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S Beckert, A Königsrainer
There is an increasing role of surgery even in metastatic tumor stages. In colorectal cancer patients with limited metastases, complete cytoreduction is able to offer long-term survival in synchronic as well as metachronic situations. In tumors of the upper gastrointestinal tract (UGIT), however, the impact of surgery in metastatic disease remains to be clarified. Even though several retrospective studies suggest prolonged survival, surgery is not recommended by the current German S3 guidelines for tumors of the UGIT...
May 17, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
Douglas M Oswald, Brian A Cobb
The glycobiology of the immune response is a topic that has garnered increased attention due to a number of key discoveries surrounding IgG function, the specificity of some broadly neutralizing anti-HIV antibodies, cancer immunoregulation by galectin molecules and others. This review is the opening article in a Special Edition of Cellular Immunology focused on glycoimmunology, and has the goal of setting the context for these articles by providing a mini-review of how glycans impact immunity. We also focus on some of the technological and methodological advances in the field of glycobiology that are being deployed to lower the barrier of entry into the glycosciences, and to more fully interrogate the glycome and its function...
April 25, 2018: Cellular Immunology
Melvin M Scheinman
No abstract text is available yet for this article.
May 11, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Anna Corrias
In his treatise on dreams Somniorum Synesiorum Libri IIII, published in 1562, the Italian Renaissance philosopher and physician Girolamo Cardano distinguishes between idola and visiones (or visa). Historians have discussed the reasons for such a distinction without taking into account Cardano's original theory of sense-perception. In this article I shall argue that, in order to interpret the meaning of idola and visiones in Cardano's theory of dreams, one should bear in mind his view that hearing is superior to sight and that while idola are essentially based on sound, visiones depend on images...
2018: Journal of the History of Ideas
Anat R Tambur
PURPOSE OF REVIEW: A renaissance for human leukocyte antigen (HLA) testing emerged with the understanding that donor-specific HLA antibodies play a significant role in long-term allograft survival. This renewed focus on donor/recipient histocompatibility led to a recent quest to decipher antibody responses or, as introduced into the transplantation lexicon, 'HLA-epitope matching'. RECENT FINDINGS: Whether matching is at the antigen or the epitope level, in-depth understanding of how histo-incompatibility leads to activation of an immune response is required...
May 9, 2018: Current Opinion in Organ Transplantation
L J Estcourt, D J Roberts
No abstract text is available yet for this article.
April 2018: Transfusion Medicine
Alireza Houshmand, Phil Donkiewicz, Ralf Smeets, Ole Jung, Mike Barbeck
With the emerging development and improvement of biomaterials, the application of ceramics in restorative medicine has experienced a renaissance. New production processes have reportedly helped to overcome unfavorable biomechanical characteristics of these materials, which lead to a wide application of zirconia as ground material for dental implants. Zirconia-based implants are biocompatible, demonstrate ability to osseointegrate and have a teeth-like color, rendering them to be an ideal replacement for titanium-based implant systems, which represent the current gold standard in implantology...
May 7, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Nathan D Ainspan, Walter Penk, Lisa K Kearney
This special issue of Psychological Services provides a glimpse of some of the most recent work in the arena of psychosocial interventions for military service members who are reintegrating into civilian society and becoming veterans. The psychological effects that can occur as members go through the military-to-civilian transition as they leave the military have been extensively recorded and treated. While psychosocial interventions have been utilized throughout history, we are seeing a new interest and recent renaissance in their use...
May 2018: Psychological Services
Roland Wohlgemuth
The small molecule domain of biological cellular systems is closely related to the synthesis and breakdown of larger molecules such as DNA, RNA, proteins or polysaccharides. Although the analysis, identification, characterization and synthesis of metabolites has a long history of milestone discoveries, it continues to be of great interest in the search for novel biological activities, metabolic pathways, diagnostic and therapeutic applications. Biologically active metabolites benefit from advantages in diffusion and transport for various interactions with proteins and nucleic acids and regulatory events...
April 30, 2018: Biotechnology Journal
Anna Marie Roos
No abstract text is available yet for this article.
April 30, 2018: Ambix
Victoria A Malik, Barbara Di Benedetto
Interactions among endothelial cells (EC) forming blood vessels and their surrounding cell types are essential to establish the blood-brain barrier (BBB), an integral part of the neurovascular unit (NVU). Research on the NVU has recently seen a renaissance to especially understand the neurobiology of vascular and brain pathologies and their frequently occurring comorbidities. Diverse signaling molecules activated in the near proximity of blood vessels trigger paracellular pathways which regulate the formation and stabilization of tight junctions (TJ) between EC and thereby influence BBB permeability...
