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https://www.readbyqxmd.com/read/28811669/paraventricular-thalamic-control-of-food-intake-and-reward-role-of-glucagon-like-peptide-1-receptor-signaling
#1
Zhi Yi Ong, Jing-Jing Liu, Zhiping P Pang, Harvey J Grill
Paraventricular thalamic nucleus (PVT) neurons receive hindbrain and hypothalamic inputs, and project to forebrain sites involved in reward and motivation function. The role of PVT in energy balance and reward control is however understudied. Given that PVT neurons express glucagon-like peptide-1 receptors (GLP-1R), which are critical to feeding and body weight control, we tested the hypothesis that PVT GLP-1R signaling contributes to food intake and reward inhibition. To assess the hypothesis, behavioral tests including chow and high-fat diet intake, meal patterns, conditioned place preference for high-fat food, cue-induced reinstatement of sucrose-seeking, and motivation to work for sucrose were employed following intra-PVT delivery of either GLP-1R agonist, exendin-4 (Ex4), or GLP-1R antagonist, exendin-9-39 (Ex9)...
July 19, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28808850/non-rem-sleep-disordered-breathing-affects-performance-on-the-psychomotor-vigilance-task
#2
Takuro Kitamura, Soichiro Miyazaki, Hiroshi Kadotani, Takashi Kanemura, Harun Bin Sulaiman, Shoko Takeuchi, Takahisa Tabata, Hideaki Suzuki
PURPOSE: Although many studies have investigated the clinical importance of sleep apnea on rapid eye movement (REM) and non-REM (NREM) sleep, the relationship between behavioral performance and apneic events during different sleep phases remains unclear. In the present study, we sought to investigate the effect of sleep phase fragmentation due to sleep-disordered breathing (SDB) during REM and NREM on the vigilance and sustainability of attention based on psychomotor vigilance task (PVT) performance...
August 14, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28803119/the-effects-of-low-intensity-cycling-on-cognitive-performance-following-sleep-deprivation
#3
Alexis B Slutsky, Jed A Diekfuss, James A Janssen, Nate T Berry, Chia-Hao Shih, Louisa D Raisbeck, Laurie Wideman, Jennifer L Etnier
This study examined the effect of 24h of sleep deprivation on cognitive performance and assessed the effect of acute exercise on cognitive performance following sleep deprivation. Young, active, healthy adults (n=24, 14 males) were randomized to control (age=24.7±3.7years, BMI=27.2±7.0) or exercise (age=25.3±3.3years, BMI=25.6±5.1) groups. Cognitive testing included a 5-min psychomotor vigilance task (PVT), three memory tasks with increasing cognitive load, and performance of the PVT a second time. On morning one, cognitive testing followed a typical night's sleep...
August 9, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28782143/dynamics-of-cerebral-responses-to-sustained-attention-performance-during-one-night-of-sleep-deprivation
#4
Yuanqiang Zhu, Yibin Xi, Ningbo Fei, Yuchen Liu, Xinxin Zhang, Lin Liu, Ziliang Xu, Jinbo Sun, Xuejuan Yang, Hong Yin, Jie Tian, Wei Qin
Total sleep deprivation (TSD) is increasingly common in modern society bringing various neurobehavioural effects. Dynamic changes of behaviour performances during TSD have been reported extensively, while the cerebral activation underlying such changes have not been elucidated clearly. This study aimed to investigate dynamic changes in cerebral responses to the fastest and slowest psychomotor vigilance task (PVT) trials during TSD. Thirty-six healthy subjects with intermediate chronotype performed the PVT while undergoing functional magnetic resonance imaging every 2 h from 22:00 hours on the first day to 06:00 hours on the second day (i...
August 6, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28763048/outdoor-performance-analysis-of-a-photovoltaic-thermal-pvt-collector-with-jet-impingement-and-compound-parabolic-concentrator-cpc
#5
Ahed Hameed Jaaz, Husam Abdulrasool Hasan, Kamaruzzaman Sopian, Abdul Amir H Kadhum, Tayser Sumer Gaaz, Ahmed A Al-Amiery
This paper discusses the effect of jet impingement of water on a photovoltaic thermal (PVT) collector and compound parabolic concentrators (CPC) on electrical efficiency, thermal efficiency and power production of a PVT system. A prototype of a PVT solar water collector installed with a jet impingement and CPC has been designed, fabricated and experimentally investigated. The efficiency of the system can be improved by using jet impingement of water to decrease the temperature of the solar cells. The electrical efficiency and power output are directly correlated with the mass flow rate...
