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https://www.readbyqxmd.com/read/29036982/-research-advances-on-the-relationship-between-nitrate-nitrite-no-pathway-and-heart-failure-with-preserved-ejection-fraction
#1
Y Meng, Z Y Zhang
No abstract text is available yet for this article.
September 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29036910/melatonin-treatment-reduces-oxidative-damage-and-normalizes-plasma-pro-inflammatory-cytokines-in-patients-suffering-from-charcot-marie-tooth-neuropathy-a-pilot-study-in-three-children
#2
Mariam Chahbouni, María Del Señor López, Antonio Molina-Carballo, Tomás de Haro, Antonio Muñoz-Hoyos, Marisol Fernández-Ortiz, Ana Guerra-Librero, Darío Acuña-Castroviejo
Charcot-Marie-Tooth neuropathy (CMT) is a motor and sensory neuropathy comprising a heterogeneous group of inherited diseases. The CMT1A phenotype is predominant in the 70% of CMT patients, with nerve conduction velocity reduction and hypertrophic demyelination. These patients have elevated oxidative stress and chronic inflammation. Currently, there is no effective cure for CMT; herein, we investigated whether melatonin treatment may reduce the inflammatory and oxidative damage in CMT1A patients. Three patients, aged 8-10 years, were treated with melatonin (60 mg at 21:00 h plus 10 mg at 09:00 h), and plasma levels of lipid peroxidation (LPO), nitrites (NOx), IL-1β, IL-2, IL-6, TNF-α, INF-γ, oxidized to reduced glutathione (GSSG/GSH) ratio, and the activities of superoxide dismutase (SOD), glutathione-S transferase (GST), glutathione peroxidase (GPx), and reductase (GRd), were determined in erythrocytes at 3 and 6 months of treatment...
October 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29036367/phenylalanine-as-a-nitrogen-source-induces-root-growth-and-nitrogen-use-efficiency-in-populus-%C3%A3-canescens
#3
Yu Jiao, Yinghao Chen, Chaofeng Ma, Jingjing Qin, Thi Hong Nhung Nguyen, Di Liu, Honghao Gan, Shen Ding, Zhi-Bin Luo
To investigate the physiological responses of poplars to amino acids as sole nitrogen (N) sources, Populus × canescens (Ait.) Smith plants were supplied with one of three nitrogen fertilizers (NH4NO3, phenylalanine (Phe) or the mixture of NH4NO3 and Phe) in sand culture. A larger root system, and decreased leaf size and CO2 assimilation rate was observed in Phe- versus NH4NO3-treated poplars. Consistently, a greater root biomass and a decreased shoot growth were detected in Phe-supplied poplars. Decreased enzymatic activities of nitrate reductase (NR), glutamate synthase (GOGAT) and glutamate dehydrogenase (GDH) and elevated activities of nitrite reductase (NiR), phenylalanine ammonia lyase (PAL), glutamine synthetase (GS) and asparagine synthase (AS) were found in Phe-treated roots...
September 19, 2017: Tree Physiology
https://www.readbyqxmd.com/read/29035260/nitrite-isotopes-as-tracers-of-marine-n-cycle-processes
#4
REVIEW
Karen L Casciotti
Nitrite (NO2(-)) is a key intermediate in the marine nitrogen (N) cycle. It is produced and consumed throughout the ocean by the dominant processes driving the distribution, availability and speciation of N. However, the accumulation of nitrite is typically confined to depths near the base of the sunlit euphotic zone and in oxygen-deficient zones. These features are known as the primary and secondary nitrite maximum (PNM and SNM), respectively. The processes controlling nitrite accumulation in these features are not fully understood, but are thought to depend on the microbial community composition and its response to environmental conditions...
November 28, 2016: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29035054/quantum-yields-of-nitrite-no2-from-the-photolysis-of-nitrate-no3-in-ice-at-313-nm
#5
Katherine Beem Benedict, Cort Anastasio
Photochemical reactions of nitrate in snow release reactive nitrogen species via two channels, which produce: (1) nitrogen dioxide (NO2) and hydroxyl radical ((•)OH), and (2) nitrite (NO2(-) ) and oxygen atom (O((3)P)). Quantum yields (Φ) for these channels are generally well characterized, except for channel 2 in ice. In this study, we quantify Φ(NO2(-) ) in water ices and examine the impacts of pH and organic scavengers of (•)OH. Compared to solution results, we find that nitrite quantum yields in ice are more sensitive to pH and that (•)OH scavengers are less effective, although 2-propanol appears to work well...
