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Uterine Leiomyomas

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https://www.readbyqxmd.com/read/27921159/differentiation-of-uterine-leiomyosarcoma-from-atypical-leiomyoma-diagnostic-accuracy-of-qualitative-mr-imaging-features-and-feasibility-of-texture-analysis
#1
Yulia Lakhman, Harini Veeraraghavan, Joshua Chaim, Diana Feier, Debra A Goldman, Chaya S Moskowitz, Stephanie Nougaret, Ramon E Sosa, Hebert Alberto Vargas, Robert A Soslow, Nadeem R Abu-Rustum, Hedvig Hricak, Evis Sala
PURPOSE: To investigate whether qualitative magnetic resonance (MR) features can distinguish leiomyosarcoma (LMS) from atypical leiomyoma (ALM) and assess the feasibility of texture analysis (TA). METHODS: This retrospective study included 41 women (ALM = 22, LMS = 19) imaged with MRI prior to surgery. Two readers (R1, R2) evaluated each lesion for qualitative MR features. Associations between MR features and LMS were evaluated with Fisher's exact test. Accuracy measures were calculated for the four most significant features...
December 5, 2016: European Radiology
https://www.readbyqxmd.com/read/27898669/postoperative-quality-of-life-and-sexual-function-in-premenopausal-women-undergoing-laparoscopic-myomectomy-for-symptomatic-fibroids-a-prospective-observational-cohort-study
#2
Julia Caroline Radosa, Christoph Georg Radosa, Russalina Mavrova, Stefan Wagenpfeil, Amr Hamza, Ralf Joukhadar, Sascha Baum, Maria Karsten, Ingolf Juhasz-Boess, Erich-Franz Solomayer, Marc Philipp Radosa
INTRODUCTION: Uterine leiomyomas are the most common benign gynecologic tumors. To date laparoscopy myomectomy is the gold standard for treatment of symptomatic fibroids in reproductive-aged women. Detailed counseling about the effects of this procedure on postoperative sexuality and quality of life is important in these patients. However, available data on these subjects are limited and contradictory. The aim of this study was to assess sexual function and quality of life in premenopausal women undergoing laparoscopic myomectomy for symptomatic uterine fibroids...
2016: PloS One
https://www.readbyqxmd.com/read/27898339/dietary-phytochemicals-for-possible-preventive-and-therapeutic-option-of-uterine-fibroids-signaling-pathways-as-target
#3
REVIEW
Md Soriful Islam, James H Segars, Mario Castellucci, Pasquapina Ciarmela
A growing interest has emerged on dietary phytochemicals to control diverse pathological conditions. Unfortunately, dietary phytochemical research in uterine fibroids is still under construction. Uterine fibroids/leiomyomas are benign tumors developing from the myometrium of the uterus in premenopausal women. They may occur in more than 70% of women, and approximately 25% of women show clinically significant symptoms. These include heavy and prolonged menstrual bleeding, pelvic pressure (urinary frequency, incontinence, and difficulty with urination), pelvic pain, pelvic mass, infertility, and reproductive dysfunction...
October 20, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/27895695/the-effects-of-guizhi-fuling-capsule-drug-serum-on-uterine-leiomyoma-cells-and-its-mechanism
#4
Qi Shen, Weijing Ye, Xiaoli Hu, Chuchu Zhao, Lulu Zhou, Xueqiong Zhu
Aims. To observe the effects of Guizhi Fuling Capsule (GZFLC) drug serum on uterine leiomyoma cells and explore its mechanism. Main Methods. Sixty Sprague Dawley rats were randomly divided into two groups (normal saline lavage group and GZFLC lavage group), then, respectively, blank serum and GZFLC drug serum were collected, and finally human uterine leiomyoma cells were treated. Human leiomyoma tissues were collected from 20 patients who underwent uterine leiomyomas operations, and leiomyoma cells were primary cultured...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27889101/highly-heterogeneous-genomic-landscape-of-uterine-leiomyomas-by%C3%A2-whole-exome-sequencing-and-genome-wide-arrays
#5
Svetlana A Yatsenko, Priya Mittal, Michelle A Wood-Trageser, Mirka W Jones, Urvashi Surti, Robert P Edwards, Anil K Sood, Aleksandar Rajkovic
OBJECTIVE: To determine the genomic signatures of human uterine leiomyomas and prevalence of MED12 mutations in human uterine leiomyosarcomas. DESIGN: Retrospective cohort study. SETTING: Not applicable. PATIENT(S): This study included a set of 16 fresh frozen leiomyoma and corresponding unaffected myometrium specimens as well as 153 leiomyosarcomas collected from women diagnosed with uterine leiomyomas or leiomyosarcomas who underwent clinically indicated abdominal hysterectomy...
