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Athenas protocol

Claudia Sommerer, Barbara Suwelack, Duska Dragun, Peter Schenker, Ingeborg A Hauser, Björn Nashan, Friedrich Thaiss
BACKGROUND: Immunosuppression with calcineurin inhibitors remains the mainstay of treatment after kidney transplantation; however, long-term use of these drugs may be associated with nephrotoxicity. In this regard, the current approach is to optimise available immunosuppressive regimens to reduce the calcineurin inhibitor dose while protecting renal function without affecting the efficacy. The ATHENA study is designed to evaluate renal function in two regimens: an everolimus and reduced calcineurin inhibitor-based regimen versus a standard treatment protocol with mycophenolic acid and tacrolimus in de novo kidney transplant recipients...
2016: Trials
Hui-Fen Mao, Ling-Hui Chang, Athena Yi-Jung Tsai, Wen-Ni Huang, Jye Wang
Because resources for long-term care services are limited, timely and appropriate referral for rehabilitation services is critical for optimizing clients' functions and successfully integrating them into the community. We investigated which client characteristics are most relevant in predicting Taiwan's community-based occupational therapy (OT) service referral based on experts' beliefs. Data were collected in face-to-face interviews using the Multidimensional Assessment Instrument (MDAI). Community-dwelling participants (n = 221) ≥ 18 years old who reported disabilities in the previous National Survey of Long-term Care Needs in Taiwan were enrolled...
2016: PloS One
Iwona Sudoł-Szopińska, Anne Grethe Jurik, Iris Eshed, Jans Lennart, Andrew Grainger, Mikkel Østergaard, Andrea Klauser, Anne Cotten, Marius C Wick, Mario Maas, Falk Miese, Niels Egund, Nathalie Boutry, Mitja Rupreht, Monique Reijnierse, Edwin H G Oei, Reinhard Meier, Phil O'Connor, Antoine Feydy, Vasco Mascarenhas, Athena Plagou, Paolo Simoni, Hannes Platzgummer, Winston J Rennie, Adam Mester, James Teh, Philip Robinson, Giuseppe Guglielmi, Gunnar Åström, Claudia Schueller-Weiderkamm
This article presents the recommendations of the European Society of Musculoskeletal Radiology Arthritis Subcommittee regarding the standards of the use of MRI in the diagnosis of musculoskeletal rheumatic diseases. The recommendations discuss (1) the role of MRI in current classification criteria of musculoskeletal rheumatic diseases (including early diagnosis of inflammation, disease follow-up, and identification of disease complications); (2) the impact of MRI on the diagnosis of axial and peripheral spondyloarthritis, rheumatoid arthritis, and juvenile spondyloarthritis; (3) MRI protocols for the axial and peripheral joints; (4) MRI interpretation and reporting for axial and peripheral joints; and finally, (5) methods for assessing MR images including quantitative, semiquantitative, and dynamic contrast-enhanced MRI studies...
September 2015: Seminars in Musculoskeletal Radiology
Mikaela Smit, Kees Brinkman, Suzanne Geerlings, Colette Smit, Kalyani Thyagarajan, Ard van Sighem, Frank de Wolf, Timothy B Hallett
BACKGROUND: The population infected with HIV is getting older and these people will increasingly develop age-related non-communicable diseases (NCDs). We aimed to quantify the scale of the change and the implications for HIV care in the Netherlands in the future. METHODS: We constructed an individual-based model of the ageing HIV-infected population, which followed patients on HIV treatment as they age, develop NCDs-including cardiovascular disease (hypertension, hypercholesterolaemia, myocardial infarctions, and strokes), diabetes, chronic kidney disease, osteoporosis, and non-AIDS malignancies-and start co-medication for these diseases...
July 2015: Lancet Infectious Diseases
Andrew M Evens, Jennifer A Kanakry, Laurie H Sehn, Athena Kritharis, Tatyana Feldman, Aimee Kroll, Randy D Gascoyne, Jeremy S Abramson, Adam M Petrich, Francisco J Hernandez-Ilizaliturri, Zeina Al-Mansour, Camille Adeimy, Jessica Hemminger, Nancy L Bartlett, Anthony Mato, Paolo F Caimi, Ranjana H Advani, Andreas K Klein, Chadi Nabhan, Sonali M Smith, Jesus C Fabregas, Izidore S Lossos, Oliver W Press, Timothy S Fenske, Jonathan W Friedberg, Julie M Vose, Kristie A Blum
Gray zone lymphoma (GZL) with features between classical Hodgkin lymphoma and diffuse large B-cell lymphoma (DLBCL) is a recently recognized entity reported to present primarily with mediastinal disease (MGZL). We examined detailed clinical features, outcomes, and prognostic factors among 112 GZL patients recently treated across 19 North American centers. Forty-three percent of patients presented with MGZL, whereas 57% had non-MGZL (NMGZL). NMGZL patients were older (50 versus 37 years, P = 0.0001); more often had bone marrow involvement (19% versus 0%, P = 0...
