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Uterine Leiomyomas

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https://www.readbyqxmd.com/read/29449196/clinical-predictors-of-successful-vaginal-myomectomy-for-prolapsed-pedunculated-uterine-leiomyoma
#1
Serdar Aydın, Hale Göksever Çelik, Mustafa Maraşlı, Rabia Zehra Bakar
OBJECTIVE: Uterine leiomyomas are the most common pelvic tumor in women. The calculated prevalence of prolapsed pedunculated leiomyoma was 2.5% in patients who underwent surgery. Although vaginal removal is safe and effective, hysterectomy demand is questionable. We aimed to analyze the association between patient characteristics, clinical features of prolapsed pedunculated submucosal leiomyoma and the probability of successful vaginal myomectomy. MATERIALS AND METHODS: This study was conducted in 35 women who presented with prolapsed pedunculated uterine leiomyoma...
February 1, 2018: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/29434846/co-existence-of-benign-gynecological-tumors-with-endometriosis-in-a-group-of-1-000-women
#2
Charoula Matalliotaki, Michail Matalliotakis, Panagiotis Ieromonachou, George N Goulielmos, Maria I Zervou, Aggelos Laliotis, Demetrios A Spandidos, Aydin Arici, Ioannis Matalliotakis
The purpose of this study was two-fold, first to investigate the association between endometriosis and the risk of benign gynecologic tumors and, secondly, to evaluate the distribution of endometrioma and ovarian cysts in women with endometriosis. The medical and pathological reports of 1,000 women with endometriosis were retrospectively reviewed. The incidence of ovarian cysts, uterine leiomyomas and adenomyosis, as well as the side of ovarian cysts were further compared. A total of 295 cases of endometriomas, 172 cases of adenomyosis, 173 cases of ovarian cysts and 89 cases of uterine leiomyomas were confirmed histologically in patients with endometriosis...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29423582/a-retrospective-review-of-48-individuals-including-12-families-molecularly-diagnosed-with-hereditary-leiomyomatosis-and-renal-cell-cancer-hlrcc
#3
Priya T Bhola, Cathy Gilpin, Amanda Smith, Gail E Graham
Hereditary leiomyomatosis and renal cell cancer (HLRCC) is caused by autosomal dominant germline mutations in the fumarate hydratase (FH) gene and is characterized by cutaneous leiomyomas, uterine leiomyomas and aggressive renal malignancies. We conducted a retrospective chart review to characterize the patients referred to our Regional Genetics Program for assessment of HLRCC from 2004 to mid-2016. Forty-eight of 69 (69.5%) referred individuals were positive for a pathogenic or likely pathogenic variant in FH; they had an average age of 39...
February 8, 2018: Familial Cancer
https://www.readbyqxmd.com/read/29423163/metastatic-epicardial-leiomyoma-with-uncertain-malignant-potential
#4
Miroslav P Peev, Anne Therese C Lim, Tianle Zou, Laurence H Brinckerhoff
A 49-year-old female with history of uterine leiomyoma and intermittent shortness of breath presented to the emergency department with new onset of tachycardia and chest pain. Subsequent cardiac work up revealed hypoechoic mass compressing the right ventricle. Computer tomography guided biopsy for tissue characterization revealed a benign spindle cell tumor. Surgical resection of a large epicardial tumor was undertaken. The histologic examination of the tumor was consistent with Estrogen and Progesterone positive leiomyoma of uncertain malignant potential...
September 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29422425/utility-of-clinical-parameters-and-multiparametric-mri-as-predictive-factors-for-differentiating-uterine-sarcoma-from-atypical-leiomyoma
#5
Qiu Bi, Zhibo Xiao, Fajin Lv, Yao Liu, Chunxia Zou, Yiqing Shen
OBJECTIVES: The objective of this study was to find clinical parameters and qualitative and quantitative magnetic resonance imaging (MRI) features for differentiating uterine sarcoma from atypical leiomyoma (ALM) preoperatively and to calculate predictive values for uterine sarcoma. MATERIALS AND METHODS: Data from 60 patients with uterine sarcoma and 88 patients with ALM confirmed by surgery and pathology were collected. Clinical parameters, qualitative MRI features, diffusion-weighted imaging with apparent diffusion coefficient values, and quantitative parameters of dynamic contrast-enhanced MRI of these two tumor types were compared...
