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https://www.readbyqxmd.com/read/28934855/review-of-toxicology-in-the-middle-ages-and-renaissance-toxicology-in-the-middle-ages-and-renaissance-edited-by-philip-wexler-academic-press-london-uk-2017-192-pp-39-95-paperback-6-%C3%A3-0-4-%C3%A3-9-in-isbn-13-978-0128095546
#1
https://www.readbyqxmd.com/read/28933919/re-chinese-tcm-renaissance-and-the-global-movement-for-integrative-health-and-medicine-by-weeks-j-altern-complement-med-2017-23-79-81
#2
Arthur Yin Fan, Sarah Faggert
No abstract text is available yet for this article.
September 21, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28925992/efficacy-of-combining-ing4-and-trail-genes-in-cancer-targeting-gene-virotherapy-strategy-first-evidence-in-preclinical-hepatocellular-carcinoma
#3
A G El-Shemi, A M Ashshi, E Oh, B-K Jung, M Basalamah, A Alsaegh, C-O Yun
Current treatments of hepatocellular carcinoma (HCC) are ineffective and unsatisfactory in many aspects. Cancer-targeting gene virotherapy using oncolytic adenoviruses (OAds) armed with anticancer genes has shown efficacy and safety in clinical trials. Nowadays, both inhibitor of growth 4 (ING4); as a multimodal tumor suppressor gene, and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL); as potent-apoptosis inducing gene, are experiencing a renaissance in cancer gene therapy. Herein we investigated the antitumor activity and safety of mono-and combined therapy with OAds armed with ING4 (Ad-ΔB/ING4) and TRAIL (Ad-ΔB/TRAIL) gene, respectively, on preclinical models of human HCC...
September 19, 2017: Gene Therapy
https://www.readbyqxmd.com/read/28921874/polaronic-charge-carrier-lattice-interaction-in-lead-halide-perovskites
#4
Christoph Wolf, Young-Hoon Kim, Himchan Cho, Tae-Woo Lee
Almost ten years after the renaissance of the popular perovskite-type semiconductors based on lead-salts with general formula AMX3 (A=organic or inorganic cation, M=divalent metal, X=halide), many facets of photophysics continue to puzzle researchers. In this review, we shed some light on the low mobilities of charge carriers in lead-halide perovskites with special focus on the lattice properties at non-zero temperature. The polar and soft lattice leads to pronounced electron-phonon coupling, limiting carrier mobility and retarding recombination...
September 18, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28921410/vyacheslav-slava-klimov-1945-2017-a-scientist-par-excellence-a-great-human-being-a-friend-and-a-renaissance-man
#5
Suleyman I Allakhverdiev, Sergey K Zharmukhamedov, Margarita V Rodionova, Vladimir A Shuvalov, Charles Dismukes, Jian-Ren Shen, James Barber, Göran Samuelsson, Govindjee
Vyacheslav Vasilevich (V.V.) Klimov (or Slava, as most of us called him) was born on January 12, 1945 and passed away on May 9, 2017. He began his scientific career at the Bach Institute of Biochemistry of the USSR Academy of Sciences (Akademy Nauk (AN) SSSR), Moscow, Russia, and then, he was associated with the Institute of Photosynthesis, Pushchino, Moscow Region, for about 50 years. He worked in the field of biochemistry and biophysics of photosynthesis. He is known for his studies on the molecular organization of photosystem II (PSII)...
September 18, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/28910226/the-bacterial-renaissance-a-supply-side-answer-to-the-icarus-paradox-of-antibiotic-usage-undermining-its-own-usefulness
#6
Gurney Fields Pearsall
No abstract text is available yet for this article.
January 2017: Journal of Legal Medicine
https://www.readbyqxmd.com/read/28901969/disorders-of-consciousness-after-severe-brain-injury-therapeutic-options
#7
Caroline Schnakers, Martin M Monti
PURPOSE OF REVIEW: Very few options exist for patients who survive severe traumatic brain injury but fail to fully recover and develop a disorder of consciousness (e.g. vegetative state, minimally conscious state). RECENT FINDINGS: Among pharmacological approaches, Amantadine has shown the ability to accelerate functional recovery. Although with very low frequency, Zolpidem has shown the ability to improve the level of consciousness transiently and, possibly, also in a sustained fashion...
September 9, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28898658/phyllotaxis
#8
Cris Kuhlemeier
Leaves and flowers are arranged in regular patterns around the stem of a plant, a phenomenon known as phyllotaxis. Different arrangements occur, such as distichous, decussate or spiral (Figure 1). Most prevalent in nature are spirals in which the average divergence angles between successive organs are close to 137.5°, the so-called 'golden angle'. It is this exact number that has given phyllotaxis its special flavor as a quantitative developmental problem, and over the centuries, it has enjoyed the attention of scientists far beyond botany...
