keyword
MENU ▼
Read by QxMD icon Read
search

Biphosphonates

keyword
https://www.readbyqxmd.com/read/27895021/1-in-vitro-and-in-vivo-activity-of-sulfur-containing-linear-bisphosphonates-against-apicomplexan-parasites
#1
Sergio H Szajnman, Tamila Galaka, Zhu-Hong Li, Catherine Li, Nathan M Howell, María N Chao, Boris Striepen, Vasant Muralidharan, Silvia N J Moreno, Juan B Rodriguez
We tested a series of sulfur-containing linear bisphosphonates against Toxoplasma gondii, the etiologic agent of toxoplasmosis. The most potent compound ( 22: , 1-[(n-decylsulfonyl)ethyl]-1,1-biphosphonic acid) is a sulfone-containing compound, which had an EC50 of 0.11 ± 0.02 μM against intracellular tachyzoites. The compound showed low toxicity when tested in tissue culture with a selectivity index of >2,000. 22: also showed high activity in vivo in a toxoplasmosis mouse model. The compound inhibited the Toxoplasma farnesyl diphosphate synthase (TgFPPS) but the concentration needed to inhibit 50% of the enzymatic activity (IC50) was higher than the concentration that inhibited 50% of growth...
November 28, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27640992/process-quality-indicators-for-chronic-kidney-disease-risk-management-a-systematic-literature-review
#2
Kirsten P J Smits, Grigory Sidorenkov, Henk J G Bilo, Margriet Bouma, Gerjan J Navis, Petra Denig
BACKGROUND AND OBJECTIVES: Quality indicators (QIs) can be used for measuring the quality of actions of healthcare providers. This systematic review gives an overview of such QIs measuring processes of care for chronic kidney disease (CKD), and identifies the QIs that have content, face, operational and/or predictive validity. METHODS: PubMed and Embase were searched using a strategy combining the terms "quality of care," "quality indicators" and "chronic kidney disease"...
October 2016: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/27299924/how-do-i-manage-a-patient-with-biphosphonate-related-osteonecrosis-of-the-jaw-bronj
#3
Ajit Auluck
No abstract text is available yet for this article.
May 2016: Journal—Canadian Dental Association, Journal de L'Association Dentaire Canadienne
https://www.readbyqxmd.com/read/27284762/case-report-of-early-aseptic-loosening-of-total-hip-arthroplasty-in-monostotic-paget-disease-a-diagnostic-challenge
#4
Diana Crego-Vita, Daniel Aedo-Martín, Coral Sánchez-Pérez
Paget's disease of bone is a localised chronic osteopathy which produces bone deformities, bone hypervascularity, structural weakness and altered joint biomechanics. Although radiological diagnosis of Paget's disease of bone is usually straightforward, monostotic cases may potentially raise specific problems which require invasive and expensive procedures such as bone biopsies. The pelvis and upper femur are frequently affected, resulting in disabling hip disease that may require total hip arthroplasty. We report a case of Paget disease of bone in an 84-year-old woman, which was initially identified as avascular necrosis of the hip, reason for which she underwent total hip arthroplasty...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27223431/zoledronic-acid-impairs-stromal-reactivity-by-inhibiting-m2-macrophages-polarization-and-prostate-cancer-associated-fibroblasts
#5
Giuseppina Comito, Coral Pons Segura, Maria Letizia Taddei, Michele Lanciotti, Sergio Serni, Andrea Morandi, Paola Chiarugi, Elisa Giannoni
Zoledronic acid (ZA) is a biphosphonate used for osteoporosis treatment and also proved to be effective to reduce the pain induced by bone metastases when used as adjuvant therapy in solid cancers. However, it has been recently proposed that ZA could have direct anti-tumour effects, although the molecular mechanism is unknown. We herein unravel a novel anti-tumour activity of ZA in prostate cancer (PCa), by targeting the pro-tumorigenic properties of both stromal and immune cells. Particularly, we demonstrate that ZA impairs PCa-induced M2-macrophages polarization, reducing their pro-invasive effect on tumour cells and their pro-angiogenic features...
