keyword
MENU ▼
Read by QxMD icon Read
search

Liver, parasites

keyword
https://www.readbyqxmd.com/read/29160807/entamoeba-histolytica-under-oxidative-stress-what-countermeasure-mechanisms-are-in-place
#1
REVIEW
Erika Pineda, Doranda Perdomo
Entamoeba histolytica is the causative agent of human amoebiasis; it affects 50 million people worldwide and causes approximately 100,000 deaths per year. Entamoeba histolytica is an anaerobic parasite that is primarily found in the colon; however, for unknown reasons, it can become invasive, breaching the gut barrier and migrating toward the liver causing amoebic liver abscesses. During the invasive process, it must maintain intracellular hypoxia within the oxygenated human tissues and cellular homeostasis during the host immune defense attack when it is confronted with nitric oxide and reactive oxygen species...
November 21, 2017: Cells
https://www.readbyqxmd.com/read/29154994/evolutionary-epidemiology-of-schistosomiasis-linking-parasite-genetics-with-disease-phenotype-in-humans
#2
Tine Huyse, Nele A M Boon, Frederik Van den Broeck, Moustapha Mbow, Anurag Chaturvedi, Lynn Meurs, Filip A M Volckaert, Katja Polman
Here we assess the role of parasite genetic variation in host disease phenotype in human schistosomiasis by implementing concepts and techniques from environmental association analysis in evolutionary epidemiology. Schistosomiasis is a tropical disease that affects more than 200 million people worldwide and is caused by parasitic flatworms belonging to the genus Schistosoma. While the role of host genetics has been extensively studied and demonstrated, nothing is yet known on the contribution of parasite genetic variation to host disease phenotype in human schistosomiasis...
November 15, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/29153938/efficacy-and-safety-of-tribendimidine-versus-praziquantel-against-opisthorchis-viverrini-in-laos-an-open-label-randomised-non-inferiority-phase-2-trial
#3
Somphou Sayasone, Jennifer Keiser, Isabel Meister, Youthanavanh Vonghachack, Syda Xayavong, Kanpaseuth Senggnam, Khampheng Phongluxa, Jan Hattendorf, Peter Odermatt
BACKGROUND: Praziquantel is the only option for treatment of the liver fluke infection Opisthorchis viverrini. Tribendimidine could be an alternative drug. We aimed to assess the efficacy and safety of a single, oral dose of tribendimidine, compared with praziquantel administered in two doses, in participants with O viverrini infection. METHOD: We did an open-label, randomised, non-inferiority, phase 2 trial in children (8-14 years) and adolescents and adults (≥15 years) in Champasack province, southern Laos...
November 16, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29153587/advancing-research-models-and-technologies-to-overcome-biological-barriers-to-plasmodium-vivax-control
#4
REVIEW
Jennifer S Armistead, John H Adams
Malaria prevalence has declined in the past 10 years, especially outside of sub-Saharan Africa. However, the proportion of cases due to Plasmodium vivax is increasing, accounting for up to 90-100% of the malaria burden in endemic regions. Nonetheless, investments in malaria research and control still prioritize Plasmodium falciparum while largely neglecting P. vivax. Specific biological features of P. vivax, particularly invasion of reticulocytes, occurrence of dormant liver forms of the parasite, and the potential for transmission of sexual-stage parasites prior to onset of clinical illness, promote its persistence and hinder development of research tools and interventions...
November 16, 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/29149474/interventions-for-old-world-cutaneous-leishmaniasis
#5
REVIEW
Julio Heras-Mosteiro, Begoña Monge-Maillo, Mariona Pinart, Patricia Lopez Pereira, Emely Garcia-Carrasco, Pedro Campuzano Cuadrado, Ana Royuela, Irene Mendez Roman, Rogelio López-Vélez
BACKGROUND: Cutaneous leishmaniasis, caused by a parasitic infection, is considered one of the most serious skin diseases in many low- and middle-income countries. Old World cutaneous leishmaniasis (OWCL) is caused by species found in Africa, Asia, the Middle East, the Mediterranean, and India. The most commonly prescribed treatments are antimonials, but other drugs have been used with varying success. As OWCL tends to heal spontaneously, it is necessary to justify the use of systemic and topical treatments...