October 16, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29033090/the-antimicrobial-peptide-ll-37-as-a-possible-adjunct-for-the-proliferation-and-differentiation-of-dental-pulp-stem-cells
#6
Noala Vicensoto Moreira Milhan, Patricia Pimentel de Barros, Elis Andrade de Lima Zutin, Felipe Eduardo de Oliveira, Carlos Henrique Ribeiro Camargo, Samira Esteves Afonso Camargo
INTRODUCTION: This study evaluated the biocompatibility of 5 and 10 μg/mL LL-37 in vitro and its effect on the differentiation of human dental pulp stem cells (DPSCs) into odontoblast-like cells. METHODS: Cell viability, genotoxicity, nitric oxide production, cell cycle, dentine sialophosphoprotein (DSPP) production, and DSPP gene expression. RESULTS: Concentrations of 5 and 10 μg/mL of LL-37 were not cytotoxic and generally increased cell viability, especially on the third day (P < ...
October 12, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/29032304/heterocyclic-homoprostanoid-derivative-attenuates-monoarthritis-in-rats-an-in-vitro-and-in-vivo-preclinical-paradigm
#7
Jayesh Mudgal, S A Manohara Reddy, Geetha Mathew, Anoop Kishore, C Mallikarjuna Rao, Gopalan K Nampurath
From our lab, among the nineteen heterocyclic homoprostanoids (HHPs), three derivatives (compounds 3, 3b and 3c) exerted antioxidant and anti-inflammatory activity. Present study is an extension of the earlier work, and, is designed to establish their therapeutic potential in monoarthritis in rats. In addition, their possible mechanism of action would be investigated. A battery of in vitro tests such as lipopolysaccharide (LPS)-induced nitrite (NO)/reactive oxygen species (ROS) and NO/interleukin (IL)-6 generation in murine macrophages and whole blood (WhB), respectively were conducted...
October 12, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29032210/chemical-composition-of-cyclocarya-paliurus-polysaccharide-and-inflammatory-effects-in-lipopolysaccharide-stimulated-raw264-7-macrophage
#8
Lei-Xiong, Ke-Hui Ouyang, Yan-Jiang, Zhan-Wei Yang, Wen-Bing Hu, Hui-Chen, Ning-Wang, Xin-Liu, Wen-Jun Wang
This study was designed to study the chemical composition of Cyclocarya paliurus polysaccharide and inflammatory effects in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage. A new elution (0.3% NaCl aqueous solution) of Cyclocarya paliurus polysaccharide (CPP-3) was characterized by different methods such as fourier transform infrared spectra (FT-IR), UV-vis, gas chromatography-mass spectrometry (GC-MS), high performance gel chromatography (HPGLC) and scanning electron microscopy (SEM). Cell viability was measured by MTT test, phagocytosis assay was measured by Neutral red uptake assay, nitrite was measured by Griess assay, TNF-α and IL-1β analysis were measured by ELISA, PGE2 was measured by enzyme immunoassay system...
October 12, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29032054/role-of-ethanolic-extract-of-bacopa-monnieri-against-1-methyl-4-phenyl-1-2-3-6-tetrahydropyridine-mptp-induced-mice-model-via-inhibition-of-apoptotic-pathways-of-dopaminergic-neurons
#9
Babita Singh, Shivani Pandey, Satyndra Kumar Yadav, Rajesh Verma, Surya Pratap Singh, Abbas Ali Mahdi
Parkinson's disease (PD) is a neurodegenerative disease which causes rigidity, resting tremor and postural instability. The neuroprotective effects of an ethanolic extract of Bacopa monnieri (BM) were evaluated in a Parkinsonian mice model induced by the MPTP. The present study investigates the mechanisms of neuroprotection elicited by BM, an herb traditionally recognized by the Indian system of medicine, Ayurveda. An ethanolic extract of BM was co-treated with the MPTP induced mouse model of PD and was shown to significantly rescue the motor behaviour (Rotarod, Grip Strength and Foot Printing test)...