May 20, 2016: Oncotarget
https://www.readbyqxmd.com/read/27141048/osteoporotic-spinal-burst-fracture-in-a-young-adult-as-first-presentation-of-systemic-mastocytosis
#6
Christina Ble, Parmenion P Tsitsopoulos, Dimitrios M Anestis, Sofia Hadjileontiadou, Triantafyllia Koletsa, Maria Papaioannou, Christos Tsonidis
Osteoporotic vertebral fractures are uncommon in young adults and usually indicate an underlying disease. Systemic mastocytosis is a myeloproliferative neoplasm, which can be associated with osteoporosis. A previously healthy 30-year-old man presented with an L4 burst fracture after lifting a heavy object. He was operated with laminectomy and posterior lumbar instrumentation. During surgery, abnormally soft bone was noted. Postoperatively, osteoporosis was confirmed with measurement of bone mineral density...
2016: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/27117306/-male-osteoporosis
#7
P Farahmand, R Spiegel, J D Ringe
BACKGROUND: Osteoporosis in men is an important public health problem with more than 1 million cases in Germany. Although osteoporotic fractures have a much higher mortality in men than in women, male patients are still underdiagnosed and undertreated. OBJECTIVE: Epidemiology of male osteoporosis and current treatment situation, pathophysiological aspects at the hormonal level, risk factors, diagnostic work-up and therapeutic options. MATERIAL AND METHODS: Overview of data concerning male osteoporosis, recommendations for diagnostic work-up and presentation of the study situation on pharmaceutical therapies...
June 2016: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/26843726/osteonecrosis-of-the-jaw-after-bisphosphonates-treatment-in-patients-with-multiple-myeloma
#8
Svetlana Krstevska, Sonja Genadieva Stavric, Lidija Cevrevska, Borce Georgjievski, Oliver Karanfilski, Tatjana Sotirova, Trajan Balkanov
BACKGROUND: Bone lytic lesion in Multiple myeloma are the most commonly presented symptoms which require treatment with bisphosphonates (BPs). BPs are providing supportive care, reducing the rate of skeletal morbidity but evidently not abolishing it, the criteria for stopping their administration have to be different from those used for classic antineoplastic drugs, and they should not be stopped when metastatic bone disease is progressing. Osteonecrosis of the jaw (ONJ) has been associated recently with the use of BPs...
December 2015: Medical Archives
https://www.readbyqxmd.com/read/26690845/natural-history-of-non-small-cell-lung-cancer-with-bone-metastases
#9
Daniele Santini, Santini Daniele, Sandro Barni, Barni Sandro, Salvatore Intagliata, Intagliata Salvatore, Alfredo Falcone, Falcone Alfredo, Francesco Ferraù, Ferraù Francesco, Domenico Galetta, Galetta Domenico, Luca Moscetti, Moscetti Luca, Nicla La Verde, La Verde Nicla, Toni Ibrahim, Ibrahim Toni, Fausto Petrelli, Petrelli Fausto, Enrico Vasile, Vasile Enrico, Laura Ginocchi, Ginocchi Laura, Davide Ottaviani, Ottaviani Davide, Flavia Longo, Longo Flavia, Cinzia Ortega, Ortega Cinzia, Antonio Russo, Russo Antonio, Giuseppe Badalamenti, Badalamenti Giuseppe, Elena Collovà, Collovà Elena, Gaetano Lanzetta, Lanzetta Gaetano, Giovanni Mansueto, Mansueto Giovanni, Vincenzo Adamo, Adamo Vincenzo, Filippo De Marinis, De Marinis Filippo, Maria Antonietta Satolli, Flavia Cantile, Cantile Flavia, Andrea Mancuso, Mancuso Andrea, Francesca Maria Tanca, Raffaele Addeo, Addeo Raffaele, Marco Russano, Russano Marco, Michelle Sterpi, M Sterpi, Francesco Pantano, Pantano Francesco, Bruno Vincenzi, Vincenzi Bruno, Giuseppe Tonini, Tonini Giuseppe
We conducted a large, multicenter, retrospective survey aimed to explore the impact of tumor bone involvement in Non-Small Cell Lung Cancer.Data on clinical-pathology, skeletal outcomes and bone-directed therapies for 661 deceased patients with evidence of bone metastasis were collected and statistically analyzed. Bone metastases were evident at diagnosis in 57.5% of patients. In the remaining cases median time to bone metastases appearance was 9 months. Biphosphonates were administered in 59.6% of patients...
