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Multi-infarct dementia

R C Hamdy, A Kinser, T Kendall-Wilson, A Depelteau, K Whalen, J Culp
Driving is a symbol of autonomy and independence, eagerly awaited during adolescence, cherished during adulthood and reluctantly rescinded during old age. It is nevertheless an individual's privilege, not right, especially as driving may affect other drivers and pedestrians on the road. It is therefore not only the individual patient who is at stake but essentially the entire community. In this case scenario, we describe the situation that arose when a patient with multi-infarct dementia wanted to go for a drive and his son and grandson tried to convince him that he could no longer drive...
January 2018: Gerontology & Geriatric Medicine
Erin McKay, Scott E Counts
BACKGROUND: Multi-infarct dementia (MID), a prominent subtype of vascular dementia (VaD), has only achieved recognition in the last 4 decades. Since its original description, the characterization, etiological understanding, and therapeutic direction of MID and other VaD subtypes has progressed at an astounding rate. SUMMARY: This paper divides the landmark discoveries and emergence of new research strategies for MID into decade-defining patterns so that a condensed picture of the total history of MID and its eventual inclusion as a VaD subtype emerges...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
Maija Siitonen, Anne Börjesson-Hanson, Minna Pöyhönen, Ari Ora, Petra Pasanen, Jose Bras, Silke Kern, Jürgen Kern, Oluf Andersen, Horia Stanescu, Robert Kleta, Marc Baumann, Rajesh Kalaria, Hannu Kalimo, Andy Singleton, John Hardy, Matti Viitanen, Liisa Myllykangas, Rita Guerreiro
No abstract text is available yet for this article.
May 1, 2017: Brain: a Journal of Neurology
Albert Stuart Reece, Gary Kenneth Hulse
BACKGROUND: Whilst the hypothalamic-pituitary-adrenal (HPA) Axis is a major stress axis, and is necessarily perturbed in opioid dependency, and stress is a major contributor to aging mechanisms, the HPA axis has not been studied in opioid dependency in an age-dependent manner. OBJECTIVE: Hypothesis - Differences in age dependent levels of HPA components. DESIGN: Cross-sectional comparison of general medical and opioid dependent patients (ODP, GMP)...
September 2016: Neuro Endocrinology Letters
W Reith, S Roumia, P Dietrich
CLINICAL/METHODICAL ISSUE: Cerebellar syndromes result in distinct clinical symptoms, such as ataxia, dysarthria, dysmetria, intention tremor and eye movement disorders. STANDARD RADIOLOGICAL METHODS: In addition to the medical history and clinical examination, imaging is particularly important to differentiate other diseases, such as hydrocephalus and multi-infarct dementia from degenerative cerebellar diseases. Degenerative diseases with cerebellar involvement include Parkinson's disease, multiple system atrophy as well as other diseases including spinocerebellar ataxia...
November 2016: Der Radiologe
Jaroslav Pancak, Helena Wagnerova, Andrea Škultéty Szárazová, Andrej Blaho, Ondrej Durovsky, Judita Durovska
OBJECTIVES: Dementias are one of the most serious health and socioeconomic issues. Multi-infarct dementia (MID) and Alzheimer´s type dementia (AD) exhibit differences in cerebrovascular blood flow velocity profiles and in presence of microemboli, detected by transcranial Doppler sonography. MATERIAL AND METHODS: A group of 77 persons was divided into 4 subgroups: 1. subgroup of patients with MID (n=19; 10 male and 9 female, mean age was 74.32±8.30 years); 2. subgroup of patients with AD (n=19; 11 male and 8 female, mean age was 70...
2016: Neuro Endocrinology Letters
Jennifer Gooch, Donna M Wilcock
Vascular cognitive impairment and dementia (VCID) is the most common etiology of dementia in the elderly. Both, vascular and Alzheimer's disease, pathologies work synergistically to create neurodegeneration and cognitive impairments. The main causes of VCID include hemorrhage/microbleed (i.e., hyperhomocysteinemia), cerebral small vessel disease, multi-infarct dementia, severe hypoperfusion (i.e., bilateral common carotid artery stenosis), strategic infarct, angiopathy (i.e., cerebral angiopathy), and hereditary vasculopathy (i...
March 2016: Cellular and Molecular Neurobiology
Olivier Beauchet, Cédric Annweiler, Michele L Callisaya, Anne-Marie De Cock, Jorunn L Helbostad, Reto W Kressig, Velandai Srikanth, Jean-Paul Steinmetz, Helena M Blumen, Joe Verghese, Gilles Allali
BACKGROUND: Poor gait performance predicts risk of developing dementia. No structured critical evaluation has been conducted to study this association yet. The aim of this meta-analysis was to systematically examine the association of poor gait performance with incidence of dementia. METHODS: An English and French Medline search was conducted in June 2015, with no limit of date, using the medical subject headings terms "Gait" OR "Gait Disorders, Neurologic" OR "Gait Apraxia" OR "Gait Ataxia" AND "Dementia" OR "Frontotemporal Dementia" OR "Dementia, Multi-Infarct" OR "Dementia, Vascular" OR "Alzheimer Disease" OR "Lewy Body Disease" OR "Frontotemporal Dementia With Motor Neuron Disease" (Supplementary Concept)...
June 1, 2016: Journal of the American Medical Directors Association
Emilio Pedditizi, Ruth Peters, Nigel Beckett
SCOPE: it has been suggested that overweight/obesity as a risk factor for incident dementia differs between mid-life and later life. We performed a systematic review and meta-analysis of the up-to-date current literature to assess this. SEARCH METHODS: inclusion criteria included epidemiological longitudinal studies published up to September 2014, in participants without cognitive impairment based on evidence of cognitive assessment and aged 30 or over at baseline assessment with at least 2 years of follow-up...
