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Human herpesvirus 6

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https://www.readbyqxmd.com/read/27881138/bohv-4-based-vector-delivering-ebola-virus-surface-glycoprotein
#1
Alfonso Rosamilia, Sarah Jacca, Giulia Tebaldi, Silvia Tiberti, Valentina Franceschi, Francesca Macchi, Sandro Cavirani, Gary Kobinger, Donald P Knowles, Gaetano Donofrio
BACKGROUND: Ebola virus (EBOV) is a Category A pathogen that is a member of Filoviridae family that causes hemorrhagic fever in humans and non-human primates. Unpredictable and devastating outbreaks of disease have recently occurred in Africa and current immunoprophylaxis and therapies are limited. The main limitation of working with pathogens like EBOV is the need for costly containment. To potentiate further and wider opportunity for EBOV prophylactics and therapies development, innovative approaches are necessary...
November 24, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27862208/the-cytokines-and-cellular-responses-to-human-herpesvirus-6b-in-patients-with-b-acute-lymphoblastic-leukemia
#2
Faten Nefzi, Claude Lambert, Agnès Gautheret-Dejean, Sylvain Fisson, Quentin Khebizi, Abderrahim Khelif, Henri Agut, Mahjoub Aouni
Human herpesvirus-6 (HHV-6) is a β-herpesvirus with primary infection followed by its lifelong persistence in its host. The T-cell responses to HHV-6 mostly have been characterized using peripheral blood from healthy adults. Although the role of HHV-6 infection in immune modulation in some of the diseases was not elucidated. Therefore, we analyzed the immune response to HHV-6 infection in B-acute lymphobastic leukemia (B-ALL) patients. HHV-6 load was quantified in blood samples at the time of diagnosis of leukemia and at remission...
November 15, 2016: Microbiology and Immunology
https://www.readbyqxmd.com/read/27859994/transmission-of-chromosomally-integrated-human-herpesvirus-6-via-cord-blood-transplantation
#3
Yuji Yamada, Tomoo Osumi, Ken-Ichi Imadome, Etsuko Takahashi, Tamae Ohye, Tetsushi Yoshikawa, Daisuke Tomizawa, Motohiro Kato, Kimikazu Matsumoto
Chromosomally integrated human herpesvirus 6 (ciHHV-6) can be transmitted via allogeneic hematopoietic cell transplantation. To date, only a few cases have been reported. Here, we report a case identified as transmission of ciHHV-6 via cord blood transplantation. Distinguishing transmission of ciHHV-6 from HHV-6 reactivation in cases with high titer of HHV-6 DNA load after transplantation is important to prevent unnecessary exposure to antiviral drugs which could be toxic. This article is protected by copyright...
November 16, 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/27837274/regulation-of-the-viral-life-cycle-by-murine-gammaherpesvirus-68-micrornas
#4
Soowon Kang, Chanoh Jeon, Kyungtaek Im, Moon Jung Song, Hyeyoung Min
γ-Herpesviruses (γHV) such as Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus are important human pathogens involved in lymphoproliferation and tumorigenesis. Murine gammaherpesvirus 68 (MHV-68, γHV-68) is an effective model for the study of γHV pathogenesis and host-virus interaction because it is closely related to human γHV. Similarly to human γHV, MHV-68 encodes 15 microRNAs (miRNAs). Although their functions remain unknown, they are thought to regulate the viral life cycle or host-virus interactions, similarly to other human γHV...
November 11, 2016: Archives of Virology
https://www.readbyqxmd.com/read/27800078/-molecular-tests-in-diagnosis-of-cytomegalovirus-cmv-human-herpesvirus-6-hhv-6-and-epstein-barr-virus-ebv-using-real-time-pcr-in-hiv-positive-and-hiv-negative-pregnant-women-in-ouagadougou-burkina-faso
#5
Alice Rogomenoma Ouedraogo, Madeleine Kabre, Cyrille Bisseye, Théodora Mahoukèdè Zohoncon, Maleki Asshi, Serge Théophile Soubeiga, Birama Diarra, Lassina Traore, Florencia Wendkuuni Djigma, Djénéba Ouermi, Virginio Pietra, Nicolas Barro, Jacques Simpore
INTRODUCTION: Herpesvirus EBV, CMV and HHV-6 are viruses that evolve based on pandemic modeling and are responsible for congenital infections causing severe sequelae in infants. This study aims to determine the prevalence of CMV, EBV and HHV-6 among HIV (+) and HIV (-) pregnant women in Ouagadougou. METHODS: In this study 200 blood plasma samples taken from pregnant women, of whom 100 with HIV(+) and 100 with HIV(-), were analyzed using multiplex real-time PCR which detected three infections (EBV, CMV and HHV-6)...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27795414/identification-of-novel-kshv-orf50-transcripts-discovery-of-new-rta-isoforms-with-variable-transactivation-potential
#6
Brian S Wakeman, Yoshihiro Izumiya, Samuel H Speck
: Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus that has been associated with primary effusion lymphoma, multicentric Castleman's disease, as well as its namesake Kaposi's sarcoma. As a gammaherpesvirus, KSHV is able to acutely replicate, enter latency, and reactivate from this latent state. A key protein involved in both acute replication and reactivation from latency is the replication and transcriptional activator (RTA) encoded by the gene Orf50. RTA is a known transactivator of multiple viral genes allowing for it to control the switch between latency and virus replication...