2015: Scientific Reports
https://www.readbyqxmd.com/read/26587372/osteonecrosis-of-the-jaw-during-biyearly-treatment-with-zoledronic-acid-for-aromatase-inhibitor-associated-bone-loss-in-early-breast-cancer-a-literature-review
#10
REVIEW
Hampig Raphael Kourie, Joelle Antoun, Elie El Rassy, Marc Rassy, Claude Sader-Ghorra, Joseph Kattan
Osteonecrosis of the jaw (ONJ) is one of the most relevant and specific complication of biphosphonates. ONJ in patients receiving zoledronic acid every 3 to 4 weeks is frequently described, but the ONJ biyearly regimen used to reduce aromatase inhibitor associated bone loss (AIBL), is rarely reported. A literature review, focusing on the important trials using zoledronic acid to reduce AIBL, found that the mean risk of developing ONJ when zoledronic acid is used biyearly varies between 0.12% and 0.7%.
September 2015: Journal of Bone Oncology
https://www.readbyqxmd.com/read/26406544/a-rare-avascolar-osteonecrosis-of-the-knee-related-to-biphosphonate-treatment-in-a-patient-with-metastatic-breast-cancer
#11
Lorenzo Rossi, Simona Di Lascio, Michail Kouros, Olivia Pagani
Bisphosphonates are widely used both in the multidisciplinary management of bone metastases, especially osteolytic lesions from solid tumors or multiple myeloma, and of osteoporosis.Aseptic osteonecrosis, especially of the jaw, is among the well-known, although uncommon, side effects of bisphosphonates. Osteonecrosis of other bones has been very rarely reported with the use of bisphosphonates.We describe a rare case of osteonecrosis of the distal femur associated with the use of bisphosphonates in a 74 years old female patient with metastatic breast cancer...
2015: Breast Disease
https://www.readbyqxmd.com/read/26171047/effect-of-the-cumulative-dose-of-zoledronic-acid-on-the-pathogenesis-of-osteonecrosis-of-the-jaws
#12
Meral Günaldi, Cigdem Usul Afsar, Berna Bozkurt Duman, Ismail Oguz Kara, Ufuk Tatli, Berksoy Sahin
Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a severe bone disease for which the pathogenetic mechanisms and risk factors are not fully understood. The present study evaluated the data of 652 patients with bone metastasis that had undergone treatment with biphosphonates. Subsequently, 24 patients with BRONJ and 20 control patients without BRONJ that were treated with zoledronic acid were enrolled. It was found that BRONJ occurred in 3.6% of patients. The mean age and the administration of dental treatment were found to be significantly associated with BRONJ development (P=0...
July 2015: Oncology Letters
https://www.readbyqxmd.com/read/26065286/-calcific-uremic-arteriolopathy-clinical-features-and-treatment
#13
Boris Kudumija, Mladen Knotek, Drasko Pavlović, Sonja Dits
Calcific uremic arteriolopathy or alciphylaxis is a malignant form of calcification of small arteries and arterioles, usually present in patients with chronic kidney disease and dialysis therapy. It causes high mortality. Histological distinctive feature are calcium deposits lining vascular intima. Calcification of medial muscle layer, inflammation and necrosis of subcutaneous adipose tissue are frequent. The disease begins with painful violaceous mottling, resembling livedo reticularis. Ths skin lesion progresses to ulcers and eschars, sometimes it becomes very vulnerable to secondary infection which can often develop into fatal sepsis...
March 2015: Lijec̆nic̆ki Vjesnik
https://www.readbyqxmd.com/read/26024926/comparison-of-polyethylene-glycol-vs-sodium-picosulphate-vs-sodium-biphosphonate-by-efficacy-in-bowel-cleansing-and-patients-tolerability-a-randomised-trial
#14
Z Heetun, R Crowley, F Zeb, D Kearns, M H Brennan, C O'Connor, G Courtney, A R Aftab
INTRODUCTION: Adequate bowel preparation is necessary for a complete colonoscopy. Polyethylene glycol-electrolyte oral solution (PEG-EOS), sodium picosulphate (SS) and sodium biphosphonate (SP) are the three most commonly used purgative agents. We aimed to determine their efficacy and tolerability compared to each other in a randomised study. METHODS: 313 patients were randomly assigned to receive either PEG-EOS, SS or SP. Patients completed a tolerability score pre-colonoscopy...
