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Nerve sheath myxoma

Alex C Tham, Nandini L Chilagondanahalli, Manish M Bundele, Jeevendra Kanagalingam
Oral neurothekeoma or nerve sheath myxoma is a rare benign oral tumour of nerve sheath origin. Historically, this tumour has been subclassified as myxoid (classic), mixed, or the cellular type, depending on the amount of myxoid stroma and cellularity. We present a case of oral neurothekeoma (mixed type) of the buccal mucosa. The tumour was completely excised. No recurrence was detected in the last 3 years after local excision.
2016: Case Reports in Otolaryngology
Şule Güngör, Servet Şişman, Emek Kocaturk, Ilteris Oguz Topal, Selda Yıldırım
Herein we present the case of a 16-month boy, clinically diagnosed with infantile digital fibromatosis, but 9 months after continued growth, the mass was excised and the histopathologic diagnosis was that of a benign nerve sheath myxoma. We present this case to emphasize that nerve sheath myxomas (also known as myxoid neurothekeoma) should be included in the differential diagnosis of dermal nodules in infants.
July 2016: Pediatric Dermatology
Eric J Yang, Jason L Hornick, Xiaohua Qian
BACKGROUND: Soft tissue perineurioma (STP) is a benign peripheral nerve sheath tumor demonstrating uniform perineurial cell differentiation. To the authors' knowledge, the cytomorphologic features of STP remain incompletely characterized, and the distinction between STP and its benign (intramuscular/cellular myxoma) and malignant (low-grade fibromyxoid sarcoma [LGFMS]) mimics is challenging. METHODS: Fine-needle aspiration (FNA)/core needle biopsies of 25 low-grade myxoid spindle cell neoplasm cases including STP (5 cases), intramuscular/cellular myxoma (16 cases), and LGFMS (4 cases) were reviewed retrospectively for cytomorphologic and immunophenotypic comparison...
September 2016: Cancer Cytopathology
Y I Ding, Fan Zou, Weixia Peng, Min Dai, Houyun Gu, Bin Zhang, Tao Nie
Neurothekeoma is a rare myxoma of the peripheral nerve sheath. The current report presents a case of a giant neurothekeoma with a partially-formed capsule, scapula erosion and unclear biological behavior, which originated in the intermuscular space between the left trapezius muscle and scapula. The patient was initially misdiagnosed with a fibromatosis using computed tomography and magnetic resonance image scanning. Diagnosis of the neoplasm was confirmed by pathological and immunohistochemical examination, revealing a neurothekeoma with unclear biological behavior...
February 2016: Oncology Letters
Manuel Röhrich, Christian Koelsche, Daniel Schrimpf, David Capper, Felix Sahm, Annekathrin Kratz, Jana Reuss, Volker Hovestadt, David T W Jones, Melanie Bewerunge-Hudler, Albert Becker, Joachim Weis, Christian Mawrin, Michel Mittelbronn, Arie Perry, Victor-Felix Mautner, Gunhild Mechtersheimer, Christian Hartmann, Ali Fuat Okuducu, Mirko Arp, Marcel Seiz-Rosenhagen, Daniel Hänggi, Stefanie Heim, Werner Paulus, Jens Schittenhelm, Rezvan Ahmadi, Christel Herold-Mende, Andreas Unterberg, Stefan M Pfister, Andreas von Deimling, David E Reuss
The vast majority of peripheral nerve sheath tumors derive from the Schwann cell lineage and comprise diverse histological entities ranging from benign schwannomas and neurofibromas to high-grade malignant peripheral nerve sheath tumors (MPNST), each with several variants. There is increasing evidence for methylation profiling being able to delineate biologically relevant tumor groups even within the same cellular lineage. Therefore, we used DNA methylation arrays for methylome- and chromosomal profile-based characterization of 171 peripheral nerve sheath tumors...
June 2016: Acta Neuropathologica
Hillary Elwood, Janis Taube
This article presents an overview of soft tissue tumors that have a plexiform histomorphology. The more commonly encountered entities, including plexiform fibrohistiocytic tumor, cellular neurothekeoma, dermal nerve sheath myxoma, plexiform schwannoma, and plexiform neurofibroma, are discussed in detail, and other tumors are noted. Information on clinical features, microscopic findings, ancillary studies, differential diagnosis, and prognosis is provided for each entity.
