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https://www.readbyqxmd.com/read/29784667/pattern-specific-transcriptomics-identifies-asgr2-as-a-predictor-of-hematogenous-recurrence-of-gastric-cancer
#1
Haruyoshi Tanaka, Mitsuro Kanda, Takashi Miwa, Chie Tanaka, Daisuke Kobayashi, Shinichi Umeda, Masahiro Shibata, Masaya Suenaga, Norifumi Hattori, Masamichi Hayashi, Naoki Iwata, Suguru Yamada, Goro Nakayama, Michitaka Fujiwara, Yasuhiro Kodera
Hematogenous recurrence is a challenging clinical finding that often leads to fatalities of patients with gastric cancer. Therefore, the identification of specific biomarkers and potential therapeutic target molecules for hematogenous recurrence is required to improve the outcomes of these patients. Here, transcriptome and bioinformatics analyses were conducted to uncover candidate molecules differentially expressed in patients with hematogenous recurrence of gastric cancer. One potential candidate identified was asialoglycoprotein receptor 2 (ASGR2) and small interfering RNA (siRNA) experiments were conducted to determine the effect of manipulating ASGR2 expression has on cell phenotypes...
May 21, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29777795/sirna-in-ovarian-cancer-delivery-strategies-and-targets-for-therapy
#2
REVIEW
Dirk van den Brand, Vicky Mertens, Leon F A G Massuger, Roland Brock
Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy, and the sixth leading cause of cancer related death in women overall. Despite improved surgical techniques and advances in chemotherapy, mortality hardly decreased over the last twenty years. The major problem is that (micro)metastases persevere in the abdominal cavity, causing incurable tumor recurrence. Therefore, there is an imminent need for new therapeutic strategies. Oligonucleotide (ON) based therapies such as RNA interference (RNAi) provide the possibility to specifically address disease-related pathways...
May 16, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29774943/-progress-in-prophylatic-hyperthermic-intraperitoneal-chemotherapy-for-advanced-gastric-carcinoma
#3
Xinhua Chen, Jun Luo, Hao Liu, Yuehong Chen, Yanfeng Hu, Tuanjie Li, Tian Lin, Yu Zhu, Mingli Zhao, Hao Chen, Guoxin Li, Jiang Yu
Advanced gastric cancer (AGC) has a high recurrence rate (especially peritoneal relapse) and a poor prognosis. Systematic chemotherapy or targeted therapy have not been able to significantly reduce the major cause of an unfavorable prognosis, namely the high peritoneal AGC recurrence rate post-surgery. Further studies concerning the application of hyperthermic intraperitoneal chemotherapy (HIPEC) post curative surgery for AGC patients, namely the prophylactic HIPEC (P-HIPEC), have involved a prophylactic approach to prevent peritoneal relapse following curative gastrectomy in high-risk patients...
May 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29771808/predicting-survival-after-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-for-appendix-adenocarcinoma
#4
Omer Aziz, Ihab Jaradat, Bipasha Chakrabarty, Chelliah R Selvasekar, Paul E Fulford, Mark P Saunders, Andrew G Renehan, Malcolm S Wilson, Sarah T O'Dwyer
BACKGROUND: Appendix adenocarcinomas are rare tumors with propensity for peritoneal metastasis. Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy is an established treatment with curative intent, but, to date, studies reporting survival have been heterogeneous with regard to their patient groups (including other tumor types), interventions (not all patients receiving intraperitoneal chemotherapy), and follow-up (varying surveillance protocols). OBJECTIVE: The aim of this study is to quantify the impact of this intervention on survival in a homogeneous group of patients with appendix adenocarcinoma receiving standardized treatment and follow-up, and to determine the impact of prognostic indicators on survival...
