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https://www.readbyqxmd.com/read/29330531/low-density-neutrophils-ldn-in-postoperative-abdominal-cavity-assist-the-peritoneal-recurrence-through-the-production-of-neutrophil-extracellular-traps-nets
#1
Rihito Kanamaru, Hideyuki Ohzawa, Hideyo Miyato, Shiro Matsumoto, Hidenori Haruta, Kentaro Kurashina, Shin Saito, Yoshinori Hosoya, Hironori Yamaguchi, Hiroharu Yamashita, Yasuyuki Seto, Alan Kawarai Lefor, Naohiro Sata, Joji Kitayama
Many types of immune cells appear in peritoneal cavity after abdominal surgery. In patients who underwent laparotomy due to gastric cancer, peritoneal lavages were obtained before and after surgical procedure. Cells were recovered from intermediate layer after Ficoll-Hypaque centrifugation and analyzed for phenotypes and functions, especially focused on low density neutrophils (LDN). The number of CD66b (+) LDN with mature phenotype was markedly elevated in postoperative as compared with preoperative lavages...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29330272/spontaneous-splenic-rupture-as-a-rare-complication-of-g-csf-injection
#2
Soraya Benguerfi, Fanny Thepault, Hervé Lena, Charles Ricordel
Splenic rupture is an infrequent and underdiagnosed side effect of granylocyte colony-stimulating factor (G-CSF). We report the case of a 54-year-old woman with brain and bone metastasis in a lung adenocarcinoma who was admitted for faintness 28 days after a G-CSF injection. Abdominal CT scan confirmed the diagnosis of splenic rupture. A conservative treatment was chosen using a peritoneal cleansing during laparoscopic surgery. Clinicians should be aware of this rare toxicity as it could be severe, but easily reversible using appropriate surgical treatment...
January 12, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29328371/cd133-expression-predicts-post-operative-recurrence-in-patients-with-colon-cancer-with-peritoneal-metastasis
#3
Hiroshi Nagata, Soichiro Ishihara, Junko Kishikawa, Hirofumi Sonoda, Koji Murono, Shigenobu Emoto, Manabu Kaneko, Kazuhito Sasaki, Kensuke Otani, Takeshi Nishikawa, Toshiaki Tanaka, Tomomichi Kiyomatsu, Keisuke Hata, Kazushige Kawai, Hiroaki Nozawa
Despite extensive research on cancer stem cells in colorectal cancer, the impact of stem cell markers on patient survival remains unclear, particularly in those with distant metastasis. In this study, we focused on colon cancer with peritoneal metastasis and investigated the association between the expression of CD133, aldehyde dehydrogenase-1 (ALDH1) and leucine-rich repeating G-protein coupled receptor-5 (Lgr5), and disease prognosis. Putative stem cell marker expression was immunohistochemically evaluated in samples from 142 primary tumours and 75 peritoneal nodules...
January 8, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29327265/successful-diagnosis-of-an-occult-fallopian-tube-carcinoma-detected-from-the-diaphragm-metastasis
#4
Takahide Toyoda, Hidemi Suzuki, Takahiro Nakajima, Takekazu Iwata, Ayumu Matsuoka, Kyoko Nishikimi, Yoko Yonemori, Makio Shozu, Yukio Nakatani, Ichiro Yoshino
We herein reported a rare case of an occult fallopian tube carcinoma first detected from the diaphragm metastasis. An 83-year-old woman who had a 30-mm tumor on the right diaphragm underwent radical resection. Pathologically, the tumor was diagnosed as a high-grade serous adenocarcinoma, suggesting metastasis from the pelvic visceral carcinoma. Although the primary site could not be detected by imaging examinations, laparoscopy revealed multiple peritoneal disseminations; therefore, total hysterectomy was performed...
January 11, 2018: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29324540/metastatic-involvement-of-lesser-sac-in-advanced-epithelial-ovarian-cancer
#5
Asima Mukhopadhyay, Nicolò Bizzarri, Melissa Bradbury, Subir Sinha, Jaydip Bhaumik, C William Helm
OBJECTIVES: In advanced epithelial ovarian cancer (AOC), lesser sac (LS) metastasis particularly to the supragastric LS (SGLS) may be overlooked, resulting in unrecognized residual disease. We aimed to identify the frequency, distribution, and predictors of LS metastasis using laparoscopic evaluation at laparotomy and perioperative surgical complications associated with evaluation and resection/ablation. METHODS: Prospective observational study in consecutive patients with AOC undergoing laparotomy for primary or interval cytoreductive surgery in 2 centers between November 2013 and December 2016...