September 2011: Surgical Pathology Clinics
Ashley M Cimino-Mathews
This article presents an overview of the diagnostic categories of benign and malignant nerve sheath tumors, including neuroma, neurofibroma, nerve sheath myxoma, perineurioma, schwannoma, and malignant peripheral nerve sheath tumor. The discussion emphasizes histologic patterns; ancillary studies, such as immunohistochemistry; and differential diagnoses. The information is of value to practicing pathologists in both community and academic settings.
September 2011: Surgical Pathology Clinics
Tae Young Han, Byeol Han, Young Chae Lee, June Hyunkyung Lee, Sook-Ja Son
Neurothekeoma (nerve sheath myxoma)is a benign tumor of probable nerve sheath origin. The atypical cellular variant of this tumor, showing a peculiar histologic pattern, has been very rarely reported in the literature. The atypical variant of cellular neurothekeoma is characterized by features such as large size, deep penetration extending into skeletal muscle and/or subcutaneous fat, diffuse infiltration borders, vascular invasion, high mitotic rate and marked cytologic pleomorphism. We describe a rare form of atypical myxoid cellular neurothekeoma in a 6-year-old girl...
March 2016: Pediatric Dermatology
Sudheer Arava, Saphalta Bagmar, Parul Jain, Muthu Kumaran, Sanjeev Kumar, Ruma Ray
Myxomas are the most common benign cardiac tumors constituting approximately 75% of all the cardiac tumors. Rest 25% are malignant and sarcomas being the commonest. Among the sarcomas primary cardiac malignant peripheral nerve sheath tumors are extremely rare. They usually arise in relation to the branches of vagus or phrenic nerves, 5-42% being associated with neurofibromatosis type 1. Clinical signs and symptoms depend on the location and extent of involvement. Complete resection is the treatment of choice but local recurrence is common...
October 2015: Indian Journal of Pathology & Microbiology
Cristián Navarrete-Dechent, Maximiliano Curi-Tuma, Celeste Marín, Sergio González, Mauricio Sandoval-Osses
Neurothekeoma is an uncommon, benign neoplasm presenting in young adults, primarily on the head and neck. It was initially related to nerve sheath myxoma but with the advent of immunohistochemistry, new insights into its cellular differentiation and origin have emerged, unlinking Neurothekeoma and nerve sheath myxoma. Herein we describe a 19-year-old male who had had a frontal, flesh-colored, asymptomatic papule for 2 years. Histology showed a dermal fusocellular-spindle cell tumor, including an eosinophilic cytoplasm with mild cellular pleomorphism and moderately dense fibrous stroma...
May 2015: Anais Brasileiros de Dermatologia
Amoolya Bhat, Apaparna Narasimha, Vijaya C, Sundeep Vk
Nerve sheath myxoma defined by Harkin and Reed is an uncommon benign neoplasm with nerve sheath like features. It has several cytological and histological differential diagnoses. One such lesion is neurothekeoma, which can be differentiated using immunohistochemistry. In most of the previous reports nerve sheath myxoma and neurothekeoma were considered synonymous and were often confused for one another. This case report separates the two using immunohistochemistry. Also, the cytological features of nerve sheath myxoma are not well documented in the past...
April 2015: Journal of Clinical and Diagnostic Research: JCDR
R A Onoprienko, S Iu Timonin, N A Konovalov, L V Shishkina, A G Nazarenko, D S Asiutin, M A Martynova, V A Korolishin
Myxoma of the peripheral nerve sheath is a rare benign tumor with predominant localization in the upper extremities, head, neck, and chest. In this study, we reported a clinical case of a patient with intradural myxoma at the L1 level. Much attention was given to histological characterization of the tumor and differential diagnosis of histological types of benign extramedullary tumors. A conclusion was drawn that patients with myxoma need further thorough examination as there is a risk of generalization of tumor process...
2014: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
Genevieve Staudt, William Camann
Carney complex is an autosomal dominant condition with widespread manifestations, including cardiac myxomas, nerve sheath tumors, and endocrinopathies. Although often associated with infertility, there are several reports of successful pregnancies in patients with Carney complex. However, none of the previous reports describe anesthetic considerations. Herein, we present a patient with Carney complex who successfully delivered vaginally with labor epidural analgesia.
