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https://www.readbyqxmd.com/read/29228475/persistente-ulzera-durch-crack-konsum
#1
Serena Lembo, Angela Patrì, Anna Balato, Luciano Petrillo
No abstract text is available yet for this article.
December 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29228388/caspase-inhibition-reduces-hepatic-tissue-factor-driven-coagulation-in-vitro-and-in-vivo
#2
Anna K Kopec, Alfred P Spada, Patricia C Contreras, Nigel Mackman, James P Luyendyk
Tissue factor (TF) is the primary activator of the blood coagulation cascade. Liver parenchymal cells (i.e., hepatocytes) express TF in a molecular state that lacks procoagulant activity. Hepatocyte apoptosis is an important feature of acute and chronic liver diseases, and Fas-induced apoptosis increases hepatocyte TF procoagulant activity in vitro. We determined the impact of a pan-caspase inhibitor, IDN-7314, on hepatocyte TF activity in vitro and TF-mediated coagulation in vivo. Treatment of primary mouse hepatocytes with the Fas death receptor ligand (Jo2, 0...
December 7, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29228381/the-etiology-and-impact-of-co-infections-in-children-hospitalized-with-community-acquired-pneumonia
#3
Vikki G Nolan, Sandra R Arnold, Anna M Bramley, Krow Ampofo, Derek J Williams, Carlos G Grijalva, Wesley H Self, Evan J Anderson, Richard G Wunderink, Kathryn M Edwards, Andrew T Pavia, Seema Jain, Jonathan A McCullers
Background: Recognition that co-infections are common in children with community-acquired pneumonia (CAP) is increasing, but gaps remain in our understanding of their frequency and importance. Methods: We analyzed data from 2219 children hospitalized with CAP and compared demographics, clinical characteristics, and outcomes between groups with viruses alone, bacteria alone, or co-infections. We also assessed the frequency of selected pairings of co-detected pathogens and their clinical characteristics...
December 8, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29228373/medical-treatment-or-surgery-for-colorectal-endometriosis-results-of-a-shared-decision-making-approach
#4
Paolo Vercellini, Maria Pina Frattaruolo, Riccardo Rosati, Dhouha Dridi, Anna Roberto, Paola Mosconi, Olga De Giorgi, Fulvia Milena Cribiù, Edgardo Somigliana
STUDY QUESTION: What is the degree of patient satisfaction in women with symptomatic colorectal endometriosis who choose medical or surgical treatment after a shared decision-making (SDM) process? SUMMARY ANSWER: The degree of satisfaction with treatment was high both in women who chose medical treatment with a low-dose oral contraceptive (OCP) or a progestin, and in those who chose to undergo surgical resection of bowel endometriosis. WHAT IS KNOWN ALREADY: Hormonal therapies and surgery for colorectal endometriosis have been investigated in non-comparative studies with inconsistent results...
December 8, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29228291/the-disappearing-basal-ganglia-sign
#5
Mohamad Syafeeq Faeez Md Noh, Anna Misyail Abdul Rashid
No abstract text is available yet for this article.
December 7, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29228286/cut-and-paste-transposons-in-fungi-with-diverse-lifestyles
#6
Anna Muszewska, Kamil Steczkiewicz, Marta Stepniewska-Dziubinska, Krzysztof Ginalski
Transposons (TEs) shape genomes via recombination and transposition, lead to chromosomal rearrangements, create new gene neighbourhoods and alter gene expression. They play key roles in adaptation either to symbiosis in Amanita genus or to pathogenicity in Pyrenophora tritici-repentis. Despite growing evidence of their importance, the abundance and distribution of mobile elements replicating in a "cut and paste" fashion is barely described so far. In order to improve our knowledge on this old and ubiquitous class of transposable elements, 1,730 fungal genomes were scanned using both de novo and homology-based approaches...
December 8, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29228190/assessing-the-diversity-of-the-g23-gene-of-t4-like-bacteriophages-from-lake-baikal-with-high-throughput-sequencing
#7
Sergey Potapov, Olga Olga, Andrey Krasnopeev, Anna Gladkikh, Marsel Kabilov, Aleksey Tupikin, Tatyana V Butina
Based on second generation sequencing (MiSeq platform), we determined the genetic diversity of T4-like bacteriophages of the family Myoviridae by analysing fragments of the major capsid protein gene g23 in the plankton of Lake Baikal. The sampling depth in our study was significantly higher than in those obtained by the Sanger method before. We obtained 33701 sequences of the g23 gene fragments, 141 OTUs of which were identified. 86 OTUs (60.9%) had the closest relatives from lakes Bourget and Annecy, and 28 OTUs (19...
