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https://www.readbyqxmd.com/read/28228292/a-fresh-look-at-bioresorbable-scaffold-technology-intuition-pumps
#1
EDITORIAL
Sundeep Mishra
Bioresorbable scaffolds (BRS) are a new enticing treatment option in coronary interventions. Absorb BVS™ Is the most widely used and researched polymer based BRS, eluting everolimus. However currently it has several technical limitations; low radial support, larger strut size, poor visualization, poor deliverability and complex implantation technique. Magnesium based BRS are an alternate but they are also limited not only by lower radial support and poor visualization but also earlier bio-absorption. Material processing: blow-molding, annealing, polymer orientation, change in composition and use of higher molecular weight polymer, as well new polymers like tyrosine or salicyclate analogs and even hybrid (polymer and metallic) combined with intelligent cell design has led to evolution of BRS technology...
January 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28226727/surgical-fiducial-segmentation-and-tracking-for-pose-estimation-based-on-ultrasound-b-mode-images
#2
Lei Chen, Nathanael Kuo, Fereshteh Aalamifar, David Narrow, Devin Coon, Jerry Prince, Emad M Boctor, Lei Chen, Nathanael Kuo, Fereshteh Aalamifar, David Narrow, Devin Coon, Jerry Prince, Emad M Boctor, David Narrow, Emad M Boctor, Devin Coon, Lei Chen, Jerry Prince, Nathanael Kuo, Fereshteh Aalamifar
Doppler ultrasound is a non-invasive diagnostic tool for the quantitative measurement of blood flow. However, given that it provides velocity data that is dependent on the location and angle of measurement, repeat measurements to detect problems over time may require an expert to return to the same location. We therefore developed an image-guidance system based on ultrasound B-mode images that enables an inexperienced user to position the ultrasound probe at the same site repeatedly in order to acquire a comparable time series of Doppler readings...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28221044/tunable-volumetric-density-and-porous-structure-of-spherical-poly-%C3%A9-caprolactone-microcarriers-as-applied-in-human-mesenchymal-stem-cell-expansion
#3
Jian Li, Alan Tin-Lun Lam, Jessica Pei Wen Toh, Shaul Reuveny, Steve Kah-Weng Oh, William R Birch
Polymeric microspheres may serve as microcarrier matrices, for the expansion of anchorage-dependent stem cells. They require surface properties that both promote initial cell adhesion and the subsequent spreading of cells, which is a prerequisite for successful expansion. When implemented in a three-dimensional culture environment, under agitation, their suspension under low shear rates depends on the microcarriers having a modest negative buoyancy, with a density of 1.02-1.05 g/cm(3). Bioresorbable polycaprolactone (PCL), with a density of 1...
February 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28218604/everolimus-eluting-bioresorbable-vascular-scaffold-for-treatment-of-complex-chronic-total-occlusions
#4
Jiang Ming Fam, Soledad Ojeda, Roberto Garbo, Azeem Latib, Alessio La Manna, Beatriz Vaquerizo, Marouane Boukhris, Georgios J Vlachojannis, Robert Jan van Geuns, Babu Ezhumalai, Hiroyoshi Kawamoto, Jors van der Sijde, Cordula Felix, Manuel Pan, Roberta Serdoz, Giacomo Giovanni Boccuzzi, Marcella De Paolis, Gennaro Sardella, Corrado Tamburino, Pieter C Smits, Carlo Di Mario, Ashok Seth, Antonio Serra, Antonio Colombo, Patrick Serruys, Alfredo R Galassi, Felix Zijlstra, Nicolas M van Mieghem, Roberto Diletti
AIMS: Bioresorbable vascular scaffolds (BVS) represent a novel therapeutic option for the treatment of coronary artery diseases. The objective of this study is to evaluate the feasibility of BVS implantation in complex chronic total occlusions (CTO). METHODS AND RESULTS: The present report is a multi-centre registry evaluating results after BVS deployment in challenging CTO lesions defined as J-CTO score≥2 (difficult or very difficult). A total of 105 patients were included in the present analysis...
