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Uterine Leiomyomas

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https://www.readbyqxmd.com/read/28521489/identification-of-proteins-with-different-abundance-associated-with-cell-migration-and-proliferation-in-leiomyoma-interstitial-fluid-by-proteomics
#1
Blendi Ura, Federica Scrimin, Cinzia Franchin, Giorgio Arrigoni, Danilo Licastro, Lorenzo Monasta, Giuseppe Ricci
Uterine leiomyoma is the most common female reproductive tract benign tumor. Little is known about protein composition and changes in the leiomyoma interstitial fluid (IF). The present study focused on changes in protein abundance in the IF of leiomyoma. Leiomyoma IFs and adjacent myometrial IFs were obtained and analyzed by two-dimensional electrophoresis (2-DE) coupled with mass spectrometry and western blotting for 2-DE data validation. A total of 25 unique proteins were observed to change significantly (P<0...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28511460/cuff-closure-by-vaginal-route-in-tlh-case-series-and-review-of-literature
#2
Huseyin Aydogmus, Serpil Aydoğmuş, Servet Gençdal, Sefa Kelekçi
Total Laparoscopic Hysterectomy (TLH) represents one of the most performed gynaecological procedures nowadays. The closure of the vaginal cuff is the most diffucult part of TLH because of the difficulty of laparoscopic suturing techniques. Our aim was to evaluate the efficacy and safety of vaginal cuff closure by vaginal route on patients submitted to TLH. During the period between January 2013 to December 2015 total number of 64 laparoscopic hysterectomy were performed in our clinic. TLH and vaginal vault closure was performed as described by Ghezzi for all patients...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28508254/comparison-of-pain-within-24%C3%A2-h-after-uterine-artery-embolization-with-tris-acryl-gelatin-microspheres-versus-gelatin-sponge-particles-for-leiomyoma
#3
Tetsuya Katsumori, Hisatomi Arima, Shunsuke Asai, Natsuko Hayashi, Hiroshi Miura
PURPOSE: To compare acute pain after uterine artery embolization (UAE) with tris-acryl gelatin microspheres (TAGM) versus gelatin sponge particles (GS) for leiomyoma. MATERIALS AND METHODS: This was a single-institution, retrospective study. Between July 2008 and November 2016, 101 consecutive patients with symptomatic uterine leiomyoma underwent UAE with the same protocol for post-procedural pain. GS was employed with near-stasis endpoint for the first 49 patients, whereas TAGM was used with limited endpoint for the next 52 patients...
May 15, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28498251/undiagnosed-uterine-sarcomas-identified-during-surgery-for-presumed-leiomyoma-at-a-national-tertiary-hospital-in-thailand-a-10-year-review
#4
Irene Ruengkhachorn, Nisarat Phithakwatchara, Katika Nawapun, Suchanan Hanamornroongruang
OBJECTIVES: The aim of this study was to evaluate the rate, clinical characteristics, and survival outcomes of an undiagnosed uterine malignancy in patients who underwent surgical treatment for presumed leiomyomas. METHODS: Medical records of patients who underwent surgical treatment for presumed leiomyomas, from January 2004 to September 2013, were retrospectively reviewed, and the data were followed until September 2016. Demographic data, tumor characteristics, oncologic treatment, and response rate were analyzed by descriptive statistics...
June 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28490045/uterine-inflammatory-myofibroblastic-tumors-frequently-harbor-alk-fusions-with-igfbp5-and-thbs1
#5
Josh D Haimes, Colin J R Stewart, Brian A Kudlow, Brady P Culver, Bo Meng, Eleanor Koay, Ann Whitehouse, Nichola Cope, Jen-Chieh Lee, Tony Ng, W Glenn McCluggage, Cheng-Han Lee
Inflammatory myofibroblastic tumor (IMT) can occur in a number of anatomic sites, including the uterus. Like its soft tissue counterpart, uterine IMT frequently expresses ALK and harbors ALK genetic rearrangements. The aim of this study is to fully characterize the genetic fusions that occur in uterine IMT. We studied 11 uterine IMTs with typical histology and 8 uterine myxoid smooth muscle tumors (5 leiomyomas, 1 smooth muscle tumor of uncertain malignant potential, and 2 leiomyosarcomas) in which the differential of IMT was considered, using a RNA-sequencing-based fusion assay to detect genetic fusions involving ALK, ROS1, RET, NTRK1/3, and other genes...
