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Perinatal hiv

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https://www.readbyqxmd.com/read/28534093/quality-of-life-among-perinatally-hiv-affected-and-hiv-unaffected-school-aged-and-adolescent-ugandan-children-a-multi-dimensional-assessment-of-wellbeing-in-the-post-haart-era
#1
A K Nkwata, S K Zalwango, F N Kizza, J N Sekandi, J Mutanga, M Zhang, P M Musoke, A E Ezeamama
OBJECTIVE: To examine quality of life (QOL) in perinatally HIV-infected (PHIV) or HIV-exposed uninfected (PHEU) vs. healthy HIV-unexposed uninfected (HUU) children during school-age/adolescence. METHODS: PHIV infection was diagnosed via DNA PCR. Current HIV status was confirmed by HIV rapid diagnostic test. Three HIV groups were defined: PHIV, PHEU, and HUU. QOL was assessed with proxy and self-report versions of the PedsQL™ 4.0 instrument at 6-18 years of age...
May 22, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28532283/the-feasibility-of-an-automated-eye-tracking-modified-fagan-test-of-memory-for-human-faces-in-younger-ugandan-hiv-exposed-children
#2
Ronak Chhaya, Jonathan Weiss, Victoria Seffren, Alla Sikorskii, Paula M Winke, Julius C Ojuka, Michael J Boivin
OBJECTIVE: The Fagan Test of Infant Intelligence (FTII) uses longer gaze length for unfamiliar versus familiar human faces to gauge visual-spatial encoding, attention, and working memory in infants. Our objective was to establish the feasibility of automated eye tracking with the FTII in HIV-exposed Ugandan infants. METHOD: The FTII was administered to 31 perinatally HIV-exposed noninfected (HEU) Ugandan children 6-12 months of age (11 boys; M = 0.69 years, SD = 0...
May 22, 2017: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://www.readbyqxmd.com/read/28531309/effect-of-antiretroviral-therapy-on-bone-and-renal-health-in-young-adults-infected-with-hiv-in-early-life
#3
Aylin B Unsal, Aviva S Mattingly, Sara E Jones, Julia B Purdy, James C Reynolds, Jeffrey B Kopp, Rohan Hazra, Colleen M Hadigan
Context: HIV antiretroviral (ARV) therapy is associated with renal and bone toxicity, but little is known about the potential cumulative effects in adults exposed to ARVs from birth. Objective: To prospectively evaluate renal and bone health in young adults with lifelong HIV and extensive ARV exposure. Design: Cross-sectional comparison of bone mineral density (BMD by dual-energy X-ray absorptiometry), bone turnover and renal function in young adults infected with HIV in early life (n=65) to matched healthy controls (n=23) and longitudinal evaluation (mean follow-up 4...
May 22, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28530044/a-review-of-transition-experiences-in-perinatally-and-behaviourally-acquired-hiv-1-infection-same-same-but-different
#4
Phung Khanh Lam, Sarah Fidler, Caroline Foster
INTRODUCTION: Despite sharing common psychosocial and developmental experiences, adolescents living with perinatally and behaviourally acquired HIV-1 infection are different in terms of timing of HIV infection and developmental stage at infection. Therefore, it is of interest to identify similarities and differences between these two groups of adolescents living with HIV in their experiences, facilitators and barriers during the transition process. METHODS: A detailed literature search of peer-reviewed published papers was conducted on PubMed to identify relevant original research or viewpoints published up to September 2016...
May 16, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28530042/growing-up-with-perinatal-hiv-changes-in-clinical-outcomes-before-and-after-transfer-to-adult-care-in-the-uk
#5
Ali Judd, Intira Jeannie Collins, Francesca Parrott, Teresa Hill, Sophie Jose, Deborah Ford, Hibo Asad, Diana M Gibb, Caroline Sabin
INTRODUCTION: With improved survival, adolescents with perinatal HIV (PHIV) are transitioning from paediatric to adult care, but there are few published data on clinical outcomes post-transfer. Using linked data from patients in the national UK/Ireland paediatric cohort (CHIPS) and an adult UK cohort of outpatient clinics (UK CHIC), we describe mortality and changes in immunological status post-transfer. METHODS: Participants in CHIPS aged ≥13 years by the end of 2013 were linked to the UK CHIC database...
