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https://www.readbyqxmd.com/read/29329017/amiodarone-a-multi-channel-blocker-enhances-anticonvulsive-effect-of-carbamazepine-in-the-mouse-maximal-electroshock-model
#1
Monika Banach, Monika Popławska, Kinga K Borowicz-Reutt
Cardiac arrhythmia may occur in the course of epilepsy. Simultaneous therapy of the two diseases might be complicated by drug interactions since antiarrhythmic and antiepileptic agents share some molecular targets. The aim of this study was to evaluate the influence of amiodarone, an antiarrhythmic drug working as a multi-channel blocker, on the protective activity of four classical antiepileptic drugs in the maximal electroshock test in mice. Amiodarone at doses up to 75 mg/kg did not affect the electroconvulsive threshold in mice...
January 5, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29318567/phenotyping-the-pathophysiology-of-obstructive-sleep-apnea-using-polygraphy-polysomnography-a-review-of-the-literature
#2
REVIEW
Marcello Bosi, Andrea De Vito, Bhik Kotecha, Luca Viglietta, Alberto Braghiroli, Joerg Steier, Martino Pengo, Giovanni Sorrenti, Riccardo Gobbi, Claudio Vicini, Venerino Poletti
Continuous positive airway pressure (CPAP) is the first-line treatment for the majority of patients affected by obstructive sleep apnea syndrome (OSA). However, long-term compliance with CPAP therapy may result limited and alternatives to CPAP therapy are required to address the increasing need to provide tailored therapeutic options. Understanding the pathophysiological traits (PTs) of OSA patients [upper airway (UA) anatomical collapsibility, loop gain (LG), arousal threshold (AT), and UA gain (UAG)] lies at the heart of the customized OSA treatment...
January 9, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29283402/real-time-monitoring-and-analysis-of-zebrafish-electrocardiogram-with-anomaly-detection
#3
Michael Lenning, Joseph Fortunato, Tai Le, Isaac Clark, Ang Sherpa, Soyeon Yi, Peter Hofsteen, Geethapriya Thamilarasu, Jingchun Yang, Xiaolei Xu, Huy-Dung Han, Tzung K Hsiai, Hung Cao
Heart disease is the leading cause of mortality in the U.S. with approximately 610,000 people dying every year. Effective therapies for many cardiac diseases are lacking, largely due to an incomplete understanding of their genetic basis and underlying molecular mechanisms. Zebrafish (Danio rerio) are an excellent model system for studying heart disease as they enable a forward genetic approach to tackle this unmet medical need. In recent years, our team has been employing electrocardiogram (ECG) as an efficient tool to study the zebrafish heart along with conventional approaches, such as immunohistochemistry, DNA and protein analyses...
December 28, 2017: Sensors
https://www.readbyqxmd.com/read/29236042/single-channel-eeg-artifact-identification-using-two-dimensional-multi-resolution-analysis
#4
Mojtaba Taherisadr, Omid Dehzangi, Hossein Parsaei
As a diagnostic monitoring approach, electroencephalogram (EEG) signals can be decoded by signal processing methodologies for various health monitoring purposes. However, EEG recordings are contaminated by other interferences, particularly facial and ocular artifacts generated by the user. This is specifically an issue during continuous EEG recording sessions, and is therefore a key step in using EEG signals for either physiological monitoring and diagnosis or brain-computer interface to identify such artifacts from useful EEG components...
December 13, 2017: Sensors
https://www.readbyqxmd.com/read/29221091/raman-lidar-for-hydrogen-gas-concentration-monitoring-and-future-radioactive-waste-management
#5
Anasthase Liméry, Nicolas Cézard, Didier Fleury, Didier Goular, Christophe Planchat, Johan Bertrand, Alain Hauchecorne
A multi-channel Raman lidar has been developed, allowing for the first time simultaneous and high-resolution profiling of hydrogen gas and water vapor. The lidar measures vibrational Raman scattering in the UV (355 nm) domain. It works in a high-bandwidth photon counting regime using fast SiPM detectors and takes into account the spectral overlap between hydrogen and water vapor Raman spectra. Measurement of concentration profiles of H2 and H2O are demonstrated along a 5-meter-long open gas cell with 1-meter resolution at 85 meters...
