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Marc Giovannini

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https://www.readbyqxmd.com/read/29773832/distinct-epigenetic-landscapes-underlie-the-pathobiology-of-pancreatic-cancer-subtypes
#1
Gwen Lomberk, Yuna Blum, Rémy Nicolle, Asha Nair, Krutika Satish Gaonkar, Laetitia Marisa, Angela Mathison, Zhifu Sun, Huihuang Yan, Nabila Elarouci, Lucile Armenoult, Mira Ayadi, Tamas Ordog, Jeong-Heon Lee, Gavin Oliver, Eric Klee, Vincent Moutardier, Odile Gayet, Benjamin Bian, Pauline Duconseil, Marine Gilabert, Martin Bigonnet, Stephane Garcia, Olivier Turrini, Jean-Robert Delpero, Marc Giovannini, Philippe Grandval, Mohamed Gasmi, Veronique Secq, Aurélien De Reyniès, Nelson Dusetti, Juan Iovanna, Raul Urrutia
Recent studies have offered ample insight into genome-wide expression patterns to define pancreatic ductal adenocarcinoma (PDAC) subtypes, although there remains a lack of knowledge regarding the underlying epigenomics of PDAC. Here we perform multi-parametric integrative analyses of chromatin immunoprecipitation-sequencing (ChIP-seq) on multiple histone modifications, RNA-sequencing (RNA-seq), and DNA methylation to define epigenomic landscapes for PDAC subtypes, which can predict their relative aggressiveness and survival...
May 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/29600794/fluid-collection-after-partial-pancreatectomy-eus-drainage-and-long-term-follow-up
#2
Fabrice Caillol, Sebastien Godat, Olivier Turrini, Christophe Zemmour, Erwan Bories, Christian Pesenti, Jean Phillippe Ratone, Jacques Ewald, Jean Robert Delpero, Marc Giovannini
Background and Objectives: Postoperative fluid collection due to pancreatic leak is the most frequent complication after pancreatic surgery. Endoscopic ultrasound (EUS)-guided drainage of post-pancreatic surgery fluid collection is the gold standard procedure; however, data on outcomes of this procedure are limited. The primary endpoint of our study was relapse over longterm followup, and the secondary endpoint was the efficiency and safety of EUS-guided drainage of post-pancreatic surgery fluid collection...
March 29, 2018: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/29519329/endoscopic-ultrasound-guided-drainage-of-pancreatic-fluid-collections
#3
REVIEW
Marc Giovannini
Ultrasound-guided drainage is the first-line modality for drainage of symptomatic of pancreatic fluid collections. In the context of pancreatic cancer, use of multiple double-pigtail plastic stents suffice, with high treatment efficacy. This approach provides similar success rates with low complications and better quality of life compared with surgery. Lumen apposing metallic stents (LAMSs) permit more effective drainage with larger diameter; because of their higher costs than plastic stents, their main role is probably in the context of walled-off necrosis, but the place and the use of LAMS should be studied to avoid and reduce the risks of complications...
April 2018: Gastrointestinal Endoscopy Clinics of North America
https://www.readbyqxmd.com/read/29251271/can-endoscopic-ultrasound-guided-needle-based-confocal-laser-endomicroscopy-replace-fine-needle-aspiration-for-pancreatic-and-mediastinal-diseases
#4
REVIEW
Jintao Guo, Manoop S Bhutani, Marc Giovannini, Zhaoshen Li, Zhendong Jin, Aiming Yang, Guoqiang Xu, Guiqi Wang, Siyu Sun
New applications of confocal laser endomicroscopy (CLE) have been developed, such as needle-based CLE (nCLE) for pancreatic masses, pancreatic cystic tumors, and lymph nodes. nCLE is feasible during endoscopic ultrasound (EUS) examination, and preliminary results are very encouraging and suggest this technology may be used in future as a useful adjunct in cases of inconclusive EUS-guided fine-needle aspiration. The aim of this paper is to give an update in this new technology and to define its place in the diagnosis of pancreatic masses and mediastinal diseases...
