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https://www.readbyqxmd.com/read/29775485/plasmodium-parasite-exploits-host-aquaporin-3-during-liver-stage-malaria-infection
#1
Dora Posfai, Kayla Sylvester, Anupama Reddy, Jack G Ganley, Johannes Wirth, Quinlan E Cullen, Tushar Dave, Nobutaka Kato, Sandeep S Dave, Emily R Derbyshire
Within the liver a single Plasmodium parasite transforms into thousands of blood-infective forms to cause malaria. Here, we use RNA-sequencing to identify host genes that are upregulated upon Plasmodium berghei infection of hepatocytes with the hypothesis that host pathways are hijacked to benefit parasite development. We found that expression of aquaporin-3 (AQP3), a water and glycerol channel, is significantly induced in Plasmodium-infected hepatocytes compared to uninfected cells. This aquaglyceroporin localizes to the parasitophorous vacuole membrane, the compartmental interface between the host and pathogen, with a temporal pattern that correlates with the parasite's expansion in the liver...
May 18, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29774298/cystic-echinococcosis-in-marketed-offal-of-sheep-in-basrah-iraq-abattoir-based-survey-and-a-probabilistic-model-estimation-of-the-direct-economic-losses-due-to-hydatid-cyst
#2
Mohanad F Abdulhameed, Ihab Habib, Suzan A Al-Azizz, Ian Robertson
Cystic echinococcosis (CE) is a highly endemic parasitic zoonosis in Iraq with substantial impacts on livestock productivity and human health. The objectives of this study were to study the abattoir-based occurrence of CE in marketed offal of sheep in Basrah province, Iraq, and to estimate, using a probabilistic modelling approach, the direct economic losses due to hydatid cysts. Based on detailed visual meat inspection, results from an active abattoir survey in this study revealed detection of hydatid cysts in 7...
February 2018: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29774297/parasitic-and-zoonotic-meningoencephalitis-in-humans-and-equids-current-knowledge-and-the-role-of-halicephalobus-gingivalis
#3
REVIEW
ThankGod E Onyiche, Theresa O Okute, Oluwasina S Oseni, Dennis O Okoro, Abdullahi A Biu, Albert W Mbaya
Halicephalobus gingivalis is a saprophytic nematode parasite that causes a rare form of fatal meningoencephalomyelitis in equids, humans, and ruminants. This nematode has neurotropic activity, but has also been found in the kidney, liver, lungs, optic nerves and even heart of its host. Despite the zoonotic potential and severity of the disease, the epidemiology, pathogenesis, life cycle, and risk factors are poorly understood. Cases have been reported from several countries in Europe countries and North America but none is recorded in Africa except Egypt...
February 2018: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29774028/nlrp3-inflammasome-and-caspase-1-11-pathway-orchestrate-different-outcomes-in-the-host-protection-against-trypanosoma-cruzi-acute-infection
#4
Augusto F Paroli, Patricia V Gonzalez, Cintia Díaz-Luján, Luisina I Onofrio, Alfredo Arocena, Roxana C Cano, Eugenio A Carrera-Silva, Susana Gea
Infection with protozoan parasite Trypanosoma cruzi results in activation of nucleotide-binding domain and leucine-rich repeat containing receptors (NLRs). NLR activation leads to inflammasome formation, the activation of caspase-1, and the subsequent cleavage of IL-1β and IL-18. Considering that inflammasome activation and IL-1β induction by macrophages are key players for an appropriate T cell response, we investigated the relevance of NLR pyrin domain-containing 3 (NLRP3) and caspase-1/11 to elucidate their roles in the induction of different T cell phenotypes and the relationship with parasite load and hepatic inflammation during T...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29773137/microsatellite-pattern-analysis-of-neospora-caninum-from-a-naturally-infected-goat-fetus
#5
Lucía María Campero, María Laura Gos, Dadin Prando Moore, Javier Regidor-Cerrillo, Juan Manuel Unzaga, Gastón Moré, Luis Miguel Ortega-Mora, María Cecilia Venturini
Neospora caninum is an apicomplexan protozoan responsible for abortion in ruminants. The present study aimed to diagnose an abortion from an Anglo Nubian goat from a dairy herd located in Buenos Aires province, Argentina. The goat delivered a fetus of approximately 3 months gestation that was studied by indirect fluorescent antibody test (IFAT), Immunoblot (IB), histopathology (HP), immunohistochemistry (IHC), and molecular assays (PCR, sequencing and microsatellite genotyping). Interferon gamma knock-out mice were inoculated with a pool of tissues for isolation attempts...