November 23, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27885348/should-prophylactic-anticoagulation-be-considered-with-large-uterine-leiomyoma-a-case-series-and-literature-review
#6
Mohamed A Satti, Carmen Paredes Saenz, Rubin Raju, Sierra Cuthpert, Abed Kanzy, Sina Abhari, John Hebert Iii, Frederico G Rocha
Introduction. Uterine leiomyomas, also called uterine fibroids or myomas, are the most common pelvic tumors in women. They are very rarely the cause of acute complications. However, when complications occur they cause significant morbidity and mortality. Thromboembolic disease has been described as a rare complication of uterine leiomyomas. DVT is a serious illness, sometimes causing death due to acute PE. Cases. We report a case series of 3 patients with thromboembolic disease associated with uterine leiomyoma at Hurley Medical Center, Flint, Michigan, during 2015 and conduct a literature review on the topic...
2016: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27884686/intraarterial-lidocaine-for-pain-control-in-uterine-artery-embolization-a-prospective-randomized-study
#7
Maxime Noel-Lamy, Kong T Tan, Martin E Simons, Kenneth W Sniderman, Oleg Mironov, Dheeraj K Rajan
PURPOSE: To assess efficacy of two different techniques of lidocaine injection in the uterine arteries to reduce pain following uterine artery embolization (UAE) for leiomyomas. MATERIALS AND METHODS: This prospective randomized single-blinded study was performed with 60 patients enrolled between November 2014 and December 2015 equally randomized to 3 arms. Group A received 10 mL lidocaine 1% (100 mg) mixed with polyvinyl alcohol particles (355-500 μm). Group B received the same dose of lidocaine injected after embolization...
November 21, 2016: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/27882238/large-uterine-pyomyoma-in-a-perimenopausal-female-a-case-report-and-review-of-50-reported-cases-in-the-literature
#8
Naoyuki Iwahashi, Yasushi Mabuchi, Michihisa Shiro, Shigetaka Yagi, Sawako Minami, Kazuhiko Ino
Pyomyoma is a rare complication, which withoug antibiotics or surgical intervention, may cause sepsis and mortality. The present study reported a case of large uterine pyomyoma in a perimenopausal female. A 53-year-old multigravida woman was referred to the Department of Obstetrics and Gynecology (Wakayama Medical University, Wakayama, Japan) due to progressive abdominal distension. The patient presented with anemia gravis, severe inflammatory reaction and cachexia. Computed tomography revealed a large unilocular mass, 50 cm in size, with an irregular surface and thickened wall, occupying the entire abdomen...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27875759/round-ligament-leiomyoma-a-rare-manifestation-of-a-common-entity
#9
Madhvi Deol, Elizabeth Kagan Arleo
A 68-year-old woman with a history of multifocal uterine leiomyomas presented with left groin pain and was referred for cross-sectional imaging to assess for the presence of an inguinal hernia. In this patient, MRI demonstrated a round ligament leiomyoma encased in the proximal left inguinal canal. Leiomyomas are the most common benign gynecologic tumors, however round ligament leiomyomas are very rare. The purpose of this case report is to highlight a rare manifestation of a common entity.
November 5, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27871850/er%C3%AE-inhibited-myocardin-induced-differentiation-in-uterine-fibroids
#10
Xing-Hua Liao, Jun-Yan Li, Xiu-Mei Dong, Xiuhong Wang, Yuan Xiang, Hui Li, Cheng-Xi Yu, Jia-Peng Li, Bai-Yin Yuan, Jun Zhou, Tong-Cun Zhang
Uterine fibroids, also known as uterine leiomyomas, are a benign tumor of the human uterus and the commonest estrogen-dependent benign tumor found in women. Myocardin is an important transcriptional regulator in smooth and cardiac muscle development. The role of myocardin and its relationship with ERα in uterine fibroids have barely been addressed. We noticed that the expression of myocardin was markedly reduced in human uterine fibroid tissue compared with corresponding normal or adjacent myometrium tissue...
