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https://www.readbyqxmd.com/read/27847621/fusion-proteins-for-treatment-of-retinal-diseases-aflibercept-ziv-aflibercept-and-conbercept
#1
REVIEW
João Rafael de Oliveira Dias, Gabriel Costa de Andrade, Eduardo Amorim Novais, Michel Eid Farah, Eduardo Büchele Rodrigues
In the last few years, monoclonal antibodies have revolutionized the treatment of retinal neovascular diseases. More recently, a different class of drugs, fusion proteins, has provided an alternative treatment strategy with pharmacological differences. In addition to commercially available aflibercept, two other drugs, ziv-aflibercept and conbercept, have been studied in antiangiogenic treatment of ocular diseases. In this scenario, a critical review of the currently available data regarding fusion proteins in ophthalmic diseases may be a timely and important contribution...
2016: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/27830199/qualitative-evaluation-of-anterior-segment-in-angle-closure-disease-using-anterior-segment-optical-coherence-tomography
#2
Sasan Moghimi, Rebecca Chen, Nikoo Hamzeh, Nassim Khatibi, Shan C Lin
PURPOSE: To evaluate different mechanisms of primary angle closure (PAC) and to quantify anterior chamber (AC) parameters in different subtypes of angle closure disease using anterior segment optical coherence tomography (AS-OCT). METHODS: In this prospective study, 115 eyes of 115 patients with angle closure disease were included and categorized into three groups: 1) fellow eyes of acute angle closure (AAC; 40 eyes); 2) primary angle closure glaucoma (PACG; 39 eyes); and 3) primary angle closure suspect (PACS; 36 eyes)...
December 2016: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/27806381/integrin-alpha-9-blockade-suppresses-lymphatic-valve-formation-and-promotes-transplant-survival
#3
Gyeong Jin Kang, Tan Truong, Eric Huang, Valerie Su, Shaokui Ge, Lu Chen
Purpose: The lymphatic pathway mediates transplant rejection. We recently reported that lymphatic vessels develop luminal valves in the cornea during lymphangiogenesis, and these valves express integrin alpha 9 (Itga-9) and play a critical role in directing lymph flow. In this study, we used an allogeneic corneal transplantation model to investigate whether Itga-9 blockade could suppress valvulogenesis after transplantation, and how this effect would influence the outcomes of the transplants...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27702506/a-novel-ph-induced-thermosensitive-hydrogel-composed-of-carboxymethyl-chitosan-and-poloxamer-cross-linked-by-glutaraldehyde-for-ophthalmic-drug-delivery
#4
Shihui Yu, Xiaoyu Zhang, Guoxin Tan, Lei Tian, Dandan Liu, Yaxuan Liu, Xinggang Yang, Weisan Pan
In this work, a stimuli-responsive three dimensional cross-linked hydrogel system containing carboxymethyl chitosan (CMC) and poloxamer composed of a poly (ethylene oxide)/poly (propylene oxide)/poly (ethylene oxide) (PEO-PPO-PEO) block copolymer was constructed, and its aqueous solution was found to undergo a reversible sol-gel transition upon a temperature and/or pH change at a very low concentration. The hydrogels were synthesized via a cross-linking reaction using glutaraldehyde (GA) as the cross-linking agent...
January 2, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27662067/local-anesthetic-induced-myotoxicity-after-continuous-adductor-canal-block
#5
Joseph M Neal, Francis V Salinas, Daniel S Choi
OBJECTIVE: Local anesthetic-induced myotoxicity occurs consistently in animal models, yet is reported rarely in humans. Herein, we describe 3 sentinel cases of local anesthetic myotoxicity after continuous adductor canal block (ACB). CASE REPORT: Three patients underwent total knee arthroplasty that was managed with subarachnoid block plus ACB induced with 1.5% lidocaine or 1.5% mepivacaine bolus followed by 2% ropivacaine at 8 mL/h. Although initial postoperative recovery was normal, each patient on either postoperative day 1 or 2 developed progressive, profound weakness of the quadriceps muscles...