January 10, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29324533/multicenter-clinicopathological-study-of-high-grade-serous-carcinoma-presenting-as-primary-peritoneal-carcinoma
#6
Shinichi Komiyama, Yoshihiro Nishijima, Haruhiro Kondo, Hiroyuki Nomura, Satoshi Yamaguchi, Masayuki Futagami, Hiroharu Arai, Yoshihito Yokoyama, Nao Suzuki, Mikio Mikami, Kaneyuki Kubushiro, Daisuke Aoki, Yasuhiro Udagawa, Ryuichiro Nishimura
OBJECTIVE: We conducted a multicenter clinicopathological study to characterize patients with high-grade serous carcinoma presenting as primary peritoneal carcinoma (clinical PPC). METHODS: At 9 sites in Japan, patients with clinical PPC diagnosed according to Gynecologic Oncology Group criteria were enrolled retrospectively. The Gynecologic Oncology Group criteria allow for minor ovarian involvement by high-grade serous carcinoma. There was no systematic detailed histopathological review of the fallopian tubes to determine whether they were involved by serous carcinoma...
January 10, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29321007/staging-laparoscopy-for-locally-advanced-gastric-cancer-in-chinese-patients-a-multicenter-prospective-registry-study
#7
Ziyu Li, Zhemin Li, Lianhai Zhang, Qian Liu, Zhenjun Wang, Zhongtao Zhang, Gang Xiao, Wei Fu, Xin Wang, Yingjiang Ye, Jianchun Yu, Fei Li, Lin Chen, Shibin Wang, Jiafu Ji
BACKGROUND: Staging laparoscopy(SL) is a recommended technique for the staging of Gastric Cancer(GC) and provides the indication for a radical surgery. Considering the medical practice in China, the standardized and regular usage of SL is yet to be spread. However, existing guidelines vary and make an ambiguity of indication for SL. Besides, the specific indication for Chinese patients remains a niche. This study aims to the essential, missing information of Chinese patients and tries to normalize the indication of LS in medical practice in China...
January 10, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29312573/improvement-of-anti-cancer-drug-efficacy-via-thermosensitive-hydrogel-in-peritoneal-carcinomatosis-in-gastric-cancer
#8
Tae-Su Han, Keun Hur, Boram Choi, Ji-Yeon Lee, Sun-Ju Byeon, Jimin Min, Jieun Yu, Jung-Kyo Cho, Jimin Hong, Hyuk-Joon Lee, Seong-Ho Kong, Woo-Ho Kim, Kazuyoshi Yanagihara, Soo-Chang Song, Han-Kwang Yang
Peritoneal carcinomatosis (PC) of gastric origin has a poor prognosis with short survival due to lack of effective therapeutic modalities. Here, we evaluated the therapeutic efficacy of an injectable thermosensitive poly (organophosphazene) (PPZ) hydrogel with docetaxel (DTX-gel) to develop an effective therapeutic agent for patient with PC. Three days after inoculation of highly metastatic 44As3Luc cells into peritoneal cavity, the mice were intravenously or intraperitoneally administered with docetaxel alone (DTX-sol IV or IP), and intraperitoneally injected with DTX-gel...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29306747/heterocellular-3d-scaffolds-as-biomimetic-to-recapitulate-the-tumor-microenvironment-of-peritoneal-metastases-in%C3%A2-vitro-and-in%C3%A2-vivo
#9
Emiel De Jaeghere, Elly De Vlieghere, Jasper Van Hoorick, Sandra Van Vlierberghe, Glenn Wagemans, Leen Pieters, Elodie Melsens, Marleen Praet, Jo Van Dorpe, Matthieu N Boone, Rouba Ghobeira, Nathalie De Geyter, Marc Bracke, Christian Vanhove, Sara Neyt, Geert Berx, Bruno G De Geest, Peter Dubruel, Heidi Declercq, Wim Ceelen, Olivier De Wever
Peritoneal metastasis is a major cause of death and preclinical models are urgently needed to enhance therapeutic progress. This study reports on a hybrid hydrogel-polylactic acid (PLA) scaffold that mimics the architecture of peritoneal metastases at the qualitative, quantitative and spatial level. Porous PLA scaffolds with controllable pore size, geometry and surface properties are functionalized by type I collagen hydrogel. Co-seeding of cancer-associated fibroblasts (CAF) increases cancer cell adhesion, recovery and exponential growth by in situ heterocellular spheroid formation...
