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https://www.readbyqxmd.com/read/28749549/a-double-blind-placebo-controlled-study-of-rituximab-in-patients-with-stiff-person-syndrome
#1
Marinos C Dalakas, Goran Rakocevic, James M Dambrosia, Harry Alexopoulos, Beverly McElroy
Objective In Stiff-Person Syndrome (SPS), an antibody-mediated impaired GABAergic neurotransmission is believed to cause muscle stiffness and spasms. Patients improve with GABA-enhancing drugs and IVIg, but several respond poorly and remain disabled. The need for more effective therapy prompted a trial with the anti-CD20 monoclonal antibody rituximab. Methods This was a placebo-controlled randomized trial of rituximab (two bi-weekly infusions of 1gr each). The primary outcome was a change in stiffness scores at 6 months...
July 27, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28749540/declining-prevalence-of-undiagnosed-hiv-in-melbourne-results-from-community-based-bio-behavioural-studies-of-gay-and-bisexual-men
#2
Mark Stoové, Jason Asselin, Alisa Pedrana, Toby Lea, Margaret Hellard, David Wilson, Garrett Prestage, John de Wit, Martin Holt
OBJECTIVE: To measure changes in undiagnosed HIV among gay and bisexual men (GBM) in Melbourne. METHODS: Undiagnosed HIV was compared between GBM recruited anonymously in 2008 in gay venues only and GBM anonymously or confidentially (results delivery) recruited in 2014 at gay venues and a community festival. Surveys were completed and oral fluid specimens collected for HIV testing; positive tests among GBM reporting being HIV-negative or unknown/untested were classified as undiagnosed...
July 27, 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/28749151/on-the-boundary-conditions-of-effort-losses-and-effort-gains-in-action-teams
#3
Joachim Hüffmeier, Michael Filusch, Jens Mazei, Guido Hertel, Andreas Mojzisch, Stefan Krumm
While people's willingness to work hard can be reduced in teams (i.e., effort losses in teams as compared with individual work), it is less recognized that teamwork can also stimulate additional efforts (i.e., effort gains). Building on and extending existing theory, we (a) suggest an integration of these two research streams, and (b) provide evidence for team-related effort gains in action teams. In a first study, we tested our predictions by reanalyzing a field data set of 302,576 swimming performances in individual and relay races (Neugart & Richiardi, 2013)...
July 27, 2017: Journal of Applied Psychology
https://www.readbyqxmd.com/read/28748639/how-nurses-cope-with-patient-death-a-systematic-review-and-qualitative-meta-synthesis
#4
REVIEW
Ruishuang Zheng, Susan Fiona Lee, Melissa Jane Bloomer
AIMS AND OBJECTIVES: To review literature on nurses' coping strategies with patient death. BACKGROUND: dealing with the loss of a patient was viewed as one of the most demanding and challenging encounters in clinical practice. Those nurses who are not competent in coping with patient death may be inadequate in supporting dying patients and their family members, and minimize the quality of end-of-life care. To get a broader understanding of how nurses cope with patient death and to develop meaningful and effective interventions, a systematic review which would help underpin the multidimensional approaches is needed...
July 26, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28748564/medicare-spending-for-breast-prostate-lung-and-colorectal-cancer-patients-in-the-year-of-diagnosis-and-year-of-death
#5
Christopher T Chen, Ling Li, Gabriel Brooks, Michael Hassett, Deborah Schrag
OBJECTIVE: To characterize spending patterns for Medicare patients with incident breast, prostate, lung, and colorectal cancer. DATA SOURCES/STUDY SETTING/STUDY DESIGN: 2007-2012 data from the Surveillance, Epidemiology, and End Results Program linked with Medicare fee-for-service claims. DATA COLLECTION/EXTRACTION METHODS: We calculate per-patient monthly and yearly mean and median expenditures, by cancer type, stage at diagnosis, and spending category, over the years of diagnosis and death...
