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Marc Giovannini

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https://www.readbyqxmd.com/read/28469359/probe-confocal-laser-endomicroscopy-in-the-therapeutic-endoscopic-management-of-barrett-s-dysplasia
#1
Fabrice Caillol, Sebastien Godat, Flora Poizat, Aurélie Auttret, Christian Pesenti, Erwan Bories, Jean Phillipe Ratone, Marc Giovannini
BACKGROUND: Endoscopic management of Barrett's esophagus (BE) depends on the histological stage of BE and includes the following: follow up, endotherapy with thermal ablation, and piecemeal or monobloc endoscopic resection (ER). We know that biopsies are unreliable in 20-75% of cases. The aim of our study was to evaluate the efficiency of probe confocal laser endomicroscopy (pCLE) in the diagnosis of the histological stage of BE, compared with the final histological results after ER. METHODS: This retrospective study was based on a prospective registry of patients referred for management of BE-associated dysplasia...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/28456389/development-of-reliable-and-validated-tools-to-evaluate-technical-resuscitation-skills-in-a-pediatric-simulation-setting-resuscitation-and-emergency-simulation-checklist-for-assessment-in-pediatrics
#2
Camille Faudeux, Antoine Tran, Audrey Dupont, Jonathan Desmontils, Isabelle Montaudié, Jean Bréaud, Marc Braun, Jean-Paul Fournier, Etienne Bérard, Noémie Berlengi, Cyril Schweitzer, Hervé Haas, Hervé Caci, Amélie Gatin, Lisa Giovannini-Chami
OBJECTIVES: To develop a reliable and validated tool to evaluate technical resuscitation skills in a pediatric simulation setting. STUDY DESIGN: Four Resuscitation and Emergency Simulation Checklist for Assessment in Pediatrics (RESCAPE) evaluation tools were created, following international guidelines: intraosseous needle insertion, bag mask ventilation, endotracheal intubation, and cardiac massage. We applied a modified Delphi methodology evaluation to binary rating items...
April 26, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28275007/gene-expression-profiling-of-patient-derived-pancreatic-cancer-xenografts-predicts-sensitivity-to-the-bet-bromodomain-inhibitor-jq1-implications-for-individualized-medicine-efforts
#3
Benjamin Bian, Martin Bigonnet, Odile Gayet, Celine Loncle, Aurélie Maignan, Marine Gilabert, Vincent Moutardier, Stephane Garcia, Olivier Turrini, Jean-Robert Delpero, Marc Giovannini, Philippe Grandval, Mohamed Gasmi, Mehdi Ouaissi, Veronique Secq, Flora Poizat, Rémy Nicolle, Yuna Blum, Laetitia Marisa, Marion Rubis, Jean-Luc Raoul, James E Bradner, Jun Qi, Gwen Lomberk, Raul Urrutia, Andres Saul, Nelson Dusetti, Juan Iovanna
c-MYC controls more than 15% of genes responsible for proliferation, differentiation, and cellular metabolism in pancreatic as well as other cancers making this transcription factor a prime target for treating patients. The transcriptome of 55 patient-derived xenografts show that 30% of them share an exacerbated expression profile of MYC transcriptional targets (MYC-high). This cohort is characterized by a high level of Ki67 staining, a lower differentiation state, and a shorter survival time compared to the MYC-low subgroup...
April 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28196390/long-term-outcome-of-endoscopic-ultrasound-guided-pelvic-abscess-drainage-a-two-center-series
#4
Laurent Poincloux, Fabrice Caillol, Christophe Allimant, Erwan Bories, Christian Pesenti, Aurélien Mulliez, Frederic Faure, Olivier Rouquette, Michel Dapoigny, Armando Abergel, Marc Giovannini
Background and study aim Endoscopic ultrasound (EUS)-guided pelvic abscess drainage has been reported but long-term data remain limited. This two-center study evaluated long-term outcome of EUS-guided pelvic abscess drainage. Patients and methods Between May 2003 and December 2015, 37 consecutive patients were treated for perirectal or perisigmoid abscesses via EUS-guided drainage using plastic or lumen-apposing metal stent (LAMS). Clinical success was defined as complete resolution of the abscess on follow-up computed tomography (CT) scan at 4 weeks with symptom relief...
May 2017: Endoscopy
https://www.readbyqxmd.com/read/28078459/endotherapy-in-case-of-relapse-of-neoplastic-barrett-s-esophagus-after-successful-initial-endoscopic-resection
#5
Sébastien Godat, Fabrice Caillol, Aurélie Autret, Erwan Bories, Christian Pesenti, Jean Philippe Ratone, Chiara De Cassan, Flora Poizat, Marc Giovannini
BACKGROUND: Endotherapy in cases of neoplastic Barrett esophagus (BE) relapse after successful initial endoscopic management is commonly accepted, but few studies analyze this topic and also take into account the metachronous lesions. AIMS: To evaluate the efficiency of endotherapy in the case of neoplastic BE relapse after successful complete endoscopic eradication of neoplastic BE and metaplastic BE. METHODS: Retrospective review of medical records was collected in a computerized and prospective manner between 2000 and 2015, in a single tertiary care center...