November 2017: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/29251270/practice-guidelines-for-endoscopic-ultrasound-guided-celiac-plexus-neurolysis
#5
Jonathan M Wyse, Robert Battat, Siyu Sun, Adrian Saftoiu, Ali A Siddiqui, Ang Tiing Leong, Brenda Lucia Arturo Arias, Carlo Fabbri, Douglas G Adler, Erwin Santo, Evangelos Kalaitzakis, Everson Artifon, Girish Mishra, Hussein Hassan Okasha, Jan Werner Poley, Jintao Guo, Juan J Vila, Linda S Lee, Malay Sharma, Manoop S Bhutani, Marc Giovannini, Masayuki Kitano, Mohamad Ali Eloubeidi, Mouen A Khashab, Nam Q Nguyen, Payal Saxena, Peter Vilmann, Pietro Fusaroli, Pramod Kumar Garg, Sammy Ho, Shuntaro Mukai, Silvia Carrara, Subbaramiah Sridhar, Sundeep Lakhtakia, Surinder S Rana, Vinay Dhir, Anand V Sahai
OBJECTIVES: The objective of guideline was to provide clear and relevant consensus statements to form a practical guideline for clinicians on the indications, optimal technique, safety and efficacy of endoscopic ultrasound guided celiac plexus neurolysis (EUS-CPN). METHODS: Six important clinical questions were determined regarding EUS-CPN. Following a detailed literature review, 6 statements were proposed attempting to answer those questions. A group of expert endosonographers convened in Chicago, United States (May 2016), where the statements were presented and feedback provided...
November 2017: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/29250586/endoscopic-ultrasound-guided-placement-of-plastic-pigtail-stents-for-the-drainage-of-refractory-malignant-ascites
#6
Rafael Romero-Castro, Victoria Alejandra Jimenez-Garcia, Jaime Boceta-Osuna, Luis Castilla-Guerra, Francisco Pellicer-Bautista, Angel Caunedo-Alvarez, Juan Manuel Herrerias-Gutierrez, Manuel Romero-Gómez, Marc Giovannini
Endoscopic ultrasound (EUS)-guided drainage is now the treatment of choice in cases of pancreatic pseudocysts and walled-off necrosis, especially in the absence of luminal bulging and in patients with portal hypertension. Malignant refractory ascites usually heralds a poor prognosis and substantially impairs the quality of life of patients because of the symptoms experienced and the need for repeated paracentesis. EUS-guided placement of lumen-apposing, fully covered, self-expandable metal stents (FCSEMS) has been reported for the drainage of malignant ascites...
November 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29186684/pancreatic-adenocarcinoma-therapeutic-targets-revealed-by-tumor-stroma-cross-talk-analyses-in-patient-derived-xenografts
#7
Rémy Nicolle, Yuna Blum, Laetitia Marisa, Celine Loncle, Odile Gayet, Vincent Moutardier, Olivier Turrini, Marc Giovannini, Benjamin Bian, Martin Bigonnet, Marion Rubis, Nabila Elarouci, Lucile Armenoult, Mira Ayadi, Pauline Duconseil, Mohamed Gasmi, Mehdi Ouaissi, Aurélie Maignan, Gwen Lomberk, Jean-Marie Boher, Jacques Ewald, Erwan Bories, Jonathan Garnier, Anthony Goncalves, Flora Poizat, Jean-Luc Raoul, Veronique Secq, Stephane Garcia, Philippe Grandval, Marine Barraud-Blanc, Emmanuelle Norguet, Marine Gilabert, Jean-Robert Delpero, Julie Roques, Ezequiel Calvo, Fabienne Guillaumond, Sophie Vasseur, Raul Urrutia, Aurélien de Reyniès, Nelson Dusetti, Juan Iovanna
Preclinical models based on patient-derived xenografts have remarkable specificity in distinguishing transformed human tumor cells from non-transformed murine stromal cells computationally. We obtained 29 pancreatic ductal adenocarcinoma (PDAC) xenografts from either resectable or non-resectable patients (surgery and endoscopic ultrasound-guided fine-needle aspirate, respectively). Extensive multiomic profiling revealed two subtypes with distinct clinical outcomes. These subtypes uncovered specific alterations in DNA methylation and transcription as well as in signaling pathways involved in tumor-stromal cross-talk...