February 21, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28218485/mechanically-milled-irregular-zinc-nanoparticles-for-printable-bioresorbable-electronics
#5
Bikram K Mahajan, Xiaowei Yu, Wan Shou, Heng Pan, Xian Huang
Bioresorbable electronics is predominantly realized by complex and time-consuming anhydrous fabrication processes. New technology explores printable methods using inks containing micro- or nano-bioresorbable particles (e.g., Zn and Mg). However, these particles have seldom been obtained in the context of bioresorbable electronics using cheap, reliable, and effective approaches with limited study on properties essential to printable electronics. Here, irregular nanocrystalline Zn with controllable sizes and optimized electrical performance is obtained through ball milling approach using polyvinylpyrrolidone (PVP) as a process control agent to stabilize Zn particles and prevent cold welding...
February 20, 2017: Small
https://www.readbyqxmd.com/read/28216214/everolimus-versus-novolimus-eluting-bioresorbable-scaffolds-for-the-treatment%C3%A2-of-coronary-artery-disease-a-matched-comparison
#6
Jens Wiebe, Oliver Dörr, Hanna Ilstad, Oliver Husser, Christoph Liebetrau, Niklas Boeder, Timm Bauer, Helge Möllmann, Adnan Kastrati, Christian W Hamm, Holger M Nef
OBJECTIVES: The purpose of this study was to compare the 1-year outcome of everolimus-eluting bioresorbable scaffolds (eBRS) and Novolimus-eluting bioresorbable scaffolds (nBRS) in patients undergoing percutaneous coronary intervention in a real-life clinical practice scenario. BACKGROUND: eBRS and nBRS are available and have been proved safe for coronary artery stenting in well-selected patients. METHODS: Consecutive patients who underwent bioresorbable scaffold implantation were evaluated retrospectively via 2:1 propensity matching...
February 9, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28211364/antibacterial-effect-of-novel-biodegradable-and-bioresorbable-plda-mg-composites
#7
M C Fernández-Calderón, S C Cifuentes, M A Pacha-Olivenza, A M Gallardo-Moreno, L Saldaña, J L González-Carrasco, M T Blanco, N Vilaboa, M L González-Martín, C Pérez-Giraldo
Polylactic acid/Mg composites have been recently proposed for biodegradable osteosynthesis devices because, with regards to the neat polymer, they combine an enhanced biocompatibility and bioactivity with better mechanical properties, particularly creep strength. A question still arises about their bacterial behavior. For this purpose, composites of poly-L-D-lactic acid (PLDA) loaded with 1 and 10 wt.% of Mg microparticles were evaluated using Staphylococcus epidermidis, with special emphasis on the study of bacterial adhesion and biofilm formation...
February 17, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28185417/left-main-coronary-angioplasty-of-a-9-year-old-child-with-bioresorable-vascular-scaffold
#8
Hasmukh Ravat, Swati Garekar, Vishal Changela
Familial hypercholesterolemia is an autosomal dominant disorder due to mutations in the low-density lipoprotein receptor gene, characterized by skin and tendon xanthomas, xanthelasmas, and increased risk of premature coronary artery disease. Here, we report a case of 9-year-old girl who presented with angina and dyspnoea on exertion with xanthomas and an elevated serum cholesterol and triglyceride. She had severe stenosis of the left main coronary artery (LMCA) requiring angioplasty and placement of Bioresorbable vascular scaffold (BVS)...
February 10, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28181101/preparation-of-hydroxyapatite-collagen-injectable-bone-paste-with-an-anti-washout-property-utilizing-sodium-alginate-part-1-influences-of-excess-supplementation-of-calcium-compounds
#9
Taira Sato, Masanori Kikuchi, Mamoru Aizawa
The anti-washout property, viscosity, and cytocompatibility to an osteoblastic cell line, MG-63, of anti-washout pastes were investigated. Mixing a hydroxyapatite/collagen bone-like nanocomposite (HAp/Col), an aqueous solution of sodium alginate (Na-Alg), which is a paste hardening and lubricant agent, and supplementation of calcium carbonate or calcium citrate (Ca-Cit) as a calcium resource for the hardening reaction realized an injectable bone paste. Adding Ca-Cit at a concentration greater than eight times the Ca(2+) ion concentration to Na-Alg improved the anti-washout property...
