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https://www.readbyqxmd.com/read/26452331/hematopoietic-stem-cell-transplantation-in-the-eastern-mediterranean-region-emro-2011-2012-a-comprehensive-report-on-behalf-of-the-eastern-mediterranean-blood-and-marrow-transplantation-group-embmt
#1
Mahmoud Aljurf, Amr Nassar, Amir Ali Hamidieh, Alaa Elhaddad, Rose-Marie Hamladji, Ali Bazarbachi, Ahmed Ibrahim, Tarek Ben Othman, Fawzi Abdel-Rahman, Amal Alseraihy, Omar Fahmy, Ayad Ahmed Hussein, Abdulaziz Alabdulaaly, Salman Adil, Salam Salim Amur Alkindi, Mohamed Bayoumy, David Dennison, Mohamed Amine Bekadja, Ahmed Nacer Redhouane, Walid Rasheed, Ahmed AlSagheir, Reem Alsudairy, Saloua Ladeb, Said Benchekroun, Mani Ramzi, Parvez Ahmed, Hassan ElSolh, Syed Osman Ahmed, Fazal Hussain, Ardeshir Ghavamzadeh
OBJECTIVE/BACKGROUND: The Eastern Mediterranean Blood and Marrow Transplantation (EMBMT) group has accumulated over 31 years of data and experience in hematopoietic stem cell transplantation (HSCT), particularly in hemoglobinopathies, severe aplastic anemia, inherited metabolic and immune disorders, in addition to a wide array of hematologic malignancies unique to this region. A regional update in current HSCT trends is highly warranted. We studied the trends of HSCT activities in World Health Organization-Eastern Mediterranean (EMRO) region, surveyed by the EMBMT, between 2011 and 2012...
December 2015: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/26417807/mental-state-and-its-psychophysical-conditions-in-patients-with-acute-leukaemia-treated-with-bone-marrow-transplantation
#2
Anna Warchala, Ewa Wojtyna, Krzysztof Krysta
BACKGROUND: Acute leukaemia and bone marrow transplantation (BMT) as a method of its treatment are great psychological stressors, which are responsible for anxiety and depression in the group of patients. The aim of the study was to assess the patients' mental state and its psychophysical predictors before and after BMT. SUBJECT AND METHOD: The study was of a longitudinal and self-descriptive character. The questionnaires: LOT-R, AIS, Mini-Mac, CECS, RSCL and HADS were filled by 60 patients with acute leukaemia before and after BMT...
September 2015: Psychiatria Danubina
https://www.readbyqxmd.com/read/25445636/blood-and-marrow-transplant-clinical-trials-network-state-of-the-science-symposium-2014
#3
Frederick R Appelbaum, Claudio Anasetti, Joseph H Antin, Harold Atkins, Stella Davies, Steven Devine, Sergio Giralt, Helen Heslop, Ginna Laport, Stephanie J Lee, Brent Logan, Marcelo Pasquini, Michael Pulsipher, Edward Stadtmauer, John R Wingard, Mary M Horowitz
No abstract text is available yet for this article.
February 2015: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/25380941/biosimilar-granulocyte-colony-stimulating-factor-is-effective-in-reducing-the-duration-of-neutropenia-after-autologous-peripheral-blood-stem-cell-transplantation
#4
M Cioch, D Jawniak, K Kotwica, M Wach, J Mańko, A Gorący, P Klimek, E Mazurkiewicz, P Jarosz, M Hus
BACKGROUND: Autologous peripheral blood stem cell transplantation (APBSCT) is the standard of therapy for patients with multiple myeloma and refractory Hodgkin's and non-Hodgkin's lymphomas. Granulocyte colony-stimulating factor (G-CSF) is widely used to accelerate hematopoietic recovery after transplantation and to reduce the morbidity and mortality associated with prolonged neutropenia. Biosimilar G-CSF is approved for the same indications as the originator G-CSF. This is one of the first reported uses of a biosimilar G-CSF for neutrophil recovery after APBSCT...
October 2014: Transplantation Proceedings
https://www.readbyqxmd.com/read/25018062/thrombosis-and-hemostatic-abnormalities-in-hematological-malignancies
#5
REVIEW
Riccardo Colombo, Paolo Gallipoli, Roberto Castelli
There is a paucity of data that pertain to thrombosis in patients with hematological malignancies. Recent studies showed that patients with lymphoma, multiple myeloma, and acute leukemia have an increased thrombotic risk, particularly at the time of diagnosis and during chemotherapy. We searched the PubMed database for articles on thromboembolic complications in patients with hematological malignancies published between 1996 and 2013. The incidence of thrombotic events is variable, and is influenced by the type and the stage of hematological malignancy, the antitumor therapy, and the use of central venous devices...