September 2015: American Journal of Hematology
Athena Kritharis, Michael Coyle, Jaya Sharma, Andrew M Evens
Lenalidomide is an immunomodulatory drug (IMiD) with activity in lymphoid malignancies occurring primarily through immune modulation (eg, T-cell immune synapse enhancement and NK-cell/T-cell effector augmentation) and antiproliferative effects. Food and Drug Administration-approved for bortezomib-resistant, relapsed/refractory mantle-cell lymphoma, lenalidomide has demonstrated efficacy in several additional lymphoma subtypes. There are many ongoing clinical trials examining the use of lenalidomide alone or in combinatorial therapy...
April 16, 2015: Blood
Camille Chatelle, Aurore Thibaut, Olivia Gosseries, Marie-Aurélie Bruno, Athena Demertzi, Claire Bernard, Roland Hustinx, Luaba Tshibanda, Mohamed A Bahri, Steven Laureys
BACKGROUND: Zolpidem, a short-acting non-benzodiazepine GABA agonist hypnotic, has been shown to induce paradoxical responses in some patients with disorders of consciousness (DOC), leading to recovery of arousal and cognitive abilities. We here assessed zolpidem-induced changes in regional brain metabolism in three patients with known zolpidem response in chronic post-anoxic minimally conscious state (MCS). METHODS: [18F]-fluorodeoxyglucose positron emission tomography (FDG-PET) and standardized clinical assessments using the Coma Recovery Scale-Revised were performed after administration of 10 mg zolpidem or placebo in a randomized double blind 2-day protocol...
2014: Frontiers in Human Neuroscience
Pengbo Jiang, Athena Christakos, Mina Fam, Hossein Sadeghi-Nejad
PURPOSE: Although penile duplex Doppler ultrasonography (PDDU) is a common and integral procedure in a Peyronie's disease workup, the intracavernosal injection of vasoactive agents can carry a serious risk of priapism. Risk factors include young age, good baseline erectile function, and no coronary artery disease. In addition, patients with Peyronie's disease undergoing PDDU in an outpatient setting are at increased risk given the inability to predict optimal dosing. The present study was conducted to provide support for a standard protocol of early administration of phenylephrine in patients with a sustained erection after diagnostic intracavernosal injection of vasoactive agents to prevent the deleterious effects of iatrogenic priapism...
October 2014: Korean Journal of Urology
Giuseppina Sanna, Alessandra Fabi, Diana Crivellari, Silvana Saracchini, Nicola Battelli, Cecilia Nisticò, Alba Maria Capobianco, Germano Zampa, Alberto Bottini, Salvatore Del Prete, Edda Simoncini, Anna Galli, Manuela Matasconi, Eleonora Restuccia, Laura Biganzoli
AIMS AND BACKGROUND: The ATHENA international study investigated the safety and efficacy of bevacizumab plus first-line chemotherapy in locally recurrent/metastatic breast cancer in routine oncology practice. The present paper focuses on the outcomes of the Italian cohort of the study. METHODS: A subgroup analysis was carried out to report on the safety (primary endpoint) and efficacy (secondary endpoint) outcomes of patients recruited from Italian Centers. RESULTS: A total of 278 patients were included...
July 2014: Tumori
Jean-Yves Pierga, Rémy Delva, Xavier Pivot, Marc Espié, Florence Dalenc, Daniel Serin, Corinne Veyret, Alain Lortholary, Joseph Gligorov, Katelle Joly, Juana Hernandez, Anne-Claire Hardy-Bessard
The international phase IIIb study, ATHENA assessed the combination of bevacizumab/taxane-based chemotherapy in the first-line treatment of HER2 negative metastatic breast cancer (mBC) in real-life setting. Among the 365 patients included in France, median overall survival (OS) is 28.4 months (CI95% 24.8-33.0), with a median time from treatment start to end of study of 36,5 months (25,1-45,4). Exploratory analyses in three sub-groups show that the median OS in long responder patients (not progressing for at least one year; n = 116) is not reached...