October 19, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27777240/inherited-chromosomally-integrated-human-herpesvirus-6-and-breast-cancer
#7
Annie Gravel, Isabelle Dubuc, Angela Brooks-Wilson, Kristan J Aronson, Jacques Simard, Hector Velasquez-Garcia, John J Spinelli, Louis Flamand
Background Inherited chromosomally-integrated human herpesvirus 6 (iciHHV-6) is a condition observed in approximately 1% of the population. Whether such a genetic alteration predisposes to cancer development in currently unknown. Two studies were conducted to determine whether iciHHV-6 is associated with cancer development. Methods First, a screen of 19,597 people from the province of Quebec was conducted. A replication test, using data from a population-based case-control study of 1090 women with incident breast cancer and 1053 controls from British Columbia and Ontario was conducted...
October 24, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27772620/cytomegalovirus-and-other-%C3%AE-herpesviruses
#8
Carlos A Q Santos
Cytomegalovirus (CMV), human herpes virus (HHV)-6, and HHV-7 are ubiquitous β-herpesviruses that can cause opportunistic infection and disease in kidney transplant recipients. Active CMV infection and disease are associated with acute allograft failure and death, and HHV-6 and HHV-7 replication are associated with CMV disease. CMV prevention strategies are used commonly after kidney transplantation, and include prophylaxis with antiviral medications and preemptive treatment upon the detection of asymptomatic viral replication in blood...
September 2016: Seminars in Nephrology
https://www.readbyqxmd.com/read/27703035/cd4-t-cells-co-expressing-cd134-ox40-harbor-significantly-increased-levels-of-hhv-6b-dna-following-umbilical-cord-blood-transplantation
#9
Joshua C Pritchett, Jaime S Green, Angela M Thomm, Konstance K Knox, Michael R Verneris, Troy C Lund
Human herpesvirus-6B (HHV-6B) commonly reactivates after umbilical cord blood transplant (UCBT) and is associated with delayed engraftment, fever, rash, and CNS dysfunction. Recently CD134 (OX40) has been implicated as a potential viral entry receptor. We evaluated CD4(+)CD134(+)/(neg-lo) and CD8(+) CD134(+)/(neg-lo) cells at day +28 after UCBT in 20 subjects with previously documented HHV-6 reactivation and persistent viremia. Analysis of CD4(+)CD134(+) cells compared to CD4(+)CD134(neg-lo) cells showed 0...
October 4, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27702550/modulation-of-cytotoxic-responses-by-targeting-cd160-prolongs-skin-graft-survival-across-major-histocompatibility-class-i-barrier
#10
Maria-Luisa Del Rio, Ana Maria Bravo Moral, Carlos Fernandez-Renedo, Leo Buhler, Jose-Antonio Perez-Simon, Olivier Chaloin, Rafael Alvarez Nogal, Maximino Fernandez-Caso, Jose-Ignacio Rodriguez-Barbosa
CD160 is a glycosylphosphatidylinositol-anchored protein of the immunoglobulin superfamily. It exhibits a pattern of expression coincident in humans and mice that is mainly restricted to cytotoxic cells and to all intestinal intraepithelial T lymphocytes. B- and T-lymphocyte attenuator (BTLA) and CD160 interact with cysteine-rich domain 1 of the extracellular region of Herpesvirus entry mediator (HVEM). CD160 engagement by HVEM can deliver inhibitory signals to a small subset of human CD4 T cells and attenuate its proliferation and cytokine secretion, but can also costimulate natural killer cells or intraepithelial lymphocytes...
