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JOURNAL ARTICLE
Yashaswinii Polaka, Evangeline P Christina, Karthik Krishna Ramakrishnan, Arunkumar Mohanakrishnan, Paarthipan Natarajan
Background Renal insufficiency, a critical concern in native and transplant kidneys, necessitates effective screening modalities for evaluation and management. Grayscale sonography has been a cornerstone in renal diagnostics, providing basic anatomical insights such as renal length, cortical thickness, and collecting system dilatation. Despite technological advancements, its impact on the differential diagnosis or management of renal disease remains limited, often showing normal findings in the presence of severe renal dysfunction...
March 2024: Curēus
#2
JOURNAL ARTICLE
Muhammad Shaheen, Anchit Bharat, Allon N Friedman, Shunhua Guo
Leukocyte chemotactic factor-2 amyloidosis (ALECT2) is a recently described subtype of amyloidosis. IgG4-related disease is a rare fibroinflammatory condition characterized by dense interstitial lymphoplasmacytic infiltrates and fibrosis. Membranous nephropathy and diabetic nephropathy are common causes of nephrotic syndrome. Here we report a 49-year-old Hispanic male patient with diabetes mellitus who presented with jaundice and pruritus. IgG4-related autoimmune pancreatitis was diagnosed through laboratory workup and ampulla biopsy...
April 17, 2024: Journal of Nephrology
#3
JOURNAL ARTICLE
Masatomo Ogata, Masaki Kato, Takamasa Miyauchi, Marie Murata-Hasegawa, Yuko Sakurai, Kazunobu Shinoda, Hajime Yamazaki, Yugo Shibagaki, Masahiko Yazawa
INTRODUCTION: Gastrointestinal complications are common after solid organ transplantation. New-onset inflammatory bowel disease (IBD) after transplantation (de novo) is a major differential diagnosis of diarrhea after liver transplantation (LT) because of its high incidence in the field. However, the incidence of IBD after kidney transplantation (KT) remains unknown. METHODS: This case series comprised six de novo IBD patients who had undergone KT at our hospital from April 1998 to December 2020...
2024: Inflammatory Intestinal Diseases
#4
JOURNAL ARTICLE
Stanislav Hresko, Martina Madarova, Miroslava Dobosova, Nikola Palusekova, Petra Niznerova, Stanislav Ziaran, Ivan Varga
C4d, a split product of C4 activation in classical and lectin pathways of the complement system activation, has been regarded as a footprint of tissue damage in antibody-mediated rejection in transplantology. The introduction of C4d staining into daily clinical practice aroused an ever-increasing interest in the role of antibody-mediated mechanisms in kidney allograft rejection. However, this marker of complement activation is also important in other various kidney glomerular pathologies such as immunoglobulin A nephropathy, membranoproliferative glomerulonephritis, lupus nephritis, and others...
2024: Bratislavské Lekárske Listy
#5
JOURNAL ARTICLE
Vanderlene L Kung, Gabriel Giannini, Cynthia C Nast
INTRODUCTION: Type 2 diabetes mellitus (DM) and diabetic kidney disease are increasing. Hepatitis C infection (HCV) occurs in 1% of the world population and can induce several kidney diseases. DM prevalence is increased in individuals with HCV; however, kidney diseases in those with both DM and HCV have not been assessed. Direct-acting antiviral agents (DAAs) became available for HCV treatment in 2014; it is unknown if DAAs altered the spectrum of kidney disease in patients with DM and HCV...
2024: Glomerular diseases
#6
REVIEW
Kim Solez, Garabed Eknoyan
Renal pathology is a relatively recent entry in nephrology. While diseases of the kidney are old, their study began in the 19th century with the report of Richard Bright of the lesions of end-stage kidney disease. Its easy diagnosis from albuminuria soon elevated Bright's nephritis into a leading cause of death. The transformative events in the care of these cases were renal replacement therapy that converted a fatal into a chronic disease, and kidney biopsy that allowed study of the course and pathogenesis of kidney disease...
April 2024: Clinical Transplantation
#7
Edgar Dehesa-Lopez, Sergio Saul Irizar-Santana, Miguel Angel Valdez-Cruz, Sarahy Sosa-Guerrero, Fatima Lopez-Moreno
Patients with end-stage renal disease (ESRD) who undergo kidney transplantation are at an increased risk of developing surgical and/or medical complications. Posterior reversible encephalopathy syndrome (PRES) is a rare complication that occurs in 0.34% of kidney transplant patients. It is characterized by a combination of neurological manifestations, risk factors, and characteristic radiological findings in neuroimaging studies. The development of PRES has been associated with various medical conditions and factors, including hypertension, the use of cytotoxic and immunosuppressive drugs, acute or chronic kidney disease, pre-eclampsia/eclampsia, autoimmune diseases, and solid organ and bone marrow transplantation...
