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Uterine Leiomyomas

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https://www.readbyqxmd.com/read/29642801/regulation-of-cell-cycle-regulatory-proteins-by-micrornas-in-uterine-leiomyoma
#1
Tsai-Der Chuang, Omid Khorram
The objective of this study was to determine whether miR-93, miR-29c, and miR-200c, which we previously reported to be downregulated in leiomyomas, target cell cycle regulatory proteins that influence cell proliferation. Based on TargetScan algorithm 3 cell cycle regulatory proteins namely, E2F transcription factor 1 (E2F1), Cyclin D1 (CCND1) and CDK2 which were predicted to be targets of these miRNAs were  further analyzed. In 30 hysterectomy specimens, we found the expression of E2F1 and CCND1 messenger RNA (mRNA) was increased in leiomyoma as compared to matched myometrium, with no significant changes in CDK2 mRNA levels...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29629977/clinicopathologic-features-and-genetic-alterations-of-a-primary-osteosarcoma-of-the-uterine-corpus
#2
Gang Zheng, Abby Richmond, Chengbao Liu, Alexander Berrebi, Aparna Pallavajjala, Lisa Haley, Rebecca L Stone, Edward McCarthy, Russell Vang, Deyin Xing
Primary osteosarcoma (OS) of the uterus is distinctly rare. We report a case of primary uterine OS with pulmonary metastasis in a 74-yr-old woman. Histopathologic features of the uterine tumor were in keeping with a pure chondroblastic OS composed of neoplastic cells with osteoblastic/chondroblastic differentiation and neoplastic bone formation. Despite treatment with Doxorubicin and Olaratumab and later with palliative radiation therapy, the patient died 7 mo after hysterectomy due to multiple distant metastases...
April 6, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29628616/updates-on-uterine-artery-embolization
#3
REVIEW
Maureen P Kohi, James B Spies
Uterine fibroids (leiomyomas) are the most common benign neoplasm of the female pelvis and have a lifetime prevalence exceeding 80% among African American women and approaching 70% among Caucasian women. Approximately 50% of women with fibroids experience symptoms which may include menorrhagia that may result in anemia, bulk symptoms with bladder and bowel dysfunction and abdominal protrusion, dysmenorrhea, and infertility. Hysterectomy remains the most common treatment option for fibroids and concerns have been raised about the overuse of this procedure...
March 2018: Seminars in Interventional Radiology
https://www.readbyqxmd.com/read/29625536/weight-change-and-risk-of-uterine-leiomyomas-korea-nurses-health-study
#4
Ji-Eun Lee, Sihan Song, Eunyoung Cho, Hee Jung Jang, Heeja Jung, Hea-Young Lee, Sue Kim, Oksoo Kim, Jung Eun Lee
OBJECTIVE: We examined the associations between anthropometric measures and uterine leiomyomas. METHODS: We included a total of 5,062 women (median age of 35.5 years) who had experienced pregnancy and, of these women, 210 reported a diagnosis of uterine leiomyomas within the past 2 years in the Korea Nurses' Health Study. Participants were asked about their anthropometric factors. We calculated odds ratios (ORs) and 95% confidence intervals (95% CIs) using logistic regression models...
April 6, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29620641/expression-and-prognostic-value-of-lactate-dehydrogenase-a-and-d-subunits-in-human-uterine-myoma-and-uterine-sarcoma
#5
Ke-Juan Song, Xiao-Ni Yu, Teng Lv, Yu-Long Chen, Yu-Chao Diao, Su-Li Liu, Yan-Kui Wang, Qin Yao
OBJECTIVE: This study aimed to determine the expression of lactate dehydrogenase (LDH)-A and LDH-D in patients with uterine myoma, cellular leiomyoma (CLM), and uterine sarcoma and to evaluate their prognostic significance. METHODS: Protein expression levels of LDH-A and LDH-D were determined in tissue samples from 86 patients (26 uterine myoma, 10 CLM, 50 uterine sarcoma) by immunohistochemistry and their associations with clinicopathologic parameters and outcomes were analyzed in patients with uterine sarcoma...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29607236/a-case-of-primary-uterina-lymphoma-presenting-with-bleeding-pelvic-pain-and-dysmenorrhea
#6
Lilian Yukari Miura, Miriam Anyury Daquin Maure, Monica Tessmann Zomer, Reitan Ribeiro, Teresa Cristina Santos Cavalcanti, William Kondo
Primary non-Hodgkin's lymphoma (NHL) can arise from lymphatic cells located in solid organs (extranodal) and it accounts for 25 to 35% of all NHL. Primary lymphoma on the female genital tract (PLFGT) is a rare disease, comprising 0.2 to 1.1% of all extranodal lymphomas in the female population. In this paper, the authors report an extremely rare case of a 48-year-old woman who exhibited an abnormal uterine bleeding, pelvic pain, and dysmenorrhea history. The transvaginal ultrasound showed an anteverted uterus measuring 153 cm3 in volume, with intramural leiomyomas...
