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https://www.readbyqxmd.com/read/29158058/regional-cerebral-oxygen-saturation-level-predicts-30-day-mortality-rate-after-left-ventricular-assist-device-surgery
#1
Soutik Ghosal, Jaimin Trivedi, James Chen, Michael P Rogers, Allen Cheng, Mark S Slaughter, Maiying Kong, Jiapeng Huang
OBJECTIVE: Left ventricular assist device (LVAD) surgery is complex, high risk, and expensive. The authors' hypothesis is baseline regional cerebral oxygen saturation (rSO2) might be a predictor of postoperative clinical outcomes. DESIGN: Retrospective review of 210 consecutive continuous flow LVAD patients between 2008 and 2014. The primary measure is 30-day mortality rate and secondary measures include modified major adverse cardiocerebral events (MACE), length of stay (LOS), and intensive care unit (ICU) stay...
August 19, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29157640/early-to-bed-early-to-rise-sleep-perceptions-patterns-and-related-behaviors-in-ultra-orthodox-jewish-adolescents-in-israel
#2
Hila Vidal, Tamar Shochat
OBJECTIVES: Studies have described biological and environmental mechanisms underlying adolescent sleep, yet the role of culture has received little attention. Ultra-orthodox (Haredi) Judaism adheres to a traditional lifestyle. To examine how culture and lifestyle are associated with sleep, this study compared sleep perceptions, habits, and patterns and related daytime behaviors among ultra-orthodox and secular Jewish adolescents. METHODS: A sample of 178 healthy adolescents (116 ultra-orthodox, 77 males, ages 13-17) gathered via snowball sampling completed the School Sleep Habits Survey to assess sleep perceptions, habits, patterns (timing and duration), and related behaviors (sleepiness, mood, sleep-problem behaviors)...
December 2017: Sleep Health
https://www.readbyqxmd.com/read/29153277/a-novel-rogdi-gene-mutation-is-associated-with-kohlschutter-tonz-syndrome
#3
Nalini Aswath, Sankar Narayanan Ramakrishnan, Nithya Teresa, Arvind Ramanathan
OBJECTIVE: Kohlschutter-tonz syndrome (KTS) is a rare neurodegenerative disorder that presents with seizures, developmental regression, characteristic hypoplastic dental enamel indicative of amelogenesis imperfecta and dysmorphologies. Genetic analysis has identified loss-of-function mutations within the coding region of the ROGDI gene in KTS patients of European or Jewish decent. In the present study, we have investigated the genetic status of ROGDI in a fourteen year old South Indian patient of Dravidian race born to consanguineous parents, who was clinically diagnosed with KTS STUDY DESIGN: To confirm the clinical diagnosis of KTS in the patient, primers were designed flanking each of the 11 exons of the ROGDI gene...
October 12, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29144848/watching-the-evolution-of-the-american-family-amazon-s-transparent-ecological-systems-theory-and-the-changing-dynamics-of-public-opinion
#4
Amy B Becker, Maureen E Todd
Using Bronfenbrenner's (1979) ecological systems theory as an organizing framework, the research closely examines the text of the Amazon Studios hit show, Transparent, and by extension the evolution of public opinion towards transgender individuals. By examining the Pfefferman family in detail and their related microsystem and macrosystem, we are able to closely unpack the transition of Jeffrey Tambor's character from Mort to Maura and the show's connections with broader developments in the Los Angeles LGBT community and the Jewish diaspora in postwar and contemporary Los Angeles...
November 16, 2017: Journal of Homosexuality
https://www.readbyqxmd.com/read/29144512/ashkenazi-jewish-genomic-variants-integrating-data-from-the-israeli-national-genetic-database-and-gnomad
#5
Joël Zlotogora, George P Patrinos, Vardiella Meiner
PurposeThe aim of the study was to compare the data for mutations related to clinical disorders reported among Ashkenazi Jewish patients in the Israeli National Genetic Database (INGD) with variants included in the Genome Aggregation Database (gnomAD).MethodsWe extracted data for mutations claimed to cause disorders reported among Ashkenazi Jews from the INGD and searched gnomAD for each of them. We compared the allele frequency of each variant in Ashkenazi Jews with that of other delineated populations.ResultsOf the 58 INGD-reported mutations related to autosomal-dominant disorders, 19 were present in gnomAD (32...
