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https://www.readbyqxmd.com/read/28722304/nrf2-as-a-target-for-prevention-of-age-related-and-diabetic-cataracts-by-against-oxidative-stress
#1
REVIEW
Xiu-Fen Liu, Ji-Long Hao, Tian Xie, Tayyab Hamid Malik, Cheng-Bo Lu, Cong Liu, Chang Shu, Cheng-Wei Lu, Dan-Dan Zhou
Cataract is one of the most important causes of blindness worldwide, with age-related cataract being the most common one. Agents preventing cataract formation are urgently required. Substantial evidences point out aggravated oxidative stress as a vital factor for cataract formation. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/Kelch-like erythroid-cell-derived protein with CNC homology (ECH)-associated protein 1 (Keap1) system is considered as one of the main cellular defense mechanisms against oxidative stresses...
July 19, 2017: Aging Cell
https://www.readbyqxmd.com/read/28698127/dietary-protein-levels-regulated-antibacterial-activity-inflammatory-response-and-structural-integrity-in-the-head-kidney-spleen-and-skin-of-grass-carp-ctenopharyngodon-idella-after-challenged-with-aeromonas-hydrophila
#2
Wei-Dan Jiang, Jing Xu, Xiao-Qiu Zhou, Pei Wu, Yang Liu, Jun Jiang, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Yong-An Zhang, Lin Feng
This study investigated the effects of dietary protein levels on disease resistance, immune function and structural integrity in the head kidney, spleen and skin of grass carp (Ctenopharyngodon idella). A total of 540 grass carp (264.11 ± 0.76 g) were fed six diets containing graded levels of protein (143.1, 176.7, 217.2, 257.5, 292.2 and 322.8 g digestible protein kg(-1) diet) for 8 weeks. After the growth trial, fish were challenged with Aeromonas hydrophila for 14 days. The results indicated that optimal levels of dietary protein: (1) (1) increased the lysozyme (LA) and acid phosphatase (ACP) activities and the complement 3 (C3) and C4 contents, up-regulated antimicrobial peptides, anti-inflammatory cytokines, inhibitor of κBα, target of rapamycin and ribosomal protein S6 kinases 1 mRNA levels, whereas down-regulated pro-inflammatory cytokines, nuclear factor kappa B (NF-κB) P65, IKKβ, IKKγ, eIF4E-binding proteins (4E-BP) 1 and 4E-BP2 mRNA levels in the head kidney, spleen and skin of grass carp (P < 0...
July 8, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28694839/gene-expression-profiling-of-whole-blood-cells-supports-a-more-efficient-mitochondrial-respiration-in-hypoxia-challenged-gilthead-sea-bream-sparus-aurata
#3
Juan Antonio Martos-Sitcha, Azucena Bermejo-Nogales, Josep Alvar Calduch-Giner, Jaume Pérez-Sánchez
BACKGROUND: Acclimation to abiotic challenges, including decreases in O2 availability, requires physiological and anatomical phenotyping to accommodate the organism to the environmental conditions. The retention of a nucleus and functional mitochondria in mature fish red blood cells makes blood a promising tissue to analyse the transcriptome and metabolic responses of hypoxia-challenged fish in an integrative and non-invasive manner. METHODS: Juvenile gilthead sea bream (Sparus aurata) were reared at 20-21 °C under normoxic conditions (> 85% O2 saturation) followed by exposure to a gradual decrease in water O2 concentration to 3...
2017: Frontiers in Zoology
https://www.readbyqxmd.com/read/28690762/sestrin2-as-a-novel-biomarker-and-therapeutic-target-for-various-diseases
#4
REVIEW
Mazhar Pasha, Ali H Eid, Assaad A Eid, Yves Gorin, Shankar Munusamy
Sestrin2 (SESN2), a highly conserved stress-inducible metabolic protein, is known to repress reactive oxygen species (ROS) and provide cytoprotection against various noxious stimuli including genotoxic and oxidative stress, endoplasmic reticulum (ER) stress, and hypoxia. Studies demonstrate that the upregulation of Sestrin2 under conditions of oxidative stress augments autophagy-directed degradation of Kelch-like ECH-associated protein 1 (Keap1), which targets and breaks down nuclear erythroid-related factor 2 (Nrf2), a key regulator of various antioxidant genes...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28684421/pharmacological-stimulation-of-nuclear-factor-erythroid-derived-2-like-2-translation-activates-antioxidant-responses
#5
Oscar Perez-Leal, Carlos Alberto Barrero, Salim Merali
Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the master regulator of the antioxidant response, and its function is tightly regulated at the transcriptional, translational, and post- translational levels. It is well known that Nrf2 is regulated at the protein level by proteasomal degradation via Kelch-like ECH-associated protein 1 (Keap1), but how Nrf2 is regulated at the translational level is less clear. Here, we show that pharmacological stimulation increases Nrf2 levels by overcoming basal translational repression...