December 23, 2017: Biomaterials
https://www.readbyqxmd.com/read/29303207/elevated-cathepsin-k-potentiates-metastasis-of-epithelial-ovarian-cancer
#10
Xiujie Fan, Chongjuan Wang, Xianhui Song, Huaqing Liu, Xue Li, Yuanfang Zhang
Cathepsin K, or CTSK, has been found to be involved in the peritoneal metastasis of ovarian carcinoma. However, the expression and clinicopathological significance of CTSK remains unknown in epithelial ovarian cancer (EOC). The aim of the present study was to investigate the expression of CTSK and its clinicopathological significance in EOC. CTSK expression was evaluated using immunohistochemistry in EOC tissue microarray. The expression of CTSK in EOC was displayed to be markedly higher than that of adjacent normal control...
January 5, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/29299372/heated-intraperitoneal-chemotherapy-and-gastrectomy-for-gastric-cancer-in-the-u-s-the-time-is-now
#11
REVIEW
Zachary J Brown, Jonathan M Hernandez, R Taylor Ripley, Jeremy L Davis
Peritoneal metastasis is a common final pathway in patients with gastric adenocarcinoma. Microscopic evidence of early peritoneal dissemination of gastric cancer is present in a substantial proportion of patients presumed to have localized disease. Prognosis is poor even for patients with microscopic and low-volume peritoneal carcinomatosis highlighting the need for a more effective treatment strategy. Treatment of peritoneal carcinomatosis with intraperitoneal chemotherapy has been evaluated in gastric cancer and is associated with improved survival in selected patients...
December 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29299357/the-correlations-between-serum-amphiregulin-and-other-clinicopathological-factors-in-colorectal-cancer
#12
Chawalit Chayangsu, Siriporn Khunsri, Virote Sriuranpong, Suebpong Tanasanvimon
Background: Amphiregulin (AREG) is one of the epidermal growth factor receptor (EGFR) ligands and plays the important roles in tumor progression and metastasis. Upregulation of AREG in colorectal cancer (CRC) tissues has been shown to correlate with depth of tumor invasion, nerve invasion and liver metastasis. We sought to investigate a correlation of serum AREG in CRC with clinicopathological parameters. Methods: Patients with CRC receiving treatment at King Chulalongkorn Memorial Hospital during August 2013 to March 2014 were enrolled...
December 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29290969/low-plasma-levels-of-mir-101-are-associated-with-tumor-progression-in-gastric-cancer
#13
Taisuke Imamura, Shuhei Komatsu, Daisuke Ichikawa, Mahito Miyamae, Wataru Okajima, Takuma Ohashi, Jun Kiuchi, Keiji Nishibeppu, Toshiyuki Kosuga, Hirotaka Konishi, Atsushi Shiozaki, Kazuma Okamoto, Hitoshi Fujiwara, Eigo Otsuji
Background: Several studies have identified the decreased expression of the tumor suppressor miR-101 in various cancers. In this study, we tested miR-101 as a potential therapeutic target and novel plasma biomarker for gastric cancer (GC). Results: The miR-101 expression level was significantly lower in GC tissues (P = 0.0038) and GC cell lines (P = 0.0238) than in normal gastric mucosa. Both exosomal and plasma miR-101 were significantly downregulated in GC patients compared with healthy volunteers (P = 0...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29288515/a-third-generation-oncolytic-herpes-simplex-virus-inhibits-the-growth-of-liver-tumors-in-mice
#14
Richi Nakatake, Masaki Kaibori, Yusuke Nakamura, Yoshito Tanaka, Hideyuki Matushima, Tadayoshi Okumura, Takashi Murakami, Yasushi Ino, Tomoki Todo, Masanori Kon
Multimodality therapies are used to manage patients with hepatocellular carcinoma (HCC), although advanced HCC is incurable. Oncolytic virus therapy is probably the next major breakthrough in cancer treatment. The third-generation oncolytic herpes simplex virus type 1 (HSV-1) T-01 kills tumor cells without damaging the surrounding normal tissues. Here we investigated the antitumor effects of T-01 on HCC and the host's immune response to HCC cells. The cytopathic activities of T-01 were tested in 14 human and one murine hepatoma cell lines in vitro...
December 30, 2017: Cancer Science
https://www.readbyqxmd.com/read/29282499/quantitative-proteomic-analysis-of-murine-white-adipose-tissue-for-peritoneal-cancer-metastasis
#15
Peter E Feist, Elizabeth A Loughran, M Sharon Stack, Amanda B Hummon
Cancer metastasis risk increases in older individuals, but the mechanisms for this risk increase are unclear. Many peritoneal cancers, including ovarian cancer, preferentially metastasize to peritoneal fat depots. However, there is a dearth of studies exploring aged peritoneal adipose tissue in the context of cancer. Because adipose tissue produces signals which influence several diseases including cancer, proteomics of adipose tissue in aged and young mice may provide insight into metastatic mechanisms. We analyzed mesenteric, omental, and uterine adipose tissue groups from the peritoneal cavities of young and aged C57BL/6J mouse cohorts with a low-fraction SDS-PAGE gelLC-MS/MS method...