November 27, 2017: Optics Express
https://www.readbyqxmd.com/read/29199161/indications-of-24-h-esophageal-ph-monitoring-capsule-ph-monitoring-combined-ph-monitoring-with-multichannel-impedance-esophageal-manometry-radiology-and-scintigraphy-in-gastroesophageal-reflux-disease
#6
Rukiye Vardar, Muharrem Keskin
Ambulatory esophageal pH monitoring is an essential method in patients exhibiting signs of non-erosive reflux disease (NERD) to make an objective diagnosis. Intra-esophageal pH monitoring is important in patients who are non-responsive to medications and in those with extraesophageal symptoms, particularly in NERD, before surgical interventions. With the help of the wireless capsule pH monitoring, measurements can be made under more physiological conditions as well as longer recordings can be performed because the investigation can be better tolerated by patients...
December 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29193178/integrated-microfluidic-biosensing-platform-for-simultaneous-confocal-microscopy-and-electrophysiological-measurements-on-bilayer-lipid-membranes-and-ion-channels
#7
Verena C Schulze Greiving, Hans L de Boer, Johan G Bomer, Albert van den Berg, Séverine Le Gac
Combining high-resolution imaging and electrophysiological recordings is key for various types of experimentation on lipid bilayers and ion channels. Here, we propose an integrated biosensing platform consisting of a microfluidic cartridge and a dedicated chip-holder to conduct such dual measurements on suspended lipid bilayers, in a user-friendly manner. To illustrate the potential of the integrated platform, we characterize lipid bilayers in terms of thickness and fluidity while simultaneously monitoring single ion channel currents...
November 29, 2017: Electrophoresis
https://www.readbyqxmd.com/read/29175218/a-multi-functional-gold-iron-oxide-nanoparticle-cnt-hybrid-nanomaterial-as-virus-dna-sensing-platform
#8
Jaewook Lee, Masahiro Morita, Kenshin Takemura, Enoch Y Park
Nanoparticle (NP)-carbon nanomaterial hybrid structures have garnered significant attention due to their synergistic effects. Based on their interesting properties, hybrid nanomaterial-based sensing platforms have been investigated to achieve high sensitivity and selectivity detection. In our study, binary-NP-decorated carbon nanotubes (bNP-CNTs) were successfully synthesized through a simple two-step method and applied as a biosensing platform. Gold (Au)/iron-oxide magnetic NP-decorated CNTs (Au/MNP-CNT) were used for influenza and norovirus DNA sensing channels...
November 21, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29092192/simultaneous-four-channel-thermal-adaptation-of-polarization-insensitive-silicon-photonics-wdm-receiver
#9
Robert Gatdula, Kwangwoong Kim, Argishti Melikyan, Young-Kai Chen, Po Dong
We propose a novel approach to demonstrate simultaneous multi-wavelength locking during temperature changes in a silicon photonic polarization insensitive microring-based wavelength division multiplexing (WDM) receiver. The DC component of a single monitoring photodetector at the through port of the microring filter array is exploited as a feedback signal with no additional power consumption. This feedback signal is used in control circuitry to properly tune the microring filters using ohmic heating, thus creating a feedback loop for thermal adaptation...
