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https://www.readbyqxmd.com/read/29161513/insights-into-molecular-basis-of-acute-contact-toxicity-of-diverse-organic-chemical-in-honey-bee
#1
Xiao Li, Yuan Zhang, Hongna Chen, Huanhuan Li, Yong Zhao
The chemical pollutants, including pesticides and other industrial chemicals, have resulted in significant risks to the whole ecosystem. Therefore, the ecological risk assessment of chemicals is vital and necessary. Since honey bee (Apis mellifera) is probably among the most exposed species to the polluting chemicals, we focused on the in silico estimation of honey bee toxicity (HBT) of chemical and the analysis of the relevance of chemical HBT and several key physical-chemical properties and structural characteristics...
November 21, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29161264/proprioceptive-assessment-in-clinical-settings-evaluation-of-joint-position-sense-in-upper-limb-post-stroke-using-a-robotic-manipulator
#2
Sara Contu, Asif Hussain, Simone Kager, Aamani Budhota, Vishwanath A Deshmukh, Christopher W K Kuah, Lester H L Yam, Liming Xiang, Karen S G Chua, Lorenzo Masia, Domenico Campolo
Proprioception is a critical component for motor functions and directly affects motor learning after neurological injuries. Conventional methods for its assessment are generally ordinal in nature and hence lack sensitivity. Robotic devices designed to promote sensorimotor learning can potentially provide quantitative precise, accurate, and reliable assessments of sensory impairments. In this paper, we investigate the clinical applicability and validity of using a planar 2 degrees of freedom robot to quantitatively assess proprioceptive deficits in post-stroke participants...
2017: PloS One
https://www.readbyqxmd.com/read/29159857/methylphenidate-for-children-and-adolescents-with-autism-spectrum-disorder
#3
REVIEW
Nancy Sturman, Laura Deckx, Mieke L van Driel
BACKGROUND: Children with autistic spectrum disorder (ASD) frequently present with inattention, impulsivity and hyperactivity, which are the cardinal symptoms of attention deficit hyperactivity disorder (ADHD). The effectiveness of methylphenidate, a commonly used ADHD treatment, is therefore of interest in these children. OBJECTIVES: To assess the effects of methylphenidate for symptoms of ADHD (inattention, impulsivity and hyperactivity) and ASD (impairments in social interaction and communication, and repetitive, restricted or stereotypical behaviours) in children and adolescents aged 6 to 18 years with ASD...
November 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29159811/a-deep-learning-method-for-classifying-mammographic-breast-density-categories
#4
Aly A Mohamed, Wendie A Berg, Hong Peng, Yahong Luo, Rachel C Jankowitz, Shandong Wu
PURPOSE: Mammographic breast density is an established risk marker for breast cancer and is visually assessed by radiologists in routine mammogram image reading, using four qualitative Breast Imaging and Reporting Data System (BI-RADS) breast density categories. It is particularly difficult for radiologists to consistently distinguish the two most common and most variably assigned BI-RADS categories, i.e., "scattered density" and "heterogeneously dense". The aim of this work was to investigate a deep learning-based breast density classifier to consistently distinguish these two categories, aiming at providing a potential computerized tool to assist radiologists in assigning a BI-RADS category in current clinical workflow...
November 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/29159665/functional-rostro-caudal-gradient-in-the-human-posterior-lateral-frontal-cortex
#5
Céline Amiez, Michael Petrides
The present study examined the hypothesis that the posterior motor/premotor region of the lateral frontal cortex is functionally organized along a rostro-caudal axis. During functional magnetic resonance imaging scanning, the subjects performed various tasks assessing basic saccadic eye or hand actions and also tasks requiring the cognitive selection between competing hand or eye movements based on previously learned conditional relations (if A, select movement X, but if B select movement Y). Subject-by-subject analysis demonstrated precise relationships between the foci of functional activity and specific sulci...
November 20, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/29159197/donepezil-enhances-understanding-of-degraded-speech-in-alzheimer-s-disease
#6
Chris J D Hardy, Yun T Hwang, Rebecca L Bond, Charles R Marshall, Basil H Ridha, Sebastian J Crutch, Martin N Rossor, Jason D Warren
Auditory dysfunction under complex, dynamic listening conditions is a clinical hallmark of Alzheimer's disease (AD) but challenging to measure and manage. Here, we assessed understanding of sinewave speech (a paradigm of degraded speech perception) and general cognitive abilities in 17 AD patients, before and following a 10 mg dose of donepezil. Relative to healthy older individuals, patients had impaired sinewave speech comprehension that was selectively ameliorated by donepezil. Our findings demonstrate impaired perception of degraded speech in AD but retained perceptual learning capacity that can be harnessed by acetylcholinesterase inhibition, with implications for designing communication interventions and acoustic environments in dementia...