November 16, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29135419/the-risk-of-cancer-might-be-lower-than-we-think-alternatives-to-lifetime-risk-estimates
#6
Gilat L Grunau, Shay Gueron, Boris Pornov, Shai Linn
BACKGROUND: Estimates of lifetime cancer risk are commonly used in the clinical setting and in health-care evaluations. These measures are based on lifetime cancer risk estimates and may create an unrealistically frightening perception of cancer risk for an individual. We suggest using two new measures of cancer risk to complement the cancer lifetime risk measure, namely estimates of cancer risk from birth to a specific age or from a specific age to life expectancy. METHODS: We calculated risks using incidence density data from the Israel National Cancer Registry of 2013, applying a well-known formula for calculating risk, for a follow-up time...
October 16, 2017: Rambam Maimonides Medical Journal
https://www.readbyqxmd.com/read/29129955/a-comparative-analysis-of-bioethical-issues-from-view-points-of-religious-affairs-administration-in-turkey-roman-catholicism-and-orthodox-judaism
#7
Cemal Huseyin Güvercin, Kerim M Munir
The arguments set forth by religious authority are important since they play a crucial role in shaping the social values of the public and influence the decision of individuals in practice pertaining to bioethical issues. The Religious Affairs Administration (RAA) was established at the inception of the Republic of Turkey in 1924 to guide religious considerations moving out of the Ottoman caliphate to a secular bioethical framework. In this article, the bioethical views of the RAA under Islamic tradition is examined and contrasted with those influenced by the Roman Catholic and Orthodox Judaic traditions...
July 2017: Acta Bioethica
https://www.readbyqxmd.com/read/29126459/emergency-department-waiting-times-in-a-tertiary-children-s-hospital-in-israel-a-retrospective-cohort-study
#8
Oren Feldman, Raviv Allon, Ronit Leiba, Itai Shavit
BACKGROUND: The purpose of this study was to assess ethnic differences in Emergency Department (ED) waiting times between Jewish and Arab children in a tertiary childrens' hospital in Israel. METHODS: This was a retrospective cohort study of all children who were admitted to the pediatric ED of the largest hospital in northern Israel, between January 2011 and December 2015. Univariate and multivariate analyses were used to assess the strength of association between ethnicity category and waiting time...
November 10, 2017: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/29125806/the-secret-of-intrafamilial-child-sexual-abuse-who-keeps-it-and-how
#9
Dafna Tener
This article analyzes how women survivors of intrafamilial child sexual abuse perceive the family members who took part in keeping it secret and their tactics for doing so. Analysis of 20 in-depth interviews with Jewish Israeli women revealed unique ways of guarding the secret. These were attributed to the perpetrator, the mother and the family. Secret-keeping tactics included presenting a normative public identity or an unstable psychological identity, presenting multiple personas, reframing the abuse, concealing any trace of the secret after it was disclosed, as if the abuse had never happened, and making a monument of the abuser...
November 10, 2017: Journal of Child Sexual Abuse
https://www.readbyqxmd.com/read/29109168/risk-factors-and-outcomes-for-ineffective-empiric-treatment-in-gram-negative-sepsis-stratification-by-onset-of-infection
#10
Scott T Micek, Nicholas Hampton, Marin Kollef
Sepsis and septic shock remain serious infections with reported mortality rates in excess of forty percent. Timely antibiotic therapy in sepsis and septic shock is recognized as an important determinant of outcome. However, the administration of ineffective empiric treatment (IET) (an initial antibiotic regimen that is not active against the identified pathogen(s) based on in vitro susceptibility testing) is associated with excess mortality compared to effective empiric treatment (EET). We examined all hospitalized patients between January 2010 and October 2015 at Barnes-Jewish Hospital with the presence of a sterile site (blood, or pleural, abdominal, cerebrospinal, synovial, and pericardial fluid) culture positive for Gram-negative (GN) bacteria combined with primary or secondary ICD-9-CM codes for severe sepsis (995...
November 6, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29108425/bipolar-disorder-associated-with-another-autoimmune-disease-pemphigus-a-population-based-study
#11
Khalaf Kridin, Shira Zelber-Sagi, Doron Comaneshter, Arnon D Cohen
OBJECTIVES: Recent evidence suggests a notable role for inflammation and immune dysregulation in the neuroprogression of bipolar disorders (BD). Several autoimmune comorbidities have been reported in association with BD. However, the epidemiological relationship between pemphigus and BD has not yet been elucidated. We aimed to estimate the association between pemphigus and BD using a large-scale, real-life computerized database. METHODS: Data for this study were retrieved from the database of the Clalit Health Services, the largest, state-mandated, health service organization in Israel...
