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Post-stroke Depression

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https://www.readbyqxmd.com/read/28420284/a-systematic-review-of-rehabilitation-interventions-to-prevent-and-treat-depression-in-post-stroke-aphasia
#1
Caroline Baker, Linda Worrall, Miranda Rose, Kyla Hudson, Brooke Ryan, Leana O'Byrne
PURPOSE: Stepped psychological care is the delivery of routine assessment and interventions for psychological problems, including depression. The aim of this systematic review was to analyze and synthesize the evidence of rehabilitation interventions to prevent and treat depression in post-stroke aphasia and adapt the best evidence within a stepped psychological care framework. METHOD: Four databases were systematically searched up to March 2017: Medline, CINAHL, PsycINFO and The Cochrane Library...
April 19, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28417454/prevalence-and-predictors-of-anxiety-in-an-african-sample-of-recent-stroke-survivors
#2
A Ojagbemi, M Owolabi, R Akinyemi, O Arulogun, J Akinyemi, O Akpa, F S Sarfo, E Uvere, R Saulson, S Hurst, B Ovbiagele
OBJECTIVES: Studies considering emotional disturbances in the setting of stroke have primarily focused on depression and been conducted in high-income countries. Anxiety in stroke survivors, which may be associated with its own unique sets of risk factors and clinical parameters, has been rarely investigated in sub-Saharan Africa (SSA). We assess the characteristics of anxiety and anxiety-depression comorbidity in a SSA sample of recent stroke survivors. MATERIALS AND METHODS: We assessed baseline data being collected as part of an intervention to improve one-year blood pressure control among recent (≤1 month) stroke survivors in SSA...
April 17, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28404841/midas-modafinil-in-debilitating-fatigue-after-stroke-a-randomized-double-blind-placebo-controlled-cross-over-trial
#3
Andrew Bivard, Thomas Lillicrap, Venkatesh Krishnamurthy, Elizabeth Holliday, John Attia, Heather Pagram, Michael Nilsson, Mark Parsons, Christopher R Levi
BACKGROUND AND PURPOSE: This study aimed to assess the efficacy of modafinil, a wakefulness-promoting agent in alleviating post-stroke fatigue ≥3 months after stroke. We hypothesized that 200 mg of modafinil daily for 6 weeks would result in reduced symptoms of fatigue compared with placebo. METHODS: This single-center phase 2 trial used a randomized, double-blind, placebo-controlled, crossover design. The key inclusion criterion was a multidimensional fatigue inventory score of ≥60...
April 12, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28395524/performance-and-capacity-based-measures-of-locomotion-compared-to-impairment-based-measures-best-predicted-participation-in-individuals-with-hemiparesis-due-to-stroke
#4
Iza Faria-Fortini, Marluce L Basílio, Aline A Scianni, Christina D C M Faria, Luci F Teixeira-Salmela
PURPOSE: To determine the potential predictors of participation of individuals with post-stroke hemiparesis, taking into account modifiable variables of impairments, activity limitations, and environmental factors. METHODS: One hundred and nine individuals (58 ± 12 years; 64 men) participated in this study. Outcomes included measures of impairments (depressive symptoms: Geriatric Depression Scale and motor-based impairments: finger-to-nose test, lower extremity (LE) motor coordination test, and handgrip strength, isometric strength of the LE muscles), activity (capacity: 10-meter walking speed test and Test d'Évaluation des Membres Supérieurs de Personnes Agées; performance: locomotion and manual abilities; environmental factors (Measure of the Quality of the Environment); and participation: Assessment of Life Habits (LIFE-H 3...
April 11, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28393267/charting-the-perfect-storm-emerging-biological-interfaces-between-stress-and-stroke
#5
REVIEW
G Kronenberg, J Schöner, C Nolte, A Heinz, M Endres, Karen Gertz
A growing body of evidence demonstrates that psychosocial stress is an important and often underestimated risk factor for cardiovascular disease such as myocardial infarction and stroke. In this article, we map out major biological interfaces between stress, stress-related psychiatric disorders, and stroke, placing special emphasis on the fact that stress and psychiatric disorders may be both cause and consequence of cardiovascular disease. Apart from high-risk lifestyle habits such as smoking and lack of exercise, neuroendocrine dysregulation, alterations of the hemostatic system, increased oxidative stress, and inflammatory changes have been implicated in stress-related endothelial dysfunction...
