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Human herpesvirus 6

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https://www.readbyqxmd.com/read/29316040/herpesviruses-viral-loads-and-levels-of-proinflammatory-cytokines-in-apical-periodontitis
#1
Aleksandar Jakovljevic, Aleksandra Knezevic, Nadja Nikolić, Ivan Soldatović, Tanja Jovanovic, Jelena Milasin, Miroslav Andric
OBJECTIVES: This study aimed to analyse Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) viral loads in symptomatic and asymptomatic apical periodontitis lesions, to determine levels of TNF-α, IL-1β, and IL-6 in these lesions and to investigate a possible correlation between herpesviral copy numbers and levels of proinflammatory cytokines . MATERIALS AND METHODS: 100 samples of apical periodontitis were subjected to HCMV and EBV copy numbers analysis by nested polymerase chain reaction (PCR) and TaqMan real-time PCR...
January 9, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29307291/viruses-in-chronic-progressive-neurologic-disease
#2
Emily C Leibovitch, Steven Jacobson
Viruses have long been implicated as triggers of disease onset and progression in multiple sclerosis (MS) and similar neuroinflammatory disorders. Decades of epidemiological, molecular, and pathologic studies have most strongly linked the human herpesviruses Epstein-Barr virus (EBV) and human herpesvirus 6 (HHV-6) with MS. However, these viruses are ubiquitous in the general population and typically acquired decades before disease presentation, complicating the study of how they might contribute to disease...
January 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29304865/evaluation-of-a-method-to-measure-hhv-6b-infection-in%C3%A2-vitro-based-on-cell-size
#3
Aniuska Becerra-Artiles, Tessa Santoro, Lawrence J Stern
BACKGROUND: Human herpesvirus 6 (HHV-6A and HHV-6B) infection of cell cultures can be measured by different methods, including immunofluorescence microscopy, flow cytometry, or quantification of virus DNA by qPCR. These methods are reliable and sensitive but require long processing times and can be costly. Another method used in the field relies on the identification of enlarged cells in the culture; this method requires little sample processing and is relatively fast. However, visual inspection of cell cultures can be subjective and it can be difficult to establish clear criteria to decide if a cell is enlarged...
January 5, 2018: Virology Journal
https://www.readbyqxmd.com/read/29297965/the-impact-of-alternative-donor-types-on-viral-infections-in-pediatric-hematopoietic-stem-cell-transplantation
#4
D Atay, A Akcay, F Erbey, G Ozturk
Viral infections remain one of the most important complications following allogeneic HSCT. Few reports compare virus infection between different donor types in pediatric patients. We retrospectively analyzed viral infections and the outcome of one hundred and seventy-one pediatric patients (median 7.38 years) who underwent allogeneic HSCT from matched related donor (MRD, n = 71), 10 of 10 HLA allele-matched unrelated donors (MUD1; n = 29), 9 of 10 HLA allele-matched unrelated donors (MUD2; n = 40), and haploidentical donors (n = 31)...
January 3, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29239890/omega-3-decreases-interleukin-6-levels-in-hiv-and-hhv-8-co-infected-patients-results-from-a-randomized-supplementation-trial-in-uganda
#5
Anna E Coghill, Jeanette M Schenk, Zeina Mahkoul, Jackson Orem, Warren Phipps, Corey Casper
OBJECTIVE: Kaposi sarcoma (KS) is an HIV-associated malignancy caused by human herpesvirus-8 that occurs at highest incidence in sub-Saharan Africa. KS patients often present with inflammatory symptoms associated with higher mortality. DESIGN: We conducted a double-blind, randomized, placebo-controlled study in Uganda to test whether omega-3 (ω-3) supplementation could reduce inflammation in HIV and HHV-8 co-infected adults ≥ 18 years of age. Patients with acute illness, AIDS, or advanced KS were ineligible, as were pregnant women...
