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Uterine Leiomyomas

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https://www.readbyqxmd.com/read/28737576/hereditary-leiomyomatosis-and-renal-cell-carcinoma-syndrome-combined-with-adrenocortical-carcinoma-on-18f-fdg-pet-ct
#1
Xiuyu Guo, Haojun Chen, Hao Fu, Hua Wu
Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome is a recognized distinct phenotypic variant of multiple cutaneous and uterine leiomyomatosis. The present case reports an extremely rare case of HLRCC syndrome combined with adrenocortical carcinoma. The case suggests that HLRCC should be considered in any young patient with bulky uterine leiomyomas and renal cell cancer, and F-FDG PET/CT can help detect unexpected additional primary malignancy in a patient with known cancer.
July 22, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28734973/minimally-invasive-approaches-to-myoma-management
#2
REVIEW
Julian A Gingold, Ndeye-Aicha Gueye, Tommaso Falcone
Patients affected by the presence of leiomyomas may incur a substantial physical, emotional, social and financial toll as well as losses in their quality of life. Although many myomas are not amenable to medical therapy or hysteroscopic resection, many others are amenable to minimally invasive surgical approaches. In patients who prefer to retain their fertility, laparoscopic myomectomy should be considered the intervention of choice. In this review we expand on the surgical techniques of both conventional laparoscopic and robotic-assisted myomectomies...
July 19, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28730656/spontaneous-pregnancy-during-ulipristal-acetate-treatment-of-giant-uterine-leiomyoma
#3
Z Hrgovic, D Habek, J Cerkez Habek, I Hrgovic, S Jerkovic Gulin, D Gulin
WHAT IS KNOWN AND OBJECTIVE: Ulipristal acetate, a progesterone receptor modulator, pharmacologically inhibits endometrial proliferation and thereby prevents pregnancy. It is primarily used as emergency contraception, but also for the treatment of fibroids in women of reproductive age. There have been no published cases of pregnancy, while on therapy with ulipristal acetate. CASE DESCRIPTION: In this article, we present a case report of spontaneous pregnancy during ulipristal acetate therapy...
July 21, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28724848/laparoscopic-excision-of-a-uterine-adenomatoid-tumor-and-a-coexisting-ovarian-teratoma-a-case-report-and-literature-review
#4
Tomohiko Matsuhashi, Ryoko Matsui, Chikako Hasegawa, Tsutomu Hatori, Seiryu Kamoi, Toshiyuki Takeshita
Adenomatoid tumors (ATs) are rare, benign neoplasms occurring mainly in reproductive organs such as the uterus, ovaries, fallopian tubes, and testes. Uterine adenomatoid tumors (UATs) are generally incidentally diagnosed during histopathological examination of excisional biopsies performed for other indications, most commonly uterine leiomyomas. We herein present a 38-year-old woman who underwent laparoscopic excision of a uterine leiomyoma and a right ovarian teratoma. Microscopic examination of the excisional biopsy revealed that the enucleated uterine tumor was composed of proliferating glandular tissue covered with single-layered cells that were surrounded by proliferating smooth muscle cells, corresponding exactly to the features of UATs...
2017: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/28717557/uterine-lipoleiomyoma-a-report-of-two-cases
#5
Haji Mohammed Nazir, Sankesh Mehta, C R Seena, N Kulasekaran
We report two cases of uterine lipoleiomyoma in postmenopausal women of ages 52 and 55 years, who presented with complaints of leukorrhea and lower abdominal pain, respectively. Lipoleiomyoma is a rare benign variant of leiomyoma, having an incidence of 0.03%-0.2%. These are benign pelvic tumors which are usually asymptomatic and commonly occur in obese postmenopausal women. However, they can occasionally present with typical leiomyoma symptoms. Imaging plays a crucial role in the diagnosis of benign pelvic tumors...
