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https://www.readbyqxmd.com/read/29454137/mechanisms-and-management-of-refractory-ventricular-arrhythmias-in-the-age-of-autonomic-modulation
#1
Jason S Bradfield, Olujimi A Ajijola, Marmar Vaseghi, Kalyanam Shivkumar
Ventricular arrhythmias are responsible for hundreds of thousands of deaths every year. Catheter ablation of ventricular tachycardia (VT) is an essential component of the management of these life-threatening arrhythmias. However, in many patients, despite medical and interventional therapy, VT recurs. Further, some VT substrates (mid-myocardial, left ventricular summit, intra-septal) are not easily targeted, due to limitations of currently available technology. In certain clinical settings, ventricular fibrillation (VF) episodes that have premature ventricular contraction (PVC) triggers can also be targeted with catheter ablation...
February 14, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29453593/risk-marker-profiles-in-patients-treated-with-percutaneous-septal-ablation-for-symptomatic-hypertrophic-obstructive-cardiomyopathy
#2
Amelie Burghardt, Frank van Buuren, Zisis Dimitriadis, Tim Grübbel, Hubert Seggewiss, Smita Scholtz, Dieter Horstkotte, Lothar Faber
BACKGROUND AND STUDY OBJECTIVE: Different studies have shown a good long-term survival with improvement of symptoms and hemodynamics after percutaneous septal ablation (PTSMA), similar to myectomy considered to be the therapeutic "gold standard" for symptomatic hypertrophic obstructive cardiomyopathy (HOCM). Furthermore, desobliteration of left ventricular (LV) outflow may modify features of the disease considered to be risk-relevant, such as magnitude of LV hypertrophy, outflow gradient, and left atrial (LA) size...
February 16, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29452709/late-restored-cardiac-function-after-successful-resynchronization-by-right-posterior-accessory-pathway-ablation-in-wolff-parkinson-white-syndrome-associated-dilated-cardiomyopathy
#3
Kun-Lang Wu, Shuenn-Nan Chiu, Chun-An Chen, Chun-Wei Lu, Wei-Chieh Tseng, Jou-Kou Wang, Mei-Hwan Wu
No abstract text is available yet for this article.
February 8, 2018: Journal of Electrocardiology
https://www.readbyqxmd.com/read/29452352/conditional-ablation-and-conditional-rescue-models-for-casq2-elucidate-the-role-of-development-and-of-cell-type-specific-expression-of-casq2-in-the-cpvt2-phenotype
#4
Daniel J Flores, ThuyVy Duong, Luke O Brandenberger, Apratim Mitra, Aditya Shirali, John C Johnson, Danielle Springer, Audrey Noguchi, Zu-Xi Yu, Steven N Ebert, Andreas Ludwig, Bjorn C Knollmann, Mark D Levin, Karl Pfeifer
Cardiac calsequestrin (Casq2) associates with the Ryanodine Receptor 2 channel in the junctional sarcoplasmic reticulum to regulate Ca2+ release into the cytoplasm. Patients carrying mutations in CASQ2 display low resting heart rates under basal conditions and stress-induced polymorphic ventricular tachycardia (CPVT). In this study we generate and characterize novel conditional deletion and conditional rescue mouse models to test the influence of developmental programs on the heart rate and CPVT phenotypes...
February 14, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29450766/septal-myectomy-for-hypertrophic-cardiomyopathy-important-surgical-knowledge-and-technical-tips-in-the-era-of-increasing-alcohol-septal-ablation
#5
REVIEW
Yuting P Chiang, Yuichi J Shimada, Jonathan Ginns, Shepard D Weiner, Hiroo Takayama
Hypertrophic cardiomyopathy (HCM) is the most commonly inherited cardiac disease-recent studies suggest a prevalence as high as 1 in 200. For symptomatic patients with obstructive HCM who are refractory to medical therapy, septal reduction is indicated. Septal myectomy (SM) is considered the gold standard septal reduction technique. However, due to a shortage of surgeons who are experienced in this technique, alcohol septal ablation (ASA) has overtaken SM as the most commonly performed procedure for obstructive HCM...