November 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29159057/gray-matter-atrophy-patterns-in-multiple-sclerosis-a-10-year-source-based-morphometry-study
#7
Niels Bergsland, Dana Horakova, Michael G Dwyer, Tomas Uher, Manuela Vaneckova, Michaela Tyblova, Zdenek Seidl, Jan Krasensky, Eva Havrdova, Robert Zivadinov
Objectives: To investigate spatial patterns of gray matter (GM) atrophy and their association with disability progression in patients with early relapsing-remitting multiple sclerosis (MS) in a longitudinal setting. Methods: Brain MRI and clinical neurological assessments were obtained in 152 MS patients at baseline and after 10 years of follow-up. Patients were classified into those with confirmed disability progression (CDP) (n = 85) and those without CDP (n = 67) at the end of the study...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29158886/noninvasive-evaluation-of-portal-hypertension-using-a-supervised-learning-technique
#8
Mindaugas Marozas, Romanas Zykus, Andrius Sakalauskas, Limas Kupčinskas, Arūnas Lukoševičius
Portal hypertension (PHT) is a key event in the evolution of different chronic liver diseases and leads to the morbidity and mortality of patients. The traditional reliable PHT evaluation method is a hepatic venous pressure gradient (HVPG) measurement, which is invasive and not always available or acceptable to patients. The HVPG measurement is relatively expensive and depends on the experience of the physician. There are many potential noninvasive methods to predict PHT, of which liver transient elastography is determined to be the most accurate; however, even transient elastography lacks the accuracy to be a perfect noninvasive diagnostic method of PHT...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29158675/transplantation-of-bone-mesenchymal-stem-cells-promotes-angiogenesis-and-improves-neurological-function-after-traumatic-brain-injury-in-mouse
#9
Shewei Guo, Yingwei Zhen, Anran Wang
Traumatic brain injury (TBI) has emerged as a leading cause of mortality and morbidity worldwide. Transplantation of bone mesenchymal stem cells (BMSCs) has emerged as a promising treatment for various central nervous system diseases. This study aims to evaluate the effect of BMSCs transplantation by intravenous injection on neurological function and angiogenesis of the TBI mice. C57BL/6 male mice were randomly divided into four groups: control, sham, TBI, and BMSC. Functional neurological evaluation was performed 1, 4, 7, 14, and 21 days after TBI using neurological severity scores...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29158606/detecting-macroecological-patterns-in-bacterial-communities-across-independent-studies-of-global-soils
#10
Kelly S Ramirez, Christopher G Knight, Mattias de Hollander, Francis Q Brearley, Bede Constantinides, Anne Cotton, Si Creer, Thomas W Crowther, John Davison, Manuel Delgado-Baquerizo, Ellen Dorrepaal, David R Elliott, Graeme Fox, Robert I Griffiths, Chris Hale, Kyle Hartman, Ashley Houlden, David L Jones, Eveline J Krab, Fernando T Maestre, Krista L McGuire, Sylvain Monteux, Caroline H Orr, Wim H van der Putten, Ian S Roberts, David A Robinson, Jennifer D Rocca, Jennifer Rowntree, Klaus Schlaeppi, Matthew Shepherd, Brajesh K Singh, Angela L Straathof, Jennifer M Bhatnagar, Cécile Thion, Marcel G A van der Heijden, Franciska T de Vries
The emergence of high-throughput DNA sequencing methods provides unprecedented opportunities to further unravel bacterial biodiversity and its worldwide role from human health to ecosystem functioning. However, despite the abundance of sequencing studies, combining data from multiple individual studies to address macroecological questions of bacterial diversity remains methodically challenging and plagued with biases. Here, using a machine-learning approach that accounts for differences among studies and complex interactions among taxa, we merge 30 independent bacterial data sets comprising 1,998 soil samples from 21 countries...
