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https://www.readbyqxmd.com/read/29330291/keap1-inhibits-metastatic-properties-of-nsclc-cells-by-stabilizing-architectures-of-f-actin-and-focal-adhesions
#1
Bo Wu, Shu Yang, Haimei Sun, Tingyi Sun, Fengqing Ji, Yurong Wang, Lie Xu, Deshan Zhou
Low expression of the tumor suppressor, Kelch-like ECH-associated protein 1 (KEAP1) in non-small cell lung cancer (NSCLC) often results in higher malignant biological behavior and poor prognosis; however, the underlying mechanism remains unclear. The present study demonstrates that overexpression of Keap1 significantly suppresses migration and invasion of three different lung cancer cells (A549, H460, and H1299). Highly-expressed Keap1, compared to the control, promotes formation of multiple stress fibers with larger mature focal adhesion complexes in the cytoplasm where only fine focal adhesions were observed in the membrane under control conditions...
January 12, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29321114/nebulized-ketamine-to-avoid-mechanical-ventilation-in-a-pediatric-patient-with-severe-asthma-exacerbation
#2
Abdelghafour Elkoundi, Aziza Bentalha, Alae El Koraichi, Salma Ech-Cherif El Kettani
Asthma is a major cause of morbidity and mortality despite advances in outpatient treatment. Sometimes, children fail to respond to standard treatment and can potentially require mechanical ventilation. We describe a case of a 26-month-old girl with a severe asthma exacerbation successfully managed by ketamine administration via nebulization route that permitted to avoid mechanical ventilation. Nebulized ketamine might be a reasonable option to avoid mechanical ventilation in children who fail to respond to standard treatment of severe asthma exacerbation...
January 6, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29306329/gene-expression-signature-regulated-by-the-keap1-nrf2-cul3-axis-is-associated-with-a-poor-prognosis-in-head-and-neck-squamous-cell-cancer
#3
Akhileshwar Namani, Md Matiur Rahaman, Ming Chen, Xiuwen Tang
BACKGROUND: NRF2 is the key regulator of oxidative stress in normal cells and aberrant expression of the NRF2 pathway due to genetic alterations in the KEAP1 (Kelch-like ECH-associated protein 1)-NRF2 (nuclear factor erythroid 2 like 2)-CUL3 (cullin 3) axis leads to tumorigenesis and drug resistance in many cancers including head and neck squamous cell cancer (HNSCC). The main goal of this study was to identify specific genes regulated by the KEAP1-NRF2-CUL3 axis in HNSCC patients, to assess the prognostic value of this gene signature in different cohorts, and to reveal potential biomarkers...
January 6, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29297655/the-emerging-role-of-gammacore-in-the-management-of-cluster-headache-expert-panel-recommendations
#4
Stephen D Silberstein, Anne H Calhoun, Christina Treppendahl, David W Dodick, Alan M Rapoport, Avinash Mamidi, Peter Vargas, Thomas H Ebert, Stewart J Tepper
A panel of 9 experts, including neurologists, other headache specialists, and medical and pharmacy directors, from 4 health plans (1 integrated delivery network and 3 plans with commercial, Medicare, and Medicaid lines of business), convened to discuss cluster headache (CH). Topics covered included the current treatment landscape, treatment challenges, economic impact of disease, and gaps in care for patients with CH. One major challenge in the management of CH is that it is underrecognized and frequently misdiagnosed, leading to delays in and suboptimal treatment for patients who suffer from this painful and disabling condition...
November 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/29297654/review-of-non-invasive-vagus-nerve-stimulation-gammacore-efficacy-safety-potential-impact-on-comorbidities-and-economic-burden-for-episodic-and-chronic-cluster-headache
#5
Mkaya Mwamburi, Eric J Liebler, Andrew T Tenaglia
The FDA has cleared gammaCore (non-invasive vagus nerve stimulator [nVNS]) for the treatment of episodic cluster headache (eCH). With the exception of subcutaneous sumatriptan, all other treatments are used off label and have many limitations. The FDA approval process for devices differs from that of drugs. We performed a review of the literature to evaluate new evidence on various aspects of gammaCore treatment and impact. The ACute Treatment of Cluster Headache Studies (ACT1 and ACT2), both double-blind sham-controlled randomized trials, did not meet the primary endpoints of the trials but each demonstrated significant superiority of gammaCore among patients with eCH...