October 30, 2017: Optics Express
https://www.readbyqxmd.com/read/29089896/a-comparative-study-on-fetal-heart-rates-estimated-from-fetal-phonography-and-cardiotocography
#10
Emad A Ibrahim, Shamsa Al Awar, Zuhur H Balayah, Leontios J Hadjileontiadis, Ahsan H Khandoker
The aim of this study is to investigate that fetal heart rates (fHR) extracted from fetal phonocardiography (fPCG) could convey similar information of fHR from cardiotocography (CTG). Four-channel fPCG sensors made of low cost (<$1) ceramic piezo vibration sensor within 3D-printed casings were used to collect abdominal phonogram signals from 20 pregnant mothers (>34 weeks of gestation). A novel multi-lag covariance matrix-based eigenvalue decomposition technique was used to separate maternal breathing, fetal heart sounds (fHS) and maternal heart sounds (mHS) from abdominal phonogram signals...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29080563/advanced-control-synthesis-for-reverse-osmosis-water-desalination-processes
#11
Bui Duc Hong Phuc, Sam-Sang You, Hyeung-Six Choi, Seok-Kwon Jeong
  In this study, robust control synthesis has been applied to a reverse osmosis desalination plant whose product water flow and salinity are chosen as two controlled variables. The reverse osmosis process has been selected to study since it typically uses less energy than thermal distillation. The aim of the robust design is to overcome the limitation of classical controllers in dealing with large parametric uncertainties, external disturbances, sensor noises, and unmodeled process dynamics. The analyzed desalination process is modeled as a multi-input multi-output (MIMO) system with varying parameters...
November 1, 2017: Water Environment Research: a Research Publication of the Water Environment Federation
https://www.readbyqxmd.com/read/29060515/physical-activity-classification-using-time-frequency-signatures-of-motion-artifacts-in-multi-channel-electrical-impedance-plethysmographs
#12
Hassan Aqeel Khan, Amit Gore, Jeff Ashe, Shantanu Chakrabartty
Physical activities are known to introduce motion artifacts in electrical impedance plethysmographic (EIP) sensors. Existing literature considers motion artifacts as a nuisance and generally discards the artifact containing portion of the sensor output. This paper examines the notion of exploiting motion artifacts for detecting the underlying physical activities which give rise to the artifacts in question. In particular, we investigate whether the artifact pattern associated with a physical activity is unique; and does it vary from one human-subject to another? Data was recorded from 19 adult human-subjects while conducting 5 distinct, artifact inducing, activities...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29057872/modelling-torsade-de-pointes-arrhythmias-in-vitro-in-3d-human-ips-cell-engineered-heart-tissue
#13
Masahide Kawatou, Hidetoshi Masumoto, Hiroyuki Fukushima, Gaku Morinaga, Ryuzo Sakata, Takashi Ashihara, Jun K Yamashita
Torsade de Pointes (TdP) is a lethal arrhythmia that is often drug-induced, thus there is an urgent need for development of models to test or predict the drug sensitivity of human cardiac tissue. Here, we present an in vitro TdP model using 3D cardiac tissue sheets (CTSs) that contain a mixture of human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes and non-myocytes. We simultaneously monitor the extracellular field potential (EFP) and the contractile movement of the CTSs. Upon treatment with IKr channel blockers, CTSs exhibit tachyarrhythmias with characteristics of TdP, including both a typical polymorphic EFP and meandering spiral wave re-entry...
October 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/29041476/segmented-detection-spr-sensor-based-on-seven-core-fiber
#14
Yong Wei, Yudong Su, Chunlan Liu, Yonghui Zhang, Xiangfei Nie, Zhihai Liu, Yu Zhang, Feng Peng
By using a seven-core fiber (SCF), we propose and demonstrate a novel segmented detection SPR sensor, which solves two bottlenecks about the fiber SPR sensor of low sensitivity and the difficulty in the multichannel detection. The proposed sensor has ultra high sensitivity and wide detection range because of employing the segmented detection technology. Besides that, the proposed sensor employs reflection-type time division multiplexing (TDM) technology in fiber multichannel detection for the first time. We couple light into and out of the six circularly symmetric distributed cores of the seven-core fiber to realize the three channel SPR sensing and testing...
September 4, 2017: Optics Express
https://www.readbyqxmd.com/read/29020445/direct-metal-writing-and-precise-positioning-of-gold-nanoparticles-within-microfluidic-channels-for-sers-sensing-of-gaseous-analytes
#15
Mian Rong Lee, Hiang Kwee Lee, Yijie Yang, Charlynn Sher Lin Koh, Chee Leng Lay, Yih Hong Lee, In Yee Phang, Xing Yi Ling
We demonstrate a one-step precise direct metal writing of well-defined and densely packed gold nanoparticle (AuNP) patterns with tunable physical and optical properties. We achieve this by using two-photon lithography on a Au precursor comprising poly(vinylpyrrolidone) (PVP) and ethylene glycol (EG), where EG promotes higher reduction rates of Au(III) salt via polyol reduction. Hence, clusters of monodisperse AuNP are generated along raster scanning of the laser, forming high-particle-density, well-defined structures...