January 11, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28042239/oral-steroid-prophylaxis-is-effective-in-preventing-esophageal-strictures-after-large-endoscopic-resection
#6
Jean-Philippe Ratone, Erwan Bories, Fabrice Caillol, Christian Pesenti, Sebastien Godat, Flora Poizat, Chiara De Cassan, Marc Giovannini
BACKGROUND: Strictures are frequent complications of large endoscopic mucosal resections (EMR) and endoscopic submucosal dissections of the esophagus. Local or systemic steroid therapy has shown promise in the prevention of secondary stenosis. The aim of this study was to evaluate the safety and efficacy of systemic steroid therapy following endoscopic resection of at least hemi-circumferential esophageal mucosa. METHODS: This was a single-center retrospective study in a tertiary center...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/28009687/eus-guided-versus-percutaneous-gallbladder-drainage-isn-t-it-time-to-convert
#7
Amy Tyberg, Monica Saumoy, Enrique V Sequeiros, Marc Giovannini, Everson Artifon, Anthony Teoh, Jose Nieto, Amit P Desai, Nikhil A Kumta, Monica Gaidhane, Reem Z Sharaiha, Michel Kahaleh
BACKGROUND AND AIMS: Endoscopic ultrasound-guided drainage (EUS-GLB) is a minimally invasive option for patients with cholecystitis who are poor surgical candidates. Compared with percutaneous drainage (PC-GLB), earlier studies have demonstrated similar efficacy with improved quality of life. We present a multicenter, international experience comparing PC-GLB and EUS-GLB in nonsurgical patients with cholecystitis. METHODS: All patients who underwent either PC-GLB drainage or EUS-GLB drainage from 7 centers between January 2010 and December 2015 were included...
December 22, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27576181/endoscopic-ultrasound-guided-needle-based-confocal-laser-endomicroscopy-in-solid-pancreatic-masses
#8
Marc Giovannini, Fabrice Caillol, Geneviève Monges, Flora Poizat, Anne-Isabelle Lemaistre, Bertrand Pujol, Damien Lucidarme, Laurent Palazzo, Bertrand Napoléon
BACKGROUND AND STUDY AIMS: The differential diagnosis of solid pancreatic masses by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is currently suboptimal in centers that are not equipped with rapid on-site evaluation. Needle-based confocal laser endomicroscopy (nCLE) enables real-time in vivo microscopic imaging during endoscopy. This study aimed to describe nCLE interpretation criteria for the characterization of pancreatic masses, with histopathological correlation, and to perform the first validation of these criteria...
October 2016: Endoscopy
https://www.readbyqxmd.com/read/27462772/a-pancreatic-ductal-adenocarcinoma-subpopulation-is-sensitive-to-fk866-an-inhibitor-of-nampt
#9
Marine Barraud, Jonathan Garnier, Celine Loncle, Odile Gayet, Charlotte Lequeue, Sophie Vasseur, Benjamin Bian, Pauline Duconseil, Marine Gilabert, Martin Bigonnet, Aurélie Maignan, Vincent Moutardier, Stephane Garcia, Olivier Turrini, Jean-Robert Delpero, Marc Giovannini, Philippe Grandval, Mohamed Gasmi, Mehdi Ouaissi, Veronique Secq, Flora Poizat, Nicolas Guibert, Juan Iovanna, Nelson Dusetti
Treating pancreatic cancer is extremely challenging due to multiple factors, including chemoresistance and poor disease prognosis. Chemoresistance can be explained by: the presence of a dense stromal barrier leading to a lower vascularized condition, therefore limiting drug delivery; the huge intra-tumoral heterogeneity; and the status of epithelial-to-mesenchymal transition. These factors are highly variable between patients making it difficult to predict responses to chemotherapy. Nicotinamide phosphoribosyl transferase (NAMPT) is the main enzyme responsible for recycling cytosolic NAD+ in hypoxic conditions...
August 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27460387/eus-guided-pancreatic-drainage-for-pancreatic-strictures-after-failed-ercp-a-multicenter-international-collaborative-study
#10
Amy Tyberg, Reem Z Sharaiha, Prashant Kedia, Nikhil Kumta, Monica Gaidhane, Everson Artifon, Marc Giovannini, Michel Kahaleh
BACKGROUND AND AIMS: Endoscopic retrograde pancreatography (ERP) is considered first-line therapy for management of symptomatic pancreatic duct obstruction. Technical failure with ERP occurs when the main pancreatic duct cannot be cannulated. EUS-guided drainage of the pancreatic duct is a minimally invasive alternative to surgery for failed conventional ERP. We present an international, multicenter study on the safety and efficacy of EUS-guided pancreatic drainage (EUS-PD) for patients who fail conventional endoscopic therapy...