February 5, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29420395/ulipristal-acetate-for-treatment-of-symptomatic-uterine-leiomyomas-a-randomized-controlled-trial
#6
James A Simon, William Catherino, James H Segars, Rick E Blakesley, Anna Chan, Vilma Sniukiene, Ayman Al-Hendy
OBJECTIVE: To assess efficacy and tolerability of ulipristal acetate, a selective progesterone receptor modulator, for treatment of symptomatic uterine leiomyomas. METHODS: This phase 3, double-blind, placebo-controlled study enrolled premenopausal women (aged 18-50 years) with abnormal uterine bleeding, one or more discrete leiomyomas, and uterine size 20 weeks of gestation or less. Patients were randomized 1:1:1 to 5 mg ulipristal, 10 mg ulipristal, or placebo once daily for 12 weeks followed by 12-week drug-free follow-up...
February 5, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29416287/hereditary-leiomyomatosis-and-renal-cell-carcinoma-case-report-and-review-of-the-literature
#7
Ferreira Natália, Oliveira Tiago, Oliveira Pedro, Gaspar Sandro
Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a rare genetic disorder in which the affected individuals tend to develop cutaneous leiomyomas, uterine leiomyomas, and renal cell cancer (RCC). Within the spectrum of this syndromic disease, RCC is the most severe manifestation, occurring at a younger age compared to the sporadic form. Pathological suspicion or diagnosis of HLRCC is critical for appropriate clinical management and genetic counseling of the affected family members. In this study, we report the case of a 27-year-old misdiagnosed carrier of HLRCC phenotype, who presented with a large solitary Type II papillary RCC...
January 2018: Urology Annals
https://www.readbyqxmd.com/read/29410151/placenta-increta-after-high-intensity-focused-ultrasound-for-the-treatment-of-a-uterine-leiomyoma
#8
Chin-Ru Ker, Cheng-Yu Long, Ching-Ju Shen
No abstract text is available yet for this article.
January 31, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29406333/a-case-report-of-an-adenomatoid-tumor-of-the-uterus-mimicking-an-endometrioid-adenocarcinoma-on-endometrial-curetting-a-diagnostic-pitfall
#9
Paulette Mhawech-Fauceglia, Damanzoopinder Samroa
Adenomatoid tumors (AT) arising in the female genital tract are usually incidental findings occurring most often in the fallopian tube and uterine serosa and rarely in the myometrium. In the myometrium, they appear grossly as deep seated, small, firm, ill circumscribed nodules mimicking leiomyoma. Histologically they show a glandular and invasive pattern making well-differentiated/low-grade endometrioid adenocarcinoma a major differential diagnosis. However, this differential is rarely encountered in practice because myometrial AT is usually seen on the hysterectomy specimen, because of their anatomic position in the deep myometrium, and only rarely in endometrial curettings...
February 5, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29400019/what-mri-features-suspect-malignant-pure-mesenchymal-uterine-tumors-rather-than-uterine-leiomyoma-with-cystic-degeneration
#10
Tae Hyung Kim, Jae Weon Kim, Sang Youn Kim, Seung Hyup Kim, Jeong Yeon Cho
OBJECTIVE: To retrospectively assess conventional magnetic resonance imaging (MRI) features that differentiate malignant pure mesenchymal uterine tumors (MPMUT); endometrial stromal sarcoma (ESS) and leiomyosarcoma (LMS) from uterine leiomyoma with cystic degeneration (ULCD). METHODS: We retrospectively reviewed magnetic resonance (MR) images of 30 patients with ULCD, 18 with ESS, and 15 with LMS, to assess tumor location, margin, T2 signal intensity (SI), speckled appearance, and peripheral band using univariate and multivariate analyses...
