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https://www.readbyqxmd.com/read/28808361/interleukin-6-an-early-predictive-marker-for-severity-of-acute-pancreatitis
#1
Shilpa A Rao, Aditya R Kunte
BACKGROUND AND AIMS: Interleukin (IL)-6, IL-8, IL-10, and C-reactive protein (CRP) have been evaluated for predicting outcomes of acute pancreatitis. However, there is considerable variation in their performance among different studies. We evaluate their accuracy in predicting progression to severe pancreatitis. MATERIALS AND METHODS: Serum IL-6, IL-8, IL-10, and CRP levels were measured within 24 h of admission in forty patients of clinically predicted severe acute pancreatitis (SAP)...
July 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28807672/pharmacological-characterization-of-novel-synthetic-opioids-nso-found-in-the-recreational-drug-marketplace
#2
REVIEW
Michael H Baumann, Susruta Majumdar, Valerie Le Rouzic, Amanda Hunkele, Rajendra Uprety, Xi Ping Huang, Jin Xu, Bryan L Roth, Ying-Xian Pan, Gavril W Pasternak
Novel synthetic opioids (NSO) are increasingly encountered in illicit heroin and counterfeit pain pills. Many NSO are resurrected from older biomedical literature or patent applications, so limited information is available about their biological effects. Here we examined the pharmacology of three structurally-distinct NSO found in the recreational drug market: N-(1-(2-phenylethyl)-4-piperidinyl)-N-phenylbutyramide (butyrylfentanyl), 3,4-dichloro-N-[(1R,2R)-2-(dimethylamino)cyclohexyl]-N-methylbenzamide (U-47700) and 1-cyclohexyl-4-(1,2-diphenylethyl)piperazine (MT-45)...
August 11, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28797030/one-step-nucleic-acid-amplification-assay-is-an-accurate-technique-for-sentinel-lymph-node-biopsy-of-breast-cancer-patients-a-meta-analysis
#3
Fang Shi, Qian Zhang, Zhenzhen Liang, Mengmeng Zhang, Xin Liu
BACKGROUND: To estimate the accuracy of one-step nucleic acid amplification (OSNA) assay as an intra-operative sentinel lymph node biopsy (SLNB) for sentinel lymph node (SLN) metastasis in breast cancer. METHODS: PubMed, Cochrane Library and Web of Science databases were searched by two independent reviewers to retrieve literature with per-patient analysis. The deadline was up until December 2016. A meta-analysis was performed using STATA, Meta-Disc, and Revman software...
August 10, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28796582/mortality-salience-reduces-tactile-attention-among-people-with-low-body-esteem
#4
Jonathan Beyrak-Lev, Zach Gerber, Tsachi Ein-Dor, Gilad Hirschberger
Death awareness leads to aversion from bodily processes such as breastfeeding and sex, especially among low body-esteem individuals. Using a Modality Bias Task we examined whether primes of death reduced attention to bodily sensations. We subliminally primed 72 undergraduates with either the word death or failed, and assessed their attention to tactile and visual stimuli as a function of their body esteem. Results indicated that death primes significantly reduced attention to tactile stimuli relative to visual stimuli in low body-esteem individuals...