July 6, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28679254/effects-of-the-interface-roughness-in-metal-adhesive-metal-structure-on-the-propagation-of-shear-horizontal-waves
#6
Mounsif Ech Cherif El Kettani, Damien Leduc, Catherine Potel, Michel Bruneau, Ludovic Foze, Mihai Predoi
The influence of the interface roughness in a three-layer metal-adhesive-metal structure on the propagation of shear horizontal waves and more particularly on the transmission coefficient versus the frequency is studied in the particular case of a periodic grating of triangular grooves. For given phonon frequencies, the interaction of an incident shear horizontal mode with the periodical grating gives rise to a retro-converted mode. A numerical finite element simulation permits us to predict the existence of the phonon mode in the three-layer structure and to obtain the evolution of the transmission coefficient around the phonon frequency...
June 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28669677/detection-of-blavim-7-in-an-extensively-drug-resistant-pseudomonas-aeruginosa-isolate-belonging-to-st1284-in-brazil
#7
Suelen Balero de Paula, Rodrigo Cayô, Ana Paula Streling, Carolina Silva Nodari, Adriana Pereira Matos, Marcia Regina Eches Perugini, Ana Cristina Gales, Floristher Elaine Carrara-Marroni, Sueli F Yamada-Ogatta
We described for the first time an extensively drug-resistant Pseudomonas aeruginosa isolate belonging to ST1284 carrying a plasmid-mediated blaVIM-7 in Brazil. The blaVIM-7 was harbored by an integron that also carried aacA4 and blaOXA-46. Multiple virulence factors were also detected.
June 17, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28660797/evaluating-cultural-competence-of-pediatric-oncology-nurses-at-a-teaching-hospital-a-pilot-study
#8
Ijeoma Julie Eche, Teri Aronowitz
This cross-sectional descriptive study evaluated registered nurses' self-ratings of cultural competence on the hematology/oncology unit at a large Northeastern urban children's hospital. The Inventory for Assessing the Process of Cultural Competence among Healthcare Professionals was used to measure 5 constructs of cultural competence. The study findings show that there were significant correlations between the knowledge and skill subscales (ρ = .57, P < .001) and the knowledge and desire subscales (ρ = ...
June 1, 2017: Journal of Pediatric Oncology Nursing: Official Journal of the Association of Pediatric Oncology Nurses
https://www.readbyqxmd.com/read/28659629/engineering-biodegradable-and-biocompatible-bio-ionic-liquid-conjugated-hydrogels-with-tunable-conductivity-and-mechanical-properties
#9
Iman Noshadi, Brian W Walker, Roberto Portillo-Lara, Ehsan Shirzaei Sani, Nayara Gomes, Mohammad Reza Aziziyan, Nasim Annabi
Conventional methods to engineer electroconductive hydrogels (ECHs) through the incorporation of conductive nanomaterials and polymers exhibit major technical limitations. These are mainly associated with the cytotoxicity, as well as poor solubility, processability, and biodegradability of their components. Here, we describe the engineering of a new class of ECHs through the functionalization of non-conductive polymers with a conductive choline-based bio-ionic liquid (Bio-IL). Bio-IL conjugated hydrogels exhibited a wide range of highly tunable physical properties, remarkable in vitro and in vivo biocompatibility, and high electrical conductivity without the need for additional conductive components...
June 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28656391/antioxidant-activity-of-whole-grain-highland-hull-less-barley-and-its-effect-on-liver-protein-expression-profiles-in-rats-fed-with-high-fat-diets
#10
Xuejuan Xia, Guannan Li, Yuxiao Xing, Yongbo Ding, Tingyuan Ren, Jianquan Kan
PURPOSE: Whole grain exhibits potential for regulating lipid levels, possibly because of its antioxidant activity. This study aims to investigate the antioxidant activity of whole grain highland hull-less barley (WHLB) and its effect on liver protein expression profiles in rats fed with high-fat diets. METHODS: Antioxidant activity of WHLB was investigated in vitro by analyzing phenolic and pentosan contents and oxygen radical absorbance capacity (ORAC). Proteins involved in lipid regulation were investigated in vivo by analyzing liver protein expression profiles in Sprague-Dawley rats fed with high-fat diet (HFD) with or without WHLB...
