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https://www.readbyqxmd.com/read/29345240/polymeric-bioresorbable-coronary-scaffolds-the-hype-is-over-but-the-dream-lives-on
#1
Stylianos A Pyxaras, William Wijns
No abstract text is available yet for this article.
January 20, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29340853/do-bioresorbable-polyesters-have-antimicrobial-properties
#2
Lukas Gritsch, Christopher Lovell, Wolfgang H Goldmann, Aldo R Boccaccini
Biodegradable and bioresorbable polyesters (BBPEs) are a widespread class of aliphatic polymers with a plethora of applications in the medical field. Some reports speculate that these polymers have intrinsic antibacterial activity as a consequence of their acidic degradation by-products. The release of organic acids as a result of the hydrolytic degradation of BBPEs in vivo and the resulting pH drop could be an effective inhibitor of the growth of pathogens in the local environment adjacent to BBPE-based devices...
January 16, 2018: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29339714/stent-thrombosis-in-patients-with-drug-eluting-stents-and-bioresorbable-vascular-scaffolds-the-feared-complication
#3
Laura S Kerkmeijer, Erhan Tenekecioglu, Joanna J Wykrzykowska
The percutaneous coronary intervention has undergone rapid evolution over the last 40 years and has become one of the most widely performed medical procedures. The introduction of intracoronary stents improved the safety and efficacy of percutaneous coronary intervention. But with the advent of stenting, a new potentially fatal enemy emerged: stent thrombosis. Ever since, adjunct pharmacological therapy, stent technique and technology have been adjusted to reduce the risk of stent thrombosis. The aim of the present article is to provide an overview of past, present and future aspects of percutaneous intervention in relation to stent thrombosis...
January 15, 2018: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29332307/scaffold-thrombosis-following-implantation-of-the-absorb-bvs-in-routine-clinical-practice-insight-into-possible-mechanisms-from-optical-coherence-tomography
#4
Robin P Kraak, Alexandre H Kajita, Hector M Garcia-Garcia, Jose P S Henriques, Jan J Piek, E Karin Arkenbout, René J van der Schaaf, Jan G P Tijssen, Robbert J de Winter, Joanna J Wykrzykowska
OBJECTIVES: To identify potential underlying mechanisms of early and (very) late scaffold thrombosis (ScT) by optical coherence tomography (OCT), in a frame-by-frame analysis. BACKGROUND: The absorb scaffold is associated with an increased risk of ScT compared with metallic stents. Several potential causes of bioresorbable ScT have been identified, however the precise etiology still remains unclear. METHODS: Between February 2013 and February 2016, 13 patients presenting with definite ScT underwent OCT imaging...
January 14, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29327860/bioresorbable-scaffolds-versus-metallic-stents-in-routine-pci
#5
Robin P Kraak, Joanna J Wykrzykowska
No abstract text is available yet for this article.
November 2, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29327859/bioresorbable-scaffolds-versus-metallic-stents-in-routine-pci
#6
Ron Waksman
No abstract text is available yet for this article.
November 2, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29327858/bioresorbable-scaffolds-versus-metallic-stents-in-routine-pci
#7
Corrado Tamburino, Piera Capranzano
No abstract text is available yet for this article.
November 2, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29327857/bioresorbable-scaffolds-versus-metallic-stents-in-routine-pci
#8
Gian-Battista Danzi, Raffaele Piccolo
No abstract text is available yet for this article.
November 2, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29326154/what-happened-to-the-bioresorbable-scaffold-concept-black-tide-or-chernobyl
#9
EDITORIAL
Antoine Lafont, Marco G Mennuni
No abstract text is available yet for this article.
January 2018: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29326152/decision-analytic-markov-model-weighting-expected-benefits-and-current-limitations-of-first-generation-bioresorbable-vascular-scaffolds-implications-for-manufacturers-and-next-device-iterations
#10
Davide Capodanno, Sergio Buccheri, Sara Romano, Piera Capranzano, Bruno Francaviglia, Corrado Tamburino
BACKGROUND: Relative benefits of bioresorbable vascular scaffolds (BVS) compared with everolimus-eluting stents (EES) are expected to accrue after complete bioresorption. METHODS AND RESULTS: We built a decision analytic Markov model comparing BVS and EES for a contemporary percutaneous coronary intervention population. Procedure-related morbidity and outcome data from the available literature were used to derive model probabilities. The net benefit of BVS and EES was estimated in terms of quality-adjusted life expectancy...
January 2018: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29322768/identification-of-novel-inks-for-3d-printing-using-high-throughput-screening-bioresorbable-photocurable-polymers-for-controlled-drug-delivery
#11
Iria Louzao, Britta Koch, Vincenzo Taresco, Laura Ruiz Cantu, Derek J Irvine, Clive J Roberts, Christopher J Tuck, Cameron Alexander, Richard J M Hague, Ricky D Wildman, Morgan Russell Alexander
A robust discovery methodology is presented to identify novel biomaterials suitable for 3D printing. Currently the application of Additive Manufacturing is limited by the availability of functional inks, especially in the area of biomaterials-this method tackles this problem for the first time allowing hundreds of formulations to be readily assessed. Several functional properties, including the release of an antidepressive drug (paroxetine), cytotoxicity and printability are screened for 253 new ink formulations in a high-throughput format as well as mechanical properties...