January 4, 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29393434/novel-trerf1-mutations-in-chinese-patients-with-ovarian-endometriosis
#11
Bianna Cao, Yuanfeng Zeng, Fei Wu, Jun Liu, Zeliang Shuang, Xiaoyun Xu, Jiubai Guo
Endometriosis is an estrogen-dependent precancerous lesion exhibiting frequently perturbed level of steroid hormones and transcriptional‑regulating factor 1 (TRERF1) has a crucial role in the production of steroid hormones including estrogen. Endometriosis has previously been revealed to be a precancerous lesion that harbors somatic mutations in cancer‑associated genes. Therefore, the authors of the present study hypothesize that TRERF1 aberrations may be involved in the development of endometriosis. In the present study, endometriotic lesions and paired blood samples from 92 individuals with ovarian endometriosis were analyzed for the potential presence of TRERF1 mutations by sequencing the entire coding region and the corresponding intron‑exon boundaries of the TRERF1 gene...
January 26, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29391329/association-between-fok1-polymorphism-of-vitamin-d-receptor-gene-with-uterine-leiomyoma-in-turkish-populations
#12
Seda Güleç Yılmaz, Tuğçe Gül, Rukset Attar, Gazi Yıldırım, Turgay İşbir
OBJECTIVE: The aim of this research was to determine the association between the fok1 polymorphism and uterine leiomyomas. MATERIAL AND METHODS: For genotyping the fok1 polymorphism of vitamin D receptor, real-time polymerase chain reaction was performed on blood samples of uterine leiomyoma (n=27) and control (n=33) groups. For statistical analyses, SPSS v.23 software (SPSS Inc., Chicago, IL, USA) was used. RESULTS: A statistically significant difference was observed for the frequency of the CC genotype between the uterine leiomyoma and control groups and, the frequencies of the T allele in uterine leiomyoma groups were significantly higher than the control group...
February 2, 2018: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/29390568/uterine-fibroids-with-positive-18f-fdg-pet-ct-image-and-significantly-increased-ca19-9-a-case-report
#13
Yan Ma, Xiaonan Shao
RATIONALE: Uterine fibroids are the most common pelvic solid tumors and common to 25% of women. F-fluorodexyglucose (F-FDG) is an energy metabolism tracer. Although FDG is generally concentrated in malignant lesions with high glucose metabolism, it can also accumulate in normal tissues, benign lesions, and inflammatory sites. The exact mechanism of FDG uptake by uterine fibroids is not clear. Here, we report a case of uterine fibroids with positive F-FDG positron emission tomography/computed tomography (PET/CT) imaging and significantly increased CA19-9...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29386003/whole-exome-sequencing-of-benign-pulmonary-metastasizing-leiomyoma-reveals-mutation-in-the-bmp8b-gene
#14
Deniss Sõritsa, Hindrek Teder, Retlav Roosipuu, Hannes Tamm, Triin Laisk-Podar, Pille Soplepmann, Alan Altraja, Andres Salumets, Maire Peters
BACKGROUND: Benign metastasizing leiomyoma (BML) is an orphan neoplasm commonly characterized by pulmonary metastases consisting of smooth muscle cells. Patients with BML have usually a current or previous uterine leiomyoma, which is therefore suggested to be the most probable source of this tumour. The purpose of this case report was to determine the possible genetic grounds for pulmonary BML. CASE PRESENTATION: We present a case report in an asymptomatic 44-year-old female patient, who has developed uterine leiomyoma with subsequent pulmonary BML...
January 31, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29385977/abnormal-uterine-bleeding-managing-endometrial-dysfunction-and-leiomyomas
#15
Annabelle Brennan, Martha Hickey
Abnormal uterine bleeding refers to any change in the regularity, frequency, heaviness or length of menstruation. There are several potential causes for bleeding disturbance, the two most common being primary endometrial dysfunction and fibroids. Management of abnormal uterine bleeding involves both medical and surgical options and will largely depend on a patient's fertility plans. The use of levonorgestrel-releasing intrauterine devices for heavy menstrual bleeding is increasing in Australia, and they are considered first-line medical management for women accepting of hormonal therapies...