December 12, 2017: AIDS
https://www.readbyqxmd.com/read/29206935/report-of-a-myocarditis-outbreak-among-pediatric-patients-human-herpesvirus-7-as-a-causative-agent
#6
Rahmi Ozdemir, Mehmet Kucuk, Saime Ergen Dibeklioglu
Background: The etiology of myocarditis in children has not yet been completely elucidated. Objective: Medical records of eight pediatric patients diagnosed with acute myocarditis within a 41-day period in a small-town hospital were retrospectively analyzed. Methods: We examined antibody titers of adenovirus, Epstein-Barr virus, herpes simplex virus, respiratory syncytial virus, varicella-zoster virus and cytomegalovirus in peripheral blood...
November 30, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29194419/the-interplay-between-natural-killer-cells-and-human-herpesvirus-6
#7
REVIEW
Eva Eliassen, Dario Di Luca, Roberta Rizzo, Isabel Barao
Human Herpesvirus 6 (HHV-6) is a set of two closely related herpes viruses known as HHV-6A and HHV-6B. Both are lymphotropic viruses that establish latency in the host. The ability to evade the immune responses of effector cells is likely a major factor contributing to the development of a persistent HHV-6A/B (collectively termed HHV-6) infection. Natural killer (NK) cells are lymphocytes that, along with neutrophils and monocytes/macrophages, participate in the critical innate immune response during viral infections, but can also mediate the antigen-specific memory responses generally associated with adaptive immunity...
December 1, 2017: Viruses
https://www.readbyqxmd.com/read/29191994/correction-for-cousins-and-nicholas-role-of-human-herpesvirus-8-interleukin-6-activated-gp130-signal-transducer-in-primary-effusion-lymphoma-cell-growth-and-viability
#8
Emily Cousins, John Nicholas
No abstract text is available yet for this article.
December 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29184003/il-10-promoter-transactivation-by-the-viral-k-rta-protein-involves-the-host-cell-transcription-factors-specificity-protein-1-and-3
#9
Masanori Miyazawa, Kohji Noguchi, Mana Kujirai, Kazuhiro Katayama, Satoshi Yamagoe, Yoshikazu Sugimoto
Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus-8 (HHV-8) causes a persistent infection, presenting latent and lytic replication phases during its life cycle. KSHV-related diseases are associated with deregulated expression of inflammatory cytokines, including IL-6 and IL-10, but the mechanisms underlying this dysregulation are unclear. Herein, we report a molecular mechanism for KSHV-induced IL-10 gene expression. KSHV replication and transcription activator (K-RTA) is a molecular switch for the initiation of expression of viral lytic genes, and we describe, for the first time, that K-RTA significantly activates the promoter of the human IL-10 gene...
November 28, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29181879/high-human-herpesvirus-6-viral-load-in-pediatric-allogeneic-hematopoietic-stem-cell-transplant-patients-is-associated-with-detection-in-end-organs-and-high-mortality
#10
Lena E Winestone, Rajesh Punn, John S Tamaresis, Julia Buckingham, Benjamin A Pinsky, Jesse J Waggoner, Sandhya Kharbanda
Human Herpes Virus 6 (HHV-6) reactivation occurs in approximately half of patients following allogeneic hematopoietic stem cell transplant (HSCT). While encephalitis and delayed engraftment are well-documented complications of HHV-6 following HSCT, the extent to which HHV-6 viremia causes disease in children is controversial. We performed a retrospective review of HHV-6 reactivation and possible manifestations in pediatric allogeneic HSCT patients at a single institution. Of 89 children and young adults who underwent allogeneic HSCT over a three-and-a-half-year period, 34 patients reactivated HHV-6 early post-transplant...
November 27, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/29178248/no-indication-of-increased-infection-rates-using-low-dose-alemtuzumab-instead-of-anti-thymocyte-globulin-as-graft-versus-host-disease-prophylaxis-before-allogeneic-stem-cell-transplantation
#11
Thomas Neumann, Laila Schneidewind, Thomas Thiele, Daniel Pink, Meike Schulze, Christian Schmidt, William Krüger
BACKGROUND: Alemtuzumab as part of the conditioning protocol is effective in reducing graft-versus-host disease (GvHD), but may be associated with increased infection rates, especially when using high doses (ie, 100 mg). METHODS: We performed a retrospective, single-centre, case-control study analysing the rates of neutropenic fever, cytomegalovirus (CMV) reactivation, Epstein-Barr virus (EBV) reactivation, clinical manifest toxoplasmosis, and clinical manifest human herpesvirus-6 (HHV6) infection using low-dose alemtuzumab in comparison with anti-thymocyte globulin (ATG) as GvHD prophylaxis before allogeneic stem cell transplantation...
