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https://www.readbyqxmd.com/read/29793178/nrf2-p-glycoprotein-axis-is-associated-with-clinicopathological-characteristics-in-colorectal-cancer
#1
Mohammad Reza Sadeghi, Farhad Jeddi, Narges Soozangar, Mohammad Hossein Somi, Masoud Shirmohamadi, Vahid Khaze, Nasser Samadi
Colorectal cancer (CRC) is the fourth leading cause of cancer-related death worldwide. Activation of ABCB1 gene and its main product, P-glycoprotein, is the common reason for chemoresistance. The nuclear factor-erythroid 2-related factor2 (Nrf2) is directly regulated by Kelch like ECH-associated protein1 (Keap1). In addition, Nrf2 is a key transcriptional factor that regulates efflux transporters, including P-gp. The aim of this study was to investigate the expression levels of Nrf2, Keap1 and ABCB1 in the biopsy samples and their association with clinicopathological features in CRC patients...
May 21, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29792945/cross-linking-by-epichlorohydrin-and-diepoxybutane-correlates-with-cytotoxicity-and-leads-to-apoptosis-in-human-leukemia-hl-60-cells
#2
Phuong M Le, Vanesa L Silvestri, Samuel C Redstone, Jordanne B Dunn, Julie T Millard
The bifunctional alkylating agents epichlorohydrin (ECH) and diepoxybutane (DEB) have been linked to increased cancer risks in industrial workers. These compounds react with DNA and proteins, leading to genotoxic effects. We used the comet assay to monitor formation of cross-links in HL-60 cells treated with ECH, DEB, and the structurally related anti-cancer drug mechlorethamine (HN2). We report a time- and dose-dependent cytotoxicity that correlated with cross-linking activity, following the order HN2 > DEB > ECH...
May 21, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29789801/exercise-prevents-diaphragm-wasting-induced-by-cigarette-smoke-through-modulation-of-antioxidant-genes-and-metalloproteinases
#3
Gracielle Vieira Ramos, Alessandra Choqueta de Toledo-Arruda, Clara Maria Pinheiro-Dardis, Camila Liyoko Suehiro, Thiago Luiz de Russo, Rodolfo Paula Vieira, Milton Arruda Martins, Tania Fátima Salvini, João Luiz Quagliotti Durigan
Background: The present study aimed to analyze the effects of physical training on an antioxidant canonical pathway and metalloproteinases activity in diaphragm muscle in a model of cigarette smoke-induced chronic obstructive pulmonary disease (COPD). Methods: Male mice were randomized into control, smoke, exercise, and exercise + smoke groups, which were maintained in trial period of 24 weeks. Gene expression of kelch-like ECH-associated protein 1; nuclear factor erythroid-2 like 2; and heme-oxygenase1 by polymerase chain reaction was performed...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29787640/elevated-levels-of-8-ohdg-and-park7-dj-1-in-peri-implantitis-mucosa
#4
Gökhan Kasnak, Erhan Firatli, Eija Könönen, Vakur Olgac, Fares Zeidán-Chuliá, Ulvi Kahraman Gursoy
BACKGROUND: Reactive oxygen species contribute to periodontal tissue homeostasis under control of anti-oxidative responses. Disruption in this balance induces severe inflammation and extended tissue degradation. PURPOSE: Aim of this study was to identify the expression levels of nuclear factor, erythroid 2 like 2 (NFE2L2/NRF2), Parkinsonism associated deglycase (PARK7/DJ-1), kelch-like ECH associated protein 1 (KEAP1), and 8-hydroxy-deoxyguanosine (8-OHdG) in peri-implant mucosal tissues affected by peri-implantitis, and to compare the levels to those of periodontally diseased and healthy tissue samples...
May 22, 2018: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/29783690/echinacoside-an-inestimable-natural-product-in-treatment-of-neurological-and-other-disorders
#5
REVIEW
Jingjing Liu, Lingling Yang, Yanhong Dong, Bo Zhang, Xueqin Ma
Echinacoside (ECH), a natural phenylethanoid glycoside, was first isolated from Echinacea angustifolia DC. (Compositae) sixty years ago. It was found to possess numerous pharmacologically beneficial activities for human health, especially the neuroprotective and cardiovascular effects. Although ECH showed promising potential for treatment of Parkinson's and Alzheimer's diseases, some important issues arose. These included the identification of active metabolites as having poor bioavailability in prototype form, the definite molecular signal pathways or targets of ECH with the above effects, and limited reliable clinical trials...
