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Tao Guo, Xiaojun Guan, Qiaoling Zeng, Min Xuan, Quanquan Gu, Xiaojun Xu, Minming Zhang
The relationship between cerebrospinal fluid (CSF) proteins and brain function in Parkinson's disease (PD) is not explained clearly. We investigated the correlations between CSF proteins and spontaneous neuronal activity in PD patients via fractional amplitude of low-frequency fluctuation (fALFF) using the Parkinson's Progression Markers Initiative database. Twenty-eight PD patients underwent resting-state functional magnetic resonance imaging in "off" status and lumbar puncture within a month. Correlation analyses between CSF proteins and fALFF value in whole brain as well as clinical assessment scores were performed...
February 28, 2018: Neuroscience Letters
Panlong Li, Han Shan, Shengxiang Liang, Binbin Nie, Hua Liu, Shaofeng Duan, Qi Huang, Tianhao Zhang, Guanglong Dong, Yulin Guo, Jin Du, Hongkai Gao, Lin Ma, Demin Li, Baoci Shan
OBJECTIVE: Bariatric surgery could recover regional dysfunction of cerebral cortex. However, it is unknown whether bariatric surgery could recover the global-level dysfunction in subjects with obesity. The aim of this study was to investigate the effect of bariatric surgery on global-level dysfunction in subjects with obesity by resting-state functional magnetic resonance imaging (fMRI). METHODS: Resting-state fMRI was used to investigate dysfunction of whole-brain in 34 subjects with obesity and 34 age-and gender-matched normal-weight subjects, in which 17 subjects with obesity received sleeve gastrectomy...
March 2, 2018: Obesity Surgery
Song Cao, Bangyong Qin, Yi Zhang, Jie Yuan, Bao Fu, Peng Xie, Ganjun Song, Ying Li, Tian Yu
OBJECTIVE: Herpes zoster (HZ) can develop into postherpetic neuralgia (PHN), which is a chronic neuropathic pain (NP). Whether the chronification from HZ to PHN induced brain functional or structural change is unknown and no study compared the changes of the same brains of patients who transited from HZ to PHN. We minimized individual differences and observed whether the chronification of HZ to PHN induces functional and pain duration dependent grey matter volume (GMV) change in HZ-PHN patients...
2018: American Journal of Translational Research
Jan Van den Stock, Daphne Stam, François-Laurent De Winter, Dante Mantini, Benedikt Szmrecsanyi, Koen Van Laere, Rik Vandenberghe, Mathieu Vandenbulcke
Introduction: Behavioral variant frontotemporal dementia (bvFTD) is associated with abnormal emotion recognition and moral processing. Methods: We assessed emotion detection, discrimination, matching, selection, and categorization as well as judgments of nonmoral, moral impersonal, moral personal low- and high-conflict scenarios. Results: bvFTD patients gave more utilitarian responses on low-conflict personal moral dilemmas. There was a significant correlation between a facial emotion processing measure derived through principal component analysis and utilitarian responses on low-conflict personal scenarios in the bvFTD group (controlling for MMSE-score and syntactic abilities)...
December 2017: Brain and Behavior
Jing Tao, Xiangli Chen, Jiao Liu, Natalia Egorova, Xiehua Xue, Weilin Liu, Guohua Zheng, Ming Li, Jinsong Wu, Kun Hu, Zengjian Wang, Lidian Chen, Jian Kong
Age-related cognitive decline is a significant public health concern. Recently, non-pharmacological methods, such as physical activity and mental training practices, have emerged as promising low-cost methods to slow the progression of age-related memory decline. In this study, we investigated if Tai Chi Chuan (TCC) and Baduanjin modulated the fractional amplitude of low-frequency fluctuations (fALFF) in different frequency bands (low-frequency: 0.01-0.08 Hz; slow-5: 0.01-0.027 Hz; slow-4: 0.027-0.073 Hz) and improved memory function...
2017: Frontiers in Human Neuroscience
Mingli Li, Wei Deng, Tushar Das, Yinfei Li, Liansheng Zhao, Xiaohong Ma, Yingcheng Wang, Hua Yu, Xiaojing Li, Ya-Jing Meng, Qiang Wang, Lena Palaniyappan, Tao Li
Developing a mechanistic insight into the specific brain processes that underpin improvement in negative symptoms can help us design novel chemical and physical treatments against these unrelenting symptoms. The aim of the present study is to explore the longitudinal changes in the brain's regional functional efficiency that accompany improvement in negative symptoms seen in first-episode patients with schizophrenia when treated with antipsychotic for 1 year. Forty-seven first-episode patients with schizophrenia were scanned at a drug-naive baseline state and followed up for 1 year to identify negative symptom responders (Rn) and non-responders (NRn)...
