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https://www.readbyqxmd.com/read/29769222/transient-outward-k-current-i-to-underlies-the-right-ventricular-initiation-of-polymorphic-ventricular-tachycardia-in-a-transgenic-rabbit-model-of-long-qt-syndrome-type-1
#1
Bum-Rak Choi, Weiyan Li, Dmitry Terentyev, Anatoli Y Kabakov, Mingwang Zhong, Colin M Rees, Radmila Terentyeva, Tae Yun Kim, Zhilin Qu, Xuwen Peng, Alain Karma, Gideon Koren
BACKGROUND: Sudden death in long-QT syndrome type 1 (LQT1), an inherited disease caused by loss-of-function mutations in KCNQ1, is triggered by early afterdepolarizations (EADs) that initiate polymorphic ventricular tachycardia (pVT). We investigated ionic mechanisms that underlie pVT in LQT1 using a transgenic rabbit model of LQT1. METHODS: Optical mapping, cellular patch clamping, and computer modeling were used to elucidate the mechanisms of EADs in transgenic LQT1 rabbits...
June 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29765985/effects-of-afternoon-nap-deprivation-on-adult-habitual-nappers-inhibition-functions
#2
Qingwei Chen, Taotao Ru, Minqi Yang, Pei Yan, Jinghua Li, Ying Yao, Xiaoran Li, Guofu Zhou
Multiple studies have established the effects of afternoon naps on cognition. However, relatively few studies have investigated the domain of executive functions. Moreover, the effects of napping on inhibition are far from conclusive. The present study employed adult habitual nappers to investigate the effects of afternoon nap deprivation on response-based inhibition assessed by a Go/No-go task and stimulus-based inhibition assessed by a Flanker task and on alertness assessed by a psychomotor vigilance test (PVT) and the Karolinska Sleepiness Scale (KSS)...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29764618/investigating-daily-fatigue-scores-during-two-week-offshore-day-shifts
#3
Vanessa Riethmeister, Ute Bültmann, Marijke Gordijn, Sandra Brouwer, Michiel de Boer
OBJECTIVES: This study examined daily scores of fatigue and circadian rhythm markers over two-week offshore day shift periods. METHODS: A prospective cohort study among N = 60 offshore day-shift workers working two-week offshore shifts was conducted. Offshore day shifts lasted from 07:00 - 19:00 h. Fatigue was measured objectively with pre- and post-shift scores of the 3-minute psychomotor vigilance tasks (PVT-B) parameters (reaction times, number of lapses, errors and false starts) and subjectively with pre- and post-shift Karolinska Sleepiness Scale (KSS) ratings...
September 2018: Applied Ergonomics
https://www.readbyqxmd.com/read/29747524/congenital-thrombophilia-in-patients-with-superior-mesenteric-venous-thrombosis-or-portal-vein-thrombosis
#4
Ikejiri Makoto, Masanobu Usui, Hideo Wada, Takeshi Matsumoto, Kohshi Ohishi, Akihiro Shindo, Yoshiki Yamashita, Kaname Nakatani, Shigehisa Tamaki, Hidekazu Tomimoto, Shuji Isaji
We explored the relationship between abdominal vein thromboses, including portal vein thrombosis (PVT) and superior mesenteric vein thrombosis (SMVT), and thrombophilia. The frequency of thrombophilia, such as antithrombin (AT), protein C (PC), or protein S (PS) gene mutations, was examined in 21 patients with PVT, 6 patients with SMVT, and 6 patients with both PVT and SMVT. Low levels of AT, PC, or PS were frequently detected in patients with PVT or mesenteric vein thrombosis, and 4 mutations in the PS gene, 3 mutations in the PC gene, and 2 mutations in AT the gene were detected...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29738632/reversal-of-hypercoagulability-in-patients-with-hcv-related-cirrhosis-after-treatment-with-direct-acting-antivirals
#5
Francesco Paolo Russo, Alberto Zanetto, Elena Campello, Cristiana Bulato, Sarah Shalaby, Luca Spiezia, Sabrina Gavasso, Enrica Franceschet, Claudia Radu, Marco Senzolo, Patrizia Burra, Ton Lisman, Paolo Simioni
BACKGROUND AND AIMS: The long-term impact of sustained virological response (SVR) after direct-acting antivirals (DAAs) on the hypercoagulability associated with HCV cirrhosis is unknown. We longitudinally evaluated the effect of DAAs treatment on cirrhotic coagulopathy. METHODS: Pro- and anticoagulant factors levels and thrombin generation were assessed in patients with HCV-related cirrhosis at baseline, end of therapy (EOT), at 12, 24 and 48 weeks (W) after EOT...