September 2014: Bulletin du Cancer
Claudia Schueller-Weidekamm, Vasco V Mascarenhas, Iwona Sudol-Szopinska, Nathalie Boutry, Athena Plagou, Andrea Klauser, Marius Wick, Hannes Platzgummer, Lennart Jans, Adam Mester, Franz Kainberger, Gunnar Aström, Giuseppe Guglielmi, Iris Eshed
This article reflects the radiologist's perspective on the imaging and interpretation of axial spondylarthritis (SpA). The arthritis subcommittee of the European Society of Skeletal Radiology provides a consensus for the following questions: When and how should we image? How should we analyze the images? How should we interpret the imaging findings? To answer these questions, we address the indications in imaging axial SpA and the different imaging techniques, with a special focus on magnetic resonance imaging protocols...
July 2014: Seminars in Musculoskeletal Radiology
Heesun J Rogers, James W Vardiman, John Anastasi, Gordana Raca, Natasha M Savage, Athena M Cherry, Daniel Arber, Erika Moore, Jennifer J D Morrissette, Adam Bagg, Yen-Chun Liu, Susan Mathew, Attilio Orazi, Pei Lin, Sa A Wang, Carlos E Bueso-Ramos, Kathryn Foucar, Robert P Hasserjian, Ramon V Tiu, Matthew Karafa, Eric D Hsi
Acute myeloid leukemia and myelodysplastic syndrome with inv(3)(q21q26.2)/t(3;3)(q21;q26.2) have a poor prognosis. Indeed, the inv(3)(q21q26.2)/t(3;3)(q21;q26.2) has been recognized as a poor risk karyotype in the revised International Prognostic Scoring System. However, inv(3)(q21q26.2)/t(3;3)(q21;q26.2) is not among the cytogenetic abnormalities pathognomonic for diagnosis of acute myeloid leukemia irrespective of blast percentage in the 2008 WHO classification. This multicenter study evaluated the clinico-pathological features of acute myeloid leukemia/myelodysplastic syndrome patients with inv(3)(q21q26...
May 2014: Haematologica
Laura Mendoza, Athena Gogali, Dinesh Shrikrishna, Gabriel Cavada, Samuel V Kemp, Samantha A Natanek, Abigail S Jackson, Michael I Polkey, Athol U Wells, Nicholas S Hopkinson
BACKGROUND AND OBJECTIVE: Quadriceps muscle dysfunction is an important contributor to exercise limitation in chronic obstructive pulmonary disease, but little is known about skeletal muscle function and its impact on exercise capacity in patients with fibrotic idiopathic interstitial pneumonia (IIP). The aim of the study was to compare quadriceps strength and endurance in patients with fibrotic IIP and healthy controls, and relate it to exercise capacity. METHODS: Quadriceps strength and endurance, as well as respiratory muscle strength, and 6-min walk distance were compared among 25 patients with fibrotic IIP, forced vital capacity mean (standard deviation) 78...
January 2014: Respirology: Official Journal of the Asian Pacific Society of Respirology
Sarah L Elson, Robert A Hiatt, Hoda Anton-Culver, Lydia P Howell, Arash Naeim, Barbara A Parker, Laura J Van't Veer, Michael Hogarth, John P Pierce, Robert J Duwors, Kathy Hajopoulos, Laura J Esserman
The term breast cancer covers many different conditions, whose clinical course ranges from indolent to aggressive. However, current practice in breast cancer prevention and care, and in breast cancer epidemiology, does not take into account the heterogeneity of the disease. A comprehensive understanding of the etiology and progression of different breast cancer subtypes would enable a more patient-centered approach to breast health care: assessing an individual's risk of getting specific subtypes of the disease, providing risk-based screening and prevention recommendations, and, for those diagnosed with the disease, tailored treatment options based on risk and timing of progression and mortality...
