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https://www.readbyqxmd.com/read/28199371/the-value-of-resting-state-functional-magnetic-resonance-imaging-for-detecting-epileptogenic-zones-in-patients-with-focal-epilepsy
#1
Zhijuan Chen, Yang An, Bofeng Zhao, Weidong Yang, Qing Yu, Li Cai, Hongyan Ni, Jianzhong Yin
OBJECTIVE: To determine the value of resting-state functional magnetic resonance imaging (RS-fMRI) based on the local analysis methods regional homogeneity (ReHo), amplitude of low-frequency fluctuations (ALFF), and fractional ALFF (fALFF), for detecting epileptogenic zones (EZs). METHODS: A total of 42 consecutive patients with focal epilepsy were enrolled. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of visually assessed RS-fMRI, MRI, magnetic resonance spectroscopy (MRS), video electroencephalography (VEEG), and positron-emission tomography computed tomography (PET-CT) in EZ localization were evaluated to assess their diagnostic abilities...
2017: PloS One
https://www.readbyqxmd.com/read/28192860/amplitude-of-low-frequency-fluctuations-during-resting-state-differentially-predicts-authentic-and-hubristic-pride
#2
Feng Kong, Qiaolin He, Xiqin Liu, Xiayu Chen, Xu Wang, Jingjing Zhao
OBJECTIVE: Pride is an important self-conscious emotion and comprised of two distinct conceptual facets: arrogant, egotistic "hubristic pride", and pro-social, achievement-oriented "authentic pride". However, little is known about the neural basis of two facets of pride. Here we investigated the association between spontaneous brain activity and these two facets of pride in resting state. METHOD: We measured 276 participants on authentic and hubristic pride. The fractional amplitude of low frequency fluctuations (fALFF) was used to identify pride-related regions...
February 13, 2017: Journal of Personality
https://www.readbyqxmd.com/read/28174129/intrinsic-cerebral-activity-at-resting-state-in-adults-with-major-depressive-disorder-a-meta-analysis
#3
Ming Zhou, Xinyu Hu, Lu Lu, Lianqing Zhang, Lizhou Chen, Qiyong Gong, Xiaoqi Huang
Numerous neuroimaging studies have been undertaken to detect cerebral intrinsic activity in major depressive disorder (MDD) with resting state fMRI (rs-fMRI). However, the inconsistent results have hindered our understanding of the exact neuropathology related to MDD. The current meta-analysis used state-of-the-art conjunction analysis techniques to systematically review and summarize all available neuroimaging studies using rs-fMRI with amplitude of low frequency fluctuation (ALFF) and/or fractional ALFF (fALFF) on MDD patients and further explored the effect of antidepressants on the intrinsic activity of the brain...
February 4, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28158166/abnormal-local-brain-activity-beyond-the-pain-matrix-in-postherpetic-neuralgia-patients-a-resting-state-functional-mri-study
#4
Song Cao, Ganjun Song, Yi Zhang, Peng Xie, Ye Tu, Ying Li, Tian Yu, Buwei Yu
BACKGROUND: Postherpetic neuralgia (PHN) patients suffer debilitating chronic pain, hyperalgesia, and allodynia, as well as emotional disorders such as insomnia, anxiety, and depression. The brain structure and functional basis of PHN are still not fully understood. OBJECTIVES: To identify the changes of regional brain activity in resting-state PHN patients using regional homogeneity (ReHo) and fractional aptitude of low-frequency fluctuation (fALFF) methods. Correlations between spontaneous pain intensity and ReHo or fALFF were analyzed...
February 2017: Pain Physician
https://www.readbyqxmd.com/read/28139359/altered-amplitude-of-low-frequency-fluctuations-in-schizophrenia-patients-with-persistent-auditory-verbal-hallucinations
#5
Anna Alonso-Solís, Yolanda Vives-Gilabert, Maria J Portella, Mireia Rabella, Eva M Grasa, Alexandra Roldán, Alejandro Keymer-Gausset, Conrad Molins, Fidel Núñez-Marín, Beatriz Gómez-Ansón, Enric Alvarez, Iluminada Corripio
The aim of this study is to analyze the differences in low frequency fluctuation (LFF) values between schizophrenia patients with and without auditory verbal hallucinations (AVH). Nineteen schizophrenia patients with persistent AVH (HP), fourteen non-hallucinating schizophrenia patients (nHP) and twenty healthy controls (HC) underwent R-fMRI. LFF values were calculated in the slow frequency band (0.01-0.08Hz). By means of group level contrasts, we performed direct voxel-wise group comparisons. Both groups of patients showed decreased amplitude LFF (ALFF) values in the occipital pole and lingual gyrus compared to HC, whereas increased ALFF values were found in the temporal pole and fusifom gyrus...