November 20, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/29158112/subtle-behavioral-changes-and-increased-prefrontal-hippocampal-network-synchronicity-in-app-nl-g-f-mice-before-prominent-plaque-deposition
#11
Amira Latif Hernandez, Disha Shah, Kathleen Craessaerts, Takaomi Saido, Takashi Saito, Bart De Strooper, Annemie Van der Linden, Rudi D'Hooge
Amyloid-β (Aβ) peptides occur in the brains of patients with Alzheimer's disease (AD), but their role in functional impairment is still debated. High levels of APP and APP fragments in mice that overexpress APP might confound their use in preclinical research. We examined the occurrence of behavioral, cognitive and neuroimaging changes in APP(NL-G-F) knock-in mice that display Aβ42 amyloidosis in the absence of APP overexpression. Female APP(NL-G-F) mice (carrying Swedish, Iberian and Arctic APP mutations) were compared to APP(NL) mice (APP Swedish) at 3, 7 and 10 months...
November 17, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29157753/validit%C3%A3-et-reproductibilit%C3%A3-de-deux-grilles-d%C3%A2-observation-des-comp%C3%A3-tences-cliniques-des-internes-en-des-de-m%C3%A3-decine-interne
#12
P Pottier, F Cohen Aubart, O Steichen, M Desprets, M Pha, A Espitia, S Georgin-Lavialle, A Morel, J B Hardouin
INTRODUCTION: The revision of the French medical studies' third cycle ought to be competency-based. In internal medicine, theoretical and practical knowledge will be assessed online with e-learning and e-portfolio. In parallel, a reflection about clinical skills assessment forms is currently ongoing. In this context, our aim was to assess the reproducibility and validity of two assessment forms based on direct clinical observation. METHOD: A prospective and multicentric study has been conducted from November 2015 to October 2016 aiming at evaluating the French translations of the MINI-Clinical Examination Exercice (MINI-CEX) and the Standardized Patient Satisfaction Questionnaire (SPSQ)...
November 17, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29157568/providing-primary-care-using-an-interprofessional-collaborative-practice-model-what-clinicians-have-learned
#13
Cynthia S Selleck, Matthew Fifolt, Heidi Burkart, Jennifer Sandson Frank, William A Curry, Lisle S Hites
This article details a nurse-led, interprofessional collaborative practice (IPCP) model that was developed to provide primary care to a medically indigent population in Birmingham, Alabama. Funding to develop and implement this project came from a federal Nurse Education, Practice, Quality and Retention award to the University of Alabama at Birmingham (UAB) School of Nursing, with additional support coming from the UAB Hospital and Health System. The clinic is housed within a local community-based, non-profit organization and all services, including supplies and pharmaceuticals, are provided free of charge to this vulnerable population...
November 2017: Journal of Professional Nursing: Official Journal of the American Association of Colleges of Nursing
https://www.readbyqxmd.com/read/29157445/an-ensemble-deep-learning-based-approach-for-red-lesion-detection-in-fundus-images
#14
José Ignacio Orlando, Elena Prokofyeva, Mariana Del Fresno, Matthew B Blaschko
BACKGROUND AND OBJECTIVES: Diabetic retinopathy (DR) is one of the leading causes of preventable blindness in the world. Its earliest sign are red lesions, a general term that groups both microaneurysms (MAs) and hemorrhages (HEs). In daily clinical practice, these lesions are manually detected by physicians using fundus photographs. However, this task is tedious and time consuming, and requires an intensive effort due to the small size of the lesions and their lack of contrast. Computer-assisted diagnosis of DR based on red lesion detection is being actively explored due to its improvement effects both in clinicians consistency and accuracy...
January 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29157239/does-faculty-development-influence-the-quality-of-in-training-evaluation-reports-in-pharmacy
#15
Kerry Wilbur
BACKGROUND: In-training evaluation reports (ITERs) of student workplace-based learning are completed by clinical supervisors across various health disciplines. However, outside of medicine, the quality of submitted workplace-based assessments is largely uninvestigated. This study assessed the quality of ITERs in pharmacy and whether clinical supervisors could be trained to complete higher quality reports. METHODS: A random sample of ITERs submitted in a pharmacy program during 2013-2014 was evaluated...
