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Post-stroke Depression

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https://www.readbyqxmd.com/read/28615993/resveratrol-protects-against-icv-collagenase-induced-neurobehavioral-and-biochemical-deficits
#1
Navdeep Singh, Yashika Bansal, Ranjana Bhandari, Lovish Marwaha, Raghunath Singh, Kanwaljit Chopra, Anurag Kuhad
BACKGROUND: Indeed, intracerebral hemorrhage (ICH) account for only 15% of all strokes but it is one of the most devastating subtype of stroke associated with behavioral, cognitive and neurological deficits. The primary cause of neurological deficits in ICH is the hematoma growth, generation of free radicals, inflammatory cytokines and exhausting endogenous anti-oxidant machinery. It has been found that neuroinflammation following ICH leads to exaggeration of hallmarks of ICH. With this background, the study was aimed to evaluate the protective effect of resveratrol (RSV) in intracerebroventricular (ICV) collagenase (COL) induced neurological deficits in rats...
2017: Journal of Inflammation
https://www.readbyqxmd.com/read/28609387/long-term-sertraline-treatment-and-depression-effects-on-carotid-artery-atherosclerosis-in-premenopausal-female-primates
#2
Marnie G Silverstein-Metzler, Jamie N Justice, Susan E Appt, Leanne Groban, Dalane W Kitzman, John Jeffrey Carr, Thomas C Register, Carol A Shively
OBJECTIVE: Atherosclerosis developed during premenopausal years predicts postmenopausal atherosclerosis burden. Selective serotonin reuptake inhibitor (SSRI) antidepressants, recently approved for hot flushes, have been associated with increased ischemic stroke risk in several observational studies; however, effects on carotid artery atherosclerosis, a strong predictor of future vascular events, are unknown. METHODS: The effects of chronic administration of a commonly prescribed SSRI, sertraline HCl, on atherosclerosis in the carotid artery was assessed in a placebo-controlled, longitudinal, randomized study of premeonopausal depressed and nondepressed cynomolgus monkeys (Macaca fascicularis; n = 42)...
June 12, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28600933/malondialdehyde-a-novel-predictive-biomarker-for-post-stroke-depression
#3
Zhihua Liu, Zhuoying Zhu, Jiyun Zhao, Wenwei Ren, Yan Cai, Qiongzhang Wang, Xiaoqian Luan, Kai Zhao, Jincai He
BACKGROUND: There is evidence that stroke is accompanied by oxidative stress. However, the links between oxidative stress and depression in stroke patients are poorly understood. This study examines whether post-stroke depression (PSD) is associated with oxidative stress. METHODS: Overall, 216 acute stroke patients were consecutively recruited and followed up for 1 month. Blood specimens were collected within 24h after admission and measured for the following oxidative stress biomarkers: malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX)...
May 10, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28583576/administration-of-huperzine-a-exerts-antidepressant-like-activity-in-a-rat-model-of-post-stroke-depression
#4
Yuan Du, Haiyue Liang, Leiming Zhang, Fenghua Fu
Post-stroke depression (PSD) is the most common mood disorder following a stroke, and is also the main factor limiting recovery and rehabilitation in stroke patients. The present study was aimed to investigate whether Huperzine A (HupA) has antidepressant-like activity in a rat model of PSD, which was developed by middle cerebral artery occlusion followed by an 18-day chronic unpredictable mild stress in conjunction with isolation rearing. The sucrose preference and forced swim tests were used to assess depression-like behavior...
July 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28566545/long-term-unmet-needs-and-associated-factors-in-stroke-or-tia-survivors-an-observational-study
#5
Muideen T Olaiya, Dominique A Cadilhac, Joosup Kim, Mark R Nelson, Velandai K Srikanth, Nadine E Andrew, Christopher F Bladin, Richard P Gerraty, Sharyn M Fitzgerald, Thanh Phan, Judith Frayne, Amanda G Thrift
OBJECTIVE: To extensively investigate long-term unmet needs in survivors of stroke or TIA and to identify factors associated with these unmet needs. METHODS: Community-dwelling adults were invited to participate in a survey ≥2 years after discharge for stroke/TIA. Unmet needs were assessed across 5 domains: activities and participation, environmental factors, body functions, post-acute care, and secondary prevention. Factors associated with unmet needs were determined with multivariable negative binomial regression...
