Yuliya E Borre, Theodora Panagaki, Pim J Koelink, Mary E Morgan, Hendrikus Hendriksen, Johan Garssen, Aletta D Kraneveld, Berend Olivier, Ronald S Oosting
Rising neurodegenerative and depressive disease prevalence combined with the lack of effective pharmaceutical treatments and dangerous side effects, has created an urgent need for the development of effective therapies. Considering that these disorders are multifactorial in origin, treatments designed to interfere at different mechanistic levels may be more effective than the traditional single-targeted pharmacological concepts. To that end, an experimental diet composed of zinc, melatonin, curcumin, piperine, eicosapentaenoic acid (EPA, 20:5, n-3), docosahexaenoic acid (DHA, 22:6, n-3), uridine, and choline was formulated...
April 2014: Neuropharmacology