May 18, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29775904/biosynthesis-of-chiral-epichlorohydrin-using-an-immobilized-halohydrin-dehalogenase-in-aqueous-and-non-aqueous-phase
#6
Xiao-Jian Zhang, Ping-Xiu Shi, Han-Zhong Deng, Xin-Xin Wang, Zhi-Qiang Liu, Yu-Guo Zheng
Asymmetric synthesis of chiral epichlorohydrin (ECH) from 1,3-dichloro-2-propanol (1,3-DCP) using halohydrin dehalogenase (HHDH) is of great value due to the 100% theoretical yield and high enantioselectivity. In this study, HheC (P175S/W249P) was immobilized on an A502Ps resin and used for the preparation of (S)-ECH. In aqueous system, the immobilized HheC catalyzed the biosynthesis of (S)-ECH with 83.78% yield and 92.53% enantiomeric excess (ee) at 1,3-DCP concentration of 20 mM. The non-aqueous system was further developed using water saturated ethyl acetate as solvent and reaction phase...
May 8, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29773386/electroconductive-3d-polymeric-network-production-by-using-polyaniline-chitosan-based-hydrogel
#7
Celil Ulutürk, Neslihan Alemdar
Herein, polyaniline/chitosan(PANI/CTS)-based electroconductive hydrogel was produced by photocrosslinked network in which CTS was used as a main component. Firstly, glycidyl methacrylate (GMA) was grafted on the CTS backbone to form CTS-g-GMA. Then, a three-dimensional polymeric network consisting of CTS-g-GMA and poly(ethylene glycol)diacrylate (PEGDA) was obtained by using photocrosslinking technique. At last, aniline monomer solution prepared by utilizing three different aniline concentrations (0.08, 0.16 and 0,32 M) was absorbed into (CTS-g-GMA)-PEGDA crosslinked structure to form [(CTS-g-GMA)-PEGDA]-PANI electroconductive semi interpenetrating network...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29768946/neuroprotective-role-of-astroglia-in-parkinson-disease-by-reducing-oxidative-stress-through-dopamine-induced-activation-of-pentose-phosphate-pathway
#8
Kyoko Mashima, Shinichi Takahashi, Kazushi Minami, Yoshikane Izawa, Takato Abe, Naoki Tsukada, Takako Hishiki, Makoto Suematsu, Mayumi Kajimura, Norihiro Suzuki
Oxidative stress plays an important role in the onset and progression of Parkinson disease. Although released dopamine at the synaptic terminal is mostly reabsorbed by dopaminergic neurons, some dopamine is presumably taken up by astroglia. This study examined the dopamine-induced astroglial protective function through the activation of the pentose-phosphate pathway (PPP) to reduce reactive oxygen species (ROS). In vitro experiments were performed using striatal neurons and cortical or striatal astroglia prepared from Sprague-Dawley rats or C57BL/6 mice...
January 2018: ASN Neuro
https://www.readbyqxmd.com/read/29765393/support-of-new-triage-protocol-among-acute-stroke-care-providers
#9
Haitham M Hussein, David C Anderson
Objective: We conducted an online survey to gauge the acceptance of sending acute stroke patients with suspected large vessel occlusion (LVO) directly to an endovascular-capable hospital (ECH) even if that means bypassing a closer alteplase-capable hospital (ACH) without endovascular capability. Methods: The survey was composed of two cases of acute stroke, one with cortical symptoms suggestive of LVO and the other without. In each case, responders were asked to choose between triaging to a closer ACH or an ECH that is further away and to provide an opinion regarding the maximum extra travel time they would tolerate if they chose the ECH...
April 2018: Interventional Neurology
https://www.readbyqxmd.com/read/29763704/preparation-and-characterization-of-a-new-type-of-porous-starch-microspheres-psm-and-effect-of-physicochemical-properties-on-water-uptake-rate
#10
Jianjun Zhu, Wenzhong Sun, Zhiyun Meng, Xiaoxia Zhu, Hui Gan, Ruolan Gu, Zhuona Wu, Guifang Dou
Porous starch (PS) is a multifunctional biomaterial and has been widely applied in both pharmaceutical and food industry. This study was carried out to develop a new type of porous starch microspheres (PSM) through the dual-modification of the alcohol-alkaline treatment and inverse crosslinking-emulsion method, which could rapidly uptake water. The chemical and physical characteristics of the PSMs were determined by FTIR, SEM, XRD, DSC, ESD (equilibrium swelling ratio) and WS (water solubility). The results showed that PSMs could reach its saturated water uptake volume (about 1 mL/100 mg) in 60 s...
