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Induced hibernation

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https://www.readbyqxmd.com/read/27896650/neuroprotection-by-chlorpromazine-and-promethazine-in-severe-transient-and-permanent-ischemic-stroke
#1
Xiaokun Geng, Fengwu Li, James Yip, Changya Peng, Omar Elmadhoun, Jiamei Shen, Xunming Ji, Yuchuan Ding
Previous studies have demonstrated depressive or hibernation-like roles of phenothiazine neuroleptics [combined chlorpromazine and promethazine (C + P)] in brain activity. This ischemic stroke study aimed to establish neuroprotection by reducing oxidative stress and improving brain metabolism with post-ischemic C + P administration. Sprague-Dawley rats were subjected to transient (2 or 4 h) middle cerebral artery occlusion (MCAO) followed by 6 or 24 h reperfusion, or permanent (28 h) MCAO without reperfusion...
November 28, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27873260/label-free-quantitation-of-ribosomal-proteins-from-bacillus-subtilis-for-antibiotic-research
#2
Sina Schäkermann, Pascal Prochnow, Julia E Bandow
Current research is focusing on ribosome heterogeneity as a response to changing environmental conditions and stresses, such as antibiotic stress. Altered stoichiometry and composition of ribosomal proteins as well as association of additional protein factors are mechanisms for shaping the protein expression profile or hibernating ribosomes. Here, we present a method for the isolation of ribosomes to analyze antibiotic-induced changes in the composition of ribosomes in Bacillus subtilis or other bacteria. Ribosomes and associated proteins are isolated by ultracentrifugation and proteins are identified and quantified using label-free mass spectrometry...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27853604/hibernation-in-a-primate-does-sleep-occur
#3
Marina B Blanco, Kathrin H Dausmann, Sheena L Faherty, Peter Klopfer, Andrew D Krystal, Robert Schopler, Anne D Yoder
During hibernation, critical physiological processes are downregulated and thermogenically induced arousals are presumably needed periodically to fulfil those physiological demands. Among the processes incompatible with a hypome tabolic state is sleep. However, one hibernating primate, the dwarf lemur Cheirogaleus medius, experiences rapid eye movement (REM)-like states during hibernation, whenever passively reaching temperatures above 30°C, as occurs when it hibernates in poorly insulated tree hollows under tropical conditions...
August 2016: Royal Society Open Science
https://www.readbyqxmd.com/read/27845399/hypometabolism-during-daily-torpor-in-mice-is-dominated-by-reduction-in-the-sensitivity-of-the-thermoregulatory-system
#4
Genshiro A Sunagawa, Masayo Takahashi
Some mammals enter a hypometabolic state either daily torpor (minutes to hours in length) or hibernation (days to weeks), when reducing metabolism would benefit survival. Hibernators demonstrate deep torpor by reducing both the sensitivity (H) and the theoretical set-point temperature (TR) of the thermogenesis system, resulting in extreme hypothermia close to ambient temperature. However, these properties during daily torpor remain poorly understood due to the very short steady state of the hypometabolism and the large variation among species and individuals...
November 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27833457/itraq-based-proteomic-analysis-of-myofibrillar-contents-and-relevant-synthesis-and-proteolytic-proteins-in-soleus-muscle-of-hibernating-daurian-ground-squirrels-spermophilus-dauricus
#5
Hui Chang, Shan-Feng Jiang, Kai Dang, Hui-Ping Wang, Shen-Hui Xu, Yun-Fang Gao
BACKGROUND: Daurian ground squirrels (Spermophilus dauricus) deviate from significant increase of protein catabolism and loss of myofibrillar contents during long period of hibernation inactivity. METHODS: Here we use iTRAQ based quantitative analysis to examine proteomic changes in the soleus of squirrels in pre-hibernation, hibernation and post-hibernation states. The total proteolysis rate of soleus was measured by the release of the essential amino acid tyrosine from isolated muscles...