January 11, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29322695/bioresorbable-scaffolds-in-coronary-intervention-unmet-needs-and-evolution
#12
REVIEW
Davide Capodanno
Bioresorbable scaffolds (BRS) represent a novel paradigm in the 40-year history of interventional cardiology. Restoration of cyclic pulsatility and physiologic vasomotion, adaptive vascular remodeling, plaque regression, and removal of the trigger for late adverse events are expected BRS benefits over current metallic drug-eluting stents. However, first-generation BRS devices have significant manufacturing limitations and rely on optimal implantation technique to avoid experiencing an excess of clinical events...
January 2018: Korean Circulation Journal
https://www.readbyqxmd.com/read/29321399/where-are-the-secrets-of-increased-thrombosis-and-aneurysm-formation-with-the-current-bioresorbable-vascular-scaffolds-hidden-%C3%A3-reply
#13
Jeehoon Kang, Hyo-Soo Kim
No abstract text is available yet for this article.
January 11, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29321398/where-are-the-secrets-of-increased-thrombosis-and-aneurysm-formation-with-the-current-bioresorbable-vascular-scaffolds-hidden
#14
Nicholas G Kounis, Ioanna Koniari, Grigorios Tsigkas, George D Soufras, George Hahalis
No abstract text is available yet for this article.
January 11, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29314648/polycaprolactone-facial-volume-restoration-of-a-46-year-old-asian-women-a-case-report
#15
Shang-Li Lin
A 46-year-old Asian women was treated with a next-generation bioresorbable biostimulatory polycaprolactone (PCL)-based dermal filler to restore facial volume loss. Before- and after (12 weeks of follow-up)-treatment photographs were analyzed and compared. In addition, before- and after-treatment contour images were recorded using the Vectra® XT 3D imaging system (Canfield Scientific, Inc.). Improvement of facial volume in multiple tissue layers was observed at 4 and 12 weeks of follow-up. Total facial rejuvenation to correct descending soft tissue with a PCL-based dermal filler was achieved through volume restoration in multiple tissue layers of the face...
January 4, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29310720/direct-comparison-of-coronary-bare-metal-vs-drug-eluting-stents-same-platform-different-mechanics
#16
Wolfram Schmidt, Peter Lanzer, Peter Behrens, Christoph Brandt-Wunderlich, Alper Öner, Hüseyin Ince, Klaus-Peter Schmitz, Niels Grabow
BACKGROUND: Drug-eluting stents (DES) compared to bare metal stents (BMS) have shown superior clinical performance, but are considered less suitable in complex cases. Most studies do not distinguish between DES and BMS with respect to their mechanical performance. The objective was to obtain mechanical parameters for direct comparison of BMS and DES. METHODS: In vitro bench tests evaluated crimped stent profiles, crossability in stenosis models, elastic recoil, bending stiffness (crimped and expanded), and scaffolding properties...
January 8, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/29303807/mucus-microbiome-of-anastomotic-tissue-during-surgery-has-predictive-value-for-colorectal-anastomotic-leakage
#17
Jasper B van Praagh, Marcus C de Goffau, Ilsalien S Bakker, Harry van Goor, Hermie J M Harmsen, Peter Olinga, Klaas Havenga
OBJECTIVE: The aim of the present study is to investigate the association of gut microbiota, depending on treatment method, with the development of colorectal anastomotic leakage (AL). BACKGROUND: AL is a major cause for morbidity and mortality after colorectal surgery, but the mechanism behind this complication still is not fully understood. METHODS: Bacterial DNA was isolated from 123 "donuts" of patients where a stapled colorectal anastomosis was made and was analyzed using 16S MiSeq sequencing...
January 4, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29285611/process-induced-degradation-of-bioresorbable-pdlga-in-bone-tissue-scaffold-production
#18
H Little, S A Clarke, E Cunningham, F Buchanan
Process-induced degradation of clinically relevant resorbable polymers was investigated for two thermal techniques, filament extrusion followed by fused deposition modelling (FDM). The aim was to develop a clear understanding of the relationship between temperature, processing time and resultant process-induced degradation. This acts to address the current knowledge gap in studies involving thermal processing of resorbable polymers. Poly(DL-lactide-co-glycolide) (PDLGA) was chosen for its clinically relevant resorption properties...
December 28, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29284158/optimized-polymer-coating-for-magnesium-alloy-based-bioresorbable-scaffolds-for-long-lasting-drug-release-and-corrosion-resistance
#19
Wei Xu, Kai Yagoshi, Yuki Koga, Makoto Sasaki, Takuro Niidome
Magnesium (Mg) alloy-based bioresorbable scaffolds (BRSs) are attracting interest as next-generation stents. However, because medical Mg alloy materials degrade relatively quickly in physiological media, surface corrosion protection via biodegradable polymer coatings is important for clinical applications. Herein, the influence of biodegradable polymer coatings on the BRS corrosion was investigated. First, elution of the drug sirolimus (SRL) from various biodegradable polymers was estimated, including poly(d,l-lactic acid) (PDLLA), poly(d,l-lactic acid-co-ε-caprolactone) (PLCL) and poly(ε-caprolactone) (PCL)...
December 19, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29281608/a-new-generation-of-drug-eluting-stents-indications-and-outcomes-of-bioresorbable-vascular-scaffolds
#20
REVIEW
Ron Waksman
Drug-eluting stents (DES) are increasingly being used as a less invasive alternative to coronary artery bypass grafting. Early generation DES had durable polymers that provided acceptable efficacy outcomes but had high rates of stent thrombosis leading to myocardial infarction and death. Second-generation DES have improved outcomes by reducing stent thrombosis and recurrent stenosis. Newer DES with biodegradable polymers have similar efficacy as second-generation DES, but have higher rates of stent thrombosis...
December 2017: Cleveland Clinic Journal of Medicine
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