February 5, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/29382566/overexpression-of-the-14-3-3%C3%AE-protein-in-uterine-leiomyoma-cells-results-in-growth-retardation-and-increased-apoptosis
#16
Qi Shen, Xiaoli Hu, Lulu Zhou, Shuangwei Zou, Lu-Zhe Sun, Xueqiong Zhu
Protein 14-3-3γ was significantly reduced in human uterine leiomyoma compared to the adjacent normal myometrium tissue. To investigate the possible link between the reduced 14-3-3γ expression and uterine leiomyoma growth, we have overexpressed 14-3-3γ protein in uterine leiomyomal cells and its effects on cell proliferation and apoptosis were analyzed. Over-expression of 14-3-3γ was achieved by transducing into two types of uterine leiomyoma cells (primary culture cells and immortal stem cells) with a 14-3-3γ expressing adenovirus vector...
January 27, 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29381777/the-akt-bcl-2-axis-mediates-survival-of-uterine-leiomyoma-in-a-novel-3d-spheroid-model
#17
Vania Vidimar, Debabrata Chakravarti, Serdar E Bulun, Ping Yin, Romana Nowak, Jian-Jun Wei, J Julie Kim
A deeper understanding of the pathways that drive uterine leiomyoma (ULM) growth and survival requires model systems that more closely mimic the in vivo tumors. This would provide new insights into developing effective therapeutic strategies for these common benign tumors of childbearing-aged women. In this study, we examined the role of BCL-2 in mediating ULM survival in the context of increased AKT and oxidative stress using a novel 3-dimensional (3D), spheroid-based model that more closely resembles the native ULM tumor microenvironment...
January 26, 2018: Endocrinology
https://www.readbyqxmd.com/read/29375226/increased-risk-of-venous-thromboembolism-in-women-with-uterine-leiomyoma-a-nationwide-population-based-case-control-study
#18
Hung-Kai Huang, Chew-Teng Kor, Ching-Pei Chen, Hung-Te Chen, Po-Ta Yang, Chen-Dao Tsai, Ching-Hui Huang
Background: Venous thromboembolism (VTE) is a sex-specific disease that has different presentations between men and women. Women with uterine leiomyoma can present with VTE without exhibiting the traditional risk factors. We investigated the relationship between a history of uterine leiomyoma and the risk of VTE using the National Health Insurance Research Database (NHIRD). Methods: We conducted a retrospective, nationwide, population-based case-control study using the NHIRD...
January 2018: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29373116/uncommon-hereditary-gynaecological-tumour-syndromes-pathological-features-in-tumours-that-may-predict-risk-for-a-germline-mutation
#19
REVIEW
Karuna Garg, Anthony N Karnezis, Joseph T Rabban
The most common hereditary gynaecological tumour syndromes are hereditary breast and ovarian cancer syndrome and Lynch syndrome. However, pathologists also may encounter gynaecological tumours in women with rare hereditary syndromes. Many of these tumours exhibit distinctive gross and microscopic features that are associated with a risk for an inherited gene mutation. The sensitivity and specificity of these tumour pathology features for predicting an inherited mutation vary depending on the syndrome. By recognising these tumour features, pathologists may potentially contribute to the diagnosis of an unsuspected syndrome by recommending referral of the patient for formal risk assessment by genetic counselling...
January 17, 2018: Pathology
https://www.readbyqxmd.com/read/29372159/the-expression-of-m%C3%A3-llerian-inhibiting-substance-anti-m%C3%A3-llerian-hormone-type-ii-receptor-in-myoma-and-adenomyosis
#20
Shin Young Kim, Hye Min Moon, Min Kyoung Lee, Youn Jee Chung, Jae Yen Song, Hyun Hee Cho, Mee Ran Kim, Jang Heub Kim
Objective: We compared the expression levels of Müllerian inhibiting substance (MIS)/anti-Müllerian hormone type II receptor (AMHRII) in uterine myoma and adenomyosis to evaluate the possibility of using MIS/anti-Müllerian hormone (AMH) as a biological regulator or therapeutic agent in patients with uterine leiomyoma and adenomyosis. Methods: We studied normal uterine myometrium, leiomyoma, endometrial tissue, and adenomyosis from 57 patients who underwent hysterectomy for uterine leiomyoma (22 cases) or adenomyosis (28 cases) and myomectomy for uterine myoma (7 cases)...
January 2018: Obstetrics & Gynecology Science
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