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Multi-infarct dementia

Jaroslav Pancak, Helena Wagnerova, Andrea Škultéty Szárazová, Andrej Blaho, Ondrej Durovsky, Judita Durovska
OBJECTIVES: Dementias are one of the most serious health and socioeconomic issues. Multi-infarct dementia (MID) and Alzheimer´s type dementia (AD) exhibit differences in cerebrovascular blood flow velocity profiles and in presence of microemboli, detected by transcranial Doppler sonography. MATERIAL AND METHODS: A group of 77 persons was divided into 4 subgroups: 1. subgroup of patients with MID (n=19; 10 male and 9 female, mean age was 74.32±8.30 years); 2. subgroup of patients with AD (n=19; 11 male and 8 female, mean age was 70...
2016: Neuro Endocrinology Letters
Jennifer Gooch, Donna M Wilcock
Vascular cognitive impairment and dementia (VCID) is the most common etiology of dementia in the elderly. Both, vascular and Alzheimer's disease, pathologies work synergistically to create neurodegeneration and cognitive impairments. The main causes of VCID include hemorrhage/microbleed (i.e., hyperhomocysteinemia), cerebral small vessel disease, multi-infarct dementia, severe hypoperfusion (i.e., bilateral common carotid artery stenosis), strategic infarct, angiopathy (i.e., cerebral angiopathy), and hereditary vasculopathy (i...
March 2016: Cellular and Molecular Neurobiology
Olivier Beauchet, Cédric Annweiler, Michele L Callisaya, Anne-Marie De Cock, Jorunn L Helbostad, Reto W Kressig, Velandai Srikanth, Jean-Paul Steinmetz, Helena M Blumen, Joe Verghese, Gilles Allali
BACKGROUND: Poor gait performance predicts risk of developing dementia. No structured critical evaluation has been conducted to study this association yet. The aim of this meta-analysis was to systematically examine the association of poor gait performance with incidence of dementia. METHODS: An English and French Medline search was conducted in June 2015, with no limit of date, using the medical subject headings terms "Gait" OR "Gait Disorders, Neurologic" OR "Gait Apraxia" OR "Gait Ataxia" AND "Dementia" OR "Frontotemporal Dementia" OR "Dementia, Multi-Infarct" OR "Dementia, Vascular" OR "Alzheimer Disease" OR "Lewy Body Disease" OR "Frontotemporal Dementia With Motor Neuron Disease" (Supplementary Concept)...
June 1, 2016: Journal of the American Medical Directors Association
Emilio Pedditizi, Ruth Peters, Nigel Beckett
SCOPE: it has been suggested that overweight/obesity as a risk factor for incident dementia differs between mid-life and later life. We performed a systematic review and meta-analysis of the up-to-date current literature to assess this. SEARCH METHODS: inclusion criteria included epidemiological longitudinal studies published up to September 2014, in participants without cognitive impairment based on evidence of cognitive assessment and aged 30 or over at baseline assessment with at least 2 years of follow-up...
January 2016: Age and Ageing
Joachim Schrader
No abstract text is available yet for this article.
October 2015: Deutsche Medizinische Wochenschrift
R L Levine, J C Jones, N Bee
We sought to determine whether clinical features, stroke profiles, and cranial computed tomography (CCT) findings differed in nondemented and demented Parkinson's disease (PD) patients. Data were collected from our previously published case-control review of 119 idiopathic PD patients discharged from our Veterans Affairs Medical Center Neurology Service from 1982 through 1990. Historical, physical, age, age at onset of PD, duration of PD, motor severity, frequency of ischemic stroke and stroke risk factors, modified Hachinski Ischemic Score (MHIS), and CCT findings were recorded...
1994: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
S Matsuoka, Y Fukuuchi, M Tomita, N Tanahashi, H Takeda
We reported previously that erythrocyte aggregability (RBC-A) is enhanced in patients with cerebral infarction. The purpose of the present study was to examine whether or not differences in RBC-A exist between multi-infarct dementia (MID) and Alzheimer's disease. The subjects comprised 16 patients with MID (7 males and 9 females, 73 ± 11 years old) who had Hachinski's ischemic scores of 7 or more and displayed multiple infarctions on brain computed tomography and 18 patients with Alzheimer's disease (8 males and 10 females, 70 ± 8 years old) who were diagnosed using the criteria proposed by the NINCDS-ADRDA Work Group...
1993: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
S Takagi, W Takahashi, M Nagayama, Y Shinohara
No abstract text is available yet for this article.
1992: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
B Chandra
A double-blind placebo controlled trial was conducted in 146 patients with MID who were allocated randomly into two groups, one receiving 250 mg citi-choline three times day and the other receiving isotonic saline three times a day for 2 months. The group treated with citicholine showed a marked improvement on the MMSE compared with the placebo group. No significant side effects were noted.
1992: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
H Lechner, M Walzl, B Walzl, G Kleinert, W Freidel
HELP is capable of lowering LDL, cholesterol, triglycerides, and fibrinogen. It has been proven that HELP application has an impact on MID by decreasing plasma fibrinogen, cholesterol, LDL, triglycerides, thus also reducing whole-blood plasma viscosity, plasma fibrinogen, and red cell transit time. It has been shown that a single HELP treatment in MID is followed by an improvement of the scores obtained from the rating scales employed (Mathew, Mini Mental State Examination, Activities of Daily Living) for as long as 10 days, which was supported by comparison with the scores of a control group...
1992: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
A Alavi, A Newberg, E Souder, M Reivich
No abstract text is available yet for this article.
