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https://www.readbyqxmd.com/read/28059203/hybrid-wavelength-and-frequency-division-multiplexed-fiber-laser-sensor-array
#1
Shengchun Liu, Xue Dong, Xiujuan Yu, Xuefeng Chen, Chao Tian
The Letter describes a hybrid multiplexing scheme for a multi-longitudinal-mode fiber laser sensor array by combining wavelength-division multiplexing and frequency-division multiplexing techniques. The proposed multiplexing system consists of many subgroups, each of which has many fiber laser sensors with approximately equal laser-operating wavelengths but different cavity lengths. Each sensor in one subgroup can be interrogated by using frequency-division multiplexing technology because of different sensors with different beat frequencies...
January 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28057468/evaluation-of-a-newly-developed-mid-infrared-sensor-for-real-time-monitoring-of-yeast-fermentations
#2
Robert Schalk, Daniel Geoerg, Jens Staubach, Matthias Raedle, Frank-Juergen Methner, Thomas Beuermann
A mid-infrared (MIR) sensor using the attenuated total reflection (ATR) technique has been developed for real-time monitoring in biotechnology. The MIR-ATR sensor consists of an IR emitter as light source, a zinc selenide ATR prism as boundary to the process, and four thermopile detectors, each equipped with an optical bandpass filter. The suitability of the sensor for practical application was tested during aerobic batch-fermentations of Saccharomyces cerevisiae by simultaneous monitoring of glucose and ethanol...
January 2, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/28047557/su-g-tep2-15-feasibility-study-of-fiber-optic-cerenkov-radiation-sensors-for-in-vivo-measurement-dosimetric-characterization-and-clinical-application-in-proton-beams
#3
J Lah, J Son, G Kim, D Shin
PURPOSE: To evaluate the possibility of a fiber-optic Cerenkov radiation sensor (FCRS) for in vivo dose verification in proton therapy. METHODS: The Cerenkov radiation due to the proton beam was measured using a homemade phantom, consisting of a plastic optical fiber (POF, PGSCD1001-13-E, Toray, Tokyo, Japan) connected to each channel of a multianode photomultiplier tube (MAPMT:H7546, Hamamatsu Photonics, Shizuoka, Japan). Data were acquired using a multi-anode photomultiplier tube with the NI-DAQ system (National Instruments Texas, USA)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28006679/a-disposable-amperometric-dual-sensor-for-the-detection-of-hemoglobin-and-glycated-hemoglobin-in-a-finger-prick-blood-sample
#4
Jong-Min Moon, Dong-Min Kim, Moo Hyun Kim, Jin-Yeong Han, Dong-Keun Jung, Yoon-Bo Shim
A disposable microfluidic amperometric dual-sensor was developed for the detection of glycated hemoglobin (HbA1C) and total hemoglobin (Hb), separately, in a finger prick blood sample. The accurate level of total Hb was determined through the measurements of the cathodic currents of total Hb catalyzed by a toluidine blue O (TBO)-modified working electrode. Subsequently, after washing unbound Hb in the fluidic channel of dual sensor with PBS, the cathodic current by only HbA1C captured on aptamer was monitored using another aptamer/TBO-modified working electrode in the channel...
December 15, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27940225/migration-and-interaction-tracking-for-quantitative-analysis-of-phagocyte-pathogen-confrontation-assays
#5
Susanne Brandes, Stefanie Dietrich, Kerstin Hünniger, Oliver Kurzai, Marc Thilo Figge
Invasive fungal infections are emerging as a significant health risk for humans. The innate immune system is the first line of defense against invading micro-organisms and involves the recruitment of phagocytes, which engulf and kill pathogens, to the site of infection. To gain a quantitative understanding of the interplay between phagocytes and fungal pathogens, live-cell imaging is a modern approach to monitor the dynamic process of phagocytosis in time and space. However, this requires the processing of large amounts of video data that is tedious to be performed manually...