January 28, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28117505/age-associated-patterns-in-gray-matter-volume-cerebral-perfusion-and-bold-oscillations-in-children-and-adolescents
#6
Signe Bray
Healthy brain development involves changes in brain structure and function that are believed to support cognitive maturation. However, understanding how structural changes such as grey matter thinning relate to functional changes is challenging. To gain insight into structure-function relationships in development, the present study took a data driven approach to define age-related patterns of variation in gray matter volume (GMV), cerebral blood flow (CBF) and blood-oxygen level dependent (BOLD) signal variation (fractional amplitude of low-frequency fluctuations; fALFF) in 59 healthy children aged 7-18 years, and examined relationships between modalities...
January 24, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28104431/abnormal-regional-spontaneous-neuronal-activity-associated-with-symptom-severity-in-treatment-naive-patients-with-obsessive-compulsive-disorder-revealed-by-resting-state-functional-mri
#7
Linlin Qiu, Xiangshuai Fu, Shuai Wang, Qunfeng Tang, Xingui Chen, Lin Cheng, Fuquan Zhang, Zhenhe Zhou, Lin Tian
A large number of neuroimaging studies have revealed the dysfunction of brain activities in obsessive-compulsive disorder (OCD) during various tasks. However, regional spontaneous activity abnormalities in OCD are gradually being revealed. In this current study, we aimed to investigate cerebral regions with abnormal spontaneous activity using resting-state functional magnetic resonance imaging (fMRI) and further explored the relationship between the spontaneous neuronal activity and symptom severity of patients with OCD...
January 16, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28098938/towards-prognostic-biomarkers-from-bold-fluctuations-to-differentiate-a-first-epileptic-seizure-from-new-onset-epilepsy
#8
Lalit Gupta, Rick Janssens, Mariëlle C G Vlooswijk, Rob P W Rouhl, Anton de Louw, Albert P Aldenkamp, Shrutin Ulman, René M H Besseling, Paul A M Hofman, Vivianne H van Kranen-Mastenbroek, Danny M Hilkman, Jacobus F A Jansen, Walter H Backes
OBJECTIVE: The diagnosis of epilepsy cannot be reliably made prior to a patient's second seizure in most cases. Therefore, adequate diagnostic tools are needed to differentiate subjects with a first seizure from those with a seizure preceding the onset of epilepsy. The objective was to explore spontaneous blood oxygen level-dependent (BOLD) fluctuations in subjects with a first-ever seizure and patients with new-onset epilepsy (NOE), and to find characteristic biomarkers for seizure recurrence after the first seizure...
January 18, 2017: Epilepsia
https://www.readbyqxmd.com/read/28094810/aberrant-development-of-intrinsic-brain-activity-in-a-rat-model-of-caregiver-maltreatment-of-offspring
#9
C-G Yan, M Rincón-Cortés, C Raineki, E Sarro, S Colcombe, D N Guilfoyle, Z Yang, S Gerum, B B Biswal, M P Milham, R M Sullivan, F X Castellanos
Caregiver maltreatment induces vulnerability to later-life psychopathology. Clinical and preclinical evidence suggest changes in prefrontal and limbic circuitry underlie this susceptibility. We examined this question using a rat model of maternal maltreatment and methods translated from humans, resting-state functional magnetic resonance imaging (R-fMRI). Rat pups were reared by mothers provided with insufficient or abundant bedding for nest building from postnatal (PN) days 8 to 12 and underwent behavioral assessments of affect-related behaviors (forced swim, sucrose preference and social interaction) in adolescence (PN45) and early adulthood (PN60)...
January 17, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28077184/abnormalities-in-the-effective-connectivity-of-visuothalamic-circuitry-in-schizophrenia
#10
S J Iwabuchi, L Palaniyappan
BACKGROUND: Sensory-processing deficits appear crucial to the clinical expression of symptoms of schizophrenia. The visual cortex displays both dysconnectivity and aberrant spontaneous activity in patients with persistent symptoms and cognitive deficits. In this paper, we examine visual cortex in the context of the remerging notion of thalamic dysfunction in schizophrenia. We examined specific regional and longer-range abnormalities in sensory and thalamic circuits in schizophrenia, and whether these patterns are strong enough to discriminate symptomatic patients from controls...
