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Psc OR primary sclerosing cholangitis

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https://www.readbyqxmd.com/read/29663389/noncholesterol-sterols-as-surrogate-markers-in-patients-with-severe-alcoholic-hepatitis
#1
Perttu Sahlman, Markku Nissinen, Piia Simonen, Martti Färkkilä
Severe alcoholic hepatitis (AH) is a life-threatening condition lacking good serologic markers to tailor treatment and predict recovery. We examined the cholesterol metabolism in severe AH to explore prognostic markers and evaluate the profile of cholesterol precursors, cholestanol and phytosterols, in this context. We assessed serum cholesterol, cholesterol precursors, cholestanol, phytosterols, and biochemical markers in 24 patients with severe AH treated with prednisolone and randomized to ciprofloxacin in the ratio 1:1...
April 16, 2018: Lipids
https://www.readbyqxmd.com/read/29658203/crohn-s-disease-behavior-and-location-is-altered-when-associated-with-primary-sclerosing-cholangitis
#2
Oren Iny, Henit Yanai, Shay Matalon, Erwin Santo, Oren Shibolet, Iris Dotan, Nitsan Maharshak
BACKGROUND: Up to 3.4% of Crohn's disease (CD) patients will be diagnosed with concomitant primary sclerosing cholangitis (PSC). Despite the worldwide increase incidence of CD, data on the clinical characteristics of PSC-CD patients are scarce. OBJECTIVES: To clinically characterize CD in patients who have concomitant PSC. METHODS: A retrospective case-control analysis was conducted with 18 CD patients with concomitant PSC who attended the Inflammatory Bowel Disease Center at the Tel Aviv Sourasky Medical Center between 2011-2014 (PSC-CD patients)...
January 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29655972/effectiveness-and-safety-of-anti-tnf-therapy-for-inflammatory-bowel-disease-in-liver-transplant-recipients-for-primary-sclerosing-cholangitis-a-nationwide-case-series
#3
Romain Altwegg, Roman Combes, David Laharie, Victor De Ledinghen, Sylvie Radenne, Filomena Conti, Olivier Chazouilleres, Christophe Duvoux, Jérôme Dumortier, Vincent Leroy, Xavier Treton, François Durand, Sébastien Dharancy, Maria Nachury, Félix Goutorbe, Géraldine Lamblin, Lucile Boivineau, Laurent Peyrin-Biroulet, Georges-Philippe Pageaux
BACKGROUND: There is a lack of consensus regarding the treatment of inflammatory bowel disease (IBD) after liver transplantation (LT) forprimary sclerosing cholangitis (PSC). AIM: To investigate the safety and effectiveness of anti-TNF therapy in patients with IBD after a LT for PSC. METHODS: We reviewed the medical files of all of the IBD patients who underwent a LT for PSC and who were treated with anti-TNF therapy at 23 French liver transplantation centers between 1989 and 2012...
March 13, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29655526/association-between-appendectomy-and-risk-of-primary-sclerosing-cholangitis-a-systematic-review-and-meta-analysis
#4
Karn Wijarnpreecha, Panadeekarn Panjawatanan, Omar Y Mousa, Wisit Cheungpasitporn, Surakit Pungpapong, Patompong Ungprasert
BACKGROUND/OBJECTIVES: Recent epidemiologic studies have suggested that appendectomy could be a risk factor for primary sclerosing cholangitis (PSC) although the results were inconsistent. This systematic review and meta-analysis was conducted to summarize all available evidence. METHODS: A comprehensive literature review was conducted using MEDLINE and EMBASE database through January 2018 to identify all studies that reported the risk of PSC among individuals who had appendectomy versus those with no history of appendectomy...
April 11, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29651370/effect-of-the-specific-carbohydrate-diet-on-the-microbiome-of-a-primary-sclerosing-cholangitis-and-ulcerative-colitis-patient
#5
Alanna Dubrovsky, Christopher L Kitts
A 20-year-old female was diagnosed with ulcerative colitis (UC) at age 14 and primary sclerosing cholangitis (PSC) at age 16. The PSC was successfully treated with high doses of oral vancomycin; however, the UC was more difficult to manage. After many drug treatments failed to treat the UC, the patient began following the specific carbohydrate diet (SCD). This report documents fecal microbiome changes resulting from following the SCD for two weeks. The DNA extracted from fecal samples was subjected to 16S rRNA gene sequencing to quantify bacterial species abundance...
