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https://www.readbyqxmd.com/read/28637515/current-globalization-of-drug-interventional-clinical-trials-characteristics-and-associated-factors-2011-2013
#1
Sohyun Jeong, Minji Sohn, Jae Hyun Kim, Minoh Ko, Hee-Won Seo, Yun-Kyoung Song, Boyoon Choi, Nayoung Han, Han-Sung Na, Jong Gu Lee, In-Wha Kim, Jung Mi Oh, Euni Lee
BACKGROUND: Clinical trial globalization is a major trend for industry-sponsored clinical trials. There has been a shift in clinical trial sites towards emerging regions of Eastern Europe, Latin America, Asia, the Middle East, and Africa. Our study objectives were to evaluate the current characteristics of clinical trials and to find out the associated multiple factors which could explain clinical trial globalization and its implications for clinical trial globalization in 2011-2013. METHODS: The data elements of "phase," "recruitment status," "type of sponsor," "age groups," and "design of trial" from 30 countries were extracted from the ClinicalTrials...
June 21, 2017: Trials
https://www.readbyqxmd.com/read/28633699/migration-histories-of-multidrug-resistant-tuberculosis-patients-from-the-thailand-myanmar-border-2012-2014
#2
S S Thi, D M Parker, L L Swe, S Pukrittayakamee, C L Ling, K Amornpaisarnloet, M Vincenti-Delmas, F H Nosten
SETTING: Multidrug-resistant tuberculosis (MDR-TB) is a growing public health threat in South-East Asia. TB is typically a disease of poverty and can be spread by infectious humans who migrate from one region to another. DESIGN: We interviewed 20 MDR-TB patients on the Thailand-Myanmar border with regard to their migration histories. Migration origins and destinations were mapped. RESULTS: All but one participant had a history of migration, and maps of migration ranges revealed wide geographic dispersal...
July 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28633358/phylogeography-of-herbarium-specimens-of-asexually-propagated-paper-mulberry-broussonetia-papyrifera-l-l-h%C3%A3-r-ex-vent-moraceae-reveals-genetic-diversity-across-the-pacific
#3
Claudia Payacan, Ximena Moncada, Gloria Rojas, Andrew Clarke, Kuo-Fang Chung, Robin Allaby, Daniela Seelenfreund, Andrea Seelenfreund
Background and Aims: Paper mulberry or Broussonetia papyrifera (L.) L'Hér. ex Vent. (Moraceae) is a dioecious species native to continental South-east Asia and East Asia, including Taiwan, that was introduced to the Pacific by pre-historic voyagers and transported intentionally and propagated asexually across the full range of Austronesian expansion from Taiwan to East Polynesia. The aim of this study was to gain insight into the dispersal of paper mulberry into Oceania through the genetic analysis of herbaria samples which represent a more complete coverage of the historical geographical range of the species in the Pacific before later introductions and local extinctions occurred...
June 14, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28632789/movement-and-contact-patterns-of-long-distance-free-grazing-ducks-and-avian-influenza-persistence-in-vietnam
#4
Anne Meyer, Tung Xuan Dinh, Thu Van Nhu, Long Thanh Pham, Scott Newman, Thuy Thi Thanh Nguyen, Dirk Udo Pfeiffer, Timothée Vergne
Presence of ducks, and in particular of free-grazing ducks, has consistently been shown to be one of the most important risk factors for highly pathogenic avian influenza outbreaks which has compromised poultry production in South-East Asia since the early 2000s and continues to threaten public health, farmers' livelihood and food security. Although free-grazing duck production has been practised for decades in South-East Asia, there are few published studies describing this production system, which is suspected to play an important role in the maintenance of avian influenza viruses...
2017: PloS One
https://www.readbyqxmd.com/read/28629328/impact-of-systematic-capacity-building-on-cataract-surgical-service-development-in-25-hospitals
#5
Katherine Judson, Paul Courtright, Thulsiraj Ravilla, Rohit Khanna, Ken Bassett
BACKGROUND: This study measured the effectiveness and cost of a capacity building intervention in 25 eye hospitals in South Asia, East Africa and Latin America over 4 years. The intervention involved eye care non-governmental organizations or high-performing eye hospitals acting as "mentors" to underperforming eye hospitals- "mentees" in 10 countries. Intervention activities included systematic planning and support for training and key equipment purchases as well as hospital-specific mentoring which focused on strengthening leadership, increasing the volume and equity of community outreach, improving surgical quality and volume, strengthening organizational and financial management and streamlining operational processes...
