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https://www.readbyqxmd.com/read/27910502/filterscope-diagnostic-system-on-the-experimental-advanced-superconducting-tokamak-east
#1
Z Xu, Z W Wu, W Gao, Y J Chen, C R Wu, L Zhang, J Huang, J F Chang, X J Yao, W Gao, P F Zhang, Z Jin, Y M Hou, H Y Guo
A filterscope diagnostic system has been mounted to observe the line emission and visible bremsstrahlung emission from plasma on the experimental advanced superconducting tokamak during the 2014 campaign. By this diagnostic system, multiple wavelengths including Dα (656.1 nm), Dγ (433.9 nm), He ii (468.5 nm), Li i (670.8 nm), Li ii (548.3 nm), C iii (465.0 nm), O ii (441.5 nm), Mo i (386.4 nm), W i (400.9 nm), and visible bremsstrahlung radiation (538.0 nm) are monitored with corresponding wavelength filters...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27857391/super-spectral-resolution-beyond-pixel-nyquist-limits-on-multi-channel-spectrometer
#2
Tsuyoshi Konishi, Yu Yamasaki, Tomotaka Nagashima
Enhancement of the resolution of well-distributed multi-channel spectrometers beyond the pixel Nyquist limits while maintaining their inherent advantages such as high-speed measurement, compactness, and robustness will represent a critical step toward real-time monitoring of dynamic events. Here, we report the first super spectral resolution measurement beyond pixel Nyquist limits which was made possible by employing the Moiré effect in a commercially available Czerny-Turner type spectroscope of 4.63nm-spectral resolution...
November 14, 2016: Optics Express
https://www.readbyqxmd.com/read/27852360/-changes-and-implications-of-esophageal-function-in-patients-with-chronic-cough-induced-by-gastroesophageal-reflux
#3
X H Xu, L Yu, Q Chen, Y Huang, H H Sun, L S Yi, S C Xu, H J Lyu, Z M Qiu
Objective: To explore the changes in the esophageal function and their association with the therapeutic outcome in patients with gastroesophageal reflux-induced chronic cough (GERC). Methods: One hundred thirty-five patients with definite GERC consecutively referred to our respiratory clinic were recruited into the study between January 2012 and August 2015.Cough was due to acid reflux in 81 patients and non-acid reflux in 54 patients, with the favorable response to the standard antireflux therapy in 88 patients and to the intensified antireflux treatment in 47 patients...
November 12, 2016: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/27809712/first-report-of-the-point-of-care-teg-a-technical-validation-study-of-the-teg-6s-system
#4
Paul A Gurbel, Kevin P Bliden, Udaya S Tantry, Amy L Monroe, Adina A Muresan, Norman E Brunner, Carlos G Lopez-Espina, Peter R Delmenico, Eli Cohen, Gabriel Raviv, DeAnna L Haugen, Mark H Ereth
Thrombelastography (TEG) measured by the TEG5000 Hemostasis Analyzer is an established but the labor-intensive method for assessing global hemostasis. The first true point-of-care TEG, the TEG6s system, uses resonance-frequency viscoelasticity measurements and a disposable multi-channel microfluidic cartridge to assess hemostasis and response to antiplatelet therapy. TEG assays (n = 5,100) were performed on the blood of healthy volunteers (n = 157) and patients undergoing coronary revascularization at three hospitals (n = 300)...
November 2016: Platelets
https://www.readbyqxmd.com/read/27743863/a-wearable-multisensing-patch-for-continuous-sweat-monitoring
#5
Salzitsa Anastasova, Blair Crewther, Pawel Bembnowicz, Vincenzo Curto, Henry Md Ip, Bruno Rosa, Guang-Zhong Yang
In sport, exercise and healthcare settings, there is a need for continuous, non-invasive monitoring of biomarkers to assess human performance, health and wellbeing. Here we report the development of a flexible microfluidic platform with fully integrated sensing for on-body testing of human sweat. The system can simultaneously and selectively measure metabolite (e.g. lactate) and electrolytes (e.g. pH, sodium) together with temperature sensing for internal calibration. The construction of the platform is designed such that continuous flow of sweat can pass through an array of flexible microneedle type of sensors (50µm diameter) incorporated in a microfluidic channel...