September 15, 2016: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/27694307/distribution-and-effects-of-amino-acid-changes-in-drug-resistant-%C3%AE-and-%C3%AE-herpesviruses-dna-polymerase
#11
D Topalis, S Gillemot, R Snoeck, G Andrei
Emergence of drug-resistance to all FDA-approved antiherpesvirus agents is an increasing concern in immunocompromised patients. Herpesvirus DNA polymerase (DNApol) is currently the target of nucleos(t)ide analogue-based therapy. Mutations in DNApol that confer resistance arose in immunocompromised patients infected with herpes simplex virus 1 (HSV-1) and human cytomegalovirus (HCMV), and to lesser extent in herpes simplex virus 2 (HSV-2), varicella zoster virus (VZV) and human herpesvirus 6 (HHV-6). In this review, we present distinct drug-resistant mutational profiles of herpesvirus DNApol...
November 16, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27693656/association-of-active-human-herpesvirus-6-hhv-6-infection-with-autoimmune-thyroid-gland-diseases
#12
Alina Sultanova, Maksims Cistjakovs, Sabine Gravelsina, Svetlana Chapenko, Silvija Roga, Egils Cunskis, Zaiga Nora-Krukle, Valerija Groma, Ildze Ventina, Modra Murovska
OBJECTIVES: Viral infections have been frequently cited as important environmental factors implicated in the onset of autoimmune thyroiditis (AIT). The aim of this study was to determine the involvement of HHV-6 infection in the development of autoimmune thyroiditis. METHODS: This study included 45 patients (42 female and 3 male; median age 47.00 IQR: 38.50-57.00) with histologically, laboratory and clinically confirmed autoimmune thyroiditis, as well as 30 autopsied subjects (26 women and 4 men; median age 58...
September 29, 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27669362/human-herpesvirus-6-replication-predicts-cytomegalovirus-reactivation-after-allogeneic-stem-cell-transplantation-from-haploidentical-donor
#13
Roberto Crocchiolo, Laura Giordano, Andrea Rimondo, Muriel Bologna, Barbara Sarina, Lucio Morabito, Stefania Bramanti, Luca Castagna, Rossana Mineri
BACKGROUND AND OBJECTIVES: Since HHV-6 reactivation after transplant has been reported to increase the risk of CMV infection, we tested this hypothesis in the HLA-haploidentical hematopoietic stem cell transplantation setting. STUDY DESIGN: From February 2011 to October 2015, 75 patients received hematopoietic stem cell transplantation using a T-cell replete graft from a HLA-haploidentical donor at our Institution. RESULTS: Interestingly, 87% of HHV-6 reactivations were followed by a CMV reactivation, at a median of 15days between the two viruses...
September 20, 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27664550/central-nervous-system-infection-following-allogeneic-hematopoietic-stem-cell-transplantation
#14
Ryo Hanajiri, Takeshi Kobayashi, Kosuke Yoshioka, Daisuke Watanabe, Kyoko Watakabe, Yutaka Murata, Takeshi Hagino, Yasushi Seno, Yuho Najima, Aiko Igarashi, Noriko Doki, Kazuhiko Kakihana, Hisashi Sakamaki, Kazuteru Ohashi
OBJECTIVE/BACKGROUND: Here, we described the clinical characteristics and outcomes of central nervous system (CNS) infections occurring after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in a single institution over the previous 6 years. METHODS: Charts of 353 consecutive allogeneic transplant recipients were retrospectively reviewed for CNS infection. RESULTS: A total of 17 cases of CNS infection were identified at a median of 38 days (range, 10-1028 days) after allo-HSCT...
September 17, 2016: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/27662501/kaposi-sarcoma-herpesvirus-associated-cancers-and-related-diseases
#15
Priscila H Goncalves, Joseph Ziegelbauer, Thomas S Uldrick, Robert Yarchoan
PURPOSE OF REVIEW: This review discusses the pathogenesis and recent advances in the management of Kaposi sarcoma herpesvirus (KSHV)-associated diseases. RECENT FINDINGS: KSHV, a gammaherpesvirus, causes several tumors and related diseases, including Kaposi sarcoma, a form of multicentric Castleman disease (KSHV-MCD), and primary effusion lymphoma. These most often develop in patients infected with human immunodeficiency virus (HIV). KSHV inflammatory cytokine syndrome (KICS) is a newly described syndrome with high mortality that has inflammatory symptoms-like MCD but not the pathologic lymph node findings...
