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https://www.readbyqxmd.com/read/28087146/pcv13-vaccinated-children-still-carrying-pcv13-additional-serotypes-show-similar-carriage-density-to-a-control-group-of-pcv7-vaccinated-children
#1
Ron Dagan, Christine Juergens, James Trammel, Scott Patterson, David Greenberg, Noga Givon-Lavi, Nurith Porat, William C Gruber, Daniel A Scott
BACKGROUND: In addition to reducing vaccine-type nasopharyngeal carriage rates, pneumococcal conjugate vaccines (PCVs) may decrease carriage density in vaccinated individuals still carrying vaccine serotypes. However, reduction of carriage density has not been systematically studied. This study compared the effect of PCV13 versus PCV7 on carriage density of the serotypes in PCV13 that are not included in PCV7. METHODS: This randomized, double-blind study was conducted in southern Israel and included Jewish and Bedouin subjects...
January 10, 2017: Vaccine
https://www.readbyqxmd.com/read/28067713/widespread-down-regulation-of-cardiac-mitochondrial-and-sarcomeric-genes-in-patients-with-sepsis
#2
Scot J Matkovich, Belal Al Khiami, Igor R Efimov, Sarah Evans, Justin Vader, Ashwin Jain, Bernard H Brownstein, Richard S Hotchkiss, Douglas L Mann
OBJECTIVES: The mechanism(s) for septic cardiomyopathy in humans is not known. To address this, we measured messenger RNA alterations in hearts from patients who died from systemic sepsis, in comparison to changed messenger RNA expression in nonfailing and failing human hearts. DESIGN: Identification of genes with altered abundance in septic cardiomyopathy, ischemic heart disease, or dilated cardiomyopathy, in comparison to nonfailing hearts. SETTING: ICUs at Barnes-Jewish Hospital, St...
January 6, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28039189/factor-xi-deficiency-is-associated-with-decreased-risk-for-cardiovascular-and-venous-thromboembolism-events
#3
Meir Preis, Julianna Hirsch, Antonio Kotler, Ahmad Zoabi, Nili Stein, Gad Rennert, Walid Saliba
Factor XI deficiency is one of the rare inherited coagulation factor deficiencies. However, it incidence is high among Ashkenazi Jewish. Because factor XI displays both procoagulant and antifibrinolytic activities, it has been postulated that an underlying cardiovascular benefit may exist with factor XI deficiency. This historical cohort study was performed using the electronic database of Clalit Health Services, the largest health care provider in Israel. All adults tested for Factor XI activity between 2002 and 2014 were included in the study...
December 30, 2016: Blood
https://www.readbyqxmd.com/read/28035592/research-participants-preferences-for-hypothetical-secondary-results-from-genomic-research
#4
Julia Wynn, Josue Martinez, Jimmy Duong, Codruta Chiuzan, Jo C Phelan, Abby Fyer, Robert L Klitzman, Paul S Appelbaum, Wendy K Chung
Secondary or incidental results can be identified in genomic research that increasingly uses whole exome/genome sequencing. Understanding research participants' preferences for secondary results and what influences these decisions is important for patient education, counseling, and consent, and for the development of policies regarding return of secondary results. Two hundred nineteen research participants enrolled in genomic studies were surveyed regarding hypothetical preferences for specific types of secondary results, and these preferences were correlated with demographic information and psychosocial data...
December 29, 2016: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/28029200/the-influence-of-helicobacter-pylori-on-the-ethnic-distribution-of-esophageal-eosinophilia
#5
Amnon Sonnenberg, Evan S Dellon, Kevin O Turner, Robert M Genta
BACKGROUND: Environmental factors associated with ethnicity may contribute to the occurrence of eosinophilic esophagitis. Our study aimed to investigate the influence of Helicobacter pylori on the ethnic variation of esophageal eosinophilia in a large national sample of patients undergoing esophago-gastro-duodenoscopy. METHODS: The Miraca Life Sciences Database is an electronic repository of histopathologic patient records. A case-control study evaluated the influence of ethnicity on the occurrence of esophageal eosinophilia and how age, gender, and histologic diagnosis of H...
December 28, 2016: Helicobacter
https://www.readbyqxmd.com/read/28027113/methotrimeprazine-associated-stevens-johnson-syndrome-in-2-ashkenazi-jewish-patients
#6
Dina Moubayed, Anthony J Gifuni, Leon Tourian
No abstract text is available yet for this article.
February 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28024842/congenital-myasthenic-syndrome-in-israel-genetic-and-clinical-characterization
#7
Sharon Aharoni, Menachem Sadeh, Yehuda Shapira, Simon Edvardson, Muhannad Daana, Talia Dor-Wollman, Aviva Mimouni-Bloch, Ayelet Halevy, Rony Cohen, Liora Sagie, Zohar Argov, Malcolm Rabie, Ronen Spiegel, Ilana Chervinsky, Naama Orenstein, Andrew G Engel, Yoram Nevo
The objective of the study was to evaluate the epidemiology of patients with congenital myasthenic syndrome (CMS) in Israel. Targeted mutation analysis was performed based on the clinical symptoms and electrophysiological findings for known CMS. Additional specific tests were performed in patients of Iranian and/or Iraqi Jewish origin. All medical records were reviewed and clinical data, genetic mutations and outcomes were recorded. Forty-five patients with genetic mutations in known CMS genes from 35 families were identified...