May 15, 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29770354/3d-co-culture-system-of-tumor-associated-macrophages-and-ovarian-cancer-cells
#5
Lingli Long, Mingzhu Yin, Wang Min
Ovarian cancer is fairly unique in that ovarian carcinoma cells can detach and spread directly through peritoneal cavity. It has been unclear, however, how detached cancer cells survive in the peritoneum and form spheroid structure. We have recently reported that there is a strong correlation between Tumor-associated macrophages (TAMs)-associated spheroid and clinical pathology of ovarian cancer, and that TAMs promote spheroid formation and tumor growth at early stages of transcoelomic metastasis in orthotopic mouse models...
April 20, 2018: Bio-protocol
https://www.readbyqxmd.com/read/29767252/colony-stimulating-factor-1-and-colony-stimulating-factor-1-receptor-co-expression-is-associated-with-disease-progression-in-gastric-cancer
#6
Yoshinaga Okugawa, Yuji Toiyama, Takashi Ichikawa, Mikio Kawamura, Hiromi Yasuda, Hiroyuki Fujikawa, Susumu Saigusa, Masaki Ohi, Toshimitsu Araki, Koji Tanaka, Yasuhiro Inoue, Motoyoshi Tanaka, Chikao Miki, Masato Kusunoki
Colony‑stimulating‑factor‑1 (CSF‑1) is a hematopoietic growth factor that exerts its effects through the c‑fms/CSF‑1 receptor (CSF‑1R). The CSF‑1/CSF‑1R axis is thought to be involved in the development of several types of cancer. This study aimed to clarify the clinical and biological significance of the CSF‑1/CSF‑1R axis in gastric cancer (GC). For this purpose, we evaluated CSF‑1 and CSF‑1R expression in GC tissues from 148 patients by RT‑qPCR and immunohistochemistry. The biological roles of the CSF‑1/CSF‑1R axis were investigated by measuring the cell proliferation and migration, and anoikis resistance in a human GC cell line following treatment with recombinant human CSF‑1 and/or CSF‑1R inhibitor...
May 16, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29766314/metastatic-colon-cancer-derived-from-a-diverticulum-incidentally-found-at-herniorrhaphy-a-case-report
#7
Jiro Kimura, Alan Kawarai Lefor, Shota Fukai, Kentaro Yoshikawa, Shingo Sasamatsu, Takashi Sakamoto, Ken Mizokami, Masaki Kanzaki, Tadao Kubota, Akira Saito, Hiroshi Izumi, Kunpei Honjo, Kunihiko Nagakari, Masaki Fukunaga
BACKGROUND: There are few reports of metastases from colon cancer to an inguinal hernia sac, and few reports of colon cancer originating in diverticula. We report a patient with carcinoma of the sigmoid colon arising in two diverticula, who presented with peritoneal seeding to an inguinal hernia sac, and a review of the literature. CASE PRESENTATION: A 55-year-old male underwent open herniorrhaphy for a left inguinal hernia. At operation, a nodule in the inguinal hernia sac was resected and histologic examination revealed adenocarcinoma, which was suspected to be a metastasis from a distant primary lesion...
May 15, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29754071/aging-increases-susceptibility-to-ovarian-cancer-metastasis-in-murine-allograft-models-and-alters-immune-composition-of-peritoneal-adipose-tissue
#8
Elizabeth A Loughran, Annemarie K Leonard, Tyvette S Hilliard, Ryan C Phan, Madeleine G Yemc, Elizabeth Harper, Emma Sheedy, Yuliya Klymenko, Marwa Asem, Yueying Liu, Jing Yang, Jeff Johnson, Laura Tarwater, Zonggao Shi, Matthew Leevy, Matthew J Ravosa, M Sharon Stack
Ovarian cancer, the most deadly gynecological malignancy in U.S. women, metastasizes uniquely, spreading through the peritoneal cavity and often generating widespread metastatic sites before diagnosis. The vast majority of ovarian cancer cases occur in women over 40 and the median age at diagnosis is 63. Additionally, elderly women receive poorer prognoses when diagnosed with ovarian cancer. Despite age being a significant risk factor for the development of this cancer, there are little published data which address the impact of aging on ovarian cancer metastasis...