November 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/29273684/sp600125-suppresses-keap1-expression-and-results-in-nrf2-mediated-prevention-of-diabetic-nephropathy
#6
Huan Zhang, Xiuxia Liu, Shanshan Zhou, Ye Jia, Ying Li, Yuguo Song, Junnan Wang, Hao Wu
c-Jun N-terminal kinase (JNK) contributes to the pathogenesis of diabetic nephropathy (DN). The JNK inhibitor SP600125 was reported to ameliorate DN. However, the mechanism remained unclear. We previously reported that SP600125 activated nuclear factor erythroid 2-related factor 2 (NRF2), a governor of the cellular antioxidant defense system, in the aortas of the diabetic mice. Given the critical role of NRF2 in preventing DN, the present study aimed to test whether or not NRF2 is required for SP600125's protection against DN...
December 22, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29248776/spinal-epidural-cavernous-hemangioma-a-clinical-series-of-seven-patients
#7
Chuanping Gao, Wenjian Xu, Ji Qing Lian, Duan Feng, Jiu Fa Cui, Hua Liu
OBJECTIVE: The aim of this study was to investigate the imaging characteristics of spinal epidural cavernous hemangiomas (ECH) and improve the understanding of this rare disease. METHODS: This retrospective study included seven cases of ECH, confirmed with surgical pathology and imaging. All patients underwent computed tomographic and conventional magnetic resonance imaging. One of the seven patients underwent diffusion-weighted imaging. RESULTS: The ECH originated from vertebrae with coarsened trabeculae in five patients...
December 14, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29248720/ckip-1-affects-the-polyubiquitination-of-nrf2-and-keap1-via-mediating-smurf1-to-resist-hg-induced-renal-fibrosis-in-gmcs-and-diabetic-mice-kidneys
#8
Wenyan Gong, Zhiquan Chen, Yezi Zou, Lei Zhang, Junying Huang, Peiqing Liu, Heqing Huang
Our previous study indicated that Casein kinase 2 interacting protein-1 (CKIP-1) could promote the activation of the nuclear factor E2-related factor 2 (Nrf2)/ antioxidant response element (ARE) pathway, playing a significant role in inhibiting the fibrosis of diabetic nephropathy (DN). However, the underlying mechanism is still unknown. Here, we investigated whether CKIP-1 affects the polyubiquitination of Nrf2 and its cytosolic inhibitor kelch like ECH-associated protein 1 (Keap1) via mediating Smad ubiquitylation regulatory factor-1 (Smurf1) to promote the activation of the Nrf2/ARE signaling and resist high glucose (HG)-induced renal fibrosis in glomerular mesangial cells (GMCs) and diabetic mice kidneys...
February 1, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29243436/-effect-of-neoflavonoid-latifolin-isolated-from-dalbergia-odorifera-on-acute-myocardial-ischemia-in-rats-and-its-mechanism-of-nrf2-signaling-pathway
#9
Xue-Liang Li, Lan-Ying Chen, Zi-Yi Guan, Yao Luo, Ya-Ru Cui, Rong-Hua Liu, Feng Shao, Ding-Qing Wang
The present study was designed to evaluate the cardioprotective effect of latifolin on pituitrin(Pit) or isoproterenol(ISO)-induced myocardial injury in rats, and further investigate its underlying mechanisms. Rats were administrated sublingually with pituitrin or subcutaneously with isoproterenol to induce acute myocardial ischemia in rats, and lead II electrocardiograph was recorded. In rats with isoproterenol, ELISA assay or colorimetric method was used to detect the content or activity of myocardial injury markers in serum, and the SOD activity and MDA content in myocardium were detected by colorimetric assay; histopathological examination was conducted by HE staining; the frozen section of myocardial tissues was used for DCFH-DA fluorescent staining to detect the content of ROS in myocardium; Western blot was used to detect the protein expression levels of Nrf2, Keap1, HO-1 and NQO1 in myocardium...
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29231763/non-invasive-vagus-nerve-stimulation-for-the-acute-treatment-of-episodic-and-chronic-cluster-headache-a-randomized-double-blind-sham-controlled-act2-study
#10
Peter J Goadsby, Ilse F de Coo, Nicholas Silver, Alok Tyagi, Fayyaz Ahmed, Charly Gaul, Rigmor H Jensen, Hans-Christoph Diener, Kasia Solbach, Andreas Straube, Eric Liebler, Juana Ca Marin, Michel D Ferrari
Background Clinical observations and results from recent studies support the use of non-invasive vagus nerve stimulation (nVNS) for treating cluster headache (CH) attacks. This study compared nVNS with a sham device for acute treatment in patients with episodic or chronic CH (eCH, cCH). Methods After completing a 1-week run-in period, subjects were randomly assigned (1:1) to receive nVNS or sham therapy during a 2-week double-blind period. The primary efficacy endpoint was the proportion of all treated attacks that achieved pain-free status within 15 minutes after treatment initiation, without rescue treatment...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29222028/sodium-butyrate-enhanced-physical-barrier-function-referring-to-nrf2-jnk-and-mlck-signaling-pathways-in-the-intestine-of-young-grass-carp-ctenopharyngodon-idella
#11
Pei Wu, Li Tian, Xiao-Qiu Zhou, Wei-Dan Jiang, Yang Liu, Jun Jiang, Fei Xie, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Juan Yang, Yong-An Zhang, He-Qun Shi, Lin Feng
This study evaluated the effect of dietary sodium butyrate (SB) supplementation on the intestinal physical barrier function of young grass carp (Ctenopharyngodon idella). The fish were fed one powdery sodium butyrate (PSB) diet (1000.0 mg kg-1 diet) and five graded levels of microencapsulated sodium butyrate (MSB) diets: 0.0 (control), 500.0, 1000.0, 1500.0 and 2000.0 mg kg-1 diet for 60 days. Subsequently, a challenge test was conducted by injection of Aeromonas hydrophila to explore the effect of SB supplementation on intestinal physical barrier function and the potential mechanisms in fish...
