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https://www.readbyqxmd.com/read/29786050/diagnostic-performance-of-intestinal-fusobacterium-nucleatum-in-colorectal-cancer-a-meta-analysis
#1
Bo-Jian Peng, Chuang-Yu Cao, Wei Li, Yong-Jian Zhou, Yuan Zhang, Yu-Qiang Nie, Yan-Wen Cao, Yu-Yuan Li
Background: Increasing evidence has supported the link of intestinal Fusobacterium nucleatum infection to colorectal cancer (CRC). However, the value of F. nucleatum as a biomarker in CRC detection has not been fully defined. In order to reduce the random error and bias of individual research, this meta-analysis aimed to evaluate the diagnostic performance of intestinal F. nucleatum in CRC patients and provide evidence-based data to clinical practice. Methods: An article search was performed from PubMed, Embase, Cochrane Library, and Web of Science databases up to December 2017, using the following key words: "Fusobacterium nucleatum", "Fusobacterium spp...
June 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29783129/effect-of-surfactant-assisted-sonic-pretreatment-on-liquefaction-of-fruits-and-vegetable-residue-characterization-acidogenesis-biomethane-yield-and-energy-ratio
#2
M Shanthi, J Rajesh Banu, P Sivashanmugam
The present study explored the disintegration potential of fruits and vegetable residue through sodium dodecyl sulphate (SDS) assisted sonic pretreatment (SSP). In SSP method, initially the biomass barrier (lignin) was removed using SDS at different dosage, subsequently it was sonically disintegrated. The effect of SSP were assessed based on dissolved organic release (DOR) of fruits and vegetable waste and specific energy input. SSP method achieved higher DOR rate and suspended solids reduction (26% and 16%) at optimum SDS dosage of 0...
May 15, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29780624/diagnostic-performance-of-fluorine-18-fluorodeoxyglucose-positron-emission-tomography-in-the-management-of-solitary-pulmonary-nodule-a-meta-analysis
#3
Duilio Divisi, Mirko Barone, Luca Bertolaccini, Gino Zaccagna, Francesca Gabriele, Roberto Crisci
Background: In the setting of solitary pulmonary nodules (SPNs), fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG-PET/CT) is considered a useful non-invasive diagnostic tool though false positive (FP) and false negative (FN) results affects accuracy due to different conditions, such as inflammatory diseases or low-uptake neoplasms. Aim of this study is to evaluate overall diagnostic performance of 18 F-FDG-PET/CT for malignant pulmonary nodules...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29779230/role-of-mu-but-not-delta-or-kappa-opioid-receptors-in-context-induced-reinstatement-of-oxycodone-seeking
#4
Jennifer M Bossert, Jennifer K Hoots, Ida Fredriksson, Sweta Adhikary, Michelle Zhang, Marco Venniro, Yavin Shaham
Relapse to nonmedical use of prescription opioids often occurs after exposure to places previously associated with drug use. Here, we describe a rat model of context-induced reinstatement of oxycodone seeking after repeated cycles of drug self-administration and extinction-induced abstinence. We also determined the role of mu, delta, and kappa opioid receptors (MOR, DOR, KOR) in this reinstatement. We trained rats to self-administer oxycodone for 6 h/d in Context A; lever pressing was paired with a discrete cue...
May 19, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29778639/sarc-f-for-screening-of-sarcopenia-among-older-adults-a-meta-analysis-of-screening-test-accuracy
#5
Satoshi Ida, Ryutaro Kaneko, Kazuya Murata
OBJECTIVE: To examine the screening ability of SARC-F for older adults using a meta-analysis. DESIGN: Meta-analysis. SETTING AND PARTICIPANTS: The literature review was conducted using MEDLINE, Cochrane Database of Systematic Reviews, and ClinicalTrials.gov. Articles written on and after 1960 that included data regarding the sensitivity and specificity of SARC-F's diagnostic criteria for sarcopenia in older adults were searched. MEASURES: The bivariate random effects model was used to calculate the summary estimates of sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR)...