December 5, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29228040/consequences-of-supplying-methyl-donors-during-pregnancy-on-the-methylome-of-the-offspring-from-lactating-and-non-lactating-dairy-cattle
#8
Alex Bach, Anna Aris, Isabel Guasch
The aim of this study was to evaluate the potential effects of methyl donor supplementation of pregnant animals in the presence or absence of a concomitant lactation on the methylome of the offspring. Twenty Holstein cows, 10 nulliparous (non-lactating while pregnant) and 10 multiparous (lactating while pregnant) were blocked by parity and randomly assigned to an i.m. weekly injections of a placebo (CTRL) or a solution containing methyl donors (MET). After calving, 5 calves randomly selected from each treatment (two born to non-lactating and three to lactating dams) were blood-sampled to determine their full methylome...
2017: PloS One
https://www.readbyqxmd.com/read/29228033/visual-mismatch-negativity-to-vanishing-parts-of-objects-in-younger-and-older-adults
#9
István Sulykos, Zsófia Anna Gaál, István Czigler
We investigated visual mismatch negativity (vMMN) to vanishing parts of continuously present objects by comparing the event-related potentials (ERPs) to infrequently (deviant) and frequently (standard) disappearing parts of the objects. This paradigm both excludes low-level stimulus-specific adaptation differences between the responses to deviants and standards, and increases the ecological validity of the stimuli. In comparison to frequently disappearing parts of the stimulus objects, infrequently vanishing parts elicited posterior negative event-related brain activity (vMMN)...
2017: PloS One
https://www.readbyqxmd.com/read/29227995/restoration-of-floodplain-meadows-effects-on-the-re-establishment-of-mosses
#10
Dorota Michalska-Hejduk, Grzegorz J Wolski, Matthias Harnisch, Annette Otte, Anna Bomanowska, Tobias W Donath
Vascular plants serve as target species for the evaluation of restoration success as they account for most of the plant species diversity and vegetation cover. Although bryophytes contribute considerably to the species diversity of meadows, they are rarely addressed in restoration projects. This project is a first step toward making recommendations for including mosses in alluvial floodplain restoration projects. The opportunity to assess the diversity and ecological requirements of mosses on floodplain meadows presented itself within the framework of a vegetation monitoring that took place in 2014 on meadows located along the northern Upper Rhine...
2017: PloS One
https://www.readbyqxmd.com/read/29227889/nursing-and-midwifery-students-stress-and-coping-during-their-undergraduate-education-programmes-an-integrative-review
#11
REVIEW
Bridie McCarthy, Anna Trace, Moira O'Donovan, Caroline Brady-Nevin, Margaret Murphy, Maria O'Shea, Patricia O'Regan
OBJECTIVES: The aim of this review is to examine the literature related to the sources of stress, coping mechanisms and interventions to support undergraduate nursing and midwifery students to cope with stress during their undergraduate education. DESIGN: Integrative literature review. DATA SOURCES: The databases CINAHL, PubMed and PsycINFO were searched for articles published between 2010 and 2016. Search terms in various combinations were used for example; student nurse, student midwife, undergraduate, stress, coping and interventions...
November 28, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/29227790/interpersonal-and-intrapersonal-emotional-processes-in-individuals-treated-for-alcohol-use-disorder-and-non-addicted-healthy-individuals
#12
Maciej Kopera, Elisa M Trucco, Andrzej Jakubczyk, Hubert Suszek, Aneta Michalska, Aleksandra Majewska, Natalia Szejko, Agata Łoczewska, Aleksandra Krasowska, Anna Klimkiewicz, Kirk J Brower, Robert A Zucker, Marcin Wojnar
INTRODUCTION: Prior work largely confirms the presence of various emotional processing deficits among individuals with an alcohol use disorder (AUD); however, their specificity and relevance still warrant investigation. The aim of the current study was to compare selected aspects of emotional processing (i.e., mental state recognition, alexithymia, and emotional intelligence) between individuals treated for an AUD and healthy individuals. METHODS: The AUD sample consisted of 92 abstinent men with AUD who were participating in an 8-week inpatient abstinence-based treatment program in Warsaw, Poland...
