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https://www.readbyqxmd.com/read/27273928/brief-report-management-of-chronic-post-chikungunya-rheumatic-disease-the-martinican-experience
#1
Marie Blettery, Lauren Brunier, Kathleen Polomat, Florence Moinet, Christophe Deligny, Serge Arfi, Georges Jean-Baptiste, Michel De Bandt
OBJECTIVE: To describe chronic chikungunya manifestations seen during the outbreak in the Caribbean from December 2013 to January 2015. METHODS: Patients were seen at our center, the only rheumatology department in Martinique Island, and were examined by a senior rheumatologist using a standard care report form. Chikungunya was diagnosed collectively based on consensus among all clinicians. The median time from onset of acute chikungunya to the first rheumatology consultation was calculated, severity was evaluated based on clinical scales and the degree of joint destruction, and each patient's treatment was recorded...
November 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/26697765/treating-to-target-in-established-rheumatoid-arthritis-challenges-and-opportunities-in-an-era-of-novel-targeted-therapies-and-biosimilars
#2
REVIEW
Thasia G Woodworth, Alfons A den Broeder
There is increasing consensus that periodic monitoring of disease activity status in rheumatoid arthritis (RA) patients to achieve and maintain remission, or at least low disease activity (LDA), the so-called treat to target (T2T) improves outcomes regardless of the duration of disease. Based on systematic literature reviews (SLRs) of clinical trials and registries, International Recommendations published in 2015 represent expert opinion describing efficacy and safety of conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) and biologic DMARDs (bDMARDs)...
August 2015: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/26184529/lymphopenia-in-early-arthritis-impact-on-diagnosis-and-3-year-outcomes-espoir-cohort
#3
Carole Duquenne, Divi Cornec, Thierry Marhadour, Sandrine Jousse-Joulin, Alain Cantagrel, Stephan Pavy, Valérie Devauchelle-Pensec, Alain Saraux
OBJECTIVES: In patients with early arthritis naive to disease-modifying antirheumatic drugs, we evaluated the prevalence of initial and persistent lymphopenia, underlying diagnoses, and risk of infection or malignancy. METHODS: Eight hundred and thirteen patients with early arthritis included in the ESPOIR cohort had a clinical examination, laboratory tests (viral serology, immunological tests, and cytokine profile), and radiographs. We determined the prevalence of lymphopenia at baseline and after 3 years, associated factors, diagnoses, and risk of infection or malignancy...
December 2015: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/25365086/vectra-da-for-the-objective-measurement-of-disease-activity-in-patients-with-rheumatoid-arthritis
#4
REVIEW
O G Segurado, E H Sasso
Quantitative and regular assessment of disease activity in rheumatoid arthritis (RA) is required to achieve treatment targets such as remission and to optimize clinical outcomes. To assess inflammation accurately, predict joint damage and monitor treatment response, a measure of disease activity in RA should reflect the pathological processes resulting in irreversible joint damage and functional disability. The Vectra DA blood test is an objective measure of disease activity for patients with RA. Vectra DA provides an accurate, reproducible score on a scale of 1 to 100 based on the concentrations of 12 biomarkers that reflect the pathophysiologic diversity of RA...
September 2014: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/23259623/update-on-treatment-of-psoriatic-arthritis
#5
REVIEW
Philip Mease
Some of this past year's key papers or abstracts on psoriatic arthritis (PsA) assessment and treatment are reviewed in this paper. Treatment begins with identification of the PsA patient. Several screening questionnaires have been developed to be used in dermatology and primary care settings to identify which patients with psoriasis have developed PsA as opposed to other common musculoskeletal problems, such as osteoarthritis and fibromyalgia, thus increasing case-finding and targeting referral. PsA can present in a heterogeneous manner, involving arthritis, enthesitis, dactylitis, spondylitis, and skin and nail disease...
2012: Bulletin of the NYU Hospital for Joint Diseases
https://www.readbyqxmd.com/read/23072741/treat-to-target-not-as-simple-as-it-appears
#6
Theodore Pincus, Isabel Castrejón, Martin J Bergman, Yusuf Yazici
Treat-to-target as a strategy for rheumatoid arthritis (RA) is now widely advocated based on strong evidence. Nonetheless, implementation of treat-to-target raises caveats, as is the case with all clinical care strategies. The target of remission or even low disease activity does not apply to all individual patients, some of whom are affected by concomitant fibromyalgia, other comorbidities, joint damage, and/or who simply prefer to maintain current status and avoid risks of more aggressive therapies. No single universal 'target' measure or index exists for all individual RA patients...
July 2012: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/22546240/review-of-dercum-s-disease-and-proposal-of-diagnostic-criteria-diagnostic-methods-classification-and-management
#7
REVIEW
Emma Hansson, Henry Svensson, Håkan Brorson
UNLABELLED: DEFINITION AND CLINICAL PICTURE: We propose the minimal definition of Dercum's disease to be generalised overweight or obesity in combination with painful adipose tissue. The associated symptoms in Dercum's disease include fatty deposits, easy bruisability, sleep disturbances, impaired memory, depression, difficulty concentrating, anxiety, rapid heartbeat, shortness of breath, diabetes, bloating, constipation, fatigue, weakness and joint aches. CLASSIFICATION: We suggest that Dercum's disease is classified into: I...