November 21, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29157232/implementation-of-an-interprofessional-team-based-learning-program-involving-seven-undergraduate-health-and-social-care-programs-from-two-universities-and-students-evaluation-of-their-readiness-for-interprofessional-learning
#16
Lap Ki Chan, Fraide Ganotice, Frances Kam Yuet Wong, Chak Sing Lau, Susan M Bridges, Celia Hoi Yan Chan, Namkiu Chan, Phoebe Wing Lam Chan, Hai Yong Chen, Julie Yun Chen, Jody Kwok Pui Chu, Charlene C Ho, Jacqueline Mei Chi Ho, Tai Pong Lam, Veronica Suk Fun Lam, Qingyun Li, Jian Gang Shen, Julian Alexander Tanner, Winnie Wan Yee Tso, Arkers Kwan Ching Wong, Gordon Tin Chun Wong, Janet Yuen Ha Wong, Nai Sum Wong, Alan Worsley, Lei King Yu, Tin Pui Yum
BACKGROUND: Interprofessional learning is gaining momentum in revolutionizing healthcare education. During the academic year 2015/16, seven undergraduate-entry health and social care programs from two universities in Hong Kong took part in an interprofessional education program. Based on considerations such as the large number of students involved and the need to incorporate adult learning principles, team-based learning was adopted as the pedagogy for the program, which was therefore called the interprofessional team-based learning program (IPTBL)...
November 21, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29157229/computer-model-for-the-cardiovascular-system-development-of-an-e-learning-tool-for-teaching-of-medical-students
#17
David Roy Warriner, Martin Bayley, Yubing Shi, Patricia Victoria Lawford, Andrew Narracott, John Fenner
BACKGROUND: This study combined themes in cardiovascular modelling, clinical cardiology and e-learning to create an on-line environment that would assist undergraduate medical students in understanding key physiological and pathophysiological processes in the cardiovascular system. METHODS: An interactive on-line environment was developed incorporating a lumped-parameter mathematical model of the human cardiovascular system. The model outputs were used to characterise the progression of key disease processes and allowed students to classify disease severity with the aim of improving their understanding of abnormal physiology in a clinical context...
November 21, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29156792/liquid-biopsy-in-colon-cancer-comparison-of-different-circulating-dna-extraction-systems-following-absolute-quantification-of-kras-mutations-using-intplex-allele-specific-pcr
#18
Vera Kloten, Nadine Rüchel, Nadina Ortiz Brüchle, Janina Gasthaus, Nils Freudenmacher, Florian Steib, Jolein Mijnes, Julian Eschenbruch, Marcel Binnebösel, Ruth Knüchel, Edgar Dahl
Non-invasive molecular analysis of circulating tumor DNA (ctDNA) is a promising application in personalized cancer management, although there is still much to learn about the biological characteristics of ctDNA. The present study compared absolute amounts of KRAS mutated ctDNA and total circulating cell-free DNA (cfDNA) in colorectal cancer (CRC) patients (n=50) from various stages and healthy controls (n=8) by Intplex allele-specific and digital droplet PCR. In addition, the impact of two prominent extraction techniques (silica-based membrane vs...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156410/how-do-we-learn-to-kill-in-volleyball-the-role-of-working-memory-capacity-and-expertise-in-volleyball-motor-learning
#19
Elisa Bisagno, Sergio Morra
This study examines young volleyball players' learning of increasingly complex attack gestures. The main purpose of the study was to examine the predictive role of a cognitive variable, working memory capacity (or "M capacity"), in the acquisition and development of motor skills in a structured sport. Pascual-Leone's theory of constructive operators (TCO) was used as a framework; it defines working memory capacity as the maximum number of schemes that can be simultaneously activated by attentional resources...
November 17, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/29156276/formation-and-degradation-of-n-oxide-venlafaxine-during-ozonation-and-biological-post-treatment
#20
Ines Zucker, Hadas Mamane, Alon Riani, Igal Gozlan, Dror Avisar
While ozonation is considered an efficient treatment to eliminate trace organic compounds (TrOCs) from secondary wastewater effluents, the presence and persistence of transformation products (TPs) resulting from ozonation of TrOCs is a major concern that should be assessed prior to effluent discharge to the environment. Venlafaxine (VLX), an environmentally relevant tertiary amine-containing TrOC, was chosen as the model for this study. TP analysis confirmed that the lone electron pair of the non-protonated amine are the predominant site of oxidant attack, and therefore strongly affected by pH value and VLX speciation...
November 17, 2017: Science of the Total Environment
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