August 1, 2017: Materials
https://www.readbyqxmd.com/read/28743335/-regulation-of-paxillin-tyrosine-phosphorylation-via-inhibition-of-c-abl-kinase-to-protect-ventilator-induce-lung-injury-in-vivo-in-rats
#6
Rong Zhong, Jun Xiao, Chunguang Dai, Zhihui Yu
OBJECTIVE: To determine whether the inhibition of paxillin tyrosine residues 31 and tyrosine residues 118 (Pxn Y31 and Pxn Y118) phosphorylation via inhibition of c-Abl kinase will effectively block its downstream effector molecules vessel endothelium-cadherin (VE-cad), and whether Rho/Rho kinase activation which will induce the vascular barrier dysfunction. METHODS: Ninety healthy male Sprague-Dawley (SD) rats were randomly divided into nine groups (each n =10)...
July 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28740966/portal-vein-thrombosis-as-a-rare-cause-of-abdominal-pain-when-to-consider
#7
Cengiz Tavusbay, Erdinç Kamer, Turan Acar, İbrahim Kokulu, Haldun Kar, Özlem Gür
Extrahepatic portal vein thrombosis (PVT) is a rare condition that is characterized by the presence of thrombus within any segment of the portal vein, including the right and left intrahepatic branches. It may also extend to the splenic or superior mesenteric veins. Portal vein thrombosis may be related to cirrhosis or liver malignancy as well as to local inflammatory conditions in the abdomen and genetic or acquired thrombophilic diseases. Currently, PVT is being increasingly diagnosed due to advances in modern imaging techniques...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28733177/transjugular-local-thrombolysis-with-without-tips-in-patients-with-acute-non-cirrhotic-non-malignant-portal-vein-thrombosis
#8
Christoph Klinger, Bettina Riecken, Arthur Schmidt, Andrea De Gottardi, Benjamin Meier, Jaime Bosch, Karel Caca
BACKGROUND & AIMS: Therapeutic anticoagulation is the standard treatment in patients with acute non-cirrhotic portal vein thrombosis (PVT). In critically ill patients, anticoagulation only may not suffice to achive rapid and stable recanalization. This study evaluates efficacy and safety of transjugular interventional therapy in acute non-cirrhotic PVT. METHODS: This retrospective study includes 17 consecutive patients with acute noncirrhotic, non-malignant PVT...
June 27, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28728622/psychomotor-vigilance-test-and-its-association-with-daytime-sleepiness-and-inflammation-in-sleep-apnea-clinical-implications
#9
Yun Li, Alexandros Vgontzas, Ilia Kritikou, Julio Fernandez-Mendoza, Maria Basta, Slobodanka Pejovic, Jordan Gaines, Edward O Bixler
STUDY OBJECTIVES: Excessive daytime sleepiness (EDS) is a key symptom of obstructive sleep apnea (OSA). The Psychomotor Vigilance Task (PVT) has been suggested as an objective easy-to-use, inexpensive alternative to the Multiple Sleep Latency Test (MSLT) to measure EDS. In patients with OSA, physiological sleepiness, but not subjective EDS (Epworth Sleepiness Scale [ESS]), has been associated with increased levels of the sleep- inducing proinflammatory cytokine interleukin-6 (IL-6). The goal of this study was to assess the association of PVT with objectively measured sleepiness (MSLT) and subjectively measured sleepiness (ESS) and IL-6 levels in patients with OSA...
July 14, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28702574/electrogenerated-chemiluminescence-logic-gate-operations-based-on-molecule-responsive-organic-microwires
#10
Jianmin Gu, Jingxiao Wu, Yahui Gao, Tianhui Wu, Qing Li, Aixue Li, Jian-Yao Zheng, Bin Wen, Faming Gao
Complex logic gate operations using organic microwires as signal transducers based on electrogenerated chemiluminescence (ECL) intensity as the optical readout signal have been developed by taking advantage of the unique ECL reaction between organic semiconductor 9,10-bis(phenylethynyl)anthracene (BPEA) microwires and small molecules. The BPEA microwires, prepared on cleaned-ITO substrate using a simple physical vapor transport (PVT) method, were subsequently used for construction of the ECL sensors. The developed sensor exhibits high ECL efficiency and excellent stability in the presence of co-reactant tripropylamine...