2018: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29604475/robotic-assisted-laparoscopic-cervicovaginal-myomectomy
#7
Pouya Javadian, Alexander Juusela, Farr Nezhat
STUDY OBJECTIVE: To illustrate a robotic assisted laparoscopic resection for the cervicovaginal myomectomy. DESIGN: Step-wise instruction using video. Case report (Canadian Task Force classification III). SETTING: A tertiary referral center in New York, NY, USA. A 39-year-old woman G0, (body mass index of 23.0 kg/m2 ) with known cervicovaginal fibroid which in the past underwent uterine artery embolization, presented with recurrence of her severe abnormal vaginal bleeding...
March 28, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29602142/predictive-factor-for-volume-reduction-of-uterine-fibroids-after-short-term-use-of-ulipristal-acetate
#8
Bo Seong Yun, Seok Ju Seong, Yong Wook Jung, Mi-La Kim, Hyo Sook Bae, Mi Kyoung Kim, Sung Shin Shim
OBJECTIVES: Ulipristal acetate (UPA) is a selective progesterone receptor modulator, which has been used to treat uterine fibroids. Many published reports about the outcomes indicate effective control of bleeding and reduction in the fibroid volume following both short- and long-term therapy. However, the reported volume reduction varies across different reports. Therefore, the purpose of this study was to investigate the factors that can affect the volume reduction of uterine fibroids, after short-term UPA therapy in patients with symptomatic uterine fibroids...
March 17, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29593997/hereditary-leiomyomatosis-and-renal-cell-cancer-cutaneous-lesions-atypical-fibroids
#9
Pietro Bortoletto, Jennifer L Lindsey, Liping Yuan, Bradley J Quade, Antonio R Gargiulo, Cynthia C Morton, Elizabeth A Stewart, Raymond M Anchan
Objective: To report a diagnosis of hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome following initial presentation with multiple cutaneous lesions. Design: Case report. Design classification: N/A. Setting: Academic tertiary care center. Patients: 27-year-old nulligravid woman who presented with multiple red-brown lesions on her skin found to have cutaneous and uterine leiomyoma...
July 2017: Case Reports in Women's Health
https://www.readbyqxmd.com/read/29578184/uterine-metastases-originating-from-a-pulmonary-inflammatory-myofibroblastic-tumor
#10
Jun Zhang, Yuehong Li, Lei Lou
Pulmonary inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor, and is considered an inflammatory pseudotumor. Here, we report of a 37-year-old woman with severe cough and stridor who was diagnosed with primary IMT of the lungs, with adenocarcinoma in situ based on the pathology in December 2012. A year later, transabdominal ultrasonography demonstrated a solid mass in the uterine wall that was initially diagnosed as a leiomyoma. However, postoperative histological examination and immunohistochemical staining revealed it as a uterine metastasis of the lung IMT...
2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29577850/a-statistical-approach-to-detect-intrinsically-disordered-proteins-associated-with-uterine-leiomyoma
#11
Ujjwal Maulik, Sagnik Sen
BACKGROUND: Uterine Leiomyoma is mainly widespread non-malignant tumor. Around more than 80% woman have these particular tumor among them only 30% of them are detected. Integrin-ᵦ1 is one of the up regulated biomarkers during tumorgenesis which is also associated with structural disordered. Intrinsically disordered proteins are one of the types which are dealing with unstructuredness especially in tertiary structural orchestration. Around 30% of the human proteins consist of intrinsically disordered regions...
March 25, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29574773/omega-3-fatty-acids-modulate-the-lipid-profile-membrane-architecture-and-gene-expression-of-leiomyoma-cells
#12
Md Soriful Islam, Clara Castellucci, Rosamaria Fiorini, Stefania Greco, Riccardo Gagliardi, Alessandro Zannotti, Stefano R Giannubilo, Andrea Ciavattini, Natale G Frega, Deborah Pacetti, Pasquapina Ciarmela
Uterine leiomyomas (fibroids or myomas) are the most common benign tumors of premenopausal women and new medical treatments are needed. This study aimed to determine the effects of omega-3 fatty acids on the lipid profile, membrane architecture and gene expression patterns of extracellular matrix components (collagen1A1, fibronectin, versican, or activin A), mechanical signaling (integrin β1, FAK, and AKAP13), sterol regulatory molecules (ABCG1, ABCA1, CAV1, and SREBF2), and mitochondrial enzyme (CYP11A1) in myometrial and leiomyoma cells...
March 25, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29569640/comment-on-delayed-intestinal-perforation-and-vertebral-osteomyelitis-after-high-intensity-focused-ultrasound-treatment-for-uterine-leiomyoma
#13
COMMENT
Jennifer K Y Ko, Vincent Y T Cheung
No abstract text is available yet for this article.
March 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29568968/screening-of-potential-biomarkers-in-uterine-leiomyomas-disease-via-gene-expression-profiling-analysis
#14
Xuhui Liu, Yanfei Liu, Jingrong Zhao, Yan Liu
The present study aimed to screen potential biomarkers for uterine leiomyomas disease, particularly target genes associated with the mediator of RNA polymerase II transcription subunit 12 (MED12) mutation. The microarray data of GSE30673, including 10 MED12 wild-type myometrium, 8 MED12 mutation leiomyoma and 2 MED12 wild-type leiomyoma samples, were downloaded from the Gene Expression Omnibus database. Compared with myometrium samples, differently-expressed genes (DEGs) in the MED12 mutation and wild-type leiomyoma samples were identified using the Limma package...