May 10, 2018: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29753612/concentrations-of-cisplatin-and-doxorubicin-in-ascites-and-peritoneal-tumor-nodules-before-and-after-pressurized-intraperitoneal-aerosol-chemotherapy-pipac-in-patients-with-peritoneal-metastasis
#9
Clemens B Tempfer, Ziad Hilal, Askin Dogan, Miriam Petersen, Günther A Rezniczek
INTRODUCTION: Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a new means of delivering chemotherapy into the abdomen of patients with peritoneal carcinomatosis (PC). The amount of drug uptake in ascites and peritoneum after PIPAC is unknown. METHODS: Retrospective cohort study of women with PC from gynecological tumors comparing the concentrations of cisplatin and doxorubicin in ascites and peritoneum before and after PIPAC. Concentrations were measured using gas chromatography...
May 4, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29752717/tumor-progression-and-metastatic-dissemination-in-ovarian-cancer-after-dose-dense-or-conventional-paclitaxel-and-cisplatin-plus-bevacizumab
#10
Francesca Bizzaro, Francesca Falcetta, Elisa D'Agostini, Alessandra Decio, Lucia Minoli, Eugenio Erba, Fedro Alessandro Peccatori, Eugenio Scanziani, Nicoletta Colombo, Massimo Zucchetti, MariaRosa Bani, Paolo Ubezio, Raffaella Giavazzi
The efficacy of therapeutic regimens incorporating weekly or every-3-weeks paclitaxel (PTX) for ovarian cancer is debated. We investigated the addition of bevacizumab in regimens of chemotherapy with different PTX doses and schedules in preclinical models. Treatments were cisplatin (DDP) with weekly PTX (conventional), or dose-dense-equi (every other day to the conventional cumulative dose), or dose-dense-high (total dose 1.5 times higher), with or without bevacizumab. Treatment efficacy was evaluated analyzing tumor growth in different time-windows in two patient-derived ovarian cancer xenografts with different sensitivity to cisplatin...
May 11, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29749455/anti%C3%A2-metastatic-effects-of-aidi-on-human-esophageal-squamous-cell-carcinoma-by-inhibiting-epithelial%C3%A2-mesenchymal-transition-and-angiogenesis
#11
Qingtong Shi, Yali Diao, Feng Jin, Zhiyan Ding
Aidi injection, a proprietary Chinese medicine, has been widely used for the treatment of cancer. However, its effects and potential mechanism in esophageal squamous cell carcinoma (ESCC) have not yet been characterized. The aim of the present study was to identify the mechanism underlying the anti‑metastatic effects of treatment with Aidi. To test the effects and mechanism, EC9706 and KYSE70 cells were selected for in vitro experiments. In vivo, the anti‑metastatic effects of Aidi injection on a nude mouse peritoneal metastasis model were examined, and the mechanisms were assessed with immunohistochemical staining...
May 4, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29749431/expression-of-annexin-ii-and-stromal-tenascin-c-promotes-epithelial-to-mesenchymal-transition-and-correlates-with-distant-metastasis-in-pancreatic-cancer
#12
Naoko Yoneura, Shigetsugu Takano, Hideyuki Yoshitomi, Yasuyuki Nakata, Reiri Shimazaki, Shingo Kagawa, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Masaru Miyazaki, Masayuki Ohtsuka
The interaction between cancer cells and stromal components contributes to cancer invasion and metastasis in pancreatic ductal adenocarcinoma (PDAC). The present study investigated the role of the correlation between annexin II (ANX2) and stromal tenascin C (TNC) with the progression of PDAC. The functions of the expression ANX2 and TNC were assessed in in vitro experiments using mouse and human PDAC cells, and the clinical effect was analyzed using immunohistochemistry with surgically resected PDAC tissues...