September 22, 2016: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/27493788/paradoxical-reactions-under-tnf-%C3%AE-blocking-agents-and-other-biological-agents-given-for-chronic-immune-mediated-diseases-an-analytical-and-comprehensive-overview
#6
REVIEW
Éric Toussirot, François Aubin
Paradoxical adverse events (PAEs) have been reported during biological treatment for chronic immune-mediated diseases. PAEs are defined as the occurrence during biological agent therapy of a pathological condition that usually responds to this class of drug. A wide range of PAEs have been reported including dermatological, intestinal and ophthalmic conditions, mainly with antitumour necrosis factor α (TNF-α) agents. True PAEs include psoriasis, Crohn's disease and hidradenitis suppurativa. Other PAEs may be qualified as borderline and include uveitis, scleritis, sarcoidosis and other granulomatous diseases (granuloma annulare, interstitial granulomatous dermatitis), vasculitis, vitiligo and alopecia areata...
2016: RMD Open
https://www.readbyqxmd.com/read/27428169/ultrafast-ultrasound-imaging-of-ocular-anatomy-and-blood-flow
#7
Raksha Urs, Jeffrey A Ketterling, Ronald H Silverman
PURPOSE: Ophthalmic ultrasound imaging is currently performed with mechanically scanned single-element probes. These probes have limited capabilities overall and lack the ability to image blood flow. Linear-array systems are able to detect blood flow, but these systems exceed ophthalmic acoustic intensity safety guidelines. Our aim was to implement and evaluate a new linear-array-based technology, compound coherent plane-wave ultrasound, which offers ultrafast imaging and depiction of blood flow at safe acoustic intensity levels...
July 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27354762/development-of-lifitegrast-a-novel-t-cell-inhibitor-for-the-treatment-of-dry-eye-disease
#8
REVIEW
Charles P Semba, Thomas R Gadek
Dry eye disease (DED) is a multifactorial disorder of the ocular surface characterized by symptoms of discomfort, decreased tear quality, and chronic inflammation that affects an estimated 20 million patients in the US alone. DED is associated with localized inflammation of the ocular surface and periocular tissues leading to homing and activation of T cells, cytokine release, and development of hyperosmolar tears. This inflammatory milieu results in symptoms of eye dryness and discomfort. Homing of T cells to the ocular surface is influenced by the binding of lymphocyte function-associated antigen-1 (LFA-1; CD11a/CD18; αLβ2), a cell surface adhesion protein, to its cognate ligand, intercellular adhesion molecule-1 (ICAM-1; CD54), which is expressed on inflamed ocular/periocular epithelium and vascular endothelium...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27234973/aflibercept-exhibits-vegf-binding-stoichiometry-distinct-from-bevacizumab-and-does-not-support-formation-of-immune-like-complexes
#9
Douglas A MacDonald, Joel Martin, Kathir K Muthusamy, Jiann-Kae Luo, Erica Pyles, Ashique Rafique, Tammy Huang, Terra Potocky, Yang Liu, Jingtai Cao, Françoise Bono, Nathalie Delesque, Pierre Savi, John Francis, Ali Amirkhosravi, Todd Meyer, Carmelo Romano, Meredith Glinka, George D Yancopoulos, Neil Stahl, Stanley J Wiegand, Nicholas Papadopoulos
Anti-vascular endothelial growth factor (VEGF) therapies have improved clinical outcomes for patients with cancers and retinal vascular diseases. Three anti-VEGF agents, pegaptanib, ranibizumab, and aflibercept, are approved for ophthalmic indications, while bevacizumab is approved to treat colorectal, lung, and renal cancers, but is also used off-label to treat ocular vascular diseases. The efficacy of bevacizumab relative to ranibizumab in treating neovascular age-related macular degeneration has been assessed in several trials...
July 2016: Angiogenesis
https://www.readbyqxmd.com/read/27199572/profound-vascular-stasis-of-retina-and-optic-nerve-following-retrobulbar-anesthesia
#10
Bozho Todorich, Paul Hahn
INTRODUCTION: We aim to describe a mechanism of vision loss following vitrectomy surgery with retrobulbar block (RBB) associated with severe vascular stasis of the optic nerve and macula in order to improve safety of local anesthesia for ophthalmic surgery. CASE PRESENTATION: We report three cases of patients who underwent pars plana vitrectomy (PPV) with retrobulbar anesthesia with no retrobulbar hemorrhage or elevated intraocular pressure (IOP). At the beginning, in each case, hypoperfusion of optic nerve and macula was noted...