August 2016: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/26019741/bone-changes-in-alcoholic-liver-disease
#15
REVIEW
Emilio González-Reimers, Geraldine Quintero-Platt, Eva Rodríguez-Rodríguez, Antonio Martínez-Riera, Julio Alvisa-Negrín, Francisco Santolaria-Fernández
Alcoholism has been associated with growth impairment, osteomalacia, delayed fracture healing, and aseptic necrosis (primarily necrosis of the femoral head), but the main alterations observed in the bones of alcoholic patients are osteoporosis and an increased risk of fractures. Decreased bone mass is a hallmark of osteoporosis, and it may be due either to decreased bone synthesis and/or to increased bone breakdown. Ethanol may affect both mechanisms. It is generally accepted that ethanol decreases bone synthesis, and most authors have reported decreased osteocalcin levels (a "marker" of bone synthesis), but some controversy exists regarding the effect of alcohol on bone breakdown, and, indeed, disparate results have been reported for telopeptide and other biochemical markers of bone resorption...
May 28, 2015: World Journal of Hepatology
https://www.readbyqxmd.com/read/25922119/derivation-and-validation-of-a-clinical-diagnostic-tool-for-the-identification-of-older-community-dwellers-with-hypovitaminosis-d
#16
Cedric Annweiler, Anastasiia Kabeshova, Mathilde Legeay, Bruno Fantino, Olivier Beauchet
OBJECTIVES: Hypovitaminosis D is highly prevalent among seniors. Although evidence is insufficient to recommend routine vitamin D screening in seniors, universal vitamin D supplementation is not desirable either. To rationalize vitamin D determination, our objective was to elaborate and test a clinical diagnostic tool for the identification of seniors with hypovitaminosis D without using a blood test. DESIGN: Derivation of a clinical diagnostic tool using artificial neural networks (multilayer perceptron; MLP) in randomized training subgroup of Prévention des Chutes, Réseau 4' cohort, and validation in randomized testing subgroup...
June 1, 2015: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/25823488/treatment-considerations-in-hutchinson-gilford-progeria-syndrome-a-case-report
#17
H Hazan-Molina, D Aizenbud, Aizenbud D Dror
Hutchinson-Guilford progeria syndrome is an extremely rare condition classified as one of the premature ageing syndromes. This case presents a 16-year-old Israeli female patient, suffering from a variant of Hutchinson-Guilford progeria with a history of treatment with oral biphosphnates. The patient presented with typical cranial and facial features of the syndrome including delayed teeth eruption and root development probably due to insufficient jaw growth and severs retrognatic position of the maxilla and mandible...
2015: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/25709149/technical-refinements-in-mandibular-reconstruction-with-free-fibula-flaps-outcome-oriented-retrospective-review-of-99-cases
#18
REVIEW
G Colletti, L Autelitano, D Rabbiosi, F Biglioli, M Chiapasco, M Mandalà, F Allevi
Congenital disease, major trauma, tumour resection and biphosphonate-related osteonecrosis can lead to partial, subtotal, or total loss of the mandibular bone. Minor defects can be easily reconstructed using bone grafts, whereas microvascular free tissue transfer may be unavoidable in the case of major bone loss or poor quality of soft tissue. Simple bone or composite osteocutaneous fibula free flaps have proven invaluable and remain the workhorse for microvascular mandibular reconstruction in daily practice...
October 2014: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/25674321/oral-bisphosphonate-associated-osteonecrosis-of-maxillary-bone-a-review-of-18-cases
#19
Edgardo López-D'alessandro, Fabiana Mardenlli, Marisa Paz
Biphosphonate-associated maxillary bone osteonecrosis (BPMO) is a complication related to nitrogen-containing biphosphonate therapy. This adverse effect occasionally appears in patients who are administered biphosphonates through intravenous infusion for the treatment of cancer involving bone metastases. It can also present, in a lesser degree, in patients who take these drugs orally for the treatment of osteoporosis. Lately, there has been an increase in the number of cases of osteopenia and osteoporosis due to the increasing life expectancy of the world's population...
December 2014: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/25496793/-impact-of-lung-cancer-treatments-on-renal-function
#20
REVIEW
A-C Toffart, S Belaiche, D Moro-Sibilot, S Couraud, L Sakhri
INTRODUCTION: Renal failure in patients with lung cancer may be multifactorial: related to the patients and their comorbidities, direct tumor compression or the toxicity of cancer treatments and other associated medications. This literature review is intended to describe the state of knowledge regarding the nephrotoxicity of treatments used in thoracic oncology. FINDINGS: The majority of chemotherapy treatments are potentially nephrotoxic. Cisplatin and pemetrexed exhibit mainly renal tubular toxicity, while vascular renal impairment is found with gemcitabine and bevacizumab...
December 2014: Revue des Maladies Respiratoires
keyword
keyword
97613
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"