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https://www.readbyqxmd.com/read/28802653/in-vitro-interactions-of-malachite-green-and-leucomalachite-green-with-hepatic-drug-metabolizing-enzyme-systems-in-the-rainbow-trout-onchorhyncus-mykiss
#1
Carlo Nebbia, Flavia Girolami, Monica Carletti, Laura Gasco, Ivo Zoccarato, Alessandra Giuliano Albo
Malachite green (MG) has been widely used in aquaculture to treat a number of microbial and parasitic diseases. It is currently banned in the EU because of the high cytotoxicity and carcinogenic activity, which is also shared by leucomalachite green (LMG), a reduced MG metabolite that can persist in fish tissues for months. There is scant information about the ability of either compound to interact with drug metabolizing enzymes in fish. Therefore we evaluated the in vitro effects of MG and LMG (25, 50 and 100μM) on some DMEs and glutathione (GSH) content in rainbow trout liver subfractions...
August 9, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28800774/angiostrongylus-vasorum-in-wolves-in-italy-prevalence-and-pathological-findings
#2
Claudio De Liberato, Goffredo Grifoni, Raniero Lorenzetti, Roberta Meoli, Cristiano Cocumelli, Antonio Mastromattei, Francesco Scholl, Pasquale Rombolà, Pietro Calderini, Gianpaolo Bruni, Claudia Eleni
BACKGROUND: Angiostrongylus vasorum is a nematode residing in the heart and pulmonary vessels of dogs and wild carnivores. In Europe the red fox is its reservoir, while only three records from wolves have been published. Angiostrongylus vasorum has a worldwide distribution, and many pieces of evidence demonstrate that it is spreading from endemic areas to new ones. In Italy, A. vasorum was reported with increasing frequency in dogs and foxes in the last decades, and now it is considered endemic throughout the country...
August 11, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28799088/metazoan-parasites-from-odontocetes-off-new-zealand-new-records
#3
Kristina Lehnert, Haseeb Randhawa, Robert Poulin
Information about the parasite fauna of spectacled porpoises and cetaceans from New Zealand waters in general is scarce. This study takes advantage of material archived in collections of the Otago Museum in Dunedin and Massey University in Auckland, sampled from cetacean species found stranded along the New Zealand coastline between 2007 and 2014. Parasites from seven species of cetaceans (spectacled porpoise, Phocoena dioptrica (n = 2 individuals examined); pygmy sperm whale (n = 1); long-finned pilot whale, Globicephala melas (n = 1); Risso's dolphin, Grampus griseus (n = 1); short-beaked common dolphin, Delphinus delphis (n = 7); striped dolphin, Stenella coeruleoalba (n = 3) and dusky dolphin, Lagenorhynchus obscurus (n = 2)) from the respiratory and gastro-intestinal tract, cranial sinus, liver, urogenital and mammary tract, fascia and blubber were investigated...
August 10, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28798938/evidence-for-tissue-toxicity-in-balb-c-exposed-to-a-long-term-treatment-with-oxiranes-compared-to-meglumine-antimoniate
#4
Luiz Filipe Gonçalves Oliveira, Franklin Souza-Silva, Léa Cysne-Finkelstein, Kíssila Rabelo, Juliana Fernandes Amorim, Adriana de Souza Azevedo, Saulo Cabral Bourguignon, Vitor Francisco Ferreira, Marciano Viana Paes, Carlos Roberto Alves
Leishmaniasis remains a serious public health problem in developing countries without effective control, whether by vaccination or chemotherapy. Part of the failure of leishmaniasis control is due to the lack of new less toxic and more effective drugs able to eliminate both the lesions and the parasite. Oxiranes derived from naphthoquinones now being assayed are promising drugs for the treatment of this group of diseases. The predicted pharmacokinetic properties and toxicological profiles of epoxy-α-lapachone and epoxymethoxy-lawsone have now been compared to those of meglumine antimoniate, and histological changes induced by these drugs in noninfected BALB/c mice tissues are described...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28798750/heme-oxygenase-1-expression-contributes-to-the-immunoregulation-induced-by-fasciola-hepatica-and-promotes-infection
#5
Paula Carasi, Ernesto Rodríguez, Valeria da Costa, Sofía Frigerio, Natalie Brossard, Verónica Noya, Carlos Robello, Ignacio Anegón, Teresa Freire
