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https://www.readbyqxmd.com/read/28728622/psychomotor-vigilance-test-and-its-association-with-daytime-sleepiness-and-inflammation-in-sleep-apnea-clinical-implications
#1
Yun Li, Alexandros Vgontzas, Ilia Kritikou, Julio Fernandez-Mendoza, Maria Basta, Slobodanka Pejovic, Jordan Gaines, Edward O Bixler
STUDY OBJECTIVES: Excessive daytime sleepiness (EDS) is a key symptom of obstructive sleep apnea (OSA). The Psychomotor Vigilance Task (PVT) has been suggested as an objective easy-to-use, inexpensive alternative to the Multiple Sleep Latency Test (MSLT) to measure EDS. In patients with OSA, physiological sleepiness, but not subjective EDS (Epworth Sleepiness Scale [ESS]), has been associated with increased levels of the sleep- inducing proinflammatory cytokine interleukin-6 (IL-6). The goal of this study was to assess the association of PVT with objectively measured sleepiness (MSLT) and subjectively measured sleepiness (ESS) and IL-6 levels in patients with OSA...
July 14, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28702574/electrogenerated-chemiluminescence-logic-gate-operations-based-on-molecule-responsive-organic-microwires
#2
Jianmin Gu, Jingxiao Wu, Yahui Gao, Tianhui Wu, Qing Li, Aixue Li, Jian-Yao Zheng, Bin Wen, Faming Gao
Complex logic gate operations using organic microwires as signal transducers based on electrogenerated chemiluminescence (ECL) intensity as the optical readout signal have been developed by taking advantage of the unique ECL reaction between organic semiconductor 9,10-bis(phenylethynyl)anthracene (BPEA) microwires and small molecules. The BPEA microwires, prepared on cleaned-ITO substrate using a simple physical vapor transport (PVT) method, were subsequently used for construction of the ECL sensors. The developed sensor exhibits high ECL efficiency and excellent stability in the presence of co-reactant tripropylamine...
July 12, 2017: Nanoscale
https://www.readbyqxmd.com/read/28697776/exposure-to-blue-light-during-lunch-break-effects-on-autonomic-arousal-and-behavioral-alertness
#3
Emi Yuda, Hiroki Ogasawara, Yutaka Yoshida, Junichiro Hayano
BACKGROUND: Exposures to melanopsin-stimulating (melanopic) component-rich blue light enhance arousal level. We examined their effects in office workers. Eight healthy university office workers were exposed to blue and orange lights for 30 min during lunch break on different days. We compared the effects of light color on autonomic arousal level assessed by heart rate variability (HRV) and behavioral alertness by psychomotor vigilance tests (PVT). Heart rate was higher and high-frequency (HF, 0...
July 11, 2017: Journal of Physiological Anthropology
https://www.readbyqxmd.com/read/28696772/enhanced-detection-of-feigned-cognitive-impairment-using-per-item-response-time-measurements-in-the-word-memory-test
#4
T Lupu, T Elbaum, M Wagner, Y Braw
Response time (RT) is a less obvious outcome measure than conventional accuracy measures used in performance validity tests (PVTs). It is also under less conscious control and is affected by cognitive processes associated with deception. Studies that assessed the utility of RT for the detection of feigned cognitive impairment are however numbered. Moreover, RT variability was not assessed in a clinically used PVT. In the current study, we assessed the utility of RT measures for the detection of feigned cognitive impairment in the Word Memory Test (WMT)...
July 11, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/28695316/interobserver-variability-in-target-volume-delineation-of-hepatocellular-carcinoma-an-analysis-of-the-working-group-stereotactic-radiotherapy-of-the-german-society-for-radiation-oncology-degro
#5
E Gkika, S Tanadini-Lang, S Kirste, P A Holzner, H P Neeff, H C Rischke, T Reese, F Lohaus, M N Duma, K Dieckmann, R Semrau, M Stockinger, D Imhoff, N Kremers, M F Häfner, N Andratschke, U Nestle, A L Grosu, M Guckenberger, T B Brunner
BACKGROUND: Definition of gross tumor volume (GTV) in hepatocellular carcinoma (HCC) requires dedicated imaging in multiple contrast medium phases. The aim of this study was to evaluate the interobserver agreement (IOA) in gross tumor delineation of HCC in a multicenter panel. METHODS: The analysis was performed within the "Stereotactic Radiotherapy" working group of the German Society for Radiation Oncology (DEGRO). The GTVs of three anonymized HCC cases were delineated by 16 physicians from nine centers using multiphasic CT scans...