2016: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/27103010/%C3%AE-lipoic-acid-in-soluplus-%C3%A2-polymeric-nanomicelles-for-ocular-treatment-of-diabetes-associated-corneal-diseases
#11
Fernando Alvarez-Rivera, David Fernández-Villanueva, Angel Concheiro, Carmen Alvarez-Lorenzo
α-Lipoic acid (ALA) is a powerful antioxidant valuable for prevention and treatment of ophthalmic complications such as diabetic keratopathy and retinopathy. The aim of this work was to develop micelle-based formulations that can enhance the solubility, stability, and corneal permeability of ALA. Compared to a conventional surfactant (sodium dioctylsulfosuccinate), Soluplus(®) (polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol copolymer) led to smaller micelles (70-80 vs. 240-528 nm) with improved ability to solubilize ALA, maintaining ocular compatibility (Hens Egg Test on the Chorio-Allantoic Membrane)...
September 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27065376/swept-source-optical-coherence-tomography-and-oct-angiography-of-minocycline-induced-retinal-and-systemic-hyperpigmentation
#12
Jesse J Jung, Michael H Chen, Andrew L Sorenson, Soraya Rofagha
This is a report of an 80-year-old man with a history of rosacea and rhinophyma treated for 15 years with oral minocycline who developed significant minocycline-induced hyperpigmentation. He also had a history of Fuchs' endothelial dystrophy and had undergone penetrating keratoplasty in the right eye. Best-corrected visual acuity was 20/60 in both eyes. Examination revealed slate-grey hyperpigmentation of his body, face, and sclera and black, confluent pigmentation in the central maculae of both eyes. Green wavelength fundus autofluorescence demonstrated speckled hyperautofluorescence in the right eye, and swept-source OCT and OCTA demonstrated pigmented epithelial detachments and significant signal blocking without choroidal neovascularization...
April 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/27013746/comparative-evaluation-of-two-different-loading-doses-of-dexmedetomidine-with-midazolam-fentanyl-for-sedation-in-vitreoretinal-surgery-under-peribulbar-anaesthesia
#13
Suman Shree Ramaswamy, B Parimala
BACKGROUND AND AIMS: Midazolam-fentanyl (MDZ:FEN) combination has been routinely used for intravenous sedation in ophthalmic surgeries. Dexmedetomidine (DEX), a recent α2 adrenoreceptor agonist indicated for sedation for ophthalmic use at a loading dose of 0.5 μg/kg over 10 min, can cause deeper plane of sedation and surgeon dissatisfaction. Therefore, we proposed to evaluate the efficacy and safety of two different loading doses of DEX. METHODS: In a prospective study, 60 patients aged 50-70 years, scheduled for retinal surgery under peribulbar block were divided equally to receive either MDZ:FEN or DEX 0...
February 2016: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/27010283/development-of-retrobulbar-and-auriculopalpebral-nerve-blocks-in-california-sea-lions-zalophus-californianus
#14
J Gutiérrez, C Simeone, F Gulland, S Johnson
Eye lesions are commonly observed in pinnipeds. Clinical assessment is challenging because animals are often blepharospastic and under inhalant anesthesia the globe rotates ventrally, making observation difficult. Retrobulbar and auriculopalpebral nerve block techniques have been developed in other species to alleviate these difficulties and allow for a more thorough ophthalmic exam. Ocular nerve block techniques were developed for California sea lions (CSLs) (Zalophus californianus) using lidocaine hydrochloride 2%...
March 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/26985257/cavernous-sinus-dural-arteriovenous-fistula-patients-presenting-with-headache-as-an-initial-symptom
#15
Motohiro Nomura, Kentaro Mori, Akira Tamase, Tomoya Kamide, Syunsuke Seki, Yu Iida, Yuichi Kawabata, Tatsu Nakano, Hiroshi Shima, Hiroki Taguchi
Cavernous sinus (CS) dural arteriovenous fistula (dAVF) patients presenting with only headache as an initial symptom are not common. Patients with CS-dAVF commonly present with symptoms related to their eyes. In all three patients, headache was the initial symptom. Other symptoms related to the eyes developed 1 - 7 months after headache. In one patient, headache was controlled by sumatriptan succinate, but not diclofenac sodium or loxoprofen sodium. In another patient, headache was controlled by loxoprofen sodium...