2016: Proteome Science
https://www.readbyqxmd.com/read/27805048/kisspeptin-and-rfrp-3-differentially-regulate-food-intake-and-metabolic-neuropeptides-in-the-female-desert-jerboa
#6
Rajae Talbi, Marie-Pierre Laran-Chich, Rabia Magoul, Seloua El Ouezzani, Valérie Simonneaux
Jerboas are wild rodents exhibiting exceptional adaptation to their desert environment. Under harsh autumn conditions, they shut down reproduction, increase body weight and hibernate, while during spring they become sexually active even under negative energy-balance. We recently reported that these rhythms are associated with synchronized changes in genes expressing reproductive (Kiss1, Rfrp) and metabolic (Npy and Pomc) peptides, raising the hypothesis of coordinated seasonal regulation of both functions. Here we analyzed whether kisspeptin and RFRP-3 regulate food-intake in parallel to their established reproductive functions...
November 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27792535/dietary-supplementation-with-n-3-polyunsaturated-fatty-acids-reduces-torpor-use-in-a-tropical-daily-heterotherm
#7
Pauline Vuarin, Pierre-Yves Henry, Martine Perret, Fabien Pifferi
Polyunsaturated fatty acids (PUFAs) are involved in a variety of physiological mechanisms, including heterothermy preparation and expression. However, the effects of the two major classes of PUFAs, n-6 and n-3, can differ substantially. While n-6 PUFAs enhance torpor expression, n-3 PUFAs reduce the ability to decrease body temperature. This negative impact of n-3 PUFAs has been revealed in temperate hibernators only. Yet because tropical heterotherms generally experience higher ambient temperature and exhibit higher minimum body temperature during heterothermy, they may not be affected as much by PUFAs as their temperate counterparts...
November 2016: Physiological and Biochemical Zoology: PBZ
https://www.readbyqxmd.com/read/27751318/instantaneous-unmasking-of-myocardial-hibernation-induced-by-microvascular-obstruction
#8
Ajit R Bhagwat, Sachin M Mukhedkar
No abstract text is available yet for this article.
September 2016: Indian Heart Journal
https://www.readbyqxmd.com/read/27620349/vitamin-b2-as-a-virulence-factor-in-pseudogymnoascus-destructans-skin-infection
#9
Miroslav Flieger, Hana Bandouchova, Jan Cerny, Milada Chudíčková, Miroslav Kolarik, Veronika Kovacova, Natália Martínková, Petr Novák, Ondřej Šebesta, Eva Stodůlková, Jiri Pikula
Pathogenic and non-pathogenic related microorganisms differ in secondary metabolite production. Here we show that riboflavin overproduction by a fungal pathogen and its hyperaccumulation in affected host tissue exacerbates a skin infection to necrosis. In white-nose syndrome (WNS) skin lesions caused by Pseudogymnoascus destructans, maximum riboflavin concentrations reached up to 815 μg ml(-1), indicating bioaccumulation and lack of excretion. We found that high riboflavin concentrations are cytotoxic under conditions specific for hibernation, affect bats' primary fibroblasts and induce cell detachment, loss of mitochondrial membrane potential, polymerization of cortical actin, and cell necrosis...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27614289/tissue-specific-response-of-carbohydrate-responsive-element-binding-protein-chrebp-to-mammalian-hibernation-in-13-lined-ground-squirrels
#10
Samantha M Logan, Kenneth B Storey
Mammalian hibernation is characterized by a general suppression of energy expensive processes and a switch to lipid oxidation as the primary fuel source. Glucose-responsive carbohydrate responsive element binding protein (ChREBP) has yet to be studied in hibernating organisms, which prepare for the cold winter months by feeding until they exhibit an obesity-like state that is accompanied by naturally-induced and completely reversible insulin resistance. Studying ChREBP expression and activity in the hibernating 13-lined ground squirrel is important to better understand the molecular mechanisms that regulate energy metabolism under cellular stress...
October 2016: Cryobiology
https://www.readbyqxmd.com/read/27593478/inhibition-of-skeletal-muscle-atrophy-during-torpor-in-ground-squirrels-occurs-through-downregulation-of-myog-and-inactivation-of-foxo4
#11
Yichi Zhang, Shannon N Tessier, Kenneth B Storey
Foxo4 and MyoG proteins regulate the transcription of numerous genes, including the E3 ubiquitin ligases MAFbx and MuRF1, which are activated in skeletal muscle under atrophy-inducing conditions. In the thirteen-lined ground squirrel, there is little muscle wasting that occurs during hibernation, a process characterized by bouts of torpor and arousal, despite virtual inactivity. Consequently, we were interested in studying the regulatory role of Foxo4 and MyoG on ubiquitin ligases throughout torpor-arousal cycles...