January 1, 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/29104185/saving-the-philosopher-s-soul-the-i-de-pietate-aristotelis-i-by-fortunio-liceti
#12
Eva Del Soldato
The De pietate Aristotelis erga Deum et homines (1645) by Fortunio Liceti is a one-of-a-kind text. In this book Liceti claimed that Aristotle converted to Judaism, and that he never contradicted the Scriptures in his writings. At a time when competing philosophical and scientific schools put Aristotle at odds with faith, restoring his reputation from a religious point of view could be seen as key to safeguarding Peripateticism. Nonetheless Liceti composed his work not to polemicize with anti-Aristotelians, but rather with fellow Aristotelians who were not sufficiently committed to defending his stature...
2017: Journal of the History of Ideas
https://www.readbyqxmd.com/read/29097670/the-genetic-variation-in-the-r1a-clade-among-the-ashkenazi-levites-y-chromosome
#13
Doron M Behar, Lauri Saag, Monika Karmin, Meir G Gover, Jeffrey D Wexler, Luisa Fernanda Sanchez, Elliott Greenspan, Alena Kushniarevich, Oleg Davydenko, Hovhannes Sahakyan, Levon Yepiskoposyan, Alessio Boattini, Stefania Sarno, Luca Pagani, Shai Carmi, Shay Tzur, Ene Metspalu, Concetta Bormans, Karl Skorecki, Mait Metspalu, Siiri Rootsi, Richard Villems
Approximately 300,000 men around the globe self-identify as Ashkenazi Levites, of whom two thirds were previously shown to descend from a single male. The paucity of whole Y-chromosome sequences precluded conclusive identification of this ancestor's age, geographic origin and migration patterns. Here, we report the variation of 486 Y-chromosomes within the Ashkenazi and non-Ashkenazi Levite R1a clade, other Ashkenazi Jewish paternal lineages, as well as non-Levite Jewish and non-Jewish R1a samples. Cumulatively, the emerging profile is of a Middle Eastern ancestor, self-affiliating as Levite, and carrying the highly resolved R1a-Y2619 lineage, which was likely a minor haplogroup among the Hebrews...
November 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29091079/nox1-loss-of-function-genetic-variants-in-patients-with-inflammatory-bowel-disease
#14
T Schwerd, R V Bryant, S Pandey, M Capitani, L Meran, J-B Cazier, J Jung, K Mondal, M Parkes, C G Mathew, K Fiedler, D J McCarthy, P B Sullivan, A Rodrigues, S P L Travis, C Moore, J Sambrook, W H Ouwehand, D J Roberts, J Danesh, R K Russell, D C Wilson, J R Kelsen, R Cornall, L A Denson, S Kugathasan, U G Knaus, E G Serra, C A Anderson, R H Duerr, D Pb McGovern, J Cho, F Powrie, V Sw Li, A M Muise, H H Uhlig
Genetic defects that affect intestinal epithelial barrier function can present with very early-onset inflammatory bowel disease (VEOIBD). Using whole-genome sequencing, a novel hemizygous defect in NOX1 encoding NAPDH oxidase 1 was identified in a patient with ulcerative colitis-like VEOIBD. Exome screening of 1,878 pediatric patients identified further seven male inflammatory bowel disease (IBD) patients with rare NOX1 mutations. Loss-of-function was validated in p.N122H and p.T497A, and to a lesser degree in p...
November 1, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/29090476/demographics-and-patient-characteristics-of-1209-patients-with-gaucher-disease-descriptive-analysis-from-the-gaucher-outcome-survey-gos
#15
Ari Zimran, Nadia Belmatoug, Bruno Bembi, Patrick Deegan, Deborah Elstein, Diego Fernandez-Sasso, Pilar Giraldo, Ozlem Goker-Alpan, Heather Lau, Elena Lukina, Zoya Panahloo, Ida Vanessa D Schwartz
The Gaucher Outcome Survey (GOS) is an international Gaucher disease (GD) registry established in 2010 for patients with a confirmed GD diagnosis, regardless of GD type or treatment status, designed to evaluate the safety and long-term effectiveness of velaglucerase alfa and other GD-related treatments. As of February 25, 2017, 1209 patients had enrolled, the majority from Israel (44.3%) and the US (31.4%). Median age at GOS entry was 40.4 years, 44.1% were male, and 13.3% had undergone a total splenectomy...
