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Kentucky st198

Bradd J Haley, Seon Woo Kim, James Pettengill, Yan Luo, Jeffrey S Karns, Jo Ann S Van Kessel
Salmonella enterica subsp. enterica serovar Kentucky is frequently isolated from healthy poultry and dairy cows and is occasionally isolated from people with clinical disease. A genomic analysis of 119 isolates collected in the United States from dairy cows, ground beef, poultry and poultry products, and human clinical cases was conducted. Results of the analysis demonstrated that the majority of poultry and bovine-associated S. Kentucky were sequence type (ST) 152. Several bovine-associated (n = 3) and food product isolates (n = 3) collected from the United States and the majority of human clinical isolates were ST198, a sequence type that is frequently isolated from poultry and occasionally from human clinical cases in Northern Africa, Europe and Southeast Asia...
2016: PloS One
Dariusz Wasyl, Izabela Kern-Zdanowicz, Katarzyna Domańska-Blicharz, Magdalena Zając, Andrzej Hoszowski
Multidrug resistant Salmonella Kentucky strains have been isolated from turkeys in Poland since 2009. Multiple mutations within chromosomal genes gyrA and parC were responsible for high-level ciprofloxacin resistance. One of the isolates was extended spectrum β-lactamase- (ESBL) positive: the strain 1643/2010 carried a conjugative 167,779 bps plasmid of IncA/C family. The sequence analysis revealed that it carried a blaCTX-M-25 gene and an integron with another β-lactamase encoding gene-blaOXA-21. This is the first known report of a CTX-M-25 encoding gene both in Poland and in Salmonella Kentucky world-wide, as well as in the IncA/C plasmid...
January 30, 2015: Veterinary Microbiology
Salome N Seiffert, Vincent Perreten, Sönke Johannes, Sara Droz, Thomas Bodmer, Andrea Endimiani
Here, we report a case of OXA-48-producing Salmonella enterica serovar Kentucky of sequence type 198 (ST198) from perianal screening cultures of a patient transferred from Libya to Switzerland. The blaOXA-48 gene was carried by Tn1999.2 and located on an ∼60-kb IncL/M plasmid. This Salmonella strain also possessed the blaVEB-8, aac(6)-Ib, tet(A), sul1, and mphA resistance genes and substitutions in GyrA (Ser83Phe and Asp87Asn) and ParC (Ser80Ile). This finding emphasizes that prompt screening strategies are essential to prevent the dissemination of carbapenemase producers imported from countries where they are endemic...
2014: Antimicrobial Agents and Chemotherapy
Simon Le Hello, Amany Bekhit, Sophie A Granier, Himel Barua, Janine Beutlich, Magdalena Zając, Sebastian Münch, Vitali Sintchenko, Brahim Bouchrif, Kayode Fashae, Jean-Louis Pinsard, Lucile Sontag, Laetitia Fabre, Martine Garnier, Véronique Guibert, Peter Howard, Rene S Hendriksen, Jens P Christensen, Paritosh K Biswas, Axel Cloeckaert, Wolfgang Rabsch, Dariusz Wasyl, Benoit Doublet, François-Xavier Weill
While the spread of Salmonella enterica serotype Kentucky resistant to ciprofloxacin across Africa and the Middle-East has been described recently, the presence of this strain in humans, food, various animal species (livestock, pets, and wildlife) and in environment is suspected in other countries of different continents. Here, we report results of an in-depth molecular epidemiological study on a global human and non-human collection of S. Kentucky (n = 70). We performed XbaI-pulsed field gel electrophoresis and multilocus sequence typing, assessed mutations in the quinolone resistance-determining regions, detected β-lactam resistance mechanisms, and screened the presence of the Salmonella genomic island 1 (SGI1)...
2013: Frontiers in Microbiology
Himel Barua, Paritosh Kumar Biswas, Kaisar Ali Talukder, Katharina E P Olsen, Jens Peter Christensen
We investigated Salmonella enterica isolates from human clinical cases of gastroenteritis to determine the distribution of non-typhoidal Salmonella serovars in the human population, and compared them to isolates originating from poultry by serotyping, phage typing, plasmid profiling, pulsed-field gel electrophoresis (PFGE) and multi-locus sequence typing (MLST) to evaluate the potential role of poultry in human non-typhoidal salmonellosis in Bangladesh. Nine different serovars were identified among the human isolates of which Salmonella Paratyphi B var Java (S...
January 31, 2014: Veterinary Microbiology
Sylvie Baucheron, Simon Le Hello, Benoît Doublet, Etienne Giraud, François-Xavier Weill, Axel Cloeckaert
A screening for non-target mutations affecting fluoroquinolone susceptibility was conducted in epidemic multidrug-resistant Salmonella enterica serovar Kentucky ST198. Among a panel of representative isolates (n = 27), covering the epidemic, only three showed distinct mutations in ramR resulting in enhanced expression of genes encoding the AcrAB-TolC efflux system and low increase in ciprofloxacin MIC. No mutations were detected in other regulatory regions of this efflux system. Ciprofloxacin resistance in serovar Kentucky ST198 is thus currently mainly due to multiple target gene mutations...
