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https://www.readbyqxmd.com/read/28212993/efficacy-according-to-blind-independent-central-review-post-hoc-analyses-from-the-phase-iii-randomized-multicenter-ipass-study-of-first-line-gefitinib-versus-carboplatin-paclitaxel-in-asian-patients-with-egfr-mutation-positive-advanced-nsclc
#1
Yi-Long Wu, Nagahiro Saijo, Sumitra Thongprasert, J C-H Yang, Baohui Han, Benjamin Margono, Busayamas Chewaskulyong, Patrapim Sunpaweravong, Yuichiro Ohe, Yukito Ichinose, Jin-Ji Yang, Tony S K Mok, Helen Young, Vincent Haddad, Yuri Rukazenkov, Masahiro Fukuoka
OBJECTIVE: The Phase III, randomized, open-label IPASS study (NCT00322452) of first-line epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI) gefitinib versus carboplatin/paclitaxel for Asian patients with advanced non-small-cell lung cancer (NSCLC) showed that investigator-assessed progression-free survival (PFS) and objective response rate (ORR) were significantly prolonged in patients with EGFR mutation-positive NSCLC who received gefitinib versus patients with EGFR mutation-negative NSCLC...
February 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28204957/insights-into-the-role-of-opioid-receptors-in-the-gi-tract-experimental-evidence-and-therapeutic-relevance
#2
James J Galligan, Catia Sternini
Opioid drugs are prescribed extensively for pain treatment but when used chronically they induce constipation that can progress to opioid-induced bowel dysfunction. Opioid drugs interact with three classes of opioid receptors: mu opioid receptors (MORs), delta opioid receptors (DOR), and kappa opioid receptors (KORs), but opioid drugs mostly target the MORs. Upon stimulation, opioid receptors couple to inhibitory Gi/Go proteins that activate or inhibit downstream effector proteins. MOR and DOR couple to inhibition of adenylate cyclase and voltage-gated Ca(2+) channels and to activation of K(+) channels resulting in reduced neuronal activity and neurotransmitter release...
February 16, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28198953/predictors-of-hope-among-women-with-breast-cancer-during-chemotherapy
#3
Alessandra Cristina Sartore Balsanelli, Sonia Aurora Alves Grossi
OBJECTIVE: Identifying the predictors of hope in patients with breast cancer during chemotherapy treatment. METHOD: A prospective longitudinal study. The sample was composed of 122 women who responded to the instruments of hope, anxiety and depression, coping, fatigue, religiosity and self-esteem in the first and last cycle of chemotherapy. These variables were used in adjusting the logistic regression model that characterized multivariate statistics, allowing identification of predictor variables...
November 2016: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28194733/surgical-management-for-achalasia-after-coronary-artery-bypass-graft-using-the-right-gastroepiploic-artery-a-case-report
#4
Ryo Muranushi, Tatsuya Miyazaki, Hideyuki Saito, Kengo Kuriyama, Tomonori Yoshida, Yuji Kumakura, Hiroaki Honjyo, Takehiko Yokobori, Makoto Sakai, Makoto Sohda, Hiroyuki Kuwano
BACKGROUND: The right gastroepiploic artery is commonly used in coronary artery bypass grafting. Appropriate strategies are required when performing upper abdominal surgeries after the right gastroepiploic artery has been used in coronary artery bypass grafting because compressing or injuring the graft may cause myocardial ischemia and fatal arrhythmias. To our knowledge, this is the first reported case of surgery for achalasia performed after coronary artery bypass grafting using the right gastroepiploic artery...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28192852/effective-disengagement-insecure-people-are-more-likely-to-disengage-from-an-ongoing-task-and-take-effective-action-when-facing-danger
#5
Tsachi Ein-Dor, Adi Perry-Paldi, Jenna Merrin, Yaniv Efrati, Gilad Hirschberger
OBJECTIVE: People believe that they can respond effectively to threats, but actually experience difficulties in disengaging from ongoing tasks and shifting their attention to life-threatening events. We contend that this tendency is especially true for secure people with respect to their worldview and perception of others and not to insecure individuals. METHOD: In Study 1 (N=290), we examined individuals' reactions to various threat scenarios. In Study 2 (N=65), we examined these reactions using a behavioral design high in ecological validity...