November 28, 2017: Cell Reports
https://www.readbyqxmd.com/read/29063871/a-multi-institutional-consensus-on-how-to-perform-endoscopic-ultrasound-guided-peri-pancreatic-fluid-collection-drainage-and-endoscopic-necrosectomy
#8
Jintao Guo, Adrian Saftoiu, Peter Vilmann, Pietro Fusaroli, Marc Giovannini, Girish Mishra, Surinder S Rana, Sammy Ho, Jan-Werner Poley, Tiing Leong Ang, Evangelos Kalaitzakis, Ali A Siddiqui, Jose G De La Mora-Levy, Sundeep Lakhtakia, Manoop S Bhutani, Malay Sharma, Shuntaro Mukai, Pramod Kumar Garg, Linda S Lee, Juan J Vila, Everson Artifon, Douglas G Adler, Siyu Sun
There is a lack of consensus on how endoscopic ultrasound (EUS)-guided pseudocyst drainage and endoscopic necrosectomy should be performed. This survey was carried out amongst members of the EUS Journal Editorial Board to describe their practices in performing this procedure. This was a worldwide multi-institutional survey amongst members of the EUS Journal Editorial Board in May 2017. The responses to a 22-question survey with respect to the practice of EUS-guided pseudocyst drainage and endoscopic necrosectomy were obtained...
September 2017: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/29063870/endoscopic-ultrasound-guided-pancreatic-duct-drainage-ready-for-the-prime-time
#9
EDITORIAL
Marc Giovannini
No abstract text is available yet for this article.
September 2017: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/29054396/clinical-outcome-after-biliary-drainage-for-metastatic-colorectal-cancer-survival-analysis-and-prognostic-factors
#10
Floriane Sellier, Erwan Bories, Camille Sibertin-Blanc, Karolina Griffiths, Laetitia Dahan, Marc Giovannini, Jean Gaudart, Jean-Franois Seitz, Rene Laugier, Fabrice Caillol, Philippe Grandval
INTRODUCTION: Biliary obstruction secondary to colorectal cancer liver metastases is associated with a poor prognosis especially when chemotherapy cannot be re-started. The aim of this study was to determine the survival after biliary drainage and the associated prognostic factors. METHODS: Patients from two French centers were included retrospectively after first biliary endoscopic retrograde cholangiopancreatography or percutaneous transhepatic cholangiography drainage for biliary obstruction secondary to liver metastases of colorectal cancer, occurring during chemotherapy...
February 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29026599/comparison-of-pancreatic-histology-specimens-obtained-by-eus-19g-versus-22g-core-biopsy-needles-a-prospective-multicentre-study-among-experienced-pathologists
#11
Maria Chiara Petrone, Jan-Werner Poley, Matteo Bonzini, Ihab Abdulkader, Katharina Biermann, Genevieve Monges, Guido Rindi, Claudio Doglioni, Marco J Bruno, Marc Giovannini, Julio Iglesias-Garcia, Alberto Larghi, Paolo Giorgio Arcidiacono
BACKGROUND AND AIM: Scanty data about inter-observer agreement (IOA) among pathologists in the evaluation of pancreatic samples acquired with EUS histology needle are available. The aim of this study was to determine IOA on adequacy of pancreatic histology specimens obtained with a 22G needle by a panel of experienced pathologist, in comparison with the 19G needle. METHODS: This multicentre prospective study involved 73 pancreatic specimens prepared using histology needles of different calibres...