May 16, 2018: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29773321/evaluating-scenarios-of-locations-and-capacities-for-vaccine-storage-in-nigeria
#6
Dor Hirsh Bar Gai, Zachary Graybill, Paule Voevodsky, Ekundayo Shittu
Many developing countries still face the prevalence of preventable childhood diseases because their vaccine supply chain systems are inadequate by design or structure to meet the needs of their populations. Currently, Nigeria is evaluating options in the redesign of the country's vaccine supply chain. Using Nigeria as a case study, the objective is to evaluate different regional supply chain scenarios to identify the cost minimizing optimal hub locations and storage capacities for doses of different vaccines to achieve a 100% fill rate...
May 14, 2018: Vaccine
https://www.readbyqxmd.com/read/29771090/-the-role-of-%C3%A2-%C3%A2-f-fdg-pet-ct-for-detecting-nodal-metastases-in-cn0-head-neck-cancer-patients%C3%AF-a-meta-analysis
#7
X Y Li, C L Sun, X D Du
Objective: The aim of this study is to evaluate the accuracy of ¹⁸F-fluorodeoxyglucose PET/CT(¹⁸F-FDG PET/CT) for the diagnosis of cervical node metastases in cN0 head neck cancer patients. Method: An electronic database search(PubMed,EMBASE,Cochrane Library,WanFang and CNKI databases)was performed. Updated quality assessment of diagnostic accuracy studies-2(QUADAS-2) was used to assess study quality. Data analyses were performed with Meta-Disc1.4. Result: Eight studies were included in the present Meta-analysis...
May 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29768927/ultrasonographic-optic-nerve-sheath-diameter-to-detect-increased-intracranial-pressure-in-adults-a-meta-analysis
#8
Sung-Eun Kim, Eun Pyo Hong, Heung Cheol Kim, Si Un Lee, Jin Pyeong Jeon
Background The optimal optic nerve sheath diameter (ONSD) cut-off for identifying increased intracranial pressure (IICP) remains unclear in adult patients. Purpose To validate the diagnostic accuracy of ultrasonographic (US) ONSD > 5.0 mm as a cut-off for detecting IICP by computed tomographic (CT) through a meta-analysis. Material and Methods A systemic literature review was performed of online databases from January 1990 to September 2017. A bivariate random-effects model was used to estimate pooled sensitivity, specificity, and diagnostic odds ratio (DOR) with 95% confidence intervals (CIs)...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29768368/meta-analysis-of-computed-tomography-angiography-versus-magnetic-resonance-angiography-for-intracranial-aneurysm
#9
Xiaodan Chen, Yun Liu, Huazhang Tong, Yonghai Dong, Dongyang Ma, Lei Xu, Cheng Yang
BACKGROUND: Whether the diagnosis value of computed tomography angiography (CTA) for intracranial aneurysm is in accordance with magnetic resonance angiography (MRA) remains inconclusive. This meta-analysis aims to synthesize relevant studies to compare the diagnostic efficacies of the 2 methods. METHODS: Potentially relevant studies were selected through PubMed, Embase, Wanfang, Chongqing VIP, and China National Knowledge Infrastructure databases by using the core terms "computer tomography angiography" (CTA) and "magnetic resonance angiography" (MRA) and "intracranial aneurysm*" in the titles, abstracts, and keywords of the articles...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29768254/neuroprotection-against-hypoxic-ischemic-injury-%C3%AE-opioid-receptors-and-bdnf-trkb-pathway
#10
Shiying Sheng, Jingzhong Huang, Yi Ren, Feng Zhi, Xuansong Tian, Guoqiang Wen, Guanghong Ding, Terry C Xia, Fei Hua, Ying Xia
The delta-opioid receptor (DOR) is one of three classic opioid receptors in the opioid system. It was traditionally thought to be primarily involved in modulating the transmission of messages along pain signaling pathway. Although there were scattered studies on its other neural functions, inconsistent results and contradicting conclusions were found in past literatures, especially in terms of DOR's role in a hypoxic/ischemic brain. Taking inspiration from the finding that the turtle brain exhibits a higher DOR density and greater tolerance to hypoxic/ischemic insult than the mammalian brain, we clarified DOR's specific role in the brain against hypoxic/ischemic injury and reconciled previous controversies in this aspect...
