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https://www.readbyqxmd.com/read/28093287/diagnostic-accuracy-of-imaging-devices-in-glaucoma-a-meta-analysis
#1
REVIEW
Monica Fallon, Oliver Valero, Marta Pazos, Alfonso Antón
Imaging devices such as the Heidelberg Retinal Tomograph (HRT3), scanning laser polarimetry (GDx), and optical coherence tomography (OCT), play an important role in glaucoma diagnosis. A systematic search for evidence-based data was performed for prospective studies evaluating the diagnostic accuracy of HRT3, GDx and OCT. The diagnostic odds ratio (DOR) was calculated. To compare the accuracy among instruments and parameters, a meta-analysis considering the hierarchical summary receiver operating characteristic (H-SROC) model was performed...
January 13, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28092793/high-dilutions-of-antimony-modulate-cytokines-production-and-macrophage-leishmania-l-amazonensis-interaction-in-vitro
#2
Fabiana Rodrigues de Santana, Luciane C Dalboni, Kátia F Nascimento, Fabiana Toshie Konno, Anuska M Alvares-Saraiva, Michelle S F Correia, Maristela Dutra Correa Bomfim, Renato C V Casarin, Elizabeth C Perez, Maria Anete Lallo, Giovani B Peres, Márcia Dalastra Laurenti, Nilson R Benites, Dorly F Buchi, Leoni Villano Bonamin
BACKGROUND: In previous results mice treated with high dilutions of antimony presented reduction of monocyte migration to the site of infection with increase in B lymphocytes population in the local lymph node. AIMS: To know the mechanisms involved, a series of in vitro studies was done, using co-cultures of macrophages (RAW 264.7) and Leishmania (L.) amazonensis treated with different dilutions of antimony (Antimonium crudum or AC), in different times. METHODOLOGY: Spreading, phagocytosis, the oxidative activity of macrophages, the viability of free promastigotes and the cytokines/chemokines concentration in the supernatant were evaluated...
January 13, 2017: Cytokine
https://www.readbyqxmd.com/read/28076600/use-of-cuff-tear-arthroplasty-head-prosthesis-for-rotator-cuff-arthropathy-treatment-in-elderly-patients-with-comorbidities
#3
Cassiano Diniz Carvalho, Carlos Vicente Andreoli, Alberto de Castro Pochini, Benno Ejnisman
Objective: To evaluate the clinical and functional behavior of patients undergoing cuff tear arthroplasty at different stages of the disease. Methods: Cuff tear arthroplasty hemiarthroplasties were performed in 34 patients with rotator cuff arthropathy and associated comorbidities, classified according to Seebauer. The mean age was 76.3 years, and the sample comprised 23 females (67.6%) and 11 males (32.4%). The mean follow-up period was 21.7 months, and evaluations were performed using the Visual Analog Scale for pain and the Constant scale...
October 2016: Einstein
https://www.readbyqxmd.com/read/28073840/fda-approval-summary-sonidegib-for-locally-advanced-basal-cell-carcinoma
#4
Denise Casey, Suzanne Demko, Stacy Shord, Hong Zhao, Huanyu Chen, Kun He, Alexander Putman, Whitney S Helms, Patricia Keegan, Richard Pazdur
On July 24, 2015, the U. S. Food and Drug Administration (FDA) approved sonidegib (ODOMZO®, Novartis) for treatment of patients with locally advanced basal cell carcinoma (laBCC) not amenable to curative surgery or radiation therapy. The approval was based on data from one randomized, double-blind, non-comparative trial of two doses of sonidegib administered to 230 hedgehog inhibitor-naïve patients with metastatic basal cell carcinoma (mBCC, n=36) or laBCC (n=194). Patients were randomized 2:1 to receive sonidegib 800 mg (n=151) or 200 mg (n=79) daily...
January 10, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28067955/cancer-preventive-services-socioeconomic-status-and-the-affordable-care-act
#5
Gregory S Cooper, Tzuyung Doug Kou, Avi Dor, Siran M Koroukian, Mark D Schluchter
BACKGROUND: Out-of-pocket expenditures are thought to be an important barrier to the receipt of cancer preventive services, especially for those of a lower socioeconomic status (SES). The Affordable Care Act (ACA) eliminated out-of-pocket expenditures for recommended services, including mammography and colonoscopy. The objective of this study was to determine changes in the uptake of mammography and colonoscopy among fee-for-service Medicare beneficiaries before and after ACA implementation...