March 2024: Curēus
#8
JOURNAL ARTICLE
Jorane-Tiana Robert, Ajay Rajaram, Pierre O Fiset, Chantal Bernard, Ratna Samanta, Shaifali Sandal
No abstract text is available yet for this article.
March 26, 2024: Journal of Nephrology
#9
JOURNAL ARTICLE
Huiyue Hu, Aihua Wu, Xiaodie Mu, Hua Zhou
The interleukin 1 (IL-1) family plays a significant role in the innate immune response. IL-1 receptor 2 (IL-1R2) is the decoy receptor of IL-1. It is a negative regulator that can be subdivided into membrane-bound and soluble types. IL-1R2 plays a role in the IL-1 family mainly through the following mechanisms: formation of inactive signaling complexes upon binding to the receptor auxiliary protein and inhibition of ligand IL-1 maturation. This review covers the roles of IL-1R2 in kidney disorders. Chronic kidney disease, acute kidney injury, lupus nephritis, IgA nephropathy, renal clear cell carcinoma, rhabdoid tumor of kidney, kidney transplantation, and kidney infection were all shown to have abnormal IL-1R2 expression...
March 22, 2024: Journal of Interferon & Cytokine Research
#10
Van Phan, John Aurora, Suma Gondi, Lisa Ceglia
BACKGROUND/OBJECTIVE: Celiac disease, an immune reaction to gluten causing nutrient malabsorption, and long-term glucocorticoid therapy adversely affect bone metabolism and increase fracture risk. CASE REPORT: A patient with long-standing celiac disease on a strict gluten-free diet and long-term glucocorticoid therapy status post kidney transplant for Sjögren syndrome-induced interstitial nephritis presented for management of osteoporosis. Initial evaluation was notable for secondary hyperparathyroidism, which resolved after switching to a gluten-free calcium citrate supplement...
2024: AACE Clinical Case Reports
#11
JOURNAL ARTICLE
Naonori Kumagai, Yoshitsugu Oikawa, Makiko Nakayama, Atsuko Kasajima, Kensuke Joh
No abstract text is available yet for this article.
March 21, 2024: Journal of Nephrology
#12
REVIEW
Ping Zhou, Ying Gao, Zhijuan Kong, Junlin Wang, Shuxuan Si, Wei Han, Jie Li, Zhimei Lv, Rong Wang
As a new type of anti-tumor immunotherapy, immune checkpoint inhibitors (ICIs) have improved the prognosis of multiple malignancies. However, renal complications are becoming more frequent. Nephrotoxicity often manifests as acute kidney injury (AKI), and the most common histopathological type is acute tubulointerstitial nephritis (ATIN). Based on previous studies of the incidence and potential risk factors for nephrotoxicity, in this review, we describe the mechanism of AKI after ICIs treatment, summarize the incidence, risk factors, and outcomes of AKI, and discuss the diagnosis and management of immune checkpoint inhibitors-associated acute kidney injury (ICI-AKI)...
2024: Frontiers in Immunology
#13
JOURNAL ARTICLE
Leidi Hernandez-Suarez, Eguzkiñe Diez-Martin, June Egiguren-Ortiz, Roberto Fernandez, Aitor Etxebarria, Egoitz Astigarraga, Cristina Miguelez, Andoni Ramirez-Garcia, Gabriel Barreda-Gómez
Immune disorders arise from complex genetic and environmental factors, which lead to dysregulation at the cellular and inflammatory levels and cause tissue damage. Recent research highlights the crucial role of reactive antibodies in autoimmune diseases and graft rejection, but their complex determination poses challenges for clinical use. Therefore, our study aimed to ascertain whether the presence of reactive antibodies against membrane antigens in tissues from both animal models and humans could serve as biomarkers in patients with autoimmune disorders...
February 7, 2024: International Journal of Molecular Sciences
#14
JOURNAL ARTICLE
Guizhen Yu, Jie Zhao, Meifang Wang, Yang Chen, Shi Feng, Bingjue Li, Cuili Wang, Yucheng Wang, Hong Jiang, Jianghua Chen
BACKGROUND: IgA vasculitis nephritis is the most common secondary IgA nephropathy. Urinary C4d have been identified associated with the development and progression in primary IgA nephropathy. However, its role in kidney disease progression of IgA vasculitis nephritis is still unclear. METHODS: This study enrolled 139 patients with IgA vasculitis nephritis (IgAVN), 18 healthy subjects, 23 Focal segmental glomerulosclerosis patients and 38 IgA nephropathy (IgAN) patients...
February 19, 2024: Nephrology, Dialysis, Transplantation
#15
JOURNAL ARTICLE
Fatemeh Nili, Elham Farahani, Mehran Moghimian, Issa Jahanzad, Farzaneh-Sadat Minoo, Samaneh Salarvand, Alireza Abdollahi, Seyed Ali Mirshahvalad
Data about the prevalence of biopsy-proven kidney diseases in Iran are rare, and none of the previous studies used electron microscopy for diagnosis. This study aimed to analyze the prevalence of biopsy-proven kidney diseases in Iran's primary referral center. To the best of our knowledge, this is the most extensive study carried out in Iran. Reports of kidney biopsy samples from patients referred to our center in 2007-2018 were reviewed for demographic data, clinical presentation, and final diagnosis. Statistical analyses were performed...