July 26, 2017: Health Services Research
https://www.readbyqxmd.com/read/28748535/financial-incentives-and-physician-practice-participation-in-medicare-s-value-based-reforms
#6
Adam M Markovitz, Patricia P Ramsay, Stephen M Shortell, Andrew M Ryan
OBJECTIVES: To evaluate whether greater experience and success with performance incentives among physician practices are related to increased participation in Medicare's voluntary value-based payment reforms. DATA SOURCES/STUDY SETTING: Publicly available data from Medicare's Physician Compare (n = 1,278; January 2012 to November 2013) and nationally representative physician practice data from the National Survey of Physician Organizations 3 (NSPO3; n = 907,538; 2013)...
July 26, 2017: Health Services Research
https://www.readbyqxmd.com/read/28748366/clinical-features-of-psoriatic-arthritis-a-comprehensive-review-of-unmet-clinical-needs
#7
REVIEW
Angela McArdle, Stephen Pennington, Oliver FitzGerald
Psoriatic arthritis (PsA) is a form of inflammatory arthritis (IA) affecting approximately 0.25% of the population. It is a heterogeneous disorder associated with joint damage, disability, disfiguring skin disease and in severe cases, premature mortality. Inherently irreversible and frequently progressive, the process of joint damage begins at, or before, the clinical onset of disease. Early recognition and intervention is thus crucial to patient outcome. At disease onset, however, PsA often resembles other forms of arthritis-especially rheumatoid arthritis (RA)...
July 27, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28748219/envy-s-pathology-historical-contexts
#8
Lina Minou
This article is concerned with the physicality of envy primarily in early -modern, but also in eighteenth-century health contexts. The discussion brings together descriptions of the effects of envy on the body of the envier, mainly from works of physiology and health preservation, but also from literary and spiritual writings. These depictions of envy are studied beyond their symbolism and with a view to establish whether they are meaningful according to the medical theories of the time in which they occur...
2017: Wellcome Open Research
https://www.readbyqxmd.com/read/28748011/-intraoperative-management-of-esophageal-atresia-small-steps-that-cannot-be-ignored-in-madagascar
#9
Harifetra Mamy Richard Randriamizao, Aurélia Rakotondrainibe, Nadia Marie Philibertine Rahanitriniaina, Andriambelo Tovohery Rajaonera, Mamy Lalatiana Andriamanarivo
The management of esophageal atresia is still limited due to the precariousness of technical equipments in Madagascar. Our case study aims to highlight possible therapeutic options and to describe the progresses to be made so as to optimize treatment of this congenital pathology. We collected the medical records of all patients hospitalized for esophageal atresia in the Department of Surgical Reanimation at the University Hospital-JRA Antananarivo. The first patients admitted who survived for a period of 42 months (between January 2011 and June 2014) were included in the study...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28747555/tripchlorolide-induces-autophagy-in-lung-cancer-cells-by-inhibiting-the-pi3k-akt-mtor-pathway-and-improves-cisplatin-sensitivity-in-a549-ddp-cells
#10
Li-Min Chen, Tian-Jiao Song, Jian-Hong Xiao, Zheng-Hui Huang, Yong Li, Ting-Yan Lin
Tripchlorolide (T4) has been shown to induce A549 lung cancer cell death predominantly by activating an autophagy pathway. However, the underlying mechanism remains unclear. Herein, we demonstrated that compared with T4 treatment alone, pretreatment with wortmannin (an inhibitor of phosphatidylinositol 3-kinase), perifosine (an inhibitor of AKT) or rapamycin (an inhibitor of mTOR) combined with a subsequent T4 treatment significantly impaired the cell viability of A549 and A549/DDP lung cancer cells. We found that either treatment scheme markedly reduced the activity of P13K and AKT...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28747450/magnesium-hemostasis-and-outcomes-in-patients-with-intracerebral-hemorrhage
#11
Eric M Liotta, Shyam Prabhakaran, Rajbeer S Sangha, Robin A Bush, Alan E Long, Stephen A Trevick, Matthew B Potts, Babak S Jahromi, Minjee Kim, Edward M Manno, Farzaneh A Sorond, Andrew M Naidech, Matthew B Maas
OBJECTIVE: We tested the hypothesis that admission serum magnesium levels are associated with hematoma volume, hematoma growth, and functional outcomes in patients with intracerebral hemorrhage (ICH). METHODS: Patients presenting with spontaneous ICH were enrolled in an observational cohort study that prospectively collected demographic, clinical, laboratory, radiographic, and outcome data. We performed univariate and adjusted multivariate analyses to assess for associations between serum magnesium levels and initial hematoma volume, final hematoma volume, and in-hospital hematoma growth as radiographic measures of hemostasis, and functional outcome measured by the modified Rankin Scale (mRS) at 3 months...