February 9, 2018: Curēus
https://www.readbyqxmd.com/read/29644745/editorial-vancomycin-a-promising-option-for-the-treatment-of-primary-sclerosing-cholangitis
#6
EDITORIAL
R W Chapman
No abstract text is available yet for this article.
May 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29626258/mr-elastography-in-primary-sclerosing-cholangitis-correlating-liver-stiffness-with-bile-duct-strictures-and-parenchymal-changes
#7
Candice A Bookwalter, Sudhakar K Venkatesh, John E Eaton, Thomas D Smyrk, Richard L Ehman
AIM: To determine correlation of liver stiffness measured by MR Elastography (MRE) with biliary abnormalities on MR Cholangiopancreatography (MRCP) and MRI parenchymal features in patients with primary sclerosing cholangitis (PSC). METHODS: Fifty-five patients with PSC who underwent MRI of the liver with MRCP and MRE were retrospectively evaluated. Two board-certified abdominal radiologists in agreement reviewed the MRI, MRCP, and MRE images. The biliary tree was evaluated for stricture, dilatation, wall enhancement, and thickening at segmental duct, right main duct, left main duct, and common bile duct levels...
April 7, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29615776/dysbiosis-of-the-salivary-microbiota-in-pediatric-onset-primary-sclerosing-cholangitis-and-its-potential-as-a-biomarker
#8
Kentaro Iwasawa, Wataru Suda, Tomoyuki Tsunoda, Manari Oikawa-Kawamoto, Shuichiro Umetsu, Lena Takayasu, Ayano Inui, Tomoo Fujisawa, Hidetoshi Morita, Tsuyoshi Sogo, Masahira Hattori
Primary sclerosing cholangitis (PSC) is a liver disease known for its frequent concurrence with inflammatory bowel disease. Dysbiosis of the gut microbiota in PSC was reported in several studies, but the microbiological features of the salivary microbiota in PSC have not been established. Here we compared the salivary microbial communities of 24 pediatric-onset PSC patients, 16 age-matched ulcerative colitis (UC) patients, and 24 healthy controls (HCs) by analyzing the bacterial 16S rRNA gene sequence data...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29610975/prognostic-factors-for-long-term-survival-after-adult-liver-transplantation
#9
Soufiane Filali Bouami, Jill Gwiasda, Jan Beneke, Alexander Kaltenborn, Sebastian Liersch, Eduardo M Suero, Hans-Friedrich Koch, Christian Krauth, Jürgen Klempnauer, Harald Schrem
PURPOSE: Prognostic factors for survival ≥ 15 years and life years lost after liver transplantation are largely unknown. METHODS: One thousand six hundred thirty primary adult liver transplants between 1983 and 2014 were analyzed. Risk factors for survival were identified with multivariable Cox regression and subsequently tested for their relevance as prognostic factors for observed 15-year survival using multivariable logistic regression and c statistics. The difference of life expectancy between a matched national reference population and survival in patients with post-transplant survival ≥ 15 years was calculated...
April 2, 2018: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/29607530/systematic-review-drug-induced-liver-injury-alternative-causes-in-case-series-as-confounding-variables
#10
REVIEW
Rolf Teschke, Gaby Danan
AIMS: Drug-induced liver injury (DILI) is rare as compared to the worldwide frequent acute or chronic liver diseases. Therefore, patients included in series of suspected DILI are at high risk of not having DILI, whereby alternative causes may confound the DILI diagnosis. The aim of this review is to evaluate published case series of DILI for alternative causes. METHODS: Pertinent studies were identified using a computerized search of the Medline database for publications from 1993 through 30 October 2017...
April 1, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29603453/prognosis-of-psc-time-to-look-at-the-population-as-a-whole-not-only-from-the-center-s-or-waiting-list-perspective
#11
Wolf Bechstein, Andreas Schnitzbauer
Equitable and fair allocation of liver grafts remains a challenge in transplantation of organs from deceased donors. Both the prognosis with and without transplantation should to be reliably assessed when deciding which patient should be preferred during the allocation process. In this issue of the journal, Goet et al. present their analysis of the current policy regarding allocation of donor livers for patients with primary sclerosing cholangitis (PSC) in the Netherlands (NL) who were entered unto the Eurotransplant (ET) waiting list during a 7 year period from December 2006 through December 2013...