January 1, 2015: A & A Case Reports
Melih Malkoc, Tugrul Ormeci, Mert Keskinbora, Adem Yılmaz, Ozgur Korkmaz, Canan Besleyici Tanik
INTRODUCTION: Nerve sheath myxomas (NSM) are rare benign soft tissue tumors. The dorsal paravertebral placed NMS diagnosis can be difficult. PRESENTATION OF CASE: This article presents clinical, radiological findings and treatment of the NSM of the dorsal paravertebral space in a 32-year-old man presented with a right shoulder and back pain for 4 years. DISCUSSION: NSM is a rare and benign tumor and that most often occurs in the skin of the head, neck or upper limbs of younger patients...
2014: International Journal of Surgery Case Reports
Muhammet Sayan, Ali Celik, Onur Ertunc, Omer Uluoglu, Abdullah Irfan Tastepe
Neurothekeoma, also known as nerve sheath myxoma, is a benign nerve sheath tumor that usually arises in the cutaneous nerves of the head, neck, or upper extremities. Extracutaneous placement is very rare. Mediastinal neurothekeoma has not previously been reported in the English literature. A 30-year-old woman was admitted to our clinic with back pain. A smooth-edged mass found in her paravertebral region, and a neurogenic tumor was suspected. The tumor was completely excised. Final pathology revealed it to be a mediastinal neurothekeoma...
June 2015: Asian Cardiovascular & Thoracic Annals
E Gjurčević, S Kužir, A Sfacteria, K Drašner, F Marino
This report describes a peripheral nerve sheath tumour in 8 European eels Anguilla anguilla L. from a fish farm located in Croatia. The newborn tissue appeared as smooth and soft skin nodules without pronounced colour change. Nodules were dome-shaped with a pale crater and were present on different body areas. In general, nodules were located as series of differently sized protrusions extending along the lateral line on both sides of the fish, as well as sensory canals on the head. Cut sections showed a homogeneous, pale white-grey texture...
September 30, 2014: Diseases of Aquatic Organisms
Andrew S Erwteman, Tessa Balach
Benign lesions comprise a majority of soft tissue tumors. It has been estimated that their incidence outnumbers that of malignant tumors by a factor of at least 100 [1]. While history and physical examination can start the diagnostic process, imaging including the use of magnetic resonance imaging can be more helpful. Biopsy of these tumors is sometimes necessary and can be performed in a number of ways, often in conjunction with definitive treatment. Specific diagnostic and treatment strategies for a number of the more commonly encountered benign soft tissue tumors including lipomas, pigmented villonodular synovitis and hemangiomas are reviewed...
2014: Cancer Treatment and Research
Jonelle M Petscavage-Thomas, Eric A Walker, Chika I Logie, Loren E Clarke, Dennis M Duryea, Mark D Murphey
Myxoid soft-tissue lesions are a heterogeneous group of benign and malignant mesenchymal tumors with an abundance of extracellular mucoid material. These lesions may mimic cysts on radiologic evaluation because of the high water content, and histopathologic features also overlap. Benign myxoid lesions include intramuscular myxoma, synovial cyst, bursa, ganglion, and benign peripheral nerve sheath tumor, including neurofibroma and schwannoma. Malignant entities include myxoid liposarcoma, myxoid leiomyosarcoma, myxoid chondrosarcoma, ossifying fibromyxoid tumor, and myxofibrosarcoma...
July 2014: Radiographics: a Review Publication of the Radiological Society of North America, Inc
Francesco Spadari, Gianpaolo Guzzi, Gian Paolo Bombeccari, Umberto Mariani, Andrea Gianatti, Diego Ruffoni, Dario Costantino
Nerve sheath myxoma (NSM) of the oral mucosa is a slow-growing, benign, often asymptomatic submucosal mass. We report on a case of classical NSM of the tongue, with diagnostic and therapeutic approach to the case. Many NSM arise within the endoneurium of a peripheral nerve. It is a rare condition with no apparent differences between sexes in its prevalence. It can occur at any age.
2014: Acta Dermatovenerologica Croatica: ADC
Tan Aik Kah, Ku Chui Yong, Faridah Hanom Annuar
We report a case of 10-year-old Indian girl with history of multiple superficial angiomyxoma, presented with three months history of painless right upper lid swelling. There were no visual dysfunctions. Previously, the patient had multiple superficial angiomyxoma (left pinna, left upper cheek, left upper limb, chest, right axilla, hard palate) and epidermal cyst (chin). The histopathological specimens were negative to S-100 protein antibody. Systemic review and family history was unremarkable. Excision biopsy and upper lid reconstruction were performed...
July 1, 2011: Clinics and Practice
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