April 9, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28387015/the-factors-related-to-early-onset-depression-after-first-stroke
#6
Kadir Karakus, Refik Kunt, Cagdas O Memis, Duygu A Kunt, Bilge Dogan, Filiz Ozdemiroglu, Levent Sevincok
BACKGROUND: The biological and psychological aspects of post-stroke depression (PSD) may vary based on the time since stroke onset. The sociodemographic and clinical correlates of early-onset PSD are not yet well understood. In the present study, we aimed to investigate the clinical correlates of early-onset depression following first stroke. We hypothesized that the severity of a stroke or disability (other than lesion characteristics) would likely be related to PSD in a sample of first stroke patients with single and unilateral lesions...
April 7, 2017: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://www.readbyqxmd.com/read/28381994/losing-without-fighting-simple-aversive-stimulation-induces-submissiveness-typical-for-social-defeat-via-the-action-of-nitric-oxide-but-only-when-preceded-by-an-aggression-priming-stimulus
#7
Jan Rillich, Paul A Stevenson
Losing a fight (social defeat) induces submissiveness and behavioral depression in many animals, but the mechanisms are unclear. Here we investigate how the social defeat syndrome can be established as a result of experiencing aversive stimuli and the roles of neuromodulators in the process. While biogenic amines and nitric oxide (NO) are associated with reduced aggression in mammals and insects, their specific actions during conflict are unknown. Although the social defeat syndrome normally results from complex interactions, we could induce it in male crickets simply by applying aversive stimuli (AS) in an aggressive context...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28380672/randomized-clinical-trial-of-deep-brain-stimulation-for-post-stroke-pain
#8
Scott F Lempka, Donald A Malone, Bo Hu, Kenneth B Baker, Alexandria Wyant, John Ozinga, Ela B Plow, Mayur Pandya, Cynthia S Kubu, Paul J Ford, Andre G Machado
OBJECTIVE: The experience with deep brain stimulation (DBS) for pain is largely based on uncontrolled studies targeting the somatosensory pathways, with mixed results. We hypothesized that targeting limbic neural pathways would modulate the affective sphere of pain and alleviate suffering. METHODS: We conducted a prospective, double-blinded, randomized, placebo-controlled, crossover study of DBS targeting the ventral striatum/anterior limb of the internal capsule (VS/ALIC) in 10 patients with post-stroke pain syndrome...
April 5, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28376127/the-doc-screen-feasible-and-valid-screening-for-depression-obstructive-sleep-apnea-osa-and-cognitive-impairment-in-stroke-prevention-clinics
#9
Richard H Swartz, Megan L Cayley, Krista L Lanctôt, Brian J Murray, Ashley Cohen, Kevin E Thorpe, Michelle N Sicard, Karen Lien, Demetrios J Sahlas, Nathan Herrmann
BACKGROUND: Post-stroke Depression, Obstructive sleep apnea (OSA) and Cognitive impairment ("DOC") are associated with greater mortality, worse recovery and poorer quality of life. Best practice recommendations endorse routine screening for each condition; yet, all are under-assessed, diagnosed and treated. We seek to determine the feasibility and validity of an integrated tool ("DOC" screen) to identify stroke clinic patients at high-risk of depression, OSA, and cognitive impairment...
2017: PloS One
https://www.readbyqxmd.com/read/28359729/dl-3-n-butylphthalide-induced-neuroprotection-regenerative-repair-functional-recovery-and-psychological-benefits-following-traumatic-brain-injury-in-mice
#10
Yingying Zhao, Jin Hwan Lee, Dongdong Chen, Xiaohuan Gu, Asha Caslin, Jimei Li, Shan Ping Yu, Ling Wei
Previous investigations suggest that DL-3-n-butylphthalide (NBP) is a promising multifaceted drug for the treatment of stroke. It is not clear whether NBP can treat traumatic brain injury (TBI) and what could be the mechanisms of therapeutic benefits. To address these issues, TBI was induced by a controlled cortical impact in adult male mice. NBP (100 mg/kg) or saline was intraperitoneally administered within 5 min after TBI. One day after TBI, apoptotic events including caspase-3/9 activation, cytochrome c release from the mitochondria, and apoptosis-inducing factor (AIF) translocation into the nucleus in the pericontusion region were attenuated in NBP-treated mice compared to TBI-saline controls...