November 19, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/27864989/the-mitosis-specific-marker-phosphohistone-h3-phh3-is-an-independent-prognosticator-in-uterine-smooth-muscle-tumors-an-outcome-based-study
#11
Kin-Long Chow, Ka-Yu Tse, Ching-Lung Cheung, Ka-Wing Wong, Annie N Y Cheung, Richard W C Wong, Alice N H Chan, Nancy W F Yuen, Hextan Y S Ngan, Philip P C Ip
: Accurate mitosis-counting, which is important in the diagnosis of uterine smooth muscle tumors (USMT), is often difficult and subjective. The mitosis-specific immunohistochemical marker phosphohistone H3 (PHH3) has been shown to be diagnostically useful but its expression, in relation to outcome, has not been thoroughly investigated. AIMS AND METHODS: PHH3 expression was evaluated on 55 leiomyosarcomas (LMSs), 26 smooth muscle tumors of uncertain malignant potential (STUMPs), 18 leiomyomas with bizarre nuclei (LBNs) and 12 leiomyomas (LMs)...
November 16, 2016: Histopathology
https://www.readbyqxmd.com/read/27862503/accuracy-of-saline-contrast-sonohysterography-in-detection-of-endometrial-polyps-and-submucosal-leiomyoma-in-women-at-reproductive-age-with-abnormal-uterine-bleeding-a-systematic-review-and-meta-analysis
#12
REVIEW
Carolina Abdou Bittencourt, Ricardo Dos Santos Simões, Wanderley Marques Bernardo, Luiz Fernando Portugal Fuchs, José Maria Soares Junior, Ayrton Roberto Pastore, Edmund Chada Baracat
OBJECTIVE: To analyze the diagnostic accuracy of 2D and 3D saline contrast sonohysterography compared to hysteroscopy in the detection of endometrial polyps and submucosal myomas in women during reproductive age with abnormal uterine bleeding. METHOD: A systematic review of diagnostic studies that compared saline contrast sonohysterography with hysteroscopy was conducted according to the PRISMA and SEDATE recommendations. Only studies that compared two and/or three dimensional saline contrast sonohysterography with hysteroscopy and anatomopathology were included...
November 15, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27861360/association-between-uterine-leiomyoma-and-metabolic-syndrome-in-parous-premenopausal-women-a-case-control-study
#13
Young Jin Tak, Sang Yeoup Lee, Sun Ki Park, Yun Jin Kim, Jeong Gyu Lee, Dong Wook Jeong, Seung Chul Kim, In Joo Kim, Yu Hyun Yi
Previous studies have reported that uterine leiomyoma (UL) may share pathogenic features with obesity and hypertension, which are components of metabolic syndrome (MetS). We examined the association between UL and MetS in premenopausal parous women.This 1:1 case-control study was conducted on 615 asymptomatic women with UL and 615 women without UL that were matched for age, reproductive history, and hormonal use, who underwent a comprehensive health examination. UL was diagnosed by a gynecologist based on transvaginal ultrasonography findings...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27859319/uterine-angioleiomyoma-in-an-african-green-monkey-chlorocebus-aethiops-sabaeus
#14
Matthew John Valentine, Amy Beierschmitt, Josepha DeLay, John Joseph Callanan
BACKGROUND: A uterine neoplasm was observed, as an incidental finding, during post-mortem examination of a 26-year-old female multiparous African green monkey (Chlorocebus aethiops sabaeus). The intramural, expansile, 2 to 3 cm well-demarcated, dark-red, nodular neoplasm was located on the anterior uterine body (corpus) wall. METHODS: The mass was examined by light microscopy and by immunohistochemistry. RESULTS: The mass was confirmed as a cavernous uterine angioleiomyoma (syn...
