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https://www.readbyqxmd.com/read/29736391/the-effects-of-antimicrobial-peptide-nal-p-113-on-inhibiting-periodontal-pathogens-and-improving-periodontal-status
#1
Hongyan Wang, Lisi Ai, Yu Zhang, Jyawei Cheng, Huiyuan Yu, Chen Li, Dongmei Zhang, Yaping Pan, Li Lin
Periodontal disease consists of chronic gingival inflammation characterized by both degradation of the periodontal connective tissue and alveolar bone loss. Drug therapy is used as an auxiliary treatment method in severe chronic periodontitis, aggressive periodontitis, and periodontitis-associated systemic disease. Nal-P-113, a modified antimicrobial peptide, specifically replaces the histidine residues of P-113 with the bulky amino acid β -naphthylalanine, and our previous studies have verified that this novel peptide is not toxic to the human body within a certain concentration range...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29680842/one-or-two-ligatures-inducing-periodontitis-are-sufficient-to-cause-fatty-liver
#2
L-S Pessoa, F-R Pereira-da Silva, E-H-P Alves, L-F-C Franca, D di Lenardo, J-S Carvalho, V-B-D Martins, F-B-M Sousa, K-O Drumond, J-V-R Medeiros, J-S de Oliveira, D-F-P Vasconcelos
BACKGROUND: Periodontitis is a chronic disease that due to an intense inflammatory response triggers systemic changes such as hepatic alterations. This study aimed to compare hepatic damage in rats that received experimental periodontitis at one or two periodontal sites with ligatures. MATERIAL AND METHODS: Eighteen rats were separated into three groups: control, without ligature; periodontitis 1, with one ligature; and periodontitis 2, with two ligatures. The following parameters were assessed: gingival bleeding index, probing pocket depth, tooth mobility, alveolar bone loss, malondialdehyde (MDA) and myeloperoxidase (MPO) activity in periodontal tissue; histopathological evaluation of hepatic tissue (steatosis score); glutathione levels (GSH), MDA, MPO, cholesterol and triglycerides in the liver; and serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST)...
April 22, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29652608/immunomodulatory-role-of-stem-cell-from-human-exfoliated-deciduous-teeth-on-periodontal-regeneration
#3
Xianling Gao, Zongshan Shen, Meiliang Guan, Qiting Huang, Lingling Chen, Wei Qin, Xiaohu Ge, Haijia Chen, Yin Xiao, Zhengmei Lin
Periodontitis is initiated by the infection of periodontal bacteria and subsequent tissue inflammation due to immunoreaction, eventually leading to periodontal apparatus loss. Stem cells from human exfoliated deciduous teeth (SHEDs) have exhibited beneficial characteristics in dental tissue regeneration. However, the immunomodulatory functions of SHEDs have not been elucidated in the context of periodontitis treatment. In this study, we investigated the potential immunomodulatory effects of SHEDs on experimental periodontitis and demonstrated that multi-dose delivery of SHEDs led to periodontal tissue regeneration...
March 20, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29602626/intra-alveolar-epsilon-aminocaproic-acid-for-the-control-of-post-extraction-bleeding-in-anticoagulated-patients-randomized-clinical-trial
#4
R V da Silva, T B Gadelha, R R Luiz, S R Torres
The aim of this study was to compare the effectiveness of the intra-alveolar administration of epsilon-aminocaproic acid (EACA) and daily gentle rinsing with EACA mouthwash with that of routine postoperative procedures for the control of bleeding after tooth extraction in anticoagulated patients. A randomized clinical trial was conducted involving 52 patients submitted to 140 tooth extractions, assigned randomly to two groups. The intervention group was treated with intra-alveolar administration of EACA immediately after surgery and gentle rinsing with EACA mouthwash during the postoperative period...
