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https://www.readbyqxmd.com/read/28211197/recurrences-in-the-blanking-period-and-12-month-success-rate-by-continuous-cardiac-monitoring-after-cryoablation-of-paroxysmal-and-non-paroxysmal-atrial-fibrillation
#1
Paolo Pieragnoli, Alessandro Paoletti Perini, Giuseppe Ricciardi, Luca Checchi, Andrea Giomi, Iacopo Muraca, Letizia Mannucci, Luigi Padeletti
INTRODUCTION: Recurrences within the blanking period (early recurrences) are common after atrial fibrillation (AF) ablation by pulmonary vein isolation (PVI), but their clinical significance is still controversial. We aimed at evaluating the significance of within-blanking recurrences at 12-month follow-up after cryoballoon (CB) PVI, and to assess the real procedural success rate by continuous monitoring of cardiac rhythm. METHODS AND RESULTS: Sixty consecutive AF patients (34 paroxysmal, 56...
February 17, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28209764/kcnj11-ablation-is-associated-with-increased-nitro-oxidative-stress-during-ischemia-reperfusion-injury-implications-for-human-ischemic-cardiomyopathy
#2
Bo Zhang, Tatiana Novitskaya, Debra G Wheeler, Zhaobin Xu, Elena Chepurko, Ryan Huttinger, Heng He, Saradhadevi Varadharaj, Jay L Zweier, Yanna Song, Meng Xu, Frank E Harrell, Yan Ru Su, Tarek Absi, Mark J Kohr, Mark T Ziolo, Dan M Roden, Christian M Shaffer, Cristi L Galindo, Quinn S Wells, Richard J Gumina
BACKGROUND: Despite increased secondary cardiovascular events in patients with ischemic cardiomyopathy (ICM), the expression of innate cardiac protective molecules in the hearts of patients with ICM is incompletely characterized. Therefore, we used a nonbiased RNAseq approach to determine whether differences in cardiac protective molecules occur with ICM. METHODS AND RESULTS: RNAseq analysis of human control and ICM left ventricular samples demonstrated a significant decrease in KCNJ11 expression with ICM...
February 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28209216/hypertrophic-cardiomyopathy-with-left%C3%A2-ventricular-apical-aneurysm-implications-for-risk-stratification-and-management
#3
Ethan J Rowin, Barry J Maron, Tammy S Haas, Ross F Garberich, Weijia Wang, Mark S Link, Martin S Maron
BACKGROUND: A previously under-recognized subset of hypertrophic cardiomyopathy (HCM) patients with left ventricular (LV) apical aneurysms is being identified with increasing frequency. However, risks associated with this subgroup are unknown. OBJECTIVES: The authors aimed to clarify clinical course and prognosis of a large cohort of HCM patients with LV apical aneurysms over long-term follow-up. METHODS: The authors retrospectively analyzed 1,940 consecutive HCM patients at 2 centers, 93 of which (4...
February 21, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28205119/use-of-three-dimensional-computed-tomography-overlay-for-real-time-cryoballoon-ablation-in-atrial-fibrillation-reduces-radiation-dose-and-contrast-dye
#4
B Oude Velthuis, M Molenaar, H G Reinhart Dorman, J Y Stevenhagen, M F Scholten, J van der Palen, J M van Opstal
AIMS: Cryoballoon pulmonary vein (PV) isolation in patients with atrial fibrillation has proven to be effective in short-term and long-term follow-up. To visualise the PV anatomy, pre-ablation contrast pulmonary venography is commonly performed. Three-dimensional (3D) computed tomography (CT) overlay is a new technique creating a live 3D image of the left atrium by integrating a previously obtained CT scan during fluoroscopy. To evaluate the benefits of 3D CT overlay during cryoballoon ablation, we studied the use of 3D CT overlay versus contrast pulmonary venography in a randomised fashion in patients with paroxysmal atrial fibrillation undergoing cryoballoon PV isolation...