December 5, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29227675/an-ab-initio-exploration-of-the-bergman-cyclization
#13
Adam R Luxon, Natalie Orms, René P F Kanters, Anna I Krylov, Carol A Parish
The Bergman cyclization is an important reaction in which an enediyne cyclizes to produce a highly reactive diradical species, p-benzyne. Enediyne motifs are found in natural antitumor antibiotic compounds, such as calicheammicin and dynemicin. Understanding the energetics of cyclization is required in order to better control the initiation of the cyclization, which induces cell death. We computed the singlet and triplet potential energy surfaces for the Bergman cyclization of (Z)-hex-3-ene-1,5-diyne using the CCSD and EOM-SF-CCSD methods...
December 11, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29227640/raman-spectroscopy-applied-to-parathyroid-tissues-a-new-diagnostic-tool-to-discriminate-normal-tissue-from-adenoma
#14
Andrea Palermo, Marco Fosca, Gaia Tabacco, Federico Marini, Valerio Graziani, Maria Carla Santarsia, Filippo Longo, Angelo Lauria, Roberto Cesareo, Isabella Giovannoni, Chiara Taffon, Massimiliano Rocchia, Silvia Manfrini, Pierfilippo Crucitti, Paolo Pozzilli, Anna Crescenzi, Julietta V Rau
Primary hyperparathyroidism is an endocrine disorder characterized by autonomous production of parathyroid hormone. Patients with the symptomatic disease should be referred for parathyroidectomy. However, the distinction between the pathological condition and the benign one is very challenging in the surgical setting; therefore, accurate recognition is important to ensure success during minimally invasive surgery. At present, all intraoperative techniques significantly increase surgical time and, consequently, cost...
December 11, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29227490/the-role-of-pbi2-in-ch3nh3pbi3-perovskite-stability-solar-cell-parameters-and-device-degradation
#15
Tanaji P Gujar, Thomas Unger, Andreas Schönleber, Martina Fried, Fabian Panzer, Sander van Smaalen, Anna Köhler, Mukundan Thelakkat
We report a systematic investigation on the role of excess PbI2 content in CH3NH3PbI3 perovskite film properties, solar cell parameters and device storage stability. We used the CH3NH3I vapor assisted method for the preparation of PbI2-free CH3NH3PbI3 films under a N2 atmosphere. These pristine CH3NH3PbI3 films were annealed at 165 °C for different time intervals in a N2 atmosphere to generate additional PbI2 in these films. From XRD measurements, the excess of PbI2 was quantified. Detailed characterization using scanning electron microscopy, X-ray diffraction, UV-Visible and photoluminescence for continuous aging of CH3NH3PbI3 films under ambient condition (50% humidity) is carried out for understanding the influence of different PbI2 contents on degradation of the CH3NH3PbI3 films...
December 11, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29227362/comorbidity-of-airway-inflammatory-diseases-in-chemical-and-building-related-intolerance
#16
Anna-Sara Claeson, Hanna Andersson, Fredrik Wikdahl, Maj-Helen Nyback, Steven Nordin
OBJECTIVES: This study investigated comorbidity in chemical intolerance (CI) and building- related intolerance (BRI) with (i) chronic sinusitis, chronic obstructive pulmonary disease, allergic and non-allergic asthma and allergic rhinitis, and (ii) airway inflammatory symptoms. METHODS: Data from two population-based questionnaire surveys, the Västerbotten and Österbotten Environmental Health Studies was used. The participants were categorized as CI or BRI and referents, and binary logistic regression analysis was applied...
December 8, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29227334/quantitative-assessment-of-neuropilin-2-as-a-simple-and-sensitive-diagnostic-assay-for-spitzoid-melanocytic-lesions
#17
Anna Eisenstein, Izabela P Panova, Hye J Chung, Lynne J Goldberg, Qing Zhang, Rossitza Lazova, Jag Bhawan, Klaus J Busam, James T Symanowski, Rhoda M Alani, Byungwoo Ryu
There is a significant need for the development of diagnostic tools that can precisely distinguish Spitz nevi and spitzoid melanomas. Here, we report the development of a PCR-based quantitative diagnostic assay for spitzoid melanocytic lesions utilizing the expression ratio of neuropilin-2 and melan-A genes in primary tumor specimens. We find that the expression ratio of neuropilin-2/melan-A is significantly increased in spitzoid melanomas compared with Spitz nevi. The diagnostic potential of this quantitative assay was validated in two independent sets of patient samples as demonstrated in a receiver operating characteristic curve analysis showing an area under the curve value of 91...
