keyword
MENU ▼
Read by QxMD icon Read
search

Dor

keyword
https://www.readbyqxmd.com/read/29329189/beta-cell-death-by-cell-free-dna-and-outcome-after-clinical-islet-transplantation
#1
Boris L Gala-Lopez, Daniel Neiman, Tatsuya Kin, Doug O'Gorman, Andrew R Pepper, Andrew J Malcolm, Sheina Pianzin, Peter A Senior, Patricia Campbell, Benjamin Glaser, Yuval Dor, Ruth Shemer, A M James Shapiro
BACKGROUND: Optimizing engraftment and early survival after clinical islet transplantation is critical to long-term function, but there are no reliable, quantifiable measures to assess beta cell death. Circulating cell free DNA (cfDNA) derived from beta cells has been identified as a novel biomarker to detect cell loss, and was recently validated in new-onset type 1 diabetes and in islet transplant patients. METHODS: Herein we report beta cell cfDNA measurements after allotransplantation in 37 subjects and the correlation with clinical outcomes...
January 11, 2018: Transplantation
https://www.readbyqxmd.com/read/29327944/diagnostic-accuracy-of-f-18-fdg-pet-or-pet-ct-for-the-characterization-of-adrenal-masses-a-systematic-review-and-meta-analysis
#2
Seong-Jang Kim, Sang Woo Lee, Kyoungjune Pak, In-Ju Kim, Keunyoug Kim
OBJECTIVE: We aimed to explore the role of the diagnostic accuracy of F-18 fluorodeoxyglucose positron emission tomography (F-18 FDG PET) or positron emission tomography/computed tomography (PET/CT) for characterization of adrenal lesions through a systematic review and meta-analysis. METHODS: The MEDLINE, EMBASE, and Cochrane Library database, from the earliest available date of indexing through April 30, 2017, were searched for studies evaluating the diagnostic performance of F-18 FDG PET or PET/CT for characterization of adrenal lesions...
January 12, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29327725/whole-genome-sequencing-reveals-principles-of-brain-retrotransposition-in-neurodevelopmental-disorders
#3
Jasmine Jacob-Hirsch, Eran Eyal, Binyamin A Knisbacher, Jonathan Roth, Karen Cesarkas, Chen Dor, Sarit Farage-Barhom, Vered Kunik, Amos J Simon, Moran Gal, Michal Yalon, Sharon Moshitch-Moshkovitz, Rick Tearle, Shlomi Constantini, Erez Y Levanon, Ninette Amariglio, Gideon Rechavi
Neural progenitor cells undergo somatic retrotransposition events, mainly involving L1 elements, which can be potentially deleterious. Here, we analyze the whole genomes of 20 brain samples and 80 non-brain samples, and characterized the retrotransposition landscape of patients affected by a variety of neurodevelopmental disorders including Rett syndrome, tuberous sclerosis, ataxia-telangiectasia and autism. We report that the number of retrotranspositions in brain tissues is higher than that observed in non-brain samples and even higher in pathologic vs normal brains...
January 12, 2018: Cell Research
https://www.readbyqxmd.com/read/29325458/a-diagnostic-test-accuracy-meta-analysis-of-maternal-serum-ischemia-modified-albumin-for-detection-of-preeclampsia
#4
Varikasuvu Seshadri Reddy, Munikumar Manne, Pragathi Duggina, Neelakant Varma
BACKGROUND/AIMS: Ischemia-modified albumin (IMA) has been widely accepted as a serological biomarker. IMA has been proposed as a simple and novel marker of oxidative stress in preeclampsia (PE). This systematic review and diagnostic test accuracy meta-analysis aims to evaluate the diagnostic accuracy of this novel serological biomarker, IMA to detect PE. METHODS: A systematic search of major databases was performed to identify all published diagnostic accuracy studies on IMA...