July 2013: Breast Cancer Research and Treatment
Athena Kritharis, Thomas P Bradley, Daniel R Budman
For more than 2,000 years, arsenic and its derivatives have shown medical utility. Owing to the toxicities and potential carcinogenicity of arsenicals, their popularity has fluctuated. The exact mechanism of action of therapeutic arsenic is not well characterized but likely to involve apoptosis, generation of reactive oxygen species, inhibition of intracellular transduction pathways, and cell functions. Arsenic trioxide has received approval for use in patients with relapsed acute promyelocytic leukemia for remission induction...
June 2013: Annals of Hematology
Benoît Chauvin, Bogdan I Iorga, Pierre Chaminade, Jean-Louis Paul, Philippe Maillard, Patrice Prognon, Athena Kasselouri
In the course of a Photodynamic Therapy (PDT) protocol, disaggregation of the sensitizer upon binding to plasma proteins and lipoproteins is one of the first steps following intravenous administration. This step governs its subsequent biodistribution and has even been evoked as possibly orientating mechanism of tumor destruction. It is currently admitted as being mainly dependent on sensitizer's hydrophobicity. In this context, as far as glycoconjugation of meso-tetraphenylporphyrin (TPP) macrocycle, a promising strategy to improve targeting of retinoblastoma cells confers to the sensitizer an amphiphilic character, we have studied the effect of this strategy on binding to plasma proteins and lipoproteins...
February 2013: European Journal of Pharmaceutics and Biopharmaceutics
Anne-Claire Hardy-Bessard, Rémy Delva, Xavier Pivot, Marc Espié, Florence Dalenc, Marie-Aude Coulon Sfairi, Alain Monnier, Daniel Serin, Corinne Veyret, Alain Lortholary, Maria Pavlyuk, Leila Kockler, Jean-Yves Pierga
The efficacy of the combination bevacizumab-chemotherapy in the first-line treatment of metastatic breast cancer (mBC) was demonstrated in several randomized clinical trials. However, limited safety data is available in daily medical practice. ATHENA is an international phase-IIIb study conducted in 2,251 patients with locally advanced or mBC, treated in first-line with bevacizumab combined with taxanes-based chemotherapy. The primary objective is safety assessment. In France, 365 patients were included. Their median age was 56 years (24-93 years) and ECOG performance status was 0 or 1 in 93...
June 2012: Bulletin du Cancer
Elsa Jungman, Cécile Laugel, Athéna Kasselouri, Arlette Baillet-Guffroy
Considering that the skin barrier properties are closely linked to the ceramides composition and conformation within the SC, our work focused on developing a new evaluation criterion in complement of the Log Pow and MW: lipids retentive role within the SC. We developed an in vitro model to study exogenous molecules (Mol) and SC lipids interaction by fluorescence spectroscopy. As ceramides do not fluoresce, fluorescence probes that emit a fluorescence signal in contact with lipidic chains were selected for the study...
September 15, 2012: International Journal of Pharmaceutics
H Jean Khoury, Jorge E Cortes, Hagop M Kantarjian, Carlo Gambacorti-Passerini, Michele Baccarani, Dong-Wook Kim, Andrey Zaritskey, Athena Countouriotis, Nadine Besson, Eric Leip, Virginia Kelly, Tim H Brümmendorf
Bosutinib, a dual Src/Abl tyrosine kinase inhibitor (TKI), has shown potent activity against chronic myeloid leukemia (CML). This phase 1/2 study evaluated the efficacy and safety of once-daily bosutinib 500 mg in leukemia patients after resistance/intolerance to imatinib. The current analysis included 118 patients with chronic-phase CML who had been pretreated with imatinib followed by dasatinib and/or nilotinib, with a median follow-up of 28.5 months. In this subpopulation, major cytogenetic response was attained by 32% of patients; complete cytogenetic response was attained by 24%, including in one of 3 patients treated with 3 prior TKIs...
April 12, 2012: Blood
Athanasios Pilalis, Constantinos Basagiannis, Makarios Eleftheriades, Efthimios Faros, Elias Troukis, Eleni Armelidou, Ioannis Papastefanou, Athena P Souka
OBJECTIVE: To evaluate a two-step screening protocol of ultrasound examinations (11-14 and 20-24 weeks) for the detection of major fetal structural defects. METHODS: Retrospective study in a private maternity hospital. Women with viable singleton pregnancies having both first trimester scan and anomaly scan at our department and subsequently delivered at our hospital were included. Major fetal structural defects were defined as those requiring medical or surgical treatment or those causing mental handicap...
September 2012: Journal of Maternal-fetal & Neonatal Medicine
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