June 19, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28628842/matching-genomic-molecular-aberrations-with-molecular-targeted-agents-are-biliary-tract-cancers-an-ideal-playground
#6
REVIEW
Loic Verlingue, Antoine Hollebecque, Valérie Boige, Michel Ducreux, David Malka, Charles Ferté
Biliary tract cancers (BTCs) are a heterogeneous group of tumours with geographical discrepancies in terms of incidence and risk factors. However, a convergent genomic and epigenetic mutational landscape emerges from the genome-wide screens of BTCs in South East Asia, Latin America and in the Western World. Specificities are observed for some alterations and anatomical subtypes: frequent fibroblast growth factor receptor 2 (FGFR2) and isocitrate dehydrogenase 1/2 (IDH1/2) alterations are specific to intrahepatic cholangiocarcinomas (ICCs), whereas frequent ERBB2 oncogene alterations are specific to extrahepatic cholangiocarcinomas (ECCs) and gallbladder carcinomas (GBCs)...
June 16, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28622342/national-survey-of-outcomes-and-practices-in-acute-respiratory-distress-syndrome-in-singapore
#7
Shahla Siddiqui, Zudin Puthucheary, Jason Phua, Benjamin Ho, Jonathan Tan, Siau Chuin, Noelle Louise Lim, Chai Rick Soh, Chian Min Loo, Addy Y H Tan, Amartya Mukhopadhyay, Faheem Ahmed Khan, Azman Johan, Aik Hau Tan, Graeme MacLaren, Juvel Taculod, Blesilda Ramos, Tun Aung Han, Matthew E Cove
INTRODUCTION: In the past 20 years, our understanding of acute respiratory distress syndrome (ARDS) management has improved, but the worldwide incidence and current outcomes are unclear. The reported incidence is highly variable, and no studies specifically characterise ARDS epidemiology in Asia. This observation study aims to determine the incidence, mortality and management practices of ARDS in a high income South East Asian country. METHODS: We conducted a prospective, population based observational study in 6 public hospitals...
2017: PloS One
https://www.readbyqxmd.com/read/28615043/-like-sugar-in-milk-reconstructing-the-genetic-history-of-the-parsi-population
#8
Gyaneshwer Chaubey, Qasim Ayub, Niraj Rai, Satya Prakash, Veena Mushrif-Tripathy, Massimo Mezzavilla, Ajai Kumar Pathak, Rakesh Tamang, Sadaf Firasat, Maere Reidla, Monika Karmin, Deepa Selvi Rani, Alla G Reddy, Jüri Parik, Ene Metspalu, Siiri Rootsi, Kurush Dalal, Shagufta Khaliq, Syed Qasim Mehdi, Lalji Singh, Mait Metspalu, Toomas Kivisild, Chris Tyler-Smith, Richard Villems, Kumarasamy Thangaraj
BACKGROUND: The Parsis are one of the smallest religious communities in the world. To understand the population structure and demographic history of this group in detail, we analyzed Indian and Pakistani Parsi populations using high-resolution genetic variation data on autosomal and uniparental loci (Y-chromosomal and mitochondrial DNA). Additionally, we also assayed mitochondrial DNA polymorphisms among ancient Parsi DNA samples excavated from Sanjan, in present day Gujarat, the place of their original settlement in India...
June 14, 2017: Genome Biology
https://www.readbyqxmd.com/read/28610789/comparative-study-of-genotypes-of-mycobacterium-tuberculosis-from-a-northern-indian-setting-with-strains-reported-from-other-parts-of-india-and-neighboring-countries
#9
Pragya Sharma, Kiran Katoch, Shilpi Chandra, Devendra Singh Chauhan, Vishnu Dutt Sharma, David Couvin, Nalin Rastogi, Vishwa Mohan Katoch
This study was carried out to characterize Mycobacterium tuberculosis population in Ghatampur, Kanpur, North India, by spoligotyping and Mycobacterial Interspersed Repetitive Units-Variable Number of Tandem Repeats (MIRU-VNTRs) typing. A total of 335 isolates were genotyped by spoligotyping and Central Asian (CAS) sub-lineage was the most prevalent, comprising 59.1% of all isolates. Other lineages were: East-African Indian (EAI) (19.10%), T (5.07%), Beijing (3.28%), Manu (2.98%), X (2.68%), S (0.89%), H3 (0...