January 11, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29324390/nfat-1-hyper-activation-by-methionine-enkephalin-menk-significantly-induces-cell-apoptosis-of-rats-c6-glioma-in-vivo-and-in-vitro
#5
Wei-Cheng Lu, Hui Xie, Xin-Xin Tie, Ruizhe Wang, An-Hua Wu, Feng-Ping Shan
The aim of the work was to investigate the effect and possible mechanism of MENK on the growth of rat C6 glioma in vivo or in vitro. Our findings showed that MENK could inhibit the growth of rat C6 glioma, prolong median survival times in tumor-bearing rats, and induce glioma cell apoptosis. Moreover, MENK could increase the activities of caspase-3, caspase-8 and caspase-9. It also increased the expression of Fas, FasL, Bax, while decreased the expression of Bcl-2. We further confirmed that MENK could increase opioid receptors MOR and DOR expressions, Ca2+ influx into the cytoplasm, and a substantial increase of NFAT1accumulation in the nuclei in C6 glioma cell...
January 8, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29321524/phenotypic-divergence-despite-low-genetic-differentiation-in-house-sparrow-populations
#6
Shachar Ben Cohen, Roi Dor
Studying patterns of phenotypic variation among populations can shed light on the drivers of evolutionary processes. The house sparrow (Passer domesticus) is one of the world's most ubiquitous bird species, as well as a successful invader. We investigated phenotypic variation in house sparrow populations across a climatic gradient and in relation to a possible scenario of an invasion. We measured variation in morphological, coloration, and behavioral traits (exploratory behavior and neophobia) and compared it to the neutral genetic variation...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29306118/diagnostic-accuracy-of-radiology-ct-x-ray-us-for-predicting-difficult-intubation-in-adults-a-meta-analysis
#7
REVIEW
Chao Ji, Qiang Ni, Wurong Chen
OBJECTIVE: The aim of this study was to evaluate the overall accuracy of radiological measurements in prediction of difficult airway and compare the diagnostic value between the radiological measurements and the modified Mallampati score through a meta-analysis of published studies. METHODS: A comprehensive electronic search of related literature was performed in PubMed, Embase, Cochrane Library and China National Knowledge Infrastructure. Meta-DiSc 1.4 and STATA 12...
January 3, 2018: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/29303806/no-gains-in-long-term-survival-after-liver-transplantation-over-the-past-three-decades
#8
Abbas Rana, Ruth L Ackah, Gwilym J Webb, Karim J Halazun, John M Vierling, Hao Liu, Meng-Fen Wu, Dor Yoeli, Michael Kueht, Ayse L Mindikoglu, Norman L Sussman, Nhu T Galván, Ronald T Cotton, Christine A O'Mahony, John A Goss
OBJECTIVE: The aim of this study was to assess improvements in long-term survival after liver transplant by analyzing outcomes in transplant recipients who survived beyond 1 year. SUMMARY OF BACKGROUND DATA: Gains in short-term survival following liver transplantation have been gratifying. One-year survival in 1986 was 66% improved to over 92% in 2015. However, little is known about why long-term has not seen similar success. METHODS: We analyzed 111,568 recipients from 1987 to 2016 using the Kaplan-Meier method for time-to-event analysis and multivariable Cox regression...
January 4, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29298478/influence-of-intermolecular-coupling-on-the-vibrational-spectrum-of-water
#9
Sarah M Matt, Dor Ben-Amotz
Raman multivariate curve resolution (Raman-MCR) spectra obtained from pure and isotopically dilute water are used to probe the influence of intermolecular resonance couplings on water OH and OD stretch band shapes and intensities, in the absence of intramolecular coupling. Intermolecular resonant coupling is found to broaden and red-shift the stretch band of water, in qualitative agreement with the predictions of Yang and Skinner. The influence of intermolecular coupling is found to increase with decreasing temperature, and to increase the Raman scattering cross section of the OH stretch, but decrease the OD stretch cross section...
January 3, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29284202/pembrolizumab-in-asia-pacific-patients-with-advanced-head-and-neck-squamous-cell-carcinoma-analyses-from-keynote-012
#10
Makoto Tahara, Kei Muro, Yasuhisa Hasegawa, Hyun Cheol Chung, Chia-Chi Lin, Bhumsuk Keam, Kenichi Takahashi, Jonathan D Cheng, Yung-Jue Bang
KEYNOTE-012 was a phase Ib, multicohort study designed to investigate efficacy and safety of pembrolizumab in advanced solid tumors. Results from the subset of patients with recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) from the Asia-Pacific region are reported. Patients with recurrent/metastatic HNSCC, measurable disease (Response Evaluation Criteria in Solid Tumors, version 1.1 [RECIST v1.1]), and Eastern Cooperative Oncology Group performance status (ECOG PS) 0-1 were eligible for enrollment in the HNSCC expansion cohort...