May 16, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28530040/adolescents-with-hiv-and-transition-to-adult-care-in-the-caribbean-central-america-and-south-america-eastern-europe-and-asia-and-pacific-regions
#6
Heather Bailey, Maria Letícia Santos Cruz, Wipaporn Natalie Songtaweesin, Thanyawee Puthanakit
INTRODUCTION: The HIV epidemics in the Caribbean, Central America and South America (CCASA), Eastern Europe (EE) and Asia and Pacific (AP) regions are diverse epidemics affecting different key populations in predominantly middle-income countries. This narrative review describes the populations of HIV-positive youth approaching adolescence and adulthood in CCASA, EE and AP, what is known of their outcomes in paediatric and adult care to date, ongoing research efforts and future research priorities...
May 16, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28530039/transition-from-paediatric-to-adult-care-of-adolescents-living-with-hiv-in-sub-saharan-africa-challenges-youth-friendly-models-and-outcomes
#7
Désiré Lucien Dahourou, Chloé Gautier-Lafaye, Chloe A Teasdale, Lorna Renner, Marcel Yotebieng, Sophie Desmonde, Samuel Ayaya, Mary-Ann Davies, Valériane Leroy
INTRODUCTION: The number of adolescents with perinatally or behaviourally acquired HIV is increasing in low-income countries, and especially in sub-Saharan Africa where HIV prevalence and incidence are the highest. As they survive into adulthood in the era of antiretroviral therapy, there is a pressing need to transfer them from paediatric to adult care, known as the transition of care. We conducted a narrative review of recent evidence on their transition outcomes in Africa, highlighting the specific needs and challenges in these populations and settings, and the different models of care for transition...
May 16, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28495681/a-comparative-analysis-of-costs-of-single-and-dual-rapid-hiv-and-syphilis-diagnostics-results-from-a-randomised-controlled-trial-in-colombia
#8
Carol Dayo Obure, Hernando Gaitan-Duarte, Ricardo Losada Saenz, Lina Gonzalez, Edith Angel-Muller, Maura Laverty, Freddy Perez
BACKGROUND: HIV and congenital syphilis are major public health burdens contributing to substantial perinatal morbidity and mortality globally. Although studies have reported on the costs and cost-effectiveness of rapid diagnostic tests (RDTs) for syphilis screening within antenatal care in a number of resource-constrained settings, empirical evidence on country-specific cost and estimates of single RDTs compared with dual RDTs for HIV and syphilis are limited. METHODS: A cluster randomised controlled study design was used to compare the incremental costs of two testing algorithms: (1) single RDTs for HIV and syphilis and (2) dual RDTs for HIV and syphilis, in 12 health facilities in Bogota and Cali, Colombia...
May 11, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28492397/post-treatment-control-in-an-adult-with-perinatally-acquired-hiv-following-cessation-of-antiretroviral-therapy
#9
James H McMahon, Judy Chang, Surekha Tennakoon, Ashanti Dantanarayana, Ajantha Solomon, Catherine Cherry, Richard Doherty, Paul Cameron, Sharon R Lewin
No abstract text is available yet for this article.
June 1, 2017: AIDS
https://www.readbyqxmd.com/read/28489732/assessment-of-nevirapine-prophylactic-and-therapeutic-dosing-regimens-for-neonates
#10
Tim R Cressey, Baralee Punyawudho, Sophie Le Coeur, Gonzague Jourdain, Chalermpong Saenjum, Edmund Capparelli, Kanokwan Jittayanun, Siriluk Phanomcheong, Anita Luvira, Thitiporn Borkird, Achara Puangsombat, Leon Aarons, Pra-Ornsuda Sukrakanchana, Saik Urien, Marc Lallemant
BACKGROUND: Nevirapine (NVP) is a key component of antiretroviral prophylaxis and treatment for neonates. We evaluated current WHO weight-band NVP prophylactic dosing recommendations and investigated optimal therapeutic NVP dosing for neonates. METHODS: The PHPT-5 study in Thailand assessed the efficacy of 'Perinatal Antiretroviral Intensification' to prevent mother-to-child transmission of HIV in women with <8 weeks of antiretroviral treatment before delivery (NCT01511237)...