May 11, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29761614/diagnostic-value-of-nailfold-videocapillaroscopy-in-systemic-sclerosis-secondary-pulmonary-arterial-hypertension-a-meta-analysis
#11
Zhongbin Xia, Guiping Wang, Huashi Xiao, Shanshan Guo, Ying Liu, Fanru Meng, Dan Liu, Guoqing Li, Liang Zong
BACKGROUND: Microvascular changes play a decisive role in systemic sclerosis (SSc) and occur early in the course of the disease. Pulmonary arterial hypertension (PAH) represents one of the main clinical expressions of the vascular changes in SSc, and the abnormal changes especially capillary density and capillary width are detectable at nailfold videocapillaroscopy (NVC). AIM: The aim of this meta-analysis was to investigate the differences in capillary nailfold changes in SSc patients with and without PAH, and to estimate the early diagnostic value of NVC in systemic sclerosis secondary pulmonary arterial hypertension (SSc-PAH)...
May 15, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29761272/primary-paraesophageal-hernia-repair-with-gore%C3%A2-bio-a%C3%A2-tissue-reinforcement-long-term-outcomes-and-association-of-bmi-and-recurrence
#12
Michael T Olson, Saurabh Singhal, Roshan Panchanathan, Sreeja Biswas Roy, Paul Kang, Taylor Ipsen, Sumeet K Mittal, Jasmine L Huang, Michael A Smith, Ross M Bremner
BACKGROUND: Laparoscopic repair remains the gold-standard treatment for paraesophageal hernia (PEH). We analyzed long-term symptomatic outcomes and surgical reintervention rates after primary PEH repair with onlay synthetic bioabsorbable mesh (W. L. Gore & Associates, Inc., Flagstaff, AZ) and examined body mass index (BMI) as a possible risk factor for poor outcomes and for recurrence. METHODS: We queried a prospectively maintained database to identify patients who underwent laparoscopic primary PEH repair with onlay patch of a bioprosthetic absorbable mesh (Bio-A® Gore®) between 05/28/2009 and 12/31/2013...
May 14, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29760801/diagnostic-and-prognostic-value-of-microrna-628-for-cancers
#13
Jing-Hua Li, Shan-Shan Sun, Chang-Jin Fu, An-Qi Zhang, Chen Wang, Rong Xu, Shu-Yang Xie, Ping-Yu Wang
Background: Many studies manifested miRNA-628 (miR-628) was deregulated in various cancers, indicating that miR-628 might serve as a novel biomarker of cancer diagnosis and prognosis, but it's role was still uncertain. This study aimed to evaluate the value of miR-628 in various cancers for diagnosis and prognosis, as well as its predictive power in combination biomarkers. Materials and Methods: A literature search was performed using Medline (via PubMed), Embase, Web of Science databases, and Ovid platform up to November 2017...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29758576/-mental-health-stigma-an-influencing-factor-in-healthcare-utilization-by-veterans-of-the-german-armed-forces
#14
Katrin Schuy, Loni M Brants, Simone Dors, Andreas Ströhle, Peter Lutz Zimmermann, Gerd Dieter Willmund, Heinrich Rau, Stefan Siegel
THEORETICAL BACKGROUND AND OBJECTIVE OF THE STUDY:  Mental illness stigma is a barrier to healthcare utilization. This study is the first to research the connection between mental illness stigma and the use of healthcare by veterans of the German Armed Forces. An overview of perceived stigma components in this sample is provided that should help understand how these factors influence healthcare utilization. METHODS:  43 interviews with veterans of the German Armed Forces were conducted...
May 14, 2018: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29758503/mri-and-pet-ct-for-evaluation-of-the-pathological-response-to-neoadjuvant-chemotherapy-in-breast-cancer-a-systematic-review-and-meta-analysis
#15
REVIEW
Huimin Li, Liang Yao, Penghui Jin, Lidong Hu, Xiaofei Li, Tiankang Guo, Kehu Yang
BACKGROUND: Neoadjuvant chemotherapy (NAC) has become an essential treatment for breast cancer. However, there is still no consensus on the best tool to evaluate pathological response to NAC. METHODS: Two reviewers systematically searched Cochrane, PubMed, EMBASE, Web of Science, and CBM (last updated in February 2017) for eligible articles. We independently screened and selected studies that conformed to the inclusion criteria and extracted the requisite data. Pooled sensitivity, specificity, and the area under the SROC curve were calculated to estimate the diagnostic accuracy of magnetic resonance imaging (MRI) and positron emission computed tomography (PET/CT)...