November 25, 2016: Medical Image Analysis
https://www.readbyqxmd.com/read/27936397/design-of-a-new-comprehensive-continuous-monitoring-system-for-environmental-radioactive-aerosol
#6
Hongkun Xu, Zihan Huang, Ge Wang, Changli Mu, Yin Yin
In order to comprehensive monitoring the radioactive isotopes from nuclear facilities, we developed a dual channel spectral monitoring instrument, and realized synchronous measurement for alpha, beta and gamma radionuclides. This article focuses on how to ensure its accuracy, stability and efficiency. First is the accuracy. In order to lower the interference of environmental and detector performance variation, the zero phase shift filter was designed to ensure the accuracy of characteristic peak position. Lorenz fitting algorithm was designed to reduce the effect of spectral low-energy tailing...
February 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/27935087/a-multi-module-microfluidic-platform-for-continuous-pre-concentration-of-water-soluble-ions-and-separation-of-oil-droplets-from-oil-in-water-o-w-emulsions-using-a-dc-biased-ac-electrokinetic-technique
#7
Dhiman Das, Dinh-Tuan Phan, Yugang Zhao, Yuejun Kang, Vincent Chan, Chun Yang
A novel continuous flow microfluidic platform specifically designed for environmental monitoring of O/W emulsions during an aftermath of oil spills is reported herein. Ionized polycyclic aromatic hydrocarbons which are toxic are readily released from crude oil to the surrounding water phase through the smaller oil droplets with enhanced surface area. Hence, a multi-module microfluidic device is fabricated to form ion enrichment zones in the water phase of O/W emulsions for the ease of detection and to separate micron-sized oil droplets from the O/W emulsions...
December 9, 2016: Electrophoresis
https://www.readbyqxmd.com/read/27910502/filterscope-diagnostic-system-on-the-experimental-advanced-superconducting-tokamak-east
#8
Z Xu, Z W Wu, W Gao, Y J Chen, C R Wu, L Zhang, J Huang, J F Chang, X J Yao, W Gao, P F Zhang, Z Jin, Y M Hou, H Y Guo
A filterscope diagnostic system has been mounted to observe the line emission and visible bremsstrahlung emission from plasma on the experimental advanced superconducting tokamak during the 2014 campaign. By this diagnostic system, multiple wavelengths including Dα (656.1 nm), Dγ (433.9 nm), He ii (468.5 nm), Li i (670.8 nm), Li ii (548.3 nm), C iii (465.0 nm), O ii (441.5 nm), Mo i (386.4 nm), W i (400.9 nm), and visible bremsstrahlung radiation (538.0 nm) are monitored with corresponding wavelength filters...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27857391/super-spectral-resolution-beyond-pixel-nyquist-limits-on-multi-channel-spectrometer
#9
Tsuyoshi Konishi, Yu Yamasaki, Tomotaka Nagashima
Enhancement of the resolution of well-distributed multi-channel spectrometers beyond the pixel Nyquist limits while maintaining their inherent advantages such as high-speed measurement, compactness, and robustness will represent a critical step toward real-time monitoring of dynamic events. Here, we report the first super spectral resolution measurement beyond pixel Nyquist limits which was made possible by employing the Moiré effect in a commercially available Czerny-Turner type spectroscope of 4.63nm-spectral resolution...
November 14, 2016: Optics Express
https://www.readbyqxmd.com/read/27852360/-changes-and-implications-of-esophageal-function-in-patients-with-chronic-cough-induced-by-gastroesophageal-reflux
#10
X H Xu, L Yu, Q Chen, Y Huang, H H Sun, L S Yi, S C Xu, H J Lyu, Z M Qiu
Objective: To explore the changes in the esophageal function and their association with the therapeutic outcome in patients with gastroesophageal reflux-induced chronic cough (GERC). Methods: One hundred thirty-five patients with definite GERC consecutively referred to our respiratory clinic were recruited into the study between January 2012 and August 2015.Cough was due to acid reflux in 81 patients and non-acid reflux in 54 patients, with the favorable response to the standard antireflux therapy in 88 patients and to the intensified antireflux treatment in 47 patients...
