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https://www.readbyqxmd.com/read/28070621/behavioral-evidence-for-the-abuse-potential-of-the-novel-synthetic-cathinone-alpha-pyrrolidinopentiothiophenone-pvt-in-rodents
#1
Jae Hoon Cheong, Mee Jung Choi, Choon-Gon Jang, Yong Sup Lee, Sooyeun Lee, Hee Jin Kim, Joung-Wook Seo, Seong Shoon Yoon
RATIONALE: Synthetic cathinones are chemical derivatives of cathinone that are pharmacologically similar to cocaine and methamphetamine. Recently, abuse of synthetic cathinones among young people has increased. OBJECTIVES: The present study aimed to characterize the behavioral effects of alpha-pyrrolidinopentiothiophenone (PVT), an analog of alpha-pyrrolidinovalerophenone and second-generation synthetic cathinone, as well as to evaluate its abuse potential, using conditioned place preference, intravenous self-administration (SA), and drug discrimination paradigms in rodent models...
January 9, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28062433/rivaroxaban-lessens-the-number-of-thrombi-in-the-left-atrium-and-right-lower-pulmonary-vein-as-illustrated-by-transoesophageal-echocardiography-but-not-80-mdct
#2
Hidekazu Takeuchi
Stroke is a clinically important problem. A left atrial thrombus is known as a cause of ischaemic stroke. A pulmonary vein thrombus (PVT) is thought to be rare; however, PVT is common in elderly patients. Additionally, images of PVT with transoesophageal echocardiography (TEE) following treatment have not been well contrasted with that from either 64 or 80-slice multidetector CT (80-MDCT). The images of such changes depicted by TEE remain unknown. An 87-year-old man with hypertension was examined by 80-MDCT and TEE to check the cardiac thrombus...
January 6, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28060276/the-rodent-psychomotor-vigilance-test-rpvt-a-method-for-assessing-neurobehavioral-performance-in-rats-and-mice
#3
Catherine M Davis, Peter G Roma, Robert D Hienz
The human Psychomotor Vigilance Test (PVT) is a widely used procedure for measuring changes in fatigue and sustained attention. The present article describes a rodent version of the PVT-termed the "rPVT"-that measures similar aspects of attention (i.e., performance accuracy, motor speed, premature responding, and lapses in attention). Data are presented that demonstrate both the short- and long-term usefulness of the rPVT when employed with laboratory rats. Rats easily learn the rPVT, and learning to perform the basic procedure takes less than two weeks of training...
December 29, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28050429/redo-mitral-valve-replacement-for-prosthetic-valve-thrombosis-single-center-experience
#4
Jignesh Kothari, Kartik Patel, Bhavin Brahmbhatt, Kinnaresh Baria, Malkesh Talsaria, Sanjay Patel, Sandeep Tailor
INTRODUCTION: Prosthetic Valve Thrombosis (PVT) remains a significant cause of morbidity and mortality after valve replacement. Although surgical treatment is usually preferred as life-saving in cases of obstructive PVT, optimal treatment is yet to be decided. AIM: To evaluate risk factors and outcome of the patients undergoing redo mitral valve surgery for acute PVT. MATERIALS AND METHODS: Between January 2012 and February 2015, 65 patients underwent redo surgery for obstructive PVT of mitral valve in Department of Cardiothoracic Surgery, UN Mehta Institute of Cardiology & Research Centre...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28050362/bio-medical-waste-managment-in-a-tertiary-care-hospital-an-overview
#5
Anita Pandey, Sanjiv Ahuja, Molly Madan, Ajay Kumar Asthana
INTRODUCTION: Bio-Medical Waste (BMW) management is of utmost importance as its improper management poses serious threat to health care workers, waste handlers, patients, care givers, community and finally the environment. Simultaneously, the health care providers should know the quantity of waste generated in their facility and try to reduce the waste generation in day-to-day work because lesser amount of BMW means a lesser burden on waste disposal work and cost saving. AIM: To have an overview of management of BMW in a tertiary care teaching hospital so that effective interventions and implementations can be carried out for better outcome...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28046359/th-cd-201-03-a-real-time-method-to-simultaneously-measure-linear-energy-transfer-and-dose-for-proton-therapy-using-organic-scintillators