December 28, 2017: Cancer Science
https://www.readbyqxmd.com/read/29278880/hypermethylation-pattern-of-esr-and-pgr-genes-and-lacking-estrogen-and-progesterone-receptors-in-human-breast-cancer-tumors-er-pr-subtypes
#11
Saeed Pirouzpanah, Forough-Azam Taleban, Parvin Mehdipour, Siamak Sabour, Morteza Atri
BACKGROUND: The option of endocrine therapy in breast cancer remains conventionally promising. OBJECTIVE: We aimed to investigate how accurately the pattern of hypermethylation at estrogen receptor (ESR) and progesterone receptor (PgR) genes may associate with relative expression and protein status of ER, PR and the combinative phenotype of ER/PR. METHODS: In this consecutive case-series, we enrolled 139 primary diagnosed breast cancer. Methylation specific PCR was used to assess the methylation status (individual test)...
December 15, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29273824/accuracy-of-the-third-molar-maturity-index-in-assessing-the-legal-age-of-18%C3%A2-years-a-systematic-review-and-meta-analysis
#12
Bianca Marques Santiago, Leopoldina Almeida, Yuri Wanderley Cavalcanti, Marcela Baraúna Magno, Lucianne Cople Maia
The age estimation is a complex procedure required in the daily practice of legal medicine. The maturity of third molars stands out by the age of 18 because these teeth are still in development. This systematic review aimed to assess the accuracy of the third molar maturity index (I 3M), proposed by Cameriere et al. (2008), in discriminating whether an individual is under or over 18 years. Seven electronic databases were screened: PubMed, Scopus, ISI Web of Science, Cochrane Library, LILACS, SIGLE, and CAPES...
December 22, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29273007/efficacy-and-safety-of-weekly-nab-paclitaxel-plus-gemcitabine-in-chinese-patients-with-metastatic-adenocarcinoma-of-the-pancreas-a-phase-ii-study
#13
Ruihua Xu, Xianjun Yu, Jihui Hao, Liwei Wang, Hongming Pan, Guohong Han, Jianming Xu, Yanqiao Zhang, Shujun Yang, Jia Chen, Jieer Ying, Guanghai Dai, Mingyu Li, Damir Begic, Brian Lu, Lin Shen
BACKGROUND: This phase II bridging study assessed the safety and efficacy of nab-paclitaxel/gemcitabine (Metastatic Pancreatic Adenocarcinoma Clinical Trial [MPACT] regimen) in Chinese patients with metastatic pancreatic cancer (MPC). METHODS: This 3-part sequential study evaluated nab-paclitaxel 125 mg/m2 plus gemcitabine 1000 mg/m2 on days 1, 8, and 15 every 4 weeks. Part 1 evaluated safety. Part 2 evaluated efficacy using Simon's optimal 2-stage design: if >2 responses were observed in Stage 1 (n = 28), 54 additional patients would be enrolled in Stage 2...
December 22, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29262398/characteristic-microrna-expression-induced-by-%C3%AE-opioid-receptor-activation-in-the-rat-liver-under-prolonged-hypoxia
#14
Feng Zhi, Naiyuan Shao, Lian Xue, Yuan Xu, Xuezhi Kang, Yilin Yang, Ying Xia
BACKGROUND/AIMS: Hypoxic/ischemic injury to the liver is a frequently encountered clinical problem with limited therapeutic options. Since microRNAs (miRNAs) are involved in hypoxic/ ischemic events, and δ-opioid receptor (DOR) is protective against hypoxic/ischemic injury, we asked if pharmacological activation of DOR can alter hypoxic events by regulating miRNA expression in the liver. As the first step, the present work aimed at testing the effect of DOR activation on hepatic miRNA expression in hypoxia...