May 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29772240/identification-and-characterization-of-the-zinc-finger-protein-sjzf-in-schistosoma-japonicum
#6
Ruixiang Zhang, Jian Li, Manyu Xiang, Qinghua Hong, Bin Xu, Wei Hu
Schistosomiasis represents one of the most prevalent parasitic infections affecting over 249 million people worldwide. The pathological damage is mainly caused by the eggs laid by female schistosomes. Zinc finger proteins (ZFPs) usually play critical roles in many biological functions. In this study, we cloned, identified and characterized the zinc finger protein SjZF of Schistosoma japonicum. SjZF ortholog proteins were also identified in S. mansoni, S. haematobium, Opisthorchis viverrini and O. sinensis. Fluorescence localization showed that SjZF was particularly expressed in the worm gut of both genders and the vitelline glands of females...
May 14, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29771992/first-description-of-echinococcus-ortleppi-and-cystic-echinococcosis-infection-status-in-chile
#7
Felipe Corrêa, Caroll Stoore, Pamina Horlacher, Mauricio Jiménez, Christian Hidalgo, Cristian A Alvarez Rojas, Guilherme Figueiredo Barros, Henrique Bunselmeyer Ferreira, Marcela Hernández, Gonzalo Cabrera, Rodolfo Paredes
Cystic echinococcosis (CE), a parasitic disease caused by the cestode Echinococcus granulosus sensu lato (s.l.), is a worldwide zoonotic infection. Although endemic in Chile, information on the molecular characteristics of CE in livestock remains scarce. Therefore we aimed to describe the status of infection with E. granulosus s.l. in cattle from central Chile and also to contribute to the study of the molecular epidemiology of this parasite. According to our results, the prevalence of CE is 18.84% in cattle, similar to previous reports from Chile, suggesting that the prevalence in Santiago Metropolitan area has not changed in the last 30 years...
2018: PloS One
https://www.readbyqxmd.com/read/29769113/thinking-beyond-opisthorchis-viverrini-for-risk-of-cholangiocarcinoma-in-the-lower-mekong-region-a-systematic-review-and-meta-analysis
#8
REVIEW
Jennifer A Steele, Carsten H Richter, Pierre Echaubard, Parichat Saenna, Virginia Stout, Paiboon Sithithaworn, Bruce A Wilcox
BACKGROUND: Cholangiocarcinoma (CCA) is a fatal bile duct cancer associated with infection by the liver fluke, Opisthorchis viverrini, in the lower Mekong region. Numerous public health interventions have focused on reducing exposure to O. viverrini, but incidence of CCA in the region remains high. While this may indicate the inefficacy of public health interventions due to complex social and cultural factors, it may further indicate other risk factors or interactions with the parasite are important in pathogenesis of CCA...
May 17, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29768571/pterobothrium-crassicolle-parasitizing-paralichthys-orbignyanus-osteichthyes-paralichthyidae-in-brazil
#9
Nilza N Felizardo, Marcelo Knoff, Jessica B Diniz, Eduardo J L Torres, Flávia A A Calixto, Sérgio C São Clemente
From September 2014 to November 2015, 30 Paralichthys orbignyanus specimens were obtained from Sepetiba Bay in the municipality of Rio de Janeiro, State of Rio de Janeiro, Brazil. The fishes were necropsied and cestode larvae were recovered from the abdominal cavity, mesentery, and serosas of the stomach, intestine, spleen, liver, kidney and gonads. Nineteen fish were parasitized by a total of 90 trypanorhynch plerocerci. Based on morphological characters, these were identified as Pterobothrium crassicolle...
May 14, 2018: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29764519/plasmodium-yoelii-infection-inhibits-murine-leukaemia-wehi-3-cell-proliferation-in-vivo-by-promoting-immune-responses
#10
Zhen-Zhen Tong, Zheng-Ming Fang, Qi Zhang, Yun Zhan, Yue Zhang, Wan-Fang Jiang, Xiao Hou, Yong-Long Li, Ting Wang
BACKGROUND: Leukaemia is a malignant leukocyte disorder with a high fatality rate, and current treatments for this disease are unsatisfactory. Therefore, new therapeutic strategies for leukaemia must be developed. Malaria parasite infection has been shown to be effective at combating certain neoplasms in animal experiments. This study is to demonstrate the anti-leukaemia activity of malaria parasite Plasmodium yoelii (P. yoelii) infection,. METHODS: In this study, the proportion of CD3, CD19, CD11b and Mac-3 cells was analysed by flow cytometry; the levels of IFN-γ and TNF-α in individual serum samples were measured by enzyme-linked immunosorbent assay, and the phagocytic activity of macrophages and natural killer (NK) cell activity were measured by flow cytometry...