February 13, 2017: Journal of Personality
https://www.readbyqxmd.com/read/28188488/long-noncoding-rnas-as-novel-serum-biomarkers-for-the-diagnosis-of-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#6
C Zheng, H Hao, L Chen, J Shao
PURPOSE: Long noncoding RNAs (lncRNAs) are outstanding as novel cancer biomarkers with great prospects. Herein, we focused on summarizing the overall diagnostic evaluation of lncRNAs for hepatocellular carcinoma (HCC). METHODS: Relevant literature was collected from the online databases. The Quality Assessment for Studies of Diagnostic Accuracy checklist was used to assess the quality of included studies. The pooled sensitivity, specificity, and diagnostic odds ratio (DOR) were plotted using random-effects models...
February 10, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28187333/localization-of-cl-35-nuclei-in-biological-solids-using-rotational-echo-double-resonance-experiments
#7
D Iuga, P Rossi, J Herzfeld, R G Griffin
Chloride ions play important roles in many chemical and biological processes. This paper investigates the possibility of localizing (35)Cl nuclei using solid-state NMR. It demonstrates that distances shorter than 3.8Å, between (13)C atoms and (35)Cl atoms in 10% uniformly labeled (13)C L-tyrosine·HCl and natural abundance Glycine·HCl can be measured using rotational-echo (adiabatic passage) double-resonance (RE(AP)DOR). Furthermore the effect of quadrupolar interaction on the REDOR/REAPDOR experiment is quantified...
January 30, 2017: Solid State Nuclear Magnetic Resonance
https://www.readbyqxmd.com/read/28181834/functioning-without-cartilage-older-people-with-radiographic-knee-osteoarthritis-who-self-report-no-functional-limitations-do-score-lower-on-a-performance-battery
#8
Daniël M van Leeuwen, Fabian van de Bunt, Cornelis J de Ruiter, Natasja M van Schoor, Dorly J H Deeg, Kaj S Emanuel
The majority of the older population shows signs of radiographic knee osteoarthritis. However, many remain without functional complaints for a long period. This study aims to find early functional changes associated with stages of radiographic knee osteoarthritis. A group of older people without self-reported complaints was divided in 2 groups, knee osteoarthritis (K&L=2-4, N=29) and control (K&L=0-1, N=31). Muscle function was assessed with voluntary and electrically stimulated isometric knee contractions, including a fatigue test...
February 9, 2017: Journal of Aging and Physical Activity
https://www.readbyqxmd.com/read/28181050/outcome-of-gestational-surrogacy-according-to-ivf-protocol
#9
Ronit Machtinger, Nir-Ram Duvdevani, Oshrit Lebovitz, Jehoshua Dor, Ariel Hourvitz, Raoul Orvieto
PURPOSE: Surrogacy remains the only option for having a biologic child for a unique population of women with severe medical conditions. However, no study has looked at surrogacy outcome as a result of the type of ovarian stimulation of the intended mother [controlled ovarian stimulation (COH), modified natural cycle (MNC), and in vitro maturation (IVM)] for oocyte retrieval. METHODS: This is a retrospective study, including all intended mothers and gestational carriers in a tertiary, university affiliated, medical center, from 1998 to 2016...