May 12, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29750408/non-covalent-small-molecule-kelch-like-ech-associated-protein-1-nuclear-factor-erythroid-2-related-factor-2-keap1-nrf2-inhibitors-and-their-potential-for-targeting-cns-diseases
#11
Jakob S Pallesen, Kim Tai Tran, Anders Bach
The transcription factor Nrf2 has a protective effect against oxidative stress and plays a major role in inflammation and CNS diseases. Inhibition of the protein-protein interaction (PPI) between Nrf2 and its repressor protein Keap1 leads to translocation of Nrf2 from the cytosol to the nucleus and expression of detoxifying antioxidant enzymes. To date, several non-covalent small-molecule Keap1-Nrf2 inhibitors have been identified; however, many of them contain carboxylic acids and are rather large in size, which likely prevents or decreases CNS permeability...
May 11, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29747676/epithelioid-cell-histiocytoma-with-sqstm1-alk-fusion-a-case-report
#12
Ryuko Nakayama, Yuki Togashi, Satoko Baba, Yo Kaku, Yuki Teramoto, Takaki Sakurai, Hironori Haga, Kengo Takeuchi
BACKGROUND: Epithelioid cell histiocytoma (ECH), which is also known as epithelioid benign fibrous histiocytoma, has been classified as a rare variant of fibrous histiocytoma (FH). However, the recent detection of ALK protein expression and/or ALK gene rearrangement in ECH suggests that it might be biologically different from conventional FH. CASE PRESENTATION: A 27-year-old male presented with nodule on his left foot, which had been present for 5 years. A macroscopic examination revealed an exophytic, hyperkeratotic nodule on the dorsum of the left foot...
May 10, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/29745220/prediction-of-binding-energy-of-keap1-interaction-motifs-in-the-nrf2-antioxidant-pathway-and-design-of-potential-high-affinity-peptides
#13
Mikko Karttunen, Wing-Yiu Choy, Elio A Cino
Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) is a transcription factor and principal regulator of the antioxidant pathway. The Kelch domain of Kelch-Like ECH-Associated Protein 1 (Keap1) binds to motifs in the N-terminal region of Nrf2, promoting its degradation. There is interest in developing ligands that can compete with Nrf2 for binding to Kelch, thereby activating its transcriptional activities, and increasing antioxidant levels. Using experimental ∆Gbind values of Kelch binding motifs determined previously, a revised hydrophobicity-based model was developed for estimating ∆Gbind from amino acid sequence, and applied to rank potential uncharacterized Kelch binding motifs identified from interaction databases and BLAST searches...
May 10, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29730008/ameliorative-effects-of-antrodia-cinnamomea-polysaccharides-against-cyclophosphamide-induced-immunosuppression-related-to-nrf2-ho-1-signaling-in-balb-c-mice
#14
Yange Liu, Anhui Yang, Yidi Qu, Zhuqian Wang, Yuqi Zhang, Yan Liu, Ning Wang, Lirong Teng, Di Wang
The objective of this study was to determine the ameliorative effects of Antrodia cinnamomea polysaccharide (ACPS) against cyclophosphamide (CTX)-induced immunosuppression in BALB/c mice. Four weeks of oral ACPS treatment successfully improved organ indexes and enhanced the function of T cells and the cytotoxicity of natural killer cells. CTX administration has been shown to notably decrease immunoglobulin A, G and M, interleukin 2, 6 and 12, and interferon α and γ levels in serum and in the spleen, and ACPS abolished these effects...
May 3, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29724169/development-of-a-melting-curve-based-multiplex-real-time-pcr-assay-for-simultaneous-detection-of-streptococcus-agalactiae-and-genes-encoding-resistance-to-macrolides-and-lincosamides
#15
Eliane Saori Otaguiri, Ana Elisa Belotto Morguette, Alexandre Tadachi Morey, Eliandro Reis Tavares, Gilselena Kerbauy, Rosângela S L de Almeida Torres, Mauricio Chaves Júnior, Maria Cristina Bronharo Tognim, Viviane Monteiro Góes, Marco Aurélio Krieger, Marcia Regina Eches Perugini, Lucy Megumi Yamauchi, Sueli Fumie Yamada-Ogatta
BACKGROUND: Streptococcus agalactiae or Group B Streptococcus (GBS) remains the leading cause of infections in newborns worldwilde. Prenatal GBS screening of pregnant women for vaginal-rectal colonization is recommended in many countries to manage appropriate intrapartum antimicrobial prophylaxis for those identified as carriers. In this study, a novel melting-curve based multiplex real-time PCR assay for the simultaneous detection of GBS and macrolide and lincosamide resistance markers was developed...