October 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28845106/impact-of-full-spectrum-endoscopy%C3%A2-fuse%C3%A2-endochoice%C3%A2-on-adenoma-detection-a-prospective-french-pilot-study
#12
Jean-Philippe Ratone, Erwan Bories, Fabrice Caillol, Christian Pesenti, Sébastien Godat, Floriane Sellier, Solene Hoibian, Marine Landon, Cécilia Servajean, Chiara De Cassan, Valentin Lestelle, Jean-Patrick Casanova, Flora Poizat, Marc Giovannini
BACKGROUND: Currently, colonoscopy and polypectomy are the gold standard methods for the prevention of incident cases of colorectal cancer. The use of a new colonoscope (Fuse(®), EndoChoice(®)) with a larger view of up to 330° appears to improve the adenoma detection rate (ADR). We performed a prospective observational study concerning this scope. The primary endpoint was potentially omitted adenomas (POA), i.e. adenomas seen on the side screens that will not appear on the central display during colonoscopy withdrawal without oriented movements...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/28739291/pancreatic-cancer-screening-still-a-delusion
#13
REVIEW
Pedro Moutinho-Ribeiro, Rosa Coelho, Marc Giovannini, Guilherme Macedo
Pancreatic adenocarcinoma represents the fourth most common cause of cancer mortality and death due to pancreatic cancer (PC) have increased since 2003. Its incidence has also raised about 30% in the past decade and it is expected to become the second cause of cancer mortality by 2020 in the USA. Most PC present with metastatic disease and improvements in treatment outcomes for this group have been disappointing. These observations support the idea that screening to identify patients at an earlier stage might be an important strategy in improving overall PC outcomes...
September 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28685745/use-of-partially-covered-and-uncovered-metallic-prosthesis-for-endoscopic-ultrasound-guided-hepaticogastrostomy-results-of-a-retrospective-monocentric-study
#14
Chiara De Cassan, Erwan Bories, Christian Pesenti, Fabrice Caillol, Sébastien Godat, Jean Philippe Ratone, Jean Robert Delpero, Jacques Ewald, Marc Giovannini
BACKGROUND AND OBJECTIVES: Endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) represents an option to treat obstructive jaundice when endoscopic retrograde cholangiopancreatography (ERCP) fails. The success rate of this procedure has been shown to be very high. Up to now, plastic and self-expandable metallic stents (SEMSs) have been employed, each of them presenting some limitations. The aims of this study were to evaluate the technical and functional success rates of EUS-HGS using a dedicated biliary SEMS with a half-covered part (Giobor® stent)...
September 2017: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/28621295/efficacy-and-safety-in-case-of-technical-success-of-endoscopic-ultrasound-guided-transhepatic-antegrade-biliary-drainage-a-report-of-a-monocentric-study
#15
Sébastien Godat, Erwan Bories, Fabrice Caillol, Christian Pesenti, Jean Philippe Ratone, Chiara de Cassan, Marc Giovannini
BACKGROUND AND OBJECTIVES: Endoscopic ultrasound (EUS)-guided biliary drainage techniques are alternative procedures in cases of obstructive jaundice with altered anatomy or failed ERCP. Complications related to EUS-guided antegrade drainage (EUS-AD) are still present in up to 10% of cases, and combination of procedures is sometimes suggested to avoid adverse events. The purpose of our study is to evaluate the efficacy and safety of EUS-AD with transhepatic access in case of technical success...
May 2017: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/28610622/very-late-onset-cytomegalovirus-disease-a-case-report-and-review-of-the-literature
#16
REVIEW
Hania Burgan, Gael Gosteli, Marc Giovannini, Reto Lienhard, Olivier Clerc
BACKGROUND: Cytomegalovirus (CMV) infection remains one of the most common and feared complications of transplantation, justifying prophylaxis or preemptive strategies guided by donor and recipient CMV serostatus. In case of seronegative donor and recipient (D-/R-), no prophylaxis is recommended. Late-onset CMV disease is usually defined as occurring after prophylaxis discontinuation in D+/R- transplant patients. CASE PRESENTATION: We are reporting the case of a D-/R- kidney Caucasian transplant recipient presenting with CMV primoinfection 12 years after renal transplant, and discuss the role of a secondary prophylaxis so late after transplantation...