November 12, 2016: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/27809712/first-report-of-the-point-of-care-teg-a-technical-validation-study-of-the-teg-6s-system
#11
Paul A Gurbel, Kevin P Bliden, Udaya S Tantry, Amy L Monroe, Adina A Muresan, Norman E Brunner, Carlos G Lopez-Espina, Peter R Delmenico, Eli Cohen, Gabriel Raviv, DeAnna L Haugen, Mark H Ereth
Thrombelastography (TEG) measured by the TEG5000 Hemostasis Analyzer is an established but the labor-intensive method for assessing global hemostasis. The first true point-of-care TEG, the TEG6s system, uses resonance-frequency viscoelasticity measurements and a disposable multi-channel microfluidic cartridge to assess hemostasis and response to antiplatelet therapy. TEG assays (n = 5,100) were performed on the blood of healthy volunteers (n = 157) and patients undergoing coronary revascularization at three hospitals (n = 300)...
November 2016: Platelets
https://www.readbyqxmd.com/read/27743863/a-wearable-multisensing-patch-for-continuous-sweat-monitoring
#12
Salzitsa Anastasova, Blair Crewther, Pawel Bembnowicz, Vincenzo Curto, Henry Md Ip, Bruno Rosa, Guang-Zhong Yang
In sport, exercise and healthcare settings, there is a need for continuous, non-invasive monitoring of biomarkers to assess human performance, health and wellbeing. Here we report the development of a flexible microfluidic platform with fully integrated sensing for on-body testing of human sweat. The system can simultaneously and selectively measure metabolite (e.g. lactate) and electrolytes (e.g. pH, sodium) together with temperature sensing for internal calibration. The construction of the platform is designed such that continuous flow of sweat can pass through an array of flexible microneedle type of sensors (50µm diameter) incorporated in a microfluidic channel...
September 21, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27739407/removal-of-eye-blink-artifacts-in-wireless-eeg-sensor-networks-using-reduced-bandwidth-canonical-correlation-analysis
#13
Ben Somers, Alexander Bertrand
OBJECTIVE: Chronic, 24/7 EEG monitoring requires the use of highly miniaturized EEG modules, which only measure a few EEG channels over a small area. For improved spatial coverage, a wireless EEG sensor network (WESN) can be deployed, consisting of multiple EEG modules, which interact through short-distance wireless communication. In this paper, we aim to remove eye blink artifacts in each EEG channel of a WESN by optimally exploiting the correlation between EEG signals from different modules, under stringent communication bandwidth constraints...
December 2016: Journal of Neural Engineering
https://www.readbyqxmd.com/read/27733926/wearable-multimodal-vitals-acquisition-unit-for-intelligent-field-triage
#14
Christoph Beck, Julius Georgiou
In this Letter, the authors describe the characterisation design and development of the authors' wearable, multimodal vitals acquisition unit for intelligent field triage. The unit is able to record the standard electrocardiogram, blood oxygen and body temperature parameters and also has the unique capability to record up to eight custom designed acoustic streams for heart and lung sound auscultation. These acquisition channels are highly synchronised to fully maintain the time correlation of the signals. The unit is a key component enabling systematic and intelligent field triage to continuously acquire vital patient information...
September 2016: Healthcare Technology Letters
https://www.readbyqxmd.com/read/27709895/multiplex-biosensing-based-on-highly-sensitive-magnetic-nanolabel-quantification-rapid-detection-of-botulinum-neurotoxins-a-b-and-e-in-liquids
#15
Alexey V Orlov, Sergey L Znoyko, Vladimir R Cherkasov, Maxim Petrovich Nikitin, Petr I Nikitin
We present a multiplex quantitative lateral flow (LF) assay for simultaneous on-site detection of botulinum neurotoxin (BoNT) types A, B and E in complex matrices, which is innovative by virtually no sacrifice in performance while transition from the single-plex assays and by characteristics on the level of laboratory quantitative methods. The novel approach to easy multiplexing is realized via joining an on-demand set of single-plex LF strips, which employ magnetic nanolabels, into a miniature cylinder cartridge that mimics LF strip during all assay stages...