July 10, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28692008/use-of-the-psychomotor-vigilance-test-in-fitness-for-work-assessments
#6
Steven Lerman, Daniel Mollicone, Sara Coats
OBJECTIVE: The objective of the pilot program was to evaluate the utility of the psychomotor vigilance test (PVT) in aiding clinicians in making fitness for work determinations. METHODS: A 10-minute PVT was incorporated into fitness for work examinations by occupational health staff at two integrated refining/petrochemical plants. Based on all evidence from the clinical examination, including PVT results, clinicians made their fitness for work determination. RESULTS: Employees who were determined to be fit for work had significantly fewer PVT errors than did employees determined to be unfit for work or fit for work with limitations, with t(98) = -14...
July 6, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28682164/association-of-nonmalignant-portal-vein-thrombosis-and-outcomes-after-transjugular-intrahepatic-portosystemic-shunt-in-patients-with-cirrhosis
#7
Yong Lv, Chuangye He, Zhengyu Wang, Wengang Guo, Jianhong Wang, Wei Bai, Lei Zhang, Qiuhe Wang, Haibo Liu, Bohan Luo, Jing Niu, Kai Li, Jun Tie, Zhanxin Yin, Daiming Fan, Guohong Han
Purpose To assess the effects of preexisting nonmalignant portal vein thrombosis (PVT) on mortality, clinical relapse, shunt dysfunction, and overt hepatic encephalopathy (HE) after transjugular intrahepatic portosystemic shunt (TIPS) placement. Materials and Methods This retrospective study was approved by the institutional ethics committee, and written informed consent was obtained from all patients. From March 2001 to December 2014, 1171 consecutive patients with cirrhosis (762 men, 409 women; mean age, 50...
July 5, 2017: Radiology
https://www.readbyqxmd.com/read/28666312/antithrombin-iii-administration-for-portal-vein-thrombosis-in-patients-with-liver-disease-a-randomized-double-blind-controlled-trial
#8
Hisashi Hidaka, Shigehiro Kokubu, Takahiro Sato, Shinji Katsushima, Namiki Izumi, Takumi Igura, Shingo Asahara, Kazuo Notsumata, Yukio Osaki, Keiji Tsuji, Hirofumi Kawanaka, Tomohiko Akahoshi, Shozo Hirota, Shoichi Matsutani
AIM: Portal vein thrombosis (PVT) is one of the most critical disorders in liver disease patients. These patients have the imbalance of coagulation and coagulation inhibition resulting from decreased levels of coagulation inhibitory factors, such as protein C, protein S, and antithrombin III (AT-III). We designed this randomized, double-blind, placebo-controlled trial comparing the safety and efficacy of AT-III administration for PVT in patients with those who received no treatment. METHODS: Eligible patients were diagnosed with the association of thrombus, without tumor thrombus, thrombus in more than 50% of the cross-sectional lumen of the portal vein...
June 30, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28658826/analysis-of-12-months-clinical-outcomes-associated-with-implantation-of-ultrathin-60-%C3%AE-m-bare-metal-stent-in-an-unselected-real-world-population-with-coronary-artery-disease
#9
Adikesava Naidu Otikunta, Uday Kumar Hosad, Y V Subba Reddy, Srikanth Eruvaram, Ravi Srinivas, Rajeev Garg, Limmy Loret Lobo
INTRODUCTION: In the era of drug-eluting stents, Bare Metal Stent (BMS) has worked its way up to be recognized in several indications. Moreover, literature suggests that strut thickness has been directly related to the restenosis rate. AIM: We intended to evaluate the clinical performance of the ultrathin (60 μm) Flexinnium stent (Sahajanand Medical Technologies Pvt. Ltd. Surat, India) for treatment of a wide range of patients with coronary artery disease in routine clinical practice...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28658800/a-post-marketing-surveillance-study-to-evaluate-performance-of-the-eximo%C3%A2-blood-glucose-monitoring-system
#10
Sonia R Chandnani, C D Ramakrishna, Bhargav A Dave, Pankaj S Kothavade, Ashok S Thakkar
INTRODUCTION: The performance of Blood Glucose Monitoring System (BGMS) is critical as the information provided by the system guide the patient or health care professional in making treatment decisions. However, besides evaluating accuracy of the BGMS in laboratory setting, it is equally important that the intended users (healthcare professionals and patients) should be able to achieve blood glucose measurements with similar level of high accuracy. AIM: To assess the performance of EXIMO™ (Meril Diagnostics Pvt...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28656790/the-dot-counting-test-adds-up-validation-and-response-pattern-analysis-in-a-mixed-clinical-veteran-sample
#11
Jason R Soble, Octavio A Santos, Kathleen M Bain, Joshua W Kirton, K Chase Bailey, Edan A Critchfield, Justin J F O'Rourke, Jonathan M Highsmith, David Andrés González
OBJECTIVE: This study cross-validated the Dot Counting Test (DCT) as a performance validity test (PVT) among a mixed clinical veteran sample. Completion time and error patterns also were examined by validity group and cognitive impairment status. METHOD: This cross-sectional study included 77 veterans who completed the DCT during clinical evaluation. Seventy-four percent (N = 57) were classified as valid and 26% as noncredible (N = 20) via the Word Memory Test (WMT) and Test of Memory Malingering (TOMM)...