January 9, 2017: Cancer
https://www.readbyqxmd.com/read/28066928/predictive-factors-and-outcomes-for-ibrutinib-therapy-in-relapsed-refractory-mantle-cell-lymphoma-a-real-world-study
#6
Narendranath Epperla, Mehdi Hamadani, Amanda F Cashen, Kwang W Ahn, Eunhye Oak, Abraham S Kanate, Oscar Calzada, Jonathon B Cohen, Luke Farmer, Nilanjan Ghosh, Michael Tallarico, Chadi Nabhan, Luciano J Costa, Vaishalee P Kenkre, Parameswaran N Hari, Timothy S Fenske
Ibrutinib has demonstrated significant activity in relapsed/refractory mantle cell lymphoma (MCL) in clinical trials. However, the impact of hematopoietic cell transplantation on the outcomes of ibrutinib and the predictive factors for ibrutinib response has not been well studied. Hence, we conducted a multicenter retrospective study of MCL patients who received ibrutinib to (1) determine the overall response rate (ORR), duration of response (DOR), progression-free survival (PFS), and overall survival (OS) of ibrutinib in routine clinical practice, (2) examine characteristics predictive of response to ibrutinib therapy, and (3) describe the outcomes of patients failing ibrutinib...
January 8, 2017: Hematological Oncology
https://www.readbyqxmd.com/read/28066600/white-light-autofluorescence-and-narrow-band-imaging-bronchoscopy-for-diagnosing-airway-pre-cancerous-and-early-cancer-lesions-a-systematic-review-and-meta-analysis
#7
Jianrong Zhang, Jieyu Wu, Yujing Yang, Hua Liao, Zhiheng Xu, Lindsey Tristine Hamblin, Long Jiang, Lieven Depypere, Keng Leong Ang, Jiaxi He, Ziyan Liang, Jun Huang, Jingpei Li, Qihua He, Wenhua Liang, Jianxing He
BACKGROUND: We aimed to summarize the diagnostic accuracy of white light bronchoscopy (WLB) and advanced techniques for airway pre-cancerous lesions and early cancer, such as autofluorescence bronchoscopy (AFB), AFB combined with WLB (AFB + WLB) and narrow-band imaging (NBI) bronchoscopy. METHODS: We searched for eligible studies in seven electronic databases from their date of inception to Mar 20, 2015. In eligible studies, detected lesions should be confirmed by histopathology...
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28063852/gait-speed-and-processing-speed-as-clinical-markers-for-geriatric-health-outcomes
#8
Joost B Sanders, Marijke A Bremmer, Hannie C Comijs, Peter M van de Ven, Dorly J H Deeg, Aartjan T F Beekman
OBJECTIVE: This study investigates the independent and combined potential of slowed gait speed and slowed processing speed as predictors of adverse health outcomes. The role of depressive symptoms in these associations is also investigated. METHODS: In the prospective cohort study, using the Longitudinal Aging Study Amsterdam database, three study samples for each outcome variable were defined: persistent cognitive decline (PCD; N = 1,271, 13 years of follow-up), falls (N = 1,282, 6 years of follow-up), and mortality (N = 1,559, age 74...
December 6, 2016: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28063796/pre-asymptotic-response-rates-as-a-function-of-the-delay-of-reinforcement-gradient-summation-for-catania-s-operant-reserve-a-reply-to-berg-mcdowell-2011
#9
Don Li, Douglas Elliffe, Michael J Hautus
Catania's Operant Reserve (COR; Catania, 2005) is a computational model of operant behaviour. In COR, responding depletes the reserve while reinforcement replenishes the reserve. The replenishment to the reserve depends on the location of responses within the most recent inter-reinforcement interval. The rule that maps replenishment to the responses within an inter-reinforcement interval is given by a delay-of-reinforcement gradient (DOR). Previous research (Berg and McDowell, 2011) found that non-linear DORs produce sigmoidal response rates on single variable-interval schedules while a linear DOR produces hyperbolic response rates...
January 4, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28063353/rationally-designed-benzopyran-fused-isoxazolidines-and-derived-%C3%AE-2-3-3-amino-alcohols-as-potent-analgesics-synthesis-biological-evaluation-and-molecular-docking-analysis
#10
Gagandeep Singh, Gurjit Singh, Rajbir Bhatti, Vivek Gupta, Ajay Mahajan, Palwinder Singh, Mohan Paul Singh Ishar
Based on structure activity analysis of morphine related opiates, we have synthesized some novel benzopyran fused isoxazolidines (2a-e) and derived conformationally constrained β(2,3,3)-amino alcohols (3a-e), which were evaluated in vivo for their anti-nociceptive activity through acetic acid induced writhing test (peripheral) and formalin induced algesia (central). Results showed that, compound 2a possesses significant opioid agonist activity. Further, molecular docking analysis reveals that compound 2a binds to δ-opioid receptor (DOR) with comparatively better D-score than to μ (MOR) and κ (KOR) receptors...
