-IR), and scanning electron microscopy (SEM)...
December 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29234060/heat-killed-lactobacillus-casei-confers-broad-protection-against-influenza-a-virus-primary-infection-and-develops-heterosubtypic-immunity-against-future-secondary-infection
#14
Yu-Jin Jung, Young-Tae Lee, Vu Le Ngo, Young-Hee Cho, Eun-Ju Ko, Sung-Moon Hong, Ki-Hye Kim, Ji-Hun Jang, Joon-Suk Oh, Min-Kyung Park, Cheol-Hyun Kim, Jun Sun, Sang-Moo Kang
Lactic acid bacteria (LAB) are the common probiotics. Here, we investigated the antiviral protective effects of heat-killed LAB strain Lactobacillus casei DK128 (DK128) on influenza viruses. Intranasal treatment of mice with DK128 conferred protection against different subtypes of influenza viruses by lessening weight loss and lowering viral loads. Protection via heat-killed DK128 was correlated with an increase in alveolar macrophage cells in the lungs and airways, early induction of virus specific antibodies, reduced levels of pro-inflammatory cytokines and innate immune cells...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29226554/controllable-solid-electrolyte-interphase-in-nickel-rich-cathodes-by-an-electrochemical-rearrangement-for-stable-lithium-ion-batteries
#15
Junhyeok Kim, Jieun Lee, Hyunsoo Ma, Hu Young Jeong, Hyungyeon Cha, Hyomyung Lee, Youngshin Yoo, Minjoon Park, Jaephil Cho
The layered nickel-rich materials have attracted extensive attention as a promising cathode candidate for high-energy density lithium-ion batteries (LIBs). However, they have been suffering from inherent structural and electrochemical degradation including severe capacity loss at high electrode loading density (>3.0 g cm-3 ) and high temperature cycling (>60 °C). In this study, an effective and viable way of creating an artificial solid-electrolyte interphase (SEI) layer on the cathode surface by a simple, one-step approach is reported...
December 11, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29214921/heteropterys-tomentosa-a-juss-toxicological-and-adaptogenic-effects-in-experimental-models
#16
Géssica Alves Fraga, Sikiru Olaitan Balogun, Emilly Della Pascqua, Ruberlei Godinho de Oliveira, Guilherme Botelho, Eduarda Pavan, Thiago da Rosa Lima, Eudes Thiago Pereira Avila, Clarissa de Medeiros Amorim Krueger, Valdir Cechinel Filho, Amílcar Sabino Damazo, Domingos Tabajara de Oliveira Martins, Fabrício Azevedo Voltarelli
BACKGROUND: The constant pursuit of improved athletic performance characterizes high-performance sport and the use of medicinal plants as dietary supplements is becoming widespread among athletes to enhance long-term endurance performance. AIM: The present study evaluated the toxicity of Heteropterys tomentosa (HEHt) and its acute adaptogenic effects. METHODS: The in vitro safety profile was evaluated on CHO-k1 cells using the alamar Blue assay, at concentrations ranging from 3...
December 2017: Nutrition and Health
https://www.readbyqxmd.com/read/29212047/whole-brain-neuronal-abnormalities-in-focal-quantified-with-proton-mr-spectroscopy
#17
Ivan I Kirov, Ruben Kuzniecky, Hoby P Hetherington, Brian J Soher, Matthew S Davitz, James S Babb, Heath R Pardoe, Jullie W Pan, Oded Gonen
OBJECTIVE: To test the hypothesis that localization-related epilepsy is associated with widespread neuronal dysfunction beyond the ictal focus, reflected by a decrease in patients' global concentration of their proton MR spectroscopy (1H-MRS) observed marker, N-acetyl-aspartate (NAA). METHODS: Thirteen patients with localization-related epilepsy (7 men, 6 women) 40±13 (mean±standard-deviation)years old, 8.3±13.4years of disease duration; and 14 matched controls, were scanned at 3 T with MRI and whole-brain (WB) 1H MRS...
December 2, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29205030/crack-enhanced-microfluidic-stretchable-e-skin-sensor
#18
Dong Hae Ho, Ryun Geun Song, Qijun Sun, Won-Hyeong Park, So Young Kim, Changhyun Pang, Do Hwan Kim, Sang-Youn Kim, Jinkee Lee, Jeong Ho Cho
We reported the development of a transparent stretchable crack-enhanced microfluidic capacitive sensor array for use in E-skin applications. The microfluidic sensor was fabricated through a simple lamination process involving two silver nanowire (AgNW)-embedded rubbery microfluidic channels arranged in a crisscross fashion. The sensing performance was optimized by testing a variety of sensing liquids injected into the channels. External mechanical stimuli applied to the sensor induced the liquid to penetrate the deformed micro cracks on the rubber channel surface...
December 5, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29201305/biomechanical-comparison-study-of-three-fixation-methods-for-proximal-chevron-osteotomy-of-the-first-metatarsal-in-hallux-valgus
#19
Jin Su Kim, Hun Ki Cho, Ki Won Young, Ji Soo Kim, Kyung Tai Lee
Background: Fixation of proximal chevron metatarsal osteotomy has been accomplished using K-wires traditionally and with a locking plate recently. However, both methods have many disadvantages. Hence, we developed an intramedullary fixation technique using headless cannulated screws and conducted a biomechanical study to evaluate the superiority of the technique to K-wire and locking plate fixations. Methods: Proximal chevron metatarsal osteotomy was performed on 30 synthetic metatarsal models using three fixation techniques...
December 2017: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/29194870/delayed-viral-suppression-during-antiviral-therapy-is-associated-with-increased-hepatocellular-carcinoma-rates-in-hbeag-positive-high-viral-load-chronic-hepatitis-b
#20
Joon Yeul Nam, Young Chang, Hyeki Cho, Seong Hee Kang, Young Youn Cho, Eun Ju Cho, Jeong-Hoon Lee, Su Jong Yu, Jung-Hwan Yoon, Yoon Jun Kim
The treatment option in chronic hepatitis B (CHB) patients with persistent low-level viremia despite entecavir or tenofovir monotherapy is unclear. This study investigated the development of hepatocellular carcinoma (HCC) or cirrhosis in hepatitis B e antigen (HBeAg) positive high viral load CHB patients, according to the time needed to achieve complete viral suppression. A total of 325 HBeAg-positive CHB patients with high viral load who were recently started on antiviral therapy with entecavir or tenofovir were included...
December 1, 2017: Journal of Viral Hepatitis
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