January 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27409435/improving-the-axial-and-lateral-resolution-of-three-dimensional-fluorescence-microscopy-using-random-speckle-illuminations
#11
Awoke Negash, Simon Labouesse, Nicolas Sandeau, Marc Allain, Hugues Giovannini, Jérôme Idier, Rainer Heintzmann, Patrick C Chaumet, Kamal Belkebir, Anne Sentenac
We consider a fluorescence microscope in which several three-dimensional images of a sample are recorded for different speckle illuminations. We show, on synthetic data, that by summing the positive deconvolution of each speckle image, one obtains a sample reconstruction with axial and transverse resolutions that compare favorably to that of an ideal confocal microscope.
June 1, 2016: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/27328985/international-collaborative-study-on-eus-guided-gallbladder-drainage-are-we-ready-for-prime-time
#12
Michel Kahaleh, Manuel Perez-Miranda, Everson L Artifon, Reem Z Sharaiha, Prashant Kedia, Irene Peñas, Carlos De la Serna, Nikhil A Kumta, Fernando Marson, Monica Gaidhane, Christine Boumitri, Viviana Parra, Carlos M Rondon Clavo, Marc Giovannini
BACKGROUND: Cholecystectomy remains the gold standard treatment of cholecystitis. Endoscopic treatment of cholecystitis includes transpapillary gallbladder drainage. Recently, endoscopic ultrasound-guided transmural drainage of the gallbladder (EUS-GBD) has been reported. This study reports the cumulative experience of an international group performing EUS-GBD. METHODS: Cases of EUS-GBD from January 2012 to November 2013 from 3 tertiary-care institutions were captured in a registry...
September 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27299638/papillary-cannulation-and-sphincterotomy-techniques-at-ercp-european-society-of-gastrointestinal-endoscopy-esge-clinical-guideline
#13
Pier Alberto Testoni, Alberto Mariani, Lars Aabakken, Marianna Arvanitakis, Erwan Bories, Guido Costamagna, Jacques Devière, Mario Dinis-Ribeiro, Jean-Marc Dumonceau, Marc Giovannini, Tibor Gyokeres, Michael Hafner, Jorma Halttunen, Cesare Hassan, Luis Lopes, Ioannis S Papanikolaou, Tony C Tham, Andrea Tringali, Jeanin van Hooft, Earl J Williams
This Guideline is an official statement of the European Society of Gastrointestinal Endoscopy (ESGE). It provides practical advice on how to achieve successful cannulation and sphincterotomy at minimum risk to the patient. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system was adopted to define the strength of recommendations and the quality of evidence. Main recommendations 1 ESGE suggests that difficult biliary cannulation is defined by the presence of one or more of the following: more than 5 contacts with the papilla whilst attempting to cannulate; more than 5 minutes spent attempting to cannulate following visualization of the papilla; more than one unintended pancreatic duct cannulation or opacification (low quality evidence, weak recommendation)...
July 2016: Endoscopy
https://www.readbyqxmd.com/read/27286454/heterogeneity-of-metastatic-pancreatic-adenocarcinoma-lung-metastasis-show-better-prognosis-than-liver-metastasis-a-case-control-study
#14
Claire Decoster, Marine Gilabert, Aurélie Autret, Olivier Turrini, Sandrine Oziel-Taieb, Flora Poizat, Marc Giovannini, Patrice Viens, Juan Iovanna, Jean-Luc Raoul
The prognosis of metastatic pancreatic ductal adenocarcinoma (PDAC) is grim, with a median overall survival of under 1 year. In our clinical practice, we observed a few cases of isolated lung metastases from PDAC with unusually long outcomes. We compared these cases in a case-control study of lung-only vs. liver-only metastases from PDAC.From our database, we found 37 cases of lung-only metastases and paired them with 37 cases of liver-only metastases by age, tumor location and treatment.The lung-only group differed significantly from the liver-only group with respect to the following parameters: female predominance, more metachronous cases, fewer nodules per patient, and smaller increases in tumor markers...