November 17, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29145875/re-visiting-the-detection-of-porcine-cysticercosis-based-on-full-carcass-dissections-of-naturally-taenia-solium-infected-pigs
#6
Mwelwa Chembensofu, K E Mwape, I Van Damme, E Hobbs, I K Phiri, M Masuku, G Zulu, A Colston, A L Willingham, B Devleesschauwer, A Van Hul, A Chota, N Speybroeck, D Berkvens, P Dorny, S Gabriël
BACKGROUND: Taenia solium is a neglected zoonotic parasite. The performances of existing tools for the diagnosis of porcine cysticercosis need further assessment, and their shortcomings call for alternatives. The objective of this study was to evaluate the performance of tongue palpation and circulating antigen detection for the detection of porcine cysticercosis in naturally infected pigs of slaughter age compared to full carcass dissections (considered the gold standard). Additionally, alternative postmortem dissection procedures were investigated...
November 16, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29143720/epidemiological-investigation-of-a-severe-rumen-fluke-outbreak-on-an-irish-dairy-farm
#7
James O'Shaughnessy, Andres Garcia-Campos, Conor G McAloon, Seamus Fagan, Theo de Waal, Maire McElroy, Micheal Casey, Barbara Good, Grace Mulcahy, John Fagan, Denise Murphy, Annetta Zintl
Although the rumen fluke, Calicophoron daubneyi is now very common and widespread throughout Western Europe, reports of clinical cases are still rare. This study explores the epidemiological background to a severe rumen fluke outbreak in 6-month-old heifers on a dairy farm in Ireland. Sequence analysis of the cytochrome oxidase subunit 1 (Cox1) gene of the rumen fluke metacercariae on pasture failed to identify predominant, possibly pathogenic subtypes. However, estimates of metacercarial load indicated that the animals were exposed to a daily dose of about 5334 C...
November 16, 2017: Parasitology
https://www.readbyqxmd.com/read/29141594/hepatic-paragonimiasis-in-a-15-month-old-girl-a-case-report
#8
Zongrong Gong, Zhicheng Xu, Chuanfen Lei, Chaomin Wan
BACKGROUND: Paragonimiasis, particularly hepatic paragonimiasis (HP), is a type of zoonotic parasitic disease rarely encountered in infants. There have been only a few reports of HP, and no case of HP has been reported in an infant. CASE PRESENTATION: A 15-month-old girl presented with persistent mild fever with a duration of 1 month, hepatomegaly, and low-density lesions in the right hepatic lobe on abdominal ultrasound and computer tomography. Pathological examination and serum antibody detection were performed to verify HP...
November 15, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/29132978/intensive-care-in-severe-malaria-report-from-the-task-force-on-tropical-diseases-by-the-world-federation-of-societies-of-intensive-and-critical-care-medicine
#9
REVIEW
Dilip R Karnad, Mohd Basri Mat Nor, Guy A Richards, Tim Baker, Pravin Amin
Severe malaria is common in tropical countries in Africa, Asia, Oceania and South and Central America. It may also occur in travelers returning from endemic areas. Plasmodium falciparum accounts for most cases, although P vivax is increasingly found to cause severe malaria in Asia. Cerebral malaria is common in children in Africa, manifests as coma and seizures, and has a high morbidity and mortality. In other regions, adults may also develop cerebral malaria but neurological sequelae in survivors are rare...
November 8, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29128645/kunitz-type-protease-inhibitor-as-a-vaccine-candidate-against-schistosomiasis-mansoni
#10
Shiwanthi L Ranasinghe, Mary Duke, Marina Harvie, Donald P McManus
OBJECTIVES: To develop a vaccine against schistosomiasis, which is a major challenge due to the complex life cycle of the causative schistosome parasite. METHODS: SmKI-1 is a 16kDa Kunitz type protease inhibitor present in the excretory/secretory products and tegument of adult worms and eggs of Schistosoma mansoni. Two independent vaccine trials were carried out in mice to determine the efficacy of rSmKI-1 in developing protective immunity. RESULTS: The results obtained showed reductions of 23-33% in adult worms, 28-31% in intestinal eggs, 33-39% in fecal eggs and 20-43% in liver eggs...