August 10, 2017: Death Studies
https://www.readbyqxmd.com/read/28792699/microrna-150-as-a-potential-biomarker-in-diagnosis-of-cancer-a-meta-analysis
#5
Jin Yan, Xuan Li, Lei Peng, Xiaoran Shen, Yini Dang, Guoxin Zhang
BACKGROUND: Altered expression of microRNAs contributes to human carcinogenesis. Previous studies assessed the association of aberrant circulating microRNA (miR)-150 level with the risk in developing various human cancers, but the data were inconsistent. METHODS: This meta-analysis further assessed the potential diagnostic value of miR-150 in cancer. PubMed, Embase, and Web of Science for publications were searched using the keywords of miR-150 and human cancer...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28790406/the-diagnostic-accuracy-of-magnetic-resonance-imaging-for-anterior-cruciate-ligament-injury-in-comparison-to-arthroscopy-a-meta-analysis
#6
Kun Li, Jun Du, Li-Xin Huang, Li Ni, Tao Liu, Hui-Lin Yang
We performed this meta-analysis to examine the diagnostic accuracy of MRI for the diagnosis of anterior cruciate ligament (ACL) injury in comparison to arthroscopy. We also compared the diagnostic accuracy of MRI with magnetic field intensities (MFI) greater than or equal to 1.5T with those below 1.5T, in addition to different MRI sequences. Studies relevant to the diagnosis of ACL injury by MRI and arthroscopy were analyzed. Computer and manual retrieval were carried out on studies published between January 1, 2006 and May 31, 2016...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28781142/reprint-of-localization-of-cl-35-nuclei-in-biological-solids-using-rotational-echo-double-resonance-experiments
#7
D Iuga, P Rossi, J Herzfeld, R G Griffin
Chloride ions play important roles in many chemical and biological processes. This paper investigates the possibility of localizing (35)Cl nuclei using solid-state NMR. It demonstrates that distances shorter than 3.8Å, between (13)C atoms and (35)Cl atoms in 10% uniformly labeled (13)C L-tyrosine·HCl and natural abundance Glycine·HCl can be measured using rotational-echo (adiabatic passage) double-resonance (RE(AP)DOR). Furthermore the effect of quadrupolar interaction on the REDOR/REAPDOR experiment is quantified...
August 3, 2017: Solid State Nuclear Magnetic Resonance
https://www.readbyqxmd.com/read/28777487/towards-a-conditional-approach-to-anonymity-an-explorative-multi-center-longitudinal-study-among-anonymous-living-kidney-donors-and-recipients
#8
Mathilde C Pronk, Dorthe Slaats, Karlijn A M I van der Pant, Janneke Vervelde, Ine M M Dooper, Frank J M F Dor, Willem Weimar, Jacqueline van de Wetering, Willij C Zuidema, Emma K Massey
Anonymity between living donors and recipients is a topic of discussion among transplant professionals. This longitudinal study explored living kidney donors' and patients' perspectives on anonymity. Prior to surgery (T0) and 3 months afterwards (T1) participants in unspecified or specified indirect donation programs completed a questionnaire on their experiences with and attitudes towards anonymity as well as demographic and medical characteristics. Non-parametric tests were used to assess group differences and associations...
August 4, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28770957/can-procalcitonin-be-used-to-diagnose-gram-negative-bloodstream-infection-evidence-based-on-a-meta-analysis
#9
C He, B Wang, Y-F Wang, Y-C Shen
OBJECTIVE: Procalcitonin (PCT) is a useful biomarker for systemic bacterial infection, and many studies have described the correlation between high serum PCT level and Gram-negative bloodstream infection (BSI), whereas the diagnostic accuracy of PCT for this kind of episode has not been summarized. This study aimed to estimate the overall accuracy of serum PCT for diagnosing Gram-negative BSI through a meta-analysis. MATERIALS AND METHODS: We searched PubMed, EMBASE, Web of Science, and Scopus database for studies that met the inclusion criteria...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28756558/the-old-15%C3%A2-mm-renal-stone-size-limit-for-rirs-remains-a-clinically-significant-threshold-size
#10
Hanan Goldberg, Dor Golomb, Yariv Shtabholtz, Shlomi Tapiero, German Creiderman, Avi Shariv, Jack Baniel, David Lifhshitz
PURPOSE: To investigate the performance of retrograde intrarenal surgery (RIRS) for the 1-2 cm renal stone size range in comparison to smaller stones. MATERIALS AND METHODS: From a data base of 3000 ureteroscopies between 2004 and 2014, 635 consecutive patients underwent RIRS for renal stones. Patients were divided to three groups according to their renal stone size (<10, 10-15, 15-20 mm). Preoperative, operative, stone free rate (SFR) and follow-up data were analyzed and compared...