June 28, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28633200/complete-response-of-advanced-hepatocellular-carcinoma-to-sorafenib-another-case-and-a-comprehensive-review
#12
Tae Suk Kim, Ji Hoon Kim, Baek Hui Kim, Young-Sun Lee, Yang Jae Yoo, Seong Hee Kang, Sang-June Suh, Young Kul Jung, Yeon Seok Seo, Hyung Joon Yim, Jong Eun Yeon, Kwan Soo Byun
Since sorafenib was introduced in 2007 for treating advanced hepatocellular carcinoma (HCC), 15 patients have achieved a complete response (CR) in advanced HCC. However, only four of these reports can be regarded as real CRs involving adequate assessments including imaging, serum tumor markers, and histologic examinations of completely resected specimens. A 54-year-old man with hepatitis C virus (HCV)-related liver cirrhosis (LC) presented to our unit. A CT scan demonstrated a 3.8-cm arterial hypervascular/portal-washout mass in the right lobe and invasion in the right portal vein...
June 20, 2017: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/28632958/decreased-portal-vein-velocity-is-predictive-of-the-development-of-portal-vein-thrombosis-a-matched-case-control-study
#13
Jonathan G Stine, Jennifer Wang, Puja M Shah, Curtis K Argo, Nicolas Intagliata, Andre Uflacker, Stephen H Caldwell, Patrick G Northup
BACKGROUND & AIMS: Portal vein thrombosis (PVT) in cirrhosis may lead to hepatic decompensation and increased mortality. We aimed to investigate if decreased portal vein (PV) velocity is associated with future PVT. METHODS: Data on adult patients with cirrhosis and PVT between January 1, 2005 and July 30, 2015 were obtained. Cases with PVT were matched by age, gender and Model for End stage Liver Disease (MELD) score to corresponding controls without PVT. Cox proportional hazards models, receiver operator curves and Kaplan Meier curves were constructed...
June 20, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28632024/performance-validity-testing-in-a-clinical-sample-of-adults-with-sickle-cell-disease
#14
Katherine E Dorociak, Evan T Schulze, Lauren E Piper, Robert E Molokie, Julie K Janecek
OBJECTIVE: Neuropsychologists utilize performance validity tests (PVTs) as objective means for drawing inferences about performance validity. The Test of Memory Malingering (TOMM) is a well-validated, stand-alone PVT and the Reliable Digit Span (RDS) and Reliable Digit Span-Revised (RDS-R) from the Digit Span subtest of the WAIS-IV are commonly employed, embedded PVTs. While research has demonstrated the utility of these PVTs with various clinical samples, no research has investigated their use in adults with sickle cell disease (SCD), a condition associated with multiple neurological, physical, and psychiatric symptoms...
June 15, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28627922/inconsistent-responding-on-the-mmpi-2-rf-and-uncooperative-attitude-evidence-from-cognitive-performance-validity-measures
#15
Roger O Gervais, Anthony M Tarescavage, Manfred F Greiffenstein, Dustin B Wygant, Cheryl Deslauriers, Patricia Arends
It is generally well understood that possible reasons for inconsistent responding on the Minnesota Multiphasic Personality Inventory-2 Restructured Form (MMPI-2-RF), as measured by the Variable Response Inconsistency (VRIN-r) and True Response Inconsistency (TRIN-r) scales, include reading or language limitations, cognitive impairment, and intentional random responding; however, the interpretive recommendations for the test suggest that higher scores on these scales can also result from an uncooperative test-taking approach...