November 1, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/29080319/performance-of-risk-stratification-criteria-in-the-management-of-febrile-young-infants-younger-than-three-months-of-age
#16
Yekaterina Belov, Eugene Leibovitz, Alina Vodonos, Guy Hazan, Eduard Ling, Rimma Melamed
AIM: We evaluated the diagnosis, risk stratification and management of febrile infants under three months of age who presented to an Israeli pediatric emergency room (ER). METHODS: This retrospective study enrolled all febrile infants examined in the pediatric ER of Soroka Medical Center during 2010-2013. The patients were classified into low-risk and high-risk subgroups and compared by age and ethnicity. RESULTS: Overall, 2,251 febrile infants (60...
October 28, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29073821/widowhood-in-the-israeli-arab-muslim-society
#17
Hend Yasien-Esmael, Simon Shimshon Rubin, Yohanan Eshel
Adjustment of Israeli Arab Muslim widows to the traumatic loss of their husbands was examined by comparing their reported ways of coping with those of married women of their community by means of the Two-Track-Bereavement Model. Participants included 93 widows and 86 comparable married women who were mostly middle aged and of middle class. We hypothesized that widows will express concurrently greater suffering and higher resilience to adverse life events compared with married women. It was hypothesized further that positive and close relations to a deceased husband will be reported by Arab widows as well as Arab married women...
January 1, 2017: Omega
https://www.readbyqxmd.com/read/29072380/-comparison-of-clinical-and-demographic-characteristics-of-arab-and-jewish-children-living-in-the-galilee-who-have-suffered-from-an-intestinal-infection-caused-by-campylobacter
#18
Ali Arian, Said Abozaid, Avi On, Wael Nasser, Nina Pastukh, Avi Peretz
INTRODUCTION: Among all infectious agents that cause gastrointestinal infection in children, the most common is the Campylobacter bacterium. The bacterium has multiple virulence factors such as motility, adhesion and invasion of the human intestinal lining, and enzyme secretion. In recent years, there has been a worldwide increase in Campylobacter resistance to antibiotics. AIMS: To examine the frequency of Campylobacter among children who were hospitalized at the Poriya Medical Center during 2012-2014 and suffered from an intestinal infection caused by Campylobacter; to compare the demographic, clinical, and laboratory data of Jewish and Arab children; to examine the resistance rate of the bacterium to antibiotics...
October 2017: Harefuah
https://www.readbyqxmd.com/read/29069506/-irish-roman-catholic-which-upsets-all-the-people-here-michael-mcdonnell-and-british-colonial-justice-in-mandatory-palestine-1927-1936
#19
Simon Davis
In 1927 Michael McDonnell, a diasporic Irish Catholic, was appointed Mandatory Palestine's Chief Justice, being directed to institute firm British-style legal-judicial foundations for future self-governance. This entailed common, equal status for Arab and Jewish Palestinians, implicitly de-privileging the Jewish National Home. McDonnell was resisted in this by the British Mandate's Anglo-Jewish, pro-Zionist Attorney General, Norman Bentwich. McDonnell prevailed but only at the cost of being characterized lastingly as a pro-Arab, Catholic anti-Semite...
October 23, 2017: 20 Century British History
https://www.readbyqxmd.com/read/29066037/end-of-life-care-preferences-in-patients-with-severe-and-persistent-mental-illness-and-chronic-medical-conditions-a-comparative-cross-sectional-study
#20
Dominique Elie, Amanda Marino, Susana G Torres-Platas, Saeid Noohi, Trent Semeniuk, Marilyn Segal, Karl J Looper, Soham Rej
OBJECTIVES: Physicians rarely engage severe and persistent mental illness (SPMI) patients in end-of-life care discussion despite an increased risk of debilitating medical illnesses and mortality. Access to quality palliative care and medical assistance in dying (MAID) has become a priority in Canada and many jurisdictions. In this study, we compared SPMI and chronic medically ill (CMI) patients' end-of-life care preferences and comfort level with end-of-life care discussion, and identified potential predictors of interest in MAID...
September 25, 2017: American Journal of Geriatric Psychiatry
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