2018: Frontiers in Molecular Neuroscience
Sakya S Sen, Herbert W Roesky
This feature article is intended to provide a background to the history of the isolation of silicon(ii) fluorides and the different synthetic methodologies used to generate them. Although first detected in the 1970s, the chemistry of silicon(ii) fluorides has not encountered serious research efforts for a rather long period of time. This is somewhat surprising given the fact that the chemistry of compounds with divalent silicon has undergone a renaissance during last three decades. Recently, the interest in silicon(ii) fluorides have been resparked with tremendous progress being achieved in this area, in particular, with respect to their synthesis and structural characterisation...
April 26, 2018: Chemical Communications: Chem Comm
Richard Wennberg, Lady D Ladino, José F Téllez-Zenteno
No abstract text is available yet for this article.
April 10, 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
Z C Gao
No abstract text is available yet for this article.
April 12, 2018: Chinese Journal of Tuberculosis and Respiratory Diseases
Claus-Christian Carbon, Alexander Pastukhov
Art history claims that Western art shows light from the top left, which has been repeatedly shown with narrow image sets and simplistic research methods. Here we employed a set of 10,000 pictures for which participants estimated the direction of light plus their confidence of estimation. From 1420 A.D., the onset of Early Renaissance, until 1900 A.D., we revealed a clear preference for painting light from the top left-within the same period, we observed the highest confidence in such estimations of the light source...
2018: Frontiers in Psychology
Thomas Häusler
Phage therapy has an intriguing history. It was widely used from the 1920s until the 1940s. After this period, it was nearly completely forgotten in the Western world, while it continued to be used in the Soviet part of the globe. The study of the history of phage therapy provides valuable input into the present development of the field. Science journalists uncovered much of this history and played an important role in the communication of phage therapy after the fall of the Soviet Union, when it came to the attention of Western researchers and doctors...
April 20, 2018: Viruses
Ahmed S BaHammam, Aljohara S Almeneessier, Seithikurippu R Pandi-Perumal
Islamic civilization between the 7th and the 15th centuries made great contributions to the development of science and medicine, and discoveries made during this time formed the basis for the emergence of the European Renaissance. Muslims view sleep as one of the great signs of Allāh , and a number of Muslim scholars studied and wrote on sleep and dreams. However, Muslim scholars' contributions to this topic have not been adequately represented in modern scholarship. Islamic scholars did far more than simply act as the preservers of the antiquity and Greek knowledge, but rather laid significant foundation, translation, interpretation, and transference of knowledge and experience, and have contributed original works in many fields of science and medicine including sleep...
April 2018: Annals of Thoracic Medicine
Emilia Palazzotto, Tilmann Weber
Natural products produced by microorganisms represent the main source of bioactive molecules. The development of high-throughput (omics) techniques have importantly contributed to the renaissance of new antibiotic discovery increasing our understanding of complex mechanisms controlling the expression of biosynthetic gene clusters (BGCs) encoding secondary metabolites. In this context this review highlights recent progress in the use and integration of 'omics' approaches with focuses on genomics, transcriptomics, proteomics metabolomics meta-omics and combined omics as powerful strategy to discover new antibiotics...
April 12, 2018: Current Opinion in Microbiology
Venkatachalam Raveenthiran
Circumcision is the oldest surgical operation known to mankind. It probably originated as a less radical form of genital mutilation inflicted on prisoners of war. Over time it was adopted by the Egyptian priesthood and nobility, perhaps inspired by the mythology of Osiris. In turn, circumcision became part of the Jewish and Muslim religious cultures. In contrast, ancient Greeks valued an intact prepuce, as evident from the nude figures of Renaissance art. In the 19th century, circumcision was touted as a treatment for excessive masturbation, seizures, epilepsy, and paraplegia...
March 8, 2018: Journal of Pediatric Surgery
Zarafshan Bader, Akbar Waheed, Salman Bakhtiar, Imrana Maqsood Khan
The alarming rise in the rate of multi drug resistant, life threatening gram negative infections has brought renaissance in the use of Colistin for last two decades. The major constraint in its utilization is its nephrotoxicity. Therefore it is being underused which is favoring the development of resistance. This study assesses the prevention of nephrotoxicity associated with high and low toxic doses of Colistin by alpha-tocopherol. Thirty rabbits were randomly divided into five groups. Baseline serum urea, creatinine and electrolytes were estimated...
March 2018: Pakistan Journal of Pharmaceutical Sciences
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