June 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28487769/ferric-carboxymaltose-as-treatment-in-women-with-iron-deficiency-anemia
#6
Melvin H Seid, Angelia D Butcher, Ashwin Chatwani
Objective. To evaluate safety and efficacy of intravenous ferric carboxymaltose (FCM) versus standard medical care (SMC) for iron-deficiency anemia (IDA) in postpartum women and women with heavy menstrual bleeding. Study Design. This open-label, multicenter study randomized women with IDA (hemoglobin ≤ 11.0 g/dL) to single doses of FCM (15 mg/kg [maximum 1000 mg]) or SMC (this treatment was determined by the investigator and there may have been no treatment). Safety data (primary outcome) were collected for 30 days...
2017: Anemia
https://www.readbyqxmd.com/read/28487175/epinephrine-induced-takotsubo-cardiomyopathy-during-laparoscopic-myomectomy-case-report-and-review-of-the-literature
#7
Joseph Nassif, Hasan Nahouli, Ali Khali, Elie Mikhael, Walid Gharzeddine, Ghina Ghaziri
Laparoscopic myomectomy, a minimally invasive procedure performed for the management of uterine leiomyomas involves a challenging aspect: excessive local bleeding. Hemorrhage control during laparoscopic myomectomy could be reached through the use of a wide range of vasoconstrictors including epinephrine. Epinephrine is frequently used for the control of local bleeding during surgery; however, it has been associated with several complications. In this case report, we present a rare and unique case of stress-induced cardiomyopathy, also known as Takotsubo cardiomyopathy (TC), caused by intra-myomal injection of epinephrine during laparoscopic myomectomy...
May 6, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28486371/trends-in-mode-of-hysterectomy-after-the-u-s-food-and-drug-administration-power-morcellation-advisory
#8
Helga Ottarsdottir, Sarah L Cohen, Mary Cox, Allison Vitonis, Jon I Einarsson
OBJECTIVE: To evaluate the trends in mode of surgery for benign hysterectomy after the 2014 U.S. Food and Drug Administration (FDA) morcellation guidelines. METHODS: This is a retrospective review of all patients who underwent a hysterectomy for benign indications, specifically for leiomyomas, at Brigham and Women's Hospital from 2013 to 2015. The rates of abdominal, vaginal, laparoscopic, and robotic-assisted laparoscopic hysterectomy as well as the perioperative outcomes were compared over the study period...
May 5, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28483737/primary-hydatid-cyst-mimicking-uterine-leiomyoma
#9
Nermin Koç
Here, we present a rare case of a hydatid cyst in a 25-year-old woman, mimicking a uterine leiomyoma. The patient was admitted with lower abdominal pain and tenesmus, and ultrasonographic examination revealed a 10×10 cm uniloculated mass with regular borders in the myometrium. The patient was operated with an initial diagnosis of a uterine leiomyoma with cystic degeneration, which was found to be hydatid cyst during frozen section and confirmed with the identification of protoscoleces during microscopy. This rare case report indicates the necessity of considering hydatid disease in the differential diagnosis of pelvic cysts, especially in endemic regions...
March 2017: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/28483502/oxidative-stress-a-key-regulator-of-leiomyoma-cell-survival
#10
Nicole M Fletcher, Mohammed S Abusamaan, Ira Memaj, Mohammed G Saed, Ayman Al-Hendy, Michael P Diamond, Ghassan M Saed
OBJECTIVE: To determine the effects of attenuating oxidative stress with the use of dichloroacetate (DCA) on the expression of key redox enzymes myeloperoxidase (MPO) and inducible nitric oxide synthase (iNOS) as well as on apoptosis. DESIGN: Prospective experimental study. SETTING: University medical center. PATIENT(S): Cells established from myometrium and uterine fibroid from the same patients. INTERVENTION(S): Cells were exposed to normal (20% O2) or hypoxic (2% O2) conditions for 24 hours with or without DCA (20 μg/mL), a metabolic modulator that shifts anaerobic to aerobic metabolism...