September 21, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27739407/removal-of-eye-blink-artifacts-in-wireless-eeg-sensor-networks-using-reduced-bandwidth-canonical-correlation-analysis
#6
Ben Somers, Alexander Bertrand
OBJECTIVE: Chronic, 24/7 EEG monitoring requires the use of highly miniaturized EEG modules, which only measure a few EEG channels over a small area. For improved spatial coverage, a wireless EEG sensor network (WESN) can be deployed, consisting of multiple EEG modules, which interact through short-distance wireless communication. In this paper, we aim to remove eye blink artifacts in each EEG channel of a WESN by optimally exploiting the correlation between EEG signals from different modules, under stringent communication bandwidth constraints...
December 2016: Journal of Neural Engineering
https://www.readbyqxmd.com/read/27733926/wearable-multimodal-vitals-acquisition-unit-for-intelligent-field-triage
#7
Christoph Beck, Julius Georgiou
In this Letter, the authors describe the characterisation design and development of the authors' wearable, multimodal vitals acquisition unit for intelligent field triage. The unit is able to record the standard electrocardiogram, blood oxygen and body temperature parameters and also has the unique capability to record up to eight custom designed acoustic streams for heart and lung sound auscultation. These acquisition channels are highly synchronised to fully maintain the time correlation of the signals. The unit is a key component enabling systematic and intelligent field triage to continuously acquire vital patient information...
September 2016: Healthcare Technology Letters
https://www.readbyqxmd.com/read/27709895/multiplex-biosensing-based-on-highly-sensitive-magnetic-nanolabel-quantification-rapid-detection-of-botulinum-neurotoxins-a-b-and-e-in-liquids
#8
Alexey V Orlov, Sergey L Znoyko, Vladimir R Cherkasov, Maxim Petrovich Nikitin, Petr I Nikitin
We present a multiplex quantitative lateral flow (LF) assay for simultaneous on-site detection of botulinum neurotoxin (BoNT) types A, B and E in complex matrices, which is innovative by virtually no sacrifice in performance while transition from the single-plex assays and by characteristics on the level of laboratory quantitative methods. The novel approach to easy multiplexing is realized via joining an on-demand set of single-plex LF strips, which employ magnetic nanolabels, into a miniature cylinder cartridge that mimics LF strip during all assay stages...
October 6, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27704082/evaluation-of-drug-mediated-arrhythmic-changes-in-spontaneous-beating-cardiomyocytes-by-afm
#9
A T Chen, S Zou
Arrhythmia caused by drug-induced cardiotoxicity is among the leading reasons for late-stage drug attrition and is therefore a core subject in safety testing of new compounds. Alternative methods such as surface and interface characterization approaches for assessing the drug-mediated cardiotoxicity should be promoted, in order to reduce, refine and replace the use of laboratory animals. Here, we investigate the possibility of using known human Ether-à-go-go-Related Gene (hERG) channel blockers to induce irregular beating patterns in the mouse and human induced pluripotent stem cell-derived (miPSC and hiPSC) cardiomyocyte (CM) model systems...
September 29, 2016: Analyst
https://www.readbyqxmd.com/read/27698453/possible-neural-mechanisms-of-psychotherapy-for-trauma-related-symptoms-cerebral-responses-to-the-neuropsychological-treatment-of-post-traumatic-stress-disorder-model-individuals
#10
Tamaki Amano, Motomi Toichi
Psychotherapy is often effective for treating psychogenic disorders, but the changes that occur in the brain during such treatments remain unknown. To investigate this, we monitored cerebral activity throughout an entire session using a psychotherapeutic technique in healthy subjects. Since post-traumatic stress disorder (PTSD) is a typical psychogenic psychiatric disorder, we used PTSD-model volunteers who had experienced a moderately traumatic event. The technique used as psychotherapy was eye movement desensitisation and reprocessing (EMDR), a standard method for treating PTSD...