March 30, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29603385/downregulated-eosinophil-activity-in-ulcerative-colitis-with-concomitant-primary-sclerosing-cholangitis
#12
Maria Lampinen, Annika Fredricsson, Johan Vessby, Johana Fernandez Martinez, Alkwin Wanders, Fredrik Rorsman, Marie Carlson
Primary sclerosing cholangitis (PSC) is a chronic bile duct inflammation strongly connected to ulcerative colitis (UC). PSC is associated with an increased risk of colon cancer, but the link between the intestinal and the bile duct inflammation is still unknown. Also, the involvement of intestinal immune cells in the pathogenesis of PSC remains to be determined. The eosinophil granulocyte is one of the immune cells implicated in the inflammatory process of ulcerative colitis. This study was performed to determine how the accumulation and activation of intestinal eosinophils may differ between UC with and without concomitant PSC, and how this may be influenced by the cytokine/chemokine profile of the intestinal compartment...
March 30, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29601088/blocking-h1-h2-histamine-receptors-inhibits-damage-fibrosis-in-mdr2-mice-and-human-cholangiocarcinoma-tumorigenesis
#13
Lindsey Kennedy, Laura Hargrove, Jennifer Demieville, Allen Karstens, Hannah Jones, Sharon DeMorrow, Fanyin Meng, Pietro Invernizzi, Francesca Bernuzzi, Gianfranco Alpini, Steven Smith, Austin Akers, Victoria Meadows, Heather Francis
BACKGROUND: Primary Sclerosing Cholangitis (PSC) patients are at risk of developing cholangiocarcinoma (CCA). We have shown that: (i) histamine (HA) increases biliary hyperplasia via H1/H2 histamine receptors (HRs) and (ii) HA levels increase and mast cells (MCs) infiltrate during PSC and CCA. We aimed to examine the effects of chronic treatment with H1/H2HR antagonists on PSC and CCA. METHODS: Wild-type and Mdr2-/- mice were treated by osmotic minipumps with saline, mepyramine or ranitidine (10mg/kg BW/day) or a combination of mepyramine/ranitidine for 4 wks...
March 30, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29590158/significance-of-serological-markers-in-the-disease-course-of-ulcerative-colitis-in-a-prospective-clinical-cohort-of-patients
#14
Gyorgy Kovacs, Nora Sipeki, Boglarka Suga, Tamas Tornai, Kai Fechner, Gary L Norman, Zakera Shums, Peter Antal-Szalmas, Maria Papp
BACKGROUND & AIMS: To determine the prognostic potential of classic and novel serologic antibodies regarding unfavorable disease course in a prospective ulcerative colitis (UC) patient cohort, since few and conflicting data are available in the literature regarding this matter. METHODS: 187 consecutive patients were studied prospectively (median follow-up: 135 months) from a single referral IBD center in Hungary. Sera were tested for different IgA/IgG type autoantibodies (anti-neutrophil cytoplasmic [ANCA], anti-DNA-bound-lactoferrin [anti-LFS], anti-goblet cell [anti-GAB] and anti-pancreatic [PAB: anti-CUZD1 and anti-GP2)]) by indirect immunofluorescence technique and for anti-microbial (anti-Saccharomyces cerevisiae [ASCA] IgG/IgA and anti-OMP Plus™ IgA) antibodies by enzyme-linked immunosorbent assays...
2018: PloS One
https://www.readbyqxmd.com/read/29579869/efficacy-and-safety-of-anti-tnf-%C3%AE-agents-in-inflammatory-bowel-disease-after-liver-transplant-a-case-series
#15
R V Olmedo-Martín, V Amo-Trillo, R González-Grande, E Tenorio-González, O Sánchez-García, J de la Cruz-Lombardo, J M Rodrigo-López, M Jiménez-Pérez
BACKGROUND: Ulcerative colitis (UC) and Crohn disease (CD) can appear de novo or worsen after liver transplant. Our aim was to assess the efficacy and safety of anti-tumor necrosis-alpha (anti-TNF-α) agents after transplantation. METHODS: We reviewed the clinical database of our center searching for all liver transplant patients with inflammatory bowel disease who were treated with anti-TNF-α agents between 1997 and 2017. Clinical response was assessed from clinical activity indices 12 weeks after starting treatment...