May 16, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29762040/orally-bioavailable-and-effective-buparvaquone-lipid-based-nanomedicines-for-visceral-leishmaniasis
#11
Lindsay A Smith, Dolores Remedios Serrano, Marion Mauger, Francisco Bolás-Fernández, Maria Auxiliadora Dea-Ayuela, Aikaterini Lalatsa
Nano-enabled lipid based drug delivery systems offer a platform to overcome challenges encountered with current failed leads in the treatment of parasitic and infectious diseases. When prepared with FDA or EMA approved excipients, they can be readily translated without the need for further toxicological studies, while they remain affordable and amenable to scale-up. Buparvaquone (BPQ), a hydroxynapthoquinone with in vitro activity in the nanomolar range, failed to clinically translate as a viable treatment for visceral leishmaniasis due to its poor oral bioavailability limited by its poor aqueous solubility (BCS Class II drug)...
May 15, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29760143/developmental-sensitivity-in-schistosoma-mansoni-to-puromycin-to-establish-drug-selection-of-transgenic-schistosomes
#12
Hong-Bin Yan, Michael J Smout, Chuan Ju, Anne E Folley, Danielle E Skinner, Victoria H Mann, Alex Loukas, Wei Hu, Paul J Brindley, Gabriel Rinaldi
Schistosomiasis is considered the most important disease caused by helminth parasites, in terms of morbidity and mortality. Tools to facilitate gain- and loss- of-function approaches can be expected to precipitate the discovery of novel interventions, and drug selection of transgenic schistosomes would facilitate the establishment of stable lines of engineered parasites. Sensitivity of developmental stages of schistosomes to the aminonucleoside antibiotic puromycin was investigated. For the schistosomulum and sporocyst stages, viability was quantified by fluorescence microscopy following dual staining with fluorescein diacetate and propidium iodine...
May 14, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29758277/first-genetic-evidence-for-the-presence-of-the-rumen-fluke-paramphistomum-epiclitum-in-pakistan
#13
Qasim Ali, Imran Rashid, Muhammad Zubair Shabbir, Haroon Akbar, Kashif Shahzad, Kamran Ashraf, Neil Sargison, Umer Chaudhry
More than 70 species of the Superfamily Paramphistomoidea, have been identified in ruminants in different parts of the world. Most are pathogenic, causing amphistomosis. Adult flukes within this family have a predilection for the forestomach (rumen) or bile duct of the liver, where they may cause epithelial damage. Identification of adult Paramphistomum, Calicophoron, Gastrothylax and Fischoederius at the species level based on morphology requires specialised expertise, whereas molecular genetic marker analysis is more precise and transferable...
May 11, 2018: Parasitology International
https://www.readbyqxmd.com/read/29756728/-hydatid-disease-in-children-of-buenos-aires-province
#14
Pilar Álvarez, Nicolás Castiglione, Sergio Moreno, Jorge Bolpe
Hydatidosis is a parasitic zoonosis caused by Echinococcus granulosus. It is endemic in Argentina and in the province of Buenos Aires, especially to the south of the Rio Salado basin. During 2014 and 2016, the Department of Rural Zoonoses was notified of 479 cases of hydatidosis, with 12.1% confirmed in children under 18 years of age. Fifty-nine percent corresponded to males and the group of 13 to 17 years was the most prevalent one (47%). Sixty-four percent had liver involvement, 22% pulmonary involvement, 5% hepatopulmonary involvement, 5% splenic involvement and 4% cerebral involvement...
June 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29754074/structure-activity-relationship-of-new-antimalarial-1-aryl-3-susbtituted-propanol-derivatives-synthesis-preliminary-toxicity-profiling-parasite-life-cycle-stage-studies-target-exploration-and-targeted-delivery
#15
Miguel Quiliano, Adriana Pabón, Ernest Moles, Leonardo Bonilla-Ramirez, Isabelle Fabing, Kim Y Fong, Diego A Nieto-Aco, David W Wright, Juan C Pizarro, Ariane Vettorazzi, Adela López de Cerain, Eric Deharo, Xavier Fernández-Busquets, Giovanny Garavito, Ignacio Aldana, Silvia Galiano
Design, synthesis, structure-activity relationship, cytotoxicity studies, in silico drug-likeness, genotoxicity screening, and in vivo studies of new 1-aryl-3-substituted propanol derivatives led to the identification of nine compounds with promising in vitro (55, 56, 61, 64, 66, and 70-73) and in vivo (66 and 72) antimalarial profiles against Plasmodium falciparum and Plasmodium berghei. Compounds 55, 56, 61, 64, 66 and 70-73 exhibited potent antiplasmodial activity against chloroquine-resistant strain FCR-3 (IC50 s < 0...