December 5, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29213348/probucol-protects-rats-from-cardiac-dysfunction-induced-by-oxidative-stress-following-cardiopulmonary-resuscitation
#12
Xu Xiao, Huiyuan Hou, Victor Lin, Daisy Ho, Kyle Tran, Briana Che, Adam May, Jiancheng Zhang, Zhigang Lu, Zhongping Lu, Peter X Shaw
Objective: To investigate the protective effect of probucol on induced cardiac arrest (CA) rats and possible mechanisms. Methods: Sprague Dawley rats were orally administrated with probucol at different dosage or vehicle for 5 days and subjected to a CA model by electrical stimulation, followed by cardiopulmonary resuscitation (CPR). The return of spontaneous circulation (ROSC) rate, antioxidant enzyme activities, and lipid oxidation markers were measured in serum and myocardium...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29212307/dysregulation-of-nrf2-in-cancer-from-molecular-mechanisms-to-therapeutic-opportunities
#13
REVIEW
Byung-Jin Jung, Hwan-Sic Yoo, Sooyoung Shin, Young-Joon Park, Sang-Min Jeon
Nuclear factor E2-related factor 2 (NRF2) plays an important role in redox metabolism and antioxidant defense. Under normal conditions, NRF2 proteins are maintained at very low levels because of their ubiquitination and proteasomal degradation via binding to the kelch‑like ECH associated protein 1 (KEAP1)-E3 ubiquitin ligase complex. However, oxidative and/or electrophilic stresses disrupt the KEAP1-NRF2 interaction, which leads to the accumulation and transactivation of NRF2. During recent decades, a growing body of evidence suggests that NRF2 is frequently activated in many types of cancer by multiple mechanisms, including the genetic mutations in the KEAP1-NRF2 pathway...
December 7, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/29210072/chemical-hypoxia-induced-integrated-stress-response-activation-in-oligodendrocytes-is-mediated-by-the-transcription-factor-nuclear-factor-erythroid-derived-2-like-2-nrf2
#14
Nico Teske, Annette Liessem, Felix Fischbach, Tim Clarner, C Beyer, Christoph Wruck, Athanassios Fragoulis, Simone C Tauber, Marion Victor, Markus Kipp
The extent of remyelination in multiple sclerosis (MS) lesions is often incomplete. Injury to oligodendrocyte progenitor cells can be a contributing factor for such incomplete remyelination. The precise mechanisms underlying insufficient repair remain to be defined, but oxidative stress appears to be involved. Here, we used immortalized oligodendrocyte cell lines as model systems to investigate a causal relation of oxidative stress and endoplasmic reticulum stress signaling cascades. OLN93 and OliNeu cells were subjected to chemical hypoxia by blocking the respiratory chain at various levels...