July 29, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28755442/vacuolar-processing-enzyme-vpe-activates-programmed-cell-death-in-the-apical-meristem-inducing-loss-of-apical-dominance
#11
Paula Teper-Bamnolker, Yossi Buskila, Eduard Belausov, Dalia Wolf, Adi Doron-Faigenboim, Shifra Ben-Dor, Renier A L Van der Hoorn, Amnon Lers, Dani Eshel
The potato (Solanum tuberosum L.) tuber is a swollen underground stem that can sprout in an apical dominance (AD) pattern. Bromoethane (BE) induces loss of AD and the accumulation of vegetative vacuolar processing enzyme (StVPE) in the tuber apical meristem (TAM). VPE activity, induced by BE, is followed by programmed cell death in the TAM. In this study, we found that the mature StVPE1 protein (mVPE) exhibits specific activity for caspase-1, but not caspase-3 substrates. Optimal activity of mVPE was achieved at acidic pH, consistent with localization of StVPE1 to the vacuole, at the edge of the TAM...
July 28, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28750978/a-myofascial-component-of-pain-in-knee-osteoarthritis
#12
REVIEW
Adi Dor, Leonid Kalichman
BACKGROUND: Osteoarthritis (OA) is the most common cause of musculoskeletal pain and disability. The knee is the most common site of OA. Numerous studies have shown an inconsistency between patients' reports of pain and their radiographic findings. This inconsistency may be partially explained by the fact that a portion of the pain originates from the myofascial trigger points (MTrPs) located in the surrounding muscles. AIM: To assess the role of myofascial pain in OA patients...
July 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/28749700/radiographic-diagnosis-of-root-fractures-a-systematic-review-meta-analyses-and-sources-of-heterogeneity
#13
Fernanda Cristina Sales Salineiro, Solange Kobayashi-Velasco, Mariana Minatel Braga, Marcelo Gusmão Paraiso Cavalcanti
OBJECTIVE: Many studies to evaluate the accuracy of root fracture diagnosis have been conducted. However, there is a scarcity of studies to assess the quality and the sources of heterogeneity in the literature. For this reason, the aim of this study was to conduct systematic reviews and meta-analyses to summarize the available evidence on detection of root fractures by CBCT and PR images and the interference of artifact by investigating possible sources of heterogeneity. METHODS: Studies reporting root fracture detection, from January 2010 to February 2016, were selected...
July 27, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28747531/remarkable-size-spectra-stability-in-a-marine-system-undergoing-massive-invasion
#14
Yehezkel Buba, Itai van Rijn, Shane A Blowes, Oren Sonin, Dor Edelist, John P DeLong, Jonathan Belmaker
The Mediterranean Sea is an invasion hotspot, with non-indigenous species suspected to be a major driver behind community changes. We used size spectra, a reliable index of food web structure, to examine how the influx of Red Sea fishes into the Mediterranean Sea has impacted the indigenous species community. This is the first attempt to use changes in the size spectra to reveal the effect of biological invasions. We used data from trawl catches along Israel's shoreline spanning 20 years to estimate changes in the community size spectra of both indigenous and non-indigenous species...
July 2017: Biology Letters
https://www.readbyqxmd.com/read/28747085/predictors-in-starting-and-stopping-internet-use-between-2002-and-2012-by-dutch-adults-65-years-and-older
#15
Jessica Berner, Marja Aartsen, Dorly Deeg
Research has indicated the need to consider the ageing process with technology adoption by older adults. This study examined psychological, health, social and demographic predictors with starting and stopping Internet use by older adults (2002-2012). Data were used from the Longitudinal Aging Study Amsterdam, and Cox regression analyses were done to test predictors over time with starting or stopping Internet use. The results indicated that older adults starting to use the Internet (11.6%) outnumbered those who stopped (3...