June 27, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28645578/the-electrophilic-character-of-quinones-is-essential-for-the-suppression-of-bach1
#11
Chuanyang Su, Zixuan Liu, Yawen Wang, Yuxin Wang, Erqun Song, Yang Song
The activation of nuclear factor erythroid 2-related factor 2 (Nrf2) is the most important cellular defense mechanisms against oxidative attack. BTB and CNC homology-1 (Bach1), like Kelch-like ECH-associated protein 1 (Keap1), is one of a negative regulator of Nrf2 that control antioxidant response elements (ARE)-dependent gene expressions. In the current study, we found that quinones show greater capacity than hydroquinones in nuclear Bach1 export, as well as ubiquitin-dependent Bach1 degradation in our experimental time frame...
June 20, 2017: Toxicology
https://www.readbyqxmd.com/read/28642811/actinidia-chinensis-planch-improves-the-indices-of-antioxidant-and-anti-inflammation-status-of-type-2-diabetes-mellitus-by-activating-keap1-and-nrf2-via-the-upregulation-of-microrna-424
#12
Longfeng Sun, Xiaofei Li, Gang Li, Bing Dai, Wei Tan
The fruit juice of Actinidia chinensis Planch. has antioxidant and anti-inflammation properties on patients with type 2 diabetes mellitus (T2DM), but the molecular mechanism was unclear. The patients took the juice and the serum level of antioxidant miR-424, Kelch-like ECH-associated protein 1 (Keap1), erythroid-derived 2-like 2 (Nrf2), and biochemical indices were measured. The juice increased the levels of serum microRNA-424, Keap1, and Nrf2 and reduced the levels of interleukin-1 (IL-1) beta and IL-6 in T2DM patients...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28638054/drug-repositioning-screening-for-keap1-nrf2-binding-inhibitors-using-fluorescence-correlation-spectroscopy
#13
Yuki Yoshizaki, Takayasu Mori, Mari Ishigami-Yuasa, Eriko Kikuchi, Daiei Takahashi, Moko Zeniya, Naohiro Nomura, Yutaro Mori, Yuya Araki, Fumiaki Ando, Shintaro Mandai, Yuri Kasagi, Yohei Arai, Emi Sasaki, Sayaka Yoshida, Hiroyuki Kagechika, Tatemitsu Rai, Shinichi Uchida, Eisei Sohara
The Kelch-like ECH-associating protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) signaling pathway is the major regulator of cytoprotective responses to oxidative and electrophilic stress. The Cul3/Keap1 E3 ubiquitin ligase complex interacts with Nrf2, leading to Nrf2 ubiquitination and degradation. In this study, we focused on the disruption of the Keap1-Nrf2 interaction to upregulate Nrf2 expression and the transcription of ARE-controlled cytoprotective oxidative stress response enzymes, such as HO-1...
June 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28625872/decreased-enteritis-resistance-ability-by-dietary-low-or-excess-levels-of%C3%A2-lipids-through-impairing-the-intestinal-physical-and-immune-barriers-function-of-young-grass-carp-ctenopharyngodon-idella
#14
Lin Feng, Pei-Jun Ni, Wei-Dan Jiang, Pei Wu, Yang Liu, Jun Jiang, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Yong-An Zhang, Xu Tang, He-Qun Shi, Xiao-Qiu Zhou
The current study explores the hypothesis that low or excess levels of lipids decrease the enteritis resistance ability through impairing the intestinal physical and immune barrier function of young grass carp (Ctenopharyngodon idella). A total of 540 young grass carp with an average initial weight of 261.41 ± 0.53 g were fed diets containing six graded levels of lipids at 5.9, 21.4, 36.0, 50.2, 66.6 and 80.1 g/kg for 8 weeks. After that, a challenge trial was conducted by injection of Aeromonas hydrophila over 2 weeks...