November 27, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29169653/-how-i-manage-ebv-reactivation-and-ebv-ptld-cmv-and-human-herpesvirus%C3%A2-6%C3%A2-reactivation-and-infection-after-allogeneic-stem-cell-transplantation-a-report-of-the-sfgm-tc-update
#12
REVIEW
Eolia Brissot, Tamim Alsuliman, Bérengère Gruson, Eric Hermet, Yordanka Tirefort, Ibrahim Yakoub-Agha, Sophie Alain
The French society of bone marrow transplantation and cell therapy (SFGM-TC) organizes annually workshops in the attempt to harmonize clinical practices between different francophone transplantation center. Here, we report our recommendations regarding the management of Epstein Barr virus reactivation and lymphoproliferative disorders, cytomegalovirus (CMV) and human herpes virus 6 (HHV6) after allogeneic stem cell transplantation.
November 20, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/29163428/hhv-6a-6b-infection-of-nk-cells-modulates-the-expression-of-mirnas-and-transcription-factors-potentially-associated-to-impaired-nk-activity
#13
Roberta Rizzo, Irene Soffritti, Maria D'Accolti, Daria Bortolotti, Dario Di Luca, Elisabetta Caselli
Natural killer (NK) cells have a critical role in controlling virus infections, and viruses have evolved several mechanisms to escape NK cell functions. In particular, Human herpesvirus 6 (HHV-6) is associated with diseases characterized by immune dysregulation and has been reported to infect NK cells. We recently found that HHV-6 in vitro infection of human thyroid follicular epithelial cells and T-lymphocytes modulates several miRNAs associated with alterations in immune response. Since miRNAs are key regulators of many immune pathways, including NK cell functions, we aimed to study the impact of HHV-6A and -6B in vitro infection on the intracellular mediators correlated to NK cell function...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29157621/treatment-of-kaposi-sarcoma-herpesvirus-associated-multicentric-castleman-disease
#14
REVIEW
Kathryn Lurain, Robert Yarchoan, Thomas S Uldrick
Kaposi sarcoma herpesvirus (KSHV)-associated multicentric Castleman disease (MCD) is a rare, polyclonal lymphoproliferative disorder characterized by flares of inflammatory symptoms, edema, cytopenias, lymphadenopathy, and splenomegaly. Diagnosis requires a lymph node biopsy. Pathogenesis is related to dysregulated inflammatory cytokines, including human and viral interleukin-6. Rituximab alone or in combination with chemotherapy, such as liposomal doxorubicin, has led to an overall survival of over 90% at 5 years...
February 2018: Hematology/oncology Clinics of North America
https://www.readbyqxmd.com/read/29156094/multiple-transmissions-of-chromosomally-integrated-human-herpesvirus-6-in-one-family
#15
Armin Rashidi, Karam Obeid, Joshua Hill, Erica D Warlick, Daniel J Weisdorf
Chromosomally integrated human herpesvirus-6 (ciHHV-6) can be transmitted from parent to child or via allogeneic hematopoietic cell transplantation (HCT). We report a case of ciHHV-6 transmitted via syngeneic HCT, and vertically across three generations. ciHHV-6 was transmitted from a parent to the patient and her identical twin, and from the patient to her son. The patient underwent syngeneic HCT as rescue from chemotherapy-induced aplasia during which ciHHV-6 was re-transmitted to her, this time from her identical twin...