#6
F Alsanea, F Therriault-Proulx, G Sawakuchi, S Beddar
PURPOSE: The light generated in organic scintillators depends on both the radiation dose and the linear energy transfer (LET). The LET dependence leads to an under-response of the detector in the Bragg peak of proton beams. This phenomenon, called ionization quenching, must be corrected to obtain accurate dose measurements of proton beams. This work exploits the ionization quenching phenomenon to provide a method of measuring LET and auto correcting quenching. METHODS: We exposed simultaneously four different organic scintillators (BCF-12, PMMA, PVT, and LSD; 1mm in diameter) and a plane parallel ionization chamber in passively scattered proton beams to doses between 32 and 43 cGy and fluence averaged LET values from 0...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28035764/alpha-pvp-as-an-active-component-of-herbal-highs-in-poland-between-2013-2015
#7
Bogumiła Byrska, Roman Stanaszek, Dariusz Zuba
Alpha-PVP (alpha-pyrrolidinovalerophenone, α-PVP) is a synthetic derivative of cathinone. It has been one of the most frequently detected new psychoactive substances (NPS) available on the drug market in recent years in Poland. The usual routes of administration of the drug include oral, insufflation, injection. Unexpectedly, we dealt with a great number of herbal samples that turned out to contain α-PVP. A total number of 352 herbal samples from 19 cases, in which we detected synthetic cathinones, were investigated in the Institute of Forensic Research (IFR) from 2013 to 2015...
December 30, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28031667/progression-of-thrombus-in-portal-vein-superior-mesenteric-vein-and-splenic-vein-even-on-anticoagulation-in-a-patient-with-ascending-colonic-malignancy-with-liver-metastasis-portal-vein-thrombosis-versus-portal-vein-tumor-thrombosis
#8
Ashish Sule, Annamarie Borja, Tay Jam Chin
Portal vein thrombosis (PVT) in a setting of liver metastasis is not easy to treat as it may be portal vein tumor thrombus (PVTT). A 77-year-old male patient was diagnosed as ascending colon carcinoma, underwent right hemicolectomy in 1991 with a recurrence in July 2009. In August 2009, he underwent computed tomography (CT) scan of the abdomen which showed evidence of superior mesenteric vein thrombosis with no liver metastasis. He was started with anticoagulation and decision was to treat long term. He was admitted with mesenteric artery ischemic symptoms in February 2012 on anticoagulation...
December 2016: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/28031666/thrombus-resolution-in-two-patients-with-portal-vein-thrombosis-without-anticoagulation-do-we-need-to-anticoagulate-patients-with-portal-vein-thrombosis
#9
Annamarie Borja, Weili Xing, Edwin Lymen, Benedict Azucena, Ashish Anil Sule
Portal vein thrombosis (PVT) is a thrombosis that develops in the trunk of the portal vein which can extend to its branches. It results from a combination of local and systemic prothrombotic factors. Anticoagulation is generally considered in PVT patients as long as the risk of bleeding is low. Limited data have been published regarding spontaneous resolution of PVT. We describe two cases of asymptomatic PVT who were not given anticoagulation in view of several factors, who, on repeat scans, showed resolution of their thrombus...
December 2016: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/28007356/the-aasm-2012-recommended-hypopnea-criteria-increase-the-incidence-of-obstructive-sleep-apnea-but-not-the-proportion-of-positional-obstructive-sleep-apnea
#10
Brett Duce, Antti Kulkas, Christian Langton, Juha Töyräs, Craig Hukins
OBJECTIVE/BACKGROUND: This study compared the effects of using the 2007 and 2012 American Academy of Sleep Medicine (AASM) recommended hypopnea criteria on the proportion of positional obstructive sleep apnea (pOSA). The effect of modifying the minimum recording time in each sleeping position on the proportion of pOSA was also investigated. PATIENTS/METHODS: 207 of 303 consecutive patients (91 of 207 were female) participated in polysomnography (PSG) for the suspicion of OSA met the inclusion criteria for this retrospective investigation...
