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https://www.readbyqxmd.com/read/27930878/heterogeneity-of-%C3%AE-cells
#1
Shoen Kume
Loss of β-cell mass and function leads to the pathogenesis of type 1 and type 2 diabetes. β-cell neogenesis from endogenous progenitor pools is expected as a potential cell source for the treatment of diabetes. However, the existence of β-cell progenitors was challenged by Dor et al(1) , that self-replication of pre-existing β-cells is the major mechanism for β-cell regeneration. Our knowledge of the pancreatic β-cells would lead to a better understanding and manipulation of the maturation or proliferation of β-cells for regenerative medicine...
December 8, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27928603/-laparoscopic-heller-myotomy-after-failed-poem-and-multiple-balloon-dilatations-better-late-than-never
#2
L Giulini, A Dubecz, H J Stein
BACKGROUND: Despite the lack of long-term results, peroral endoscopic myotomy (POEM) has been increasingly propagated as a feasible alternative to pneumatic balloon dilatation (BD) and laparoscopic Heller myotomy (LHM) in patients with achalasia. After a long-term follow-up, a large percentage of patients reported recurrence of dysphagia. It is unclear which kind of procedure (redo POEM or LHM) should be utilized in these patients with failed POEM. CASE REPORT AND RESULTS: We report the case of a 37-year-old female patient with type I achalasia who was successfully treated with LHM after a failed POEM procedure...
December 7, 2016: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/27923840/osimertinib-for-the-treatment-of-metastatic-epidermal-growth-factor-t970m-positive-non-small-cell-lung-cancer
#3
Sean Khozin, Chana Weinstock, Gideon M Blumenthal, Joyce Cheng, Kun He, Luning Zhuang, Hong Zhao, Rosane Charlab Orbach, Ingrid Fan, Patricia Keegan, Richard Pazdur
On November 13, 2015, FDA granted accelerated approval to osimertinib (TAGRISSO™; AstraZeneca), a breakthrough therapy-designated drug for the treatment of patients with metastatic epidermal growth factor receptor (EGFR) T790M-positive non-small cell lung cancer (NSCLC), as detected by an FDA-approved test, with progression on or after EGFR tyrosine kinase inhibitor therapy. Approval was based on durable tumor response rates in two single-arm, multicenter trials: the dose extension cohort of a first-in-human trial (AURA extension; n=201) and a fixed-dose, activity-estimating trial (AURA2; n=210)...
December 6, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27923591/braf-v600e-mutation-as-a-predictor-of-thyroid-malignancy-in-indeterminate-nodules-a-systematic-review-and-meta-analysis
#4
REVIEW
M Jinih, N Foley, O Osho, L Houlihan, A A Toor, J Z Khan, A A Achakzai, H P Redmond
BACKGROUND: Thyroid nodules are usually diagnosed using fine-needle aspiration (FNA). The sensitivity limitations of FNA result in 10-30% of nodules being classified as "indeterminate". The BRAF(V600E) mutation is associated with papillary thyroid carcinoma (PTC). We conducted a systemic review and meta-analysis to evaluate the diagnostic utility of the BRAF(V600E) mutation in indeterminate nodules. METHOD: PUBMED and EMBASE were searched for studies testing for the BRAF(V600E) involving indeterminate nodules (Thy3a, Thy3f, Thy4) and containing information on final surgical histopathology...
November 22, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27922988/minimally-invasive-fundoplication-is-safe-and-effective-in-patients-with-severe-esophageal-hypomotility
#5
Michael B Goldberg, Abbas El-Sayed Abbas, Michael S Smith, Henry P Parkman, Ron Schey, Daniel T Dempsey
OBJECTIVE: Fundoplication is used to treat refractory gastroesophageal reflux disease (GERD). A subset of patients has coexisting esophageal dysmotility, including aperistalsis or hypoperistalsis. These patients may be at increased risk of dysphagia after fundoplication. To evaluate the outcomes of minimally invasive fundoplication (MIF) in patients with GERD and esophageal hypomotility. METHODS: Retrospective review of all patients who underwent MIF and had severe esophageal hypomotility from January 2003 to June 2013...