March 28, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28355353/influence-of-schooling-and-age-on-cognitive-performance-in-healthy-older-adults
#11
N V O Bento-Torres, J Bento-Torres, A M Tomás, V O Costa, P G R Corrêa, C N M Costa, N Y V Jardim, C W Picanço-Diniz
Few studies have examined the influence of a low level of schooling on age-related cognitive decline in countries with wide social and economic inequalities by using the Cambridge Automated Neuropsychological Test Battery (CANTAB). The aim of the present study was to assess the influence of schooling on age-related cognitive decline using unbiased cognitive tests. CANTAB allows cognitive assessment across cultures and education levels with reduced interference of the examiner during data acquisition. Using two-way ANOVA, we assessed the influences of age and education on test scores of old adults (61-84 years of age)...
March 23, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28350195/standard-sampling-microdialysis-and-spreading-depolarizations-in-patients-with-malignant-hemispheric-stroke
#12
Alexandra Pinczolits, Anna Zdunczyk, Nora F Dengler, Nils Hecht, Christina M Kowoll, Christian Dohmen, Rudolf Graf, Maren Kl Winkler, Sebastian Major, Jed A Hartings, Jens P Dreier, Peter Vajkoczy, Johannes Woitzik
Spreading depolarizations (SD) occur in high frequency in patients with malignant hemispheric stroke (MHS). Experimentally, SDs cause marked increases in glutamate and lactate, whereas glucose decreases. Here, we studied extracellular brain glutamate, glucose, lactate, pyruvate and the lactate/pyruvate ratio in relationship to SDs after MHS. We inserted two microdialysis probes in peri-infarct tissue at 5 and 15 mm to the infarct in close proximity to a subdural electrode strip. During 2356.6 monitoring hours, electrocorticography (ECoG) revealed 697 SDs in 16 of 18 patients...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28349855/reliability-of-the-neo-five-factor-inventory-short-form-for-assessing-personality-after-stroke
#13
Toni Dwan, Tamara Ownsworth, Caroline Donovan, Ada Ho Yan Lo
BACKGROUND: It is well recognized that an individual's personality characteristics influence their psychological adjustment after stroke. However, there is a lack of research on the reliability of personality inventories for stroke. This study primarily aimed to evaluate the reliability of the Neuroticism, Extroversion, Openness to Experience (NEO)-Five Factor Inventory (NEO-FFI) for assessing pre-morbid personality and personality changes after stroke. Further aims were to investigate changes in personality during the hospital-to-home transition period and examine associations between personality and mood...
March 28, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28330419/how-does-sex-affect-the-care-dependency-risk-one-year-after-stroke-a-study-based-on-claims-data-from-a-german-health-insurance-fund
#14
Susanne Schnitzer, Johannes Deutschbein, Christian H Nolte, Martin Kohler, Adelheid Kuhlmey, Liane Schenk
OBJECTIVES: The study explores the association between sex and care dependency risk one year after stroke. METHODS: The study uses claims data from a German statutory health insurance fund. Patients were included if they received a diagnosis of ischemic or hemorrhagic stroke between 1 January and 31 December 2007 and if they survived for one year after stroke and were not dependent on care before the event (n = 1851). Data were collected over a one-year period...
March 22, 2017: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/28320146/stroke-related-stigma-among-west-africans-patterns-and-predictors
#15
Fred Stephen Sarfo, Michelle Nichols, Suparna Qanungo, Abeba Teklehaimanot, Arti Singh, Nathaniel Mensah, Raelle Saulson, Mulugeta Gebregziabher, Uvere Ezinne, Mayowa Owolabi, Carolyn Jenkins, Bruce Ovbiagele
BACKGROUND: Disability-adjusted life-years lost after stroke in Low & Middle-Income Countries (LMICs) is almost seven times those lost in High-income countries. Although individuals living with chronic neurological and mental disorders are prone to stigma, there is a striking paucity of literature on stroke-related stigma particularly from LMICs. OBJECTIVE: To assess the prevalence, severity, determinants and psycho-social consequences of stigma among LMIC stroke survivors...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28318274/do-multiple-health-events-reduce-resilience-when-compared-with-single-events
#16
Ruth T Morin, Isaac R Galatzer-Levy, Fiona Maccallum, George A Bonanno
OBJECTIVE: The impact of multiple major life stressors is hypothesized to reduce the probability of resilience and increase rates of mortality. However, this hypothesis lacks strong empirical support because of the lack of prospective evidence. This study investigated whether experiencing multiple major health events diminishes rates of resilience and increases rates of mortality using a large population-based prospective cohort. METHOD: There were n = 1,395 individuals sampled from the Health and Retirement Study (HRS) and examined prospectively from 2 years before 4 years after either single or multiple health events (lung disease, heart disease, stroke, or cancer)...