March 27, 2018: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29561395/suffocation-from-balloon-bronchoplasty
#5
Jorge L Morales-Estrella, Michael Machuzak, Bohdan Pichurko, Hanine Inaty, Atul C Mehta
Negative pressure pulmonary edema is a well-described complication of upper airway obstruction. However, the simultaneous occurrence of blood-stained secretions and petechial tracheobronchial hemorrhage are rarely recognized and a potential complication of transient intentional occlusion of the airways. We described a case of "hemorrhagic bronchial mucosa syndrome" and asymptomatic blood-tinged pulmonary edema after balloon bronchoplasty for a concentric tracheal stenosis using a flexible bronchoscopy...
April 2018: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/29557797/postoperative-maxillary-cyst-developing-after-sinus-augmentation-for-dental-implants-a-rare-case-report
#6
Yoon-Sic Han
Sinus augmentation is a routine procedure performed in patients presenting with severe atrophy of the posterior maxillary alveolar ridge who seek dental implant surgery. Although this strategy is successful in large part, complications such as maxillary sinusitis, antral bleeding, resorption of graft material, infection, failure of implant installation, and oroantral fistula formation are documented on occasion. However, reports of postoperative maxillary cyst (POMC) arising after sinus augmentation are rare...
March 19, 2018: Implant Dentistry
https://www.readbyqxmd.com/read/29557269/acute-diffuse-alveolar-haemorrhage-accompanied-by-gastrointestinal-bleeding-in-a-patient-with-serious-systemic-lupus-erythematosus-a-case-report
#7
Jing Du, Ying Wang, Yan-Chun Li, Tong-Tong Wang, Yong-Lie Zhou, Zhen-Hua Ying
Systemic lupus erythematosus (SLE) is an autoimmune disease that affects many organs, but multisystem dysfunction is rare. Here, we report a case of a 29-year-old woman who was initially diagnosed with SLE complications including lupus nephritis, lupus encephalopathy, renal hypertension, thrombocytopenia, anaemia and hyperkalaemia. She recovered following treatment with high dose methylprednisolone, intravenous immunoglobulin (IVIG) and continuous renal replacement therapy (CRRT). However, a few days after hospital discharge, she developed gastrointestinal bleeding...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29527996/causes-of-hemoptysis-in-renal-transplant-patients
#8
Irem Serifoglu, Balam Er Dedekarginoglu, Ebru Hatice Ayvazoglu Soy, Gaye Ulubay, Mehmet Haberal
OBJECTIVES: Hemoptysis is a symptom that can be caused by airway disease, pulmonary parenchymal disease, or pulmonary vascular disease, or it can be idiopathic. Infection is the most common cause of hemoptysis, accounting for 60% to 70% of cases. Hemoptysis is also an initial symptom of diffuse alveolar hemorrhage syndrome, although it may be absent at presentation in one-third of patients. Diffuse alveolar hemorrhage is characterized by disruption of the alveolar-capillary basement membranes because of either injury or inflammation of the arterioles, venules, or capillaries, resulting in bleeding in alveolar spaces...
March 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29498126/effects-of-lateral-bone-augmentation-procedures-on-peri-implant-health-or-disease-a-systematic-review-and-meta-analysis
#9
REVIEW
Ignacio Sanz-Sánchez, Ana Carrillo de Albornoz, Elena Figuero, Frank Schwarz, Ronald Jung, Mariano Sanz, Daniel Thoma
OBJECTIVES: This systematic review evaluated the evidence on the effect of the interventions aimed for lateral ridge augmentation (both simultaneously with implant placement or as a staged procedure) on peri-implant health or disease. METHODS: A protocol was developed to answer the following PICO question: "In patients with horizontal alveolar ridge deficiencies (population), what is the effect of lateral bone augmentation procedures (intervention and comparison) on peri-implant health (outcome)?" Included studies were randomised controlled trials or controlled clinical trials with a follow-up of at least 12 months after implant loading...
March 2018: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/29474926/the-fibrogenic-actions-of-the-coagulant-and-plasminogen-activation-systems-in-pulmonary-fibrosis
#10
REVIEW
Michael Schuliga, Christopher Grainge, Glen Westall, Darryl Knight
Fibrosis causes irreversible damage to lung structure and function in restrictive lung diseases such as idiopathic pulmonary fibrosis (IPF). Extravascular coagulation involving fibrin formation in the intra-alveolar compartment is postulated to have a pivotal role in the development of pulmonary fibrosis, serving as a provisional matrix for migrating fibroblasts. Furthermore, proteases of the coagulation and plasminogen activation (plasminergic) systems that form and breakdown fibrin respectively directly contribute to pulmonary fibrosis...
