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JOURNAL ARTICLE
A Lazarovich, T Drori, Y Guttman, B Rosenzweig, A Ben-Yaaqov, J Korach, A Nissan, Z A Dotan
BACKGROUND: Pelvic exenteration (PE) is a major surgical procedure used as a salvage therapy for patients with locally advanced or recurrent pelvic malignancies. Urinary reconstruction is a major part of PE and is often associated with high rates of post-operative complications. In the current study we evaluate the short and long-term urological outcomes following PE for Colo-Rectal (CR) and gyneco-oncological (GO) malignancies. METHODS: Study included 22 patients who underwent PE for recurrent or locally advanced CR and GO malignancies in our institution between the years 2010-2018...
April 30, 2024: Heliyon
#2
JOURNAL ARTICLE
H Hafiani, N Bouknani, E M Choukri, R Charif Saibari, A Rami
BACKGROUND: Gas extravasation complications arising from perforated diverticulitis are common but manifestations such as pneumoperitoneum, pneumoretroperitoneum, and pneumomediastinum happening at the same time are exceedingly rare. This case report explores the unique presentation of these 3 complications occurring simultaneously, their diagnosis and their management, emphasizing the importance of interdisciplinary collaboration for accurate diagnosis and effective management. CASE PRESENTATION: A 74-year-old North African female, with a medical history including hypertension, dyslipidemia, type 2 diabetes, goiter, prior cholecystectomy, and bilateral total knee replacement, presented with sudden-onset pelvic pain, chronic constipation, and rectal bleeding...
April 17, 2024: Journal of Medical Case Reports
#3
JOURNAL ARTICLE
Stefano Di Sandro, Deniz Balci, Fabrizio Di Benedetto
Liver transplantation (LT) revolutionized the outlook for cirrhotic patients, offering a potential cure with over 80% life expectancy after 5 years. Cirrhosis, with or without hepatocellular carcinoma (HCC), is the primary LT indication. Living donor LT (LDLT) initially explored as an alternative, declined due to poorer outcomes. Studies on LDLT improved outcomes through precise recipient selection, emphasizing the importance of careful donor/recipient matching. Emerging concepts like left lobe preference and minimally invasive donor approaches enhance LDLT outcomes...
April 9, 2024: Updates in Surgery
#4
Francesco Marrone, Pierfrancesco Fusco, Luca Lepre, Michela Giulii Capponi, Alessandra Villani, Saverio Paventi, Marco Tomei, Roberto Starnari, Carmine Pullano
We present the case of a successful application of combined spinal-epidural anesthesia for a geriatric patient undergoing open cancer surgery. The patient, affected by multiple comorbidities, was proposed for an open anterior rectal resection. The implementation of a tailored protocol, incorporating neuraxial techniques such as epidural and spinal anesthesia, facilitated optimal pain management and expedited postoperative recovery improving perioperative outcomes, and highlighting the potential benefits of such strategies in selected cases...
March 2024: Curēus
#5
Maria Alessandra Bellia, Carmelo Sofia, Maria Adele Marino, Carmelo Mazzeo, Santino Antonio Biondo, Eugenio Cucinotta, Francesco Fleres
Regorafenib is a multikinase inhibitor approved for treatment of patients with metastatic Colo-Rectal Cancer (mCRC) and Gastro-Intestinal Stromal Tumor (GIST) progression after the administration of other tyrosine-kinase inhibitors such as imatinib and sunitinib. Only a handful of severe side effects such as intestinal perforations and fistulas have been described in the literature in patients undergoing multikinase inhibitor treatment. We report a case of a patient with peritoneal mCRC who experienced an intestinal perforation during the administration of Regorafenib and review the literature...
May 2024: Radiology Case Reports
#6
Malvina Asbah, Oadi N Shrateh, Hadeel Ashqar, Asil Musleh, Khaled Abbadi, Wael Amro
INTRODUCTION: Waugh's syndrome, characterized by the concurrent presence of acute intussusception and gut malrotation, is a rare clinical entity. The relationship between these conditions is not well-explored, and the true incidence may be underreported. CASE PRESENTATION: A 4 month old male infant, with an uneventful medical history, presented to the pediatric emergency department due to irritability and rectal bleeding lasting one day. The infant had a history of bilious vomiting and dark bloody rectal discharge...