September 11, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28895843/historical-perspective-on-the-current-renaissance-for-hematopoietic-stem-cell-gene-therapy
#9
REVIEW
Donald B Kohn
Gene therapy using hematopoietic stem cells (HSC) has developed over the past 3 decades, with progressive improvements in the efficacy and safety. Autologous transplantation of HSC modified with murine gammaretroviral vectors first showed clinical benefits for patients with several primary immune deficiencies, but some of these patients suffered complications from vector-related genotoxicity. Lentiviral vectors have been used recently for gene addition to HSC and have yielded clinical benefits for primary immune deficiencies, metabolic diseases, and hemoglobinopathies, without vector-related complications...
October 2017: Hematology/oncology Clinics of North America
https://www.readbyqxmd.com/read/28890458/the-life-of-a-renaissance-gunmaker-bonaccorso-ghiberti-and-the-development-of-florentine-artillery-in-the-late-fifteenth-century
#10
Fabrizio Ansani
This article examines the technological development of artillery production in Florence during the last two decades of the fifteenth century, before and after the assimilation of the most efficient French ordnance into Italian warfare. The study starts from the notes, drawings, accounts, and guns produced by Bonaccorso di Vettorio Ghiberti (1451-1516), the heir of the foundry of his illustrious ancestor Lorenzo di Cione (1378-1455). Data have been collected from the historical archives of the Istituto degli Innocenti, from the Biblioteca Nazionale Centrale of Florence, and from the Florentine State Archive...
2017: Technology and Culture
https://www.readbyqxmd.com/read/28888913/the-renaissance-of-lipoprotein-a-brave-new-world-for-preventive-cardiology
#11
REVIEW
Katrina L Ellis, Michael B Boffa, Amirhossein Sahebkar, Marlys L Koschinsky, Gerald F Watts
Lipoprotein(a) [Lp(a)] is a highly heritable cardiovascular risk factor. Although discovered more than 50 years ago, Lp(a) has recently re-emerged as a major focus in the fields of lipidology and preventive cardiology owing to findings from genetic studies and the possibility of lowering elevated plasma concentrations with new antisense therapy. Data from genetic, epidemiological and clinical studies have provided compelling evidence establishing Lp(a) as a causal risk factor for atherosclerotic cardiovascular disease...
September 6, 2017: Progress in Lipid Research
https://www.readbyqxmd.com/read/28886995/improving-oral-bioavailability-of-cyclic-peptides-by-n-methylation
#12
Andreas F B Räder, Florian Reichart, Michael Weinmüller, Horst Kessler
The renaissance of peptides in pharmaceutical industry results from their importance in many biological functions. However, low metabolic stability and the lack of oral availability of most peptides is a certain limitation. Whereas metabolic instability may be often overcome by development of small cyclic peptides containing d-amino acids, the very low oral availability of most peptides is a serious limitation for some medicinal applications. The situation is complicated because a twofold optimization - biological activity and oral availability - is required to overcome this problem...
August 31, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28882900/adipocyte-liver-kinase-b1-suppresses-beige-adipocyte-renaissance-through-class-iia-histone-deacetylase-4
#13
Yangmeng Wang, Esther Paulo, Dongmei Wu, Yixuan Wu, Wendong Huang, Ajay Chawla, Biao Wang
Uncoupling protein 1(+) (UCP1(+)) beige adipocytes are dynamically regulated by environment in rodents and humans; cold induces formation of beige adipocytes, while warm temperature and nutrient excess lead to their disappearance. Beige adipocytes can form through de novo adipogenesis, however how "beigeing" characteristics are maintained afterwards is largely unknown. Here we show that beige adipocytes formed postnatally in subcutaneous inguinal white adipose tissue (iWAT) lost thermogenic gene expression and multilocular morphology at adult stage, but cold restored their "beigeing" characteristics, a phenomenon termed as beige adipocyte renaissance...
September 7, 2017: Diabetes
https://www.readbyqxmd.com/read/28879606/history-of-clubfoot-treatment-part-iii-twentieth-century-back-to-the-future
#14
REVIEW
Philippe Hernigou
Clubfoot is one of the most common congenital orthopaedic anomalies and was described by Hippocrates in the year 400 BC. From manipulation in antiquity to splint and plaster in the Renaissance the treatment had improved before tenotomy. Many surgical treatments were tested during the nineteenth and twentieth centuries and will be explained in this manuscript; however, the pathology still continues to challenge the paediatric orthopedic surgeon as it has a notorious tendency to relapse, irrespective of whether the foot is treated with conservative or operative means...