October 6, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27704082/evaluation-of-drug-mediated-arrhythmic-changes-in-spontaneous-beating-cardiomyocytes-by-afm
#16
A T Chen, S Zou
Arrhythmia caused by drug-induced cardiotoxicity is among the leading reasons for late-stage drug attrition and is therefore a core subject in safety testing of new compounds. Alternative methods such as surface and interface characterization approaches for assessing the drug-mediated cardiotoxicity should be promoted, in order to reduce, refine and replace the use of laboratory animals. Here, we investigate the possibility of using known human Ether-à-go-go-Related Gene (hERG) channel blockers to induce irregular beating patterns in the mouse and human induced pluripotent stem cell-derived (miPSC and hiPSC) cardiomyocyte (CM) model systems...
September 29, 2016: Analyst
https://www.readbyqxmd.com/read/27698453/possible-neural-mechanisms-of-psychotherapy-for-trauma-related-symptoms-cerebral-responses-to-the-neuropsychological-treatment-of-post-traumatic-stress-disorder-model-individuals
#17
Tamaki Amano, Motomi Toichi
Psychotherapy is often effective for treating psychogenic disorders, but the changes that occur in the brain during such treatments remain unknown. To investigate this, we monitored cerebral activity throughout an entire session using a psychotherapeutic technique in healthy subjects. Since post-traumatic stress disorder (PTSD) is a typical psychogenic psychiatric disorder, we used PTSD-model volunteers who had experienced a moderately traumatic event. The technique used as psychotherapy was eye movement desensitisation and reprocessing (EMDR), a standard method for treating PTSD...
October 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27686605/a-unique-iridium-iii-complex-based-chemosensor-for-multi-signal-detection-and-multi-channel-imaging-of-hypochlorous-acid-in-liver-injury
#18
Feiyue Zhang, Xiaowen Liang, Wenzhu Zhang, Yong-Lei Wang, Haolu Wang, Yousuf H Mohammed, Bo Song, Run Zhang, Jingli Yuan
Although hypochlorous acid (HOCl) has long been associated with a number of inflammatory diseases in mammalian bodies, the functions of HOCl in specific organs at abnormal conditions, such as liver injury, remain unclear due to its high reactivity and the lack of effective methods for its detection. Herein, a unique Ir(III) complex-based chemosensor, Ir-Fc, was developed for highly sensitive and selective detection of HOCl. Ir-Fc was designed by incorporating a ferrocene (Fc) quencher to a Ir(III) complex through a HOCl-responsive linker...
January 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27664409/a-portable-and-multiplexed-bioelectronic-sensor-using-human-olfactory-and-taste-receptors
#19
Manki Son, Daesan Kim, Hwi Jin Ko, Seunghun Hong, Tai Hyun Park
A multiplexed bioelectronic sensor was developed for the purpose of rapid, on-site, and simultaneous detection of various target molecules. Olfactory and taste receptors were produced in Escherichia coli, and the reconstituted receptors were immobilized onto a multi-channel type carbon nanotube field-effect transistor. This device mimicked the human olfactory/taste system and simultaneously measured the conductance changes with high sensitivity and selectivity following treatment with various odor and taste molecules commonly known to be indicators of food contamination...
January 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27660209/efficacy-and-safety-of-pregabalin-for-the-treatment-of-neuropathic-pain-in-patients-undergoing-hemodialysis
#20
Tomoyasu Otsuki, Terumi Higuchi, Toshio Yamazaki, Erina Okawa, Kazuyoshi Okada, Masanori Abe
OBJECTIVE: Pregabalin is a gamma aminobutyric acid derivative administered for neuropathic pain. It binds to α2δ subunits of voltage-dependent calcium channels, and inhibits calcium inflow of synapses and the release of excitatory neurotransmitters. This study investigated the efficacy and safety of pregabalin in patients with peripheral neuropathic pain undergoing maintenance hemodialysis. METHODS: This study was a prospective, open-label, single-arm, multi-center trial...
January 2017: Clinical Drug Investigation
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