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https://www.readbyqxmd.com/read/28933574/is-there-a-role-for-kisspeptin-in-pathogenesis-of-polycystic-ovary-syndrome
#1
Umit Gorkem, Cihan Togrul, Emine Arslan, Ayla Sargin Oruc, Nuriye Buyukkayaci Duman
AIM: To investigate association of kisspeptin levels in infertile women with different ovarian reserve patterns. MATERIALS AND METHODS: In this prospective cross-sectional study, 157 participants were recruited. The women were divided into three groups: (i) adequate ovarian reserve (AOR) (n = 57), (ii) high ovarian reserve (PCOS) (n = 60), (iii) diminished ovarian reserve (DOR) (n = 40). Weight, height, waist circumference (WC), hip circumference (HC), body mass index (BMI), waist/hip ratio (WHR) were measured...
September 21, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28928922/liver-transplantation-as-definitive-treatment-of-an-unresectable-mesenchymal-hamartoma-in-a-child-with-beckwith-wiedemann-syndrome
#2
Evelyn T Pan, Dor Yoeli, Michael L Kueht, N Thao N Galvan, Ronald T Cotton, Christine A O'Mahony, Abbas Rana, John A Goss
Mesenchymal liver hamartomas are benign tumors that can cause life-threatening abdominal distension and carry a risk for malignant transformation. In this case report, we describe a 13-month-old male with Beckwith-Wiedemann Syndrome (BWS) who presented with multiple mesenchymal liver hamartomas causing severe intra-abdominal mass effect. Imaging revealed six large multi-locular cystic lesions, ranging from 3.8 to 8.9 cm in diameter. The large size and spread of the tumors necessitated liver transplantation for complete removal...
August 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28924729/dor-vs-toupet-fundoplication-after-laparoscopic-heller-myotomy-long-term-randomized-controlled-trial-evaluated-by-high-resolution-manometry
#3
Gonzalo Torres-Villalobos, Enrique Coss-Adame, Janette Furuzawa-Carballeda, Fernanda Romero-Hernández, Blanca Blancas-Breña, Samuel Torres-Landa, Axel Palacios-Ramírez, Edgar Alejandro-Medrano, Axel Hernández-Ávila, Athenea Flores-Najera, Lourdes Margarita Ávila Escobedo, Cecilia Ramírez Angulo, Angélica Rodríguez-Garcés, Miguel Ángel Valdovinos
BACKGROUND: Laparoscopic Heller myotomy (LHM) with partial fundoplication is an effective treatment for achalasia. However, the type of fundoplication is still a subject of debate. AIM: The aim of the study is to identify which partial fundoplication leads to better control of acid exposure, manometric parameters, and symptoms scores. METHODS: A randomized controlled trial was performed to compare Dor vs Toupet fundoplication after LHM. The preoperative diagnosis was made by high-resolution manometry (HRM), upper endoscopy, and barium esophagogram...
September 18, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28918837/diagnostic-value-of-noninvasive-computed-tomography-perfusion-imaging-and-coronary-computed-tomography-angiography-for-assessing-hemodynamically-significant-native-coronary-artery-lesions
#4
REVIEW
Pooja Sethi, Hemang B Panchal, Sreenivas P Veeranki, Zia Ur Rahman, Hadii Mamudu, Timir K Paul
BACKGROUND: The objective of this study is to determine the diagnostic performance of computed tomography perfusion (CTP) with and without computed tomography angiography (CTA) in assessment of hemodynamically significant coronary artery lesions in comparison to invasive fractional flow reserve (FFR). MATERIALS AND METHODS: PubMed and Cochrane Center Register of Controlled Trials from January 2010 searched through December 2014. Nine original studies were selected evaluating the diagnostic performance of CTP with and without CTA to invasive coronary angiography in evaluation of hemodynamic significance of coronary lesions (n = 951)...
September 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28918716/the-existential-underpinnings-of-intergroup-helping-when-normative-and-defensive-motivations-collide
#5
Gilad Hirschberger, Jenna Hayes, Adi Shtrul, Tsachi Ein-Dor
Five studies examined defensive intergroup helping-when responsibility for an out-group victim's injury decreases helping, whereas lack of responsibility increases helping when death is salient. In Study 1 ( N = 350), implicit death primes increased petition signings to allow a Palestinian child to receive medical treatment in Israel, when the child was a victim of Palestinian fire. When the child was a victim of Israeli fire, however, death primes decreased petition signings. Study 2 ( N = 200) partially replicated these effects on commitment to donate blood to an injured Palestinian child...