February 8, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28180042/brainstem-auditory-evoked-potentials-diagnostic-accuracy-for-hearing-loss-systematic-review-and-meta-analysis
#10
Parthasarathy D Thirumala, Gregory Carnovale, Yoon Loke, Miguel E Habeych, Donald J Crammond, Jeffrey R Balzer, Raymond F Sekula
Background Microvascular decompression (MVD) utilizes brainstem auditory evoked potential (BAEP) intraoperative monitoring to reduce the risk of iatrogenic hearing loss. Studies report varying efficacy and hearing loss rates during MVD with intraoperative monitoring. Objectives This study aims to perform a comprehensive review and study of diagnostic accuracy of BAEPs during MVD to predict hearing loss in studies published from January 1984 to December 2013. Methods The PubMed/MEDLINE and World Science databases were searched...
February 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28178436/femoral-versus-multiple-nerve-blocks-for-analgesia-after-total-knee-arthroplasty
#11
Anatoli Stav, Leonid Reytman, Roger Sevi, Michael Yohay Stav, Devorah Powell, Yanai Dor, Mickey Dudkiewicz, Fuaz Bayadse, Ahud Sternberg, Michael Soudry
BACKGROUND: The PROSPECT (Procedure-Specific Postoperative Pain Management) Group recommended a single injection femoral nerve block in 2008 as a guideline for analgesia after total knee arthroplasty. Other authors have recommended the addition of sciatic and obturator nerve blocks. The lateral femoral cutaneous nerve is also involved in pain syndrome following total knee arthroplasty. We hypothesized that preoperative blocking of all four nerves would offer superior analgesia to femoral nerve block alone...
January 30, 2017: Rambam Maimonides Medical Journal
https://www.readbyqxmd.com/read/28173995/gnrh-antagonist-and-letrozole-co-treatment-in-diminished-ovarian-reserve-patients-a-proof-of-concept-study
#12
Safak Olgan, Peter Humaidan
The current study aimed to investigate the effects of luteal gonadotropin-releasing hormone (GnRH) antagonist pretreatment on the outcomes of diminished ovarian reserve (DOR) patients who were treated using a FSH/letrozole/GnRH antagonist (FLA) protocol. Thus, patients who had luteal GnRH antagonist pretreatment (AFLA) prior to stimulation were compared to patients who had the FLA protocol, only. An electronic database was used to identify patients and stimulation characteristics. Women who had a total antral follicle count (AFC) of <7 were included in the analysis...
February 4, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/28172805/p345-inconsistency-between-electronic-data-of-patient-s-adherence-and-self-reported-adherence-score
#13
E Broide, A Ein Dor, N Ruhimovich, A B Shitrit, F Benjaminov, S Matalon, H Shirin, F M Konikoff, T Naftali
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172522/p561-can-we-predict-adherence-to-treatment-in-ibd-patients
#14
T Naftali, A Ein Dor, N Ruhimovich, A B Shitrit, F Sklerovsky Benjaminov, S Matalon, H Shirin, F M Konikoff, E Broide
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28164507/psad-test-in-the-diagnosis-of-prostate-cancer-a-meta-analysis
#15
Zhi-Jun Feng, Chong Xue, Jia-Ming Wen, Yi Li, Ming Wang, Nan Zhang
BACKGROUND: The aim of this study is to evaluate the diagnostic value of prostate-specific antigen density (PSAD) test in detecting prostate cancer. METHODS: We searched public databases including PubMed, Medline, Springer, Elsevier Science Direct, Cochrane Library, and Google scholar before June 2015. In this meta-analysis, specificity, positive LR, negative LR, and dOR of PSAD test in patients with prostate cancer were analyzed from published studies. We applied Meta-DiSc 1...
January 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28160324/molecular-diagnosis-of-%C3%AE-thalassemia-in-a-multi-ethnic-population
#16
Oded Gilad, Orna Steinberg Shemer, Michal Nevo, Orly Dgany, Tanya Krasnov, Sharon Noy-Lotan, Ron Rabinowicz, Nofar Amitai, Shifra Ben-Dor, Isaac Yaniv, Joanne Yacobovich, Hannah Tamary
OBJECTIVE: α-Thalassemia, one of the most common genetic diseases, is caused by deletions or point mutations affecting one to four α-globin genes. Molecular diagnosis is important to prevent the most severe forms of the disease. However, the diagnosis of α-thalassemia is complex due to a high variability of the genetic defects involved, with over 250 described mutations. We summarize herein the findings of genetic analyses of DNA samples referred to our laboratory for the molecular diagnosis of α-thalassemia, along with a detailed clinical description...
