Henry N Njuguna, Sherif R Zaki, Drucilla J Roberts, Emily A Rogena, Edwin Walong, Corinne L Fligner, M Kelly Keating, Andrew K Gachii, Elizabeth Maleche-Obimbo, Grace Irimu, John Mathaiya, Noelle Orata, Rosemarie Lopokoiyit, Jackson Michuki, Gideon O Emukule, Clayton O Onyango, Stella Gikunju, Collins Owuor, Peter K Muturi, Milka Bunei, Maria Gloria Carvalho, Barry Fields, Joshua A Mott, Marc-Alain Widdowson, Sandra S Chaves
BACKGROUND: In resource-limited settings, acute respiratory infections continue to be the leading cause of death in young children. We conducted postmortem investigations in children <5 years hospitalized with a clinical diagnosis of respiratory disease at Kenya's largest referral hospital. METHODS: We collected respiratory and other tissues postmortem to examine pathologic processes using histology, molecular and immunohistochemistry assays. Nasopharyngeal, trachea, bronchi and lung specimens were tested using 21-target respiratory pathogen real-time reverse transcription polymerase chain reaction assays deployed on Taqman Array Cards...
May 4, 2021: Pediatric Infectious Disease Journal