February 15, 2018: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29450695/a-clinical-approach-to-arrhythmias-revisited-in-2018-from-ecg-over-noninvasive-and-invasive-electrophysiology-to-advanced-imaging
#6
REVIEW
L Jordaens
Understanding arrhythmias and their treatment is not always easy. The current straightforward approach with catheter ablation and device therapy is an amazing achievement, but does not make management of underlying or other cardiac disease and pharmacological therapy unnecessary. The goal of this paper is to describe how much of the knowledge of the 1980s and early 1990s can and should still be applied in the modern treatment of patients with arrhythmias. After an introduction, this review will focus on paroxysmal atrial fibrillation and a prototype of 'idiopathic' ventricular arrhythmias, two diseases with a striking similarity, and will discuss the arrhythmogenesis...
February 15, 2018: Netherlands Heart Journal
https://www.readbyqxmd.com/read/29449354/high-resolution-infrared-thermography-of-esophageal-temperature-during-radiofrequency-ablation-of-atrial-fibrillation
#7
Matthew G Daly, Iain Melton, Graham Roper, Gary Lim, Ian G Crozier
BACKGROUND: Catheter ablation for atrial fibrillation has potential to cause esophageal thermal injury. Esophageal temperature monitoring during ablation is commonly used; however, it has not eliminated thermal injuries, possibly because conventional sensors have poor spatial sampling and response characteristics. To enhance understanding of temperature dynamics that may underlie esophageal injury, we tested a high-resolution, intrabody, infrared thermography catheter to continuously image esophageal temperatures during ablation...
February 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29444267/safety-of-laser-interstitial-thermal-therapy-in-patients-with-pacemakers
#8
Sanjeet S Grewal, Krzysztof R Gorny, Christopher P Favazza, Robert E Watson, Timothy J Kaufmann, Jamie J Van Gompel
BACKGROUND AND IMPORTANCE: Laser interstitial thermal therapy (LiTT) has increasingly been used as a treatment option for medically refractory epilepsy, tumors, and radiation necrosis. The use of LiTT requires intraoperative magnetic resonance (MR) thermography. This can become an issue in patients with other implanted therapeutic devices such as pacemakers and vagal nerve stimulators due to concerns regarding increases in the specific absorption rate (SAR). This is a technical case report demonstrating a successfully and safely performed LiTT in a 1...
February 10, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29438530/hypertrophic-obstructive-cardiomyopathy-what-when-why-for-whom
#9
Carlos A Mestres, Thomas Bartel, Antonio Sorgente, Silvana Müller, Christiane Gruner, Joseph Dearani, Eduard Quintana
Hypertrophic cardiomyopathy is the most common genetic cardiovascular disorder and is associated with symptoms of heart failure and increased risk of sudden cardiac death. The most common condition is obstruction of the left ventricular outflow tract. Surgical septal myectomy and alcohol septal ablation are the 2 accepted modes of septal reduction therapy and are indicated when there are advanced symptoms and a peak left ventricular outflow gradient ≥50 mmHg. Advantages of alcohol septal ablation are limited groin approach, reduction of obstruction of the left ventricular outflow tract and functional improvement, but there are higher chances for intracardiac device implantation and residual obstruction...
February 9, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29431260/a-feasibility-study-of-non-invasive-ablation-of-ventricular-tachycardia-using-high-intensity-focused-ultrasound
#10
Fei Lü, Wei Huang, David G Benditt
BACKGROUND: Current transcatheter ablation of ventricular tachycardia (VT) techniques is limited in part by its invasive nature and superficial depth of ablation lesions. OBJECTIVES: This study was aimed at evaluating the feasibility of targeted ablation of cardiac tissues using high-intensity focused ultrasound (HIFU) as a potential means for non-invasive ablation of VT. METHODS: Ablation of ventricular myocardium was performed in anesthetized closed-chest dogs using a HIFU therapeutic system that is currently used clinically for ablation of human solid tumors...