May 5, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28481790/a-novel-diagnostic-strategy-using-16%C3%AE-18f-fluoro-17-%C3%AE-estradiol-18f-fes-pet-mri-to-achieve-complete-resection-of-intravenous-leiomyomatosis-in-reproductive-age-women
#11
Yoko Chino, Hideaki Tsuyoshi, Tetsuya Tsujikawa, Hidehiko Okazawa, Yoshio Yoshida
Intravenous leiomyomatosis is a life-threatening leiomyoma that grows into the extrauterine venous system. A high recurrence rate has been reported in reproductive-age women who undergo only tumor excision to preserve fertility. Precise diagnosis of tumor extension is essential to achieve complete resection. A 24-year-old woman presented with hypermenorrhea. Contrast-enhanced MRI showed an intramural myoma with worm-like extension into the right parametrium. F-FES PET/MRI accurately depicted the extension with strong FES activity into the right uterine vein, whereas F-FDG PET/MRI excluded the possibility of malignancy...
May 6, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28479027/leiomyoma-infarction-after-uterine-artery-embolization-influence-of-embolic-agent-and-leiomyoma-size-and-location-on%C3%A2-outcome
#12
Eduardo A Lacayo, Danielle L Richman, Michael R Acord, Darcy J Wolfman, Theresa M Caridi, Sameer Y Desale, James B Spies
PURPOSE: To study the factors that might impact infarction of individual uterine leiomyomas and total tumor burden after uterine artery embolization (UAE). MATERIALS AND METHODS: This retrospective study included 91 patients (mean age, 44 y [range, 34-54 y]) who underwent UAE with tris-acryl gelatin microspheres (TAGMs) or nonspherical polyvinyl alcohol (PVA) particles. Twenty-one patients were treated with PVA (23%) and 70 were treated with TAGMs (77%). A total of 356 uterine leiomyomas were assessed, with a median uterine volume of 533 cm(3) (range, 321-848 cm(3))...
May 4, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28471132/a-rare-case-of-leiomyosarcoma-originating-from-the-left-round-ligament-of-the-uterus
#13
Metin Kaba, Aytekin Tokmak, Hakan Timur, Bülent Özdal, Levent Şirvan, Tayfun Güngör
Uterine leiomyosarcomas (LMS) are rare malignancies with a poor prognosis. The incidence is reported to be 3-7/100.000 per year. Preoperative and intraoperative differentiation between LMS and large leiomyoma is always challenging. Therefore, LMS are often diagnosed during postoperative histologic evaluation of hysterectomy or myomectomy specimens. LMS of the round ligament of the uterus which can represent as an inguinal or pelvic mass is extremely rare. To our knowledge, there is only one case report of LMS arising from the round ligament available in the literature...
July 2016: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28471130/non-puerperal-uterine-inversion-due-to-submucous-myoma-in-a-woman-a-case-report
#14
Ayse Kirbas, Korkut Daglar, Ozgur Kara, Ayhan Sucak, Turhan Caglar
Uterine leiomyomas are the most common benign tumor of the female reproductive tract. Their incidence during pregnancy is approximately 2 percent and they are associated with some complications such as preterm labor, placental abruption, fetal malpresentation, obstructed labor, cesarean delivery, and postpartum hemorrhage. They may develop anywhere within the muscular wall of the uterus, including submucosal, intramural, or subserosal areas. Some of the submucous myomas may be pedunculated and eventually may protrude through the cervical canal to the vagina...
July 2016: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28459512/lichong-decoction-reduces-matrix-metalloproteinases-2-expression-but-increases-tissue-inhibitors-of-matrix-metalloproteinases-2-expression-in-a-rat-model-of-uterine-leiomyoma
#15
Yasong Wang, Donghua Li, Xin Xu, Ruiya Qian, Yalan Zhang, Yuhua Huang, Jianguo Geng, Xiaoli Zou, Hongjuan Han, Wufang Zhang
OBJECTIVE: To study the effect of Lichong decoction (LD) on expression of matrix metalloproteinase- 2 (MMP-2) and metalloproteinase-2 (TIMP-2) in a rat model of uterine leiomyoma (UL). METHODS: UL was induced in rats using exogenous estrogen and progesterone. LD was administered (p.o.) for 4 weeks, and mifepristone (RU-486) used as a control. To observe the effect of LD on the uterine coefficient and uterine transverse diameter, a radioimmunoassay method was used to detect serum levels of sex hormones...