December 2014: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/24680978/polymorphism-of-cd44-influences-the-efficacy-of-cd34-cells-mobilization-in-patients-with-hematological-malignancies
#6
Anna Szmigielska-Kaplon, Janusz Szemraj, Katarzyna Hamara, Marta Robak, Anna Wolska, Agnieszka Pluta, Magdalena Czemerska, Anna Krawczynska, Krzysztof Jamroziak, Katarzyna Szmigielska, Tadeusz Robak, Agnieszka Wierzbowska
In the last decade, peripheral blood was the main source of hematopoietic stem cells (HSC) for autologous and allogeneic transplantation. The exact mechanisms of HSC mobilization are still not clear and the efficacy of the procedure is hardly predictable. Ligand-receptor interactions of adhesion molecules, such as SDF1/CXCR4, VLA4/VCAM-1, or CD44/osteopontin, play an important role in homing of HSC in the hematopoietic niche. There is some evidence that disruption of the ligand-receptor complex leads to the egress of HSCs to the peripheral blood...
July 2014: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/24404922/patient-stories-an-innovative-direction-for-nurses-providing-support-to-hematology-patients-in-rural-areas
#7
Pam McGrath, Hamish Holewa
AIMS: This study set out to explore the attitudes toward a "Patient Stories" DVD as a psychosocial support initiative for patients diagnosed with a hematological malignancy. DESIGN: A qualitative research design was employed through a series of open-ended interviews and one focus group. PARTICIPANTS: Participants were purposively sampled from a database of patients maintained by the Leukaemia Foundation of Queensland. In total, there were 50 participants (n=26 male, n=24 female), which represented the following major hematological diagnostic groups: multiple myeloma (n=15), lymphoma (n=14), leukemia (n=17), and other (n=4)...
July 2014: Nursing Forum
https://www.readbyqxmd.com/read/24320421/interplay-effects-between-dose-distribution-quality-and-positioning-accuracy-in-total-marrow-irradiation-with-volumetric-modulated-arc-therapy
#8
Pietro Mancosu, Piera Navarria, Luca Castagna, Giacomo Reggiori, Barbara Sarina, Stefano Tomatis, Filippo Alongi, Giorgia Nicolini, Antonella Fogliata, Luca Cozzi, Marta Scorsetti
PURPOSE: To evaluate the dosimetric consequences of inaccurate isocenter positioning during treatment of total marrow (lymph-node) irradiation (TMI-TMLI) using volumetric modulated arc therapy (VMAT). METHODS: Four patients treated with TMI and TMLI were randomly selected from the internal database. Plans were optimized with VMAT technique. Planning target volume (PTV) included all the body bones; for TMLI, lymph nodes and spleen were considered into the target, too...
November 2013: Medical Physics
https://www.readbyqxmd.com/read/24138174/how-beneficial-is-the-use-of-nsaids-in-stem-cell-transplantation
#9
EDITORIAL
Jonathan Hoggatt, Louis M Pelus
For a number of malignant hematologic diseases, including leukemias, lymphomas and myelomas, hematopoietic stem cell transplantation remains the only curative option. The stem cell sources for these life-saving transplants come from bone marrow, umbilical cord blood, or from the peripheral blood of patients or donors treated with mobilizing agents. Recently, the use of nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin, ibuprofen and meloxicam has been reported to enhance the ability to acquire stem cells from mobilized peripheral blood, resulting in a superior stem cell graft...
December 2013: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/23988403/individual-quality-assessment-of-autografting-by-probability-estimation-for-clinical-endpoints-a-prospective-validation-study-from-the-european-group-for-blood-and-marrow-transplantation
#10
REVIEW
Francesco Lanza, Diana C Campioni, Andrzej Hellmann, Giuseppe Milone, Anders Wahlin, Jan Walewski, Pierangelo Spedini, Cristina Fiamenghi, Antonio Cuneo, Wanda Knopińska, Monica Swierkowska-Czeneszew, Jordi Petriz, Stefan Fruehauf, Dominique Farge, Mohamad Mohty, Jacob Passweg, Tapani Ruuto, Alejandro Madrigal, Hans E Johnsen
The aim of supportive autografting is to reduce the side effects from stem cell transplantation and avoid procedure-related health disadvantages for patients at the lowest possible cost and resource expenditure. Economic evaluation of health care is becoming increasingly important. We report clinical and laboratory data collected from 397 consecutive adult patients (173 non-Hodgkin lymphoma, 30 Hodgkin lymphoma, 160 multiple myeloma, 7 autoimmune diseases, and 28 acute leukemia) who underwent their first autologous peripheral blood stem cell transplantation (PBSCT)...