2017: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/28708319/experimental-study-on-ablation-of-leiomyoma-by-combination-high-intensity-focused-ultrasound-and-iodized-oil-in-vitro
#6
Zhi-Gang Liang, Yi Gao, Xiao-Yan Ren, Cui Sun, Heng-Fang Gu, Meng Mou, Yan-Bing Xiao
AIM: The aim of the current study was to investigate whether iodized oil (IO) enhances high-intensity focused ultrasound (HIFU) ablation of uterine leiomyoma and to determine the features of hyperechoic changes in the target region. METHODS: Forty samples of uterine leiomyoma were randomly divided into an experimental group and a control group. In the experimental group, the leiomyoma was ablated by HIFU 30 min after 1 mL of iodized oil had been injected into the center of the myoma...
July 14, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28702500/surgical-management-of-a-large-neurilemmoma-like-leiomyoma-of-the-uterine-cervix-mimicking-a-retroperitoneal-tumor
#7
David A Morales F, Oscar Suescún, Laura Martínez, Isabel Dulcey
•A large cervical neurilemmoma-like leiomyoma can simulate a retroperitoneal tumor.•They are extremely rare tumors that require adequate bleeding control.•Comprehensive anatomo-pathological study should be done to rule out malignancy.
August 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28700441/leiomyoma-with-bizarre-nuclei-clinical-and-pathologic-features-of-30-patients
#8
Mehmet Kefeli, Sultan Caliskan, Emel Kurtoglu, Levent Yildiz, Arif Kokcu
Leiomyoma with bizarre nuclei (LBN) have significant cytologic atypia, but high mitotic rate and tumor cell necrosis are absent. Although it is a benign leiomyoma variant, recurrent cases have been described. In this study, we investigated the clinical and pathologic features of LBN and compared them with related studies. A total of 30 patients diagnosed with LBN in our department were included in this study. In all cases, clinical data (age, complaint, surgery type), macroscopic features (size, location, number of leiomyomas, necrosis, and hemorrhage), microscopic features (bizarre cell distribution, bizarre cell density, cellularity, mitotic rate, tumor margin, necrosis, nuclear pseudoinclusions, karyorrhectic nuclei, prominent eosinophilic nucleoli with perinucleolar clearing, cytoplasmic eosinophilic inclusions, staghorn vessels, and alveolar-type edema), and follow-up data (recurrence and survival period) were evaluated...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28700435/ifitm1-outperforms-cd10-in-differentiating-low-grade-endometrial-stromal-sarcomas-from-smooth-muscle-neoplasms-of-the-uterus
#9
Aurelia Busca, Previn Gulavita, Carlos Parra-Herran, Shahidul Islam
Distinguishing between uterine neoplasms of smooth muscle and endometrial stromal origin is a frequent diagnostic challenge. We investigated the staining pattern of interferon-induced transmembrane protein-1 (IFITM1), a novel endometrial stromal marker, in endometrial and smooth muscle uterine neoplasms and compared it with CD10 in its ability to differentiate between these two groups. Immunohistochemistry for IFITM1 and CD10 was performed in 20 cases of smooth muscle neoplasms (10 cases leiomyoma, 10 cases leiomyosarcoma), 14 cases of endometrial stromal sarcoma (ESS) (12 cases of low grade and 2 cases of high grade) and 12 cases of carcinosarcoma...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28700432/novel-fumarate-hydratase-mutation-in-siblings-with-early-onset-uterine-leiomyomas-and-hereditary-leiomyomatosis-and-renal-cell-cancer-syndrome
#10
Vinay Gunnala, Nigel Pereira, Mohamad Irani, Debra Lilienthal, Edyta C Pirog, Robert Soslow, Thomas A Caputo, Rony Elias, Isaac Kligman, Zev Rosenwaks
Hereditary leiomyomatosis renal cell cancer syndrome is an autosomal dominant disorder characterized by uterine and cutaneous leiomyomas and increased predisposition to renal cell carcinoma, papillary type II. The syndrome is caused by heterozygous mutations to the fumarate hydratase (FH) gene located on chromosome 1. Affected females generally present with early onset, atypical uterine leiomyomas and cutaneous findings, however, delays in diagnosis are very common in patients with isolated uterine findings...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28700429/mucosal-proliferations-in-completely-examined-fallopian-tubes-accompanying-ovarian-low-grade-serous-tumors-neoplastic-precursor-lesions-or-normal-variants-of-benign-mucosa
