Luo-Yuan Xia, Xue-Feng Wang, Xiao-Ming Cui, Yi-Ming Zhang, Zhen-Fei Wang, En-Tao Li, Chang-Fa Fan, Ke Song, Yuan-Guo Li, Run-Ze Ye, Fang-Xu Li, Dai-Yun Zhu, Jie Zhang, Zhuang-Zhuang Shi, Ming-Zhu Zhang, Liang-Jing Li, Shi-Jing Shen, Song Jin, Ya-Wei Zhang, Wei-Guang Fu, Lin Zhao, Wen-Hao Wang, Tie-Cheng Wang, You-Chun Wang, Jia-Fu Jiang, Yan-Ling Hu, Na Jia, Yu-Wei Gao, Wu-Chun Cao
Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins, showing a potential threat to humans. Here we report the infectivity and pathogenicity of the SARS-CoV-2-related virus, PCoV-GX/P2V, which was isolated from a Malayan pangolin (Manis javanica). PCoV-GX/P2V could grow in human hepatoma, colorectal adenocarcinoma cells, and human primary nasal epithelial cells. It replicated more efficiently in cells expressing human angiotensin-converting enzyme 2 (hACE2) as SARS-CoV-2 did...
March 8, 2024: Science China. Life Sciences