December 2013: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/23782085/oxidative-stress-in-oncohematologic-diseases-an-update
#11
Selene Imbesi, Caterina Musolino, Alessandro Allegra, Antonella Saija, Fortunato Morabito, Gioacchino Calapai, Sebastiano Gangemi
An increased risk of cancer in various organs has been related to oxidative stress and several studies have revealed the mechanism by which continued oxidative stress can lead to chronic inflammation, which in turn could mediate most chronic diseases including cancer. A variety of transcription factors may be activated in consequence of oxidative stress, leading to the expression of over 500 different genes, including those for growth factors, inflammatory cytokines, chemokines, cell cycle regulatory molecules and anti-inflammatory molecules...
June 2013: Expert Review of Hematology
https://www.readbyqxmd.com/read/23580820/stem-cell-transplant-an-experience-from-eastern-india
#12
A Mukhopadhyay, P Gupta, J Basak, A Chakraborty, D Bhattacharyya, S Mukhopadhyay, U K Roy
BACKGROUND: Hematopoietic stem cell transplant using human leukocyte antigen (HLA)-matched sibling or unrelated bone marrow, or related or unrelated cord blood has been performed successfully to treat patients with different types of hematological malignancies, genetic disorders and hereditary immune deficiencies. Since 1983, stem cell transplantation has been carried out in different institutes of India. But, till then, no transplantation was performed in eastern India. MATERIALS AND METHODS: Our present study is reporting for the first time stem cell transplantation in eastern India...
October 2012: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/23153925/immunomodulatory-drugs-new-options-for-the-treatment-of-myelodysplastic-syndromes
#13
REVIEW
Roberto Castelli, Ramona Cassin, Antonino Cannavò, Massimo Cugno
BACKGROUND: Myelodysplastic syndromes (MDS) are common adult hematologic disorders characterized by ineffective hematopoiesis with progressive cytopenia and a risk of evolving into currently incurable acute myeloid leukemia. Until recently, the only treatment was bone marrow transplantation, but, over the past few years, a new therapeutic approach based on immunomodulatory drugs (IMiD) has been developed. IMiDs belong to a therapeutic class whose progenitor is thalidomide, a synthetic derivative of glutamate that was initially used because of its sedative and antiemetic properties but was then withdrawn because of its teratogenic effects...
February 2013: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/23022262/return-to-primary-service-among-bone-marrow-transplant-rehabilitation-inpatients-an-index-for-predicting-outcomes
#14
Jack B Fu, Jay Lee, Dennis W Smith, Ying Guo, Eduardo Bruera
OBJECTIVE: To assess rehabilitation inpatient risk of return to primary (RTP) service in patients with bone marrow transplant (BMT). DESIGN: Retrospective review. SETTING: Inpatient rehabilitation unit within a tertiary referral-based cancer center. PARTICIPANTS: All patients with BMT (131) who were admitted a total of 147 times to inpatient rehabilitation between January 1, 2002, and April 30, 2010. INTERVENTIONS: None...
February 2013: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/22862907/neutropenic-enterocolitis-after-high-dose-chemotherapy-and-autologous-stem-cell-transplantation-incidence-risk-factors-and-outcome
#15
L Gil, D Poplawski, A Mol, A Nowicki, A Schneider, M Komarnicki
BACKGROUND: Neutropenic enterocolitis (NE) is a life-threatening complication occurring after intensive chemotherapy; however, no data are available on NE development after hematopoietic stem cell transplantation (SCT). The aim of this study was to determine the incidence, risk factors, and outcome of NE after high-dose chemotherapy and autologous SCT (autoSCT). METHODS: A total of 297 adult patients who qualified for autoSCT with non-Hodgkin's lymphoma (NHL), Hodgkin's disease, multiple myeloma, and acute myeloid leukemia were analyzed...