February 20, 2024: International Journal of Surgery Case Reports
#7
JOURNAL ARTICLE
Anuj Goyal, Anvin Mathew, Princy Joseph, Gourav Kaushal, Nirjhar R Rakesh, Puneet Dhar
INTRODUCTION: Multiple reconstructive techniques have been described for reconstruction after a low anterior resection for carcinoma rectum. Colonic J pouch (CJP), Side to end anastomosis (SEA), transverse coloplasty pouch (TCP) and Straight Colo-rectal/anal anastomosis were the most widely studied. EVIDENCE ACQUISITION: PubMed, Embase and Cochrane data base were searched for randomized, non-randomized studies and systematic reviews from inception of the databases till July 31st , 2023...
February 2024: Minerva surgery
#8
REVIEW
L Spindler, I Etienney, L Abramowitz, V de Parades, F Pigot, L Siproudhis, J Adam, V Balzano, D Bouchard, N Bouta, M Bucau, A Carlo, J Chanal, C Charpentier, G Clifford, M Draullette, N Fathallah, V Ferré, J-F Fléjou, S Fouéré, T Higuero, L Kassouri, S Kurt, A Laurain, E Leclerc, Q Lepiller, A-C Lesage, D Mège, A Ménard, P Merle, P Mortreux, C Noël, H Péré, J-L Prétet, D Roland, G Staumont, L Tracanelli, L Vuitton, S Wylomanski, O Zaegel-Faucher
In France, about 2000 new cases of anal cancer are diagnosed annually. Squamous cell carcinoma is the most common histological type, mostly occurring secondary to persistent HPV16 infection. Invasive cancer is preceded by precancerous lesions. In addition to patients with a personal history of precancerous lesions and anal cancer, three groups are at very high risk of anal cancer: (i) men who have sex with men and are living with HIV, (ii) women with a history of high-grade squamous intraepithelial lesions (HSILs) or vulvar HPV cancer, and (iii) women who received a solid organ transplant more than 10 years ago...
January 10, 2024: Techniques in Coloproctology
#9
Mohamed Ali Chaouch, Rim Sallem, Sadok Ben Jabra, Eya Chedly, Besma Gafsi, Faouzi Noomen
INTRODUCTION AND IMPORTANCE: Strangled rectal prolapse (RP), also known as incarcerated rectal prolapse, is a condition where the RP cannot be manually reduced. CASE PRESENTATION: This case report describes a 48-year-old man presenting with a painful and irreducible rectal prolapse. Following failed attempts at manual reduction and the development of necrosis, emergency surgery was performed using the Altemeier procedure. This surgical technique involves resection of the rectum and colon, followed by colo-anal anastomosis and a protective ileostomy...
December 31, 2023: International Journal of Surgery Case Reports
#10
JOURNAL ARTICLE
Paul Little, Katherine Bradbury, Beth Stuart, Jane Barnett, Adele Krusche, Mary Steele, Elena Heber, Steph Easton, Kirsten Ailsa Smith, Joanna Slodkowska-Barabasz, Liz Payne, Teresa Corbett, Guiqing Yao, Sebastien Pollet, Jazzine Smith, Judith Joseph, Megan Lawrence, Dankmar Bohning, Tara Cheetham-Blake, Diana Eccles, Claire Foster, Adam W A Geraghty, Geraldine Leydon, Andre Muller, Richard Neal, Richard Osborne, Shanaya Rathod, Alison Richardson, Chloe Grimmett, Geoff Sharman, Roger Bacon, Lesley Turner, Richard Stephens, Tamsin Burford, Laura Wilde, Karen Middleton, Megan Liddiard, Kirsty Rogers, James Raftery, Shihua Zhu, Fran Webley, Gareth Griffiths, Jaqui Nutall, Trudie Chalder, Clare E Wilkinson, Eila Watson, Lucy Yardley
BACKGROUND: Many cancer survivors following primary treatment have prolonged poor quality of life. AIM: To determine the effectiveness of a bespoke digital intervention to support cancer survivors. DESIGN: Pragmatic parallel open randomised trial. SETTING: UK general practices. METHODS: People having finished primary treatment (<= 10 years previously) for colo-rectal, breast or prostate cancers, with European-Organization-for-Research-and-Treatment-of-Cancer QLQ-C30 score <85, were randomised by online software to: 1)detailed 'generic' digital NHS support ('LiveWell';n=906), 2) a bespoke complex digital intervention ('Renewed';n=903) addressing symptom management, physical activity, diet, weight loss, distress, or 3) 'Renewed-with-support' (n=903): 'Renewed' with additional brief email and telephone support...