October 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27686605/a-unique-iridium-iii-complex-based-chemosensor-for-multi-signal-detection-and-multi-channel-imaging-of-hypochlorous-acid-in-liver-injury
#11
Feiyue Zhang, Xiaowen Liang, Wenzhu Zhang, Yong-Lei Wang, Haolu Wang, Yousuf H Mohammed, Bo Song, Run Zhang, Jingli Yuan
Although hypochlorous acid (HOCl) has long been associated with a number of inflammatory diseases in mammalian bodies, the functions of HOCl in specific organs at abnormal conditions, such as liver injury, remain unclear due to its high reactivity and the lack of effective methods for its detection. Herein, a unique Ir(III) complex-based chemosensor, Ir-Fc, was developed for highly sensitive and selective detection of HOCl. Ir-Fc was designed by incorporating a ferrocene (Fc) quencher to a Ir(III) complex through a HOCl-responsive linker...
September 20, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27664409/a-portable-and-multiplexed-bioelectronic-sensor-using-human-olfactory-and-taste-receptors
#12
Manki Son, Daesan Kim, Hwi Jin Ko, Seunghun Hong, Tai Hyun Park
A multiplexed bioelectronic sensor was developed for the purpose of rapid, on-site, and simultaneous detection of various target molecules. Olfactory and taste receptors were produced in Escherichia coli, and the reconstituted receptors were immobilized onto a multi-channel type carbon nanotube field-effect transistor. This device mimicked the human olfactory/taste system and simultaneously measured the conductance changes with high sensitivity and selectivity following treatment with various odor and taste molecules commonly known to be indicators of food contamination...
September 17, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27660209/efficacy-and-safety-of-pregabalin-for-the-treatment-of-neuropathic-pain-in-patients-undergoing-hemodialysis
#13
Tomoyasu Otsuki, Terumi Higuchi, Toshio Yamazaki, Erina Okawa, Kazuyoshi Okada, Masanori Abe
OBJECTIVE: Pregabalin is a gamma aminobutyric acid derivative administered for neuropathic pain. It binds to α2δ subunits of voltage-dependent calcium channels, and inhibits calcium inflow of synapses and the release of excitatory neurotransmitters. This study investigated the efficacy and safety of pregabalin in patients with peripheral neuropathic pain undergoing maintenance hemodialysis. METHODS: This study was a prospective, open-label, single-arm, multi-center trial...
September 23, 2016: Clinical Drug Investigation
https://www.readbyqxmd.com/read/27631683/a-multichannel-smartphone-optical-biosensor-for-high-throughput-point-of-care-diagnostics
#14
Li-Ju Wang, Yu-Chung Chang, Rongrong Sun, Lei Li
Current reported smartphone spectrometers are only used to monitor or measure one sample at a time. For the first time, we demonstrate a multichannel smartphone spectrometer (MSS) as an optical biosensor that can simultaneously optical sense multiple samples. In this work, we developed a novel method to achieve the multichannel optical spectral sensing with nanometer resolution on a smartphone. A 3D printed cradle held the smartphone integrated with optical components. This optical sensor performed accurate and reliable spectral measurements by optical intensity changes at specific wavelength or optical spectral shifts...
September 9, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27607279/mid-infrared-absorption-spectroscopy-based-carbon-dioxide-sensor-network-in-greenhouse-agriculture-development-and-deployment
#15
Jianing Wang, Lingjiao Zheng, Xintao Niu, Chuantao Zheng, Yiding Wang, Frank K Tittel
A mid-infrared carbon dioxide (CO<sub>2</sub>) sensor was experimentally demonstrated for application in a greenhouse farm environment. An optical module was developed using a lamp source, a dual-channel pyre-electrical detector, and a spherical mirror. A multi-pass gas chamber and a dual-channel detection method were adopted to effectively enhance light collection efficiency and suppress environmental influences. The moisture-proof function realized by a breathable waterproof chamber was specially designed for the application of such a sensor in a greenhouse with high humidity...