July 27, 2017: Nanoscale
https://www.readbyqxmd.com/read/28697776/exposure-to-blue-light-during-lunch-break-effects-on-autonomic-arousal-and-behavioral-alertness
#11
Emi Yuda, Hiroki Ogasawara, Yutaka Yoshida, Junichiro Hayano
BACKGROUND: Exposures to melanopsin-stimulating (melanopic) component-rich blue light enhance arousal level. We examined their effects in office workers. Eight healthy university office workers were exposed to blue and orange lights for 30 min during lunch break on different days. We compared the effects of light color on autonomic arousal level assessed by heart rate variability (HRV) and behavioral alertness by psychomotor vigilance tests (PVT). Heart rate was higher and high-frequency (HF, 0...
July 11, 2017: Journal of Physiological Anthropology
https://www.readbyqxmd.com/read/28696772/enhanced-detection-of-feigned-cognitive-impairment-using-per-item-response-time-measurements-in-the-word-memory-test
#12
T Lupu, T Elbaum, M Wagner, Y Braw
Response time (RT) is a less obvious outcome measure than conventional accuracy measures used in performance validity tests (PVTs). It is also under less conscious control and is affected by cognitive processes associated with deception. Studies that assessed the utility of RT for the detection of feigned cognitive impairment are however numbered. Moreover, RT variability was not assessed in a clinically used PVT. In the current study, we assessed the utility of RT measures for the detection of feigned cognitive impairment in the Word Memory Test (WMT)...
July 11, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/28695316/interobserver-variability-in-target-volume-delineation-of-hepatocellular-carcinoma-an-analysis-of-the-working-group-stereotactic-radiotherapy-of-the-german-society-for-radiation-oncology-degro
#13
E Gkika, S Tanadini-Lang, S Kirste, P A Holzner, H P Neeff, H C Rischke, T Reese, F Lohaus, M N Duma, K Dieckmann, R Semrau, M Stockinger, D Imhoff, N Kremers, M F Häfner, N Andratschke, U Nestle, A L Grosu, M Guckenberger, T B Brunner
BACKGROUND: Definition of gross tumor volume (GTV) in hepatocellular carcinoma (HCC) requires dedicated imaging in multiple contrast medium phases. The aim of this study was to evaluate the interobserver agreement (IOA) in gross tumor delineation of HCC in a multicenter panel. METHODS: The analysis was performed within the "Stereotactic Radiotherapy" working group of the German Society for Radiation Oncology (DEGRO). The GTVs of three anonymized HCC cases were delineated by 16 physicians from nine centers using multiphasic CT scans...
July 10, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28692008/use-of-the-psychomotor-vigilance-test-in-fitness-for-work-assessments
#14
Steven Lerman, Daniel Mollicone, Sara Coats
OBJECTIVE: The objective of the pilot program was to evaluate the utility of the psychomotor vigilance test (PVT) in aiding clinicians in making fitness for work determinations. METHODS: A 10-minute PVT was incorporated into fitness for work examinations by occupational health staff at two integrated refining/petrochemical plants. Based on all evidence from the clinical examination, including PVT results, clinicians made their fitness for work determination. RESULTS: Employees who were determined to be fit for work had significantly fewer PVT errors than did employees determined to be unfit for work or fit for work with limitations, with t(98) = -14...
August 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28682164/association-of-nonmalignant-portal-vein-thrombosis-and-outcomes-after-transjugular-intrahepatic-portosystemic-shunt-in-patients-with-cirrhosis
#15
Yong Lv, Chuangye He, Zhengyu Wang, Wengang Guo, Jianhong Wang, Wei Bai, Lei Zhang, Qiuhe Wang, Haibo Liu, Bohan Luo, Jing Niu, Kai Li, Jun Tie, Zhanxin Yin, Daiming Fan, Guohong Han
Purpose To assess the effects of preexisting nonmalignant portal vein thrombosis (PVT) on mortality, clinical relapse, shunt dysfunction, and overt hepatic encephalopathy (HE) after transjugular intrahepatic portosystemic shunt (TIPS) placement. Materials and Methods This retrospective study was approved by the institutional ethics committee, and written informed consent was obtained from all patients. From March 2001 to December 2014, 1171 consecutive patients with cirrhosis (762 men, 409 women; mean age, 50...