February 3, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28151984/livestock-associated-staphylococcus-aureus-on-polish-pig-farms
#17
Aneta Mroczkowska, Jacek Żmudzki, Natalia Marszałek, Monika Orczykowska-Kotyna, Iga Komorowska, Agnieszka Nowak, Anna Grzesiak, Ewelina Czyżewska-Dors, Arkadiusz Dors, Zygmunt Pejsak, Waleria Hryniewicz, Tomasz Wyszomirski, Joanna Empel
BACKGROUND: Livestock-associated Staphylococcus aureus (LA-SA) draws increasing attention due to its particular ability to colonize farm animals and be transmitted to people, which in turn leads to its spread in the environment. The aim of the study was to determine the dissemination of LA-SA on pig farms selected throughout Poland, characterize the population structure of identified S. aureus, and assess the prevalence of LA-SA carriage amongst farmers and veterinarians being in contact with pigs...
2017: PloS One
https://www.readbyqxmd.com/read/28149552/micrornas-are-novel-non-invasive-diagnostic-biomarkers-for-pulmonary-embolism-a-meta-analysis
#18
Han-Yu Deng, Gang Li, Jun Luo, Zhi-Qiang Wang, Xiao-Yan Yang, Yi-Dan Lin, Lun-Xu Liu
BACKGROUNDS: The diagnosis of pulmonary embolism (PE) still remains difficult in clinical practice. MicroRNAs (miRNAs) have been widely investigated as biomarkers for various diseases. However, the diagnostic biomarker value of miRNAs in the diagnosis of PE is unclear. Therefore, we conducted this meta-analysis to establish the diagnostic power of miRNAs for PE diagnosis. METHODS: A systematic literature search in PubMed and Embase was conducted to identify relevant studies dated up to July 22, 2016...
December 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28142201/lymph-node-and-circulating-t-cell-characteristics-are-strongly-correlated-in-end-stage-renal-disease-patients-but-highly-differentiated-t-cells-reside-within-the-circulation
#19
Burç Dedeoglu, Annelies E de Weerd, Ling Huang, Anton W Langerak, Frank J Dor, Mariska Klepper, Wenda Verschoor, Derek Reijerkerk, Carla C Baan, Nicolle H R Litjens, Michiel G H Betjes
BACKGROUND: Ageing is associated with changes in the peripheral T-cell immune system, which can be significantly influenced by latent cytomegalovirus (CMV) infection. To what extent changes in circulating T-cell populations correlate with T-cell composition of the lymph node (LN) is unclear, but crucial for a comprehensive understanding of the T-cell system. METHODS: T cells from peripheral blood (PB) and LN of end-stage renal disease patients were analyzed for frequency of recent thymic emigrants using CD31 expression and T-cell receptor excision circle content, relative telomere length and expression of differentiation markers...
January 31, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28139906/heteromer-induction-an-approach-to-unique-pharmacology
#20
Philip S Portoghese, Eyup Akgün, Mary M Lunzer
It is proposed that two types of opioid receptor heteromers exist: a) those that are constitutive and b) those that are induced by bivalent ligands. Mu opioid agonists interact with constitutive MOR-DOR heteromer to mediate tolerance and dependence. Bivalent ligand, MDAN21, is devoid of these adverse effects by virtue of its DOR antagonist pharmacophore. We propose that bivalent ligands MMG22 and MCC22 induce colocalized receptors to form heteromers (MOR-mGluR5 and MOR-CCR5, respectively) that do not occur naturally, thereby promoting unique pharmacology...
January 31, 2017: ACS Chemical Neuroscience
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