December 14, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29259977/potential-role-of-microrna-375-as-biomarker-in-human-cancers-detection-a-meta-analysis
#15
REVIEW
Jin Yan, Qiang She, Xiaoran Shen, Yifeng Zhang, Bingtuan Liu, Guoxin Zhang
The association between circulating microRNA-375 (miR-375) expression and cancers has been studied; however, the results are inconsistent. We searched PubMed, Embase, and Web of Science for studies concerning the diagnostic value of miR-375 for cancer. The bivariate meta-analysis model was employed to summarize sensitivity, specificity, and diagnostic odds ratio (DOR) for miR-375 in the diagnosis of cancer. Summary receiver operating characteristic (SROC) curve analysis and the area under the curve (AUC) were also used to check the overall test performance...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29249970/validation-of-a-case-finding-algorithm-for-identifying-patients-with-non-small-cell-lung-cancer-nsclc-in-administrative-claims-databases
#16
Ralph M Turner, Yen-Wen Chen, Ancilla W Fernandes
Objective: To assess the validity of a treatments- and tests-based Case-Finding Algorithm for identifying patients with non-small cell lung cancer (NSCLC) from claims databases. Data sources: Primary data from the HealthCore Integrated Research Environment (HIRE)-Oncology database and the HealthCore Integrated Research Database (HIRD) were collected between June 1, 2014, and October 31, 2015. Study design: A comparative statistical evaluation using receiver operating characteristic (ROC) curve analysis and other validity measures was used to validate the NSCLC Case-Finding Algorithm vs...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29249837/a-gender-bias-habit-breaking-intervention-led-to-increased-hiring-of-female-faculty-in-stemm-departments
#17
Patricia G Devine, Patrick S Forscher, William T L Cox, Anna Kaatz, Jennifer Sheridan, Molly Carnes
Addressing the underrepresentation of women in science is a top priority for many institutions, but the majority of efforts to increase representation of women are neither evidence-based nor rigorously assessed. One exception is the gender bias habit-breaking intervention (Carnes et al., 2015), which, in a cluster-randomized trial involving all but two departmental clusters (N = 92) in the 6 STEMM focused schools/colleges at the University of Wisconsin - Madison, led to increases in gender bias awareness and self-efficacy to promote gender equity in academic science departments...
November 2017: Journal of Experimental Social Psychology
https://www.readbyqxmd.com/read/29247963/ecog-high-gamma-modulation-versus-electrical-stimulation-for-presurgical-language-mapping
#18
Ravindra Arya, Paul S Horn, Nathan E Crone
OBJECTIVE: This meta-analysis compared diagnostic validity of electrocorticographic (ECoG) high-γ modulation (HGM) with electrical stimulation mapping (ESM) for presurgical language localization. METHODS: From a structured literature search, studies with electrode level data comparing ECoG HGM and ESM for language localization were included in the meta-analysis. Outcomes included global measures of diagnostic validity: area under the summary receiver operating characteristic (SROC) curve (AUC), and diagnostic odds ratio (DOR); as well as pooled estimates of sensitivity and specificity...
December 13, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29247674/developmental-exposure-to-low-level-ambient-ultrafine-particle-air-pollution-and-cognitive-dysfunction
#19
D A Cory-Slechta, J L Allen, K Conrad, E Marvin, M Sobolewski
Developmental exposures to ambient ultrafine particles (UFPs) can produce multiple neuropathological and neurochemical changes that might contribute to persistent alterations in cognitive-type functions. The objective of the current study was to test the hypothesis that developmental UFP exposure produced impairments in learning, memory and impulsive-like behaivors and to determine whether these were selective and thus independent of deficits in other behavioral domains such as motor activity or motivation...
December 13, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/29246009/evaluation-of-the-nmp22-bladderchek-test-for-detecting-bladder-cancer-a-systematic-review-and-meta-analysis
#20
Zijie Wang, Hongliang Que, Chuanjian Suo, Zhijian Han, Jun Tao, Zhengkai Huang, Xiaobin Ju, Ruoyun Tan, Min Gu
Background: We examined the usefulness of the nuclear matrix protein 22 (NMP22) BladderChek test for detecting bladder cancer. Materials and Methods: A literature search was performed using PubMed, Embase, the Cochrane Library, and Web of Science. The diagnostic accuracy of the NMP22 BladderChek test was evaluated via pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under curve (AUC)...
November 21, 2017: Oncotarget
keyword
keyword
97576
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"