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https://www.readbyqxmd.com/read/28721526/genetic-characterization-of-human-hydatid-cysts-shows-coinfection-by-echinococcus-canadensis-g7-and-echinococcus-granulosus-sensu-stricto-g1-in-argentina
#1
María Florencia Debiaggi, Silvia Viviana Soriano, Nora Beatriz Pierangeli, Lorena Evelina Lazzarini, Luis Alfredo Pianciola, Melina Leonor Mazzeo, Sergio Moguillansky, Juan Angel Basualdo Farjat
Human cystic echinococcosis caused by the larval stage of Echinococcus granulosus sensu lato (s.l.) is a highly endemic disease in the province of Neuquén, Patagonia, Argentina. Human infections with E. granulosus sensu stricto (s.s.) G1 and Echinococcus canadensis G6 were reported in Neuquén in previous studies, whereas four genotypes were identified in livestock: G1, G3, G6, and G7. The aim of this study was to identify the genotypes of E. granulosus s.l. isolates from humans of Neuquén province, Patagonia, Argentina, through the 2005-2014 period...
July 18, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28719956/a-case-of-ectopic-peritoneal-paragonimiasis-mimicking-diverticulitis-or-abdominal-abscess
#2
Min Jae Kim, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Yong Sik Yoon, Kyung Won Kim, Jaeeun Cho, Jong-Yil Chai, Yong Pil Chong
Paragonimiasis is a parasitic disease caused by Paragnonimus species. The primary site of infection is the lung, and extrapulmonary involvement is also reported. When infected with Paragonimus westermani, which is the dominant species in Korea, the central nervous system is frequently involved along with the liver, intestine, peritoneal cavity, retroperitoneum, and abdominal wall. Ectopic paragonimiasis raises diagnostic challenge since it is uncommon and may be confused with malignancy or other inflammatory diseases...
June 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28719882/antileishmanial-activity-and-tubulin-polymerization-inhibition-of-podophyllotoxin-derivatives-on-leishmania-infantum
#3
José Miguel Escudero-Martínez, Yolanda Pérez-Pertejo, Rosa M Reguera, María Ángeles Castro, María Victoria Rojo, Carolina Santiago, Andrés Abad, Pablo Anselmo García, José Luis López-Pérez, Arturo San Feliciano, Rafael Balaña-Fouce
Leishmania microtubules play an important role not only in cell division, but also in keeping the shape of the parasite and motility of its free-living stages. Microtubules result from the self-assembly of alpha and beta tubulins, two phylogenetically conserved and very abundant eukaryotic proteins in kinetoplastids. The colchicine binding domain has inspired the discovery and development of several drugs currently in clinical use against parasites. However, this domain is less conserved in kinetoplastids and may be selectively targeted by new compounds...
June 28, 2017: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/28715291/isolation-of-brucella-pinnipedialis-from-grey-seals-halichoerus-grypus-in-the-baltic-sea
#4
Varpu Hirvelä-Koski, Minna Nylund, Teresa Skrzypczak, Petra Heikkinen, Kaarina Kauhala, Maryne Jay, Marja Isomursu
Brucella infection in seals was reported for the first time in 1994 around the coast of Scotland. Since then, marine mammal Brucella infections were found to be widely distributed in the northern hemisphere. Two Brucella species affect marine mammals: Brucella pinnipedialis in pinnipeds and Brucella ceti in cetaceans. We examined the livers of Baltic grey seals (Halichoerus grypus) from the Finnish coast (n=122) hunted, found dead, or killed as by-catch in fishing gear in 2013-15 as part of population health monitoring...
July 17, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28708894/magnetic-resonance-imaging-and-spectroscopy-for-differential-assessment-of-liver-abnormalities-induced-by-opisthorchis-felineus-in-an-animal-model
#5
Alexandra G Pershina, Vladimir V Ivanov, Lina V Efimova, Oleg B Shevelev, Sergey V Vtorushin, Tatjana V Perevozchikova, Alexey E Sazonov, Ludmila M Ogorodova
BACKGROUND: European liver fluke Opisthorchis felineus, causing opisthorchiasis disease, is widespread in Russia, Ukraine, Kazakhstan and sporadically detected in the EU countries. O. felineus infection leads to hepatobiliary pathological changes, cholangitis, fibrosis and, in severe cases, malignant transformation of bile ducts. Due to absence of specific symptoms, the infection is frequently neglected for a long period. The association of opisthorchiasis with almost incurable bile duct cancer and rising international migration of people that increases the risk of the parasitic etiology of liver fibrosis in non-endemic regions determine high demand for development of approaches to opisthorchiasis detection...