February 12, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29429375/mechanical-fractionation-of-tissues-using-microsecond-long-hifu-pulses-on-a-clinical-mr-hifu-system
#11
Avinash Eranki, Navid Farr, Ari Partanen, Karun V Sharma, Christopher T Rossi, Avi Z Rosenberg, AeRang Kim, Matthew Oetgen, Haydar Celik, David Woods, Pavel S Yarmolenko, Peter C W Kim, Bradford J Wood
PURPOSE: High intensity focused ultrasound (HIFU) can non-invasively treat tumors with minimal or no damage to intervening tissues. While continuous-wave HIFU thermally ablates target tissue, the effect of hundreds of microsecond-long pulsed sonications is examined in this work. The objective of this study was to characterize sonication parameter-dependent thermomechanical bioeffects to provide the foundation for future preclinical studies and facilitate clinical translation. METHODS AND MATERIALS: Acoustic power, number of cycles/pulse, sonication time, and pulse repetition frequency (PRF) were varied on a clinical magnetic resonance imaging (MRI) - guided HIFU (MR-HIFU) system...
February 11, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29429026/modulation-of-renal-sympathetic-innervation-recent-insights-beyond-blood-pressure-control
#12
REVIEW
Dominik Linz, Mathias Hohl, Adrian D Elliott, Dennis H Lau, Felix Mahfoud, Murray D Esler, Prashanthan Sanders, Michael Böhm
Renal afferent and efferent sympathetic nerves are involved in the regulation of blood pressure and have a pathophysiological role in hypertension. Additionally, several conditions that frequently coexist with hypertension, such as heart failure, obstructive sleep apnea, atrial fibrillation, renal dysfunction, and metabolic syndrome, demonstrate enhanced sympathetic activity. Renal denervation (RDN) is an approach to reduce renal and whole body sympathetic activation. Experimental models indicate that RDN has the potential to lower blood pressure and prevent cardio-renal remodeling in chronic diseases associated with enhanced sympathetic activation...
February 10, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/29427821/image-based-criteria-to-identify-the-presence-of-epicardial-arrhythmogenic-substrate-in-patients-with-transmural-myocardial-infarction
#13
David Soto-Iglesias, Juan Acosta, Diego Penela, Juan Fernández-Armenta, Mario Cabrera, Mikel Martínez, Francesca Vassanelli, Alejandro Alcaine, Markus Linhart, Beatriz Jáuregui, Elena Efimova, Rosario J Perea, Susana Prat-González, José T Ortiz-Pérez, Xavier Bosch, Luis Mont, Oscar Camara, Antonio Berruezo
BACKGROUND: Patients with transmural myocardial infarction (MI) who undergo endocardial-only substrate ablation are at an increased risk of ventricular tachycardia (VT) recurrence. Late gadolinium-enhanced cardiac magnetic resonance (LGE-CMR) could be used to assess infarct transmurality (IT). However, the degree of IT associated to epicardial arrhythmogenic substrate (AS) has not been determined. OBJECTIVE: To determine the degree of IT observed in LGE-CMR and multi-detector computed tomography (MDCT) that predicts the presence of epicardial AS...
February 7, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29427756/crispr-cas9-ablation-of-individual-mirnas-from-a-mirna-family-reveals-their-individual-efficacies-for-regulating-cardiac-differentiation
#14
Ziyao Zhang, Rebecca Ursin, Samiksha Mahapatra, G Ian Gallicano
Although it is well understood that genetic mutations, chromosomal abnormalities, and epigenetic miscues can cause congenital birth defects, many defects are still labeled idiopathic, meaning their origin is not yet understood. microRNAs are quickly entering the causal fray of developmental defects. miRNAs use a 7-8 base-pair seed sequence to target a corresponding sequence on one or multiple mRNAs resulting in rapid down-regulation of translation. miRNAs can also control protein 'amounts' in cells. As a result if miRNAs are over or under expressed during development protein homeostasis can be compromised resulting in defects in the development of organ systems...
February 7, 2018: Mechanisms of Development
https://www.readbyqxmd.com/read/29422281/anesthesia-for-cardiac-ablation
#15
REVIEW
Satoru Fujii, Jian Ray Zhou, Achal Dhir
As the complexity and duration of cardiac ablation procedures increase, there is a growing demand for anesthesiologist involvement in the electrophysiology suites for sedation and anesthesia provision, hemodynamic and neuromonitoring, and procedural guidance through transesophageal echocardiography. To deliver high-quality perioperative care, it is important that the anesthesiologist is intimately familiar with the evolving techniques and technologies, the anesthetic options and ventilation strategies, and the anticipated postprocedural complications...
