Kazuo Washida, Satoshi Saito, Tomotaka Tanaka, Yuriko Nakaoku, Hiroyuki Ishiyama, Soichiro Abe, Takehito Kuroda, Shinsaku Nakazawa, Chikage Kakuta, Katsuhiro Omae, Kenta Tanaka, Manabu Minami, Yoshiaki Morita, Tetsuya Fukuda, Akihiro Shindo, Takakuni Maki, Kazuo Kitamura, Hidekazu Tomimoto, Toshihiko Aso, Masafumi Ihara
BACKGROUND: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), the most common form of hereditary cerebral small vessel disease (SVD), currently lacks disease-modifying treatments. Adrenomedullin (AM), a vasoactive peptide with angiogenic, vasodilatory, anti-inflammatory, and anti-oxidative properties, shows potential effects on the neuro-glial-vascular unit. OBJECTIVE: The AdrenoMedullin for CADASIL (AMCAD) study aims to assess the efficacy and safety of AM in patients with CADASIL...
2024: Cerebral circulation—cognition and behavior