August 2016: Journal of Traditional Chinese Medicine, Chung i Tsa Chih Ying Wen Pan
https://www.readbyqxmd.com/read/28453593/-benign-intraperitoneal-metastatic-leiomyomatosis-a-case-report
#16
Paz García, Juan Ignacio Errázuriz, Carlos Fernández, Eugenio Arteaga
Benign intraperitoneal metastatic leiomyomatosis is a rare benign disease that is observed when a leiomyoma is present in the peritoneal surface. Women who have undergone hysterectomy for leiomyomas are most commonly affected. Patients are usually asymptomatic at presentation, being frequently an incidental finding in imaging studies. Ultrasound and CT play an important role in the diagnosis. The lesions are histologically identical to their uterine counterparts. There are different theories about the pathogenesis of the disease, including peritoneal seeding after laparoscopic hysterectomy...
February 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28446940/a-case-of-disseminated-peritoneal-leiomyomatosis-after-two-laparoscopic-procedures-due-to-uterine-fibroids
#17
Michał Ciebiera, Aneta Słabuszewska-Jóźwiak, Kornelia Zaręba, Grzegorz Jakiel
Disseminated peritoneal leiomyomatosis (DPL) is a rare disorder characterized by the presence of multifocal nodules and tumors composed of proliferating smooth muscle tissue, spread throughout the peritoneum. Estrogens and progesterone are considered to be the main factors initiating the formation of disseminated leiomyomatosis. Disseminated peritoneal leiomyomatosis is often asymptomatic, and acyclic vaginal bleeding or pain in the lower abdomen is associated with leiomyomatous rebuilt uterus corpus. Disseminated peritoneal leiomyomatosis can have other ambiguous presentation...
2017: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/28445268/the-use-of-mifepristone-in-abortion-associated-with-an-increased-risk-of-uterine-leiomyomas
#18
Qi Shen, Li Shu, Hui Luo, Xiaoli Hu, Xueqiong Zhu
To investigate the association between widespread use of mifepristone in abortions and risk of uterine leiomyomas.We conducted a case-control study of 305 patients with uterine leiomyomas between January 2011 and July 2012; 311 women with ordinary vaginitis were selected as controls during the same period. Data were collected by questionnaires (including past history, life history, menstruation history, reproductive history, abortion history, the use of mifepristone, and uterine leiomyomas risk factors) and calculated by univariate and multivariate conditional logistic regression analyses; odds ratios and its 95% confidence interval were calculated to estimate the risk for uterine leiomyomas...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28438190/very-small-embryonic-like-stem-cells-vsels-in-adult-mouse-uterine-perimetrium-and-myometrium
#19
Deepa Bhartiya, Kreema James
We have earlier reported the presence of very small embryonic-like stem cells (VSELs) in adult mouse uterus along with slightly bigger progenitors termed endometrial stem cells (EnSCs) and their regulation by ovarian hormones thus demonstrating a crucial role played by them during proliferation, differentiation and remodeling of the endometrium. Present study is a brief communication wherein we have examined the effect of higher dose of estrogen (E, 2 μg/day), progesterone (P, 1 mg/day) and follicle stimulating hormone (FSH, 5 IU/day for 5 days) specifically on the myometrium and perimetrium surrounding the endometrium in bilaterally ovariectomized mice...
April 24, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28432313/multiple-clinical-characteristics-separate-med12-mutation-positive-and-negative-uterine-leiomyomas
#20
Hanna-Riikka Heinonen, Annukka Pasanen, Oskari Heikinheimo, Tomas Tanskanen, Kimmo Palin, Jaana Tolvanen, Pia Vahteristo, Jari Sjöberg, Esa Pitkänen, Ralf Bützow, Netta Mäkinen, Lauri A Aaltonen
Up to 86% of uterine leiomyomas harbour somatic mutations in mediator complex subunit 12 (MED12). These mutations have been associated with conventional histology, smaller tumour size, and larger number of tumours within the uterus. Prior studies, with limited sample sizes, have failed to detect associations between other clinical features and MED12 mutations. Here, we prospectively collected 763 uterine leiomyomas and the corresponding normal myometrial tissue from 244 hysterectomy patients, recorded tumour characteristics, collected clinical data from medical records, and screened the tissue samples for MED12 mutations to assess potential associations between clinical variables and mutation status...
April 21, 2017: Scientific Reports
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