May 2, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29746229/phase-iii-trial-comparing-intraperitoneal-and-intravenous-paclitaxel-plus-s-1-versus-cisplatin-plus-s-1-in-patients-with-gastric-cancer-with-peritoneal-metastasis-phoenix-gc-trial
#13
Hironori Ishigami, Yoshiyuki Fujiwara, Ryoji Fukushima, Atsushi Nashimoto, Hiroshi Yabusaki, Motohiro Imano, Haruhiko Imamoto, Yasuhiro Kodera, Yoshikazu Uenosono, Kenji Amagai, Shigenori Kadowaki, Hiroto Miwa, Hironori Yamaguchi, Takuhiro Yamaguchi, Tempei Miyaji, Joji Kitayama
Purpose Intraperitoneal paclitaxel plus systemic chemotherapy demonstrated promising clinical effects in patients with gastric cancer with peritoneal metastasis. We aimed to verify its superiority over standard systemic chemotherapy in overall survival. Patients and Methods This randomized phase III trial enrolled patients with gastric cancer with peritoneal metastasis who had received no or short-term (< 2 months) chemotherapy. Patients were randomly assigned at a two-to-one ratio to receive intraperitoneal and intravenous paclitaxel plus S-1 (IP; intraperitoneal paclitaxel 20 mg/m2 and intravenous paclitaxel 50 mg/m2 on days 1 and 8 plus S-1 80 mg/m2 per day on days 1 to 14 for a 3-week cycle) or S-1 plus cisplatin (SP; S-1 80 mg/m2 per day on days 1 to 21 plus cisplatin 60 mg/m2 on day 8 for a 5-week cycle), stratified by center, previous chemotherapy, and extent of peritoneal metastasis...
May 10, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29745097/quality-of-life-after-cytoreductive-surgery-and-hipec-a-single-centre-prospective-study
#14
Nikolaos Kopanakis, Eleftherios-Orestis Argyriou, Dimitra Vassiliadou, Christina Sidera, Maria Chionis, John Kyriazanos, Elias Efstathiou, John Spiliotis
PURPOSE: Cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) has become a crucial method in the management of peritoneal metastasis. This study evaluated the Quality of Life (QoL) post CRS plus HIPEC. METHODS: 80/95 patients underwent CRS plus HIPEC at the Metaxa Cancer Hospital, Piraeus, Greece from 06/2011 to 06/2015 and completed the colorectal version of the Functional Assessment of Cancer Therapy questionnaire (FACTC, version 4) at 1 week pre-operatively and at 1, 3, 6, 12, 18, 24 months post-operatively...
March 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29743567/mir-338-3p-functions-as-a-tumor-suppressor-in-gastric-cancer-by-targeting-ptp1b
#15
Feng Sun, Mengchao Yu, Jing Yu, Zhijian Liu, Xinyan Zhou, Yanqing Liu, Xiaolong Ge, Haidong Gao, Mei Li, Xiaohong Jiang, Song Liu, Xi Chen, Wenxian Guan
Gastric cancer (GC) is one of the most common malignant tumors and peritoneal metastasis is the primary cause for advanced GC's mortality. Protein-tyrosine phosphatase 1B (PTP1B) functions as an oncogene and involves in carcinogenesis and cancer dissemination. However, the function and regulation of PTP1B in GC remain poorly understood. In this study, we found that PTP1B was upregulated in GC tissues and overexpression of PTP1B in vitro promoted cell migration and prevented apoptosis. Then, we predicted that PTP1B was a target of miR-338-3p and we revealed an inverse correlation between miR-338-3p levels and PTP1B protein levels in GC tissues...
May 9, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29741294/synaptotagmin-xiii-expression-and-peritoneal-metastasis-in-gastric-cancer
#16
M Kanda, D Shimizu, H Tanaka, C Tanaka, D Kobayashi, M Hayashi, H Takami, Y Niwa, S Yamada, T Fujii, H Sugimoto, Y Kodera
BACKGROUND: Peritoneal metastasis is a frequent cause of death in patients with gastric cancer. The aim of this study was to identify molecules responsible for mediating peritoneal metastasis of gastric cancer. METHODS: Transcriptome and bioinformatics analyses were conducted to identify molecules associated with peritoneal metastasis. The therapeutic effects of intraperitoneally administered small interfering (si) RNA were evaluated using mouse xenograft models...