November 8, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29128045/recombinant-prohibitin-protein-of-leishmania-infantum-acts-as-a-vaccine-candidate-and-diagnostic-marker-against-visceral-leishmaniasis
#11
Daniel S Dias, Patrícia A F Ribeiro, Vívian T Martins, Daniela P Lage, Fernanda F Ramos, Anna L T Dias, Marcella R Rodrigues, Áquila S B Portela, Lourena E Costa, Rachel B Caligiorne, Bethina T Steiner, Miguel A Chávez-Fumagalli, Beatriz C S Salles, Thaís T O Santos, Julia A G Silveira, Danielle F Magalhães-Soares, Bruno M Roatt, Ricardo A Machado-de-Ávila, Mariana C Duarte, Daniel Menezes-Souza, Eduardo S Silva, Alexsandro S Galdino, Eduardo A F Coelho
Visceral leishmaniasis (VL) represents a serious public health problem, as Leishmania infantum is one of main disease causative agents in the Americas. In a previous immunoproteomic study, the prohibitin (PHB) protein was identified in L. infantum promastigote and amastigote extracts by antibodies in asymptomatic and symptomatic VL dog sera. This protein was found to be highly conserved between different Leishmania spp., but it presented a low identity with amino acid sequences of other organisms. The aim of the present study was to evaluate the cellular response induced by the recombinant PHB (rPHB) protein in BALB/c mice, as well as in PBMCs purified from untreated and treated VL patients, as well as to evaluate its protective efficacy against an infection by L...
November 9, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/29127992/leishmania-infantum-exerts-immunomodulation-in-canine-kupffer-cells-reverted-by-meglumine-antimoniate
#12
A Rodrigues, D Santos-Mateus, G Alexandre-Pires, A Valério-Bolas, M Rafael-Fernandes, M A Pereira, D Ligeiro, J de Jesus, R Alves-Azevedo, S Lopes-Ventura, M Santos, A M Tomás, I Pereira da Fonseca, G Santos-Gomes
Kupffer cells (KC) are the liver macrophage population that resides in the hepatic sinusoids and efficiently phagocyte pathogens by establishing an intimate contact with circulating blood. KC constitute the liver host cells in Leishmania infection, nevertheless little is described about their role, apart from their notable contribution in granulomatous inflammation. The present study aims to investigate how canine KC sense and react to the presence of Leishmania infantum promastigotes and amastigotes by evaluating the gene expression of specific innate immune cell receptors and cytokines, as well as the induction of nitric oxide and urea production...
December 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/29126422/changes-in-total-and-differential-leukocyte-counts-during-the-clinically-silent-liver-phase-in-a-controlled-human-malaria-infection-in-malaria-na%C3%A3-ve-dutch-volunteers
#13
Marlies E van Wolfswinkel, Marijke C C Langenberg, Linda J Wammes, Robert W Sauerwein, Rob Koelewijn, Cornelus C Hermsen, Jaap J van Hellemond, Perry J van Genderen
BACKGROUND: Both in endemic countries and in imported malaria, changes in total and differential leukocyte count during Plasmodium falciparum infection have been described. To study the exact dynamics of differential leukocyte counts and their ratios, they were monitored in a group of healthy non-immune volunteers in two separate Controlled Human Malaria Infection (CHMI) studies. METHODS: In two CHMI trials, CHMI-a and CHMI-b, 15 and 24 healthy malaria-naïve volunteers, respectively, were exposed to bites of infected mosquitoes, using the P...
November 10, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29118312/dynamics-of-liver-enzymes-in-rabbits-experimentally-infected-with-fasciola-sp-intermediate-form-from-japan
#14
Wipaporn Jarujareet, Kensuke Taira, Hong Kean Ooi
Dynamics of serum liver enzymes in rabbits experimentally infected with metacercariae of Fasciola sp. (intermediate form between Fasciola hepatica and F. gigantica) were monitored. Gradual increase of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were observed from 3 weeks post-inoculation (WPI) and peaked at 6 WPI, which corresponded well to the period of migration and development of juvenile fluke in the liver parenchyma and the time when the young adult flukes migrated to the bile duct...
November 9, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29116252/leptin-regulates-granzyme-a-pd-1-and-ctla-4-expression-in-t-cell-to-control-visceral-leishmaniasis-in-balb-c-mice
#15
Alti Dayakar, Sambamurthy Chandrasekaran, Jalaja Veronica, Vadloori Bharadwaja, Radheshyam Maurya
Visceral leishmaniasis (VL) is responsible for several deaths in malnourished children accompanied by diminished circulating leptin and impaired cell-mediated immunity. Typically, leptin deficiency is associated with the Th2 polarization that markedly coincides with the pathogenesis of VL. The aim of the present study was to unravel the prophylactic role of leptin in malnutrition-coupled VL mice. Interestingly, we observed that L. donovani infection itself reduces the serum leptin levels in malnutrition. Exogenous leptin restored severe body weight loss and parasite load in the spleen and liver of malnourished infected mice compared to controls...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29114489/chitinase-gene-based-analysis-of-the-genetic-variability-among-the-clinical-isolates-of-entamoeba-dispar-from-puducherry-india
#16
Selvarathinam Ajay Philips, Kumar Manochitra, Subhash Chandra Parija
Introduction: Amebiasis is known to be caused by the protozoan parasite Entamoeba histolytica. Entamoeba dispar is considered to be a sibling species of E. histolytica, as the two are phylogenetically closest. There are reports that certain strains of E. dispar isolated were capable of causing hepatic lesions in the experimental animal models. The intra-/inter-species genetic variation has been found to have profound implication in the invasiveness of the disease. Thus, studying polymorphism in E...