February 15, 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/28205094/knockdown-of-cardiac-kir3-1-gene-with-sirna-can-improve-bradycardia-in-an-experimental-sinus-bradycardia-rat-model
#5
Yang Li, Xiaodan Fu, Zhi Zhang, Bo Yu
The objective of this study was to explore whether the inhibition of potassium inwardly rectifying channel (Kir3.1) with short interfering RNA (siRNA) can improve bradycardia in an experimental sinus bradycardia rat model. 54 Sprague Dawley (SD) rats were randomly divided into three groups: experimental group, control group, and sham group. Sinus bradycardia model was established in SD rats through chemical ablation of sinoatrial (SA) node with 20% formaldehyde. Variations of Kir3.1 expression at mRNA and protein level were examined with qPCR and Western blotting...
February 15, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28202630/targets-and-end-points-in-cardiac-autonomic-denervation-procedures
#6
Esteban W Rivarola, Denise Hachul, Tan Wu, Cristiano Pisani, Carina Hardy, Fabrizio Raimundi, Sissy Melo, Francisco Darrieux, Mauricio Scanavacca
BACKGROUND: Autonomic denervation is an alternative approach for patients with symptomatic bradycardia. No consensus exists on the critical targets and end points of the procedure. The aim of this study was to identify immediate end points and critical atrial regions responsible for vagal denervation. METHODS AND RESULTS: We enrolled 14 patients (50% men; age: 34.0±13.8 years) with cardioinhibitory syncope, advanced atrioventricular block or sinus arrest, and no structural heart disease...
February 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28196927/healthcare-utilization-and-expenditures-associated-with-appropriate-and-inappropriate-implantable-defibrillator-shocks
#7
Mintu P Turakhia, Steven Zweibel, Andrea L Swain, Sarah A Mollenkopf, Matthew R Reynolds
BACKGROUND: In patients with implantable cardioverter-defibrillators, healthcare utilization (HCU) and expenditures related to shocks have not been quantified. METHODS AND RESULTS: We performed a retrospective cohort study of patients with implantable cardioverter-defibrillators identified from commercial and Medicare supplemental claims databases linked to adjudicated shock events from remote monitoring data. A shock event was defined as ≥1 spontaneous shocks delivered by an implanted device...
February 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28190707/safety-and-efficacy-of-percutaneous-microwave-hepatic-ablation-near-the-heart
#8
George A Carberry, Amanda R Smolock, Mircea Cristescu, Shane A Wells, Timothy J Ziemlewicz, Meghan G Lubner, J Louis Hinshaw, Christopher L Brace, Fred T Lee
PURPOSE: To evaluate safety and efficacy of percutaneous hepatic microwave (MW) ablation performed near the heart. MATERIALS AND METHODS: This study reviewed 118 consecutive peripheral (ablation zone margins within 5 mm of liver capsule) percutaneous MW hepatic ablations performed between June 2010 and August 2015. Ablation zones of 27 tumors (22.8%) extended to ≤ 5 mm from myocardium, and these ablations comprised the study group; the remaining ablations formed the control group...
February 9, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28188930/microrna-135a-regulates-sodium-calcium-exchanger-gene-expression-and-cardiac-electrical-activity
#9
Eric Duong, Jiening Xiao, Xiao Yan Qi, Stanley Nattel
BACKGROUND: Complete atrioventricular block (CAVB) causes arrhythmogenic remodeling and increases the risk of Torsades de Pointes (TdP) arrhythmias. MicroRNAs (miRNAs) are key regulators of gene-expression that contribute to cardiac remodeling. OBJECTIVE: To assess miRNA changes after complete atrioventricular block (CAVB) and identify novel candidates potentially involved in arrhythmogenic cardiac remodeling. METHODS: CAVB was induced in mice via His bundle ablation...
February 7, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28187972/late-results-of-the-cox-maze-iv-procedure-in-patients-undergoing-coronary-artery-bypass-grafting
#10
Matthew R Schill, Farah N Musharbash, Vivek Hansalia, Jason W Greenberg, Spencer J Melby, Hersh S Maniar, Laurie A Sinn, Richard B Schuessler, Marc R Moon, Ralph J Damiano
OBJECTIVE: Most patients with atrial fibrillation (AF) undergoing cardiac surgery do not receive concomitant ablation. This study reviewed outcomes of patients with AF undergoing Cox-maze IV (CMIV) procedure with radiofrequency and cryoablation and coronary artery bypass grafting (CABG) at our institution. METHODS: Between the introduction of radiofrequency ablation in 2002 and 2015, 135 patients underwent left- or biatrial CMIV with CABG. Patients undergoing other cardiac procedures, except mitral valve repair, or who had emergent, reoperative, or off-pump procedures were excluded...