May 8, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29723419/vein-resection-during-pancreaticoduodenectomy-for-pancreatic-adenocarcinoma-patency-rates-and-outcomes-associated-with-thrombosis
#6
Rebecca A Snyder, Laura R Prakash, Graciela M Nogueras-Gonzalez, Michael P Kim, Thomas A Aloia, Jean-Nicolas Vauthey, Jeffrey E Lee, Jason B Fleming, Matthew H G Katz, Ching-Wei D Tzeng
BACKGROUND AND OBJECTIVES: Venous patency rates after pancreaticoduodenectomy (PD) with portal vein (PV) resection are not well established, and the oncologic impact of portal vein thrombosis (PVT) is unknown. The primary aim of this study was to determine rates and predictors of PVT after PD with PV resection for pancreatic adenocarcinoma (PDAC). METHODS: A retrospective cohort study was performed on PDAC patients treated with preoperative therapy and PD with PV resection at a high-volume institution (2008-15)...
May 3, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29720857/portal-vein-thrombosis-in-cirrhosis-diagnosis-natural-history-and-therapeutic-challenges
#7
REVIEW
Aikaterini Mantaka, Aikaterini Augoustaki, Elias A Kouroumalis, Dimitrios N Samonakis
Portal vein thrombosis (PVT) is a frequent complication in cirrhosis and its prevalence increases with disease severity. Several factors are involved in the development and progression of PVT. The challenge for the management of PVT is the precise evaluation of the bleeding risk as opposed to life-threatening extension of thrombosis. Nevertheless, the impact on the progression and outcome of liver disease is unclear. A critical evaluation of the available data discloses that treating PVT in cirrhotics is safe and effective...
May 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29704907/illness-perceptions-predict-cognitive-performance-validity
#8
George K Henry, Robert L Heilbronner, Julie Suhr, Jeffrey Gornbein, Eveleigh Wagner, Daniel L Drane
OBJECTIVES: The aim of this study was to investigate the relationship of psychological variables to cognitive performance validity test (PVT) results in mixed forensic and nonforensic clinical samples. METHODS: Participants included 183 adults who underwent comprehensive neuropsychological examination. Criterion groups were formed, that is, Credible Group or Noncredible Group, based upon their performance on the Word Memory Test and other stand-alone and embedded PVT measures...
April 29, 2018: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29692563/a-comparative-evaluation-of-intraoral-and-extraoral-digital-impressions-an-in-vivo-study
#9
Gursharan Kaur Sason, Gaurang Mistry, Rubina Tabassum, Omkar Shetty
Aim: The accuracy of a dental impression is determined by two factors: "trueness" and "precision." The scanners used in dentistry are relatively new in market, and very few studies have compared the "precision" and "trueness" of intraoral scanner with the extraoral scanner. The aim of this study was to evaluate and compare accuracy of intraoral and extraoral digital impressions. Materials and Methods: Ten dentulous participants (male/female) aged 18-45 years with an asymptomatic endodontically treated mandibular first molars with adjacent teeth present were selected for this study...
April 2018: Journal of Indian Prosthodontic Society
https://www.readbyqxmd.com/read/29679703/pc-pvt-2-0-an-updated-platform-for-psychomotor-vigilance-task-testing-analysis-prediction-and-visualization
#10
Jaques Reifman, Kamal Kumar, Maxim Y Khitrov, Jianbo Liu, Sridhar Ramakrishnan
BACKGROUND: The psychomotor vigilance task (PVT) has been widely used to assess the effects of sleep deprivation on human neurobehavioral performance. To facilitate research in this field, we previously developed the PC-PVT, a freely available software system analogous to the "gold-standard" PVT-192 that, in addition to allowing for simple visual reaction time (RT) tests, also allows for near real-time PVT analysis, predictions, and visualization in a personal computer (PC)...
April 18, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29663585/perioperative-anticoagulation-practices-for-pediatric-liver-transplantation
#11
Stylianos Voulgarelis, Bernadette Vitola, Stacee M Lerret, Johnny C Hong, John P Scott
Despite continued advancements in perioperative care for pediatric liver transplant (LT), graft-threatening vascular occlusion events including hepatic artery thrombosis (HAT) and portal vein thrombosis (PVT) remain a source of significant morbidity and mortality. Perioperative anticoagulation is commonly used for the prevention of HAT and PVT, but evidence-based guidelines are lacking. The goals of this survey were to determine the frequency of use of an anticoagulation protocol and to describe variation in anticoagulation practices among pediatric LT centers...