July 1, 2023: Saudi Journal of Kidney Diseases and Transplantation
#16
JOURNAL ARTICLE
Joel D Murphy, Tiffany N Caza, Clarissa A Cassol, Aaron Storey, Josephine M Ambruzs, Christie Boils, Patrick D Walker, Shree Sharma, Nidia Messias, Randolph Hennigar, Nicole K Andeen, Christine VanBeek, Matthew Palmer, Lakshna Sankar, Pooja Sanghi, Kumar Dinesh, Lance Dicker, Anatoly Urisman, Christopher P Larsen
INTRODUCTION: Antibrush border antibody disease (ABBA) is an autoimmune tubulointerstitial kidney disease that primarily affects older individuals and results in progressive kidney failure. It is rare with only 20 reported cases. Here, we describe a case series to further define the clinicopathologic spectrum and natural history, and to inform management. METHODS: We identified 67 patients with ABBA who underwent kidney biopsy, including 65 native and 2 transplants...
February 2024: KI Reports
#17
REVIEW
Tanzir I Britto, Mohammad E Hoque, Shaikh A Fattah
Dialysis in pediatric groups is complicated by a wide range of factors that can affect long-term prognosis. The purpose of this meta-analysis and systematic review is to better understand the demographic and clinical factors that affect dialysis success in children. We searched a variety of databases for relevant articles and included 14 reports that dealt with the case studies of pediatric patients undergoing dialysis for a wide range of renal diseases. Patients' demographics, clinical presentations, laboratory findings, and treatment outcomes were the primary areas of data collection...
January 2024: Curēus
#18
JOURNAL ARTICLE
Dan Li, Xian Xie, Ni Yin, Xueqin Wu, Bin Yi, Hao Zhang, Wei Zhang
BACKGROUND: tRNA-derived small RNAs (tsRNAs) are an emerging class of small noncoding RNAs derived from tRNA cleavage. SUMMARY: With the development of high-throughput sequencing, various biological roles of tsRNAs have been gradually revealed, including regulation of mRNA stability, transcription, translation, direct interaction with proteins and as epigenetic factors, etc. Recent studies have shown that tsRNAs are also closely related to renal disease. In clinical acute kidney injury (AKI) patients and preclinical AKI models, the production and differential expression of tsRNAs in renal tissue and plasma were observed...
February 2024: Kidney Diseases
#19
JOURNAL ARTICLE
Ahmet Murt, Elif Itir Sen, Eren Altun
No abstract text is available yet for this article.
February 1, 2024: Journal of Nephrology
#20
JOURNAL ARTICLE
Katharina Rohner, Matko Marlais, Yo Han Ahn, Alaa Ali, Abrar Alsharief, Anja Blejc Novak, Marta Brambilla, Evrim Kargin Cakici, Cengiz Candan, Nur Canpolat, Eugene Yu-Hin Chan, Stéphane Decramer, Madeleine Didsbury, Filipa Durao, Anne M Durkan, Ali Düzova, Thomas Forbes, Valentina Gracchi, Tulin Güngör, Tomoko Horinouchi, Belde Kasap Demir, Yasuko Kobayashi, Mikael Koskela, Eda Didem Kurt-Sukur, Claudio La Scola, Dean Langan, Xiaozhong Li, Gabriele Malgieri, Antonio Mastrangelo, Jeesu Min, Malgorzata Mizerska-Wasiak, Nabila Moussaoui, Aytul Noyan, Matti Nuutinen, Jennifer O'Gormon, Takayuki Okamoto, Louise Oni, Michiel Oosterveld, Malgorzata Pańczyk-Tomaszewska, Gonul Parmaksiz, Andrea Pasini, Pornpimol Rianthavorn, Joris Roelofs, Yunyan Shen, Rajiv Sinha, Rezan Topaloglu, Diletta Domenica Torres, Tomohiro Udagawa, Martin Wennerström, Yok Chin Yap, Kjell Tullus
BACKGROUND AND HYPOTHESIS: IgA vasculitis with nephritis (IgAVN) is the most common vasculitis in children. Treatment recommendations are, due to a lack of evidence, based on expert opinion resulting in variation. The aim of this study was to describe clinical presentation, treatment and outcome of an extremely large cohort of children with biopsy proven IgAVN to identify prognostic risk factors and signals of treatment efficacy. METHODS: Retrospective data were collected on 1148 children with biopsy proven IgAVN between 2005 and 2019 from 41 international paediatric nephrology centres across 25 countries and analyzed using multivariate analysis...
January 11, 2024: Nephrology, Dialysis, Transplantation
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