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Evelyn Rivera-Toledo, Iván Salido-Guadarrama, Mauricio Rodríguez-Dorantes, Laura Torres-González, Carlos Santiago-Olivares, Beatriz Gómez
Cells susceptible to persistent viral infections undergo important changes in their biological functions as a consequence of the expression of viral gene products that are capable of altering the gene expression profile of the host cell. Previously, we reported that persistence of the RSV genome in a mouse macrophage cell line induces important alterations in cell homeostasis, including constitutive expression of IFN-β and other pro-inflammatory cytokines. Here, we postulated that changes in the homeostasis of non-infected macrophages could be induced by soluble factors secreted by persistently RSV- infected macrophages...
January 6, 2017: Virus Research
H Carrillo-Navas, A Y Guadarrama-Lezama, E J Vernon-Carter, S García-Díaz, I Reyes, J Alvarez-Ramírez
This work considered gelatinized wheat flour fraction with properties similar to hydrocolloid to enhance the strength of dough network by improving water retention and rheological characteristics. The gelatinized (90 °C) fraction of the wheat flour was incorporated in the dough formulation at different levels (5, 10, and 20% w/w). The effects of the gelatinized flour (GF) fraction on the dough rheology and thermal properties were studied. The incorporation of GF induced a moderate increase of dough viscoelasticity and reduced the freezing and melting enthalpies...
November 2016: Journal of Food Science and Technology
Irene Gil-Sánchez, Begoña Ayuda-Durán, Susana González-Manzano, Celestino Santos-Buelga, Carolina Cueva, M Angeles Martín-Cabrejas, Marisa Sanz-Buenhombre, Alberto Guadarrama, M Victoria Moreno-Arribas, Begoña Bartolomé
BACKGROUND: Currently, there is growing interest in extracts derived from winery by-products due to their beneficial health properties, which are associated to the presence of bioactive compounds. In this paper, we have carried out the chemical characterization and in vitro colonic fermentation of four grape pomace (GP) extracts rich in polyphenols and dietary fibre. RESULT: Firstly, phenolic and dietary fibre composition of the GP extracts was determined. The highest individual phenolic concentrations corresponded to gallic and ellagic acids, followed by catechins and flavonols...
December 27, 2016: Journal of the Science of Food and Agriculture
Norma Velázquez-Guadarrama, Alma L Olivares-Cervantes, Eva Salinas, Leticia Martínez, Magdalena Escorcia, Ricardo Oropeza, Irma Rosas
Coagulase-positive staphylococci (CoPS) are opportunistic pathogens carrying various mechanisms of resistance that have a large number of virulence factors, and whose ability to induce illness is associated with the host. This study aimed to investigate the presence of environmental coagulase-positive staphylococci, their susceptibility profile, clonal relationship and ability to form biofilm. The 16S rRNA genes from CoPS isolates were analyzed, and their antibiotic susceptibility was evaluated using the agar dilution method in accordance with Clinical and Laboratory Standards Institute guidelines...
December 22, 2016: Revista Argentina de Microbiología
José M Landeros, Fernando Belmont-Bernal, Alma Teresa Pérez-González, Mario Israel Pérez-Padrón, Patricia Guevara-Salazar, Irma Gabriela González-Herrera, Patricia Guadarrama
A novel water-soluble derivative of curcumin (Cur-[G-2]-OH) was designed and synthesized from accessible raw materials in only two steps with an overall yield of 80%. The modification of curcumin phenol groups with second-generation polyester dendrons (dendronization) as a strategy to achieve an optimal hydrophilic/hydrophobic balance allows the complete water solubilization of the new curcumin derivative (5mg/ml) at room temperature. The therapeutic potential of Cur-[G-2]-OH was investigated in terms of antioxidant capacity, intracellular uptake and cytotoxicity in both rat glioblastoma cells and normal human dermal fibroblasts...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
L Díaz Peralta, M Y Rios, A B Aguilar-Guadarrama, J J Acevedo Fernández
No abstract text is available yet for this article.
December 2016: Planta Medica
G M Avila-Villarreal, B Aguilar-Guadarrama, P Castillo-España, M E González-Trujano, C Villalobos Azucena Ibeth, S Estrada-Soto
No abstract text is available yet for this article.