April 16, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29661431/stratifying-mortality-in-a-model-for-end-stage-liver-disease-waiting-list-a-brazilian-single-center-study
#12
R B Martino, D R Waisberg, A P M Dias, V B S Inoue, R M Arantes, L B P Haddad, W Andraus, L D Lopes, F H F Galvão, A T W Song, L A C D'Albuquerque
BACKGROUND: The Model for End-Stage Liver Disease (MELD) system reliably predicts mortality in cirrhotic patients. However, the etiology of liver disease and presence of portal vein thrombosis are not directly taken into account in MELD score. Its impact on the outcomes of patients on the waiting list is still unclear. The aim of this study was to investigate mortality and access to transplantation regarding etiology of liver disease and portal vein thrombosis (PVT). METHODS: A total of 465 adult patients on the liver waiting list from August 2015 to August 2016 were followed up until August 2017...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29657612/deal-a-death-blow-hcc-in-cirrhotics-thrombotic-complications-their-frequency-characteristics-and-risk-factors
#13
Khalid Mahmood, Iftikhar Haider Naqvi, Aamer Mahmood, Syed Muhammad, Noor Muhammad
Introduction: The hepatocellular carcinoma (HCC), being the commonest primary cancer, holds the sixth slot in the list of common cancers worldwide. Thrombotic complications in the form of portal vein tumour thrombosis (PVTT) and bland portal vein thrombosis with HCC are common with a bad prognosis. Aim: The study aims to determine the demographic, clinical, and biochemical parameters of HCC patients. The study also compares the clinical and biochemical parameters among patients having HCC with and without thrombotic complication...
2018: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/29610596/catecholaminergic-polymorphic-ventricular-tachycardia-looking-to-the-future
#14
Andreea Elena Velcea, Calin Siliste, Dragos Vinereanu
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare inheritable cardiac disorder, characterized by polymorphic ventricular tachycardia (PVT) or bidirectional ventricular tachycardia, triggered by adrenergic stress, and manifested most frequently as syncope or sudden cardiac death. The disease has a heterogeneous genetic basis, with mutations in the genes encoding the ryanodine and calsequestrin channels accounting for the majority of cases. The diagnosis of CPVT is established in individuals with polymorphic ventricular premature beats, PVT or bidirectional ventricular tachycardia documented during exercise or adrenergic stress, who have a structurally normal heart and normal resting ECG...
December 2017: Mædica
https://www.readbyqxmd.com/read/29608637/nih-toolbox-picture-sequence-memory-test-for-assessing-clinical-memory-function-diagnostic-relationship-to-the-rey-auditory-verbal-learning-test
#15
David W Loring, Stephen C Bowden, Ekaterina Staikova, James A Bishop, Daniel L Drane, Felicia C Goldstein
Background: The NIH Cognitive Toolbox Picture Sequence Memory Test (PSMT) was developed as a measure of learning ability. PSMT use in clinical populations is only beginning to be investigated. Method: PSMT performance was analyzed in a retrospective series of 221 patients referred to either the Deep Brain Stimulation Clinic (n = 128) for presurgical evaluation, or to the Cognitive Screening Clinic (n = 93). Patients were also administered the Rey Verbal Auditory Verbal Learning test (AVLT)...
March 28, 2018: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29593928/extra-anatomic-jump-graft-from-the-right-colic-vein-a-novel-technique-to-manage-portal-vein-thrombosis-in-liver-transplantation
#16
Paolo Magistri, Giuseppe Tarantino, Tiziana Olivieri, Annarita Pecchi, Roberto Ballarin, Fabrizio Di Benedetto
Background: In the context of cirrhosis, portal vein thrombosis (PVT) is present in 2.1% to 26% of patients. PVT is no longer considered an absolute contraindication for liver transplantation, and nowadays, surgical strategies depend on the extent of PVT. Complete PVT is associated with higher morbidity rates and poor prognosis, while comparable long-term outcomes can be achieved as long as physiological portal inflow is restored. Materials and Methods: We report our experience with a 45-year-old patient undergoing liver transplant with a PVT (stage III-b)...