May 31, 2017: Neurology
https://www.readbyqxmd.com/read/28566265/computerized-cognitive-behavioral-therapy-to-treat-emotional-distress-after-stroke-a-feasibility-randomized-controlled-trial
#6
Sara K Simblett, Matthew Yates, Adam P Wagner, Peter Watson, Fergus Gracey, Howard Ring, Andrew Bateman
BACKGROUND: Depression and anxiety are common complications following stroke. Symptoms could be treatable with psychological therapy, but there is little research on its efficacy. OBJECTIVES: The aim of this study was to investigate (1) the acceptability and feasibility of computerized cognitive behavioral therapy (cCBT) to treat symptoms of depression and anxiety and (2) a trial design for comparing the efficacy of cCBT compared with an active comparator. METHODS: Of the total 134 people screened for symptoms of depression and anxiety following stroke, 28 were cluster randomized in blocks with an allocation ratio 2:1 to cCBT (n=19) or an active comparator of computerized cognitive remediation therapy (cCRT, n=9)...
May 31, 2017: JMIR Mental Health
https://www.readbyqxmd.com/read/28566168/management-of-post-stroke-depression-in-the-middle-east-and-north-africa-too-little-is-known
#7
REVIEW
M Ihsan Kaadan, Mary Jo Larson
Stroke is among the most common disabilities among adults and most stroke victims live in developing countries. However, little is known about services delivered in these countries for post-stroke depression, a common comorbidity that influences functional outcomes of stroke. In this paper, a physician from Syria reviews the literature on post-stroke depression among patients living in countries of the Middle East and North Africa region in order to examine whether current practices can be improved. Studies of prevalence were found in six of the region's countries and only four studies described interventions for stroke patients with clinical depression...
July 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28556875/nonpharmacological-treatments-for-post-stroke-depression-an-integrative-review-of-the-literature
#8
Niloufar Niakosari Hadidi, Roberta L Huna Wagner, Ruth Lindquist
Stroke is the fifth leading cause of death and the number one cause of long-term disability. Seventy-five percent of annual stroke victims are older than 65. Post-stroke depression (PSD) is a common consequence of stroke, with the estimated prevalence ranging from 25% to 79%. Although several studies have investigated the impact of pharmacological interventions on PSD, there is a significant gap in knowledge regarding the efficacy of nonpharmacological measures for treatment of PSD. The purpose of the current integrative literature review was to synthesize the state of knowledge on selected nonpharmacological treatments for PSD and present findings regarding the efficacy of investigated treatments...
May 30, 2017: Research in Gerontological Nursing
https://www.readbyqxmd.com/read/28549087/thalamic-alterations-remote-to-infarct-appear-as-focal-iron-accumulation-and-impact-clinical-outcome
#9
Grégory Kuchcinski, Fanny Munsch, Renaud Lopes, Antoine Bigourdan, Jason Su, Sharmila Sagnier, Pauline Renou, Jean-Pierre Pruvo, Brian K Rutt, Vincent Dousset, Igor Sibon, Thomas Tourdias
Thalamic alterations have been observed in infarcts initially sparing the thalamus but interrupting thalamo-cortical or cortico-thalamic projections. We aimed at extending this knowledge by demonstrating with in vivo imaging sensitive to iron accumulation, one marker of neurodegeneration, that (i) secondary thalamic alterations are focally located in specific thalamic nuclei depending on the initial infarct location; and (ii) such secondary alterations can contribute independently to the long-term outcome. To tackle this issue, 172 patients with an infarct initially sparing the thalamus were prospectively evaluated clinically and with magnetic resonance imaging to quantify iron through R2* map at 24-72 h and at 1-year follow-up...
