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pregnancy and sickle cell disease

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https://www.readbyqxmd.com/read/27913538/sickle-cell-disease-when-and-how-to-transfuse
#1
Jo Howard
Blood transfusion remains an important therapeutic intervention in patients with sickle cell disease (SCD), aiming to both increase the oxygen carrying capacity of blood and to reduce the complications of vaso-occlusion. Simple, manual exchange and automated exchange can be effective in reducing the acute and chronic complications of SCD, and the advantages and disadvantages of each methodology mean they all have a role in different situations. Evidence for the role of emergency transfusion in the management of the acute complications of SCD, including acute pain and acute chest syndrome, comes from observational data...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27829875/mildly-raised-tricuspid-regurgitant-velocity-2-5-3-0%C3%A2-m-s-in-pregnant-women-with-sickle-cell-disease-is-not-associated-with-poor-obstetric-outcome-an-observational-cross-sectional-study
#2
May C Soh, Srividhya Sankaran, Natali Ya Chung, Catherine Nelson-Piercy, Jo Howard, Sue E Robinson, Eugene Oteng-Ntim
Pulmonary hypertension is associated with 36% mortality in pregnancy, and 6-10% of patients with sickle cell disease have pulmonary hypertension. Tricuspid regurgitant velocity ≥2.5 m/s on echocardiography is a well validated means of screening for pulmonary hypertension in the non-pregnant population. This is a pilot study to determine if this is a useful non-invasive screening test for pulmonary hypertension in pregnancy, and whether raised tricuspid regurgitant velocity ≥2.5 m/s was associated with poor outcomes...
December 2016: Obstetric Medicine
https://www.readbyqxmd.com/read/27796349/heme-mediated-apoptosis-and-fusion-damage-in-bewo-trophoblast-cells
#3
Mingli Liu, Salifu Hassana, Jonathan K Stiles
Placental malaria (PM) is a complication associated with malaria infection during pregnancy that often leads to abortion, premature delivery, intrauterine growth restriction and low birth weight. Increased levels of circulating free heme, a by-product of Plasmodium-damaged erythrocytes, is a major contributor to inflammation, tissue damage and loss of blood brain barrier integrity associated with fatal experimental cerebral malaria. However, the role of heme in PM remains unknown. Proliferation and apoptosis of trophoblasts and fusion of the mononucleated state to the syncytial state are of major importance to a successful pregnancy...
October 31, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27776167/birth-weights-in-sickle-cell-disease-pregnancies-a-cohort-study
#4
Daveena Meeks, Susan E Robinson, David Macleod, Eugene Oteng-Ntim
Pregnancy in women with Sickle Cell Disease (SCD) has been linked with an increased incidence of adverse foetal outcomes when compared to women without haemoglobinopathies (HbAA). There's a paucity of data into foetal outcomes for infants born to women with SCD. Customised growth charts have been demonstrated to be better than population-based growth charts at identifying unhealthy small babies. We analysed the mean birth weight and customised birth weight centiles of infants born to mothers with SCD versus mothers with HbAA genotype, to quantify the risk of having a smaller baby...
2016: PloS One
https://www.readbyqxmd.com/read/27678389/volume-regulatory-hormones-and-plasma-volume-in-pregnant-women-with-sickle-cell-disorder
#5
Bosede B Afolabi, Olajumoke O Oladipo, Alani S Akanmu, Olalekan O Abudu, Olusoga A Sofola, Fiona Broughton Pipkin
BACKGROUND: Sickle cell disease (haemoglobin SS (HbSS)) mainly affects those of West African origin and is associated with hypervolaemia. Plasma volume rises by up to 50% in normal pregnancy but was previously found to be paradoxically contracted in late sickle cell pregnancy. The renin-angiotensin-aldosterone system is activated very early in human pregnancy to support the plasma volume expansion. We hypothesised that activation of the renin-angiotensin-aldosterone system would be blunted in pregnant women with sickle cell disease...