#11
Rebecca J Wolsky, Matt A Price, Charles J Zaloudek, Joseph T Rabban
Malignant transformation of the fallopian tube mucosa, followed by exfoliation of malignant cells onto ovarian and/or peritoneal surfaces, has been implicated as the origin of most pelvic high-grade serous carcinoma. Whether a parallel pathway exists for pelvic low-grade serous tumors [ovarian serous borderline tumor (SBT) and low-grade serous carcinoma (LGSC)] remains to be fully elucidated. The literature is challenging to interpret due to variation in the diagnostic criteria and terminology for cytologically low-grade proliferations of the fallopian tube mucosa, as well as variation in fallopian tube specimen sampling...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28698006/identification-of-tradd-as-a-potential-biomarker-in-human-uterine-leiomyoma-through-itraq-based-proteomic-profiling
#12
Yong Liu, Dan Lu, Jie Sheng, Lijing Luo, Weiyuan Zhang
Recurrent and refractory leiomyoma of uterus is one of the most common diseases in women of reproductive age. Despite its benign nature, uterine leiomyoma has presented an extremely deleterious impact on public health. The etiology of uterine leiomyoma remains unclear and clinical management remains suboptimal, leaving radical hysterectomy the only effective approach. Delineating the molecular mechanism underlying the leiomyoma initiation and progression remains an unmet clinical need. To screen proteins that were differentially expressed in uterine leiomyoma versus normal myometrium, we examined proteomic profile by isobaric tag for relative and absolute quantitation (iTRAQ) labeling coupled with liquid chromatography - tandem mass spectrometry (LC-MS/MS)...
July 8, 2017: Molecular and Cellular Probes
https://www.readbyqxmd.com/read/28697115/selective-progesterone-receptor-modulators-for-the-treatment-of-uterine-leiomyomas
#13
Myriam Safrai, Henry H Chill, Adi Reuveni Salzman, Asher Shushan
Uterine leiomyomas have drawn much attention since being described more than 200 years ago. These common benign uterine tumors often present with prolonged menstrual bleeding, pelvic pressure, and reproductive disorders and pose a true financial burden on health care systems all over the world. Over the past few decades, surgical treatment of uterine leiomyomas has received most of the focus compared with other treatment options. Choosing the appropriate surgical technique depends on many factors such as uterine leiomyoma location, patient's age, interest in future fertility, concomitant comorbidities, and the patient's preference...
July 7, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28693134/prevalence-and-clinical-significance-of-mediator-complex-subunit-12-mutations-in-362-han-chinese-samples-with-uterine-leiomyoma
#14
Juan Wu, Yang Zou, Yong Luo, Jiu-Bai Guo, Fa-Ying Liu, Jiang-Yan Zhou, Zi-Yu Zhang, Lei Wan, Ou-Ping Huang
Uterine leiomyomas (ULs) are the most common gynecological benign tumors originating from the myometrium. Prevalent mutations in the mediator complex subunit 12 (MED12) gene have been identified in ULs, and functional evidence has revealed that these mutations may promote the development of ULs. However, whether MED12 mutations are associated with certain clinical characteristics in ULs remains largely unknown. In the present study, the potential mutations of MED12 and its paralogous gene, mediator complex subunit 12-like (MED12L), were screened in 362 UL tumors from Han Chinese patients...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28689655/robotic-resection-of-a-symptomatic-parasitic-leiomyoma-from%C3%A2-the%C3%A2-obturator-fossa
#15
Gulden Menderes, Belinda Nhundu, Karen Levy, Dan-Arin Silasi
STUDY OBJECTIVE: To demonstrate a technique for robotically resecting a parasitic leiomyoma from the obturator fossa. DESIGN: Case report and a step-by-step video demonstration of resection of a symptomatic parasitic leiomyoma (Canadian Task Force classification III). SETTING: Tertiary referral center in New Haven, Connecticut. INTERVENTIONS: This 48-year-old Caucasian female had undergone a previous total abdominal hysterectomy for uterine leiomyomas...