November 11, 2017: European Archives of Psychiatry and Clinical Neuroscience
Junya Fujino, Shisei Tei, Kathryn F Jankowski, Ryosaku Kawada, Toshiya Murai, Hidehiko Takahashi
We are constantly exposed to socially conflicting situations in everyday life, and cognitive flexibility is essential for adaptively coping with such difficulties. Flexible goal choice and pursuit are not exclusively conscious, and therefore cognitive flexibility involves both explicit and implicit forms of processing. However, it is unclear how individual differences in explicit and implicit aspects of flexibility are associated with neural activity in a resting state. Here, we measured intrinsic fractional amplitude of low-frequency fluctuations (fALFF) by resting-state functional magnetic resonance imaging (RS-fMRI) as an indicator of regional brain spontaneous activity, together with explicit and implicit aspects of cognitive flexibility using the Cognitive Flexibility Scale (CFS) and Implicit Association Test (IAT)...
December 26, 2017: Neuroscience
Shaojia Lu, Fen Pan, Weijia Gao, Zhaoguo Wei, Dandan Wang, Shaohua Hu, Manli Huang, Yi Xu, Lingjiang Li
The aim of this study was to investigate the relationship among childhood trauma, executive impairments, and altered resting-state brain function in young healthy adults. Twenty four subjects with childhood trauma and 24 age- and gender-matched subjects without childhood trauma were recruited. Executive function was assessed by a series of validated test procedures. Localized brain activity was evaluated by fractional amplitude of low frequency fluctuation (fALFF) method and compared between two groups. Areas with altered fALFF were further selected as seeds in subsequent functional connectivity analysis...
October 3, 2017: Oncotarget
Zhujing Shen, Peiyu Huang, Chao Wang, Wei Qian, Xiao Luo, Xiaojun Guan, Tiantian Qiu, Yihong Yang, Minming Zhang
Tobacco use disorder is frequently comorbid with emotional disorders, each exerting reciprocal influence on the other. As an important hub for emotional processing, amygdala may also play a critical role in tobacco addiction. Therefore, we aimed to investigate the volume and spontaneous activity of the amygdala in nicotine-dependent individuals and their relationships with cigarette use. A total of 84 smokers (aged 22-54 years) and 41 nonsmokers (aged 26-56 years) were enrolled in the present study. 3D-T1 weighted images and resting-state fMRI images were acquired from all participants...
December 2017: Neuropsychologia
Marcelo Q Hoexter, Claudinei E Biazoli, Pedro G Alvarenga, Marcelo C Batistuzzo, Giovanni A Salum, Ary Gadelha, Pedro M Pan, Mauricio Anés, Leticia Mancini-Martins, Luciana M Moura, Carles Soriano-Mas, Marco A G Del' Aquilla, Edson Amaro, Luis A Rohde, Andrea P Jackowski, Rodrigo A Bressan, Euripedes C Miguel, Maria C do Rosario, João R Sato
BACKGROUND: The present study was designed to explore alterations in brain dynamics at rest that are associated with Obsessive Compulsive Symptoms (OCS) in childhood by measuring low frequency fluctuation of spontaneous brain activity in a large school community sample from a developing country. METHOD: Resting state functional magnetic resonance imaging data were collected in a sample of 655 children and adolescents (6-15 years old) from the brazilian 'High Risk Cohort Study for Psychiatric Disorders (HRC)'...
October 16, 2017: Journal of Psychiatric Research
Peng-Fei Qiao, Guang-Ming Niu
OBJECTIVE: To detect resting-state functional MRI (rsfMRI) changes and their relationships with the clinical curative effect of anti-epileptic drugs (AEDs) for complex partial seizures (CPS) in epilepsy patients using the fractional amplitude of low frequency fluctuation (fALFF). METHODS: rfMRI data from 14 CPS patients enrolled between June 2015 and June 2016 in Department of Neurology, Affiliated Hospital of Inner Mongolia Medical University were retrospectively investigated and compared with findings from 14 healthy age-, gender-, handedness-, and education-matched subjects...
October 2017: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
Yan Sun, Congcong Zhang, Shuxia Duan, Xiaoxia Du, Vince D Calhoun
The aim of this study was to investigate the spontaneous neural activity and functional connectivity (FC) in heavy metal music lovers (HMML) compared with classical music lovers (CML) during resting state. Forty HMML and 31 CML underwent resting-state functional MRI scans. Fractional amplitude of low-frequency fluctuations (fALFF) and seed-based resting-state FC were computed to explore regional activity and functional integration. A voxel-based two-sample t-test was used to test the differences between the two groups...