May 25, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28545791/the-combination-of-plasma-glutamate-and-physical-impairment-after-acute-stroke-as-a-potential-indicator-for-the-early-onset-post-stroke-depression
#10
Lei-Yu Geng, Fang-Yuan Qian, Jun-Feng Qian, Zhi-Jun Zhang
OBJECTS: The present study aimed to investigate the relationship of plasma glutamate levels with the early-onset of post-stroke depression (PSD) and to further explore the prognostic value of plasma glutamate combined with clinical characteristics for the early-onset PSD in the acute ischemic stroke patients. METHODS: Seventy-four patients who admitted to the hospital within 24h of acute ischemic stroke were consecutively recruited and followed up for 2weeks. The Beck Depression Inventory (BDI) and 17-item Hamilton Depression Rating Scale (HAMD-17) were used to screen for depressive symptoms 14days after stroke...
May 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28535081/advances-in-antidepressants-for-treating-post-stroke-depression
#11
Stefano Paolucci
Post-stroke depression (PSD) is a common and serious complication after stroke, occurring in nearly one third of stroke survivors, and affecting mortality rate, functional outcome, rehabilitation results and quality of life. However, in the common clinical practice only a minority of patients are properly treated. A relatively small number of scientific reports are available on clinical usefulness and safety of antidepressants (ADs) in PSD. Areas covered: This report provides an updated review about pharmacological state of art of PSD, including efficacy and safety of different drugs and their role on prevention, treatment and functional outcome...
June 5, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28533447/correction-to-in-hospital-risk-prediction-for-post-stroke-depression-development-and-validation-of-the-post-stroke-depression-prediction-scale
#12
(no author information available yet)
No abstract text is available yet for this article.
June 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28528818/patellar-tendon-vibration-reduces-the-increased-facilitation-from-quadriceps-to-soleus-in-post-stroke-hemiparetic-individuals
#13
Eric Maupas, Joseph-Omer Dyer, Sibele de Andrade Melo, Robert Forget
BACKGROUND: Stimulation of the femoral nerve in healthy people can facilitate soleus H-reflex and electromyography (EMG) activity. In stroke patients, such facilitation of transmission in spinal pathways linking the quadriceps and soleus muscles is enhanced and related to co-activation of knee and ankle extensors while sitting and walking. Soleus H-reflex facilitation can be depressed by vibration of the quadriceps in healthy people, but the effects of such vibration have never been studied on the abnormal soleus facilitation observed in people after stroke...
May 18, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28527083/shared-mechanisms-of-epilepsy-migraine-and-affective-disorders
#14
Davide Zarcone, Simona Corbetta
Since the nineteenth century several clinical features have been observed in common between migraine and epilepsy (such as episodic attacks, triggering factors, presence of aura, frequent familiarity), but only in recent years researchers have really engaged in finding a common pathogenic mechanism. From studies of disease incidence, we understand how either migraine among patients with epilepsy or epilepsy among migraine patients are more frequent than in the general population. This association may result from a direct causality, by the same environmental risk factors and/or by a common genetic susceptibility...
May 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28525836/arterial-spin-labelling-shows-functional-depression-of-non-lesion-tissue-in-chronic-wernicke-s-aphasia
#15
Holly Robson, Karsten Specht, Helen Beaumont, Laura M Parkes, Karen Sage, Matthew A Lambon Ralph, Roland Zahn
Behavioural impairment post-stroke is a consequence of structural damage and altered functional network dynamics. Hypoperfusion of intact neural tissue is frequently observed in acute stroke, indicating reduced functional capacity of regions outside the lesion. However, cerebral blood flow (CBF) is rarely investigated in chronic stroke. This study investigated CBF in individuals with chronic Wernicke's aphasia (WA) and examined the relationship between lesion, CBF and neuropsychological impairment. Arterial spin labelling CBF imaging and structural MRIs were collected in 12 individuals with chronic WA and 13 age-matched control participants...