Fasciola hepatica, also known as the liver fluke, is a trematode that infects livestock and humans causing fasciolosis, a zoonotic disease of increasing importance due to its worldwide distribution and high economic losses. This parasite immunoregulates the host immune system by inducing a strong Th2 and regulatory T immune response by immunomodulating dendritic cell (DC) maturation and alternative activation of macrophages. In this paper, we show that F. hepatica infection in mice induces the upregulation of heme-oxygenase-1 (HO-1), the rate-limiting enzyme in the catabolism of free heme that regulates the host inflammatory response...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28798366/elevated-serum-antibody-against-schistosoma-japonicum-hsp60-as-a-promising-biomarker-for-liver-pathology-in-schistosomiasis
#6
Xiaojun Chen, Wei Li, Yalin Li, Lei Xu, Sha Zhou, Jifeng Zhu, Zhipeng Xu, Feng Liu, Dandan Lin, Fei Hu, Yuemin Liu, Wen Jiang, Liwang Cui, Chuan Su
The pathology associated with Schistosoma japonicum (S. japonicum) infection in humans is attributed to parasite egg-induced granulomatous inflammation and fibrosis in the host liver. Currently, a marker that is reliable, cheap, less device-dependent, and can be easily and repeatedly used on a large scale to monitor the progression of liver pathology in schistosomiasis japonica endemic areas is lacking. The levels of serum S. japonicum heat shock protein 60 (SjHSP60)-specific IgG and its subtype antibodies in animals (mice and rabbits) or patients with schistosomiasis were measured by ELISA...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28795594/the-battle-of-worldviews-a-case-study-of-liver-fluke-infection-in-khon-kaen-thailand
#7
Sara Samiphak, S Leonard Syme
Control efforts to reduce infection from the parasitic flatworm Opisthorchis viverrini have progressed through understanding the epidemiology of Opisthorchis viverrini, antiparasitic drug developments, technological innovations, health education promoting cooking of fish, and improved hygienic defecation. Yet the problem persists. The case study method was used to examine the fundamental cause of the liver fluke infection problem. Evidence shows that the liver fluke-infected population does not care about living a long life...
January 1, 2017: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/28795224/extrusion-of-contracaecum-osculatum-nematode-larvae-from-the-liver-of-cod-gadus-morhua
#8
S Zuo, L Barlaup, A Mohammadkarami, A Al-Jubury, D Chen, P W Kania, K Buchmann
Baltic cod livers have during recent years been found increasingly and heavily infected with third-stage larvae of Contracaecum osculatum. The infections are associated with an increasing population of grey seals which are final hosts for the parasite. Heavy worm burdens challenge utilization and safety of the fish liver products, and technological solutions for removal of worms are highly needed. We investigated the attachment of the worm larvae in liver tissue by use of histochemical techniques and found that the cod host encapsulates the worm larvae in layers of host cells (macrophages, fibroblasts) supported by enclosures of collagen and calcium...
August 9, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28793022/kidney-involvement-in-malaria-an-update
#9
Geraldo Bezerra da Silva, José Reginaldo Pinto, Elvino José Guardão Barros, Geysa Maria Nogueira Farias, Elizabeth De Francesco Daher
Malaria is an infectious disease of great importance for Public Health, as it is the most prevalent endemic disease in the world, affecting millions of people living in tropical areas of the globe. Kidney involvement is relatively frequent in infections by P. falciparum and P. malariae, but has also been described in the infection by P. vivax. Kidney complications in malaria mainly occur due to hemodynamic dysfunction and immune response. Liver complications leading to hepatomegaly, jaundice and hepatic dysfunction can also contribute to the occurrence of acute kidney injury...
2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28783896/liver-fluke-associated-biliary-tract-cancer
#10
REVIEW
Piyapan Prueksapanich, Panida Piyachaturawat, Prapimphan Aumpansub, Wiriyaporn Ridtitid, Roongruedee Chaiteerakij, Rungsun Rerknimitr
Cholangiocarcinoma (CCA) is an aggressive cancer arising from epithelial cells of the bile duct. Most patients with CCA have an unresectable tumor at the time of diagnosis. In Western countries, the risk of CCA increases in patients with primary sclerosing cholangitis, whereas liver fluke infection appears to be the major risk factor for CCA in Asian countries. A diagnosis of liver fluke infection often relies on stool samples, including microscopic examination, polymerase chain reaction-based assays, and fluke antigen detection...