July 19, 2016: Oncotarget
https://www.readbyqxmd.com/read/27230854/xpr1-mutations-are-a-rare-cause-of-primary-familial-brain-calcification
#15
Mathieu Anheim, Uriel López-Sánchez, Donatella Giovannini, Anne-Claire Richard, Jawida Touhami, Ludovic N'Guyen, Gabrielle Rudolf, Anne Thibault-Stoll, Thierry Frebourg, Didier Hannequin, Dominique Campion, Jean-Luc Battini, Marc Sitbon, Gaël Nicolas
Mutations in XPR1, a gene encoding an inorganic phosphate exporter, have recently been identified in patients with primary familial brain calcification (PFBC). Using Sanger sequencing, we screened XPR1 in 18 unrelated patients with PFBC and no SLC20A2, PDGFB, or PDGFRB mutation. XPR1 variants were tested in an in vitro physiological complementation assay and patient blood cells were assessed ex vivo for phosphate export. We identified a novel c.260T > C, p.(Leu87Pro) XPR1 variant in a 41-year-old man complaining of micrographia and dysarthria and demonstrating mild parkinsonism, cerebellar ataxia and executive dysfunction...
August 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27157448/frey-syndrome
#16
Sibylle Blanc, Thierry Bourrier, Franck Boralevi, Dominique Sabouraud-Leclerc, Nhân Pham-Thi, Laure Couderc, Antoine Deschildre, Guy Dutau, Marc Albertini, Antoine Tran, Lisa Giovannini-Chami
OBJECTIVE: To describe the features of Frey syndrome (auriculotemporal nerve dysfunction with gustatory flushing) in childhood. STUDY DESIGN: A multicenter, retrospective, descriptive observational national case series study was conducted with the help of French academic societies. Diagnostic criteria were based on clinical history, and sometimes also on photographs or provocation tests. RESULTS: Forty-eight cases were identified, with 2 subtypes: 35 unilateral and 13 bilateral...
July 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27129553/neoplastic-barrett-s-oesophagus-and-long-term-follow-up-after-endoscopic-therapy-complete-histological-eradication-of-barrett-associated-with-high-grade-dysplasia-significantly-decreases-neoplasia-relapse
#17
Fabrice Caillol, Sebastien Godat, Aurelie Autret, Erwan Bories, Christian Pesenti, Jean Phillippe Ratone, Flora Poizat, Jerome Guiramand, Jean Robert Delpero, Marc Giovannini
BACKGROUND AND AIMS: Endotherapy (ET) has replaced surgery as the first-line treatment of high-grade dysplasia (HGD)/superficial ECA (ECAs) from Barrett's oesophagus (BO). However, long-term follow-up and predictive factors of relapse are not so well studied. The aim of the following study was to evaluate the efficiency of ET for treatment of HGD/ECAs and to determine factors of long-term efficiency. METHODS: ET procedures were manually reported and registered in a hospital data base from March 2000 to July 2010...
December 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27107061/expression-of-genes-with-copy-number-alterations-and-survival-of-patients-with-pancreatic-adenocarcinoma
#18
David J Birnbaum, François Bertucci, Pascal Finetti, José Adélaïde, Marc Giovannini, Olivier Turrini, Jean Robert Delpero, Jean Luc Raoul, Max Chaffanet, Vincent Moutardier, Daniel Birnbaum, Emilie Mamessier
BACKGROUND/AIM: Individual molecular information might improve management of pancreatic adenocarcinoma. To identify actionable genes, at the transcriptional level, we investigated candidate genes that we had previously identified using array-comparative genomic hybridization (aCGH). MATERIALS AND METHODS: We collected 10 public gene-expression datasets, gathering a total of 524 pancreatic samples (105 normal and 419 malignant tissues). Based on our previous aCGH analysis, we searched for genes differentially expressed between normal and malignant samples and genes associated with survival...
May 2016: Cancer Genomics & Proteomics
https://www.readbyqxmd.com/read/27087954/efficiency-and-safety-of-endoscopic-resection-in-the-management-of-subepithelial-lesions-of-the-stomach
#19
Sébastien Godat, Maxime Robert, Fabrice Caillol, Erwan Bories, Christian Pesenti, Chiara De Cassan, Jean Philippe Ratone, Flora Poizat, Marc Giovannini
BACKGROUND: Gastric subepithelial tumors represent a diagnostic and therapeutic challenge, given their histologic heterogeneity and potential malignant behavior. OBJECTIVE: The objective of this article is to evaluate the interest, efficiency and safety of endoscopic resection for subepithelial gastric lesions of size <20 mm. METHODS: We conducted a single-center retrospective study in a tertiary care center. RESULTS: A total of 33 lesions (10 malignant/23 benign lesions) were studied...
April 2016: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/26949002/probe-based-confocal-laser-endomicroscopy-for-the-differential-diagnosis-of-gastric-tubular-adenoma-and-intestinal-metaplasia-in-a-patient-with-severe-atrophic-pangastritis
#20
Elisa Ryoka Baba, Adriana Vaz Safatle-Ribeiro, Gabriela Ferreira Paduani, Marc Giovannini, Fauze Maluf-Filho
No abstract text is available yet for this article.
July 2016: Gastrointestinal Endoscopy
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