January 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/27648817/monitoring-of-human-herpesviruses-6-and-7-dna-in-saliva-samples-during-the-acute-and-convalescent-phases-of-exanthem-subitum
#16
Yuki Miyazaki, Hikaru Namba, Sadayoshi Torigoe, Masahiro Watanabe, Nobuko Yamashita, Hirohito Ogawa, Tsuneo Morishima, Masao Yamada
The amounts of the DNAs of human herpesviruses-6 (HHV-6) and -7 (HHV-7) in saliva samples were monitored during the acute and convalescent phases of exanthem subitum (ES) to elucidate the kinetics of virus shedding after ES. A total of 247 saliva samples were collected from 17 children (5 males and 12 females: 8-31 months old at onset). The monitoring period ranged from 152 to 721 days after onset, and in 15 children it was longer than 1 year. Among the 17 cases, 16 were attributed to HHV-6B, while a single case was attributed to HHV-7...
September 20, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27625312/identification-of-viruses-in-cases-of-pediatric-acute-encephalitis-and-encephalopathy-using-next-generation-sequencing
#17
Jun-Ichi Kawada, Yusuke Okuno, Yuka Torii, Ryo Okada, Satoshi Hayano, Shotaro Ando, Yasuko Kamiya, Seiji Kojima, Yoshinori Ito
Acute encephalitis/encephalopathy is a severe neurological syndrome that is occasionally associated with viral infection. Comprehensive virus detection assays are desirable because viral pathogens have not been identified in many cases. We evaluated the utility of next-generation sequencing (NGS) for detecting viruses in clinical samples of encephalitis/encephalopathy patients. We first determined the sensitivity and quantitative performance of NGS by comparing the NGS-determined number of sequences of human herpesvirus-6 (HHV-6) in clinical serum samples with the HHV-6 load measured using real-time PCR...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27618318/castleman-disease-of-the-thorax-clinical-radiologic-and-pathologic-correlation-from-the-radiologic-pathology-archives
#18
Seth J Kligerman, Aaron Auerbach, Teri J Franks, Jeffrey R Galvin
Castleman disease is a complex lymphoproliferative disease pathologically divided into two subtypes, the hyaline vascular variant (HVV) and the plasma cell variant (PCV). The HVV is the most common, is thought to represent a benign neoplasm of lymph node stromal cells, and is treated with surgical resection. It is most commonly found in the mediastinum, where it classically appears as a unicentric, avidly enhancing mass at computed tomography (CT) and magnetic resonance imaging. This appearance can mimic other avidly enhancing mediastinal masses, and location, clinical history, laboratory data, and nuclear medicine single photon emission CT (SPECT) and positron emission tomography (PET) studies can help narrow the differential diagnosis...
September 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27563201/prevalence-of-herpesviruses-in-gingivitis-and-chronic-periodontitis-relationship-to-clinical-parameters-and-effect-of-treatment
#19
Rucha Shah, Dhoom Singh Mehta
BACKGROUND: Assess the prevalence of herpesviruses in healthy subjects, gingivitis, and chronic periodontitis patients, to assess the relationship between the prevalence of herpesviruses and periodontal clinical parameters, and to evaluate the effect of phase-I therapy on the level of viral detection. MATERIALS AND METHODS: Hundred patients consisting of 20 healthy subjects, 40 gingivitis, and 40 chronic periodontitis were included in the study. Clinical parameters recorded included plaque index, gingival index, sulcus bleeding index, probing depth, and clinical attachment level...
May 2016: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/27552439/virome-characterisation-from-guthrie-cards-in-children-who-later-developed-acute-lymphoblastic-leukaemia
#20
G Bogdanovic, C Pou, M Barrientos-Somarribas, A Bjerkner, E Honkaniemi, T Allander, B Andersson, B Gustafsson
BACKGROUND: Some childhood acute lymphoblastic leukaemias (ALL) can be traced back to a prenatal origin, where a virus infection could be involved in the first pre-leukaemic clone development. The DNA virome of 95 children who later developed ALL was characterised from neonatal blood spots (NBS) using unbiased next-generation sequencing (NGS) and compared with the virome of 95 non-ALL controls. METHODS: DNA was individually extracted from the ALL-patients and controls, pooled, randomly amplified and sequenced using the Illumina MiSeq Sequencing System...
October 11, 2016: British Journal of Cancer
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