January 2016: Age and Ageing
Joachim Schrader
No abstract text is available yet for this article.
October 2015: Deutsche Medizinische Wochenschrift
R L Levine, J C Jones, N Bee
We sought to determine whether clinical features, stroke profiles, and cranial computed tomography (CCT) findings differed in nondemented and demented Parkinson's disease (PD) patients. Data were collected from our previously published case-control review of 119 idiopathic PD patients discharged from our Veterans Affairs Medical Center Neurology Service from 1982 through 1990. Historical, physical, age, age at onset of PD, duration of PD, motor severity, frequency of ischemic stroke and stroke risk factors, modified Hachinski Ischemic Score (MHIS), and CCT findings were recorded...
1994: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
S Matsuoka, Y Fukuuchi, M Tomita, N Tanahashi, H Takeda
We reported previously that erythrocyte aggregability (RBC-A) is enhanced in patients with cerebral infarction. The purpose of the present study was to examine whether or not differences in RBC-A exist between multi-infarct dementia (MID) and Alzheimer's disease. The subjects comprised 16 patients with MID (7 males and 9 females, 73 ± 11 years old) who had Hachinski's ischemic scores of 7 or more and displayed multiple infarctions on brain computed tomography and 18 patients with Alzheimer's disease (8 males and 10 females, 70 ± 8 years old) who were diagnosed using the criteria proposed by the NINCDS-ADRDA Work Group...
1993: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
S Takagi, W Takahashi, M Nagayama, Y Shinohara
No abstract text is available yet for this article.
1992: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
B Chandra
A double-blind placebo controlled trial was conducted in 146 patients with MID who were allocated randomly into two groups, one receiving 250 mg citi-choline three times day and the other receiving isotonic saline three times a day for 2 months. The group treated with citicholine showed a marked improvement on the MMSE compared with the placebo group. No significant side effects were noted.
1992: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
H Lechner, M Walzl, B Walzl, G Kleinert, W Freidel
HELP is capable of lowering LDL, cholesterol, triglycerides, and fibrinogen. It has been proven that HELP application has an impact on MID by decreasing plasma fibrinogen, cholesterol, LDL, triglycerides, thus also reducing whole-blood plasma viscosity, plasma fibrinogen, and red cell transit time. It has been shown that a single HELP treatment in MID is followed by an improvement of the scores obtained from the rating scales employed (Mathew, Mini Mental State Examination, Activities of Daily Living) for as long as 10 days, which was supported by comparison with the scores of a control group...
1992: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
A Alavi, A Newberg, E Souder, M Reivich
No abstract text is available yet for this article.
1992: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
J Kawamura, J S Meyer, Y Terayama, S Weathers
Longitudinal measurements of local cerebral blood flow (LCBF) were performed in 13 patients with multi-infarct dementia (MID) utilizing the xenon-enhanced computed tomography-CBF method. Subjects were divided into two groups: a group consisting of five patients with MID who deteriorated (aged 60.6 ± 5.3 years) and whose CCSE scores decreased and a stable group comprised of eight patients (aged 64.5 ± 4.5 years) whose CCSE scores did not change. Mean intervals between first and second LCBF measurements were 663 ± 182 days for the deteriorated group and 795 ± 495 days for the stable group...
1991: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
M Walzl, B Walzl, H Lechner
A trial was undertaken with 44 patients with the diagnosis of cerebral multi-infarct dementia. Of these, 24 had been exposed to single heparin-induced extracorporeal low-density lipoprotein (LDL) precipitation (HELP) whereby an immediate, safe, and statistically significant reduction of total cholesterol, LDL, triglycerides, fibrinogen (<0.0001 each), lipoprotein (a) (p < 0.003), whole-blood viscosity (p < 0.005 at high shear and p < 0.007 at low shear rate), plasma viscosity (p < 0.0002) and red cell transit time (p < 0...
1994: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Catherine C Price, Jared J Tanner, Ilona M Schmalfuss, Babette Brumback, Kenneth M Heilman, David J Libon
BACKGROUND: There is remarkable heterogeneity in clinical Alzheimer's disease (AD) or vascular dementia (VaD). OBJECTIVES: 1) To statistically examine neuropsychological data to determine dementia subgroups for individuals clinically diagnosed with AD or VaD and then 2) examine group differences in specific gray/white matter regions of interest. METHODS: A k-means cluster analysis requested a 3-group solution from neuropsychological data acquired from individuals diagnosed clinically with AD/VaD...
2015: Journal of Alzheimer's Disease: JAD
T Hawro, A Bogucki, M Krupińska-Kun, M Maurer, A Woźniacka
OBJECTIVE: Neuropsychiatric (NP) lupus, a common manifestation of systemic lupus erythematosus (SLE), is still insufficiently understood, in part, because of the lack of specific biomarkers. Neuron specific enolase (NSE), an important neuronal glycolytic enzyme, shows increased serum levels following acute brain injury, and decreased serum levels in several chronic disorders of the nervous system, including multi infarct dementia, multiple sclerosis and depression. The aim of the study was to evaluate serum NSE levels in SLE patients with and without nervous system involvement, and in healthy controls, and to assess the correlation of NSE serum levels of patients with neuropsychiatric systemic lupus erythematosus (NPSLE) with clinical parameters...
December 2015: Lupus
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