May 9, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28489226/transition-of-care-for-youth-with-hiv
#11
Mary Ellen Acree
Remarkable advances have been made in the treatment of HIV. Despite progress in reducing perinatal HIV transmission, there is a growing number of adolescents and emerging adults with HIV who will require transfer of care from pediatric to adult providers. Adolescents with HIV have poorer retention in care and viral suppression compared to other age groups with HIV. Barriers to successful care of youth with HIV include mental health disorders, poor medication adherence, socioeconomic instability, and HIV-related stigma...
May 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/28482821/understanding-coping-strategies-during-pregnancy-and-the-postpartum-period-a-qualitative-study-of-women-living-with-hiv-in-rural-uganda
#12
Scholastic Ashaba, Angela Kaida, Bridget Frances Burns, Kasey O'Neil, Emma Dunkley, Christina Psaros, Jasmine Kastner, Alexander C Tsai, David R Bangsberg, Lynn T Matthews
BACKGROUND: In sub-Saharan Africa, 58% of adults living with HIV are women. In Uganda, HIV prevalence is 8.3% for women compared to 6.1% for men. Access to antiretroviral therapy (ART) and prevention of mother to child transmission (PMTCT) programs have enabled women living with HIV (WLWH) to have children with minimal risk of perinatal transmission. Nevertheless, pregnant WLWH face many challenges. We explored women's perceptions of how they cope with the challenges of pregnancy and the postpartum period as HIV-infected women...
May 8, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28482682/longitudinal-development-of-cognitive-visuomotor-and-adaptive-behavior-skills-in-hiv-uninfected-children-aged-3-5-years-of-age-exposed-pre-and-perinatally-to-anti-retroviral-medications
#13
Mary Lou Smith, Klajdi Puka, Ramandeep Sehra, Stanley E Read, Ari Bitnun
Little is known about the neurodevelopmental outcomes of children older than 3 years of age born to HIV infected mother but who are HIV-uninfected (HEU), and who have been exposed in utero and early in life to HIV and to antiretroviral medications (ARVs). We conducted a longitudinal study of cognitive, visuomotor and adaptive function of HEU children, who were assessed at two ages, 3.5 and 5.5 years. Sixty-four children (33 female) were assessed. In comparison with population norms for their age, at 3.5 years of age they had scores significantly below age expectations on aspects of adaptive behavior, but at age 5...
May 8, 2017: AIDS Care
https://www.readbyqxmd.com/read/28481997/patterns-of-growth-body-composition-and-lipid-profiles-in-a-south-african-cohort-of-human-immunodeficiency-virus-infected-and-uninfected-children-a-cross-sectional-study
#14
Sarah M Ramteke, Stephanie Shiau, Marc Foca, Renate Strehlau, Francoise Pinillos, Faeezah Patel, Avy Violari, Afaaf Liberty, Ashraf Coovadia, Louise Kuhn, Stephen M Arpadi
Background.: Prior research in sub-Saharan Africa reports dyslipidemia in perinatally human immunodeficiency virus (HIV)-infected children receiving ritonavir-boosted lopinavir (LPV/r) compared with efavirenz; however, interpretation of findings is limited by lack of comparison data from HIV-uninfected children. Methods.: We conducted a cross-sectional analysis of lipid profiles and growth within a larger longitudinal cohort study of perinatally HIV-infected and HIV-uninfected children aged 4-9 years in Johannesburg, South Africa...
May 6, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28481783/impact-of-perinatally-acquired-hiv-disease-upon-longitudinal-changes-in-memory-and-executive-functioning
#15
Kathleen M Malee, Miriam C Chernoff, Patricia A Sirois, Paige L Williams, Patricia A Garvie, Betsy L Kammerer, Lynnette L Harris, Molly L Nozyce, Cenk Yildirim, Sharon L Nichols
BACKGROUND: Little is known regarding effects of perinatally-acquired HIV infection (PHIV) on longitudinal change in memory and executive functioning (EF) during adolescence, despite the importance of these skills for independence in adulthood. METHODS: PHIV (n=144) and perinatally HIV-exposed uninfected youth (PHEU, n=79), ages 12-17, completed standardized tests of memory and EF at baseline and two years later. Changes from baseline for each memory and EF outcome were compared between PHEU and PHIV youth with (PHIV/C, n=39) and without (PHIV/non-C, n=105) history of CDC Class C (AIDS-defining) diagnoses...