October 2017: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/28912249/preoperative-staging-of-cholangiocarcinoma-and-biliary-carcinoma-using-18f-fluorodeoxyglucose-positron-emission-tomography-a-meta-analysis
#6
Jing-Hong Hu, Jui-Hsiang Tang, Cheng-Hui Lin, Yin-Yi Chu, Nai-Jen Liu
This meta-analysis was performed to determine the diagnostic accuracy of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) in assessing primary cholangiocarcinoma (CCA) and CCA with lymph node and distant metastasis. A literature search for studies reporting the use of 18F-FDG-PET for preoperative work-up/staging in patients with CCA was performed. Diagnostic OR (DOR) was used as an index of diagnostic performance of FDG-PET/CT in predicting primary CCA, lymph node metastases, and distant metastases...
September 14, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28912123/type-vi-secretion-system-mix-effectors-carry-both-antibacterial-and-anti-eukaryotic-activities
#7
Ann Ray, Nika Schwartz, Marcela de Souza Santos, Junmei Zhang, Kim Orth, Dor Salomon
Most type VI secretion systems (T6SSs) described to date are protein delivery apparatuses that mediate bactericidal activities. Several T6SSs were also reported to mediate virulence activities, although only few anti-eukaryotic effectors have been described. Here, we identify three T6SSs in the marine bacterium Vibrio proteolyticus and show that T6SS1 mediates bactericidal activities under warm marine-like conditions. Using comparative proteomics, we find nine potential T6SS1 effectors, five of which belong to the polymorphic MIX-effector class...
September 14, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28905803/diagnosis-and-treatment-of-gastroesophageal-reflux-disease-complicated-by-barrett-s-esophagus
#8
Andriy Stasyshyn
The aim of the study was to evaluate the effectiveness of a diagnostic and therapeutic algorithm for gastroesophageal reflux disease complicated by Barrett's esophagus in 46 patients. MATERIALS AND METHODS: A diagnostic and therapeutic algorithm for complicated GERD was developed. To describe the changes in the esophagus with reflux esophagitis, the Los Angeles classification was used. Intestinal metaplasia of the epithelium in the lower third of the esophagus was assessed using videoendoscopy, chromoscopy, and biopsy...
August 31, 2017: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/28902934/assessment-and-management-of-pain-in-newborns-hospitalized-in-a-neonatal-intensive-care-unit-a-cross-sectional-study
#9
Natália Pinheiro Braga Sposito, Lisabelle Mariano Rossato, Mariana Bueno, Amélia Fumiko Kimura, Taine Costa, Danila Maria Batista Guedes
Objective: to determine the frequency of pain, to verify the measures adopted for pain relief during the first seven days of hospitalization in the Neonatal Intensive Care Unit and to identify the type and frequency of invasive procedures to which newborns are submitted. Method: cross-sectional retrospective study. Out of the 188 hospitalizations occurred during the 12-month period, 171 were included in the study. The data were collected from the charts and the presence of pain was analyzed based on the Neonatal Infant Pain Scale and on nursing notes suggestions of pain...
September 12, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28887618/diagnostic-value-of-3d-time-of-flight-magnetic-resonance-angiography-for-detecting-intracranial-aneurysm-a-meta-analysis
#10
REVIEW
Liu HaiFeng, Xu YongSheng, Xun YangQin, Dou Yu, Wang ShuaiWen, Lu XingRu, Lei JunQiang
PURPOSE: This meta-analysis is to comprehensively evaluate the diagnostic performance of three-dimensional time-of-flight magnetic resonance angiography (3D-TOF-MRA) for detecting intracranial aneurysm (IA). METHODS: PubMed, Embase, Web of Science, and the Cochrane library were systematically searched for retrieving eligible studies. Study inclusion, data extraction, and risk of bias assessment were performed by two researchers independently. Pooled sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the curve (AUC) were calculated to assess the diagnostic value...