March 20, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/28315868/cerebellar-fastigial-nucleus-electrical-stimulation-alleviates-depressive-like-behaviors-in-post-stroke-depression-rat-model-and-potential-mechanisms
#17
Lei Zhang, Mingkui Zhao, Ru-Bo Sui
OBJECTIVE: To identify the molecular mechanism of post-stroke depression (PSD), and observe the therapeutic effects of cerebellar fastigial nucleus electrical stimulation (FNS) on the behaviors and regional cerebral blood flow (rCBF) in a PSD rat model. METHODS: Healthy SD rats were randomly divided into four groups (sham, stroke, post-stroke depress and FNS group). Sham group (n = 6) underwent sham operation. The other three groups (n = 6*3) underwent MCAO. Rats were examined twice a week in open filed test...
March 16, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28314138/depression-and-post-traumatic-stress-disorder-in-individuals-with-hereditary-hemorrhagic-telangiectasia-a-cross-sectional-survey
#18
Shruti Chaturvedi, Marianne Clancy, Nicole Schaefer, Olalekan Oluwole, Keith R McCrae
INTRODUCTION: Hereditary hemorrhagic telangiectasia (HHT) is characterized by frequent severe bleeding, particularly epistaxis, and life-threatening complications including stroke, brain abscess and heart failure. The psychological impact of HHT is not known. We conducted this cross sectional study to determine the prevalence of depression and post-traumatic stress disorder (PTSD) related to HHT. METHODS: A survey tool comprising demographic and clinical information and two validated self-administered questionnaires, the PTSD checklist for DSM-5 (PCL-5) and Beck Depression Inventory-II (BDI-II), was distributed to individuals with HHT...
March 9, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28268517/structural-changes-of-cingulate-cortex-in-post-stroke-depression
#19
Chenfei Ye, Jun Wu, Xuhui Chen, Changle Zhang, Hengtong Li, Shuai Mao, Heather T Ma
Disruption of neural connections among regions regulating mood and cognition rather than cerebrovascular lesions may contribute to post-stroke depression (PSD). In this paper, we hypothesized that structural abnormalities in white matter structure like cingulate cortex induced by focal infarcts would play a role in mood regulation or depression after stroke onset. Various DTI coefficients including FA, RD and ADC with multiple signal distribution measurements were collected and statistically analyzed. The results identify significant differences in volume and multiple diffusion indices of DTI intensity distribution in cingulate cortex between PSD patients and the normal control...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28252843/chinese-family-caregivers-of-stroke-survivors-determinants-of-caregiving-burden-within-the-first-six-months
#20
Yanhong Han, Yilan Liu, Xuelin Zhang, Wilson Tam, Jing Mao, Violeta Lopez
AIMS AND OBJECTIVES: To describe the family caregivers' caregiving experience for stroke survivors and to identify the determinants of caregiving burden over six-months. BACKGROUND: Socio-cultural factors influence the caregiving experience in China. However, little is known about the dynamic changes occurring in Chinese caregivers' burden and its determinants. DESIGN: This is a prospective longitudinal study. METHODS: A total of 328 participants (164 stroke survivors and 164 family caregivers) from the neurological units of three hospitals in Shiyan were examined during a 6-month period at 1 to 2 days before discharge (T1), 3 weeks (T2), 3 months (T3), and 6 months (T4) post-discharge using the Short Portable Mental Status Questionnaire, Multidimensional Scale of Perceived Social Support, Caregiver Strain Index, and the Centre for Epidemiological Studies-Depression...
March 2, 2017: Journal of Clinical Nursing
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