May 5, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28481770/elective-cesarean-section-for-women-living-with-hiv-a-systematic-review-of-risks-and-benefits
#16
Caitlin E Kennedy, Ping Teresa Yeh, Shristi Pandey, Ana Pilar Betran, Manjulaa Narasimhan
OBJECTIVE AND DESIGN: To inform World Health Organization guidelines, we conducted a systematic review and meta-analysis to assess maternal and perinatal outcomes comparing cesarean section before labor and rupture of membranes (elective c-section/ECS) with other modes of delivery for women living with HIV. METHODS: We searched PUBMED, CINAHL, Embase, CENTRAL, and previous reviews to identify published trials and observational studies through October 2015. Results were synthesized using random-effects meta-analysis, stratifying for combination antiretroviral therapy (cART), CD4/viral load (VL), delivery at term, and low-/middle-income countries (LMICs)...
May 5, 2017: AIDS
https://www.readbyqxmd.com/read/28480253/premature-coronary-artery-disease-and-st-elevation-myocardial-infarction-in-a-24-year-old-man-with-perinatally-acquired-human-immunodeficiency-virus-a-case-report
#17
David C Griffith, Konstantinos N Aronis, Angela M Orozco, Thomas A Traill, Yukari C Manabe, Allison L Agwu
Patients with human immunodeficiency virus (HIV) have increased risk of cardiovascular disease. Although evidence of subclinical atherosclerosis in perinatally acquired HIV (PHIV) is available, myocardial infarction has not been described in this population. We report a case of myocardial infarction in a patient with PHIV with a brief literature review.
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28480237/gag-specific-cd8-t-cell-proliferation-is-associated-with-higher-peripheral-blood-levels-of-transforming-growth-factor-%C3%AE-and-gut-homing-t-cells-in-youths-perinatally-infected-with-human-immunodeficiency-virus-1-the-anrs-ep38-immip-study
#18
Josiane Warszawski, Véronique Avettand-Fenoel, Christine Rouzioux, Daniel Scott-Algara, Thomas Montange, Céline Didier, Jérôme Le Chenadec, Jean-Paul Viard, Catherine Dollfus, Stéphane Blanche, Florence Buseyne
BACKGROUND: Gag-specific T lymphocytes play a key role in the control of human immunodeficiency virus (HIV) replication. Their restoration will be important for future reservoir targeting strategies. In this study, we aimed to identify immune correlates of Gag-specific CD8 T-cell proliferation in youths with perinatally acquired HIV-1 infection. METHODS: The ANRS-EP38-IMMIP study included youths of 15 to 24 years of age. Fifty-three were taking combination anti-retroviral therapy and aviremic at the time of the study and had undergone valid 5-6-carboxyfluorescein diacetate succimidyl ester-based flow cytometry T-cell proliferation assays...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28462680/does-placental-mdsc-mediated-modulation-of-arginine-levels-help-protect-the-foetus-from-auxotrophic-pathogens
#19
Abdul Qader Tahir Ismail
Myeloid-derived suppressor cells (MDSCs) are immunosuppressive precursors of dendritic cells, macrophages and granulocytes. MDSCs normally quickly differentiate, but have elevated levels in chronic infection and cancer, where they help tumours evade the immune system through induction of T-cell dysfunction. MDSC levels are also raised in pregnancy, and in the neonate. During pregnancy they may help to prevent maternal rejection of the semiallogenic foetus. In the immediate postnatal period they may aid in allowing tolerance of gut microbiological colonisation and non-pathological environmental antigens...
May 2, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28459866/psychosocial-challenges-facing-women-living-with-hiv-during-the-perinatal-period-in-rural-uganda
#20
Scholastic Ashaba, Angela Kaida, Jessica N Coleman, Bridget F Burns, Emma Dunkley, Kasey O'Neil, Jasmine Kastner, Naomi Sanyu, Cecilia Akatukwasa, David R Bangsberg, Lynn T Matthews, Christina Psaros
The complexities of navigating pregnancy while living with HIV predispose women to additional stress. Finding ways to minimize psychosocial challenges during the perinatal period may maximize the well-being of mothers living with HIV and their children. The goal of this study was to explore psychosocial challenges experienced by women living with HIV (WLWH) during pregnancy and the postpartum. We conducted individual in-depth interviews with 20 WLWH recruited from an HIV treatment cohort study in Mbarara, Uganda as part of a larger study exploring perinatal depression...
2017: PloS One
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