2013: Frontiers in Microbiology
Michael R Mulvey, David A Boyd, Rita Finley, Ken Fakharuddin, Stacie Langner, Vanessa Allen, Lei Ang, Sadjia Bekal, Sameh El Bailey, David Haldane, Linda Hoang, Greg Horsman, Marie Louis, Lourens Robberts, John Wylie
We report emergence of ciprofloxacin-resistant Salmonella enterica serovar Kentucky in Canada during 2003-2009. All isolates had similar macrorestriction patterns and were multilocus sequence type ST198, which has been observed in Europe and Africa. Ciprofloxacin-resistant S. enterica serovar Kentucky represents 66% of all ciprofloxacin-resistant nontyphoidal Salmonella sp. isolates observed in Canada since 2003.
June 2013: Emerging Infectious Diseases
Simon Le Hello, Dorothée Harrois, Brahim Bouchrif, Lucile Sontag, Dalèle Elhani, Véronique Guibert, Khalid Zerouali, François-Xavier Weill
BACKGROUND: Salmonella enterica is a major global food-borne pathogen, causing life-threatening infections. Ciprofloxacin and extended-spectrum cephalosporins (ESCs) are the drugs of choice for severe infections. We previously reported a ciprofloxacin-resistant S. enterica serotype Kentucky (S Kentucky) ST198-X1 strain that emerged in Egypt and spread throughout Africa and the Middle East from 2002 to 2008. We aimed to monitor recent trends in the location of transmission and antimicrobial resistance of this strain...
August 2013: Lancet Infectious Diseases
Simon Le Hello, François-Xavier Weill, Véronique Guibert, Karine Praud, Axel Cloeckaert, Benoît Doublet
Salmonella genomic island 1 (SGI1) is a 43-kb integrative mobilizable element that harbors a great diversity of multidrug resistance gene clusters described in numerous Salmonella enterica serovars and also in Proteus mirabilis. The majority of SGI1 variants contain an In104-derivative complex class 1 integron inserted between resolvase gene res and open reading frame (ORF) S044 in SGI1. Recently, the international spread of ciprofloxacin-resistant S. enterica serovar Kentucky sequence type 198 (ST198) containing SGI1-K variants has been reported...
October 2012: Antimicrobial Agents and Chemotherapy
Michel M Dione, Stanny Geerts, Martin Antonio
INTRODUCTION: Non-typhoidal Salmonella (NTS) contamination in poultry and poultry products is a major cause of food-borne disease in humans. This study presents the molecular epidemiology of NTS isolated from poultry in Senegal. METHODOLOGY: A total of 261 NTS recovered from broiler farms, chicken carcasses and street vendors were characterized using random amplification of polymorphic DNA (RAPD) and multilocus sequence typing (MLST) techniques. RESULTS: We observed 20 distinct RAPD profiles corresponding to 18 different serotypes...
May 2012: Journal of Infection in Developing Countries
Janine Beutlich, Beatriz Guerra, Andreas Schroeter, Mardjan Arvand, Istvan Szabo, Reiner Helmuth
In recent years in France, England, Wales, Denmark and the USA about 500 human infections occurred, which were caused by multidrug-resistant Salmonella enterica Serovar (S.) Kentucky isolates displaying high-level resistance to fluoroquinolones (ciprofloxacin, MIC > or = 4 mg/l). The responsible clone was referred to as ST198-X1.To determine whether this clone is also present in German S. Kentucky isolates, the National Reference Laboratory for Salmonella (NRL-Salm) at the BfR analyzed the trend of S. Kentucky isolates received over the past years...
March 2012: Berliner und Münchener Tierärztliche Wochenschrift
Simon Le Hello, Rene S Hendriksen, Benoît Doublet, Ian Fisher, Eva Møller Nielsen, Jean M Whichard, Brahim Bouchrif, Kayode Fashae, Sophie A Granier, Nathalie Jourdan-Da Silva, Axel Cloeckaert, E John Threlfall, Frederick J Angulo, Frank M Aarestrup, John Wain, François-Xavier Weill
National Salmonella surveillance systems from France, England and Wales, Denmark, and the United States identified the recent emergence of multidrug-resistant isolates of Salmonella enterica serotype Kentucky displaying high-level resistance to ciprofloxacin. A total of 489 human cases were identified during the period from 2002 (3 cases) to 2008 (174 cases). These isolates belonged to a single clone defined by the multilocus sequence type ST198, the XbaI-pulsed-field gel electrophoresis cluster X1, and the presence of the Salmonella genomic island 1 variant SGI1-K...
September 1, 2011: Journal of Infectious Diseases
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