September 18, 2017: Neuroreport
Ming-Fei Ni, Xiao-Feng Huang, Yan-Wei Miao, Zhan-Hua Liang
Primary blepharospasm (BPS) is a focal dystonia characterized by involuntary eyelid spasms and blinking. The pathophysiology of BPS remains unclear. Several functional and structural neuroimaging studies have demonstrated abnormalities of sensorimotor structures such as the sensorimotor cortex, the basal ganglia, the thalamus and the cerebellum in BPS patients. However, some of the results of these studies were inconsistent. In addition, the relationship between the motor and sensory structures in patients with BPS still needs to be investigated...
November 1, 2017: Neuroscience Letters
Song Wang, Ming Zhou, Taolin Chen, Xun Yang, Guangxiang Chen, Qiyong Gong
As a component of self-regulation, delay discounting (DD) refers to an individual's tendency to prefer smaller-but-sooner rewards over larger-but-later rewards and plays an essential role in many aspects of human behavior. Although numerous studies have examined the neural underpinnings of DD in adults, there are far fewer studies focusing on the neurobiological correlates underlying DD in adolescents. Here, we investigated the associations between individual differences in DD and the fractional amplitude of low-frequency fluctuations (fALFF) and resting-state functional connectivity (RSFC) in 228 high school students using resting-state functional magnetic resonance imaging (RS-fMRI)...
August 31, 2017: Scientific Reports
Yun Fei Wang, Xiang Kong, Guang Ming Lu, Long Jiang Zhang
Recent studies showed many cirrhosis patients may have diabetes mellitus (DM), however, the effect of DM on brain in cirrhotic patients is unclear. This study included 34 cirrhosis patients (17 with DM, 17 without DM) and 17 age-, sex-matched healthy controls. MRI examination and neuropsychological tests were performed. Fractional amplitude of low-frequency fluctuation (fALFF) and voxel-based morphometry algorithms were used to obtain fALFF values and gray matter volume, which were compared and correlated with clinical variables...
August 10, 2017: Scientific Reports
Natalia Egorova, Michele Veldsman, Toby Cumming, Amy Brodtmann
Depression is a common outcome following stroke, associated with reduced quality of life and poorer recovery. Despite attempts to associate depression symptoms with specific lesion sites, the neural basis of post-stroke depression remains poorly understood. Resting state fMRI has provided new insights into the neural underpinnings of post-stroke depression, but has been limited to connectivity analyses exploring interregional correlations in the time-course of activity. Other aspects of resting state BOLD signal remain unexamined...
2017: NeuroImage: Clinical
Y J Zhu, G L Ma, T B Song, L Du, R C Guo, S L Sun, H Li, L G Sun
Objective: To analysis the change of brain functional activity in the left and right peripheral facial paralysis by using resting-state functional magnetic resonance imaging (R-fMRI) of fraction amplitude of low frequency fluctuation(fALFF) measurement technique, and research the abnormal brain region with different side patients whether there are differences. Methods: A total of 43 patients with peripheral facial paralysis patients (patient groups, divided into left / right two subgroups) and 21 healthy volunteers (control group) in this study...
July 18, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Jia-Sheng Rao, Zuxiang Liu, Can Zhao, Rui-Han Wei, Wen Zhao, Peng-Yu Tian, Xia Zhou, Zhao-Yang Yang, Xiao-Guang Li
OBJECTIVE: Ketamine is a well-known anesthetic. 'Recreational' use of ketamine common induces psychosis-like symptoms and cognitive impairments. The acute and chronic effects of ketamine on relevant brain circuits have been studied, but the effects of single-dose ketamine administration on the local resting-state functional properties of the brain remain unknown. In this study, we aimed to assess the effects of single-dose ketamine administration on the brain local intrinsic properties...
November 2017: Magnetic Resonance Imaging
Gao-Xia Wei, Zhu-Qing Gong, Zhi Yang, Xi-Nian Zuo
Cognitive control impairment is a typical symptom largely reported in populations with neurological disorders. Previous studies have provided evidence about the changes in cognitive control induced by mind-body training. However, the neural correlates underlying the effect of extensive mind-body practice on cognitive control remain largely unknown. Using resting-state functional magnetic resonance imaging, we characterized dynamic fluctuations in large-scale intrinsic connectivity networks associated with mind-body practice, and examined their differences between healthy controls and Tai Chi Chuan (TCC) practitioners...
2017: Frontiers in Psychology
Song Cao, Ying Li, Wenwen Deng, Bangyong Qin, Yi Zhang, Peng Xie, Jie Yuan, Buwei Yu, Tian Yu
BACKGROUND: Herpes zoster (HZ) can develop into postherpetic neuralgia (PHN), both of which are painful diseases. PHN patients suffer chronic pain and emotional disorders. Previous studies showed that the PHN brain displayed abnormal activity and structural change, but the difference in brain activity between HZ and PHN is still not known. OBJECTIVES: To identify regional brain activity changes in HZ and PHN brains with resting-state functional magnetic resonance imaging (rs-fMRI) technique, and to observe the differences between HZ and PHN patients...
July 2017: Pain Physician
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