January 16, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28185360/effect-of-environmental-impedance-surrounding-a-radiofrequency-ablation-catheter-electrode-on-lesion-characteristics
#11
Duy T Nguyen, Kianna Nguyen, Lijun Zheng, Joseph Schuller, Matthew Zipse, Wendy S Tzou, William H Sauer
INTRODUCTION: The electrical conductivity of the environment surrounding a catheter electrode may affect radiofrequency (RF) current. A higher impedance environment enveloping a catheter tip can be insulating and thus direct RF preferentially into targeted cardiac tissue. We sought to evaluate whether different environmental impedances will affect RF lesions. METHODS: An ex vivo model using bovine myocardium, load cell, and 4 mm ablation catheter was tested using a circulating bath of normal (0...
February 10, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28183572/cervical-sympathetic-blockade-for-the-management-of-electrical-storm
#12
Rehan Ali, Jeffrey Ciccone, Victor Tseng
A 75-year-old man presented with dizziness and fatigue secondary to ventricular and supraventricular arrhythmias. He underwent an elective ablation but continued to suffer from ventricular tachycardia with cardiovascular instability despite antiarrhythmic therapy with multiple agents. The patient continued to develop episodes of ventricular tachycardia and an episode of ventricular fibrillation. Electrical storm encompasses a situation of cardiac instability which may present as several episodes of ventricular tachycardia or ventricular fibrillation in a short period...
February 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28167318/temperature-monitoring-by-channel-data-delays-feasibility-based-on-estimated-delays-magnitude-for-cardiac-ablation
#13
Margot Pasternak, Eigil Samset, Jan D'hooge, Geir U Haugen
Ultrasound thermometry is based on measuring tissue temperature by its impact on ultrasound wave propagation. This study focuses on the use of transducer array channel data (not beamformed) and examines how a layer of increased velocity (heat induced) affects the travel-times of the ultrasound backscatter signal. Based on geometric considerations, a new equation was derived for the change in time delay as a function of temperature change. The resulting expression provides insight into the key factors that link change in temperature to change in travel time...
January 16, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28167089/alternative-approaches-for-ablation-of-resistant-ventricular-tachycardia
#14
REVIEW
Carola Gianni, Sanghamitra Mohanty, Chintan Trivedi, Luigi Di Biase, Amin Al-Ahmad, Andrea Natale, J David Burkhardt
Ventricular tachycardia (VT) ablation is usually performed with an ablation catheter that delivers unipolar radiofrequency (RF) energy to eliminate the re-entry circuit responsible for VT. However, there are some instances when unipolar RF ablation fails, notably in VTs with a deep intramural origin, or cases in which epicardial access is not attainable due to prior cardiac surgery. To overcome these limitations, several alternative approaches have been used in clinical practice, including alcohol ablation or coil embolization, simultaneous unipolar or bipolar RF ablation, surgical ablation, or noninvasive ablation with stereotactic radiosurgery...
March 2017: Cardiac Electrophysiology Clinics
https://www.readbyqxmd.com/read/28167085/catheter-ablation-for-ventricular-tachycardia-in-patients-with-nonischemic-cardiomyopathy
#15
REVIEW
Nathaniel Thompson, Antonio Frontera, Masateru Takigawa, Ghassen Cheniti, Gregoire Massoullie, Hubert Cochet, Arnaud Denis, Arnaud Chaumeil, Nicolas Derval, Meleze Hocini, Michel Haissaguerre, Pierre Jais, Frederic Sacher
Although catheter ablation has been successful in reducing the recurrence of ventricular tachycardia in patients with ischemic disease, outcomes in patients with nonischemic cardiomyopathy (NICM) have not met with the same results. Success is predicated on a methodical approach to diagnosis of disease type and identification of critical substrate, and the ablation strategies used. Cardiac MRI with delayed enhancement is able to identify areas of substrate involvement, particularly in situations when conventional catheter mapping is not able to do so...