December 27, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29280122/-establishment-of-nomogram-model-to-predict-peritoneal-metastasis-in-colon-cancer-patients-without-distant-metastasis-by-preoperative-imaging-examination
#16
Xiaojie Wang, Pan Chi, Huiming Lin, Xingrong Lu, Ying Huang, Zongbin Xu, Shenghui Huang, Yanwu Sun, Daoxiong Ye
OBJECTIVE: To establish a nomogram model to predict the peritoneal metastasis in colon cancer patients without distant metastasis by preoperative imaging examination. METHODS: Clinicopathological data of colon cancer patients without distant metastasis by preoperative imaging examination who underwent surgery in our department between January 2000 and December 2014 were retrospectively analyzed. Predictors of peritoneal carcinomatosis were analyzed by univariate and Logistic multivariate analyses...
December 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29277797/first-clinical-data-of-pressurized-intraperitoneal-aerosol-chemotherapy-pipac-as-salvage-therapy-for-peritoneal-metastatic-biliary-tract-cancer
#17
Thomas A Falkenstein, Thorsten O Götze, Mehdi Ouaissi, Clemens B Tempfer, Urs Giger-Pabst, Cédric Demtröder
BACKGROUND: Patients suffering from peritoneal metastasis of biliary tract cancer were treated with pressurized intraperitoneal aerosol chemotherapy (PIPAC). PATIENTS AND METHODS: This was a study carried out at a single institution, tertiary referral center certified for therapy of peritoneal disease. Retrospective data analysis was performed of prospective data for PIPAC with intra-peritoneal low-dose doxorubicin (1.5 mg/m2) and cisplatin (7.5 mg/m2) delivered at intervals of 6 weeks...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29259012/fih-is-an-oxygen-sensor-in-ovarian-cancer-for-g9a-glp-driven-epigenetic-regulation-of-metastasis-related-genes
#18
Jengmin Kang, Seung-Hyun Shin, Haejin Yoon, June Huh, Hyun-Woo Shin, Yang-Sook Chun, Jong-Wan Park
The prolyl hydroxlyases PHD1-3 and the asparaginly hydroxlyase FIH are oxygen sensors for HIF-driven transcription of hypoxia-induced genes, but whether these sensors affect oxygen-dependent epigenetic regulation more broadly is not known. Here we show that FIH exerts an additional role as an oxygen sensor in epigenetic control by the histone lysine methyltransferases G9a and GLP. FIH hydroxylated and inhibited G9a and GLP under normoxia. When the FIH reaction was limited under hypoxia, G9a and GLP were activated and repressed metastasis suppressor genes, thereby triggering cancer cell migration and peritoneal dissemination of ovarian cancer xenografts...
December 19, 2017: Cancer Research
https://www.readbyqxmd.com/read/29250683/hemorrhagic-polypoid-gastric-and-colonic-metastases-nine-years-after-uterine-leiomyosarcoma-case-report
#19
Nicoleta Puie, Lavinia Patricia Trică, Georgiana Anca Nagy, Ioana Rusu, Alina Simona Şovrea, Carmen Georgiu
INTRODUCTION: Uterine leiomyosarcoma (ULMS) is a rare tumor, representing 1-2% of all uterine malignancies. It is highly aggressive, with high metastatic rate, especially in lungs, peritoneal cavity, retroperitoneum, bones and liver, usually during the first years after diagnosis. CASE PRESENTATION: A 58-year-old woman, with subtotal hysterectomy and bilateral adnexectomy, followed by radiochemotherapy for spindle-type ULMS nine years ago, presented with gastrointestinal bleeding and severe anemia...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29248834/cerebellar-metastasis-of-gastrointestinal-stromal-tumor-a-case-report-and-review-of-the-literature
#20
Mohamed Badri, Mohamed Chabaane, Ghassen Gader, Kamel Bahri, Ihsen Zammel
INTRODUCTION: Intracranial metastases of gastro intestinal tumors are very rare. To the best of our knowledge only few cases were reported on the literature. CASE DESCRIPTION: We describe the case of 66-year-old male that presented with headache and vomiting. Physical examination found a kinetic cerebellar syndrome. Brain CT scan and MRI showed a right cerebellar tumor. Sub-occipital craniotomy was performed and the tumor was completely resected. Surgical outcomes were marked by the occurrence of an abdominal pain two days after brain surgery...
December 13, 2017: International Journal of Surgery Case Reports
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