July 2017: Tuberculosis
https://www.readbyqxmd.com/read/28607238/sri-lanka-takes-action-towards-a-target-of-zero-rabies-death-by-2020
#10
P A Lionel Harischandra, Amila Gunesekera, Navaratnasingam Janakan, Gyanendra Gongal, Bernadette Abela-Ridder
Rabies is a 100% vaccine-preventable and 100% fatal zoonotic, viral disease. It is usually spread to humans by saliva, through bites or scratches. Dogs are the source of the vast majority of human deaths from rabies. Political will and leadership have been the main drivers for success of the Sri Lankan effort to reduce the burden of disease attributable to rabies. Post-exposure prophylaxis, which is available in government health facilities, at no cost, to all bite patients, has been a main axis of the rabies-elimination strategy...
September 2016: WHO South-East Asia Journal of Public Health
https://www.readbyqxmd.com/read/28606821/analysis-of-synonymous-codon-usage-in-zika-virus
#11
Snawar Hussain, Sahibzada Tasleem Rasool
Zika virus is a zoonotic pathogen, which have made frequent incursion into the human population in Africa and South East Asia over the course of several decades but never reached to the pandemic proportions until the most recent outbreak. Viruses are solely dependent on host synthetic machinery for their replication cycle; therefore, replication and persistence in a host species of different genetic background requires certain degree of adaptation. These adaptations are necessary to avoid detection from host immune surveillance and maximize the utilization of available resources for efficient viral replication...
June 9, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28605887/perceived-environmental-pollution-and-its-impact-on-health-in-china-japan-and-south-korea
#12
Akiko Kamimura, Bianca Armenta, Maziar Nourian, Nushean Assasnik, Kimiya Nourian, Alla Chernenko
Objectives: Environmental pollution is a significant global issue. Both objective (scientifically measured) environmental pollution and perceived levels of pollution are important predictors of self-reported health. The purpose of this study was to compare the associations between perceived environmental pollution and health in China, Japan, and South Korea. Methods: Data were obtained from the East Asian Social Survey and the Cross-National Survey Data Sets: Health and Society in East Asia, 2010 (n=7938; China, n=3866; Japan, n=2496; South Korea, n=1576)...
2017: Journal of Preventive Medicine and Public Health, Yebang Ŭihakhoe Chi
https://www.readbyqxmd.com/read/28605854/central-tibetan-plateau-atmospheric-trace-metals-contamination-a-500-year-record-from-the-puruogangri-ice-core
#13
Emilie Beaudon, Paolo Gabrielli, M Roxana Sierra-Hernández, Anna Wegner, Lonnie G Thompson
A ~500-year section of ice core (1497-1992) from the Puruogangri ice cap has been analyzed at high resolution for 28 trace elements (TEs: Ag, Al, As, Ba, Bi, Cd, Co, Cr, Cs, Cu, Fe, Ga, Li, Mg, Mn, Na, Nb, Ni, Pb, Rb, Sb, Sn, Sr, Ti, Tl, U, V and Zn) to assess different atmospheric contributions to the ice and provide a temporal perspective on the diverse atmospheric influences over the central Tibetan Plateau (TP). At least two volcanic depositions have significantly impacted the central TP over the past 500years, possibly originating from the Billy Mitchell (1580, Papua New Guinea) and the Parker Peak (1641, Philippines) eruptions...
June 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28604290/politics-and-health-at-the-who-regional-office-for%C3%A2-south-east-asia-the-case-of-portuguese%C3%A2-india-%C3%A2-1949-61
#14
Monica Saavedra
This paper analyses how the 1950-61 conflict between Portugal and India over the territories that constituted Portuguese India (Goa, Daman and Diu) informed Portugal's relations with the World Health Organization's Regional Office for South East Asia (SEARO). The 'Goa question' determined the way international health policies were actually put into place locally and the meaning with which they were invested. This case study thus reveals the political production of SEARO as a dynamic space for disputes and negotiations between nation-states in decolonising Asia...
July 2017: Medical History
https://www.readbyqxmd.com/read/28603106/hematologic-adverse-effects-and-efficacy-monitoring-in-chronic-hepatitis-c-patients-treated-with-interferon-and-ribavirin-combination-therapy
#15
Ghazala Rafique, Allah Bukhsh, Asif Gul, Sonia Khiljee, Muhammad Ashraf, Muhammad Ovais Omer
180 million people are affected by chronic Hepatitis C Virus infection globally and more than 50 million in South East Asia. Combination of Interferon and Ribavirin is the current anti-HCV therapy in practice and is associated with certain hematologic adverse effects. In this concurrent observational study the incidence rate of major hematologic adverse effects and efficacy outcomes of Interferon and Ribavirin combination therapy was evaluated in 288 chronic hepatitis C patients at Lahore General Hospital. Levels of Hb, TLC, and Platelets counts were monitored for hematologic adverse effects monitoring, whereas, ALT, AST and bilirubin levels were monitored for efficacy...