April 24, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29753338/clonorchis-sinensis-and-clonorchiasis-the-relevance-of-exploring-genetic-variation
#16
Daxi Wang, Neil D Young, Pasi K Korhonen, Robin B Gasser
Parasitic trematodes (flukes) cause substantial mortality and morbidity in humans. The Chinese liver fluke, Clonorchis sinensis, is one of the most destructive parasitic worms in humans in China, Vietnam, Korea and the Russian Far East. Although C. sinensis infection can be controlled relatively well using anthelmintics, the worm is carcinogenic, inducing cholangiocarcinoma and causing major suffering in ~15 million people in Asia. This chapter provides an account of C. sinensis and clonorchiasis research-covering aspects of biology, epidemiology, pathogenesis and immunity, diagnosis, treatment and control, genetics and genomics...
2018: Advances in Parasitology
https://www.readbyqxmd.com/read/29743881/host-defense-versus-immunosuppression-unisexual-infection-with-male-or-female-schistosoma-mansoni-differentially-impacts-the-immune-response-against-invading-cercariae
#17
Martina Sombetzki, Nicole Koslowski, Anne Rabes, Sonja Seneberg, Franziska Winkelmann, Carlos Fritzsche, Micha Loebermann, Emil C Reisinger
Infection with the intravascular diecious trematode Schistosoma spp . remains a serious tropical disease and public health problem in the developing world, affecting over 258 million people worldwide. During chronic Schistosoma mansoni infection, complex immune responses to tissue-entrapped parasite eggs provoke granulomatous inflammation which leads to serious damage of the liver and intestine. The suppression of protective host immune mechanisms by helminths promotes parasite survival and benefits the host by reducing tissue damage...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29743474/a-comprehensive-model-for-assessment-of-liver-stage-therapies-targeting-plasmodium-vivax-and-plasmodium-falciparum
#18
Alison Roth, Steven P Maher, Amy J Conway, Ratawan Ubalee, Victor Chaumeau, Chiara Andolina, Stephen A Kaba, Amélie Vantaux, Malina A Bakowski, Richard Thomson Luque, Swamy Rakesh Adapa, Naresh Singh, Samantha J Barnes, Caitlin A Cooper, Mélanie Rouillier, Case W McNamara, Sebastian A Mikolajczak, Noah Sather, Benoît Witkowski, Brice Campo, Stefan H I Kappe, David E Lanar, François Nosten, Silas Davidson, Rays H Y Jiang, Dennis E Kyle, John H Adams
Malaria liver stages represent an ideal therapeutic target with a bottleneck in parasite load and reduced clinical symptoms; however, current in vitro pre-erythrocytic (PE) models for Plasmodium vivax and P. falciparum lack the efficiency necessary for rapid identification and effective evaluation of new vaccines and drugs, especially targeting late liver-stage development and hypnozoites. Herein we report the development of a 384-well plate culture system using commercially available materials, including cryopreserved primary human hepatocytes...
May 9, 2018: Nature Communications
https://www.readbyqxmd.com/read/29740446/antigenicity-of-leishmania-activated-c-kinase-antigen-lack-in-human-peripheral-blood-mononuclear-cells-and-protective-effect-of-prime-boost-vaccination-with-pci-neo-lack-plus-attenuated-lack-expressing-vaccinia-viruses-in-hamsters
#19
Laura Fernández, Eugenia Carrillo, Lucas Sánchez-Sampedro, Carmen Sánchez, Ana Victoria Ibarra-Meneses, M Angeles Jimenez, Valter Dos Anjos Almeida, Mariano Esteban, Javier Moreno
Leishmania -activated C-kinase antigen (LACK) is a highly conserved protein among Leishmania species and is considered a viable vaccine candidate for human leishmaniasis. In animal models, prime-boost vaccination with LACK-expressing plasmids plus attenuated vaccinia viruses (modified vaccinia Ankara [MVA] and mutant M65) expressing LACK, has been shown to protect against cutaneous leishmaniasis (CL). Further, LACK demonstrated to induce the production of protective cytokines in patients with active CL or cured visceral leishmaniasis, as well as in asymptomatic individuals from endemic areas...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29739900/bone-marrow-is-a-major-parasite-reservoir-in-plasmodium-vivax-infection
#20
Nicanor Obaldia, Elamaran Meibalan, Juliana M Sa, Siyuan Ma, Martha A Clark, Pedro Mejia, Roberto R Moraes Barros, William Otero, Marcelo U Ferreira, James R Mitchell, Danny A Milner, Curtis Huttenhower, Dyann F Wirth, Manoj T Duraisingh, Thomas E Wellems, Matthias Marti
Plasmodium vivax causes heavy burdens of disease across malarious regions worldwide. Mature P. vivax asexual and transmissive gametocyte stages occur in the blood circulation, and it is often assumed that accumulation/sequestration in tissues is not an important phase in their development. Here, we present a systematic study of P. vivax stage distributions in infected tissues of nonhuman primate (NHP) malaria models as well as in blood from human infections. In a comparative analysis of the transcriptomes of P...
May 8, 2018: MBio
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