September 1, 2016: Applied Optics
https://www.readbyqxmd.com/read/27592326/assessing-the-natural-and-anthropogenic-influences-on-basin-wide-fish-species-richness
#16
Su-Ting Cheng, Edwin E Herricks, Wen-Ping Tsai, Fi-John Chang
Theory predicts that the number of fish species increases with river size in natural free-flowing rivers, but the relationship is lost under intensive exploitation of water resources associated with dams and/or landscape developments. In this paper, we aim to identify orthomorphic issues that disrupt theoretical species patterns based on a multi-year, basin-wide assessment in the Danshuei River Watershed of Taiwan. We hypothesize that multiple human-induced modifications fragment habitat areas leading to decreases of local fish species richness...
August 31, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27556995/design-and-daytime-performance-of-laser-induced-fluorescence-spectrum-lidar-for-simultaneous-detection-of-multiple-components-dissolved-organic-matter-phycocyanin-and-chlorophyll-in-river-water
#17
Yasunori Saito, Kei Kakuda, Mizuho Yokoyama, Tomoki Kubota, Takayuki Tomida, Ho-Dong Park
In this work, we developed mobile laser-induced fluorescence spectrum (LIFS) lidar based on preliminary experiments on the excitation emission matrix of a water sample and a method for reducing solar background light using the synchronous detection technique. The combination of a UV short-pulse laser (355 nm, 6 ns) for fluorescence excitation with a 10-100 ns short-time synchronous detection using a gated image-intensified multi-channel CCD of the fluorescence made the LIFS lidar operation possible even in daytime...
August 20, 2016: Applied Optics
https://www.readbyqxmd.com/read/27550655/multiple-dose-pharmacokinetics-and-safety-of-sulcardine-sulfate-in-healthy-chinese-male-subjects-an-open-label-phase-i-clinical-study
#18
Wei Wang, Hong-Jie Qian, Liang Xin, Meng-Qi Zhang, Dong-Ying Lu, Jie-Mei Jin, Gang-Yi Liu, Jing-Ying Jia, Hong-Chao Zheng, Chen Yu, Yi-Ping Wang, Fu Zhu, Yun Liu
BACKGROUND: Sulcardine sulfate is a novel antiarrhythmic agent with mechanism of action as a multi-ion channel blocker. Preclinical studies in animal models have demonstrated that sulcardine sulfate is efficacious in atrial and ventricular arrhythmias, and consequently, leads to the prevention of sudden cardiac death. OBJECTIVES: This study was conducted in healthy Chinese male subjects to investigate the pharmacokinetic profile and safety of sulcardine sulfate after repeated oral dose administration at 200, 400, and 800 mg for 5 days...
August 22, 2016: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/27454710/life-threatening-false-alarm-rejection-in-icu-using-the-rule-based-and-multi-channel-information-fusion-method
#19
Chengyu Liu, Lina Zhao, Hong Tang, Qiao Li, Shoushui Wei, Jianqing Li
False alarm (FA) rates as high as 86% have been reported in intensive care unit monitors. High FA rates decrease quality of care by slowing staff response times while increasing patient burdens and stresses. In this study, we proposed a rule-based and multi-channel information fusion method for accurately classifying the true or false alarms for five life-threatening arrhythmias: asystole (ASY), extreme bradycardia (EBR), extreme tachycardia (ETC), ventricular tachycardia (VTA) and ventricular flutter/fibrillation (VFB)...
August 2016: Physiological Measurement
https://www.readbyqxmd.com/read/27438427/safety-of-mannitol-use-in-bowel-preparation-a-prospective-assessment-of-intestinal-methane-ch4-levels-during-colonoscopy-after-mannitol-and-sodium-phosphate-nap-bowel-cleansing
#20
Gustavo Andrade de Paulo, Fernanda Prata Borges Martins, Erika Pereira de Macedo, Manoel Ernesto Peçanha Gonçalves, Angelo Paulo Ferrari
BACKGROUND: - Adequate bowel preparation is critical for the quality of colonoscopy. Despite reported occurrence of colonic explosion due to methane and hydrogen production by bacterial fermentation during colonoscopy, gas exchange during the procedure is believed to be effective in lowering existing methane concentration, allowing for safe utilization of mannitol for bowel preparation. Thus, mannitol is widely used for bowel cleansing prior to colonoscopy, considering its low cost and effectiveness for bowel preparation...
July 2016: Arquivos de Gastroenterologia
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