July 26, 2017: Neurology
https://www.readbyqxmd.com/read/28746980/single-incision-sling-operations-for-urinary-incontinence-in-women
#12
REVIEW
Arjun Nambiar, June D Cody, Stephen T Jeffery, Patricia Aluko
BACKGROUND: Urinary incontinence has been shown to affect up to 50% of women. Studies in the USA have shown that up to 80% of these women have an element of stress urinary incontinence. This imposes significant health and economic burden on society and the women affected. Colposuspension and now mid-urethral slings have been shown to be effective in treating patients with stress incontinence. However, associated adverse events include bladder and bowel injury, groin pain and haematoma formation...
July 26, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28746951/-exercise-therapy-in-german-medical-rehabilitation-an-analysis-based-on-quantitative-routine-data
#13
Silke Brüggemann, Daniela Sewöster, Angela Kranzmann
Aim of this study This study describes the quantitative importance of exercise therapy in German medical rehabilitation based on 2014 routine data of the German Pension Insurance. It also shows changes in comparison with data from 2007. Methods Data from 710012 rehabilitation discharge letters comprising 83677802 treatments from central indications in medical rehabilitation were analysed descriptively. Results Overall 35.4% of treatments could be classified as exercise therapy. Total and relative duration, percentage of individual treatment and kind of exercise treatment varied between indications in 2007 as well as in 2014...
July 26, 2017: Die Rehabilitation
https://www.readbyqxmd.com/read/28746911/state-of-the-art-considerations-in-small-cell-lung-cancer-brain-metastases
#14
REVIEW
Rimas V Lukas, Vinai Gondi, David O Kamson, Priya Kumthekar, Ravi Salgia
BACKGROUND: Small cell lung cancer (SCLC) frequently leads to development of brain metastases. These unfortunately continue to be associated with short survival. Substantial advances have been made in our understanding of the underlying biology of disease. This understanding on the background of previously evaluated and currently utilized therapeutic treatments can help guide the next steps in investigations into this disease with the potential to influence future treatments. DESIGN: A comprehensive review of the literature covering epidemiology, pathophysiology, imaging characteristics, prognosis, and therapeutic management of SCLC brain metastases was performed...
July 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28746316/efficacy-of-prophylactic-use-of-ciprofloxacin-and-metronidazole-in-mild-and-moderately-severe-acute-pancreatitis
#15
A K Mandal, S Chaudhary, B Shrestha, M S Paudel, N S Poudyal, B N Paudel, B Bhattarai, S K Ray, N M Ray
INTRODUCTION: There are new concepts and developments in the diagnosis and management of acute pancreatitis. Current evidence suggests that there is no role of prophylactic antibiotics use in acute pancreatitis. However, it is still a common practice to administer prophylactic antibiotics in a country like Nepal. So, we have conducted a study in mild and moderately severe acute pancreatitis to study the efficacy of prophylactic antibiotics. METHODS: A case control study was conducted among 76 patients comparing efficacy of prophylactic antibiotics versus no antibiotics in patients with mild and moderately severe acute pancreatitis...