July 2016: Journal of the Renin-angiotensin-aldosterone System: JRAAS
https://www.readbyqxmd.com/read/27598360/sickle-cell-disease-in-pregnancy
#6
Amanda Redden Hathaway
Sickle cell disease (SCD) is the most common hereditary disorder and affects 30 million people worldwide. Advances in science have improved overall survival in patients with SCD and as such, more patients are reaching reproductive age and are becoming pregnant. SCD in pregnancy leads to multiple complications that put both the mother and fetus at risk, and patients with SCD have six times the mortality during pregnancy as compared with patients without SCD. This review summarizes the maternal and fetal risks of patients with SCD and makes recommendations on how best to care for these patients throughout all stages of pregnancy...
September 2016: Southern Medical Journal
https://www.readbyqxmd.com/read/27548360/ten-challenges-in-contraception
#7
Audrey Binette, Kerry Howatt, Ashley Waddington, Robert L Reid
Despite the introduction of promising products into the contraceptive market, the rate of unintended pregnancies remains high. Women with underlying medical conditions should have access to safe and effective contraceptive methods for various reasons, including the potential deleterious effect of the disease on the pregnancy or the effect of the pregnancy on the disease process. Healthcare providers are often confronted with cases in which contraception counseling is problematic due to controversial evidence and persistent myths...
August 22, 2016: Journal of Women's Health
https://www.readbyqxmd.com/read/27546026/abnormal-expression-of-inflammatory-genes-in-placentas-of-women-with-sickle-cell-anemia-and-sickle-hemoglobin-c-disease
#8
Letícia C Baptista, Maria Laura Costa, Regiane Ferreira, Dulcinéia M Albuquerque, Carolina Lanaro, Kleber Y Fertrin, Fernanda G Surita, Mary A Parpinelli, Fernando F Costa, Mônica Barbosa de Melo
Sickle cell disease (SCD) is a complex disease that is characterized by the polymerization of deoxyhemoglobin S, altered red blood cell membrane biology, endothelial activation, hemolysis, a procoagulant state, acute and chronic inflammation, and vaso-occlusion. Among the physiological changes that occur during pregnancy, oxygen is consumed by fetal growth, and pregnant women with SCD are more frequently exposed to low oxygen levels. This might lead to red blood cells sickling, and, consequently, to vaso-occlusion...
October 2016: Annals of Hematology
https://www.readbyqxmd.com/read/27403164/pregnancy-in-sickle-cell-disease-is-a-very-high-risk-situation-an-observational-study
#9
Narcisse Elenga, Aurélie Adeline, John Balcaen, Tania Vaz, Mélanie Calvez, Anne Terraz, Laetitia Accrombessi, Gabriel Carles
Sickle cell disease is a serious genetic disorder affecting 1/235 births in French Guiana. This study aimed to describe the follow-up of pregnancies among sickle cell disease patients in Cayenne Hospital, in order to highlight the most reported complications. 62 records of pregnancies were analyzed among 44 females with sickle cell disease, between 2007 and 2013. Our results were compared to those of studies conducted in Brazil and Guadeloupe. There were 61 monofetal pregnancies and 2 twin pregnancies, 27 pregnancies among women with SS phenotype, 30 SC pregnancies, and five S-beta pregnancies...
2016: Obstetrics and Gynecology International
https://www.readbyqxmd.com/read/27362514/psychometric-evaluation-of-the-patient-reported-outcomes-measurement-information-system-fatigue-short-form-across-diverse-populations
#10
Suzanne Ameringer, R K Elswick, Victoria Menzies, Jo Lynne Robins, Angela Starkweather, Jeanne Walter, Amanda Elswick Gentry, Nancy Jallo
BACKGROUND: The need for reliable, valid tools to measure patient-reported outcomes (PROs) is critical both for research and for evaluating treatment effects in practice. The Patient-Reported Outcomes Measurement Information System Fatigue-Short Form v1.0-Fatigue 7a (PROMIS F-SF) has had limited psychometric evaluation in various populations. OBJECTIVES: The aim of the study is to examine psychometric properties of PROMIS F-SF item responses across various populations...