April 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29463174/cumulative-use-of-salivary-markers-with-an-adaptive-design-improves-detection-of-periodontal-disease-over-fixed-biomarker-thresholds
#11
Ulvi Kahraman Gürsoy, Pirkko J Pussinen, Veikko Salomaa, Sanna Syrjäläinen, Eija Könönen
OBJECTIVE: Aim was to analyze the diagnostic ability of cumulative risk score (CRS), which uses salivary levels of Porphyromonas gingivalis, interleukin (IL)-1β, and matrix metalloproteinase (MMP)-8 in an adaptive design, compared to previously reported thresholds of each marker alone. MATERIALS AND METHODS: Oral and general health information of 463 participants were included in the analysis. Having the percentage of bleeding on probing (BOP) > 25%, having at least two sites with probing pocket depth (PPD) of 4-5 mm or having at least one tooth with alveolar bone loss (ABL) of at least 1/3 of the root length were accepted as outcome variables...
February 20, 2018: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/29430453/anticoagulant-therapy-in-acute-respiratory-distress-syndrome
#12
REVIEW
Marta Camprubí-Rimblas, Neus Tantinyà, Josep Bringué, Raquel Guillamat-Prats, Antonio Artigas
Acute respiratory distress syndrome (ARDS) presents a complex pathophysiology characterized by pulmonary activated coagulation and reduced fibrinolysis. Despite advances in supportive care of this syndrome, morbidity and mortality remains high, leading to the need of novel therapies to combat this disease. Focus these therapies in the inhibition of ARDS development pathophysiology is essential. Beneficial effects of anticoagulants in ARDS have been proved in preclinical and clinical trials, thanks to its anticoagulant and anti-inflammatory properties...
January 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29422870/patients-with-chronic-obstructive-pulmonary-disease-suffer-from-worse-periodontal-health-evidence-from-a-meta-analysis
#13
Quan Shi, Bin Zhang, Helin Xing, Shuo Yang, Juan Xu, Hongchen Liu
Background and Objective: It is widely accepted that there is an association between chronic obstructive pulmonary disease (COPD) and periodontitis. However, whether the periodontal status of the COPD patients is worse than that of the non-COPD subjects is seldom assessed. The findings currently available are inconsistent, some even contradictory. Therefore, we performed this meta-analysis to compare the periodontal health status of COPD patients and non-COPD subjects. Methods: PubMed and Embase were searched for all of the eligible studies which comparing the periodontal status between COPD patients and non-COPD subjects...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29374925/-influences-of-ulinastatin-on-acute-lung-injury-and-time-phase-changes-of-coagulation-parameters-in-rats-with-burn-blast-combined-injuries
#14
W Liu, J K Chai
Objective: To explore the influences of ulinastatin on acute lung injury and time phase changes of coagulation parameters in rats with severe burn-blast combined injuries. Methods: One hundred and ninety-two Sprague-Dawley rats were divided into pure burn-blast combined injury group, ulinastatin+ burn-blast combined injury group, and sham injury group according to the random number table, with 64 rats in each group. Two groups of rats with combined burn-blast injuries were inflicted with moderate blast injuries with the newly self-made explosive device...
January 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29351042/secondary-alveolar-bone-grafting-in-patients-born-with-unilateral-cleft-lip-and-palate-a-20-year-follow-up
#15
Fatemeh Jabbari, Laila Wiklander, Erika Reiser, Andreas Thor, Malin Hakelius, Daniel Nowinski
OBJECTIVE: To identify factors of oral health important for the final outcome, after secondary alveolar bone grafting in patients born with unilateral cleft lip and palate and compare occlusal radiographs with cone beam computed tomography (CBCT) in assessment of alveolar bone height. DESIGN: Observational follow-up study. SETTING: Cleft Lip and Palate Team, Craniofacial Center, Uppsala University Hospital, Sweden. PATIENTS: 40 nonsyndromic, Caucasian patients with unilateral complete cleft lip and palate...