October 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27983728/safety-and-acceptability-of-an-organic-light-emitting-diode-sleep-mask-as-a-potential-therapy-for-retinal-disease
#11
J N Sahni, G Czanner, T Gutu, S A Taylor, K M Bennett, S M Wuerger, I Grierson, C Murray-Dunning, M N Holland, S P Harding
PurposeThe purpose of the study was to study the effect of an organic light-emitting diode sleep mask on daytime alertness, wellbeing, and retinal structure/function in healthy volunteers and in diabetic macular oedema (DMO).Patients and methodsHealthy volunteers in two groups, 18-30 yrs (A), 50-70 yrs (B) and people with DMO (C) wore masks (504 nm wavelength; 80 cd/m(2) luminance; ≤8 h) nightly for 3 months followed by a 1-month recovery period. Changes from baseline were measured for (means): psychomotor vigilance task (PVT) (number of lapses (NL), response time (RT)), sleep, depression, psychological wellbeing (PW), visual acuity, contrast sensitivity, colour, electrophysiology, microperimetry, and retinal thickness on OCT...
December 16, 2016: Eye
https://www.readbyqxmd.com/read/27976349/activity-of-selected-west-african-medicinal-plants-against-mycobacterium-ulcerans-disease
#12
Pvt Fokou, A A Kissi-Twum, D Yeboah-Manu, R Appiah-Oppong, P Addo, Lrt Yamthe, A N Mfopa, F F Boyom, A K Nyarko
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27957255/pulmonary-vein-thrombosis-in-a-patient-with-polycythemia-vera
#13
Bhaskar Bhardwaj, Dany Jacob, Amit Sharma, Mouhanna Abu Ghanimeh, Paramdeep Baweja
Pulmonary vein thrombosis (PVT) is a rarely encountered disease entity with varied clinical presentations. It is usually associated with lung carcinoma, lung surgeries and as a complication of the radiofrequency catheter ablation procedure for atrial fibrillation. Its clinical manifestations can vary from mild hemoptysis to lung infarction with hemodynamic compromise. A 76-year-old male presented with a 2-d history of pleuritic left sided chest pain. His past medical history included polycythemia vera, atrial fibrillation, coronary artery disease, pulmonary embolism and pulmonary hypertension...
November 26, 2016: World Journal of Cardiology
https://www.readbyqxmd.com/read/27932178/extra-anatomical-meso-portal-venous-jump-graft-repair-for-early-portal-vein-thrombosis-after-liver-transplant-in-an-infant-with-a-hypoplastic-portal-vein-a-case-report
#14
R Matsumoto, K Uchida, S Nishida, E R Island, D M Levi, J Fan, A Tekin, G Selvaggi, A G Tzakis
BACKGROUND AND PURPOSE: Small infants with biliary atresia and hypoplastic portal veins (PV) are at risk for portal vein thrombosis (PVT) after liver transplantation (LT), which can lead to graft loss and mortality. Extra-anatomical PV reconstruction techniques have been established for adult cases of PVT; however, they have not been widely accepted for infants. METHODS: Here, we report the successful use of an extra-anatomical meso-portal venous jump graft to treat early PVT after LT in a 6-month-old infant with biliary atresia and PV hypoplasia...
November 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27930543/left-branch-of-portal-vein-thrombosis-in-a-liver-transplant-recipient-with-donation-after-cardiac-death-donor-a-case-report
#15
Maogen Chen, Weiqiang Ju, Xiaohong Lin, Qiang Zhao, Dongping Wang, Xiaoshun He
INTRODUCTION: Portal vein thrombosis (PVT) is one of the most severe complications after liver transplantation, which usually causes graft loss and recipient mortality. The founding of the embolic branch of portal system and its result are not well described in the literature. CLINICAL FINDINGS AND DIAGNOSES: We report here an unusual case of complete right branch thrombosis of portal vein after orthotopic liver transplantation from a donation after cardiac death donor, without obvious malaise...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27894839/relationship-of-p3b-single-trial-latencies-and-response-times-in-one-two-and-three-stimulus-oddball-tasks
#16
Matthew M Walsh, Glenn Gunzelmann, John R Anderson
The P300 is one of the most widely studied components of the human event-related potential. According to a longstanding view, the P300, and particularly its posterior subcomponent (i.e., the P3b), is driven by stimulus categorization. Whether the P3b relates to tactical processes involved in immediate responding or strategic processes that affect future behavior remains controversial, however. It is difficult to determine whether variability in P3b latencies relates to variability in response times because of limitations in the methods currently available to quantify the latency of the P3b during single trials...
