Nicolas Bertrand, Marc A Gauthier, Céline Bouvet, Pierre Moreau, Anne Petitjean, Jean-Christophe Leroux, Jeanne Leblond
Macromolecular binders consist of polymers, dendrimers, and oligomers with binding properties for endogenous or exogenous substrates. This field, at the frontier of host/guest chemistry and pharmacology, has met a renewed interest in the past decade due to the clinical success of several sequestrants, like sevelamer hydrochloride (Renagel®) or sugammadex (Bridion®). In many instances, multivalent binding by the macromolecular drugs can modify the properties of the substrate, and may prevent it from reaching its site of action and/or trigger a biological response...
October 30, 2011: Journal of Controlled Release