December 5, 2016: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/27921376/diagnostic-accuracy-of-serum-cystatin-c-for-the-evaluation-of-renal-dysfunction-in-diabetic-patients-a-meta-analysis
#6
Shi-Kun Yang, Jun Liu, Xian-Ming Zhang, Chun Hu, Wei Zhang, Lin Sun, Hao Zhang
This study aimed to evaluate the diagnostic value of serum cystatin C for renal dysfunction in diabetic patients. Eligible trials were searched from multiple databases, the data were extracted into a 2 × 2 table after the quality assessment of included articles. The pooled sensitivity, specificity and other parameters of accuracy of cystatin C were analyzed using Stata version 12.0. Seventeen studies involving 2173 patients were included. The pooled sensitivity and specificity of serum cystatin C for the diagnosis of renal dysfunction were 0...
December 6, 2016: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/27919588/diagnostic-accuracy-of-the-berlin-questionnaire-stop-bang-stop-and-epworth-sleepiness-scale-in-detecting-obstructive-sleep-apnea-a-bivariate-meta-analysis
#7
REVIEW
Hsiao-Yean Chiu, Pin-Yuan Chen, Li-Pang Chuang, Ning-Hung Chen, Yu-Kang Tu, Yu-Jung Hsieh, Yu-Chi Wang, Christian Guilleminault
Obstructive sleep apnea (OSA) is a highly prevalent sleep disorder; however, it remains underdiagnosed and undertreated. Although screening tools such as the Berlin questionnaire (BQ), STOP-BANG questionnaire (SBQ), STOP questionnaire (STOP), and Epworth sleepiness scale (ESS) are widely used for OSA, the findings regarding their diagnostic accuracy are controversial. Therefore, this meta-analysis investigated and compared the summary sensitivity, specificity, and diagnostic odds ratio (DOR) among the BQ, SBQ, STOP, and ESS according to the severity of OSA...
November 5, 2016: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/27918702/are-immigrants-more-physically-active-than-native-born-australians-and-does-it-changes-over-time-evidence-from-nationally-representative-longitudinal-survey
#8
Suresh Joshi, Santosh Jatrana, Yin Paradies
BACKGROUND: We investigated the differences and over time changes in recommended physical activity among foreign-born (FB) from English speaking countries (ESC) and non-English speaking countries (NESC) relative to native-born (NB) Australians, and whether the association between nativity and duration of residence (DoR) and physical activity is mediated by English language proficiency, socio-economic status and social engagement/membership. METHODS: This study applies multilevel group-mean-centred mixed (hybrid) logistic regression models to twelve waves of longitudinal data (12,634 individuals) from the Household, Income and Labour Dynamics in Australia survey with engagement in physical activities for more than three times a week as the outcome variable...
December 5, 2016: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/27914241/engot-ov-6-trinova-2-randomised-double-blind-phase-3-study-of-pegylated-liposomal-doxorubicin-plus-trebananib-or-placebo-in-women-with-recurrent-partially-platinum-sensitive-or-resistant-ovarian-cancer
#9
Christian Marth, Ignace Vergote, Giovanni Scambia, Willi Oberaigner, Andrew Clamp, Regina Berger, Christian Kurzeder, Nicoletta Colombo, Peter Vuylsteke, Domenica Lorusso, Marcia Hall, Vincent Renard, Sandro Pignata, Rebecca Kristeleit, Sevilay Altintas, Gordon Rustin, Robert M Wenham, Mansoor Raza Mirza, Peter C Fong, Amit Oza, Bradley J Monk, Haijun Ma, Florian D Vogl, Bruce A Bach
AIMS: Trebananib, a peptide-Fc fusion protein, inhibits angiogenesis by inhibiting binding of angiopoietin-1/2 to the receptor tyrosine kinase Tie2. This randomised, double-blind, placebo-controlled phase 3 study evaluated whether trebananib plus pegylated liposomal doxorubicin (PLD) improved progression-free survival (PFS) in patients with recurrent epithelial ovarian cancer. METHODS: Women with recurrent ovarian cancer (platinum-free interval ≤12 months) were randomised to intravenous PLD 50 mg/m(2) once every 4 weeks plus weekly intravenous trebananib 15 mg/kg or placebo...
November 30, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27909790/strigolactones-affect-tomato-hormone-profile-and-somatic-embryogenesis
#10
Yuanli Wu, Evgenia Dor, Joseph Hershenhorn
Exogenously applied GR24 affected somatic embryo formation and morphogenesis of strigolactone-deficient tomato mutant through cross-talk with auxins and cytokinins indicating involvement of SLs in the embryogenic process. Strigolactones (SLs) mediate the regulation of plant responses to the environment through cross-talk with other plant hormones, especially auxins. Auxins play a crucial role in coordinating the morphogenesis and development of plant reproductive organs, including the signal-transduction cascade leading to the reprogramming of gene-expression patterns before embryo formation...