April 2017: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/28746123/a-change-in-lumbar-sagittal-alignment-after-single-level-anterior-lumbar-interbody-fusion-for-lumbar-degenerative-spondylolisthesis-with-normal-sagittal-balance
#16
Chi Heon Kim, Chun Kee Chung, Sung Bae Park, Seung Heon Yang, Jung-Hee Kim
STUDY DESIGN: Retrospective analysis. OBJECTIVE: The object is to assess the correlation between whole lumbar lordosis (LL) and the segmental angle (SA) after single-level anterior lumbar interbody fusion for degenerative lumbar spondylolisthesis. SUMMARY OF BACKGROUND DATA: The restoration of the SA at lower lumbar spine is meaningful, considering it contributes approximately 60% of LL, and revision surgery due to flat back or adjacent segment pathology was necessary decades after the initial surgery...
August 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28746069/barriers-to-medical-students-electronic-health-record-access-can-impede-their-preparedness-for-practice
#17
Catherine M Welcher, William Hersh, Blaine Takesue, Victoria Stagg Elliott, Richard E Hawkins
Medical students need hands-on experience documenting clinical encounters as well as entering orders to prepare for residency and become competent physicians. In the era of paper medical records, students consistently acquired experience writing notes and entering orders as part of their clinical experience. Over the past decade, however, patient records have transitioned from paper to electronic form. This change has had the unintended consequence of limiting medical students' access to patient records. This restriction has meant that many students leave medical school without the appropriate medical record skills for transitioning to residency...
July 25, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28746020/pembrolizumab-induced-pancytopenia-a-case-report
#18
Dinesh Atwal, Krishna P Joshi, Rahul Ravilla, Fade Mahmoud
INTRODUCTION: Programmed death receptor-1 blockade with pembrolizumab is approved by the US Food and Drug Administration to treat patients with metastatic melanoma. Activating T cells to fight cancer may cause immune-mediated adverse events. Pembrolizumab-induced pancytopenia has not been previously reported in the medical literature, to our knowledge. CASE PRESENTATION: A 52-year-old Caucasian woman with a diagnosis of metastatic melanoma of the rectum experienced multiple adverse events along her course of therapy with pembrolizumab, ranging from colitis, hepatitis, gastritis, and vitiligo after the fifth cycle of pembrolizumab; to knee synovitis after the 14th cycle; and to severe pancytopenia after the 18th cycle of pembrolizumab...
2017: Permanente Journal
https://www.readbyqxmd.com/read/28745974/role-of-total-ankle-arthroplasty-in-stiff-ankles
#19
James W Brodsky, Justin M Kane, Akira Taniguchi, Scott Coleman, Yahya Daoud
BACKGROUND: The decision tree for the operative treatment of end-stage ankle arthritis involves either ankle arthrodesis (AA) or total ankle arthroplasty (TAA). Although both have documented success providing diminished pain, improved patient-centered outcomes, and improved objective measures of function, arthroplasty is unique in its ability to preserve motion at the tibiotalar joint. Arthroplasty procedures are normally thought of as a motion-sparing surgery rather than a motion-producing procedure, which may limit its success in patients with stiff ankles...
July 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28745480/controllable-photovoltaic-effect-of-micro-array-derived-from-epitaxial-tetragonal-bifeo3-films
#20
Zengxing Lu, Peilian Li, Jianguo Wan, Zhifeng Huang, Guo Tian, Danfeng Pan, Zhen Fan, Xingsen Gao, Jun-Ming Liu
Recently, ferroelectric photovoltaic (FePV) effect has attracted great interest due to its potential in developing optoelectronic devices such as solar cell and electric-optical sensors. It is important for actual applications to realize controllable photovoltaic process in ferroelectric-based materials. In this work, we have prepared well-ordered micro-arrays based on epitaxially tetragonal BiFeO3 (T-BFO) films by pulsed laser deposition technique. Polarization-dependent photocurrent image was directly observed by conductive atomic force microscope under ultraviolet illumination...
July 26, 2017: ACS Applied Materials & Interfaces
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