March 2017: Cardiac Electrophysiology Clinics
https://www.readbyqxmd.com/read/28167081/premature-ventricular-complex-ablation-in-structural-heart-disease
#16
REVIEW
Rakesh Latchamsetty, Frank Bogun
Frequent premature ventricular complexes (PVCs) in patients with underlying structural heart disease, particular after myocardial infarction, can predict increased mortality. Use of antiarrhythmic medications to suppress PVCs in this setting can result in a further increase in mortality. High PVC burdens in patients with structural heart disease can cause or worsen cardiomyopathy and successful elimination of PVCs with catheter ablation can improve or, in some cases normalize, cardiac function. PVCs may also trigger more malignant ventricular arrhythmias, particularly in patients with previous myocardial infarction, and when identified can be mapped and ablated...
March 2017: Cardiac Electrophysiology Clinics
https://www.readbyqxmd.com/read/28167079/anatomy-for-ventricular-tachycardia-ablation-in-structural-heart-disease
#17
REVIEW
Jason S Bradfield, Kalyanam Shivkumar
Ablation of ventricular tachycardia (VT) in the setting of structural heart disease, previously reserved for highly experienced specialized centers, is being performed at more centers internationally as cardiac electrophysiologists gain advanced training. Interventional cardiac electrophysiologists need a high level of anatomic knowledge to guide a procedure that can carry significant risk. Understanding cardiac anatomy improves the chance of procedural success and also the likelihood of appropriate decision making if complications are encountered...
March 2017: Cardiac Electrophysiology Clinics
https://www.readbyqxmd.com/read/28167078/ablation-of-ventricular-tachycardia-in-congenital-and-infiltrative-heart-disease
#18
REVIEW
Adrianus P Wijnmaalen, Katja Zeppenfeld
Radiofrequency catheter ablation (RFCA) is an important treatment modality to prevent ventricular tachycardia (VT) recurrence in patients with repaired congenital heart disease. Identification and ablation of anatomic isthmuses has improved acute ablation outcome with excellent VT-free survival in those with preserved biventricular function. Reports on RFCA for VT in patients with infiltrative disease are sparse and cardiac sarcoidosis seems to be the most prevalent cause for ventricular arrhythmia. Patients with active and ongoing inflammation are at high risk for VT recurrence...
March 2017: Cardiac Electrophysiology Clinics
https://www.readbyqxmd.com/read/28163422/transcatheter-pulmonary-valve-perforation-using-chronic-total-occlusion-wire-in-pulmonary-atresia-with-intact-ventricular-septum
#19
Shweta Bakhru, Shilpa Marathe, Manish Saxena, Sudeep Verma, Rajan Saileela, Tapan K Dash, Nageswara Rao Koneti
BACKGROUND: Perforation of pulmonary valve using radiofrequency ablation in pulmonary atresia with intact ventricular septum (PA IVS) is a treatment of choice. However, significant cost of the equipment limits its utility, especially in the developing economies. OBJECTIVE: To assess the feasibility, safety, and efficacy of perforation of pulmonary valve using chronic total occlusion (CTO) wires in patients with PA IVS as an alternative to radiofrequency ablation...
January 2017: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/28160298/fluoroless-catheter-ablation-of-cardiac-arrhythmias-a-5-year-experience
#20
Mansour Razminia, M Cameron Willoughby, Hany Demo, Hesam Keshmiri, Theodore Wang, Oliver J D'Silva, Terry A Zheutlin, Hakeem Jibawi, Paul Okumale, Richard F Kehoe
BACKGROUND: Catheter ablations have been traditionally performed with the use of fluoroscopic guidance, which exposes the patient and staff to the inherent risks of radiation. We have developed techniques to eliminate the use of fluoroscopy during cardiac ablations and have been performing completely fluoroless catheter ablations on our patients for over 5 years. METHODS: We present a retrospective analysis of the safety, efficacy, and feasibility data from 500 consecutive patients who underwent nonfluoroscopic catheter ablation, targeting a total of 639 arrhythmias, including atrioventricular reciprocating tachycardia (AVRT), atrioventricular nodal reentrant tachycardia (AVNRT), atrial tachycardia (AT), atrial fibrillation (AF), premature ventricular contractions (PVC), and ventricular tachycardia (VT)...
February 3, 2017: Pacing and Clinical Electrophysiology: PACE
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