May 3, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29717933/the-keap1-nrf2-system-a-thiol-based-sensor-effector-apparatus-for-maintaining-redox-homeostasis
#16
Masayuki Yamamoto, Thomas W Kensler, Hozumi Motohashi
The Kelch-like ECH-associated protein 1-NF-E2-related factor 2 (KEAP1-NRF2) system forms the major node of cellular and organismal defense against oxidative and electrophilic stresses of both exogenous and endogenous origins. KEAP1 acts as a cysteine thiol-rich sensor of redox insults, whereas NRF2 is a transcription factor that robustly transduces chemical signals to regulate a battery of cytoprotective genes. KEAP1 represses NRF2 activity under quiescent conditions, whereas NRF2 is liberated from KEAP1-mediated repression on exposure to stresses...
July 1, 2018: Physiological Reviews
https://www.readbyqxmd.com/read/29713468/dietary-resveratrol-improves-antioxidant-status-of-sows-and-piglets-and-regulates-antioxidant-gene-expression-in-placenta-by-keap1-nrf2-pathway-and-sirt1
#17
Qingwei Meng, Tao Guo, Gaoqiang Li, Shishuai Sun, Shiqi He, Baojing Cheng, Baoming Shi, Anshan Shan
Background: Resveratrol, a plant phenol, affords protection against inflammation and oxidative stress. The objective of this study was to investigate the effects of dietary resveratrol supplementation during pregnancy and lactation on the antioxidant status of sows and piglets and on antioxidant gene expression and pathway in placenta. Methods: Forty sows were allotted to 2 dietary treatments 20 d after breeding. Sows were fed a control diet and a control diet with 300 mg/kg resveratrol...
2018: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/29713239/oxysterols-increase-inflammation-lipid-marker-levels-and-reflect-accelerated-endothelial-dysfunction-in-experimental-animals
#18
Tomasz Wielkoszyński, Jolanta Zalejska-Fiolka, Joanna K Strzelczyk, Aleksander J Owczarek, Armand Cholewka, Marcin Furmański, Agata Stanek
Objective: Oxidized cholesterol derivatives are thought to exert atherogenic effect thus adversely affecting vascular endothelium. The aim of the study was to assess the effect of 5 α ,6 α -epoxycholesterol on experimentally induced hypercholesterolemia in rabbits, and the levels of homocysteine (HCY), asymmetric dimethylarginine (ADMA), paraoxonase-1 (PON-1), and inflammatory parameters (IL-6, TNF- α , CRP). Material and methods: The rabbits were divided into 3 groups, 8 animals each, and fed with basic fodder (C), basic fodder plus cholesterol (Ch) or basic fodder plus 5 α ,6 α -epoxycholesterol, and unoxidized cholesterol (ECh)...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29709245/-persistence-internalization-and-translocation-of-escherichia-coli-o157-h7-o157-h16-and-o105ab-in-plants-and-tomato-fruits-solanum-lycopersicum-l
#19
Rosa L Ocaña de Jesús, Ana T Gutiérrez Ibáñez, Jesús R Sánchez Pale, María D Mariezcurrena Berasain, Carlos A Eslava Campos, Antonio Laguna Cerda
The presence of pathogenic bacteria, such as Escherichia coli affects the quality and safety of vegetables that are consumed fresh and is associated with serious health problems. The objective of this study was to determine if three different strains of E. coli can penetrate and remain in plants and tomato fruits. A completely randomized experimental design was followed for which a tomato crop ("Cid" variety) was established under greenhouse conditions and three treatments were evaluated, T1 (E. coli O157:H7), T2 (E...
April 27, 2018: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/29708970/histone-acetyltransferase-tgf-1-regulates-trichoderma-atroviride-secondary-metabolism-and-mycoparasitism
#20
Elida Yazmín Gómez-Rodríguez, Edith Elena Uresti-Rivera, Olga Araceli Patrón-Soberano, María Auxiliadora Islas-Osuna, Alberto Flores-Martínez, Lina Riego-Ruiz, María Teresa Rosales-Saavedra, Sergio Casas-Flores
Some filamentous fungi of the Trichoderma genus are used as biocontrol agents against airborne and soilborne phytopathogens. The proposed mechanism by which Trichoderma spp. antagonizes phytopathogens is through the release of lytic enzymes, antimicrobial compounds, mycoparasitism, and the induction of systemic disease-resistance in plants. Here we analyzed the role of TGF-1 (Trichoderma Gcn Five-1), a histone acetyltransferase of Trichoderma atroviride, in mycoparasitism and antibiosis against the phytopathogen Rhizoctonia solani...
2018: PloS One
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