December 2016: Planta Medica
G M Avila-Villarreal, D E Giles-Rivas, B Aguilar-Guadarrama, P Castillo-España, S Estrada-Soto
No abstract text is available yet for this article.
December 2016: Planta Medica
D E Giles-Rivas, B Aguilar-Guadarrama, P Castillo-España, G Ramírez-Ávila, S E Estrada-Soto
No abstract text is available yet for this article.
December 2016: Planta Medica
A A Quiroz, M Y Rios, Aba Guadarrama, Lcc Albores
No abstract text is available yet for this article.
December 2016: Planta Medica
Nieves Baenas, María Eva González-Trujano, Omar Guadarrama-Enríquez, Francisco Pellicer, Cristina García-Viguera, Diego A Moreno
BACKGROUND: Broccoli is a rich source of health-promoting glucosinolates, phenolic compounds, minerals and vitamins, which might have potential to alleviate pain. AIM: To explore the antinociceptive effects of a broccoli sprout aqueous extract (BSE) in experimental models of pain and an opioid mechanism. MATERIALS AND METHODS: the BSE was administered to mice and rats that were subjected to the writhing and formalin tests, respectively. Gastric damage or sedative-like response, as adverse effects observed in anti-inflammatory non-steroidal and opioid analgesic drugs, respectively, were also explored...
December 14, 2016: Food & Function
Sandra Mendoza-Elizalde, Nancy K Arteaga-Resendiz, Pedro Valencia-Mayoral, Raúl C Luna, Sarbelio Moreno-Espinosa, Francisco Arenas-Huertero, Gerardo Zúñiga, Norma Velázquez-Guadarrama
The bacterium Helicobacter pylori exhibits great genetic diversity, and the pathogenic roles of its virulence factors have been widely studied. However, the evolutionary dynamics of H. pylori strains during stomach colonization are not well-characterized. Here, we analyzed the microevolutionary dynamics of the toxigenic strain vacAs1m1, the non-toxigenic strain vacAs2m2, and a combination of both strains in an animal model over time. Meriones unguiculatus were inoculated with the following bacteria: group 1-toxigenic strain vacAs1m1/cagA+/cagE+/babA2+; ST181, group 2-non-toxigenic strain vacAs2m2/cagA+/cagE+/babA2+; ST2901, and group 3-both strains...
2016: Frontiers in Microbiology
S Elvira, I González-Fernández, R Alonso, J Sanz, V Bermejo-Bermejo
The Sierra de Guadarrama mountain range, located at 60 km from Madrid City (Spain), includes high valuable ecosystems following an altitude gradient, some of them protected under the Sierra de Guadarrama National Park. The characteristic Mediterranean climatic conditions and the precursors emitted from Madrid favor a high photochemical production of ozone (O3) in the region. However, very little information is available about the patterns and levels of O3 and other air pollutants in the high elevation areas and their potential effects on vegetation...
October 2016: Environmental Monitoring and Assessment
N F Santos-Sánchez, R Valadez-Blanco, B Hernández-Carlos, A Torres-Ariño, P C Guadarrama-Mendoza, R Salas-Coronado
Despite microalgae recently receiving enormous attention as a potential source of biodiesel, their use is still not feasible as an alternative to fossil fuels. Recently, interest in microalgae has focused on the production of bioactive compounds such as polyunsaturated fatty acids (PUFA), which provide microalgae a high added value. Several considerations need to be assessed for optimizing PUFA production from microalgae. Firstly, a microalgae species that produces high PUFA concentrations should be selected, such as Nannochloropsis gaditana, Isochrysis galbana, Phaeodactylum tricornutum, and Crypthecodinium cohnii, with marine species gaining more attention than do freshwater species...
October 2016: Applied Microbiology and Biotechnology
Jeff Donahue, Lisa Anne Hendricks, Marcus Rohrbach, Subhashini Venugopalan, Sergio Guadarrama, Kate Saenko, Trevor Darrell
Models based on deep convolutional networks have dominated recent image interpretation tasks; we investigate whether models which are also recurrent are effective for tasks involving sequences, visual and otherwise. We describe a class of recurrent convolutional architectures which is end-to-end trainable and suitable for large-scale visual understanding tasks, and demonstrate the value of these models for activity recognition, image captioning, and video description. In contrast to previous models which assume a fixed visual representation or perform simple temporal averaging for sequential processing, recurrent convolutional models are "doubly deep" in that they learn compositional representations in space and time...