December 20, 2023: British Journal of General Practice
#11
JOURNAL ARTICLE
Giacomo Sermonesi, Brian W C A Tian, Carlo Vallicelli, Fikri M Abu-Zidan, Dimitris Damaskos, Michael Denis Kelly, Ari Leppäniemi, Joseph M Galante, Edward Tan, Andrew W Kirkpatrick, Vladimir Khokha, Oreste Marco Romeo, Mircea Chirica, Manos Pikoulis, Andrey Litvin, Vishal Girishchandra Shelat, Boris Sakakushev, Imtiaz Wani, Ibrahima Sall, Paola Fugazzola, Enrico Cicuttin, Adriana Toro, Francesco Amico, Francesca Dal Mas, Belinda De Simone, Michael Sugrue, Luigi Bonavina, Giampiero Campanelli, Paolo Carcoforo, Lorenzo Cobianchi, Federico Coccolini, Massimo Chiarugi, Isidoro Di Carlo, Salomone Di Saverio, Mauro Podda, Michele Pisano, Massimo Sartelli, Mario Testini, Andreas Fette, Sandro Rizoli, Edoardo Picetti, Dieter Weber, Rifat Latifi, Yoram Kluger, Zsolt Janos Balogh, Walter Biffl, Hans Jeekel, Ian Civil, Andreas Hecker, Luca Ansaloni, Francesca Bravi, Vanni Agnoletti, Solomon Gurmu Beka, Ernest Eugene Moore, Fausto Catena
BACKGROUND: Laparoscopy is widely adopted across nearly all surgical subspecialties in the elective setting. Initially finding indication in minor abdominal emergencies, it has gradually become the standard approach in the majority of elective general surgery procedures. Despite many technological advances and increasing acceptance, the laparoscopic approach remains underutilized in emergency general surgery and in abdominal trauma. Emergency laparotomy continues to carry a high morbidity and mortality...
December 8, 2023: World Journal of Emergency Surgery: WJES
#12
JOURNAL ARTICLE
Octavian Adrian Maghiar, Mircea Şandor, Mădălina-Andrada Blaj, Marius Belean, Andrei Ardelean, Violeta Turcuş, Teodor Andrei Maghiar, Adina Pop-Moldovan, Endre Mathe, Alin Bodog, Carmen Neamţu, Cristina-Adriana Dehelean, Ovidiu Laurean Pop, Bogdan Dan Totolici, Andreea-Adriana Neamţu
Background: Colorectal cancer, 3rd in incidence and 2nd in mortality among cancers worldwide, represents the most common malignant tumor of the digestive tract. In Romania, it is the most frequently diagnosed type of cancer (approximately 0.06% of the population/year). During the COVID-19 pandemic the legislation preventing the SARS-CoV-2 viral transmission impairing access to outpatient healthcare services combined with patients fear of SARS-CoV-2 infection had consequences on the diagnosis and treatment of all other pathologies...
October 2023: Chirurgia
#13
MULTICENTER STUDY
Serge Evrard, Carine Bellera, Gregoire Desolneux, Coralie Cantarel, Emilie Toulza, Jean-Luc Faucheron, Michel Rivoire, Aurélien Dupré, Jean-Yves Mabrut, Laurent Bresler, Frédéric Marchal, Damien Bouriez, Eric Rullier
BACKGROUND: Anastomotic leakage (AL) remains a major cause of morbidity following total mesorectal excision (TME). A diverting ileostomy reduces the risk of AL but impairs quality of life (QoL). Delayed colo-anal anastomosis (DCAA) may be an alternative to immediate colo-anal anastomosis (ICAA) without creation of a diverting ileostomy. STUDY DESIGN: Patients with T3 or N+ rectal tumours were treated with neoadjuvant chemoradiation and TME. To evaluate DCAA or ICAA with diverting ileostomy, a two multicenter single-arm phase II trials was designed...
November 2023: European Journal of Surgical Oncology
#14
JOURNAL ARTICLE
Greta Leitz-Najarian, Melissa Najarian
OBJECTIVE: To analyze the risk and benefit of bowel preparations in elective colo-rectal surgery. BACKGROUND: Mechanical bowel preparations (MBPs) have been popularized in colo-rectal surgery since studies in the 1970s, but recent data has called their use into question and examined complication rates between patients with and without bowel preparations. METHODS: A retrospective case-review was performed consisting of 1237 elective colo-rectal surgeries performed by two surgeons between 2008 and 2021...