January 12, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28077120/altered-fractional-amplitude-of-low-frequency-fluctuation-associated-with-cognitive-dysfunction-in-first-episode-drug-na%C3%A3-ve-major-depressive-disorder-patients
#11
Manli Huang, Shaojia Lu, Liang Yu, Lingjiang Li, Peng Zhang, Jianbo Hu, Weihua Zhou, Shaohua Hu, Ning Wei, Jinwen Huang, Jian Weng, Yi Xu
BACKGROUND: Previous studies have demonstrated that abnormities of both resting-state brain activity and cognitive dysfunction are frequently observed in patients with major depressive disorder (MDD). However, the underlying relationship between these two aspects is less investigated. In this context, the aim of the present study was to investigate the association between cognitive dysfunction and altered resting-state brain function in first-episode drug-naïve MDD patients. METHODS: Twenty-five drug-naïve MDD patients and twenty-six age-, sex-, and education-matched normal controls were recruited in this study...
January 11, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28057091/-resting-state-functional-magnetic-resonance-study-of-brain-function-changes-after-tips-operation-in-patients-with-liver-cirrhosis
#12
C Liu, H B Wang, Y Q Yu, M Q Wang, G B Zhang, L Y Xu, J M Wu
Objective: To investigate the brain function changes in cirrhosis patients after transjugular intrahepatic portosystemic shunt (TIPS), resting-state functional MRI (rs-fMRI) performed and fractional amplitude of low frequency fluctuation (fALFF) was analyzed. Methods: From January 2014 to February 2016, a total of 96 cirrhotic patients from invasive technology department and infection department in the First Affiliated Hospital of Anhui Medical University were selected , the blood ammonia data of 96 cirrhotic patients with TIPS operation in four groups were collected after 1, 3, 6 and 12 month, and all subjects performed rs-fMRI scans...
December 20, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28048305/su-f-j-139-amplitude-of-low-frequency-fluctuation-alff-and-regional-homogeneity-reho-study-of-the-respiration-motion-control-byhypnosis
#13
Y Liu, R Li, Y Xie
PURPOSE: Respiration control by hypnosis is a method in reducing the detriment to the healthy organs or organizations for patients during radiotherapy, especially for lung and abdomen cancer (Fig.1). It's hypothesized that there exists alterations neurological brain activity during the hypnosis state of respiratory motion control in comparison with resting state. METHODS: Thirteen healthy volunteers were organized to participate in a hypnosis experiment that consisted of two sectional scans of functional magnetic resonance imaging (fMRI), rest state condition (RSC) scanning and hypnosis state condition (HSC) scanning...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27993673/propofol-attenuates-low-frequency-fluctuations-of-resting-state-fmri-bold-signal-in-the-anterior-frontal-cortex-upon-loss-of-consciousness
#14
Xiaolin Liu, Kathryn K Lauer, B Douglas Ward, Christopher Roberts, Suyan Liu, Suneeta Gollapudy, Robert Rohloff, William Gross, Guangyu Chen, Zhan Xu, Jeffrey R Binder, Shi-Jiang Li, Anthony G Hudetz
Recent studies indicate that spontaneous low-frequency fluctuations (LFFs) of resting-state functional magnetic resonance imaging (rs-fMRI) blood oxygen level-dependent (BOLD) signals are driven by the slow (<0.1Hz) modulation of ongoing neuronal activity synchronized locally and across remote brain regions. How regional LFFs of the BOLD fMRI signal are altered during anesthetic-induced alteration of consciousness is not well understood. Using rs-fMRI in 15 healthy participants, we show that during administration of propofol to achieve loss of behavioral responsiveness indexing unconsciousness, the fractional amplitude of LFF (fALFF index) was reduced in comparison to wakeful baseline in the anterior frontal regions, temporal pole, hippocampus, parahippocampal gyrus, and amygdala...
February 15, 2017: NeuroImage
https://www.readbyqxmd.com/read/27903342/-fractional-amplitude-of-low-frequency-fluctuations-in-childhood-and-adolescence-onset-schizophrenia-a-resting-state-fmri-study
#15
D Lü, R R Shao, Y H Liang, Y H Xia, S Q Guo
Objective: To explore the whole brain activity features of childhood and adolescence-onset schizophrenia using resting state fMRI. Methods: A total of 63 childhood and adolescence-onset schizophrenia patients (patients group), admitted to the second affiliated hospital of Xinxiang Medical University from October 2013 to October 2015 and fulfilled our inclusion criteria, and 39 healthy controls with age, sex and education matched (control group) were enrolled, then a resting-state fMRI scan was conducted for each participant...
