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C L Romano', E Gallazzi, N Logoluso, E De Vecchi, L Drago
Bone and joint infections are a difficult to treat condition, often associated with bone loss. Although the management of septic bone defects may currently be achieved through various treatment modalities, there is a continuous need for bone substitutes able at the same time to favour bone repair and to provide local antibacterial protection. RegenOss, a biomimetic and resorbable bone substitute, has been previously shown to be highly biocompatible and osteoconductive. Aims of the present study were to test the in vitro ability of RegenOss to act as a local carrier of antibiotics and to investigate its clinical safety and efficacy in a continuous series of patients, affected by bone loss in active or previous infection...
October 2015: Journal of Biological Regulators and Homeostatic Agents
Nancy Bidone, Norberto Giglio, Julia Bakir, María G Sheehan, María P Arias López, Melina Rosin, Julio Farías, Adriana Procopio, Angela Gentile
INTRODUCTION: Antibiotics are the most prescribed drugs in pediatric intensive care units (PICU) with high impact in pathogens resistance and costs. OBJECTIVES: Evaluate prescription patterns and consumption of antibiotics. MATERIALS AND METHODS: From July 2006 to January 2007, monthly cross-sectional cuts were done on antibiotics use at the 1st and 7th days of prescription. A monthly antibiotics consumption average was then calculated. RESULTS: Of 81 patients, 41 received antibiotics, of which 34 were treated for at least seven days...
October 2008: Archivos Argentinos de Pediatría
E Vilalta Castel, M S Alcázar Montero, C Navarro Gaspar, M Gimeno Aranguez
A case of nosocomial diarrhea by Clostridium difficile in an older woman with an old history of increasing stool frequency, is reported. Colonoscopy and biopsy was performed due to an incomplete response to vancomicyn, and the diagnosis of underlying ulcerative colitis was made. The incidence of Clostridium difficile infection associated with the relapse of ulcerative colitis is nearly 10%. In patients with ulcerative colitis, macroscopic pseudomembranes and the usual predisposing factors for Clostridium difficile infection, usually, are not present...
December 2002: Anales de Medicina Interna: Organo Oficial de la Sociedad Española de Medicina Interna
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