July 14, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28707393/malaria-epstein-barr-virus-infection-and-the-pathogenesis-of-burkitt-s-lymphoma
#6
Anthony R Mawson, Suvankar Majumdar
A geographical and causal connection has long been recognized between malaria, Epstein-Barr virus (EBV) infection and Burkitt's lymphoma (BL), but the underlying mechanisms remain obscure. Potential clues are that the malaria parasite Plasmodium falciparum selectively absorbs vitamin A from the host and depends on it for its biological activities; secondly, alterations in vitamin A (retinoid) metabolism have been implicated in many forms of cancer, including BL. The first author has proposed that the merozoite-stage malaria parasite, emerging from the liver, uses its absorbed vitamin A as a cell membrane destabilizer to invade the red blood cells, causing anemia and other signs and symptoms of the disease as manifestations of an endogenous form of hypervitaminosis A (Mawson AR...
July 13, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28705245/abscisic-acid-induces-a-transient-shift-in-signaling-that-enhances-nf-%C3%AE%C2%BAb-mediated-parasite-killing-in-the-midgut-of-anopheles-stephensi-without-reducing-lifespan-or-fecundity
#7
Elizabeth K K Glennon, Brandi K Torrevillas, Shannon F Morrissey, Jadrian M Ejercito, Shirley Luckhart
BACKGROUND: Abscisic acid (ABA) is naturally present in mammalian blood and circulating levels can be increased by oral supplementation. We showed previously that oral ABA supplementation in a mouse model of Plasmodium yoelii 17XNL infection reduced parasitemia and gametocytemia, spleen and liver pathology, and parasite transmission to the mosquito Anopheles stephensi fed on these mice. Treatment of cultured Plasmodium falciparum with ABA at levels detected in our model had no effects on asexual growth or gametocyte formation in vitro...
July 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28700426/coexisting-primary-ovarian-and-omental-hydatid-disease-mimicking-an-ovarian-neoplasm-a-case-report
#8
Emre E Tas, Gulin F Yegin Akcay, Fatma Yildirim, Filiz Yavuz
Hydatid disease is a parasitic infection that most commonly affects the liver and lungs, although the disease can arise in any part of the body. Cysts may mimic many benign and malignant conditions. The diagnosis cannot be confirmed preoperatively in all cases. A 44-yr-old menopausal woman was admitted to the department of gynecology with complaints of abdominal distention. A fixed abdominopelvic mass was identified. Radiology revealed a 20-cm mass with branched septations and solid components. CA-125 level was 55 kU/L, and Risk of Malignancy Index-2 score was 880...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28697986/temporalis-cysticerci-a-diagnostic-dilemma-and-review-of-literature
#9
Sunita Malik, Gurdarshan Singh, Gagandeep Kaur
Cysticercosis is a systemic parasitic infestation caused by ingesting the eggs of the pork tapeworm, Taenia solium. The central nervous system (CNS) is the most important primary site of infection and disease can present with solitary or multiple space occupying lesion. Other organs like subcutaneous tissues, muscles, heart, liver, lungs, and peritoneum are more frequently affected but maxillofacial region involvement is rare. The diagnosis of cysticercose is evoked on US examination and CT scan, but confirmation is only possible by FNAC (Fine Needle Aspiration Cytology) or histological examination in case of surgical removal of the oral lesion which can identify the Taenia solium larva...