June 19, 2017: Psychological Assessment
https://www.readbyqxmd.com/read/28626269/the-addition-of-amphetamine-to-potentially-sedating-medication-regimens-an-exploratory-investigation-of-the-impact-upon-reaction-time-and-sustained-attention
#16
James W Price
OBJECTIVES: The addition of amphetamine to a sedating medication may reduce sedation but does it augment reaction time and sustained attention for workers? The purpose of this exploratory study was gain insight into between group differences that would assist hypothesis formation for a subsequent hypothesis testing study. METHODS: This study examined psychomotor vigilance task (PVT) performance for a group taking potentially sedating medications (opiates, benzodiazepines, anticholinergics, barbiturates or polypharmacy) while taking amphetamine to a group not taking amphetamine...
May 15, 2017: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/28617092/determination-of-the-smoking-gun-of-intent-significance-testing-of-forced-choice-results-in-social-security-claimants
#17
Laurence M Binder, Michael D Chafetz
OBJECTIVE: Significantly below-chance findings on forced choice tests have been described as revealing "the smoking gun of intent" that proved malingering. The issues of probability levels, one-tailed vs. two-tailed tests, and the combining of PVT scores on significantly below-chance findings were addressed in a previous study, with a recommendation of a probability level of .20 to test the significance of below-chance results. The purpose of the present study was to determine the rate of below-chance findings in a Social Security Disability claimant sample using the previous recommendations...
June 15, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28611269/the-role-of-tips-in-patients-with-refractory-ascites-and-portal-vein-thrombosis
#18
Paulina Chinchilla-López, Nashla Hamdan-Pérez, Jorge Guerrero-Ixtlahuac, Beatriz Barranco-Fragoso, Nahum Méndez-Sánchez
Nowadays the contraindication for Transjugular intrahepatic portosystemic shunt (TIPS) in patients with portal vein thrombosis (PVT) had been modify. The experience and technology have reduce the complications for this procedure. We report a case of refractory ascites and portal vein thrombosis to emphasize the role of TIPS in the treatment for this condition.
August 1, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28611261/non-neoplastic-portal-vein-thrombosis-in-hcv-cirrhosis-patients-is-it-an-immuno-inflammatory-disorder
#19
Mona Abu El-Makarem, Atef El-Akad, Moustafa Elian, Tahra Sherif, Ragaa El-Shaheed, Aliaa Abd El Fatah, Douaa Sayed, Rania Bakry, Aisha Mahmoud
BACKGROUND AND AIMS: Portal vein thrombosis (PVT) is a critical complication in cirrhotic patients. We explored the role of the activated factor VII-antithrombin (FVIIa-AT) complex and enhanced monocytic tissue factor (TF) expression in the development and prediction of non-neoplastic PVT in cirrhotic patients. MATERIAL AND METHODS: A total of 30 HCV-cirrhosis patients were included in our study. They were compared to 35 cirrhotic patients without PVT, 15 non-cirrhotic patients with PVT, and 15 healthy controls...
August 1, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28606656/divergent-antiarrhythmic-effects-of-resveratrol-and-piceatannol-in-a-whole-heart-model-of-long-qt-syndrome
#20
Christian Ellermann, Julian Wolfes, Simon Kochhäuser, Dirk G Dechering, Florian Reinke, Kristina Wasmer, Lars Eckardt, Gerrit Frommeyer
BACKGROUND: The polyphenol resveratrol and its metabolite piceatannol have beneficial health effects including antiarrhythmic properties in ischemia/reperfusion. The objective of this study was to determine potential antiarrhythmic effects in acquired long-QT-syndrome (LQTS). METHODS AND RESULTS: 26 rabbit hearts were isolated and Langendorff-perfused. The IKr-blocker sotalol (100μM) was infused to mimic LQTS-2. Hearts were assigned to two groups. Sotalol significantly prolonged action potential duration (APD90) and QT-interval in both groups (group 1:APD90: +18ms, p<0...
June 3, 2017: International Journal of Cardiology
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