2018: Case Reports in Surgery
https://www.readbyqxmd.com/read/29590406/medical-evaluation-board-involvement-non-credible-cognitive-testing-and-emotional-response-bias-in-concussed-service-members
#17
Scott R Mooney, Jane Stafford, Elizabeth Seats
Introduction: Military Service Members (SMs) with post-concussive symptoms are commonly referred for further evaluation and possible treatment to Department of Defense Traumatic Brain Injury Clinics where neuropsychological screening/evaluations are being conducted. Understudied to date, the base rates of noncredible task engagement/performance validity testing (PVT) during cognitive screening/evaluations in military settings appears to be high. The current study objectives are to: (1) examine the base rates of noncredible PVTs of SMs undergoing routine clinical or Medical Evaluation Board (MEB) related workups using multiple objective performance-based indicators; (2) determine whether involvement in MEB is associated with PVT or symptom exaggeration/symptom validity testing (SVT) results; (3) elucidate which psychiatric symptoms are associated with noncredible PVT performances; and (4) determine whether MEB participation moderates the relationship between psychological symptom exaggeration and whether or not SM goes on to demonstrate PVTs failures - or vice versa...
March 26, 2018: Military Medicine
https://www.readbyqxmd.com/read/29584945/diffusivity-of-carbon-dioxide-in-aqueous-solutions-under-geologic-carbon-sequestration-conditions
#18
Pradeep N Perera, Hang Deng, P James Schuck, Benjamin Gilbert
Accurate assessment of the long-term security of geologic carbon sequestration requires knowledge of the mobility of carbon dioxide in brines under pressure and temperature conditions that prevails in subsurface aquifers. Here, we report Raman spectroscopic measurements of the rate of CO2 diffusion in water and brines as a function of pressure, salinity and the concentration of the CO2. In pure water at 50  2˚C and 90 ± 2 bar, we find that diffusion coefficient, D, to be 3.08 ± 0.03  10-9 m2/s, a value that is consistent with a recent microfluidic study but lower than earlier PVT measurements...
March 27, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29576865/hcc-with-low-and-normal-serum-alpha-fetoprotein-levels
#19
Brian I Carr, Hikmet Akkiz, Oguz Üsküdar, Kendal Yalçın, Vito Guerra, Sedef Kuran, Ümit Karaoğullarından, Engin Altıntaş, Ayşegül Özakyol, Salih Tokmak, Tuğsan Ballı, Mehmet Yücesoy, Halil İbrahim Bahçeci, Abdulalh Ülkü, Tolga Akçam, Kamil Yalçın Polat, Nazım Ekinci, Halis Şimşek, Necati Örmeci, Abdulalh Sonsuz, Mehmet Demir, Murat Kılıç, Ahmet Uygun, Ali Demir, Anıl Delik, Burcu Arslan, Figen Doran, Sezai Yilmaz, Yaman Tokat
A large database of 1773 HCC patients in Turkey was examined. 41.9% had alpha-fetoprotein (AFP) levels <20 IU/ml and an additional 16.123% had values between 20-100 IU/ml. This 58% of the cohort (<100 IU/ml AFP levels) was examined in detail. 66% of patients with small (<5 cm) HCCs had low AFP, compared to 49% of patients with larger (>5 cm) HCCs. The mean diameter (MTD) of larger MTD, low AFP tumors was 8.4cm. Therefore, factors other than AFP must contribute to HCC tumor growth. Larger tumors in low AFP patients had both higher platelet levels and increased PVT percent...
2018: Clinical Practice
https://www.readbyqxmd.com/read/29570480/evaluation-of-d-dimer-levels-in-patients-with-prosthetic-valve-thrombosis-relationship-with-thrombus-burden-and-cerebrovascular-events
#20
Sinan Cerşit, Sabahattin Gündüz, Emrah Bayam, Ahmet Güner, Semih Kalkan, Macit Kalçık, Süleyman Karakoyun, Mustafa Ozan Gürsoy, Mahmut Yesin, Özkan Candan, Mehmet Özkan
: Plasma D-dimer level is an indicator of thrombosis and endogenous fibrinolytic activity. We investigated the association between the D-dimer levels and thrombus burden and cerebrovascular events in patients with obstructive prosthetic valve thrombosis (PVT). This retrospective study included 47 patients with obstructive left-sided PVT and 32 controls in whom PVT was excluded with comprehensive transthoracic and transesophageal echocardiography (TEE). The patient group included 11 aortic, 27 mitral, and 9 aortic and mitral valve PVT patients and the control group included 2 aortic, 25 mitral, and 5 aortic and mitral valve patients...
March 22, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
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