November 2023: American Surgeon
#15
JOURNAL ARTICLE
Michael Jaffe, Kayla Alexander, Michelle Ryan, Blair Bennett, Brittany Baughman
A 4 mo old male goldendoodle puppy was evaluated for chronic hematochezia with a history of recurrent rectal prolapse and tenesmus. A colo-colonic intussusception was diagnosed via abdominal imaging. Surgery was elected to reduce the intussusception, wherein a colonic mass was discovered. Colonic resection and anastomosis was performed, and the tissue were submitted for histopathological examination. The puppy was diagnosed with colonic hamartomatous ganglioneuromatosis based on the presence of markedly hyperplastic submucosal and myenteric plexi with infiltration and expansion of the mucosa and submucosa by Schwann cells and neuronal cell bodies...
September 1, 2023: Journal of the American Animal Hospital Association
#16
JOURNAL ARTICLE
Radhey Patel, Prince C Akahara, Mohammed Raaid O Musa, Obiamaka P Okereke, Chander Puri, Saare Abera, Obiaku U Okoronkwo, Joy Iroro, Abigail O Dan-Eleberi, Okelue E Okobi, Ogechukwu Nwachukwu
BACKGROUND: Individuals with different mental disorders tend to experience higher rates of colorectal cancer (CRC)-related mortality compared to the general population. Discrepancies in CRC screening behaviors have been suggested as a potential contributing factor to this difference in mortality. However, existing evidence on this topic has been inconclusive and conflicting. OBJECTIVE: This study aims to explore the relationship between mental health status (specifically, depression and/or anxiety) and the uptake of CRC screening...
July 2023: Curēus
#17
JOURNAL ARTICLE
Laurenţiu Simion, Vlad Rotaru, Simona Cirimbei, Elena Chitoran, Laurenţia Galeş, Dan Cristian Luca, Sînziana Ionescu, Bogdan Tanase, Octav Ginghină, Alecu Mihnea, Silviu Voinea, Andra Bîrligea, Horia Doran, Ciprian Cirimbei
Introduction: Management of synchronous colorectal cancer with liver metastases (SCLM) is still on debate, regarding timing, indications and complications of the 3 strategies: classic approach (first tumor resection), simultaneous resection and reverse approach (liver first). A retrospective single-centre evaluation of synchronous approach was accomplished, focusing on surgical technique, indications and complications. Material and Methods: Between 2017 and 2020, 31 SCLM patients benefited from synchronously colorectal and hepatic approach: segmental colectomies/rectal resections, simultaneously with liver metastasectomies (associated with radiofrequency ablation)...
June 2023: Chirurgia
#18
JOURNAL ARTICLE
Philip B C Pang, Ashvina Chouhan, Heman M N Joshi, James M D Wheeler, Gareth D Corbett, Sibu Varghese, Edmund M Godfrey
AIM: The incidence of benign colonic anastomotic stricture is approximately 2% in patients undergoing left hemicolectomy or anterior resection and as high as 16% in patients undergoing low anterior or intersphincteric resection. In the majority, rather than complete occlusion, a stenosis forms, which can be managed with endoscopic balloon dilatation, a self-expanding metallic stent or endoscopic electroincision. In the less common scenario of a completely occluded colonic anastomosis, surgery is often required...
July 11, 2023: Colorectal Disease
#19
JOURNAL ARTICLE
William Franceschi, Jonathan Bliggenstorfer, Anuja L Sarode, Meridith Ginesi, Emily Steinhagen, Sharon L Stein
Introduction Although rectal cancer is thought to have a higher rate of metastasis to the brain compared with colon cancer, there is limited and contradictory data on the subject. This study aims to determine the prevalence of brain metastasis for colon and rectal cancers (CRC), and to explore associations and predictors of brain metastasis (BM). Methods The 2010-2016 National Cancer Database (NCDB) was queried for patients with stage IV CRC. Patients with missing data on site of metastasis and primary tumor location were excluded...
May 2023: Curēus
#20
REVIEW
Irene Mignini, Maria Elena Ainora, Silvino Di Francesco, Linda Galasso, Antonio Gasbarrini, Maria Assunta Zocco
Colo-rectal cancer (CRC) is undoubtedly one of the most severe complications of inflammatory bowel diseases (IBD). While sporadic CRC develops from a typical adenoma-carcinoma sequence, IBD-related CRC follows different and less understood pathways and its pathophysiological mechanisms were not completely elucidated. In contrast to chronic inflammation, which is nowadays a well-recognised drive towards neoplastic transformation in IBD, only recently was gut microbiota demonstrated to interfere with both inflammation processes and immune-mediated anticancer surveillance...
June 15, 2023: Cancers
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