July 5, 2017: Radiology
https://www.readbyqxmd.com/read/28666312/antithrombin-iii-for-portal-vein-thrombosis-in-patients-with-liver-disease-a-randomized-double-blind-controlled-trial
#16
Hisashi Hidaka, Shigehiro Kokubu, Takahiro Sato, Shinji Katsushima, Namiki Izumi, Takumi Igura, Shingo Asahara, Kazuo Notsumata, Yukio Osaki, Keiji Tsuji, Hirofumi Kawanaka, Tomohiko Akahoshi, Shozo Hirota, Shoichi Matsutani
AIM: Portal vein thrombosis (PVT) is one of the most critical disorders in liver disease patients. These patients have the imbalance of coagulation and coagulation inhibition resulting from decreased levels of coagulation inhibitory factors, such as protein C, protein S, and antithrombin III (AT-III). We designed this randomized, double-blind, placebo-controlled trial comparing the safety and efficacy of AT-III for PVT in liver disease patients with those who received no treatment. METHODS: Eligible patients were diagnosed with the association of thrombus, without tumor thrombus, and thrombus in more than 50% of the cross-sectional lumen of the portal vein...
June 30, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28658826/analysis-of-12-months-clinical-outcomes-associated-with-implantation-of-ultrathin-60-%C3%AE-m-bare-metal-stent-in-an-unselected-real-world-population-with-coronary-artery-disease
#17
Adikesava Naidu Otikunta, Uday Kumar Hosad, Y V Subba Reddy, Srikanth Eruvaram, Ravi Srinivas, Rajeev Garg, Limmy Loret Lobo
INTRODUCTION: In the era of drug-eluting stents, Bare Metal Stent (BMS) has worked its way up to be recognized in several indications. Moreover, literature suggests that strut thickness has been directly related to the restenosis rate. AIM: We intended to evaluate the clinical performance of the ultrathin (60 μm) Flexinnium stent (Sahajanand Medical Technologies Pvt. Ltd. Surat, India) for treatment of a wide range of patients with coronary artery disease in routine clinical practice...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28658800/a-post-marketing-surveillance-study-to-evaluate-performance-of-the-eximo%C3%A2-blood-glucose-monitoring-system
#18
Sonia R Chandnani, C D Ramakrishna, Bhargav A Dave, Pankaj S Kothavade, Ashok S Thakkar
INTRODUCTION: The performance of Blood Glucose Monitoring System (BGMS) is critical as the information provided by the system guide the patient or health care professional in making treatment decisions. However, besides evaluating accuracy of the BGMS in laboratory setting, it is equally important that the intended users (healthcare professionals and patients) should be able to achieve blood glucose measurements with similar level of high accuracy. AIM: To assess the performance of EXIMO™ (Meril Diagnostics Pvt...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28656790/the-dot-counting-test-adds-up-validation-and-response-pattern-analysis-in-a-mixed-clinical-veteran-sample
#19
Jason R Soble, Octavio A Santos, Kathleen M Bain, Joshua W Kirton, K Chase Bailey, Edan A Critchfield, Justin J F O'Rourke, Jonathan M Highsmith, David Andrés González
OBJECTIVE: This study cross-validated the Dot Counting Test (DCT) as a performance validity test (PVT) among a mixed clinical veteran sample. Completion time and error patterns also were examined by validity group and cognitive impairment status. METHOD: This cross-sectional study included 77 veterans who completed the DCT during clinical evaluation. Seventy-four percent (N = 57) were classified as valid and 26% as noncredible (N = 20) via the Word Memory Test (WMT) and Test of Memory Malingering (TOMM)...
June 28, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28633200/complete-response-of-advanced-hepatocellular-carcinoma-to-sorafenib-another-case-and-a-comprehensive-review
#20
Tae Suk Kim, Ji Hoon Kim, Baek Hui Kim, Young-Sun Lee, Yang Jae Yoo, Seong Hee Kang, Sang-June Suh, Young Kul Jung, Yeon Seok Seo, Hyung Joon Yim, Jong Eun Yeon, Kwan Soo Byun
Since sorafenib was introduced in 2007 for treating advanced hepatocellular carcinoma (HCC), 15 patients have achieved a complete response (CR) in advanced HCC. However, only four of these reports can be regarded as real CRs involving adequate assessments including imaging, serum tumor markers, and histologic examinations of completely resected specimens. A 54-year-old man with hepatitis C virus (HCV)-related liver cirrhosis (LC) presented to our unit. A CT scan demonstrated a 3.8-cm arterial hypervascular/portal-washout mass in the right lobe and invasion in the right portal vein...
June 20, 2017: Clinical and Molecular Hepatology
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