March 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29577038/searching-for-bacterial-biofilm-in-recurrent-cholangitis-in-primary-sclerosing-cholangitis-a-case-presentation-and-introduction-of-an-unexplored-disease-mechanism
#16
Alyssa Y Choi, Florencia Jalikis, Maria Westerhoff, Sarag Boukhar, Elinor Pulcini, Chris Damman, Lei Yu
Inflammation and fibrosis of the bile ducts are the defining pathological characteristics of primary sclerosing cholangitis (PSC). A previously unexplored mechanism for recurrent cholangitis, one of PSC's most common presentations, is bacterial colonization of the biliary epithelium in the form of biofilm, which may confer resistance to antibiotics and host phagocytic machinery. The aim of the current study was to assess whether bacteria could be seen on the liver explant and whether they organized in the form of biofilm...
March 28, 2018: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/29576223/gadolinium-based-relative-contrast-enhancement-in-primary-sclerosing-cholangitis-additional-benefit-for-clinicians
#17
S Keller, S K Venkatesh, M Avanesov, J M Weinrich, R Zenouzi, C Schramm, G Adam, J Yamamura
AIM: To evaluate the benefit of extracellular gadolinium-based contrast agent (GBCA) enhanced magnetic resonance imaging (MRI) in addition to conventional non-enhanced T2-weighted imaging (WI) for quantification of inflammatory or fibrotic alterations in the liver parenchyma of patients with primary sclerosing cholangitis (PSC). MATERIAL AND METHODS: MRI (3 T) examinations were reviewed retrospectively by two radiologists in 27 PSC patients (age 42.9±15.6 years), and 19 controls...
March 22, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29574971/design-and-endpoints-for-clinical-trials-in-primary-sclerosing-cholangitis
#18
REVIEW
Cyriel Y Ponsioen, Keith D Lindor, Ruby Mehta, Lara Dimick-Santos
Primary sclerosing cholangitis is a rare and chronic liver disease for which there is no effective therapy. There has been growing interest in developing treatments for this condition with several agents being proposed as potential therapies. However, there is lack of clarity about how to measure clinical benefit in trials in patients with this complex and rare disease. This article reviews regulatory information, the available literature on natural history, as well as potential candidate clinical and surrogate endpoints...
March 25, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29570558/clinical-remission-and-normalization-of-laboratory-studies-in-a-patient-with-ulcerative-colitis-and-primary-sclerosing-cholangitis-using-dietary-therapy
#19
David L Suskind, Bicong Wu, Kim Braly, M Cristina Pacheco, Ghassan Wahbeh, Dale Lee
No abstract text is available yet for this article.
March 22, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29567006/chromoendoscopy-versus-autofluorescence-imaging-for-neoplasia-detection-in-patients-with-longstanding-ulcerative-colitis-find-uc-an-international-multicentre-randomised-controlled-trial
#20
Jasper L A Vleugels, Matt D Rutter, Krish Ragunath, Colin J Rees, Cyriel Y Ponsioen, Conor Lahiff, Shara N Ket, Linda K Wanders, Sunil Samuel, Faheem Butt, Teaco Kuiper, Simon P L Travis, Geert D'Haens, Lai M Wang, Susanne van Eeden, James E East, Evelien Dekker
BACKGROUND: Patients with longstanding ulcerative colitis undergo regular dysplasia surveillance because they have an increased colorectal cancer risk. Autofluorescence imaging and chromoendoscopy improve dysplasia detection. The aim of this study was to determine whether autofluorescence imaging should be further studied as an alternative method for dysplasia surveillance in patients with longstanding ulcerative colitis. METHODS: This prospective, international, randomised controlled trial included patients from an ulcerative colitis-dysplasia surveillance cohort from five centres in the Netherlands and the UK...
March 19, 2018: Lancet. Gastroenterology & Hepatology
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