September 8, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28887209/thyroid-associated-orbitopathy-and-tears-a-proteomics-study
#11
Edina Kishazi, Marianne Dor, Simone Eperon, Aurélie Oberic, Mehrad Hamedani, Natacha Turck
To date, Thyroid-Associated Orbitopathy (TAO), an autoimmune inflammatory disease affecting the eye, remains poorly characterised and its diagnosis challenging. The aim of this study was to investigate the tears of the TAO patients in order to identify potential biomarkers. Two independent quantitative Tandem Mass Tag™ 6-plex experiments were done. After in-solution digestion and isoelectric fractionation, the 12 fractions were analysed with a LTQ Orbitrap Velos coupled to a liquid chromatography. Raw files were searched against Swiss-Prot-AC database using Proteome Discoverer software, with a false discovery rate of 1% at peptide and protein levels...
September 5, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28885658/circulating-tumor-dna-is-effective-for-detection-of-kras-mutation-in-colorectal-cancer-a-meta-analysis
#12
Min Tang, Zhenghua Deng, Baolin Li, Ying Peng, Min Song, Jinbo Liu
BACKGROUND: Circulating tumor DNA (ctDNA) offers a novel and minimally invasive approach to the detection of the KRAS oncogene mutation in colorectal cancer. This study was conducted to compare the prognostic value of ctDNA with that of the current gold standard tumor tissue analysis. METHODS: A systematic literature review was conducted to identify relevant articles published from inception to December 27, 2016; the PubMed, Web of Science, Embase, Wanfang and China National Knowledge Infrastructure databases were searched...
September 2, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28885493/systematic-review-and-meta-analysis-of-posttransplant-hepatic-artery-and-biliary-complications-in-patients-treated-with-transarterial-chemoembolization-before-liver-transplantation
#13
Dimitri Sneiders, Thymen Houwen, Liset H M Pengel, Wojciech G Polak, Frank J M F Dor, Hermien Hartog
BACKGROUND: Hepatic artery complications are feared complications after liver transplantation and may compromise the biliary tract, graft and patient survival. The objective of this systematic review and meta-analysis was to compare risk of hepatic artery and biliary complications after liver transplantation in patients who underwent neoadjuvant transarterial chemoembolization (TACE) vs. no TACE. METHODS: Comprehensive searches were performed in Embase, MEDLINE OvidSP, Web of Science, Google Scholar and Cochrane databases to identify studies concerning hepatocellular cancer patients undergoing preliver transplantation TACE...
September 6, 2017: Transplantation
https://www.readbyqxmd.com/read/28882436/antitumor-activity-and-safety-of-the-parp-inhibitor-rucaparib-in-patients-with-high-grade-ovarian-carcinoma-and-a-germline-or-somatic-brca1-or-brca2-mutation-integrated-analysis-of-data-from-study-10-and-ariel2
#14
Amit M Oza, Anna V Tinker, Ana Oaknin, Ronnie Shapira-Frommer, Iain A McNeish, Elizabeth M Swisher, Isabelle Ray-Coquard, Katherine Bell-McGuinn, Robert L Coleman, David M O'Malley, Alexandra Leary, Lee-May Chen, Diane Provencher, Ling Ma, James D Brenton, Gottfried E Konecny, Cesar M Castro, Heidi Giordano, Lara Maloney, Sandra Goble, Kevin K Lin, James Sun, Mitch Raponi, Lindsey Rolfe, Rebecca S Kristeleit
OBJECTIVE: An integrated analysis was undertaken to characterize the antitumor activity and safety profile of the oral poly(ADP-ribose) polymerase inhibitor rucaparib in patients with relapsed high-grade ovarian carcinoma (HGOC). METHODS: Eligible patients from Study 10 (NCT01482715) and ARIEL2 (NCT01891344) who received a starting dose of oral rucaparib 600mg twice daily (BID) with or without food were included in these analyses. The integrated efficacy population included patients with HGOC and a deleterious germline or somatic BRCA1 or BRCA2 (BRCA1/2) mutation who received at least two prior chemotherapies and were sensitive, resistant, or refractory to platinum-based chemotherapy...
September 4, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28880481/%C3%AE-cells-are-not-uniform-after-all-novel-insights-into-molecular-heterogeneity-of-insulin-secreting-cells
#15
REVIEW
Dana Avrahami, Yue J Wang, Agnes Klochendler, Yuval Dor, Benjamin Glaser, Klaus H Kaestner
While the β-cells of the endocrine pancreas are defined as cells with high levels of insulin production and tight stimulus-secretion coupling, the existence of functional heterogeneity among them has been known for decades. Recent advances in molecular technologies, in particular single-cell profiling on both the protein and messenger RNA level, have uncovered that β-cells exist in several antigenically and molecularly definable states. Using antibodies to cell surface markers or multidimensional clustering of β-cells using more than 20 protein markers by mass cytometry, 4 distinct groups of β-cells could be differentiated...