November 24, 2016: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/28018258/through-the-looking-glass-the-role-of-ethnicity-and-affiliation-in-responses-to-terrorism-in-the-media
#8
Anat Shoshani, Michelle Slone
This study examined whether attitudinal and emotional responses to broadcasts of images of terrorist events differ according to ethnic group (Jewish and Arab Israelis) and outgroup affiliation during an intense wave of terrorism that occurred in Israel during 2015. Participants were 118 Jewish and 110 Arab-Israelis adults randomly allocated to a terrorism or criminal violence television broadcast. State anxiety, state anger, stereotypes, and negative attitudes toward an adversary were examined prior and subsequent to the media exposure...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/28012950/a-dose-effect-of-mutations-in-the-gba-gene-on-parkinson-s-disease-phenotype
#9
Avner Thaler, Tanya Gurevich, Anat Bar Shira, Mali Gana Weisz, Elissa Ash, Tamara Shiner, Avi Orr-Urtreger, Nir Giladi, Anat Mirelman
OBJECTIVE: Mutations in the GBA gene are associated with Parkinson's disease (PD). A definite description of the clinical characteristics of PD patients who are compound heterozygotes or homozygotes for mutations in the GBA gene (GD-PD) requires further elucidation. METHODS: We assessed motor, cognitive, olfactory and autonomic functions as well as demographic data and medical history in a cohort of Ashkenazi Jewish PD patients who were screened for seven common mutations in the GBA gene...
December 16, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28008580/-salomon-neumann-1819-1908-and-the-right-to-health
#10
J G Gostomzyk, G von Mittelstaedt
The "Universal Declaration of Human Rights (UDHR)" of the United Nations (UN) of 1948 sets out a right to health as a common ideal and aspiration. In his writings on the reform of the Prussian Medical Charter "Public Health and property" 100 years before the UDHR was set out, the Jewish physician Salomon Neumann had defined health as a right for every citizen, a right that should to be protected by a public system of health care. His reasoning went beyond contemporaneous critical social discussion. Right of humans to health has been acknowledged nationally and internationally; in the Federal Republic of Germany, the question as to whether there is a basic right to health is still open...
December 2016: Das Gesundheitswesen
https://www.readbyqxmd.com/read/28002332/the-association-of-the-mthfr-c677t-polymorphism-with-inflammatory-bowel-diseases-in-the-israeli-jewish-population-an-example-of-genetic-heterogeneity
#11
Amir Karban, Tzah Feldman, Matti Waterman, Ronit Leiba, Edna Efrati
MTHFR C677T is a common gene polymorphism that has been shown to be associated with hyperhomocysteinemia. Studies on the role of MTHFR in inflammatory bowel diseases (IBD) have yielded conflicting results, perhaps due in part to genetic heterogeneity. The prevalence of the MTHFR C677T variant allele varies according to Jewish subpopulations: Ashkenazi vs non-Ashkenazi. The aim of this study was to examine the association between MTHFR C677T genotype and IBD in the different Jewish populations.DNA samples were assessed for the presence of the MTHFR C677T variant allele in 445 Jewish Israeli IBD patients: 338 with Crohn's disease [CD] (214 Ashkenazi and 124 non-Ashkenazi Jews) and 107 with ulcerative colitis [UC] (73 Ashkenazi and 34 non-Ashkenazi Jews), and in 347 healthy controls: 173 Ashkenazi and 174 Non-Ashkenazi Jews...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28000699/absence-of-hikeshi-a-nuclear-transporter-for-heat-shock-protein-hsp70-causes-infantile-hypomyelinating-leukoencephalopathy
#12
Catalina Vasilescu, Pirjo Isohanni, Maarit Palomäki, Helena Pihko, Anu Suomalainen, Christopher J Carroll
Genetic leukoencephalopathies are a heterogeneous group of central nervous system disorders with white matter involvement. In a Finnish patient, we identified a novel homozygous disease-causing variant in HIKESHI, c.11G>C, p.(Cys4Ser), leading to hypomyelinating leukoencephalopathy with periventricular cysts and vermian atrophy. A founder Ashkenazi-Jewish disease-causing variant recently linked Hikeshi and its heat-shock protective function to leukoencephalopathy. In our patient, clinical features of lower limb spasticity, optic atrophy, nystagmus, and severe developmental delay were similar to reported patients...
December 21, 2016: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28000495/postal-censorship-of-bosnian-public-health-institutions-during-the-second-world-war-the-independent-state-of-croatia-versus-dr-stanko-sielski
#13
John A Papalas, Husref Tahirović
: This study aims to present evidence of censorship during World War II by the Independent State of Croatia of one of its public health officials, Dr. Stanko Sielski who was a physician trained in epidemiology and public health. During World War II, he directed the Institute for Combating Endemic Syphilis in the Bosnian town Banja Luka. The staff under his direction consisted solely of Jewish physicians. We analyzed two groups of envelopes either sent by or to Dr. Stanko Sielski during the War and found evidence of censorship only in communications with a Jewish physician dated towards the end of the War...