2012: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/19481000/hepatitis-c-associated-rheumatic-disorders
#8
REVIEW
Dan Buskila
Hepatitis C virus (HCV) is an important causative agent of liver diseases. However, HCV infection is also associated with numerous hematologic, renal, dermatologic, rheumatic, and autoimmune disorders. These include arthralgia, arthritis, vasculitis, sicca syndrome, myalgia, and fibromyalgia. The purpose of this article is to review the prevalence and spectrum of rheumatic disorders and autoimmune phenomena in HCV-infected patients. It evaluates and current treatment options including nonsteroidal anti-inflammatory drugs, low-dose corticosteroids, hydroxychloroquine, methotrexate, penicillamine, combined antiviral therapy, cyclosporin A, anti-TNF-a agents, and rituximab...
February 2009: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/18930991/occurrence-and-correlates-of-fatigue-in-psoriatic-arthritis
#9
J A Husted, B D Tom, C T Schentag, V T Farewell, D D Gladman
OBJECTIVE: To determine the relationship between fatigue and disease-related and psychosocial variables in psoriatic arthritis (PsA). METHOD: 499 patients attending the University of Toronto PsA Clinic were administered the modified fatigue severity scale (mFSS). At the time of mFSS administration, clinical and laboratory measures of disease activity and damage were recorded. Linear regression models were used to examine the cross-sectional relationship between disease-related and psychosocial variables and mFSS scores...
October 2009: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/17056293/rheumatologic-manifestations-of-chronic-hepatitis-c-infection
#10
REVIEW
Christian Lormeau, Géraldine Falgarone, Dominique Roulot, Marie-Christophe Boissier
The many rheumatologic manifestations associated with chronic hepatitis C virus (HCV) infection include arthralgia, myalgia, arthritis, vasculitis, and sicca syndrome. Arthralgia is the most common extrahepatic manifestation and may indicate mixed cryoglobulinemia or an adverse reaction to interferon therapy. HCV arthritis unrelated to cryoglobulinemia is far less common but constitutes an independent entity. The picture may mimic rheumatoid arthritis (RA), particularly as rheumatoid factor is present in 50-80% of cases...
December 2006: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/16151786/-polymyalgia-rheumatica-myalgic-syndrome-or-occult-vasculitis
#11
REVIEW
B Hellmich, W L Gross
Polymyalgia rheumatica (PMR) is a chronic inflammatory disorder of unknown etiology which typically presents with symmetric myalgias in the shoulder and pelvic girdles. Other clinical signs include the rapid onset of symptoms and the almost exclusive manifestation in the elderly population. In around 20% of cases, PMR is associated with giant cell arteritis (GCA). However, new imaging techniques suggest that the prevalence of subclinical GCA (e. g. aortitis) in PMR is probably higher. Acute phase reactants like erythrocyte sedimentation rate and c-reactive protein are usually elevated...
November 2005: Der Internist
https://www.readbyqxmd.com/read/15067429/eosinophilia-in-rheumatologic-diseases-a-prospective-study-of-1000-cases
#12
REVIEW
Ayşe Kargili, Nüket Bavbek, Arif Kaya, Ali Koşar, Yaşar Karaaslan
The role of eosinophilia in connective tissue diseases and the relationship between symptoms of rheumatic disease and eosinophilia have not been clearly established. The purpose of the present study was to explore the prevalence of eosinophilia in rheumatologic disease and determine its relationship to the symptoms. One thousand patients who applied to our rheumatology outpatient clinic between 2001 and 2002 were prospectively studied. The upper limit of normal blood eosinophil numbers was determined as 500 cells/microl of blood...
November 2004: Rheumatology International
https://www.readbyqxmd.com/read/11982303/lyme-arthritis
#13
REVIEW
Elena M Massarotti
Infection with B. burgdorferi can cause a large joint inflammatory arthritis in patients who have not been treated for early Lyme disease; the knee is the most common joint affected. The diagnosis depends on a history of known exposure to the spirochete, characteristic clinical features, and serologic studies (ELISA and Western blot) confirming exposure to the spirochete. In most patients, antibiotic therapy is curative, but in a smaller percentage of patients, the presence of the HLA-DR beta 1*0401 haplotype can trigger treatment-resistant arthritis, in which antibiotic therapy is ineffective; in these instances, remittive agents, such as hydroxychloroquine and methotrexate, are indicated...
March 2002: Medical Clinics of North America
https://www.readbyqxmd.com/read/8591645/the-epidemiology-of-drug-treatment-failure-in-rheumatoid-arthritis
#14
REVIEW
F Wolfe
The length of time that patients remain on anti-rheumatic therapy is an important measure of the effectiveness of that therapy since length of time on therapy is a composite measure that accounts for sustained, positive therapeutic benefit as well as negative therapeutic benefit (e.g. adverse reactions, unacceptable costs and loss of efficacy), and accounts for noise (non-compliance, psychological factors, misunderstanding, etc.). Effectiveness is a measure of how well a drug does work, while efficacy, the measure used in randomized controlled trials, means that a drug can work; however, efficacy may or may not translate to usefulness in the clinic...
November 1995: Baillière's Clinical Rheumatology
https://www.readbyqxmd.com/read/2476133/immune-responses-to-borrelia-burgdorferi-in-patients-with-reactive-arthritis
#15
COMPARATIVE STUDY
C M Weyand, J J Goronzy
In reactive arthritis (ReA), including Reiter's syndrome, a close relationship between chronic enteric and genitourinary infections and the clinical features of enthesitis has been described. In contrast, in Lyme arthritis, a distinct clinical entity, chronic infection with the tick-transmitted spirochete Borrelia burgdorferi has been associated with the disease. In a prospective study, 51 patients with ReA were tested for evidence of chlamydial and spirochetal infection. The presence of Chlamydia was determined by culture in 8 patients, and 7 additional patients had markedly elevated antibody titers...
September 1989: Arthritis and Rheumatism
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