December 1, 2016: Planta
https://www.readbyqxmd.com/read/27906998/explaining-the-decline-in-coronary-heart-disease-mortality-in-the-netherlands-between-1997-and-2007
#11
Carla Koopman, Ilonca Vaartjes, Ineke van Dis, W M Monique Verschuren, Peter Engelfriet, Edith M Heintjes, Anneke Blokstra, Dorly J H Deeg, Marjolein Visser, Michiel L Bots, Martin O'Flaherty, Simon Capewell
OBJECTIVE: We set out to determine what proportion of the mortality decline from 1997 to 2007 in coronary heart disease (CHD) in the Netherlands could be attributed to advances in medical treatment and to improvements in population-wide cardiovascular risk factors. METHODS: We used the IMPACT-SEC model. Nationwide information was obtained on changes between 1997 and 2007 in the use of 42 treatments and in cardiovascular risk factor levels in adults, aged 25 or over...
2016: PloS One
https://www.readbyqxmd.com/read/27906823/the-transplantation-journal-on-social-media-the-transplantjrnl-journey-from-impact-factor-to-klout-score
#12
Carla C Baan, Frank J M F Dor
No abstract text is available yet for this article.
December 1, 2016: Transplantation
https://www.readbyqxmd.com/read/27904660/comparison-of-mri-ct-and-18f-fdg-pet-ct-in-the-diagnosis-of-local-and-metastatic-of-nasopharyngeal-carcinomas-an-updated-meta-analysis-of-clinical-studies
#13
Wang-Sheng Chen, Jian-Jun Li, Lan Hong, Zeng-Bao Xing, Fen Wang, Chang-Qing Li
BACKGROUND: A meta-analysis was conducted to evaluate the accuracy of MRI, CT and FDG PET/CT in TNM stage of nasopharyngeal carcinoma patients (NPC). METHODS: Through a search of studies from 1996 to April 2015, pooled estimated sensitivity, specificity, pooled diagnostic odds ratio (DOR), summary receiver operating characteristic (SROC) curves and Q*-index were calculated. RESULTS: Totally 23 studies were included for analysis. In T stage, the pooled sensitivity, specificity, DOR and SROC of MRI were 0...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27902616/diagnostic-accuracy-of-tumor-necrosis-factor-alpha-assay-for-tuberculous-pleurisy-a-prisma-compliant-meta-analysis
#14
Min Li, Zhuang Luo, Wenye Zhu, Rana Sami Ullah Khan, Saeed Ummai Ummair, Shaoqing Shi
BACKGROUND: The diagnosis of tuberculous pleurisy is difficult and traditional methods are not always helpful. Many studies have focused on the tumor necrosis factor-alpha (TNF-α) assay in pleural effusion for the diagnosis of tuberculous pleurisy, but the results remain controversial. This meta-analysis was conducted to determine the overall diagnostic accuracy of TNF-α. METHODS: Relevant studies were searched from PubMed, Embase, Web of Science, Chinese National Knowledge Infrastructure (CNKI), Wangfang, and Weipu...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27901639/results-of-laparoscopic-heller-s-myotomy-for-achalasia-in-children-a-systematic-review-of-the-literature
#15
Maurizio Pacilli, Mark Davenport
INTRODUCTION: Achalasia is a rare disorder in children who are commonly treated by laparoscopic Heller's myotomy (LHM). However, there are no large studies evaluating the results of LHM in the pediatric population, and the need of a concomitant fundoplication remains unclear. The aim of the study is to appraise the results of LHM based on a systematic literature review. MATERIALS AND METHODS: MEDLINE search of the English literature was performed for "achalasia," "children," "laparoscopy," "Heller," "myotomy," and "cardiomyotomy...
November 30, 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/27896796/development-and-validation-of-a-frailty-index-in-the-longitudinal-aging-study-amsterdam
#16
Emiel O Hoogendijk, Olga Theou, Kenneth Rockwood, Bregje D Onwuteaka-Philipsen, Dorly J H Deeg, Martijn Huisman
BACKGROUND: Frailty is a state of increased vulnerability to adverse outcomes. The frailty index (FI), defined by the deficit accumulation approach, is a sensitive instrument to measure levels of frailty, and therefore important for longitudinal studies of aging. AIMS: To develop an FI in the Longitudinal Aging Study Amsterdam (LASA), and to examine the predictive validity of this FI for 19-year mortality. METHODS: LASA is an ongoing study among Dutch older adults, based on a nationally representative sample...