November 2016: Acta Medica Academica
https://www.readbyqxmd.com/read/27995442/religion-alcohol-use-and-risk-drinking-among-canadian-adults-living-in-ontario
#14
Andrew Tuck, Margaret Robinson, Branka Agic, Anca R Ialomiteanu, Robert E Mann
This research examines (1) the association between risk drinking and religious affiliation and (2) differences between religions for risk drinking among adults living in Ontario, Canada, for Christians, Buddhists, Sikhs, Muslims, Hindus, Jews, other religious groups and the non-religious. Data are based on telephone interviews with 16,596 respondents and are derived from multiple cycles (2005-2011) of the Centre for Addiction and Mental Health's (CAMH) Monitor survey, an ongoing cross-sectional survey of adults in Ontario, Canada, aged 18 years and older...
December 19, 2016: Journal of Religion and Health
https://www.readbyqxmd.com/read/27968937/the-fate-of-hungarian-jewish-dermatologists-during-the-holocaust-part-2-under-nazi-rule
#15
Julia Bock, Walter H C Burgdorf, Leonard J Hoenig, Lawrence Charles Parish
At least 564,500 Hungarian Jews perished during the Holocaust, including many physicians. Exactly how many Jewish dermatologists were killed is not known. We have identified 62 Hungarian Jewish dermatologists from this period: 19 of these dermatologists died in concentration camps or were shot in Hungary, 3 committed suicide, and 1 died shortly after the Holocaust, exhausted by the War. Fortunately, many Hungarian Jewish dermatologists survived the Holocaust. Some had fled Europe before the Nazi takeover, as was described in Part 1 of this contribution...
November 2016: Clinics in Dermatology
https://www.readbyqxmd.com/read/27966799/infant-attachment-and-maternal-sensitivity-in-the-arab-minority-in-israel
#16
Ghadir Zreik, David Oppenheim, Abraham Sagi-Schwartz
This study is the first to examine infant-mother attachment in the Arab culture. Eighty-five Arab 1-year-old infants from Israel were observed in the strange situation, and maternal sensitivity was assessed from home observations. Supporting attachment theory's normativity hypothesis, no differences were found between the Arab-Israeli attachment distribution and Jewish-Israeli, Western, and non-Western distributions when examined at the two-way secure versus insecure level, although a few differences emerged when examined at the four-way ABCD level...
December 14, 2016: Child Development
https://www.readbyqxmd.com/read/27957321/social-characteristics-associated-with-disparities-in-smoking-rates-in-israel
#17
Ofra Kalter-Leibovici, Angela Chetrit, Shlomit Avni, Emma Averbuch, Ilya Novikov, Nihaya Daoud
BACKGROUND: Cigarette smoking is a major cause of health disparities. We aimed to determine social characteristics associated with smoking status and age at smoking initiation in the ethnically-diverse population of Israel. METHODS: This is a cross-sectional survey, based on data collected during 2010 by the Israel Bureau of Statistics, in a representative nationwide sample of 7,524 adults (≥20 years). Information collected by personal interviews included a broad set of demographic and socio-economic characteristics and detailed information on smoking habits...
2016: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/27936475/-jewish-participants-and-contributions-to-the-conferences-of-the-german-ophthalmological-society-during-national-socialism
#18
J M Rohrbach
No abstract text is available yet for this article.
December 9, 2016: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/27933661/mutations-in-the-neb-gene-cause-fetal-akinesia-arthrogryposis-multiplex-congenita
#19
Michal Feingold-Zadok, David Chitayat, Karen Chong, Marie Injeyan, Patrick Shannon, Daphne Chapmann, Ron Maymon, Nir Pillar, Orit Reish
OBJECTIVE: We studied a series of patients with fetal akinesia deformation sequence (FADS)/arthrogryposis multiplex congenita (AMC), with nemaline bodies on muscle specimens, that revealed mutations in the NEB gene. METHOD: We pathologically assessed seven cases from three families, who presented with AMC/FADS. Targeted genetic analysis for Ashkenazi Jewish (AJ) mutation (in relevant patients) was followed by next generation sequencing and Multiplex Ligation-dependent Probe Amplification...
December 9, 2016: Prenatal Diagnosis
https://www.readbyqxmd.com/read/27927727/why-do-holocaust-survivors-remember-what-they-remember
#20
Sarah L Canham, Hagit Peres, Norm O'Rourke, David B King, Annette Wertman, Sara Carmel, Yaacov G Bachner
PURPOSE OF THE STUDY: The ability to integrate traumatic memories into a coherent life narrative is one factor associated with the mental health and well-being of Holocaust survivors. In the present study, reminiscences reported by survivors in Israel were collected to identify themes arising in positive and negative memories and experience. DESIGN AND METHODS: Participants (M = 80.4 years; SD = 6.87) were asked to describe memories that typify a reminiscence function in which they frequently or very frequently engage...
December 7, 2016: Gerontologist
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