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aids, hepatitis, hcv , hospital infection

Daniel Fuster, Arantza Sanvisens, Ferran Bolao, Paola Zuluaga, Inmaculada Rivas, Magi Farré, Jordi Tor, Robert Muga
BACKGROUND: The health burden of cannabis use in patients with other substance dependencies is not fully understood. OBJECTIVE: To assess the impact of cannabis use as secondary drug on mortality of patients with other major substance use disorders. PARTICIPANTS: Patients with opiate, cocaine, or alcohol dependence admitted to detoxification from 2001 to 2010 at a teaching hospital in Badalona, Spain. MAIN MEASUREMENTS: Sociodemographic characteristics, drug use, medical comorbidities, and urine drug screens were obtained at admission...
October 6, 2016: Journal of Addiction Medicine
Héctor Meijide, Álvaro Mena, Iria Rodríguez-Osorio, Sonia Pértega, Ángeles Castro-Iglesias, Guillermo Rodríguez-Martínez, José Pedreira, Eva Poveda
BACKGROUND: New patterns in epidemiological characteristics of people living with HIV infection (PLWH) and the introduction of Highly Active Antiretroviral Therapy (HAART) have changed the profile of hospital admissions in this population. The aim of this study was to evaluate trends in hospital admissions, re-admissions, and mortality rates in HIV patients and to analyze the role of HCV co-infection. METHODS: A retrospective cohort study conducted on all hospital admissions of HIV patients between 1993 and 2013...
September 5, 2016: Enfermedades Infecciosas y Microbiología Clínica
Juan S Calle Toro, Diana M Davalos, Jose D Charry, Ana M Arrunategi, Gabriel Tobon
Approximately 80% of patients with hepatitis C virus infection develop chronic liver disease as cirrhosis, and 40% develop autoimmune complications as mixed cryoglobulinemia (MC). Gastrointestinal involvement in MC is rare, and even more so is hepatic involvement. We report a case of an 87-year-old woman with a 10-year history of blood transfusion-acquired hepatitis C virus infection, without treatment. She consulted the emergency department for diffuse abdominal pain, associated with vomiting. After 2 weeks of hospitalization in the intensive care unit, a diagnosis of MC was made; cirrhosis and secondary mesenteric and hepatic vasculitis were confirmed by a diagnostic laparoscopy...
June 2016: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
Sarah Sabouri, Ali Delavar, Hossain Jabbari
BACKGROUND: The aim of this study was to compare the quality of life (QOL) of people infected with both hepatitis C virus (HCV) and human immunodeficiency virus (HIV). The study design was a cross sectional descriptive survey, using self administered questionnaires. MATERIALS AND METHODS: A convenience sample of 242 patients (131 of them HIV/HCV), Iranian adults (aged 18-57) living with HIV/AIDS, was recruited from outpatient referring to Imam Khomeini Hospital behavioral counseling center in Tehran city, Iran...
January 2016: Nigerian Medical Journal: Journal of the Nigeria Medical Association
Seng Gee Lim
The recent outbreak of hepatitis C virus (HCV) at Singapore General Hospital (SGH) has highlighted the dangers of viral hepatitis. In this case, infection control and environmental contamination were the culprits, particularly, a drop of blood containing 5 million IU HCV. From a broader perspective, there has been a revolution in HCV therapy with the recent rapid evolution of short-term (12 weeks) safe, all oral directly- acting antiviral (DAA) therapy leading to cure rates of 90% to 100%, even in previously difficult to treat patients with liver cirrhosis, previous treatment failure and those on immunosuppression...
January 2016: Annals of the Academy of Medicine, Singapore
N S Shalaka, N A Garred, H T Zeglam, S A Awasi, L A Abukathir, M E Altagdi, A A Rayes
In Libya, little is known about HIV-related hospitalizations and in-hospital mortality. This was a retrospective analysis of HIV-related hospitalizations at Tripoli Medical Centre in 2013. Of 227 cases analysed, 82.4% were males who were significantly older (40.0 versus 36.5 years), reported injection drug use (58.3% versus 0%) and were hepatitis C virus co-infected (65.8% versus 0%) compared with females. Severe immunosuppression was prevalent (median CD4 count = 42 cell/μL). Candidiasis was the most common diagnosis (26...
September 2015: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
Katia Jaira Galisteu, Luciana Ventura Cardoso, Adriana Antônia da Cruz Furini, Arlindo Schiesari Júnior, Claudia Bernardi Cesarino, Célia Franco, Andrea Regina de Souza Baptista, Ricardo Luiz Dantas Machado
INTRODUCTION: In this study, clinical-laboratory and epidemiological characteristics are described for a group of 700 individuals with HIV (human immunodeficiency virus)/AIDS (acquired immunodeficiency syndrome) in the ART (antiretroviral therapy) era at a teaching hospital that provides a quaternary level of care, with an emphasis on opportunistic infections (OIs), co-infections and immune profile. METHODS: A retrospective cross-sectional study of AIDS cases was conducted from 1998 to 2008 by reviewing medical records from the Base Hospital/FUNFARME (Fundação Faculdade Regional de Medicina), São José do Rio Preto, São Paulo, Brazil...