December 28, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28061391/associations-between-perceived-neighbourhood-problems-and-quality-of-life-in-older-adults-with-and-without-osteoarthritis-results-from-the-hertfordshire-cohort-study
#11
Erik J Timmermans, Suzan van der Pas, Laura A Schaap, Cyrus Cooper, Mark H Edwards, Catharine R Gale, Dorly J H Deeg, Elaine M Dennison
This study examined whether the association of quality of life (QoL) with perceived neighbourhood problems is stronger in older adults with osteoarthritis (OA) than in those without OA. Of all 294 participants, 23.8% had OA. More perceived neighbourhood problems were associated with a stronger decrease in QoL over time in participants with OA (B=-0.018; p=0.02) than in those without OA (B=-0.004; p=0.39). Physical activity did not mediate this relationship. Older adults with OA may be less able to deal with more challenging environments...
January 3, 2017: Health & Place
https://www.readbyqxmd.com/read/28060754/diagnostic-value-of-fib-4-for-liver-fibrosis-in-patients-with-hepatitis-b-a-meta-analysis-of-diagnostic-test
#12
Zhi Yin, Jin Zou, Qiongxuan Li, Lizhang Chen
This study is aimed at evaluating the diagnostic value of FIB-4 for liver fibrosis in patients with hepatitis B through a meta-analysis of diagnostic test. We conducted a comprehensive search in the Pubmed, Embase, Web of Science, and Chinese National Knowledge Infrastructure before October 31, 2016. Stata 14.0 software was used for calculation and statistical analyses. We used the sensitivity, specificity, positive and negative likelihood ratio (PLR, NLR), diagnostic odds ratio (DOR) and 95% confidence intervals (CIs) to evaluate the diagnostic value of FIB-4 for liver fibrosis in patients with hepatitis B...
January 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28058498/diagnostic-accuracy-of-dual-energy-ct-and-ultrasound-in-gouty-arthritis-a%C3%A2-systematic-review
#13
J Chen, M Liao, H Zhang, D Zhu
OBJECTIVE: The aim of our study was to compare the overall accuracy of ultrasonography (US), with at least one sign positive (double contour, tophus, aggregates), and dual-energy CT in the diagnosis of gouty arthritis. METHODS: PubMed, Web of Science, EI, Elsevier, Wiley Online Library and Cochrane library were systematically searched for studies on the diagnostic performance of dual-energy CT (DECT) and ultrasound (US) from 2005 to February 2016. After study selection, data and quality assessment, the sensitivity (SEN), specificity (SPE), diagnostic odds rate (DOR), positive likelihood ratio (PLR), negative likelihood ratio (NLR) and summary receiver operating contraction racteristic (SROC) curves were calculated...
January 5, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28056400/efficacy-and-safety-of-eribulin-as-first-to-third-line-treatment-in-patients-with-advanced-or-metastatic-breast-cancer-previously-treated-with-anthracyclines-and-taxanes
#14
Shigeto Maeda, Michiyo Saimura, Shigeki Minami, Kaname Kurashita, Reiki Nishimura, Yuichiro Kai, Hiroshi Yano, Kohjiro Mashino, Shoshu Mitsuyama, Mototsugu Shimokawa, Kazuo Tamura
OBJECTIVES: Despite the survival benefit and acceptable tolerability of eribulin for advanced/metastatic breast cancer (MBC) patients pretreated with anthracyclines and taxanes, there is limited evidence of the clinical benefit of early eribulin use. We investigated the efficacy and safety of first- to third-line eribulin use in patients with MBC. MATERIALS AND METHODS: In this phase II, open-label, single-arm study conducted at 14 sites in Kyushu, Japan, women with histologically confirmed human epidermal growth factor receptor 2-negative MBC were enrolled between December 1, 2011 and November 30, 2013 (Data cut-off: November 30, 2014)...