March 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28177449/coronary-bioresorbable-vascular-scaffold-radiopaque-marker-embolization
#10
Carlos Collet, Pannipa Suwannasom, Manuel Almeida, Yoshinobu Onuma, Patrick W Serruys
No abstract text is available yet for this article.
February 8, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28176192/effect-of-the-up-front-heat-treatment-of-gelatin-particles-dispersed-in-calcium-phosphate-cements-on-the-in-vivo-material-resorption-and-concomitant-bone-formation
#11
Shoko Yamamoto, Yuta Matsushima, Yoshitaka Kanayama, Azusa Seki, Haruya Honda, Hidero Unuma, Yasuo Sakai
Calcium phosphate cements (CPCs), consisting of a mixture of calcium phosphate powders and setting liquid, have been widely used in orthopedic applications. One of the drawbacks of CPCs is their poor resorbability in the living body, which hinders substitution with natural bones. One of the strategies to facilitate the resorption of CPCs is the incorporation of bioresorbable or water-soluble pore-generating particles (porogens), such as gelatin, in the CPC matrices. In spite of numerous reports, however, little is known about the effect of the dissolution/resorption rate of the porogens on concomitant bone regeneration...
March 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28171812/immiscible-poly-lactic-acid-poly-%C3%AE%C2%B5-caprolactone-for-temporary-implants-compatibility-and-cytotoxicity
#12
Pablo F M Finotti, Lidiane C Costa, Ticiana S O Capote, Raquel M Scarel-Caminaga, Marcelo A Chinelatto
This manuscript focuses on the effect of the addition of a low molecular weight triblock copolymer derived from ε-caprolactone and tetrahydrofuran (CT) on the compatibility and cytotoxicity of immiscible poly(lactic acid) (PLA) and poly(ε-caprolactone) (PCL) blends. Binary and tertiary PLA/PCL blends were prepared by melt mixing in a twin-screw extruder and their morphological, mechanical and thermal behaviors were investigated by scanning electron microscopy (SEM), tensile and Izod impact test, dynamic mechanical analysis (DMA) and differential scanning calorimetry (DSC)...
January 31, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28164433/coronary-artery-aneurysm-after-implantation-of-a-bioresorbable-vascular-scaffold-case-report-and-literature-review
#13
Su-Kiat Chua, Jun-Jack Cheng
A 55-year-old man underwent successful percutaneous coronary intervention for the middle left circumflex artery with a 3.5 × 28-mm bioresorbable vascular scaffold (BVS). At 18 months, follow-up coronary angiography showed ectatic change with aneurysm formation over the BVS. Optical coherence tomography revealed absence of strut continuity at the aneurysm site, in the middle of the BVS. A literature review identified nine patients with intrascaffold aneurysm, including the present patient, which developed 6-32 months after BVS implantation...
February 6, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28158421/fate-of-post-procedural-malapposition-of-everolimus-eluting-polymeric-bioresorbable-scaffold-and-everolimus-eluting-cobalt-chromium-metallic-stent-in-human-coronary-arteries-sequential-assessment-with-optical-coherence-tomography-in-absorb-japan-trial
#14
Yohei Sotomi, Yoshinobu Onuma, Jouke Dijkstra, Yosuke Miyazaki, Ken Kozuma, Kengo Tanabe, Jeffrey J Popma, Robbert J de Winter, Patrick W Serruys, Takeshi Kimura
No abstract text is available yet for this article.