January 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28599321/first-detection-of-foot-and-mouth-disease-virus-o-ind-2001d-in-vietnam
#16
Le T Vu, Ngo T Long, Barbara Brito, Carolina Stenfeldt, Nguyen T Phuong, Bui H Hoang, Steven J Pauszek, Ethan J Hartwig, George R Smoliga, Pham P Vu, Le T V Quang, Vo V Hung, Nguyen D Tho, Pham V Dong, Phan Q Minh, Miranda Bertram, Ian H Fish, Luis L Rodriguez, Do H Dung, Jonathan Arzt
In recent years, foot-and-mouth disease virus (FMDV) serotype O, topotype Middle East-South Asia (ME-SA), lineage Ind-2001d has spread from the Indian subcontinent to the Middle East, North Africa, and Southeast Asia. In the current report, we describe the first detection of this lineage in Vietnam in May, 2015 in Đắk Nông province. Three subsequent outbreaks caused by genetically related viruses occurred between May-October, 2015 after which the virus was not detected in clinical outbreaks for at least 15 subsequent months...
2017: PloS One
https://www.readbyqxmd.com/read/28597861/suicide-and-depression-in-the-world-health-organization-south-east-asia-region-a-systematic-review
#17
REVIEW
Helal Uddin Ahmed, Mohammad Didar Hossain, Afzal Aftab, Tanjir Rashid Soron, Mohammad Tariqul Alam, Md Waziul Alam Chowdhury, Aftab Uddin
Background Depression is the most common comorbid psychiatric disorder in people who die by suicide and 39% of global suicides occur in the World Health Organization (WHO) South-East Asia Region. The aim of this systematic review was to identify, for countries of this region, first the prevalence of depression among people who (i) die by, or (ii) attempt, suicide, and second, the proportion of people with depression who attempt or die by suicide. Methods PubMed, PsycINFO, EMBASE and Google Scholar were searched, together with five available national databases, for quantitative research papers published in English between 1956 and 4 September 2016 from the 11 countries of the WHO South-East Asia Region...
April 2017: WHO South-East Asia Journal of Public Health
https://www.readbyqxmd.com/read/28597860/co-occurring-depression-and-alcohol-use-disorders-in-south-east-asia-a-narrative-review
#18
REVIEW
Yatan Pal Singh Balhara, Prashant Gupta, Deeksha Elwadhi
Depression and alcohol-use disorders frequently co-occur and the presence of one augments the adverse consequences of the other. This article reviews and synthesizes the available literature on depression and alcohol-use disorders from the World Health Organization (WHO) South-East Asia Region, with respect to epidemiology, screening instruments, interventions and services, and policy. In common with other low- and middle-income settings, data from this region on co-occurring depression and alcohol-use disorders are scarce...
April 2017: WHO South-East Asia Journal of Public Health
https://www.readbyqxmd.com/read/28597856/challenges-and-opportunities-in-suicide-prevention-in-south-east-asia
#19
Lakshmi Vijayakumar
Suicide is a global public health problem, with over 800 000 people worldwide dying by suicide in 2012, according to the World Health Organization (WHO). The WHO South-East Asia Region is especially affected, with 39% of global suicides occurring in the 11 countries in this region. Women are a particularly vulnerable population, for a variety of social and cultural reasons. In India specifically, deaths by suicide for women peak in the age range 15-29 years. There is sufficient evidence to show that reduction of easy access to means of suicide is an effective prevention strategy...
April 2017: WHO South-East Asia Journal of Public Health
https://www.readbyqxmd.com/read/28597852/mental-health-policies-in-south-east-asia-and-the-public-health-role-of-screening-instruments-for-depression
#20
Pratap Sharan, Rajesh Sagar, Saurabh Kumar
The World Health Organization (WHO) South-East Asia Region, which contributes one quarter of the world's population, has a significant burden due to mental illnesses. Mental health has been a low priority in most countries of the region. Although most of these countries have national mental health policies, implementation at ground level remains a huge challenge. Many countries in the region lack mental health legislation that can safeguard the rights of people with mental illnesses, and governments have allocated low budgets for mental health services...
April 2017: WHO South-East Asia Journal of Public Health
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