October 2016: Cryobiology
https://www.readbyqxmd.com/read/27568195/effects-of-seasonal-variation-on-oxidative-stress-physiology-in-natural-population-of-toad-bufo-melanostictus-clues-for-analysis-of-environmental-pollution
#12
Luna Samanta, Biswaranjan Paital
Natural population of Bufo melanostictus in response to environmental cues shows several physiologic changes such as reproductive activity, hibernation, aestivation and metabolic depression in different seasons. We investigated the effects of seasonal fluctuations on oxidative stress (OS) physiology biomarkers, such as endogenous (ELPx) and induced (ILPx) lipid peroxidation, front-line redox regulatory enzymes (superoxide dismutase: SOD and catalase) and two non-enzyme antioxidant metabolites (ascorbic acid and reduced glutathione) in liver, gonad and cerebral hemisphere of toads collected from the Bhubaneswar area of India, where temperature fluctuates considerably rising to the highest in summer (∼46 °C) and being lowest in winter (<10 °C)...
August 27, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27504499/first-detection-of-bat-white-nose-syndrome-in-western-north-america
#13
Jeffrey M Lorch, Jonathan M Palmer, Daniel L Lindner, Anne E Ballmann, Kyle G George, Kathryn Griffin, Susan Knowles, John R Huckabee, Katherine H Haman, Christopher D Anderson, Penny A Becker, Joseph B Buchanan, Jeffrey T Foster, David S Blehert
White-nose syndrome (WNS) is an emerging fungal disease of bats caused by Pseudogymnoascus destructans. Since it was first detected near Albany, NY, in 2006, the fungus has spread across eastern North America, killing unprecedented numbers of hibernating bats. The devastating impacts of WNS on Nearctic bat species are attributed to the likely introduction of P. destructans from Eurasia to naive host populations in eastern North America. Since 2006, the disease has spread in a gradual wavelike pattern consistent with introduction of the pathogen at a single location...
July 2016: MSphere
https://www.readbyqxmd.com/read/27414706/metal-organic-framework-coatings-as-cytoprotective-exoskeletons-for-living-cells
#14
Kang Liang, Joseph J Richardson, Jiwei Cui, Frank Caruso, Christian J Doonan, Paolo Falcaro
The biomimetic mineralization of metal-organic framework (MOF) material on living cells is reported. ZIF-8 can be crystallized on a living cell surface as an exoskeleton that offers physical protection while allowing transport of essential nutrients, thus maintaining cell viability. The MOF shell prevents cell division, leading to an artificially induced pseudo-hibernation state. Cellular functions can be fully restored upon MOF removal.
September 2016: Advanced Materials
https://www.readbyqxmd.com/read/27344571/regulation-of-gene-expression-by-nfat-transcription-factors-in-hibernating-ground-squirrels-is-dependent-on-the-cellular-environment
#15
Yichi Zhang, Kenneth B Storey
Calcineurin is a calmodulin-stimulated phosphatase that regulates the nuclear translocation of nuclear factor of activated T cell (NFAT) c1-4 through dephosphorylation. We believe that this mechanism plays various roles in the remodeling and maintenance of Ictidomys tridecemlineatus skeletal muscle. During hibernation, bouts of torpor and arousal take place, and squirrels do not lose muscle mass despite being inactive. Protein expression of Ca(2+) signaling proteins were studied using immunoblotting. A DNA-protein interaction ELISA technique was created to test the binding of NFATs in the nucleus to DNA probes containing the NFAT response element under environmental conditions reflective of those during hibernation...
September 2016: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/27333659/hibernation-hypothermia-and-a-possible-therapeutic-shifted-homeostasis-induced-by-central-activation-of-a1-adenosine-receptor-a1ar
#16
REVIEW
Domenico Tupone, Justin S Cetas, Shaun F Morrison
The positive outcome that hypothermia contributes to brain and cardiac protection following ischemia has stimulated research in the development of pharmacological approaches to induce a hypothermic/hypometabolic state. Pharmacological manipulation of central autonomic thermoregulatory circuits could represent a potential target for the induction of a hypothermic state. Here we present a brief description of the CNS thermoregulatory centers and how the manipulation of these circuits can be useful in the treatment of pathological conditions such as stroke or brain hemorrhage...