November 8, 2016: Journal of Medical Primatology
https://www.readbyqxmd.com/read/27858913/laparoscopic-management-of-a-twisted-ovarian-leiomyoma-in-a-woman-with-10-weeks-gestation-case-report-and-literature-review
#15
Myounghwan Kim
BACKGROUND: Primary leiomyoma of the ovary is a rare benign ovarian tumor that only seldom causes acute abdomen. CASE SUMMARY: A 35-year-old gravida 1, para 0 woman presented with a history of acute lower abdominal pain, and 10 weeks of amenorrhea. The patient's physical examination revealed abdominal tenderness, defense, and rebound. On ultrasonographic examination, a solid mass measuring 9.3 × 7.8 cm was detected adjacent to the uterine fundus. The mass was preoperatively diagnosed as a twisted pedunculated subserosal uterine myoma...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27847869/dysfunctional-mnsod-leads-to-redox-dysregulation-and-activation-of-prosurvival-akt-signaling-in-uterine-leiomyomas
#16
Vania Vidimar, David Gius, Debabrata Chakravarti, Serdar E Bulun, Jian-Jun Wei, J Julie Kim
AKT signaling promotes cell growth and survival and is often dysregulated via multiple mechanisms in different types of cancer, including uterine leiomyomas (ULMs). ULMs are highly prevalent fibrotic tumors that arise from the smooth muscular layer of the uterus, the myometrium (MM). ULMs pose a major public health issue because they can cause severe morbidity and poor pregnancy outcomes. ‬We investigate the mechanisms driving ULM growth and survival via aberrant activation of AKT. We demonstrate that an acetylation-mediated impairment of the manganese superoxide dismutase (MnSOD) activity is prevalent in ULM cells compared to the normal-matched MM from the same patients...
November 2016: Science Advances
https://www.readbyqxmd.com/read/27846844/a-rare-case-with-synchronous-gastric-gastrointestinal-stromal-tumor-pancreatic-neuroendocrine-tumor-and-uterine-leiomyoma
#17
Elena Arabadzhieva, Atanas Yonkov, Sasho Bonev, Dimitar Bulanov, Ivanka Taneva, Alexandrina Vlahova, Tihomir Dikov, Violeta Dimitrova
BACKGROUND: Although gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract, they comprise less than 1% of all gastrointestinal tumors. Neuroendocrine tumors (NET) of the gastro-enteropancreatic system are also rare, representing about 2% of all gastrointestinal neoplasms. Pancreatic localization of NET is extremely uncommon-these tumors are only 1-5% of all pancreatic cancers. CASE PRESENTATION: We describe an unusual case with triple tumor localization-a gastric tumor, a formation in the pancreas, which involves the retroperitoneal space, and a uterine leiomyoma...
November 15, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27844480/the-association-between-uterine-leiomyoma-and-placenta-abruption-a-meta-analysis
#18
Ensiyeh Jenabi, Samira Ebrahimzadeh Zagami
BACKGROUND: some epidemiological studies have found that uterine leiomyoma can increase the risk of placenta abruption. To date, the meta-analysis has not been performed for assessing the relationship between uterine leiomyoma and placenta abruption. This meta-analysis was conducted to estimate the association between uterine leiomyoma and the risk of placenta abruption. METHODS: A literature search was conducted out in major databases PubMed, Web of Science, and Scopus from the earliest possible year to October 2016...
November 15, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27843659/rare-case-of-leiomyoma-and-adenomyosis-in-mayer-rokitansky-kuster-hauser-syndrome
#19
P S Hoo, A R Norhaslinda, J N Shah Reza
We report a case of adenomyosis which developed from a hypoplastic uterus and leiomyoma in a patient with MRKH syndrome. A 45-year-old Malay female with primary amenorrhoea and primary infertility presented with abdominal mass and abdominal pain. She is phenotypically female, has well developed secondary sexual characteristics, and has normal female external genitalia with shallow vagina dimple. Transabdominal ultrasonography showed a homogenous adnexal mass of 10 × 8 cm, uterus sized 5 × 4 cm, and normal kidneys...
2016: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27832674/uterine-fibroid-symptom-quality-of-life-questionnaire-translation-and-validation-into-brazilian-portuguese
#20
Rita Oliveira da Silva, Mariano Tamura Vieira Gomes, Rodrigo de Aquino Castro, Cláudio Emílio Bonduki, Manoel João Batista Castello Girão
Purpose To translate into Portuguese, culturally adapt and validate the Uterine Fibroid Symptom - Quality of Life (UFS-QoL) questionnaire for Brazilian women with uterine leiomyoma. Methods Initially, the UFS-QoL questionnaire was translated into Brazilian Portuguese in accordance with international standards, with subsequent cultural, structural, conceptual and semantic adaptations, so that patients were able to properly answer the questionnaire. Fifty patients with uterine leiomyoma and 19 patients without the disease, confirmed by abdominal pelvic examination and/or transvaginal ultrasound, were selected at the outpatient clinics of the Department of Gynecology of the Universidade Federal de São Paulo (Unifesp)...
October 2016: Revista Brasileira de Ginecologia e Obstetrícia
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