September 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28875483/comparison-of-diagnostic-accuracy-in-sepsis-between-presepsin-procalcitonin-and-c-reactive-protein-a-systematic-review-and-meta-analysis
#16
Chin-Chieh Wu, Hao-Min Lan, Shih-Tsung Han, Chung-Hsien Chaou, Chun-Fu Yeh, Su-Hsun Liu, Chih-Huang Li, Gerald N Blaney, Zhen-Ying Liu, Kuan-Fu Chen
BACKGROUND: The soluble cluster of differentiation 14 (or presepsin) is a free fragment of glycoprotein expressed on monocytes and macrophages. Although many studies have been conducted recently, the diagnostic performance of presepsin for sepsis remains debated. We performed a systematic review and meta-analysis of the available literature to assess the accuracy of presepsin for the diagnosis of sepsis in adult patients and compared the performance between presepsin, C-reactive protein (CRP), and procalcitonin (PCT)...
September 6, 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28875208/a-one-pot-multicomponent-approach-to-a-new-series-of-morphine-derivatives-and-their-biological-evaluation
#17
Jiaan Shao, Richard A Houghten, Colette T Dooley, Margret Cazares, Jay P McLaughlin, Shainnel O Eans, Michelle L Ganno, Michelle R Hoot, Marc A Giulianotti, Yongping Yu
A novel and facile domino reaction has been developed to synthesize a variety of new derivatives from hydromorphone, amines and paraformaldehyde in good yields in a catalyst-free fashion with high atom efficiency. The products show a mixed MOR/DOR biological characteristic which makes them valuable for further study as opioid analgesics.
September 6, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28864053/diaphragm-and-lung-ultrasound-to-predict-weaning-outcome-systematic-review-and-meta-analysis
#18
Ana M Llamas-Álvarez, Eva M Tenza-Lozano, Jaime Latour-Pérez
BACKGROUND: Deciding the optimal timing for extubation in mechanically ventilated patients can be challenging, and traditional weaning predictor tools are not very accurate. The aim of this systematic review and meta-analysis is to assess the accuracy of lung and diaphragm ultrasound for predicting weaning outcomes in critically ill adults. METHODS: We searched MEDLINE, the Cochrane Library, Web of Science, Scopus, LILACS, Teseo, Tesis Doctorales en Red, and OpenGrey, and we reviewed the bibliographies of relevant studies...
August 29, 2017: Chest
https://www.readbyqxmd.com/read/28857857/isoflurane-preconditioning-alleviated-murine-liver-ischemia-and-reperfusion-injury-by-restoring-ampk-mtor-mediated-autophagy
#19
Zhuqing Rao, Xiongxiong Pan, Hui Zhang, Jie Sun, Jingjin Li, Ting Lu, Mei Gao, Siying Liu, Dan Yu, Zhengnian Ding
BACKGROUND: Isoflurane has a pharmacological preconditioning effect against ischemia injury in the heart, kidney, and brain, but whether and how isoflurane preconditioning protects livers against ischemia and reperfusion (IR) injury is unclear. METHODS: Mice were randomly divided into an isoflurane preconditioning (ISO) group and control group, receiving 1.5% isoflurane or carrier gas for 40 minutes, respectively (n = 8/group). A partial warm liver IR model was used, and liver injury was evaluated...
October 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28857441/diagnostic-utility-of-hla-b-5801-screening-in-severe-allopurinol-hypersensitivity-syndrome-an-updated-systematic-review-and-meta-analysis
#20
Kuang-Hui Yu, Cheng-Yen Yu, Yao-Fan Fang
BACKGROUND: Despite many studies suggesting an association between human leukocyte antigen (HLA)-B*5801 and allopurinol-induced toxic epidermal necrolysis (TEN) and Stevens-Johnsons syndrome (SJS), the evidence of association in different populations and the degree of association remain uncertain. METHODS: The primary analysis was based on population-control studies. Data were pooled by means of a random-effects model, and sensitivity, specificity, positive likelihood ratios (LR+), negative likelihood ratios (LR-), diagnostic odds ratios (DOR), and areas under summary receiver operating characteristic (SROC) curves (AUC) were calculated...
August 31, 2017: International Journal of Rheumatic Diseases
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