September 6, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28871575/inert-gas-washout-background-and-application-in-various-lung-diseases
#15
Jakob Usemann, Sophie Yammine, Florian Singer, Philipp Latzin
Multiple breath inert gas washout (MBW) is a lung function technique to measure ventilation inhomogeneity. The technique was developed more than 60 years ago, but not much used for many decades. Technical improvements, easy protocols and higher sensitivity compared with standard lung function tests in some disease groups have led to a recent renaissance of MBW. The lung clearance index (LCI) is a common measure derived from MBW tests, and offers information on lung pathology complementary to that from conventional lung function tests such as spirometry...
September 5, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28864573/metabolomics-in-yeast
#16
Amy A Caudy, Michael Mülleder, Markus Ralser
Budding yeast has from the beginning been a major eukaryotic model for the study of metabolic network structure and function. This is attributable to both its genetic and biochemical capacities and its role as a workhorse in food production and biotechnology. New inventions in analytical technologies allow accurate, simultaneous detection and quantification of metabolites, and a series of recent findings have placed the metabolic network at center stage in the physiology of the cell. For example, metabolism might have facilitated the origin of life, and in modern organisms it not only provides nutrients to the cell but also serves as a buffer to changes in the cellular environment, a regulator of cellular processes, and a requirement for cell growth...
September 1, 2017: Cold Spring Harbor Protocols
https://www.readbyqxmd.com/read/28851722/microtubule-organization-dynamics-and-functions-in-differentiated-cells
#17
REVIEW
Andrew Muroyama, Terry Lechler
Over the past several decades, numerous studies have greatly expanded our knowledge about how microtubule organization and dynamics are controlled in cultured cells in vitro However, our understanding of microtubule dynamics and functions in vivo, in differentiated cells and tissues, remains under-explored. Recent advances in generating genetic tools and imaging technologies to probe microtubules in situ, coupled with an increased interest in the functions of this cytoskeletal network in differentiated cells, are resulting in a renaissance...
September 1, 2017: Development
https://www.readbyqxmd.com/read/28826951/hybrid-ms-nmr-methods-on-the-prioritization-of-natural-products-applications-in-drug-discovery
#18
REVIEW
Nelson G M Gomes, David M Pereira, Patrícia Valentão, Paula B Andrade
The discovery of new chemical entities from natural sources has been historically driven by the biological activity observed in crude extracts or by the significant abundance of secondary metabolites, through a laborious workflow, frequently culminating on the re-isolation of known compounds. This high rate of rediscovery was one of the main contributing factors leading to the decreased interest in natural products from pharmaceutical companies and academic research groups until very recently. Largely driven by the technological advances in analytical instrumentation, mainly mass spectrometry (MS) and nuclear magnetic resonance (NMR), a renaissance on natural products research and associated drug discovery programs is being witnessed...
July 31, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28820884/let-s-rise-up-to-unite-taxonomy-and-technology
#19
Holly M Bik
What do you think of when you think of taxonomy? An 18th century gentlemen in breeches? Or perhaps botany drawings hung on the walls of a boutique hotel? Such old-fashioned conceptions to the contrary, taxonomy is alive today although constantly struggling for survival and recognition. The scientific community is losing valuable resources as taxonomy experts age and retire, and funding for morphological studies and species descriptions remains stagnant. At the same time, organismal knowledge (morphology, ecology, physiology) has never been more important: genomic studies are becoming more taxon focused, the scientific community is recognizing the limitations of traditional "model" organisms, and taxonomic expertise is desperately needed to fight against global biodiversity declines resulting from human impacts...
August 2017: PLoS Biology
https://www.readbyqxmd.com/read/28820070/muc1-story-great-expectations-disappointments-and-the-renaissance
#20
Mikhail A Rubtsov, Marina S Syrkina, Yegor S Vassetzky
In the course of studying human mucin MUC1, an attitude towards this molecule has been changing time and again. Initially, the list of presumable functions of MUC1 was restricted to protecting and lubricating epithelium. To date, it is assumed to play an important role in cell signaling as well as in all stages of oncogenesis, from malignant cell transformation to tumor dissemination. The story of MUC1 is full of hopes and disappointments. However, the scientific interest to MUC1 has never waned, and the more profoundly it has been investigated, the clearer its hidden potential turned to be disclosed...
August 17, 2017: Current Medicinal Chemistry
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