February 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29339679/a-rare-complication-in-a-patient-taking-rivaroxaban-alveolar-hemorrhage
#16
Salih Kılıç, Erhan Saraçoğlu, Gülin Alkan
Alveolar hemorrhage (AH) is a heterogeneous clinical syndrome with a high mortality rate that is characterized by extensive bleeding into the alveolar spaces. AH usually develops secondary to immunological disease and, less frequently, to drug use. Presently described is the case of an 86-year-old woman with AH who had been using rivaroxaban for 6 months.
January 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29320751/uterine-rhabdomyosarcoma-in-adults
#17
Andre Pinto, Ryan M Kahn, Andrew E Rosenberg, Brian Slomovitz, Charles Matthew Quick, Michella K Whisman, Marilyn Huang
Rhabdomyosarcoma (RMS) is an aggressive mesenchymal tumor most commonly diagnosed in the pediatric population, and when occurring in adults, tends to develop in the deep soft tissue of the limbs. Primary uterine RMS comprises an even more restricted subset, with little known or reported when compared to most other gynecologic sarcomas. Our goal with this study was to retrospectively evaluate cases from two academic institutions and describe the main histopathologic findings of this rare gynecologic malignancy...
January 7, 2018: Human Pathology
https://www.readbyqxmd.com/read/29284945/comparison-of-marginal-periosteal-pedicle-graft-and-bioactive-glass-with-platelet-rich-fibrin-and-bioactive-glass-in-the-treatment-of-intrabony-defects-a-clinicoradiographic-study
#18
M S Yasaswini, K V Prabhakara Rao, P Tanuja, Narendra Reddy Motakatla
Introduction and Objectives: The objective of the study was to compare clinically and radiographically the regenerative potential of marginal periosteal pedicle graft (MPPG) or platelet-rich fibrin (PRF) with a bioactive glass in the treatment of two- and three-wall intrabony defects. Methods: A total of 28 sites (bilateral or contralateral infrabony defects) from 14 patient were treated with MPPG (Experimental site A) and the other site was treated with PRF (Experimental site B)...
November 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29273073/pulmonary-tumor-thrombotic-microangiopathy-successfully-treated-with-corticosteroids-a-case-report
#19
Shinichi Miyazaki, Takuya Ikeda, Genshi Ito, Masahide Inoue, Keiji Nara, Yuko Nishinaga, Yoshinori Hasegawa
BACKGROUND: Pulmonary tumor thrombotic microangiopathy is a special type of tumor thromboembolism. We report the case of a patient who developed pulmonary tumor thrombotic microangiopathy with alveolar hemorrhage. Almost all patients with pulmonary tumor thrombotic microangiopathy die within 1 week of the onset of dyspnea; however, the prognosis in this case was better, with 10 weeks of survival from presentation. CASE PRESENTATION: A 62-year-old Japanese man was referred to our hospital with a 4-week history of dyspnea on exertion and severe pulmonary hypertension...
December 23, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29234749/sinus-lift-grafting-with-anorganic-bovine-bone-vs-50-autologous-bone-mixed-with-50-anorganic-bovine-bone-2-years-after-loading-results-from-a-randomised-controlled-trial
#20
Silvio Mario Meloni, Sascha Alekshander Jovanovic, Milena Pisano, Erta Xhanari, Giacomo De Riu, Antonio Tullio, Marco Tallarico
PURPOSE: To compare the outcome of implants inserted in maxillary sinuses augmented with anorganic bovine bone (ABB) grafts vs mixed 50% ABB and 50% autologous bone graft, using a lateral window approach. MATERIALS AND METHODS: This study was designed as a randomised controlled trial of parallel groups. Patients in need of an implant-supported prosthesis in a maxillary posterior area with a residual alveolar bone height no greater than 4 mm (range 0-4 mm) were recruited for lateral sinus grafting...
2017: European Journal of Oral Implantology
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