July 2017: Tropical Parasitology
https://www.readbyqxmd.com/read/29114137/gross-and-histopathological-alterations-associated-with-cystic-echinococcosis-in-small-ruminants
#17
Akeel Bashir Beigh, Mohmommad Maqbool Darzi, Samina Bashir, Bisma Kashani, Aazima Shah, Showkat Ahmad Shah
Hydatidosis, an important parasitic zoonoses is a major public health as well as economic concern throughout the world. A total of 2100, sheep (2052) and goats (48), slaughtered or spontaneously dead, from various areas of Kashmir valley were screened for the presence of hydatidosis. Out of 2100 cases, 85 were positive for hydatidosis. The frequently infected organs were lungs and liver. The liver was observed to be the most frequently infected organ with relative prevalence of 61.17% followed by lungs (38...
December 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/29114121/pathological-studies-on-helminth-parasitic-infection-in-mithun-bos-frontalis
#18
J K Chamuah, B Dutta, D Borkotoky
A pathological study was carried out in different helminth parasite infection organs in 110 animals during the period from 2010 to 2016. Histopathological examination of hydatid cysts in the liver, showed extensive fibrous connective tissue proliferation with eosinophilic and lymphocytic infiltration, in lung, parenchyma showed severe emphysema with infiltration of alveolar macrophages and lymphocytes infiltration. In Toxocara infection, polymorphonuclear infiltration in the sub-mucosa with hyper activity of goblet cells leading to occlusion of the gland was noted in the tissue sections...
December 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/29113597/antigenicity-immunogenicity-and-protective-efficacy-of-a-conserved-leishmania-hypothetical-protein-against-visceral-leishmaniasis
#19
Daniel S Dias, Vívian T Martins, Patrícia A F Ribeiro, Fernanda F Ramos, Daniela P Lage, Grasiele S V Tavares, Débora V C Mendonça, Miguel A Chávez-Fumagalli, Jamil S Oliveira, Eduardo S Silva, Dawidson A Gomes, Michele A Rodrigues, Mariana C Duarte, Alexsandro S Galdino, Daniel Menezes-Souza, Eduardo A F Coelho
In this study, a Leishmania hypothetical protein, LiHyS, was evaluated regarding its antigenicity, immunogenicity and protective efficacy against visceral leishmaniasis (VL). Regarding antigenicity, immunoblottings and an enzyme-linked immunosorbent assay using human and canine sera showed high sensitivity and specificity values for the recombinant protein (rLiHyS) in the diagnosis of VL. When evaluating the immunogenicity of LiHyS, which is possibly located in the parasite's flagellar pocket, proliferative assays using peripheral blood mononuclear cells from healthy subjects or VL patients showed a high proliferative index in both individuals, when compared to the results obtained using rA2 or unstimulated cultures...
November 8, 2017: Parasitology
https://www.readbyqxmd.com/read/29109850/liver-cystic-echinococcosis-and-human-host-immune-and-autoimmune-follow-up-a-review
#20
REVIEW
Nikica M Grubor, Katica D Jovanova-Nesic, Yehuda Shoenfeld
Cystic echinococcosis (CE) is an infectious disease caused by the larvae of parasite Echinococcus granulosus (E. granulosus). To successfully establish an infection, parasite release some substances and molecules that can modulate host immune functions, stimulating a strong anti-inflammatory reaction to carry favor to host and to reserve self-survival in the host. The literature was reviewed using MEDLINE, and an open access search for immunology of hydatidosis was performed. Accumulating data from animal experiments and human studies provided us with exciting insights into the mechanisms involved that affect all parts of immunity...
October 28, 2017: World Journal of Hepatology
keyword
keyword
97518
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"