July 2016: Nursing Research
https://www.readbyqxmd.com/read/27326420/effect-of-granulocyte-colony-stimulating-factor-g-csf-on-ivf-outcomes-in-infertile-women-an-rct
#11
Maryam Eftekhar, Robabe Hosseinisadat, Ramesh Baradaran, Elham Naghshineh
BACKGROUND: Despite major advances in assisted reproductive techniques, the implantation rates remain relatively low. Some studies have demonstrated that intrauterine infusion of granulocyte colony stimulating factor (G-CSF) improves implantation in infertile women. OBJECTIVE: To assess the G-CSF effects on IVF outcomes in women with normal endometrial thickness. MATERIALS AND METHODS: In this randomized controlled clinical trial, 100 infertile women with normal endometrial thickness who were candidate for IVF were evaluated in two groups...
May 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27242200/contemporary-outcomes-of-sickle-cell-disease-in-pregnancy
#12
Kelly Kuo, Aaron B Caughey
BACKGROUND: Data regarding pregnancy outcomes in sickle cell disease are conflicting. Previous studies are limited by small sample size, narrow geographic area, and a wide range of resource availability. OBJECTIVE: The purpose of this study was to examine the association between maternal sickle cell disease and adverse pregnancy outcomes in a contemporary North American cohort. STUDY DESIGN: We performed a retrospective cohort study of 2,027,323 women with singleton pregnancies delivered in California from 2005-2008...
October 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27235631/pregnancy-in-sickle-cell-haemoglobin-c-sc-disease-a-retrospective-study-of-birth-size-and-maternal-weight-gain
#13
Minerva M Thame, Indira Singh-Minott, Clive Osmond, Roxanne H Melbourne-Chambers, Graham R Serjeant
OBJECTIVE: To assess pregnancy and fetal outcomes in Jamaican subjects with sickle cell-haemoglobin C (SC) disease. STUDY DESIGN: A retrospective chart review over 21 years (1992-2012) of all pregnancies in SC disease and a comparison group matched by gender and date of delivery in mothers with a normal haemoglobin (AA) phenotype at the University Hospital of the West Indies, Jamaica. There were 118 pregnancies in 81 patients with SC disease and 110 pregnancies in 110 in the normal comparison group...
August 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27213855/medical-disease-as-a-cause-of-maternal-mortality-the-pre-imminence-of-cardiovascular-pathology
#14
REVIEW
A O Mocumbi, K Sliwa, P Soma-Pillay
Maternal mortality ratio in low- to middle-income countries (LMIC) is 14 times higher than in high-income countries. This is partially due to lack of antenatal care, unmet needs for family planning and education, as well as low rates of birth managed by skilled attendants. While direct causes of maternal death such as complications of hypertension, obstetric haemorrhage and sepsis remain the largest cause of maternal death in LMICs, cardiovascular disease emerges as an important contributor to maternal mortality in both developing countries and the developed world, hampering the achievement of the millennium development goal 5, which aimed at reducing by three-quarters the maternal mortality ratio until the end of 2015...
March 2016: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/27156108/the-role-of-complement-activation-in-thrombosis-and-hemolytic-anemias
#15
REVIEW
John Chapin, Hunter S Terry, Dorothy Kleinert, Jeffrey Laurence
OBJECTIVE: The objective of this study was to describe complement activation in hemostatic and pathologic states of coagulation and in the acquired and congenital hemolytic anemias. METHODS AND RESULTS: We review published and emerging data on the involvement of the classic, alternative and lectin-based complement pathways in coagulation and the hemolytic anemias. The alternative pathway in particular is always "on," at low levels, and is particularly sensitive to hyper-activation in a variety of physiologic and pathologic states including infection, autoimmune disorders, thrombosis and pregnancy, requiring tight control predicated on a variety of soluble and membrane bound regulatory proteins...