1992: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
J Kawamura, J S Meyer, Y Terayama, S Weathers
Longitudinal measurements of local cerebral blood flow (LCBF) were performed in 13 patients with multi-infarct dementia (MID) utilizing the xenon-enhanced computed tomography-CBF method. Subjects were divided into two groups: a group consisting of five patients with MID who deteriorated (aged 60.6 ± 5.3 years) and whose CCSE scores decreased and a stable group comprised of eight patients (aged 64.5 ± 4.5 years) whose CCSE scores did not change. Mean intervals between first and second LCBF measurements were 663 ± 182 days for the deteriorated group and 795 ± 495 days for the stable group...
1991: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
M Walzl, B Walzl, H Lechner
A trial was undertaken with 44 patients with the diagnosis of cerebral multi-infarct dementia. Of these, 24 had been exposed to single heparin-induced extracorporeal low-density lipoprotein (LDL) precipitation (HELP) whereby an immediate, safe, and statistically significant reduction of total cholesterol, LDL, triglycerides, fibrinogen (<0.0001 each), lipoprotein (a) (p < 0.003), whole-blood viscosity (p < 0.005 at high shear and p < 0.007 at low shear rate), plasma viscosity (p < 0.0002) and red cell transit time (p < 0...
1994: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Catherine C Price, Jared J Tanner, Ilona M Schmalfuss, Babette Brumback, Kenneth M Heilman, David J Libon
BACKGROUND: There is remarkable heterogeneity in clinical Alzheimer's disease (AD) or vascular dementia (VaD). OBJECTIVES: 1) To statistically examine neuropsychological data to determine dementia subgroups for individuals clinically diagnosed with AD or VaD and then 2) examine group differences in specific gray/white matter regions of interest. METHODS: A k-means cluster analysis requested a 3-group solution from neuropsychological data acquired from individuals diagnosed clinically with AD/VaD...
2015: Journal of Alzheimer's Disease: JAD
T Hawro, A Bogucki, M Krupińska-Kun, M Maurer, A Woźniacka
OBJECTIVE: Neuropsychiatric (NP) lupus, a common manifestation of systemic lupus erythematosus (SLE), is still insufficiently understood, in part, because of the lack of specific biomarkers. Neuron specific enolase (NSE), an important neuronal glycolytic enzyme, shows increased serum levels following acute brain injury, and decreased serum levels in several chronic disorders of the nervous system, including multi infarct dementia, multiple sclerosis and depression. The aim of the study was to evaluate serum NSE levels in SLE patients with and without nervous system involvement, and in healthy controls, and to assess the correlation of NSE serum levels of patients with neuropsychiatric systemic lupus erythematosus (NPSLE) with clinical parameters...
December 2015: Lupus
Tanju Surmeli, Emin Eralp, Ilhan Mustafazade, Hadi Kos, Gül Elif Özer, Orkun H Surmeli
Dementia is a debilitating degenerative disorder where the sufferer's cognitive abilities decline over time, depending on the type of dementia. The more common types of dementia include Alzheimer's disease and vascular or multi-infarct dementia. In this study, 20 subjects with dementia (9 of Alzheimer's type, and 11 with vascular dementia) were treated using qEEG-guided neurofeedback training. The Mini Mental Status Examination (MMSE) was used as the primary outcome measure. The results showed an increase of the MMSE scores for all subjects regardless of dementia type with an average MMSE score increase of 6 points, which was found to be significant...
April 2016: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
M S Bhatia, Priyanka Gautam, Jaswinder Kaur
Ekbom Syndrome is characterized by delusion that small living being infests skin. The clinical profile of this disorder has shown it to be associated with organic conditions. Neuroimaging studies implicate putamen as the brain structure involved in the pathophysiology. These are also known as organic delusional disorder and provide an opportunity to study biological causation of delusional disorder. We report a patient presented with a complaint of insects crawling on her body for last two years. She collected the peeled skin in a jar and claimed that these are insects...
April 2015: Journal of Clinical and Diagnostic Research: JCDR
Fang Li, Chao-Qun Yan, Li-Ting Lin, Hui Li, Xiang-Hong Zeng, Yi Liu, Si-Qi Du, Wen Zhu, Cun-Zhi Liu
BACKGROUND: Decreased cognition is recognized as one of the most severe and consistent behavioral impairments in dementia. Experimental studies have reported that acupuncture may improve cognitive deficits, relieve vascular dementia (VD) symptoms, and increase cerebral perfusion and electrical activity. METHODS: Multi-infarction dementia was modeled in rats with 3% microemboli saline suspension. Two weeks after acupuncture at Zusanli (ST36), all rats were subjected to a hidden platform trial to test their 3-day spatial memory using the Morris water maze test...
2015: BMC Complementary and Alternative Medicine
Pablo J Landi, Gisell A Torrejón Fernández, Carla Gazzi
No abstract text is available yet for this article.
2015: Medicina
Antje Schmidt, Kai Diederich, Jan-Kolja Strecker, Birgit Geng, Maike Hoppen, Thomas Duning, Wolf-Rüdiger Schäbitz, Jens Minnerup
BACKGROUND AND PURPOSE: In spite of its high disease burden, there is no specific treatment for multi-infarct dementia. The preclinical evaluation of candidate drugs is limited because an appropriate animal model is lacking. Therefore, we aimed to evaluate whether a mouse model of recurrent photothrombotic stroke is suitable for the preclinical investigation of multi-infarct dementia. METHODS: Recurrent photothrombotic cortical infarcts were induced in 25 adult C57BL/6 mice...
April 2015: Stroke; a Journal of Cerebral Circulation
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