July 8, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28690729/-unusual-location-of-multiple-hydatidosis-pancreatic-and-pelvic-about-a-case
#10
Lamyae Amro, Saloua El Fadili, Hind Serhane, Hafsa Sajiai, Salma Ait Batahar
Hydatid cyst is an infectious disease which is quite frequent in Morocco. Pelvic and pancreatic locations of this parasitic infection are rare, namely exceptional. We report the case of a 66-year old patient who was operated for liver hydatic cyst 6 years before, presenting for chest pain associated with hydatidoptysis. Chest X-ray objectified left hydropneumothorax. Thoraco-abdominopelvic CT showed mediastinal liquid mass as well as multiple hepatic, pancreatic (isthmus), pelvic and left under diaphragmatic cystic lesions...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28683329/abdominal-wall-hydatid-cyst-a-review-a-literature-with-a-case-report
#11
Abdulwahid M Salih, F H Kakamad, Zuhair D Hammood, Bzhwen Yasin, Dilshad M Ahmed
INTRODUCTION: Hydatid cyst (HC) disease is a serious health problem in endemic areas. It is a parasitic infection that commonly involves liver and lungs while muscular HC is rare. HC of abdominal wall was reported only six times. We reported a 39-year-old male presented with HC of the right loin who was managed surgically with brief literature review. CONCLUSION: HC should be put in the differential diagnosis of the abdominal wall masses. Its pre-operative diagnosis is important to prevent rupture with subsequent anaphylaxis and recurrence...
June 23, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28681301/investigations-on-the-effects-of-etoxazole-in-the-liver-and-kidney-of-wistar-rats
#12
Mehmet Yilmaz, Eyyup Rencuzogullari, Mustafa Canli
Pesticides are used to protect crops and to eliminate pests, though non-target organisms such as mammals are also affected from their usage. Etoxazole (organoflourine pesticide) is an acaricide used to combat spider mites which are the parasites of various crops. The present study aims to investigate the effects of etoxazole on the level of MDA (malondialdehyde) and activities of CAT (catalase), GPx (glutathione peroxidase), and AChE (acetylcholinesterase) in liver and kidney tissues of Wistar rats (Rattus norvegicus var...
July 6, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28680583/enhanced-inflammatory-cell-profiles-in-schistosomiasis-induced-pulmonary-vascular-remodeling
#13
Zahara Ali, Djuro Kosanovic, Ewa Kolosionek, Ralph T Schermuly, Brian B Graham, Alistair Mathie, Ghazwan Butrous
Schistosomiasis (bilharzia) is a neglected parasitic disease caused by trematode flatworms of the genus Schistosoma which affects over 240 million people worldwide. It is characterized by the formation of inflammatory granulomas around deposited parasite eggs. Recent studies have revealed that immune and inflammatory responses play a crucial role in pathogenesis of schistosomiasis. The aim of this paper is to systematically evaluate the number and distribution of inflammatory cells in S. mansoni-infected mice at different doses and time points...
March 2017: Pulmonary Circulation
https://www.readbyqxmd.com/read/28677516/seroepidemiology-of-toxoplasma-gondii-infection-in-patients-with-liver-disease-in-eastern-china
#14
A L Tian, G X Li, H M Elsheikha, D S Gardner, X Y Zhang, W Dong, X P Yang, Y Y Luo, H L Li, W Cong, X Q Zhu
The role of the protozoan parasite Toxoplasma gondii in the pathogenesis of liver disease has recently gained much interest. The aim of this study was to determine the prevalence and risk factors associated with T. gondii infection in patients with liver disease from three cities in Shandong and Henan provinces, China. A case-control study was conducted from December 2014 to November 2015 and included 1142 patients with liver disease and 1142 healthy controls. Serum samples were collected from all individuals and were examined with enzyme-linked immunosorbent assay for the presence of anti-T...
July 5, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28674451/novel-interventional-management-of-hepatic-hydatid-cyst-with-nanosecond-pulses-on-experimental-mouse-model
#15
Xinhua Chen, Ruiqing Zhang, Tuerganaili Aji, Yingmei Shao, Yonggang Chen, Hao Wen
The nanosecond pulsed electric field (nsPEF) is investigated as an alternative plan for benign hepatic hydatid cyst. Altogether 72 C57B6 mice were included. Normal group (n = 12) had no parasite injection and the other 60 mice were used to induce hydatid cyst in liver by injecting protoscolices in portal vein. The liver hydatid cysts were exposed to nsPEF with different doses and then follow up. The standard surgery was performed as positive control. The hydatid cyst growth was monitored by ultrasound; the morphology was checked by gross anatomy and pathology was tested by H&E stain...