April 2016: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/26799428/maternal-opioid-dose-is-associated-with-neonatal-abstinence-syndrome-in-children-born-to-women-with-sickle-cell-disease
#16
Tyler Shirel, Collin P Hubler, Rena Shah, Amy B Mager, Kathryn L Koch, Darshita Sheth, Michael R Uhing, Cresta W Jones, Joshua J Field
The objective of this study was to test the hypothesis that higher daily opioid dose is associated with the presence and severity of neonatal abstinence syndrome (NAS) in pregnant women with sickle cell disease (SCD). This was a retrospective study of pregnant women with SCD who required opioids. NAS was evaluated using the Finnegan scoring system and classified as none, mild, and severe. Severe NAS was defined as a Finnegan score ≥ 8 on 3 consecutive tests. Thirty-four pregnancies were examined in 30 women with SCD...
June 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/26686851/associations-of-body-mass-index-and-gestational-weight-gain-with-term-pregnancy-outcomes-in-urban-cameroon-a-retrospective-cohort-study-in-a-tertiary-hospital
#17
Florent Ymele Fouelifack, Jeanne Hortence Fouedjio, Jovanny Tsuala Fouogue, Zacharie Sando, Loic Dongmo Fouelifa, Robinson Enow Mbu
BACKGROUND: Obesity is a rising public health issue worldwide. Guidelines regarding maternal body mass index (BMI) and gestational weight gain (GWG) are missing in Cameroon where maternal mortality rate remains very high. We hypothesized that obesity and inappropriate GWG are associated with poor pregnancy outcomes. We aimed at assessing associations of BMI and GWG with pregnancy outcomes. METHODS: This was a retrospective cohort study at the Yaoundé Central Hospital...
2015: BMC Research Notes
https://www.readbyqxmd.com/read/26672916/pregnancy-and-sickle-cell-disease-a-review-of-the-current-literature
#18
REVIEW
Can Boga, Hakan Ozdogu
Sickle cell disease (SCD) is the most common hereditary disease worldwide, presenting with anemia and intermittent severe pain. Pregnancy in a patient with SCD is associated with high levels of maternal and fetal morbidity and mortality; the maternal and fetal death rates during pregnancy can attain 11.4% and 20%, respectively. Patient care has improved over time. However, certain management issues remain unresolved; these include the optimum policy in terms of prophylactic blood transfusion, and the use of antiplatelet drugs...
February 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/26667608/pregnancy-outcomes-in-women-with-sickle-cell-disease-in-low-and-high-income-countries-a%C3%A2-systematic-review-and-meta-analysis
#19
REVIEW
T K Boafor, E Olayemi, N Galadanci, C Hayfron-Benjamin, Y Dei-Adomakoh, C Segbefia, A A Kassim, M H Aliyu, H Galadanci, M G Tuuli, M Rodeghier, Michael R DeBaun, S A Oppong
BACKGROUND: Pregnancy in women with sickle-cell disease (SCD) is associated with increased adverse outcomes. Findings on the association between SCD and adverse pregnancy outcomes are conflicting, and the results do not address whether these associations are similar in both low- and high-income countries. OBJECTIVES: We conducted a systematic review and meta-analysis to evaluate pregnancy outcomes associated with SCD. SEARCH STRATEGY: The MEDLINE database was searched using medical subject headings (MeSH) and keywords for articles on pregnancy outcomes in women with SCD...
April 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/26637755/optimizing-hydroxyurea-therapy-for-sickle-cell-anemia
#20
Russell E Ware
Hydroxyurea has proven efficacy in numerous clinical trials as a disease-modifying treatment for patients with sickle cell anemia (SCA) but is currently under-used in clinical practice. To improve the effectiveness of hydroxyurea therapy, efforts should be directed toward broadening the clinical treatment indications, optimizing the daily dosage, and emphasizing the benefits of early and extended treatment. Here, various issues related to hydroxyurea treatment are discussed, focusing on both published evidence and clinical experience...
2015: Hematology—the Education Program of the American Society of Hematology
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