November 28, 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27893656/is-it-feasible-to-detect-epidermal-growth-factor-receptor-mutations-in-circulating-tumor-cells-in-nonsmall-cell-lung-cancer-a-meta-analysis
#17
Yafang Liu, Ze Xing, Ping Zhan, Hongbing Liu, Wei Ye, Tangfeng Lv, Yong Song
BACKGROUND: The value of circulating tumor cells (CTCs) in detecting epidermal growth factor receptor (EGFR) mutations in patients with nonsmall cell lung cancer (NSCLC) is controversial. We performed a meta-analysis to investigate the diagnostic significance of CTCs with tumor tissues as the standard control. METHODS: A systematic literature search, including papers published until November 26, 2015, was performed using PubMed, Medline, Embase, Web of Science, and the China National Knowledge Infrastructure, and the references of retrieved articles were screened...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27891091/amyloid-plaques-in-retina-for-diagnosis-in-alzheimer-s-patients-a-meta-analysis
#18
Jiangling Jiang, Hongyan Wang, Wei Li, Xinyi Cao, Chunbo Li
Background: Detection of retinal β-amyloid (Aβ) peptide accumulation is a novel diagnostic method for Alzheimer's disease (AD), but there is, as yet, no conclusive evidence of its accuracy. Aim: To identify the diagnostic accuracy of pathological retinal Aβ detection for AD by a meta-analytic approach. Methods: Electronic and reference searches were conducted to identify studies related to the diagnostic effects of retinal Aβ detection in AD that met pre-defined inclusion criteria. The QUADAS-2 tool was employed to assess the risk of bias, and Review Manager plus the Open Meta-Analyst were used to perform the data analysis...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27889507/cyp2c9-genotypes-modify-benzodiazepine-related-fall-risk-original-results-from-three-studies-with-meta-analysis
#19
Annelies C Ham, Gijsbertus Ziere, Linda Broer, Karin M A Swart, Anke W Enneman, Suzanne C van Dijk, Janneke P van Wijngaarden, Nikita L van der Zwaluw, Elske M Brouwer-Brolsma, Rosalie A M Dhonukshe-Rutten, Natasja M van Schoor, M Carola Zillikens, Teun van Gelder, Oscar J de Vries, Paul Lips, Dorly J H Deeg, Lisette C P G M de Groot, Albert Hofman, Renger F Witkamp, André G Uitterlinden, Bruno H Stricker, Nathalie van der Velde
OBJECTIVE: To investigate whether the CYP2C9*2 and *3 variants modify benzodiazepine-related fall risk. DESIGN: Three prospective studies; the Rotterdam Study, B-PROOF, and LASA. SETTING: Community-dwelling individuals living in or near five Dutch cities. PARTICIPANTS: There were 11,485 participants aged ≥55 years. MEASUREMENTS: Fall incidents were recorded prospectively. Benzodiazepine use was determined using pharmacy dispensing records or interviews...
November 23, 2016: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/27882918/hyperglycaemia-induces-metabolic-dysfunction-and-glycogen-accumulation-in-pancreatic-%C3%AE-cells
#20
Melissa F Brereton, Maria Rohm, Kenju Shimomura, Christian Holland, Sharona Tornovsky-Babeay, Daniela Dadon, Michaela Iberl, Margarita V Chibalina, Sheena Lee, Benjamin Glaser, Yuval Dor, Patrik Rorsman, Anne Clark, Frances M Ashcroft
Insulin secretion from pancreatic β-cells is impaired in all forms of diabetes. The resultant hyperglycaemia has deleterious effects on many tissues, including β-cells. Here we show that chronic hyperglycaemia impairs glucose metabolism and alters expression of metabolic genes in pancreatic islets. In a mouse model of human neonatal diabetes, hyperglycaemia results in marked glycogen accumulation, and increased apoptosis in β-cells. Sulphonylurea therapy rapidly normalizes blood glucose levels, dissipates glycogen stores, increases autophagy and restores β-cell metabolism...
November 24, 2016: Nature Communications
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