September 1, 2016: IEEE Transactions on Pattern Analysis and Machine Intelligence
Vianney Cortés-González, Juan Carlos Zenteno, Martín Guzmán-Sánchez, Verónica Giordano-Herrera, Dalia Guadarrama-Vallejo, Narlly Ruíz-Quintero, Cristina Villanueva-Mendoza
Tietz syndrome and Waardenburg syndrome type 2A are allelic conditions caused by MITF mutations. Tietz syndrome is inherited in an autosomal dominant pattern and is characterized by congenital deafness and generalized skin, hair, and eye hypopigmentation, while Waardenburg syndrome type 2A typically includes variable degrees of sensorineural hearing loss and patches of de-pigmented skin, hair, and irides. In this paper, we report two unrelated families with MITF mutations. The first family showed an autosomal dominant pattern and variable expressivity...
September 8, 2016: American Journal of Medical Genetics. Part A
Pilar García-Tobilla, Susana R Solórzano, Iván Salido-Guadarrama, Vanessa González-Covarrubias, Gustavo Morales-Montor, Carlos E Díaz-Otañez, Mauricio Rodríguez-Dorantes
Worldwide, prostate cancer (PCa) is the second cause of death from malignant tumors among men. Establishment of aberrant epigenetic modifications, such as histone post-translational modifications (PTMs) and DNA methylation (DNAme) produce alterations of gene expression that are common in PCa. Genes of the SFRP family are tumor suppressor genes that are frequently silenced by DNA hypermethylation in many cancer types. The SFRP family is composed of 5 members (SFRP1-5) that modulate the WNT pathway, which is aberrantly activated in PCa...
November 30, 2016: Gene
D Rosales-Martinez, L Gutierrez-Xicotencatl, O Badillo-Godinez, D Lopez-Guerrero, A Santana-Calderon, R Cortez-Gomez, O Ramirez-Pliego, F Esquivel-Guadarrama
Rotavirus is the most common cause of acute infectious diarrhea in human neonates and infants. However, the studies aimed at dissecting the anti-virus immune response have been mainly performed in adults. Dendritic cells (DCs) play a crucial role in innate and acquired immune responses. Therefore, it is very important to determine the response of neonatal and infant DCs to rotavirus and to compare it to the response of adult DCs. Thus, we determined the response of monocyte-derived DCs from umbilical cord blood (UCB) and adult peripheral blood (PB) to rotavirus in vitro...
October 2016: Microbial Pathogenesis
Carlos Pineda-Vadillo, Françoise Nau, Catherin Guerin-Dubiard, Julien Jardin, Valérie Lechevalier, Marisa Sanz-Buenhombre, Alberto Guadarrama, Tamás Tóth, Éva Csavajda, Hajnalka Hingyi, Sibel Karakaya, Juhani Sibakov, Francesco Capozzi, Alessandra Bordoni, Didier Dupont
The aim of the present study was to understand to what extent the inclusion of anthocyanins into dairy and egg matrices could affect their stability after processing and their release and solubility during digestion. For this purpose, individual and total anthocyanin content of four different enriched matrices, namely custard dessert, milkshake, pancake and omelettete, was determined after their manufacturing and during in vitro digestion. Results showed that anthocyanin recovery after processing largely varied among matrices, mainly due to the treatments applied and the interactions developed with other food components...
January 1, 2017: Food Chemistry
Sibel Karakaya, Sebnem Simsek, Alper Tolga Eker, Carlos Pineda-Vadillo, Didier Dupont, Beatriz Perez, Blanca Viadel, Marisa Sanz-Buenhombre, Alberto Guadarrama Rodriguez, Zsófia Kertész, Adrienn Hegyi, Alessandra Bordoni, Sedef Nehir El
Anthocyanins, water soluble polyphenols, have been associated with several beneficial health effects. The aim of this study was to determine how the baking process and food matrix affect anthocyanin stability and bioaccessibility in bakery products in order to develop functional foods. Three well known regularly consumed bakery products (buns, breadsticks and biscuits) were enriched with anthocyanin (AC) isolated from grape skin alone or in combination with docosahexaenoic acid (AC + DHA) to reveal knowledge on AC as active ingredients in real food systems rather than pure compounds...
August 10, 2016: Food & Function
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