November 1, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29018638/automatic-sleep-monitoring-using-ear-eeg
#16
Takashi Nakamura, Valentin Goverdovsky, Mary J Morrell, Danilo P Mandic
The monitoring of sleep patterns without patient's inconvenience or involvement of a medical specialist is a clinical question of significant importance. To this end, we propose an automatic sleep stage monitoring system based on an affordable, unobtrusive, discreet, and long-term wearable in-ear sensor for recording the electroencephalogram (ear-EEG). The selected features for sleep pattern classification from a single ear-EEG channel include the spectral edge frequency and multi-scale fuzzy entropy, a structural complexity feature...
2017: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/28966475/centrifugal-microfluidics-for-sorting-immune-cells-from-whole-blood
#17
Zeta Tak For Yu, Jophin George Joseph, Shirley Xiaosu Liu, Mei Ki Cheung, Parker James Haffey, Katsuo Kurabayashi, Jianping Fu
Sorting and enumeration of immune cells from blood are critical operations involved in many clinical applications. Conventional methods for sorting and counting immune cells from blood, such as flow cytometry and hemocytometers, are tedious, inaccurate, and difficult for implementation for point-of-care (POC) testing. Herein we developed a microscale centrifugal technology termed Centrifugal Microfluidic Chip (CMC) capable of sorting immune cells from blood and in situ cellular analysis in a laboratory setting...
June 2017: Sensors and Actuators. B, Chemical
https://www.readbyqxmd.com/read/28943300/effect-of-chaotropes-on-the-kinetics-of-iron-release-from-ferritin-by-flavin-nucleotides
#18
Lindsay E Johnson, Tyler Wilkinson, Paolo Arosio, Artem Melman, Fadi Bou-Abdallah
BACKGROUND: Ferritins are ubiquitous multi-subunit iron storage and detoxification proteins that play a critical role in iron homeostasis. Ferrous ions that enter the protein's shell through hydrophilic channels are rapidly oxidized at dinuclear centers on the H-subunit before transfer to the protein's cavity for storage. The mechanisms of iron loading have been extensively studied, but little is known about iron mobilization. Fe(III) reduction can occur via rapid reduction by suitable reducing agents followed by chelation of Fe(II) ions or via direct and slow Fe(III) chelation...
December 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28905426/optically-controlled-on-coil-amplifier-with-rf-monitoring-feedback
#19
Natalia Gudino, Jacco A de Zwart, Qi Duan, Stephen J Dodd, Joe Murphy-Boesch, Peter van Gelderen, Jeff H Duyn
PURPOSE: To develop a new optically controlled on-coil amplifier that facilitates safe use of multi-channel radiofrequency (RF) transmission in MRI by real-time monitoring of signal phase and amplitude. METHODS: Monitoring was carried out with a 4-channel prototype system by sensing, down sampling, digitizing, and optically transmitting the RF transmit signal to a remote PC to control the amplifiers. Performance was evaluated with benchtop and 7 T MRI experiments...
September 14, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28895021/k-band-doppler-radar-for-contact-less-overnight-sleep-marker-assessment-a-pilot-validation-study
#20
Rakesh Vasireddy, Corinne Roth, Johannes Mathis, Josef Goette, Marcel Jacomet, Andreas Vogt
An estimated 45 million persons in Europe are annually subjected to sleep-wake disorders. State-of-the-art polysomnography provides sophisticated insights into sleep (patho)physiology. A drawback of the method, however, is the obtrusive setting dependent on a clinical-based sleep laboratory with high operational costs. A contact-less prototype was developed to monitor limb movements and vital signs during sleep. A dual channel K-band Doppler radar transceiver captured limb movements and periodic chest wall motion due to respiration and heart activity...
September 11, 2017: Journal of Clinical Monitoring and Computing
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