March 2015: Revista da Sociedade Brasileira de Medicina Tropical
C K Ojide, E I Kalu, E Ogbaini-Emevon, V U Nwadike
BACKGROUND: Hepatitis B and C viral co-infections with human immunodeficiency virus (HIV) are known to affect progression, management, and outcome of HIV infection. This study was aimed to access the prevalence of hepatitis B and C co-infections in HIV-infected adult patients in the University of Benin Teaching Hospital with a view of understanding the gravity of this problem in the local population. METHODS: The descriptive cross-sectional study was carried out on 342 HIV-infected adult patients on highly active antiretroviral therapy attending HIV Outpatients Clinic of University of Benin Teaching Hospital, between April and September, 2011...
July 2015: Nigerian Journal of Clinical Practice
Lc Ikeako, Hu Ezegwui, Lo Ajah, Cc Dim, Tc Okeke
BACKGROUND: Sexually transmitted infections and human immunodeficiency virus (HIV)/AIDS are a major public health concern owing to both their prevalence and propensity to affect offspring through vertical transmission. AIM: The aim was to determine the seroprevalence of HIV, hepatitis B virus (HBV), hepatitis C virus (HCV), syphilis, and co-infections among antenatal women in Enugu, South-East Nigeria. MATERIALS AND METHODS: A retrospective study of antenatal women at the University of Nigeria Teaching Hospital, Enugu, South-East Nigeria from 1(st) May 2006 to 30(th) April 2008...
November 2014: Annals of Medical and Health Sciences Research
Lc Ikeako, Hu Ezegwui, Lo Ajah, Cc Dim, Tc Okeke
BACKGROUND: Sexually transmitted infections and human immunodeficiency virus (HIV)/AIDS are a major public health concern owing to both their prevalence and propensity to affect offspring through vertical transmission. AIM: The aim was to determine the seroprevalence of HIV, hepatitis B virus (HBV), hepatitis C virus (HCV), syphilis, and co-infections among antenatal women in Enugu, South-East Nigeria. MATERIALS AND METHODS: A retrospective study of antenatal women at the University of Nigeria Teaching Hospital, Enugu, South-East Nigeria from May 1, 2006 to April 30, 2008...
September 2014: Annals of Medical and Health Sciences Research
José Medrano, Alejando Álvaro-Meca, Alexandre Boyer, María A Jiménez-Sousa, Salvador Resino
INTRODUCTION: The combination antiretroviral therapy (cART) has led to decreased opportunistic infections and hospital admissions in human immunodeficiency virus (HIV)-infected patients, but the intensive care unit (ICU) admission rate remains constant (or even increased in some instances) during the cART era. Hepatitis C virus (HCV) infection is associated with an increased risk for hospital admission and/or mortality (particularly those related to severe liver disease) compared with the general population...
2014: Critical Care: the Official Journal of the Critical Care Forum
Abdel-Nasser Elzouki, Salwa M Elgamay, Abdeulaziz Zorgani, Omer Elahmer
The aim of the present study was to determine the frequency of hepatitis B and C transmission to health care workers (HCWs) in five major hospitals in eastern Libya and to analyze how the risk of these infections are affected by the type of occupation, hospital work place and working period. From July 2008 to June 2009, 601 HCWs (mean age: 32.90 ± 8.85 years) were tested for HBV and HCV markers using ELISA techniques. Polymerase chain reaction (PCR) was performed on all positive samples of HBsAg and Anti-HCV antibody to determine the level of HBV-DNA and HCV-RNA viremia, respectively...
November 2014: Journal of Infection and Public Health
Maria Rosa Cantudo-Cuenca, Rocio Jiménez-Galán, Carmen V Almeida-Gonzalez, Ramón Morillo-Verdugo
BACKGROUND: The use of highly active antiretroviral therapy has significantly reduced morbidity and mortality, thus increasing life expectancy of human immunodeficiency virus (HIV)-infected individuals, transforming HIV into a chronic disease. Accordingly, there has been an increase in the number of comorbidities concomitantly present in these individuals and also an increased use of comedications, which may negatively impact antiretroviral therapy adherence. These factors can affect adherence to antiretroviral therapy...