December 23, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29415917/contiguity-between-ablation-lesions-and-strict-catheter-stability-settings-assessed-by-visitagtm-module-improve-clinical-outcomes-of-paroxysmal-atrial-fibrillation-ablation%C3%A3-results-from-the-visitaly-study
#16
Giulio Zucchelli, Giusy Sirico, Luca Rebellato, Massimiliano Marini, Giuseppe Stabile, Maurizio Del Greco, Antonello Castro, Ermenegildo De Ruvo, Ezio Soldati, Gianluca Zingarini, Salvatore Ocello, Elisabetta Daleffe, Massimo Mantica, Claudio Pandozi, Massimiliano Maines, Fabrizio Guarracini, Maria Grazia Bongiorni
BACKGROUND: Our aim was to evaluate the clinical outcome of paroxysmal atrial fibrillation (AF) ablation with contact force technology, using an automated lesion tagging system (VISITAGTM module) with strict criteria of catheter stability.Methods and Results:We enrolled 200 consecutive patients who underwent pulmonary vein isolation (PVI) in 11 centers and were followed up for 12 months. The stability setting was within 3 mm for ≥10 s and for ≥15 s in 47% and 53% of patients, respectively...
February 8, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29410186/optimal-approach-for-repair-of-left-atrial-esophageal-fistula-complicating-radiofrequency-ablation
#17
W Hampton Gray, Fernando Fleischman, Mark J Cunningham, Anthony W Kim, Craig J Baker, Vaughn A Starnes, P Michael McFadden
Left atrial-esophageal fistula (AEF) following endovascular radiofrequency (RF) ablation for cardiac arrhythmias is a life threatening complication. Immediate surgical repair offers the best chance for survival. The optimal surgical technique is unknown. We describe our recommended surgical approach.
February 1, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29409092/-gallop-in-the-routineergometrie-only-chore-or-diagnostic-challenge
#18
Stephan Knöchner, K Kronberg, U Schumann
ANAMNESIS:  A 47-year-old recreational sportsman showed in a routine ergometry polymorphic ventricular extrasystoles with good physical performance. INVESTIGATIONS:  In resting ECG impressed ventricular extrasystoles (VES) predominantly right-hand-block-like with superior axis, a long-term ECG yielded up to 100 VES per hour. Echocardiographically imposing 4 - 5 trabeculae, feathered, reticular structures apically in the left and lower in the right ventricle...
February 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29409086/-update-ventricular-tachycardia
#19
Alexander Fürnkranz, Hisaki Makimoto
Idiopathic ventricular tachycardia: Frequent monomorphic premature ventricular contractions or non-sustained ventricular tachycardia without underlying structural heart disease is not a rare condition and may cause significant symptoms. A subgroup of patients develops IVT-associated cardiomyopathy. Current ESC guidelines recommend primary catheter ablation in symptomatic patients with right ventricular outflow tract IVT. Catheter ablation is also recommended in symptomatic patients with a left ventricular outflow tract (or other rare) origin, if antiarrhythmic drugs are ineffective or not desired...
February 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29405947/class-ic-antiarrhythmic-drugs-for-suspected-premature-ventricular-contraction-induced-cardiomyopathy
#20
Matthew C Hyman, Danielle Mustin, Gregory Supple, Robert D Schaller, Pasquale Santangeli, Jeffrey Arkles, David Lin, Daniele Muser, Sanjay Dixit, Saman Nazarian, Andrew E Epstein, David J Callans, Francis E Marchlinski, David S Frankel
BACKGROUND: Class IC antiarrhythmic drugs (IC-AADs) can effectively suppress premature ventricular contractions (PVCs). However, IC-AADs increase mortality in patients with PVCs and left ventricular dysfunction after myocardial infarction. Whether IC-AADs can be safely used to treat premature ventricular contraction-induced cardiomyopathy (PVC-CM) remains to be established. OBJECTIVE: The purpose of this study was to determine the safety and efficacy of IC-AADs in patients suspected of having PVC-CM...
February 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
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