October 12, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/29032011/sitagliptin-enhances-the-neuroprotective-effect-of-pregabalin-against-pentylenetetrazole-induced-acute-epileptogenesis-in-mice-implication-of-oxidative-inflammatory-apoptotic-and-autophagy-pathways
#10
Manar A Nader, Hayam Ateyya, Mohamed El-Shafey, Nagla A El-Sherbeeny
The current investigation aimed at studying the anti-epileptogenic effect of sitagliptin. The possible effect of the drug in combination with pregabalin in pentylenetetrazole (PTZ)- induced seizures was studied. In addition, the postulated mechanisms that could mediate such effect were explored namely, suppression of oxidative stress and neuro-inflammatory markers, autophagy and apoptosis. Seven days prior to PTZ (60 mg/kg, sc) injection, mice were treated with sitagliptin (5, 15, and 60 mg/kg, twice daily, orally) or pregabalin (30 mg/kg, once daily, orally) or their combination...
October 11, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/29031221/effects-of-particulate-matter-from-straw-burning-on-lung-fibrosis-in-mice
#11
Yang Hu, Liu-Sheng Wang, Yan Li, Qiu-Hong Li, Chun-Lin Li, Jian-Min Chen, Dong Weng, Hui-Ping Li
OBJECTIVE: To investigate the impacts of particulate matter 2.5 (PM2.5) from straw burning on the acute exacerbation of lung fibrosis in mice and the preventive effects of N-acetylcysteine (NAC). METHODS: The composition, particle size, and 30-min concentration change in an exposure system of the PM2.5 from straw-burning were determined. Forty C57BL male mice were equally randomized to two groups: bleomycin (BLM)-induced lung fibrosis with an exposure to air (BLM+air) and BLM+PM2...
October 7, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29030007/pretreatment-of-a-matrix-metalloproteases-inhibitor-and-aprotinin-attenuated-the-development-of-acute-pancreatitis-induced-lung-injury-in-rat-model
#12
Kuang-En Chu, Yao Fong, David Wang, Chao Fuh Chen, Diana Yu-Wung Yeh
OBJECTIVE: Acute lung injury (ALI) is one of the most common extra-pancreatic complications of acute pancreatitis. In this study, we examined the protective effect of protease inhibitor aprotinin and a matrix metalloproteinase inhibitor (MMPi) on pulmonary inflammation in rats with severe pancreatitis-associated ALI. METHOD: A rat model of acute pancreatitis (AP) was established by injecting sodium glycodeoxycholate (GDOC) into the pancreatic duct. Pharmacological interventions included pretreatment with a protease inhibitor aprotinin (10mg/kg) and a matrix metalloproteinase inhibitor (MMPi, 100g/kg)...
October 6, 2017: Immunobiology
https://www.readbyqxmd.com/read/29029736/rapid-visual-and-spectrophotometric-nitrite-detection-by-cyclometalated-ruthenium-complex
#13
Hoi-Shing Lo, Ka-Wai Lo, Chi-Fung Yeung, Chun-Yuen Wong
Quantitative determination of nitrite ion (NO2(-)) is of great importance in environmental and clinical investigations. A rapid visual and spectrophotometric assay for NO2(-) detection was developed based on a newly designed ruthenium complex, [Ru(npy)([9]aneS3)(CO)](ClO4) (denoted as RuNPY; npy = 2-(1-naphthyl)pyridine, [9]aneS3 = 1,4,7-trithiacyclononane). This complex traps NO(+) produced in acidified NO2(-) solution, and yields observable color change within 1 min at room temperature. The assay features excellent dynamic range (1-840 μmol L(-1)) and high selectivity, and its limit of detection (0...
October 16, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29029361/the-mechanism-of-attenuation-of-epithelial-mesenchymal-transition-by-a-phosphodiesterase-5-inhibitor-via-renal-klotho-expression
#14
Seung Tae Han, Jae Seok Kim, Jun Young Lee, Min Keun Kim, Jin Sae Yoo, Byoung Geun Han, Seung Ok Choi, Jae Won Yang
OBJECTIVES: Phosphodiesterase-5 (PDE-5) inhibitors induces vasodilation in several organs by blocking cyclic GMP (guanosine monophosphate) degradation. However, the existence of alternative mechanism of action in case of an impaired nitric oxide (NO) system remains controversial. Previous studies suggested that decreased NO bioavailability may result in the down-regulation of klotho expression, but the relationship between klotho and NO remains obscure. Therefore, we investigated whether a PDE-5 inhibitor could preserve epithelial mesenchymal transition (EMT) and relationship exists between the NO and renal klotho expression...