August 9, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28775313/disposition-and-residue-depletion-of-metronidazole-in-pigs-and-broilers
#11
Yuanhu Pan, Jiliang Yi, Bo Zhou, Shuyu Xie, Dongmei Chen, Yanfei Tao, Wei Qu, Zhenli Liu, Lingli Huang, Zonghui Yuan
Metronidazole (MNZ) is used in veterinary medicine for the treatment of anaerobic infections and a variety of protozoal and parasitic diseases. Current study has been conducted to examine the disposition and residue depletion studies of MNZ and its main metabolites in pigs and broilers. After a single oral administration of MNZ, the concentrations of MNZ and its main metabolites in the excreta of pigs and broilers were determined by LC-MS/MS. More than 75% of the drug was recovered within 14 days, of which MNZ accounted for about 40%, MNZ-OH 20-25% and MAA less than 10%...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28771523/differential-expression-of-pathogenic-genes-of-entamoeba-histolytica-vs-e-dispar-in-a-model-of-infection-using-human-liver-tissue-explants
#12
Cecilia Ximénez, Enrique González, Miriam Nieves, Ulises Magaña, Patricia Morán, Marco Gudiño-Zayas, Oswaldo Partida, Eric Hernández, Liliana Rojas-Velázquez, Ma Carmen García de León, Héctor Maldonado
We sought to establish an ex vivo model for examining the interaction of E. histolytica with human tissue, using precision-cut liver slices (PCLS) from donated organs. E. histolytica- or E. dispar-infected PCLS were analyzed at different post-infection times (0, 1, 3, 24 and 48 h) to evaluate the relation between tissue damage and the expression of genes associated with three factors: a) parasite survival (peroxiredoxin, superoxide dismutase and 70 kDa heat shock protein), b) parasite virulence (EhGal/GalNAc lectin, amoebapore, cysteine proteases and calreticulin), and c) the host inflammatory response (various cytokines)...
2017: PloS One
https://www.readbyqxmd.com/read/28770176/inhibition-of-plasmodium-hepatic-infection-by-antiretroviral-compounds
#13
Marta Machado, Margarida Sanches-Vaz, João P Cruz, António M Mendes, Miguel Prudêncio
Recent WHO guidelines on control of human immunodeficiency virus (HIV) call for the widespread use of antiretroviral (AR) therapy (ART) for people living with HIV. Given the considerable overlap between infections by HIV and Plasmodium, the causative agent of malaria, it is important to understand the impact of AR compounds and ART regimens on infections by malaria parasites. We undertook a systematic approach to identify AR drugs and ART drug combinations with inhibitory activity against the obligatory hepatic stage of Plasmodium infection...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28768535/developing-a-comprehensive-response-for-treatment-of-children-under-6%C3%A2-years-of-age-with-schistosomiasis-research-and-development-of-a-pediatric-formulation-of-praziquantel
#14
Jutta Reinhard-Rupp, Katharina Klohe
Schistosomiasis is a parasitic disease caused by blood flukes. The disease is caused by an inflammatory reaction to parasite eggs retained in the liver, bladder and reproductive organs. According to 2017 World Health Organization (WHO) estimates 220 million people are potentially infected, from which probably 10% are children under 6 years of age. The regular treatment approach of a single, oral dose of 40 mg/kg body weight with praziquantel however, is difficult for children under the age of 6, leaving them without a treatment option...
August 3, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28767981/protection-mediated-by-chemokine-cxcl10-in-balb-c-mice-infected-by-leishmania-infantum
#15
Webertty Mayk Eufrásio Figueiredo, Sayonara de Melo Viana, Dorotheia Teixeira Alves, Priscila Valera Guerra, Zirlane Castelo Branco Coêlho, Helene Santos Barbosa, Maria Jania Teixeira
BACKGROUND: Visceral leishmaniasis (VL) caused by Leishmania infantum is characterised by the loss of the ability of the host to generate an effective immune response. Chemokines have a direct involvement in the pathogenesis of leishmaniasis, causing a rapid change in the expression of these molecules during infection by Leishmania. OBJECTIVES: Herein, it was investigated the role of CXCL10 in controlling infection by L. infantum. METHODS: RAW 264...