November 20, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29143761/antibody-cross-reactivity-between-porcine-cytomegalovirus-pcmv-and-human-herpesvirus-6-hhv-6
#16
Uwe Fiebig, Angela Holzer, Daniel Ivanusic, Elena Plotzki, Hartmut Hengel, Frank Neipel, Joachim Denner
Porcine cytomegalovirus (PCMV) infection is widely prevalent among pigs, and PCMV is one of the viruses which may be transmitted during xenotransplantation using pig cells, tissues, or organs. While human cytomegalovirus (HCMV) is a major risk factor for allotransplantation, it is still unclear whether PCMV is able to infect human cells or pose a risk for xenotransplantation. Previously, it was shown that transmission of PCMV after pig kidney to non-human primate transplantations resulted in a significantly reduced survival time of the transplanted organ...
October 28, 2017: Viruses
https://www.readbyqxmd.com/read/29138334/correction-for-cousins-et-al-human-herpesvirus-8-viral-interleukin-6-signaling-through-gp130-promotes-virus-replication-in-primary-effusion-lymphoma-and-endothelial-cells
#17
Emily Cousins, Yang Gao, Gordon Sandford, John Nicholas
No abstract text is available yet for this article.
December 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29091300/serologic-and-viral-genome-prevalence-of-hsv-ebv-and-hcmv-among-healthy-adults-in-wuhan-china
#18
Le Wen, Yong Qiu, Shuang Cheng, Xuan Jiang, Yan-Ping Ma, Wei Fang, Wei Wang, Jie Cui, Qiang Ruan, Fei Zhao, Fei Hu, Min-Hua Luo
The worldwide infection rate of herpesvirus is high, but the detailed prevalence in China, especially the central area, remains unclear. In the present study, the prevalence of Herpes simplex virus (HSV), Epstein-Barr virus (EBV), and human cytomegalovirus (HCMV) was investigated in 303 healthy adults in Wuhan, a representative city in Central China. Viral specific IgG and IgM titers were examined in the serum by chemiluminescent immunoassay, and the existence of viral genomic DNA in blood cells were determined by nested PCR...
November 1, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/29081916/prospective-study-of-human-herpesvirus-8-oral-shedding-viremia-and-serological-status-among-human-immunodeficiency-virus-seropositive-and-seronegative-individuals-in-sao-paulo-brazil
#19
Paulo H Braz-Silva, Tania R Tozetto-Mendoza, Laura M Sumita, Wilton Freire, Michelle Palmieri, Alan M do Canto, Vivian I Avelino-Silva, Marina Gallottini, Philippe Mayaud, Claudio S Pannuti
Human herpesvirus 8 (HHV-8) is a gamma-herpesvirus and etiological agent of all forms of Kaposi sarcoma (KS). Saliva may play an important role in HHV-8 transmission in specific populations. Little is known about HHV-8 oral shedding pattern and the possible correlation with the HHV-8 serological profile and viremia. A prospective study was conducted of HHV-8 salivary excretion among human immunodeficiency virus HIV-seronegative (n = 47) and -seropositive (n = 44) homosexual men and HIV-seropositive women (n = 32) over a 6-month period with monthly HHV-8 serologies (immunofluorescence assays to identify antibodies to latent and lytic HHV-8 viral proteins, and a whole-virus HHV-8 enzyme-linked immunosorbent assay [ELISA]), monthly HHV-8 DNA serum/plasma detection, and daily self-collected oral rinses for HHV-8-DNA detection using real-time polymerase chain reaction...
2017: Journal of Oral Microbiology
https://www.readbyqxmd.com/read/29064795/the-impact-of-emergent-infections-on-the-fetal-state
#20
Liudmyla A Vygivska, Iryna O Tuchkina, Violetta B Kalnytska
THE AIM: To study the impact of emergent infections (human herpesvirus type 6) on the fetal state. MATERIALS AND METHODS: The study involved examination of 90 pregnant women in the 2nd and 3rd trimesters of gestation (Group 1 (25 pregnant) consisted of patients with a viral infection, CMV carriers, Group 2 (25 pregnant) included women with a viral infection, herpes simplex virus types 1/2, Group 3 amounted for 20 patients with a viral infection, herpes simplex virus type 6, Group 4 comprised 20 patients with normal pregnancy and no signs of infection...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
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