April 2016: Nihon Shinkei Seishin Yakurigaku Zasshi, Japanese Journal of Psychopharmacology
https://www.readbyqxmd.com/read/27322970/imaging-of-brown-adipose-tissue-state-of-the-art
#17
Srihari C Sampath, Srinath C Sampath, Miriam A Bredella, Aaron M Cypess, Martin Torriani
The rates of diabetes, obesity, and metabolic disease have reached epidemic proportions worldwide. In recent years there has been renewed interest in combating these diseases not only by modifying energy intake and lifestyle factors, but also by inducing endogenous energy expenditure. This approach has largely been stimulated by the recent recognition that brown adipose tissue (BAT)-long known to promote heat production and energy expenditure in infants and hibernating mammals-also exists in adult humans. This landmark finding relied on the use of clinical fluorine 18 fluorodeoxyglucose positron emission tomography/computed tomography, and imaging techniques continue to play a crucial and increasingly central role in understanding BAT physiology and function...
July 2016: Radiology
https://www.readbyqxmd.com/read/27256167/remarkable-preservation-of-ca-2-homeostasis-and-inhibition-of-apoptosis-contribute-to-anti-muscle-atrophy-effect-in-hibernating-daurian-ground-squirrels
#18
Weiwei Fu, Huanxin Hu, Kai Dang, Hui Chang, Bei Du, Xue Wu, Yunfang Gao
The underlying mechanisms that hibernators deviated from muscle atrophy during prolonged hibernating inactivity remain elusive. This study tested the hypothesis that the maintenance of intracellular Ca(2+) homeostasis and inhibition of apoptosis would be responsible for preventing muscle atrophy in hibernating Daurian ground squirrels. The results showed that intracellular Ca(2+) homeostasis was maintained in soleus and extensor digitorum longus (EDL) in hibernation and post-hibernation, while cytosolic Ca(2+) was overloaded in gastrocnemius (GAS) in hibernation with a recovery in post-hibernation...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27187119/proteomic-profiling-reveals-adaptive-responses-to-surgical-myocardial-ischemia-reperfusion-in-hibernating-arctic-ground-squirrels-compared-to-rats
#19
Quintin J Quinones, Zhiquan Zhang, Qing Ma, Michael P Smith, Erik Soderblom, M Arthur Moseley, James Bain, Christopher B Newgard, Michael J Muehlbauer, Matthew Hirschey, Kelly L Drew, Brian M Barnes, Mihai V Podgoreanu
BACKGROUND: Hibernation is an adaptation to extreme environments known to provide organ protection against ischemia-reperfusion (I/R) injury. An unbiased systems approach was utilized to investigate hibernation-induced changes that are characteristic of the hibernator cardioprotective phenotype, by comparing the myocardial proteome of winter hibernating arctic ground squirrels (AGS), summer active AGS, and rats subjected to I/R, and further correlating with targeted metabolic changes...
June 2016: Anesthesiology
https://www.readbyqxmd.com/read/27117803/pronounced-expression-of-the-lipolytic-inhibitor-g0-g1-switch-gene-2-g0s2-in-adipose-tissue-from-brown-bears-ursus-arctos-prior-to-hibernation
#20
Niels Jessen, Thomas S Nielsen, Mikkel H Vendelbo, Rikke Viggers, Ole-Gunnar Støen, Alina Evans, Ole Frøbert
Prior to hibernation, the brown bear (Ursus arctos) exhibits unparalleled weight gain. Unlike humans, weight gain in bears is associated with lower levels of circulating free fatty acids (FFA) and increased insulin sensitivity. Understanding how free-ranging brown bears suppress lipolysis when gaining weight may therefore provide novel insight toward the development of human therapies. Blood and subcutaneous adipose tissue were collected from immobilized free-ranging brown bears (fitted with GPS-collars) during hibernation in winter and from the same bears during the active period in summer in Dalarna, Sweden...
April 2016: Physiological Reports
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