August 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28765172/leishmania-donovani-inhibits-inflammasome-dependent-macrophage-activation-by-exploiting-the-negative-regulatory-proteins-a20-and-ucp2
#16
Anand Kumar Gupta, Kuntal Ghosh, Shreyasi Palit, Jayita Barua, Pijush K Das, Anindita Ukil
In visceral leishmaniasis, we found that the antileishmanial drug Amp B produces a higher level of IL-1β over the infected control. Moreover, administering anti-IL-1β antibody to infected Amp B-treated mice showed significantly less parasite clearance. Investigation revealed that Leishmania inhibits stimuli-induced expression of a multiprotein signaling platform, NLRP3 inflammasome, which in turn inhibits caspase-1 activation mediated maturation of IL-1β from its pro form. Attenuation of NLRP3 and pro-IL-1β in infection was found to result from decreased NF-κB activity...
August 1, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28764716/generation-of-transgenic-rodent-malaria-parasites-by-transfection-of-cell-culture-derived-merozoites
#17
Gesine Kaiser, Mariana De Niz, Paul-Christian Burda, Livia Niklaus, Rebecca Limenitakis Stanway, Volker Heussler
BACKGROUND: Malaria research is greatly dependent on and has drastically advanced with the possibility of genetically modifying Plasmodium parasites. The commonly used transfection protocol by Janse and colleagues utilizes blood stage-derived Plasmodium berghei schizonts that have been purified from a blood culture by density gradient centrifugation. Naturally, this transfection protocol depends on the availability of suitably infected mice, constituting a time-based variable. In this study, the potential of transfecting liver stage-derived merozoites was explored...
August 1, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28761483/road-killed-carnivores-illustrate-the-status-of-zoonotic-helminthes-in-caspian-sea-littoral-of-iran
#18
Aida Vafae Eslahi, Eshrat Beigom Kia, Iraj Mobedi, Meysam Sharifdini, Milad Badri, Gholamreza Mowlavi
BACKGROUND: Carnivore carcasses on the roads can be regarded as study materials in parasitology and eco-epidemiology. Stray carnivores such as dogs and cats are known to harbor so many different pathogens like zoonotic helminthes. The current investigation, apparent the status of the helminthic parasites found in road killed carnivores from different parts of Guilan Province north of Iran. METHODS: Fifty road killed carnivores including 27 stray dogs (Canis familiaris), 11 golden jackals (Canis aureus) and 12 stray cats (Felis catus) were collected from 21 locations of Guilan Province, during Apr to Nov 2015...
April 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28761460/relationships-between-oxidative-stress-liver-and-erythrocyte-injury-trace-elements-and-parasite-burden-in-sheep-naturally-infected-with-dicrocoelium-dendriticum
#19
Hadi Samadieh, Gholam-Reza Mohammadi, Mohsen Maleki, Hassan Borji, Mohammad Azizzadeh, Mohammad Heidarpour
BACKGROUND: The aim of this study was to investigate the role of oxidative stress in the pathology of ovine dicrocoeliasis. METHODS: During Dec 2013 - Oct 2014, seventy-two sheep (1-3 years) with liver dicrocoeliasis along with 47 healthy sheep were selected from animals admitted for slaughtering at slaughterhouse located in Neyshabour, Razavi Khorasan Province, Iran. RESULTS: In comparison to healthy control, the malondialdehyde (MDA) level and serum total antioxidant capacity were significantly higher in the parasitized group (P<0...
January 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28761236/primary-renal-echinococcosis
#20
Vishal V Ramteke, Nishant S Deshpande, Manish R Balwani, Charulata P Bawankule
Echinococcosis is a parasitic infection caused by the larval stage of a cestode Echinococcus granulosus and is endemic in sheep farming regions of developing countries. It manifests as hydatid cyst and most commonly is found in liver followed by lungs. Renal hydatid cyst is rare and amounts for 2% of all cases. There are no specific clinical manifestations, and hence diagnosis of renal hydatid disease is missed out easily without imaging. We report a case of 50-year-old female who had 6 months history of lower abdominal pain with hematuria, found to have right renal hydatid cyst on imaging which was treated with right nephrectomy with pre- and post-operative albendazole treatment...
July 2017: Indian Journal of Nephrology
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