November 25, 2016: Biological Psychology
https://www.readbyqxmd.com/read/27893491/role-of-low-molecular-weight-heparins-in-prevention-of-thromboembolic-complication-after-transarterial-chemoembolization-in-hepatocellular-carcinoma
#17
Osama Negm, Sabry Abou Saif, Mohamed El Gharib, Mohamed Yousef, Sherief Abd-Elsalam
BACKGROUND AND AIM: Portal vein thrombosis (PVT) is a common complication after transarterial chemoembolization (TACE) in hepatocellular carcinoma (HCC). This is the first clinical study to evaluate the role of low-molecular-weight heparins (LMWHs) with TACE in HCC for the prevention of thromboembolism complications (PVT). PATIENTS AND METHODS: This study was carried out on 40 patients with HCC requiring TACE who presented to the Tropical Medicine Department, Tanta University and Interventional Radiology Department of Ain-Shams University Hospitals starting from April 2015...
November 23, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27890896/interventional-treatment-of-severe-portal-vein-thrombosis-after-living-donor-liver-transplantation
#18
Youichi Kawano, Satoru Murata, Nobuhiko Taniai, Masato Yoshioka, Atsushi Hirakata, Yoshiaki Mizuguchi, Tetsuya Shimizu, Tomohiro Kanda, Junji Ueda, Hideyuki Takada, Hiroshi Yoshida, Koho Akimaru, Shiro Onozawa, Shinichirou Kumita, Eiji Uchida
Portal vein thrombosis (PVT) is a rare complication of liver transplantation which can lead to graft failure and patient death. Treatment can be difficult, especially in cases of PVT from the intrahepatic portal vein to the proximal jejunal veins. A 55-year-old woman had undergone living-donor liver transplantation with splenectomy for end-stage liver cirrhosis due to hepatitis C with hepatocellular carcinoma. Ten months after transplantation, massive ascites and slight abdominal pain developed, and computed tomography revealed a PVT between the intrahepatic portal vein and the superior mesenteric vein...
2016: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/27880998/recurrent-acute-portal-vein-thrombosis-in-liver-cirrhosis-treated-by-rivaroxaban
#19
Hyeyoung Yang, Seo Ree Kim, Myeong Jun Song
Cirrhosis can occur with the development of portal vein thrombosis (PVT). PVT may aggravate portal hypertension, and it can lead to hepatic decompensation. The international guideline recommends for anticoagulation treatment to be maintained for at least 3 months in all patients with acute PVT. Low-molecular-weight-heparin and changing to warfarin is the usual anticoagulation treatment. However, warfarin therapy is problematic due to a narrow therapeutic window and the requirement for frequent dose adjustment, which has prompted the development of novel oral anticoagulants for overcoming these problems...
December 2016: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/27880991/vascular-complications-in-living-donor-liver-transplantation-at-a-high-volume-centre-evolving-protocols-and-trends-observed-over-10-years
#20
A R Shiraz, M A Nayeem, S Agarwal, N Goyal, S Gupta
Vascular complications continue to have devastating effect; although their nature, incidence and outcome might have actually changed with increasing experience and proficiency in high volume centers. Aim was to analyze the trends observed in vascular complications with changing protocols in adult and pediatric- living donor liver transplantation (A-LDLT and P-LDLT) over 10 years in two time frames in terms of nature, incidence and outcome. It is a retrospective analysis of 391 (Group I= Jan. 2006- Dec.2010) and 741 (Group II= Jan...
November 23, 2016: Liver Transplantation
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