February 2013: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/22796533/alloreactive-effector-t-cells-require-the-local-formation-of-a-proinflammatory-environment-to-allow-crosstalk-and-high-avidity-interaction-with-nonhematopoietic-tissues-to-induce-gvhd-reactivity
#16
Boris van der Zouwen, Alwine B Kruisselbrink, Ekaterina S Jordanova, Caroline E Rutten, Peter A von dem Borne, J H Frederik Falkenburg, Inge Jedema
Based on clinical observations that donor T cells specific for minor histocompatibility antigens (MiHA) ubiquitously expressed on both hematopoietic and nonhematopoietic cells were detected in patients showing evident graft-versus-leukemia/lymphoma (GVL) reactivity with no or limited coinciding graft-versus-host disease (GVHD), we hypothesized that nonhematopoietic tissues may be relatively unsusceptible to the cytotoxic effect of MiHA-specific T cells under normal, noninflammatory conditions. To test this hypothesis, we investigated the reactivity of alloreactive T cells specific for ubiquitously expressed MiHA against skin-derived primary human fibroblasts...
September 2012: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/22624029/cks1-is-required-for-tumor-cell-proliferation-but-not-sufficient-to-induce-hematopoietic-malignancies
#17
Susanne Kratzat, Viktoriya Nikolova, Cornelius Miething, Alexander Hoellein, Stephanie Schoeffmann, Oliver Gorka, Elke Pietschmann, Anna-Lena Illert, Jürgen Ruland, Christian Peschel, Jonas Nilsson, Justus Duyster, Ulrich Keller
The Cks1 component of the SCF(Skp2) complex is necessary for p27(Kip1) ubiquitylation and degradation. Cks1 expression is elevated in various B cell malignancies including Burkitt lymphoma and multiple myeloma. We have previously shown that loss of Cks1 results in elevated p27(Kip1) levels and delayed tumor development in a mouse model of Myc-induced B cell lymphoma. Surprisingly, loss of Skp2 in the same mouse model also resulted in elevated p27(Kip1) levels but exhibited no impact on tumor onset. This raises the possibility that Cks1 could have other oncogenic activities than suppressing p27(Kip1)...
2012: PloS One
https://www.readbyqxmd.com/read/22450582/-b-cell-acute-lymphoblastic-leukemia-developed-5-years-after-autologous-stem-cell-transplantation-for-multiple-myeloma
#18
Yuiko Tsukada, Yutaka Hattori, Hideaki Nakajima, Kenji Yokoyama, Mitsuru Murata, Nobuko Shimizu, Naomi Kondo, Shinichiro Okamoto
A 61-year-old female was diagnosed with multiple myeloma (MM) in 2001. After treatment with chemotherapy containing alkylating agents and thalidomide, she underwent autologous stem cell transplantation in 2003, with high-dose melphalan as a conditioning regimen. Thalidomide was also given after the transplant from July 2003 to November 2005 for residual disease and she remained in partial remission. In October 2008, she developed pancytopenia. Bone marrow examination confirmed the diagnosis of acute B lymphoblastic leukemia (B-ALL)...
February 2012: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/22356598/psychosocial-predictors-of-immune-response-following-bone-marrow-transplantation
#19
Ángeles Pulgar, Sergio Garrido, Antonio Alcalá, Gustavo A Reyes del Paso
This study analyzed the relationship between some psychosocial variables (depression, anxiety, stress, coping strategies, social support, optimism, rationality, and need for harmony) and clinical parameters indicative of immunological response after bone marrow transplantation (BMT; day of engraftment, number of infections and hemoglobin level) while controlling for demographic variables (age, educative level, civil state, and time from cancer diagnosis). Thirty-one post BMT hematological cancer patients were evaluated...
January 2012: Behavioral Medicine
https://www.readbyqxmd.com/read/22352263/impact-of-stem-cell-source-on-allogeneic-stem-cell-transplantation-outcome-in-hematological-malignancies
#20
COMPARATIVE STUDY
Dragana Stamatović, Bela Balint, Ljiljana Tukić, Marija Elez, Olivera Tarabar, Milena Todorović, Gordana Ostojić, Zeljka Tatomirovic, Marika Ljubenov, Slobodan Marjanović, Milomir Malesević
BACKGROUND/AIM: Peripheral blood (PB) is used more frequently as a source of stem cells (SCs) for allogeneic transplantation. However, the influence of cell source on the clinical outcome of SC transplantation is not yet well established. The aim of this study was to compare the results of PBSC transplantation (PBSCT) with bone marrow transplantation (BMT) on the basis of engraftment, frequency and severity of immediate (mucositis, acute Graft versus Host Disease--aGvHD) and delayed (chronic GvHD--cGvHD) complications, as well as transplant-related mortality (TRM), transfusion needs, relapses and overall survival (OS)...
December 2011: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
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