November 22, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27878584/altered-intrinsic-brain-activity-after-chemotherapy-in-patients-with-gastric-cancer-a-preliminary-study
#16
Hyun Gi Kim, Na-Young Shin, Yunjin Bak, Kyung Ran Kim, Young-Chul Jung, Kyunghwa Han, Seung-Koo Lee, Soo Mee Lim
OBJECTIVES: To characterize the pattern of altered intrinsic brain activity in gastric cancer patients after chemotherapy (CTx). METHODS: Patients before and after CTx (n = 14) and control subjects (n = 11) underwent resting-state functional MRI (rsfMRI) at baseline and 3 months after CTx. Regional homogeneity (ReHo), amplitude of low-frequency fluctuation (ALFF), and fractional ALFF (fALFF) were calculated and compared between the groups using the two-sample t test...
November 23, 2016: European Radiology
https://www.readbyqxmd.com/read/27771857/brain-alterations-in-low-frequency-fluctuations-across-multiple-bands-in-obsessive-compulsive-disorder
#17
Mònica Giménez, Andrés Guinea-Izquierdo, Victoria Villalta-Gil, Ignacio Martínez-Zalacaín, Cinto Segalàs, Marta Subirà, Eva Real, Jesús Pujol, Ben J Harrison, Josep Maria Haro, Joao R Sato, Marcelo Q Hoexter, Narcís Cardoner, Pino Alonso, José Manuel Menchón, Carles Soriano-Mas
The extent of functional abnormalities in frontal-subcortical circuits in obsessive-compulsive disorder (OCD) is still unclear. Although neuroimaging studies, in general, and resting-state functional Magnetic Resonance Imaging (rs-fMRI), in particular, have provided relevant information regarding such alterations, rs-fMRI studies have been typically limited to the analysis of between-region functional connectivity alterations at low-frequency signal fluctuations (i.e., <0.08 Hz). Conversely, the local attributes of Blood Oxygen Level Dependent (BOLD) signal across different frequency bands have been seldom studied, although they may provide valuable information...
October 22, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27734308/functional-mri-signal-fluctuations-highlight-altered-resting-brain-activity-in-huntington-s-disease
#18
Chiara Sarappa, Elena Salvatore, Alessandro Filla, Sirio Cocozza, Cinzia Valeria Russo, Francesco Saccà, Arturo Brunetti, Giuseppe De Michele, Mario Quarantelli
The fractional Amplitude of Low Frequency Fluctuations (fALFF) and the degree of local synchronization (Regional Homogeneity - ReHo) of resting-state BOLD signal have been suggested to map spontaneous neuronal activity and local functional connectivity, respectively. We compared voxelwise, independent of atrophy, the fALFF and ReHo patterns of 11 presymptomatic (ps-HD) and 28 symptomatic (sHD) Huntington's disease mutation carriers, with those of 40 normal volunteers, and tested their possible correlations with the motor and cognitive subscores of the Unified Huntington's Disease Rating Scale...
October 12, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27718507/a-resting-state-fmri-study-of-obese-females-between-pre-and-postprandial-states-before-and-after-bariatric-surgery
#19
Lyle Wiemerslage, Wei Zhou, Gaia Olivo, Julia Stark, Pleunie S Hogenkamp, Elna-Marie Larsson, Magnus Sundbom, Helgi B Schiöth
Past studies utilizing resting-state functional MRI (rsfMRI), have shown that obese humans exhibit altered activity in brain areas related to reward compared to normal-weight controls. However, to what extent bariatric surgery-induced weight loss alters resting-state brain activity in obese humans is less well-studied. Thus, we measured the fractional amplitude of low-frequency fluctuations from eyes-closed, rsfMRI in obese females (n = 11, mean age = 42 years, mean BMI = 41 kg/m(2) ) in both a pre- and postprandial state at two time points: four weeks before, and four weeks after bariatric surgery...
October 8, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27716674/insula-and-inferior-frontal-gyrus-activities-protect-memory-performance-against-alzheimer-s-disease-pathology-in-old-age
#20
Feng Lin, Ping Ren, Raymond Y Lo, Benjamin P Chapman, Alanna Jacobs, Timothy M Baran, Anton P Porsteinsson, John J Foxe
Apolipoprotein E (APOE) ɛ4 carriers and patients with amnestic mild cognitive impairment (MCI) have high risk of developing Alzheimer's disease (AD). The Scaffolding Theory of Aging and Cognition proposes that recruitment of additional frontal brain regions can protect cognition against aging. This thesis has yet to be fully tested in older adults at high risk for AD. In the present study, 75 older participants (mean age: 74 years) were included. Applying a voxel-wise approach, fractional amplitude of low-frequency fluctuations (fALFF) in resting-state functional neuroimaging data were analyzed as a function of APOEɛ4 status (carrier versus noncarrier) and clinical status (healthy control [HC] versus MCI) using a 2×2 analysis of covariance (ANCOVA)...
2017: Journal of Alzheimer's Disease: JAD
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