December 8, 2017: Melanoma Research
https://www.readbyqxmd.com/read/29227286/drug-perturbation-based-stratification-of-blood-cancer
#18
Sascha Dietrich, Małgorzata Oleś, Junyan Lu, Leopold Sellner, Simon Anders, Britta Velten, Bian Wu, Jennifer Hüllein, Michelle da Silva Liberio, Tatjana Walther, Lena Wagner, Sophie Rabe, Sonja Ghidelli-Disse, Marcus Bantscheff, Andrzej K Oleś, Mikołaj Słabicki, Andreas Mock, Christopher C Oakes, Shihui Wang, Sina Oppermann, Marina Lukas, Vladislav Kim, Martin Sill, Axel Benner, Anna Jauch, Lesley Ann Sutton, Emma Young, Richard Rosenquist, Xiyang Liu, Alexander Jethwa, Kwang Seok Lee, Joe Lewis, Kerstin Putzker, Christoph Lutz, Davide Rossi, Andriy Mokhir, Thomas Oellerich, Katja Zirlik, Marco Herling, Florence Nguyen-Khac, Christoph Plass, Emma Andersson, Satu Mustjoki, Christof von Kalle, Anthony D Ho, Manfred Hensel, Jan Dürig, Ingo Ringshausen, Marc Zapatka, Wolfgang Huber, Thorsten Zenz
As new generations of targeted therapies emerge and tumor genome sequencing discovers increasingly comprehensive mutation repertoires, the functional relationships of mutations to tumor phenotypes remain largely unknown. Here, we measured ex vivo sensitivity of 246 blood cancers to 63 drugs alongside genome, transcriptome, and DNA methylome analysis to understand determinants of drug response. We assembled a primary blood cancer cell encyclopedia data set that revealed disease-specific sensitivities for each cancer...
December 11, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29226951/cigarette-smoke-and-non-neuronal-cholinergic-system-in-the-airway-epithelium-of-copd-patients
#19
Angela Marina Montalbano, Caterina Di Sano, Giuseppina Chiappara, Loredana Riccobono, Anna Bonanno, Giulia Anzalone, Patrizio Vitulo, Loredana Pipitone, Mark Gjomarkaj, Michael P Pieper, Fabio Luigi Massimo Ricciardolo, Rosalia Paola Gagliardo, Mirella Profita
Acetylcholine (ACh), synthesized by Choline Acetyl-Transferase (ChAT), exerts its physiological effects via mAChRM3 in epithelial cells. We hypothesized that cigarette smoke affects ChAT, ACh, and mAChRM3 expression in the airways from COPD patients promoting airway disease. ChAT, ACh, and mAChRM3 were assessed: "ex vivo" in the epithelium from central and distal airways of COPD patients, Healthy Smoker (S) and Healthy Subjects (C), and "in vitro" in bronchial epithelial cells stimulated with cigarette smoke extract (CSE)...
December 11, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29226848/adsorption-of-triazine-herbicides-from-aqueous-solution-by-functionalized-multiwall-carbon-nanotubes-grown-on-silicon-substrate
#20
Angelo Antonio D'Archivio, Maria Anna Maggi, Antonella Odoardi, Sandro Santucci, Maurizio Passacantando
Multi-walled carbon nanotubes (MWCNTs), because of small size and large available surface area, are potentially efficient sorbents for the extraction of water solutes. Dispersion of MWCNTs in the aqueous medium is suitable to adsorb organic contaminants from small sample volumes, but, the recovery of the suspended sorbent for successive re-use represents a critical step, which makes this method inapplicable in large-scale water-treatment technologies. To overcome this problem, we proposed here MWCNTs grown on silicon supports and investigated on a small-volume scale their adsorption properties towards triazine herbicides dissolved in water...
December 11, 2017: Nanotechnology
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