May 11, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29758242/diagnostic-accuracy-of-nucleic-acid-amplification-based-assays-for-tuberculous-meningitis-a-meta-analysis
#16
Renu Gupta, Puneet Talwar, Pumanshi Talwar, Sarbjeet Khurana, Suman Kushwaha, Nupur Jalan, Rajeev Thakur
BACKGROUND: Numerous in-house and commercial nucleic acid amplification tests (NAAT) have been evaluated using variable reference standards for diagnosis of TBM but their diagnostic potential is still not very clear. METHODS: We conducted a meta-analysis to assess the diagnostic accuracy of different NAAT based assays for diagnosing TBM against 43 data sets of confirmed TBM (n=1066) and 61 data sets of suspected TBM (n=3721) as two reference standards. The summary estimate of the sensitivity and the specificity were obtained using the bivariate model...
May 11, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29752949/the-change-of-nuclear-lc3-distribution-in-acute-myeloid-leukemia-cells
#17
Guo Wenjian, Jin Jingrui, Pan Jiajia, Yao Rongxing, Li Xia, Huang Xin, Ma Zhixing, Huang Sujuan, Yan Xiao, Jin Jie, Dong Aishu
Making sure the change of nuclear LC3 distribution in the autophagy of acute myeloid leukemia (AML) cell and finding out the regulation mechanism may lead to a breakthrough for killing AML cells. Western blots were performed to assess the expression of autophagy proteins. Changes in the LC3 distribution were monitored by immunofluorescence assays together with western blots, and the expression levels of Sirt1, DOR, Beclin1, HMGB1, and AMPK mRNA were detected via fluorescent quantitative PCR. The effects of Sirt1 and DOR on cell proliferation and survival were analyzed by MTT, flow cytometry, and western blotting assays...
May 9, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29752332/prolonged-duration-of-response-in-lenvatinib-responders-with-thyroid-cancer
#18
Andrew G Gianoukakis, Corina E Dutcus, Nicolas Batty, Matthew Guo, Mahadi Baig
We present an updated analysis of lenvatinib in radioiodine-refractory differentiated thyroid cancer (RR-DTC) with new duration of response (DOR) data unavailable for the primary analysis. In this randomized, double-blind, multicenter, placebo-controlled phase 3 study, patients ≥18 years old with measurable, pathologically confirmed RR-DTC with independent radiologic confirmation of disease progression within the previous 13 months were randomized 2:1 to oral lenvatinib 24 mg/day or placebo. The main outcome measures for this analysis are DOR and progression-free survival (PFS)...
June 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29748324/separation-of-enantiomers-by-their-enantiospecific-interaction-with-achiral-magnetic-substrates
#19
Koyel Banerjee-Ghosh, Oren Ben Dor, Francesco Tassinari, Eyal Capua, Shira Yochelis, Amir Capua, See-Hun Yang, Stuart S P Parkin, Soumyajit Sarkar, Leeor Kronik, Lech Tomasz Baczewski, Ron Naaman, Yossi Paltiel
It is commonly assumed that recognition and discrimination of chirality, both in nature and in artificial systems, depend solely on spatial effects. However, recent studies have suggested that charge redistribution in chiral molecules manifests an enantiospecific preference in electron spin orientation. We therefore reasoned that the induced spin polarization may affect enantiorecognition through exchange interactions. Here, we show experimentally that the interaction of chiral molecules with a perpendicularly magnetized substrate is enantiospecific...
May 10, 2018: Science
https://www.readbyqxmd.com/read/29739083/detection-performance-of-circulating-microrna-210-for-renal-cell-carcinoma-a-meta-analysis
#20
Yan Chen, Xiaoyan Wang, Xuxiao Zhu, Shengwen Shao
BACKGROUND: Renal cell carcinoma (RCC) is the most common neoplasm of the adult kidney. miR-210 was a known oncogene with tumor-promoting effects in many types of cancer. This meta-analysis aimed to evaluate the potential diagnostic value of circulating miR-210. METHODS: Relevant literature was collected from PubMed and Embase. Sensitivity, specificity, and diagnostic odds ratio (DOR) for miR-210 in the diagnosis of RCC were pooled using random effects models. Summary receiver operating characteristic (SROC) curve analysis and the area under the curve (AUC) were used to estimate the overall test performance...
April 1, 2018: Clinical Laboratory
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