November 10, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28521579/cognitive-behavioural-therapy-for-post-stroke-fatigue-and-sleep-disturbance-a-pilot-randomised-controlled-trial-with-blind-assessment
#16
Sylvia Nguyen, Dana Wong, Adam McKay, Shantha M W Rajaratnam, Gershon Spitz, Gavin Williams, Darren Mansfield, Jennie L Ponsford
The objective of this study was to evaluate the effectiveness of individual cognitive behavioural therapy (CBT) for post-stroke fatigue and sleep disturbance compared to treatment as usual (TAU). In a parallel two-group pilot randomised controlled trial of 15 participants, nine were allocated to eight weekly sessions of adapted CBT and six continued usual care rehabilitation. The primary outcome was the Fatigue Severity Scale (FSS-7) at two and four months from baseline. Secondary outcomes included measures of sleep, mood and quality of life...
May 19, 2017: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/28506018/return-to-work-predictors-of-stroke-survivors-and-their-spousal-caregivers
#17
Celia H Schulz, Kyler M Godwin, Gayle I Hersch, Leslie K Hyde, Jocelyn J Irabor, Sharon K Ostwald
BACKGROUND: Return to work is an issue of concern for stroke survivors and their spouses. Ramifications may include loss of income and self-efficacy. OBJECTIVE: This study describes the return to work patterns of stroke survivors and their spousal caregivers post stroke. METHODS: One hundred fifty-nine dyads were examined for their return to work patterns at baseline (post hospital discharge) and then at 3 month intervals for one year. Relationships were determined between work and gender, age, ethnicity, education, type of insurance, type of stroke, location of stroke, motor and cognitive functional status, depression, mutuality, and life satisfaction...
2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28505996/depression-one-year-after-hemorrhagic-stroke-is-associated-with-late-worsening-of%C3%A2-outcomes
#18
Sara Stern-Nezer, Irina Eyngorn, Michael Mlynash, Ryan W Snider, Chitra Venkatsubramanian, Christine A C Wijman, Marion S Buckwalter
BACKGROUND: Poststroke depression is the most common psychiatric sequelae of stroke, and it's independently associated with increased morbidity and mortality. Few studies have examined depression after intracranial hemorrhage (ICH). OBJECTIVE: To investigate the relationship between depression, ICH and outcomes. METHODS: A substudy of the prospective Diagnostic Accuracy of MRI in Spontaneous Intracerebral Hemorrhage (DASH) study, we included 89 subjects assessed for depression 1 year after hemorrhage...
May 11, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28494456/proton-magnetic-resonance-spectroscopy-study-on-the-metabolism-changes-of-cerebellum-in-patients-with-post-stroke-depression
#19
Lei Zhang, Ru-Bo Sui
OBJECTIVE: To study the metabolic changes of cerebellum by proton magnetic resonance Spectroscopy (1H-MRS) and discuss the relationships between the cerebellar changes and depression severity in patients with post-stroke depression. METHODS AND RESULTS: Data of demographic characteristics, individual history and life style of all subjects were collected. 40 patients with stroke and 20 controls were enrolled. All groups received T1WI, T2WI, DWI and 1H-MRS examination...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28488825/a-randomized-trial-of-the-effects-of-an-aquatic-exercise-program-on-depression-anxiety-levels-and-functional-capacity-in-of-people-who-suffered-an-ischemic-stroke
#20
Felipe J Aidar, Ricardo Jacó de Oliveira, Dihogo Gama de Matos, Philip D Chilibeck, Raphael F de Souza, André L Carneiro, Victor Machado Reis
BACKGROUND: Aquatic exercise programs are used in rehabilitation and might help to reduce disability after stroke. OBJECTIVE: This was a randomized intervention trial to assess the influence of an aquatic exercise program on people suffering from depression and anxiety after ischemic stroke. METHODS: Participants were randomized to an experimental group (EG) composed of 19 individuals (51.8 ± 8.5 years; ten males and nine females), and a control group (CG) composed of 17 people (52...
May 9, 2017: Journal of Sports Medicine and Physical Fitness
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