April 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/26955313/effect-of-addition-of-magnesium-to-local-anesthetics-for-peribulbar-block-a-prospective-randomized-double-blind-study
#16
R Sinha, A Sharma, B R Ray, R Chandiran, C Chandralekha, R Sinha
BACKGROUND: Magnesium sulphate has been used along with local anesthetics in different regional blocks and found to be effective in decreasing the time of onset of the block and increasing the duration of the block. OBJECTIVE: To evaluate the effect of addition of magnesium sulfate to standard local anesthetics mixture on the time for onset of the globe and lid akinesia for peribulbar block in ophthalmic surgeries. MATERIALS AND METHODS: Sixty patients with American Society of Anesthesiologists status I to III undergoing ophthalmic surgery under peribulbar block were included in this study...
January 2016: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/26952175/dexmedetomidine-as-an-additive-to-local-anesthetics-compared-with-intravenous-dexmedetomidine-in-peribulbar-block-for-cataract-surgery
#17
A M Abdelhamid, Aaa Mahmoud, M M Abdelhaq, H M Yasin, Asm Bayoumi
BACKGROUND: No studies compared parenteral dexmedetomidine with its use as an adjuvant to ophthalmic block. We compared between adding dexmedetomidine to bupivacaine in peribulbar block and intravenous (IV) dexmedetomidine during peribulbar block for cataract surgery. MATERIALS AND METHODS: A prospective, randomized, double-blind study on 90 patients for cataract surgery under peribulbar anesthesia. Study included three groups; all patients received 10 ml of peribulbar anesthesia and IV infusion of drugs as follows: Group I: Received a mixture of bupivacaine 0...
January 2016: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/26895612/macroscopic-techniques-for-ophthalmic-tumor-specimens
#18
Fiona Roberts
This article explores the range of tumor specimens that may be submitted to ophthalmic pathology. The handling of complex enucleation and exenteration is described along with smaller eyelid, conjunctival and corneal specimens. The importance of a good understanding of the unique anatomy of the ocular region and detailed clinical information is emphasized as this results in the taking of appropriate blocks for histology and consequently clinically helpful reports. Recommendations for handling specimens where further tissue is required for molecular studies is discussed...
May 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/26831940/the-gatekeepers-in-the-mouse-ophthalmic-artery-endothelium-dependent-mechanisms-of-cholinergic-vasodilation
#19
Caroline Manicam, Julia Staubitz, Christoph Brochhausen, Franz H Grus, Norbert Pfeiffer, Adrian Gericke
Cholinergic regulation of arterial luminal diameter involves intricate network of intercellular communication between the endothelial and smooth muscle cells that is highly dependent on the molecular mediators released by the endothelium. Albeit the well-recognized contribution of nitric oxide (NO) towards vasodilation, the identity of compensatory mechanisms that maintain vasomotor tone when NO synthesis is deranged remain largely unknown in the ophthalmic artery. This is the first study to identify the vasodilatory signalling mechanisms of the ophthalmic artery employing wild type mice...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26800356/risk-of-hemorrhage-during-needle-based-ophthalmic-regional-anesthesia-in-patients-taking-antithrombotics-a-systematic-review
#20
REVIEW
Augusto Takaschima, Patricia Marchioro, Thiago M Sakae, André L Porporatti, Luis André Mezzomo, Graziela De Luca Canto
BACKGROUND: Patients undergoing ophthalmic surgery are usually elderly and, due to systemic disease, may be on long-term therapy, such as antithrombotic agents. Rates of hemorrhagic complications associated with invasive procedures may be increased by the use of anticoagulants and antiplatelet agents. OBJECTIVE: To compare the incidence of hemorrhagic complications in patients undergoing needle-based ophthalmic regional anesthesia between patients on antithrombotic therapy and those not on such therapy...
2016: PloS One
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