January 2, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28054892/primary-infected-left-ventricular-pseudoaneurysm-and-the-use-of-omental-flap
#15
Giorgio Maria Aru, Tad Kim, Roberto Giorgio Aru, Mary Carolyn Vinson
A 55-year-old man with autoimmune deficiency syndrome presented with an infected left ventricular pseudoaneurysm and sepsis. The aneurysmectomy consisted of a Dor-style pericardial patch plus debridement of the abscess cavities. The infected pseudoaneurysm recurred, much larger, within five months due to persistent infected abscess cavities. The second repair was done without a Dor-style patch and with an omental flap. No recurrence has occurred one year after the second repair, but the patient has asymptomatic, partial gastric herniation inside the pericardium...
December 1, 2016: Heart Surgery Forum
https://www.readbyqxmd.com/read/28039638/effects-of-laparoscopic-myotomy-on-the-esophageal-motility-pattern-of-esophageal-achalasia-as-measured-by-high-resolution-manometry
#16
Renato Salvador, Edoardo Savarino, Elisa Pesenti, Lorenzo Spadotto, Guerrino Voltarel, Giovanni Capovilla, Francesco Cavallin, Loredana Nicoletti, Michele Valmasoni, Alberto Ruol, Stefano Merigliano, Mario Costantini
BACKGROUND: Esophageal achalasia can be classified on the grounds of three distinct manometric patterns that correlate well with final outcome after laparoscopic Heller-Dor myotomy (LHM). No analytical data are available, however, on the postoperative picture and its possible correlation with final outcome. The aims of this study were: (a) to investigate whether manometric patterns change after LHM for achalasia; (b) to ascertain whether postoperative patterns and/or changes can predict final outcome; and (c) to test the hypothesis that the three known patterns represent different stages in the evolution of the disease...
December 30, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/28035528/delta-opioid-receptors-learning-and-motivation
#17
L P Pellissier, C N Pujol, J A J Becker, J Le Merrer
Delta opioid receptor (DOR) displays a unique, highly conserved, structure and an original pattern of distribution in the central nervous system, pointing to a distinct and specific functional role among opioid peptide receptors. Over the last 15 years, in vivo pharmacology and genetic models have allowed significant advances in the understanding of this role. In this review, we will focus on the involvement of DOR in modulating different types of hippocampal- and striatal-dependent learning processes as well as motor function, motivation, and reward...
December 30, 2016: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28024842/congenital-myasthenic-syndrome-in-israel-genetic-and-clinical-characterization
#18
Sharon Aharoni, Menachem Sadeh, Yehuda Shapira, Simon Edvardson, Muhannad Daana, Talia Dor-Wollman, Aviva Mimouni-Bloch, Ayelet Halevy, Rony Cohen, Liora Sagie, Zohar Argov, Malcolm Rabie, Ronen Spiegel, Ilana Chervinsky, Naama Orenstein, Andrew G Engel, Yoram Nevo
The objective of the study was to evaluate the epidemiology of patients with congenital myasthenic syndrome (CMS) in Israel. Targeted mutation analysis was performed based on the clinical symptoms and electrophysiological findings for known CMS. Additional specific tests were performed in patients of Iranian and/or Iraqi Jewish origin. All medical records were reviewed and clinical data, genetic mutations and outcomes were recorded. Forty-five patients with genetic mutations in known CMS genes from 35 families were identified...
November 24, 2016: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/28011222/benzylideneoxymorphone-a-new-lead-for-development-of-bifunctional-mu-delta-opioid-receptor-ligands
#19
Jason R Healy, Padmavani Bezawada, Nicholas W Griggs, Andrea L Devereaux, Rae R Matsumoto, John R Traynor, Andrew Coop, Christopher W Cunningham
Opioid analgesic tolerance remains a considerable drawback to chronic pain management. The finding that concomitant administration of delta opioid receptor (DOR) antagonists attenuates the development of tolerance to mu opioid receptor (MOR) agonists has led to interest in producing bifunctional MOR agonist/DOR antagonist ligands. Herein, we present 7-benzylideneoxymorphone (6, UMB 246) displaying MOR partial agonist/DOR antagonist activity, representing a new lead for designing bifunctional MOR/DOR ligands...
November 22, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28011159/the-impact-of-state-tort-reforms-on-imaging-utilization
#20
Suhui Li, Avi Dors, Darwyyn Deyo, Danny R Hughes
PURPOSE: Defensive medicine, broadly defined as medical practices that protect physicians from malpractice lawsuits without providing benefits to patients, can lead to wasteful use of health care resources and higher cost. Although physicians cite malpractice liability as an important factor driving their decisions to order imaging tests, little research has been done to examine the systematic impact of liability pressure on overall imaging. The authors examined the extent to which radiography use is influenced by malpractice liability pressure among office-based physicians...
December 20, 2016: Journal of the American College of Radiology: JACR
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