March 15, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29564312/effectiveness-and-safety-of-sublingual-misoprostol-in-medical-treatment-of-the-1st-trimester-miscarriage-experience-of-off-label-use-in-korea
#15
Jung Yeon Park, Hyo Jeong Ahn, Ba Raem Yoo, Kyu Ri Hwang, Taek Sang Lee, Hye Won Jeon, Sun Min Kim, Byoung Jae Kim
Objective: This study was conducted to determine the effectiveness and safety of medical treatment with sublingual misoprostol (MS) in the 1st trimester miscarriage under the approval by Health Insurance Review and Assessment Service (HIRA) for off-label usage by the single medical center in Korea. Methods: A retrospective cohort study was performed in one institution between April 2013 and June 2016. Ninety-one patients diagnosed with miscarriage before 14 weeks of gestation and wanted to try medical treatment were included...
March 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29564309/current-medical-treatment-of-uterine-fibroids
#16
REVIEW
Geum Seon Sohn, SiHyun Cho, Yong Man Kim, Chi-Heum Cho, Mee-Ran Kim, Sa Ra Lee
Uterine fibroids (leiomyomas or myomas), benign monoclonal tumors, are the most common benign tumors in women. Heavy or prolonged menstrual bleeding, abnormal uterine bleeding, resultant anemia, pelvic pain, infertility, and/or recurrent pregnancy loss are generally associated with uterine fibroids. Although curative treatment of this tumor relies on surgical therapies, medical treatments are considered the first-line treatment to preserve fertility and avoid or delay surgery. The aim of this review is to provide available and emerging medical treatment options for symptomatic uterine fibroids...
March 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29550681/recurrent-benign-leiomyomas-after-total-abdominal-hysterectomy-rich-or-poor-estrogenic-environment-may-lead-to-their-recurrence
#17
Konstantinos Kyriakopoulos, Ekaterini Domali, Sofoklis Stavrou, Alexandros Rodolakis, Dimitrios Loutradis, Peter Drakakis
INTRODUCTION: Benign metastasizing leiomyomas represent benign lesions consisted by leiomatosous tissue and could be observed in positions away from their usual localization, the human uterus. They commonly affect women that have undergone total hysterectomy. Approximately 100 similar cases have been reported in the literature, so the case we present is rare and reviewing the literature and needs to be reported. PRESENTATION OF CASE: We report a case of a 55 year old Greek woman, gravida five and para three, who attended our unit 3 years ago complaining of occasionally lower abdominal pain and irritation the last months...
February 22, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29547053/explorative-investigation-of-whole-lesion-histogram-mri-metrics-for-differentiating-uterine-leiomyomas-and-leiomyosarcomas
#18
Luke Gerges, Dorota Popiolek, Andrew B Rosenkrantz
OBJECTIVE: The purpose of this study is to assess the utility of texture analysis of multiple MRI sequences for the differentiation of uterine leiomyomas and leiomyosarcomas. MATERIALS AND METHODS: Seventeen leiomyosarcomas and 51 leiomyomas undergoing MRI before resection were included. Whole-lesion volumes of interest were placed on T2-weighted images, contrast-enhanced T1-weighted images, and apparent diffusion coefficient (ADC) maps. The diagnostic performance of histogram metrics was assessed...
March 16, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29538195/one-stage-surgery-for-removal-of-intravascular-leiomyomatosis-extending-to-right-ventricle
#19
Ching-Shu Chiang, Po-Lin Chen, Tzu-Ting Kuo, I-Ming Chen, Nai-Yuan Wu, Hsiao-Huang Chang
RATIONALE: Intravascular leiomyomatosis (IVL) is a rare nonmalignant tumor that can be fatal if untreated. PATIENT CONCERNS: A 49-year-old nulliparous Asian woman who underwent hysterectomy and left salpingo-oophorectomy for multiple uterine leiomyomas 18 months prior presented complaining of intermittent palpitation and chest tightness for approximately 1 month. Echocardiography revealed a large mobile tumor mass extending from the inferior vena cava (IVC) to the right atrium that partially obstructed IVC flow and tricuspid inflow...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29533153/the-relationship-between-female-reproductive-functions-and-vitamin-d
#20
Sabriye Arslan, Yasemin Akdevelioğlu
Nonclassical target organs recently defined for vitamin D, a major regulator of calcium phosphorus homeostasis and bone health, include reproductive ones. This compilation study focuses on the potential effects of vitamin D on female reproductive functions. Vitamin D receptor enzymes that metabolize vitamin D are expressed in both central and peripheral reproductive organs. Most studies suggest that vitamin D may be directly or indirectly related to gonadal functions. Vitamin D's effects on reproductive functions may be indirectly related to diseases such as polycystic ovary syndrome (PCOS), uterine leiomyomas, and endometriosis...
March 13, 2018: Journal of the American College of Nutrition
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