July 1, 2017: Health Informatics Journal
https://www.readbyqxmd.com/read/28746202/assessing-diagnostic-value-of-contrast-enhanced-ultrasound-and-contrast-enhanced-computed-tomography-in-detecting-small-hepatocellular-carcinoma-a-meta-analysis
#16
COMPARATIVE STUDY
Jiasheng Huang, Wei Chen, Shanwen Yao
BACKGROUND: This study aimed to compare the diagnostic values of contrast-enhanced ultrasound (CEUS) and contrast-enhanced computed tomography (CECT) in detecting small hepatocellular carcinoma (SHCC). METHODS: A series of related articles from 2001 to 2015 were searched in PubMed and Embase databases. Data from selected articles were pooled to analyze the sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and summary receiver operating characteristic (SROC) curve using Meta-DiSc software...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28745376/stereoselective-synthesis-of-conformationally-restricted-kor-agonists-based-on-the-2-5-diazabicyclo-2-2-2-octane-scaffold
#17
Christian Wittig, Dirk Schepmann, Michael Soeberdt, Constantin G Daniliuc, Bernhard Wünsch
It has been postulated that the KOR affinity depends on the dihedral angle of the ethylenediamine pharmacophore. Herein, 2,5-diazabicyclooctanes bearing a pyrrolidino moiety in the 7-position were envisaged to study KOR agonists with a conformationally rigid ethylenediamine pharmacophore and thus a defined N(pyrrolidine)-C7-C1-N2 dihedral angle. The first approach with an intramolecular addition at the chiral sulfinylimines 9 failed to give bicyclic products. The key step in the second approach was a Dieckmann analogous cyclization providing mixed methyl silyl ketals 11a-e as key intermediates...
August 9, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28742247/ventana-immunohistochemistry-assay-for-anaplastic-lymphoma-kinase-gene-rearrangement-detection-in-patients-with-non-small-cell-lung-cancer-a-meta-analysis
#18
Wang Zhiwei, Jiang Yuan, Yao Yihui, Hou Xin, Chen Jingtao, Shi Lei, Duan Yongjian
BACKGROUND: The aim of this study was to evaluate the diagnostic value of Ventana immunohistochemistry (IHC) assay for anaplastic lymphoma kinase (ALK) gene rearrangement screening in patients with non-small cell lung cancer (NSCLC). METHODS: Open published studies that reported the diagnostic performance of Ventana IHC assay for ALK gene rearrangement detection in NSCLC patients were extracted from PubMed, Embase, Google scholar, Wanfang, and China National Knowledge Infrastructure...
July 25, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28739183/can-crosstalk-between-dor-and-parp-reduce-oxidative-stress-mediated-neurodegeneration
#19
REVIEW
Rutika Raina, Dwaipayan Sen
The progressive loss of structure and function of neurons leads to neurodegenerative processes which become the causative reason for various neurodegenerative diseases such as Parkinson's disease (PD), Alzheimer's disease (AD) etc. These diseases are multifactorial in nature but they have been seen to possess similar causative agents to a certain extent. Oxidative Stress (OS) has been identified as a major stressor and a mediator in most of these diseases. OS not only leads to the generation of free radical species but if persistent, can possibly lead to lipid peroxidation, protein damage, DNA damage, and cell death...
July 21, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28738234/m1-homeopathic-complex-trigger-effective-responses-against-leishmania-l-amazonensis-in-vivo-and-in-vitro
#20
Katia Fialho Nascimento, Fabiana Rodrigues de Santana, Cleber Rafael Vieira da Costa, Vanessa Kaplum, Helito Volpato, Celso Vaturo Nakamura, Leoni Villano Bonamin, Dorly de Freitas Buchi
Leishmaniasis is a term referring to a range of clinical conditions caused by protozoan parasites of the genus Leishmania, Trypanosomatidae family, Kinetoplastida order that is transmitted by the bite of certain species of mosquitoes Phlebotominae subfamily. These parasites infect hosts wild and domestic mammals, considered as natural reservoirs and can also infect humans. Leishmania are obligate intramacrophage protozoa that have exclusively intracellular life style. This suggests that the amastigotes possess mechanisms to avoid killing by host cells...
July 21, 2017: Cytokine
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