August 2014: Journal of Managed Care & Specialty Pharmacy
D Dušková, L Darebníček
The Roche Cobas TaqScreen MPX Test v1 - multiplex reverse transcription-real time (MPX RT-Real Time) PCR, performed on Cobas s201 for HCV RNA, HBV DNA, HIV-1 RNA /group M and O/, and HIV-2 RNA was introduced as a supplement to the currently used imunoanalysis method for blood donor´s testing (Abbott CMIA - chemiluminescent microparticle imunoassay, performed on Architect i2000 for anti-HCV, hepatitis B surface antigen (HBsAg)), anti-HIV-1 /group M and O/, anti-HIV-2 and p24 HIV). The results of study could provide valuable arguments to support the discussion about the NAT implementation into the standards of blood donor´s testing in the Czech Republic...
2014: Acta Virologica
D Podzamczer, A Imaz, I Perez, P Viciana, E Valencia, J Curto, T Martín, M Castaño, J Rojas, N Espinosa, V Moreno, V Asensi, J A Iribarren, B Clotet, L Force, P Bachiller, H Knobel, J C López Bernaldo De Quirós, J R Blanco, N Rozas, J Vergas, A Ocampo, A Camacho, J Flores, J L Gomez-Sirvent
OBJECTIVES: To present clinical experience with a regimen including abacavir/lamivudine + darunavir/ritonavir in a cohort of HIV-1-infected patients. METHODS: A retrospective, multicentre cohort study, including all consecutive adult HIV-1-infected patients who started abacavir/lamivudine + darunavir/ritonavir from April 2008 to December 2010 and had at least one follow-up visit. The primary endpoint was HIV-1 viral load (VL) <40 copies/mL at week 48...
September 2014: Journal of Antimicrobial Chemotherapy
Chiekulie Kevin Diwe, Emmanuel Chidiebere Okwara, Oguamanam Okezie Enwere, Jerome Emeka Azike, Nathan Chibuzo Nwaimo
INTRODUCTION: Highly active antiretroviral therapy (HAART) has improved survival of human immunodeficiency virus (HIV) patients. Concurrent morbidities from liver diseases among these patients have also been observed due to co-infection with hepatitis B and C viruses (HBV and HCV). HAART reduces liver-associated morbidities and mortalities in such patients. Unfortunately free testing of HBV and HCV are not provided alongside free HIV testing and treatment in Nigeria. We assessed the seroprevalence of HBV and HCV among HIV patients presenting for treatment in our center...
2013: Pan African Medical Journal
Shivani Datta, Jeremy Horwood, Matthew Hickman, Debbie Sharp
BACKGROUND: Hepatitis C is often asymptomatic, presenting with liver failure and cancer decades after infection. People who inject drugs (PWID) and immigrant populations from countries with a moderate-to-high prevalence of hepatitis C virus (HCV) are the main risk groups. Deaths and hospital admissions due to HCV cirrhosis tripled between 1998 and 2010, but the majority of people with chronic HCV are unaware of it. AIM: To identify patients at risk of developing hepatitis C using routine GP data, to determine the proportion not tested, and to explore GPs' views regarding testing...
February 2014: British Journal of General Practice: the Journal of the Royal College of General Practitioners
Ryan McNeil, Will Small, Evan Wood, Thomas Kerr
People who inject drugs (PWID) experience high levels of HIV/AIDS and hepatitis C (HCV) infection that, together with injection-related complications such as non-fatal overdose and injection-related infections, lead to frequent hospitalizations. However, injection drug-using populations are among those most likely to be discharged from hospital against medical advice, which significantly increases their likelihood of hospital readmission, longer overall hospital stays, and death. In spite of this, little research has been undertaken examining how social-structural forces operating within hospital settings shape the experiences of PWID in receiving care in hospitals and contribute to discharges against medical advice...
March 2014: Social Science & Medicine
Ziqiang Zhu, Teena Dhir, Myat Soe, Linda Green, Ning Jiang
Summary Due to the shared risk factors for viral transmission, coinfection of human immunodeficiency virus (HIV) and hepatitis C virus (HCV) is common. This study examined the seroprevalence of HCV among HIV-infected patients in inpatient and outpatient settings. A retrospective chart review of 256 HIV-infected patients was conducted in Prince George's Hospital Center (inpatients from 1 September 2011 to 1 March 2012) and Glenridge Medical Center (outpatients from 1 January 2011 to 31 December 2012). The mean age of the population was 46 ± 12 and 44 ± 11 for inpatients and outpatients, respectively...
October 2014: International Journal of STD & AIDS
Harsh Chalana, Harjot Singh, Jasmine Kaur Sachdeva, Shivangi Sharma
Substance dependents often seek help for deaddiction and are detected positive during routine viral markers testing. We screened such patients in our hospital ShriGuru RamDas Institute of Medical Sciences and Research (SGRDIMSR) which is situated in a rural area adjoining the city of Amritsar; being a tertiary care centre it caters to a large population. A total of 1382 patients were admitted to the psychiatry ward from 01 July 2009 to 31 December 2012 and screened for study, out of whom 4.63% (n=64) refused to consent for participation in the study...
December 2013: Asian Journal of Psychiatry
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