October 13, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29026935/temporal-spatial-evolution-of-groundwater-nitrogen-pollution-over-seven-years-in-a-highly-urbanized-city-in-the-southern-china
#15
Xiaorui He, Jiazhong Qian, Zufa Liu, Yuehan Lu, Lei Ma, Weidong Zhao, Bo Kang
Understanding the temporospatial variation in nitrogen pollution in groundwater and the associated controlling factors is important to establish management practices that ensure sustainable use of groundwater. In this study, we analyzed inorganic nitrogen content (nitrate, nitrite, and ammonium) in 1164 groundwater samples from shallow, middle-deep, and deep aquifers in Zhanjiang, a highly urbanized city in the southern China. Our data span a range of 7 years from 2005 to 2011. Results show that shallow aquifers had been heavily contaminated by nitrate and ammonium...
October 12, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29026794/nitrite-and-nitrate-concentrations-in-the-drinking-groundwater-of-shiraz-city-south-central-iran-by-statistical-models
#16
Ahmad Badee Nezhad, Mohammad Mahdi Emamjomeh, Mahdi Farzadkia, Ahmad Jonidi Jafari, Mehrab Sayadi, Amir Hossein Davoudian Talab
BACKGROUND: Nitrite (NO2-) and nitrate (NO3-) contaminations of groundwater are considered as one of the major health challenges in recent decades. This study aimed to evaluate the nitrite and nitrate concentrations in the drinking groundwater of Shiraz, South-central Iran by statistical models. METHODS: From 43 active wells of Shiraz drinking water supplies, 344 samples were collected in the high and low precipitation seasons from 2010 to 2014. Nitrate and nitrite concentrations were tested by a DR6000 spectrophotometer, and the results were analyzed by different software, including SPSS ver...
September 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29025575/biomarkers-in-pulmonary-vascular-disease-gauging-response-to-therapy
#17
Timothy J McMahon, Nathan S Bryan
Biomarkers are increasingly being investigated in the treatment of pulmonary vascular disease. In particular, the signaling pathways targeted by therapies for pulmonary arterial hypertension provide biomarkers that potentially can be used to guide therapy and to assess clinical response as an alternative to invasive procedures such as right-sided cardiac catheterization. Moreover, the growing use of combination therapy for both the initial and subsequent treatment of pulmonary arterial hypertension highlights the need for biomarkers in this treatment approach...
October 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29025175/-multifocal-electroretinography-in-patients-with-poppers-maculopathy
#18
Milena Pahlitzsch, Daniel Salchow, Mirjam Rossel, Richard Bergholz
Background Maculopathy is a potential side effect of amyl nitrite or "poppers" abuse. It is characterized by a sudden, painless decrease in visual acuity. While the funduscopic changes are subtle, optical coherence tomography shows alterations of the outer retinal layers in the fovea. However, the extent of retinal dysfunction remains poorly understood. Materials/Methods We compared the multifocal electroretinogram of 6 patients with poppers maculopathy to that of a control group consisting of 6 healthy subjects...
October 12, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29024098/hemin-graphene-derivatives-with-increased-peroxidase-activities-restrain-protein-tyrosine-nitration
#19
Huan Xu, Zhen Yang, Hailing Li, Zhonghong Gao
Protein tyrosine nitration is implicated in the occurrence and progression of pathological conditions involved with free radical reactions. It is well-recognized that hemin can catalyze protein tyrosine nitration in the presence of nitrite and hydrogen peroxide. Generally, the catalytical efficiency is positively correlated to its peroxidase activity. In this study, however, it was found that the efficiency of hemin in catalyzing protein tyrosine nitration was largely suppressed after functionalization with graphene derivatives, even though its peroxidase-like activity increased more than quadrupled...
October 10, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29023147/nitrogen-oxides-in-early-earth-s-atmosphere-as-electron-acceptors-for-life-s-emergence
#20
Michael L Wong, Benjamin D Charnay, Peter Gao, Yuk L Yung, Michael J Russell
We quantify the amount of nitrogen oxides (NOx) produced through lightning and photochemical processes in the Hadean atmosphere to be available in the Hadean ocean for the emergence of life. Atmospherically generated nitrate (NO3(-)) and nitrite (NO2(-)) are the most attractive high-potential electron acceptors for pulling and enabling crucial redox reactions of autotrophic metabolic pathways at submarine alkaline hydrothermal vents. The Hadean atmosphere, dominated by CO2 and N2, will produce nitric oxide (NO) when shocked by lightning...
October 12, 2017: Astrobiology
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