August 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28621229/the-role-of-nrf2-keap1-axis-in-colorectal-cancer-progression-and-chemoresistance
#15
REVIEW
Mohammad Reza Sadeghi, Farhad Jeddi, Narges Soozangar, Mohammad Hossein Somi, Nasser Samadi
Colorectal cancer is the third common cancer after lung and genital cancers worldwide with more than 1.2 million new cases diagnosed annually. Although extensive progress has been made in the treatment of colorectal cancer, finding novel targets for early diagnosis and effective treatment of these patients is an urgent need. Nuclear factor-erythroid 2-kelch-like ECH-associated protein 1 signaling pathway plays a key role in protecting cells from the damage of intracellular oxidative stress and extracellular oxidizing agents...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28619361/%C3%AE-lipoic-acid-ameliorates-n-3-highly-unsaturated-fatty-acids-induced-lipid-peroxidation-via-regulating-antioxidant-defenses-in-grass-carp-ctenopharyngodon-idellus
#16
Xiao-Chen Shi, Ai Jin, Jian Sun, Zhou Yang, Jing-Jing Tian, Hong Ji, Hai-Bo Yu, Yang Li, Ji-Shu Zhou, Zhen-Yu Du, Li-Qiao Chen
This study evaluated the protective effect of α-lipoic acid (LA) on n-3 highly unsaturated fatty acids (HUFAs)-induced lipid peroxidation in grass carp. The result indicated that diets with n-3 HUFAs increased the production of malondialdehyde (MDA) (P < 0.05), thereby inducing lipid peroxidation in liver and muscle of grass carp. Meanwhile, compared with control group, the hepatosomatic index (HSI) and kidney index (KI) of grass carp were markedly increased in n-3 HUFAs-only group. However, diets with LA remarkably inhibited the n-3 HUFAs-induced increase of HSI, KI, and MDA level in serum, liver and muscle (P < 0...
August 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28615062/metabolic-and-transcriptional-elucidation-of-the-carotenoid-biosynthesis-pathway-in-peel-and-flesh-tissue-of-loquat-fruit-during-on-tree-development
#17
Margarita Hadjipieri, Egli C Georgiadou, Alicia Marin, Huertas M Diaz-Mula, Vlasios Goulas, Vasileios Fotopoulos, Francisco A Tomás-Barberán, George A Manganaris
BACKGROUND: Carotenoids are the main colouring substances found in orange-fleshed loquat fruits. The aim of this study was to unravel the carotenoid biosynthetic pathway of loquat fruit (cv. 'Obusa') in peel and flesh tissue during distinct on-tree developmental stages through a targeted analytical and molecular approach. RESULTS: Substantial changes regarding colour parameters, both between peel and flesh and among the different developmental stages, were monitored, concomitant with a significant increment in carotenoid content...
June 14, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28610850/dietary-myo-inositol-deficiency-decreased-the-growth-performances-and-impaired-intestinal-physical-barrier-function-partly-relating-to-nrf2-jnk-e2f4-and-mlck-signaling-in-young-grass-carp-ctenopharyngodon-idella
#18
Shuang-An Li, Wei-Dan Jiang, Lin Feng, Yang Liu, Pei Wu, Jun Jiang, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Yong-An Zhang, Xu Tang, He-Qun Shi, Xiao-Qiu Zhou
In this study, we investigated the effects of dietary myo-inositol on the growth and intestinal physical barrier functions of young grass carp (Ctenopharyngodon idella). A total of 540 young grass carp (221.83 ± 0.84 g) were fed six diets containing graded levels of myo-inositol (27.0, 137.9, 286.8, 438.6, 587.7 and 737.3 mg/kg) for 10 weeks. After the growth trial, fish were challenged with Aeromonas hydrophila for 14 days. The results indicated that compared with optimal myo-inositol levels, myo-inositol deficiency (27...
August 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28585211/non-alcoholic-fatty-liver-disease
#19
Atilla Engin
Non-alcoholic fatty liver disease (NAFLD) is in parallel with the obesity epidemic and it is the most common cause of liver diseases. The development of hepatic steatosis in majority of patients is linked to dietary fat ingestion. NAFLD is characterized by excess accumulation of triglyceride in the hepatocyte due to both increased inflow of free fatty acids and de novo hepatic lipogenesis. Insulin resistance with the deficiency of insulin receptor substrate-2 (IRS-2)-associated phosphatidylinositol 3-kinase (PI3K) activity causes an increase in intracellular fatty acid-derived metabolites such as diacylglycerol, fatty acyl CoA or ceramides...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28583601/concentration-dependent-antioxidative-and-apoptotic-effects-of-sulforaphane-on-bovine-granulosa-cells-in%C3%A2-vitro
#20
Md Mahmodul Hasan Sohel, Yusuf Konca, Bilal Akyuz, Korhan Arslan, Serpil Sariozkan, Mehmet Ulas Cinar
Sulforaphane (SFN) has received a great deal of research attention because of its ability to induce the production of a battery of antioxidant enzymes in certain concentrations through the activation of the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signaling pathway, which may effectively neutralize reactive oxygen species (ROS) induced oxidative stress. This study was conducted to investigate the potential of different concentrations of SFN in inducing antioxidative and apoptotic effects in granulosa cells (GCs)...
July 15, 2017: Theriogenology
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