July 7, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28668161/benign-gynecologic-conditions-of-the-uterus
#16
REVIEW
Zahra Kassam, Iva Petkovska, Carolyn L Wang, Angela M Trinh, Aya Kamaya
In this article, the authors review the anatomy, pathophysiology, MR imaging features, and diagnostic criteria for benign uterine conditions, including adenomyosis, uterine leiomyomas, retained products of conception, and uterine arteriovenous malformations. Pearls, pitfalls, and variants are discussed for each entity as well as important imaging features that can affect management decisions.
August 2017: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/28664937/leiomyoma-with-bizarre-nuclei-a-morphological-immunohistochemical-and-molecular-analysis-of-31-cases
#17
Jennifer A Bennett, Britta Weigelt, Sarah Chiang, Pier Selenica, Ying-Bei Chen, Ann Bialik, Rui Bi, Anne M Schultheis, Raymond S Lim, Charlotte K Y Ng, Vicente Morales-Oyarvide, Robert H Young, Victor E Reuter, Robert A Soslow, Esther Oliva
Leiomyomas associated with hereditary leiomyomatosis and renal cell carcinoma syndrome and leiomyomas with bizarre nuclei often show overlapping morphological features, in particular cells with prominent eosinophilic nucleoli, perinucleolar halos, and eosinophilic cytoplasmic inclusions. Although hereditary leiomyomatosis and renal cell carcinoma syndrome is defined by fumarate hydratase (FH) germline mutations, resulting in S-(2-succino)-cysteine (2SC) formation, it is unknown whether leiomyomas with bizarre nuclei show similar alterations...
June 30, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28658788/pure-uterine-lipoma-a-common-tumour-at-an-uncommon-site
#18
Pranav Pramod Patwardhan, Tejaswini Priyadarshan Waghmare, Annapurna Chandrashekhar Taware
Although lipomas are very common tumours, pure uterine lipomas are extremely rare. Their reported incidence is 0.03-0.2%. They commonly present with symptoms similar to that due to leiomyoma except that they occur in post menopausal elderly females. We report a case of 70-year-old elderly female, who presented with third degree uterovaginal descent. A total vaginal hysterectomy was done for her. The hysterectomy specimen showed presence of a well circumscribed uterine fundal lipoma. We report this case because of its rare occurrence in the uterine fundus...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28653894/molecular-and-clinical-attributes-of-uterine-leiomyomas
#19
REVIEW
Dana Dvorská, Dušan Braný, Zuzana Danková, Erika Halašová, Jozef Višňovský
Uterine leiomyomas, also called uterine fibroids or myomas, represent one of the most common benign tumour types in women of a fertile age. Leiomyomas arise due to transformation of the layer of smooth muscle cells of corpus uteri - the myometrium. Despite frequent occurrence of this disease, the molecular mechanisms behind the origin and development of leiomyomas are still relatively unknown. Most predisposed are obese women and women of African origin. In more than half of cases, leiomyomas remain asymptomatic...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28647614/inefficiency-of-ulipristal-acetate-on-uterus-leiomyomas-as-an-additional-sign-to-suspect-leiomyosarcoma
#20
P Kadhel, M Smail, D Borja De Mozota
The unexpected diagnosis of a leiomyosarcoma from a surgical specimen of a presumed leiomyoma is rare, but with deleterious consequences, especially if morcellation techniques are used. There are currently no effective methods for such a preoperative diagnosis. Ulipristal acetate has demonstrated efficacy for the preoperative treatment of leiomyomas, but not for all patients. We report two cases of leiomyosarcomas in patients treated with ulipristal acetate for a presumed leiomyoma. We propose that ineffective ulipristal acetate treatment may indicate a population in which uterine leiomyosarcoma is more prevalent...
June 21, 2017: Journal of gynecology obstetrics and human reproduction
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