July 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28666480/trend-and-causes-of-adult-mortality-in-kersa-health-and-demographic-surveillance-system-kersa-hdss-eastern-ethiopia-verbal-autopsy-method
#16
Wondimye Ashenafi, Frehywot Eshetu, Nega Assefa, Lemessa Oljira, Melkamu Dedefo, Desalew Zelalem, Negga Baraki, Melake Demena
BACKGROUND: The health problems of adults have been neglected in many developing countries, yet many studies in these countries show high rates of premature mortality in adults. Measuring adult mortality and its cause through verbal autopsy (VA) methods is becoming an important process for mortality estimates and is a good indicator of the overall mortality rates in resource-limited settings. The objective of this analysis is to describe the levels, distribution, and trends of adult mortality over time (2008-2013) and causes of adult deaths using VA in Kersa Health and Demographic Surveillance System (Kersa HDSS)...
July 1, 2017: Population Health Metrics
https://www.readbyqxmd.com/read/28662952/vaccination-against-histomonosis-limits-pronounced-changes-of-b-cells-and-t-cell-subsets-in-turkeys-and-chickens
#17
Taniya Mitra, Wilhelm Gerner, Fana Alem Kidane, Patricia Wernsdorf, Michael Hess, Armin Saalmüller, Dieter Liebhart
The protozoan parasite Histomonas meleagridis is the causative agent of histomonosis in gallinaceous birds. In turkeys, the disease can result in high mortality due to severe inflammation and necrosis in caecum and liver, whereas in chickens the disease is less severe. Recently, experimental vaccination was shown to protect chickens and turkeys against histomonosis but dynamics in the cellular immune response are not yet demonstrated. In the present work, different groups of birds of both species were vaccinated with attenuated, and/or infected with virulent histomonads...
June 26, 2017: Vaccine
https://www.readbyqxmd.com/read/28661024/a-follow-up-study-of-selected-biomarkers-of-health-in-cod-gadus-morhua-l-collected-from-the-southern-baltic-off-the-polish-coast
#18
J D Borucinska, D Morka, Z Grabowski, H Smith
Selected biomarkers of health were examined in 50 post-spawning cod Gadus morhua collected in November 2015 from the southern Baltic. The biomarkers included condition factor (CF), macroscopic lesions, histopathology of spleen, liver and gonads, and morphometry of follicular atresia and hepatic and splenic melanomacrophage cells (MMC). All fish appeared in good body condition. One fish had a dermal ulcer, and in seven, macroscopic nematodes were noted within body cavity. Microscopic lesions in the liver included biliary myxozoanosis, microsporidial and necrocentric granulomas, parasitic hepatitis, multifocal necrosis, foci of cellular alterations, spongiosis, peliosis and cytoplasmic fibrillar inclusions...
June 29, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28656619/an-unusual-cause-of-chest-pain-an-isolated-huge-cardiac-hydatid-cyst
#19
Begum Uygur, Fethi Emre Ustabasioglu, Huseyin Karakurt, Okan Akinci, Omer Celik
Hydatid disease is a human parasitic infection caused by the larval stage of Echinococcus granulosus. The most common locations for hydatid cysts are the liver and lungs. Cardiac involvement is rare, and isolated cardiac hydatid cysts are even more unusual. We report the case a 48-year-old female patient with an isolated huge cardiac hydatid cyst involving both the left ventricular free wall and the pericardium, and presenting with atypical chest pain. © 2017 Wiley Periodicals, Inc. J Clin Ultrasound, 2017...
June 27, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/28655574/cisplatin-along-with-herbal-drug-treatment-reduces-the-percentage-of-regulatory-t-cells-and-decreased-the-severity-of-experimental-visceral-leishmaniasis
#20
Heena Sachdeva, Sukhbir Kaur
BACKGROUND: Visceral leishmaniasis is the most alarming and devastating amongst the various forms of leishmaniases. It is caused by Leishmania donovani, an obligate intracellular parasite of macrophages that survives through immunosuppression. Absence of T regulatory cells provides complete clearance of the parasite. A few immunoprophylactics have been sought to battle instinctive leishmaniasis, with fluctuating achievement. Our previous studies have shown that treatment of L. donovani infected mice with cisplatin along with herbal drugs resulted in decreased parasite load with heightened delayed type hypersensitivity responses (DTH), increased levels of IgG2a, IFN-γ, IL-2, CD4+ cells, NK 1...
June 8, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
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