December 6, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29209447/nrf2-a-potential-therapeutic-target-against-oxidative-stress-in-corneal-diseases
#15
REVIEW
Xiu-Fen Liu, Dan-Dan Zhou, Tian Xie, Tayyab Hamid Malik, Cheng-Bo Lu, Hai-Jun Li, Fan Wang, Chang Shu, Cong Liu, Cheng-Wei Lu, Ji-Long Hao
Corneal diseases are one of the major causes of blindness worldwide. Conservative medical agents, which may prevent sight-threatening corneal disease progression, are urgently desired. Numerous evidences have revealed the involvement of oxidative stress in various corneal diseases, such as corneal wound healing and Fuchs endothelial corneal dystrophy (FECD). Nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/Kelch-like erythroid-cell-derived protein with CNC homology- (ECH-) associated protein 1 (Keap1)/antioxidant response element (ARE) signaling is well known as one of the main antioxidative defense systems...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29196031/effects-of-various-feeding-patterns-of-bacillus-coagulans-on-growth-performance-antioxidant-response-and-nrf2-keap-1-signaling-pathway-in-juvenile-gibel-carp-carassius-auratus-gibelio
#16
Yebing Yu, Changhai Wang, Aimin Wang, Wenping Yang, Fu Lv, Fei Liu, Bo Liu, Cunxin Sun
The present study was conducted to evaluate the effects of various Bacillus coagulans feeding patterns on growth, antioxidant parameter and Nrf2 pathway in juvenile gibel carp. The similar size of gibel carp (initial weight: 14.33 ± 0.15 g) were subjected to three levels of B. coagulans supplementation (0, 500, and 1000 mg/kg) and two feeding modes (supplementing B. coagulans continuously or for two days of B. coagulans after 5 days of a basal diet) according to a 3 × 2 factorial design. The fish that were continuously fed 500 mg/kg B...
November 28, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29193364/the-influence-and-mechanism-of-ligustilide-senkyunolide-i-and-senkyunolide-a-on-echinacoside-transport-through-mdck-mdr1-cells-as-blood-brain-barrier-in-vitro-model
#17
Qin Zheng, Yu Tang, Peng-Yi Hu, Dan Liu, Delin Zhang, Pengfei Yue, Yuanyuan Guo, Ming Yang
Efficient transcytosis across the blood-brain-barrier is an important strategy for accessing drug targets within the central nervous system. Ligusticum chuanxiong Hort. was used as a messenger drug to increase the distribution of drugs in brain tissue in Traditional Chinese Medicine. The present study investigates the transport of echinacoside (ECH) through MDCK-MDR1 cell and the effects of ligustilide (LIG), senkyunolide A (SENA) and senkyunolide I (SENI) in chuanxiong on its transport. The results indicated that the absorption of ECH was relatively poor in MDCK-MDR1cells, and was concentration dependent and not saturable...
November 29, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29193259/lipopolysaccharide-levels-adherent-to-pm2-5-play-an-important-role-in-particulate-matter-induced-immunosuppressive-effects-in-mouse-splenocytes
#18
Cuiying He, Yuan Song, Takamichi Ichinose, Miao He, Kentaro Morita, Duo Wang, Tamotsu Kanazawa, Yasuhiro Yoshida
Epidemiological studies show that exposure to ambient particulate matter (PM) is associated with serious adverse health effects, including, but not limited to, those on the respiratory system. In the present study, we investigated the splenic response in mice administered PM of ≤ 2.5 μ m diameter (PM2.5). Male BALB/c mice (7 or 8 weeks old) were intratracheally administered PM2.5 (0.1 mg) four times, at 2 week intervals, and dissected 24 h after the final administration. The effect of six types of PM2...
November 29, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29185166/echinacoside-a-phenylethanoid-glycoside-from-cistanche-deserticola-extends-lifespan-of-caenorhabditis-elegans-and-protects-from-a%C3%AE-induced-toxicity
#19
Wei Chen, Hong-Ru Lin, Cong-Min Wei, Xiao-Hua Luo, Meng-Lu Sun, Zhen-Zhou Yang, Xin-Yan Chen, Hong-Bing Wang
Cistanche deserticola has been found to exert protection against aging and age-related diseases, but mechanisms underlying its longevity effects remain largely unclear. Here, the multicellular model organism Caenorhabditis elegans was employed to identify lifespan extending and protective effects against β-amyloid (Aβ) induced toxicity by echinacoside (ECH), a phenylethanoid glycoside isolated from C. deserticola. Our results showed that ECH extends the mean lifespan of worms and increases their survival under oxidative stress...
November 28, 2017: Biogerontology
https://www.readbyqxmd.com/read/29177481/cdyl1-fosters-double-strand-break-induced-transcription-silencing-and-promotes-homology-directed-repair
#20
Enas R Abu-Zhayia, Samah W Awwad, Bella Ben-Oz, Hanan Khoury-Haddad, Nabieh Ayoub
Cells have evolved DNA damage response (DDR) to repair DNA lesions and thus preserving genomic stability and impeding carcinogenesis. DNA damage induction is accompanied by transient transcription repression. Here, we describe a previously unrecognized role of chromodomain Y-like (CDYL1) protein in fortifying double-strand break (DSB)-induced transcription repression and repair. We showed that CDYL1 is rapidly recruited to damaged euchromatic regions in a poly [ADP-ribose] polymerase 1 (PARP1)-dependent, but ataxia telangiectasia mutated (ATM)-independent, manner...
November 21, 2017: Journal of Molecular Cell Biology
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