June 13, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28469359/probe-confocal-laser-endomicroscopy-in-the-therapeutic-endoscopic-management-of-barrett-s-dysplasia
#17
Fabrice Caillol, Sebastien Godat, Flora Poizat, Aurélie Auttret, Christian Pesenti, Erwan Bories, Jean Phillipe Ratone, Marc Giovannini
BACKGROUND: Endoscopic management of Barrett's esophagus (BE) depends on the histological stage of BE and includes the following: follow up, endotherapy with thermal ablation, and piecemeal or monobloc endoscopic resection (ER). We know that biopsies are unreliable in 20-75% of cases. The aim of our study was to evaluate the efficiency of probe confocal laser endomicroscopy (pCLE) in the diagnosis of the histological stage of BE, compared with the final histological results after ER. METHODS: This retrospective study was based on a prospective registry of patients referred for management of BE-associated dysplasia...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/28456389/development-of-reliable-and-validated-tools-to-evaluate-technical-resuscitation-skills-in-a-pediatric-simulation-setting-resuscitation-and-emergency-simulation-checklist-for-assessment-in-pediatrics
#18
Camille Faudeux, Antoine Tran, Audrey Dupont, Jonathan Desmontils, Isabelle Montaudié, Jean Bréaud, Marc Braun, Jean-Paul Fournier, Etienne Bérard, Noémie Berlengi, Cyril Schweitzer, Hervé Haas, Hervé Caci, Amélie Gatin, Lisa Giovannini-Chami
OBJECTIVES: To develop a reliable and validated tool to evaluate technical resuscitation skills in a pediatric simulation setting. STUDY DESIGN: Four Resuscitation and Emergency Simulation Checklist for Assessment in Pediatrics (RESCAPE) evaluation tools were created, following international guidelines: intraosseous needle insertion, bag mask ventilation, endotracheal intubation, and cardiac massage. We applied a modified Delphi methodology evaluation to binary rating items...
September 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28275007/gene-expression-profiling-of-patient-derived-pancreatic-cancer-xenografts-predicts-sensitivity-to-the-bet-bromodomain-inhibitor-jq1-implications-for-individualized-medicine-efforts
#19
Benjamin Bian, Martin Bigonnet, Odile Gayet, Celine Loncle, Aurélie Maignan, Marine Gilabert, Vincent Moutardier, Stephane Garcia, Olivier Turrini, Jean-Robert Delpero, Marc Giovannini, Philippe Grandval, Mohamed Gasmi, Mehdi Ouaissi, Veronique Secq, Flora Poizat, Rémy Nicolle, Yuna Blum, Laetitia Marisa, Marion Rubis, Jean-Luc Raoul, James E Bradner, Jun Qi, Gwen Lomberk, Raul Urrutia, Andres Saul, Nelson Dusetti, Juan Iovanna
c-MYC controls more than 15% of genes responsible for proliferation, differentiation, and cellular metabolism in pancreatic as well as other cancers making this transcription factor a prime target for treating patients. The transcriptome of 55 patient-derived xenografts show that 30% of them share an exacerbated expression profile of MYC transcriptional targets (MYC-high). This cohort is characterized by a high level of Ki67 staining, a lower differentiation state, and a shorter survival time compared to the MYC-low subgroup...
April 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28196390/long-term-outcome-of-endoscopic-ultrasound-guided-pelvic-abscess-drainage-a-two-center-series
#20
MULTICENTER STUDY
Laurent Poincloux, Fabrice Caillol, Christophe Allimant, Erwan Bories, Christian Pesenti, Aurélien Mulliez, Frederic Faure, Olivier Rouquette, Michel Dapoigny, Armando Abergel, Marc Giovannini
Background and study aim  Endoscopic ultrasound (EUS)-guided pelvic abscess drainage has been reported but long-term data remain limited. This two-center study evaluated long-term outcome of EUS-guided pelvic abscess drainage. Patients and methods  Between May 2003 and December 2015, 37 consecutive patients were treated for perirectal or perisigmoid abscesses via EUS-guided drainage using plastic or lumen-apposing metal stent (LAMS). Clinical success was defined as complete resolution of the abscess on follow-up computed tomography (CT) scan at 4 weeks with symptom relief...
May 2017: Endoscopy
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