January 30, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28145045/intraluminal-bioresorbable-vascular-scaffold-dismantling-with-aneurysm-formation-leading-to-very-late-thrombosis
#15
Amisha Patel, Tamim Nazif, Gregg W Stone, Ziad A Ali
Coronary artery aneurysm formation has been described in patients after the placement of first-generation drug-eluting stents (DES), but is less common with newer generation metallic stents. In contrast, coronary artery aneurysm formation may be more common with the use of bioresorbable vascular scaffolds (BVS) due to the frequent formation of evaginations in the arterial wall seen with BVS. In this article, we describe a unique case of BVS dismantling and thrombus formation leading to an acute coronary syndrome thirty-two months after initial BVS placement...
February 1, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28134094/outcome-after-long-segment-stenting-with-everolimus-eluting-bioresorbable-scaffolds-focusing-on-the-concept-of-overlapping-implantation
#16
Jens Wiebe, Oliver Dörr, Christoph Liebetrau, Timm Bauer, Eva Wilkens, Hanna Ilstad, Niklas Boeder, Albrecht Elsässer, Helge Möllmann, Christian W Hamm, Holger M Nef
INTRODUCTION AND OBJECTIVES: The implantation of bioresorbable scaffolds (BRS) is an emerging technique used in percutaneous coronary interventions. Their application has been extended to more complex lesions, although evidence is only available for simple lesions. The present study evaluated scaffold implantation in long lesions, focusing on overlapping scaffolds. METHODS: We retrospectively analyzed all consecutive patients eligible for stenting with everolimus-eluting poly-L-lactic acid-based BRS with a minimum total scaffold length of 28mm, irrespective of the number of BRS used...
December 2016: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28132761/restenosis-after-everolimus-eluting-vascular-scaffolding-angiographic-and-optical-coherence-tomography-characterization
#17
Jorge Chavarría, Javier Suárez de Lezo, Soledad Ojeda, Manuel Pan, José Segura, Francisco Mazuelos, Simona Espejo, José López, Miguel Romero, José Suárez de Lezo
INTRODUCTION AND OBJECTIVES: Coronary restenosis after bioresorbable vascular scaffold (BVS) implantation is infrequent and little information is available on the main characteristics of these lesions. The aim of this study was to assess restenotic lesions by using optical coherence tomography (OCT). METHODS: We studied 330 patients with coronary artery disease who received 398 BVS to treat 380 lesions. These patients were clinically and angiographically evaluated at follow-up and OCT was carried out on detection of restenosis...
October 27, 2016: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28130134/nanoceramics-on-osteoblast-proliferation-and-differentiation-in-bone-tissue-engineering
#18
REVIEW
Sai Nievethitha S, Subhapradha N, Saravanan D, Selvamurugan N, Wei-Bor Tsai, Srinivasan N, Murugesan R, Moorthi A
Bone, a highly dynamic connective tissue, consist of a bioorganic phase comprising osteogenic cells and proteins which lies over an inorganic phase predominantly made of CaPO4 (biological apatite). Injury to bone can be due to mechanical, metabolic or inflammatory agents also owing pathological conditions like fractures, osteomyelitis, osteolysis or cysts may arise in enameloid, chondroid, cementum, or chondroid bone which forms the intermediate tissues of the body. Bone tissue engineering (BTE) applies bioactive scaffolds, host cells and osteogenic signals for restoring damaged or diseased tissues...
January 24, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28120759/-when-textiles-help-your-recovery
#19
Bernard Martel, Christine Campagne, Nemeshwaree Behary Massika
Textiles are widely used in the biomedical domain, particularly in wound dressings or as implantable devices for strengthening or even replacing some damaged organs. Nowadays they present more and more sophisticated functionalities contributing to the healing process, to the organs regeneration, and fight against infection or thrombosis. Advanced spinning technologies of biostable or bioresorbable polymers and surface treatment technologies are often used, as well as nanotechnologies, to implement two main strategies for development of bio-active textiles...
January 2017: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/28119252/what-determines-long-term-outcomes-using-fully-bioresorbable-scaffolds-the-device-the-operator-or-the-lesion
#20
Kyohei Yamaji, Lorenz Räber, Stephan Windecker
No abstract text is available yet for this article.
January 26, 2017: EuroIntervention
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