May 9, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29739756/alternatively-activated-macrophages-upregulate-mesothelial-expression-of-p-selectin-to-enhance-adhesion-of-ovarian-cancer-cells
#17
Molly J Carroll, Kaitlin C Fogg, Harin A Patel, Harris B Krause, Anne-Sophie Mancha, Manish S Patankar, Paul S Weisman, Lisa Barroilhet, Pamela K Kreeger
Peritoneal metastasis of high-grade serous ovarian cancer (HGSOC) occurs when tumor cells suspended in ascites adhere to mesothelial cells. Despite the strong relationship between metastatic burden and prognosis in HGSOC, there are currently no therapies specifically targeting the metastatic process. We utilized a co-culture model and multivariate analysis to examine how interactions between tumor cells, mesothelial cells, and alternatively-activated macrophages (AAMs) influence the adhesion of tumor cells to mesothelial cells...
May 8, 2018: Cancer Research
https://www.readbyqxmd.com/read/29738182/-epididymal-liposarcoma-with-metastases-to-the-retroperitoneal-space-and-peritoneal-cavity-a-case-report-and-literature-review
#18
Jun-Long Li, Jie Fan
Objective: To report a rare case of epididymal liposarcoma with multiple metastases to the retroperitoneal space and peritoneal cavity for the purpose of improving the diagnosis and treatment of the disease. METHODS: We retrospectively analyzed the clinical data about a case of epididymal liposarcoma with multiple metastases to the retroperitoneal space and peritoneal cavity, reviewed relevant literature at home and abroad, and investigated the presentation, diagnosis and treatment of the disease...
December 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29733517/a-novel-dual-marker-expression-panel-for-easy-and-accurate-risk-stratification-of-patients-with-gastric-cancer
#19
Mitsuro Kanda, Kenta Murotani, Haruyoshi Tanaka, Takashi Miwa, Shinichi Umeda, Chie Tanaka, Daisuke Kobayashi, Masamichi Hayashi, Norifumi Hattori, Masaya Suenaga, Suguru Yamada, Goro Nakayama, Michitaka Fujiwara, Yasuhiro Kodera
Development of specific biomarkers is necessary for individualized management of patients with gastric cancer. The aim of this study was to design a simple expression panel comprising novel molecular markers for precise risk stratification. Patients (n = 200) who underwent gastrectomy for gastric cancer were randomly assigned into learning and validation sets. Tissue mRNA expression levels of 15 candidate molecular markers were determined using quantitative PCR analysis. A dual-marker expression panel was created according to concordance index (C-index) values of overall survival for all 105 combinations of two markers in the learning set...
May 7, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29722542/repolarization-of-tumor-associated-macrophages-in-a-genetically-engineered-non-small-cell-lung-cancer-model-by-intraperitoneal-administration-of-hyaluronic-acid-based-nanoparticles-encapsulating-microrna-125b
#20
Neha N Parayath, Avani Parikh, Mansoor M Amiji
Tumor-associated macrophages (TAMs) acquire a pro-tumor (M2) phenotype, which promotes tumor growth, angiogenesis, and metastasis. Certain microRNAs (miRs), such as miR-125b, can reprogram TAMs into an anti-tumor/pro-inflammatory (M1) phenotype. Using CD44 targeting hyaluronic acid-poly(ethyleneimine) (HA-PEI)-based nanoparticles encapsulating miR-125b, we have herein shown macrophage-specific delivery and transfection upon intraperitoneal (i.p.) administration. We have exploited the inherent ability of peritoneal macrophages to migrate towards the inflammation/injury and demonstrated that following intraperitoneal administration of HA-PEI nanoparticles, there is an accumulation of HA-PEI nanoparticles in the macrophage-ablated lung tissues of both naïve and KRAS/p53 double mutant genetically engineered (KP-GEM) non-small cell lung cancer (NSCLC) mouse model...
May 3, 2018: Nano Letters
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